Genistein Affects Her2 Protein Concentration, Activation And Promoter Regulation Via Estrogen Receptor-And Non-Estrogen Receptor-Mediated Mechanisms, Mary S. Sakla, Pete J. Ansell, Nader S. Shenouda, Dennis B. Lubahn, Ruth S. Macdonald
Ruth S. MacDonald
The HER2 proto-oncogene, a member of the epidermal growth factor receptor family, is overexpressed in 20–30% of breast cancers. Genistein, the main soy isoflavone, interacts with estrogen receptors (ER) and it is also a potent tyrosine kinase inhibitor. Previously, our laboratory found that genistein delayed mammary tumor onset in transgenic mice that overexpress HER2 gene. Our goal was to define the mechanism through which genistein affects mammary tumorigenesis inHER2 overexpressing mice. We hypothesized that genistein inhibits HER2 activation and expression through ER-dependent and ER-independent mechanisms. Genistein inhibited total HER2 protein expression and tyrosine phosphorylation in BT-474, an ERα (−) and ...
Phytosterol Pygeum Africanum Regulates Prostate Cancer In Vitro And In Vivo, 2017 University of Missouri
Phytosterol Pygeum Africanum Regulates Prostate Cancer In Vitro And In Vivo, Nader S. Shenouda, Mary S. Sakla, Leslie G. Newton, Cynthia Besch-Williford, Norman M. Greenberg, Ruth S. Macdonald, Dennis B. Lubahn
Ruth S. MacDonald
Prostate cancer is an important public health problem. It is an excellent candidate disease for chemo-prevention because prostate cancer is typically slow growing and is usually diagnosed in elderly males. Pygeum africanum (Prunus africana or Rosaceae) is an African prune (plum) tree found in tropical Africa. An extract from the bark of Pygeum africanum has been used in Europe as a prevention and treatment of prostate disorders including benign prostatic hypertrophy (BPH). More recently in the USA, the phytotherapeutic preparations of Pygeum africanum and Saw palmetto have been marketed for prostate health including prostate cancer prevention and treatment.
Soy Isoflavones Have An Antiestrogenic Effect And Alter Mammary Promoter Hypermethylation In Healthy Premenopausal Women1, 2017 University of Missouri School of Medicine
Soy Isoflavones Have An Antiestrogenic Effect And Alter Mammary Promoter Hypermethylation In Healthy Premenopausal Women1, Wenyi Qin, Weizhu Zhu, Huidong Shi, John E. Hewett, Rachel L. Ruhlen, Ruth S. Macdonald, George E. Rottinghaus, Yin-Chieh Chien, Edward R. Sauter
Ruth S. MacDonald
We hypothesized that soy isoflavones would have dose related estrogenic and methylation effects. 34 healthy premenopausal women were prospectively enrolled and randomized in double-blind fashion to receive either 40 mg or 140 mg isoflavones daily through one menstrual cycle. Breast specific (NAF) and systemic (serum) estrogenic effects were assessed measuring the estrogenic marker complement (C)3 and changes in cytology, while methylation effects were evaluated in mammary ductoscopy (MD) specimens using methylation specific PCR assessment of five genes (p16, RASSF1A, RARβ2, ER, and CCND2) associated with breast carcinogenesis. Serum genistein significantly increased post treatment in women consuming both isoflavone doses ...
Improved Corn Ethanol Fermentation And Oil Distribution By Using Polysaccharide Hydrolyzing Enzymes, 2017 Iowa State University
Improved Corn Ethanol Fermentation And Oil Distribution By Using Polysaccharide Hydrolyzing Enzymes, Linxing Yao, Pawarisa Luangthongkam, Tong Wang, Buddhi P. Lamsal, Tao Fei, Hui Wang, Lawrence A. Johnson, Mohan Dasari
Buddhi P. Lamsal
We determined the effects of a commercial proprietary formulation of polysaccharide hydrolyzing enzymes on ethanol fermentation performance, oil partitioning and recovery, and quality of dried distillers grains with solubles (DDGS) on a 1.5-L and 50-L fermentation scale. The enzyme was added at the start of fermentation. Whole beer was subjected to beer well incubation, distillation, and separation of thin stillage from the wet cake. The enzyme promoted faster ethanol production without affecting the final ethanol yield. The enzyme treatments resulted in 8–18% higher wet yield of thin stillage than the control, 13–21% of oil increase in thin ...
Homocysteine Metabolism And Its Relation To Health And Disease., 2017 Iowa State University
Homocysteine Metabolism And Its Relation To Health And Disease., Kelly T. Williams, Buddhi P. Lamsal
Buddhi P. Lamsal
Homocysteine is a metabolic intermediate in methyl group metabolism that is dependent on a number of nutritional B-vitamin cofactors. An emerging aspect of homocysteine metabolism is its relation to health and disease. Perturbations of homocysteine metabolism, particularly intracellular and subsequently circulating accumulation of homocysteine (i.e., hyperhomocysteinemia), are associated with vascular disease risk, as well as other pathologies. However, intervention with B-vitamin supplementation has been shown to successfully restore normal homocysteine concentrations, but without concomitant reductions in disease risk. Thus, the mechanistic relation between homocysteine balance and disease states, as well as the value of homocysteine management, remains an area ...
Let Them Eat Beef: Effects Of Beef Consumption On Markers Of Metabolic Syndrome, 2017 South Dakota State University
Let Them Eat Beef: Effects Of Beef Consumption On Markers Of Metabolic Syndrome, Kristin L. Olson
Theses and Dissertations
To determine the effects of a diet that provides 30% energy from protein with ½ as lean, red meat on risk factors of metabolic syndrome in humans. This pilot study was a 3- month, randomized, control, intervention trial with 33 participants (Beef-Intervention n=18; DASH-Control n=15) who displayed markers of metabolic syndrome. Registered Dietitians Nutritionists recruited and educated participants on Beef-Intervention Lean Beef Pattern, (30% of energy from protein with ½ as lean red meat, 40% carbohydrate, 30% fat) or DASH-Control dietary pattern, (15% of energy from protein, 55% carbohydrate and 30 % fat). Of the 33 participants who completed ...
The Effect Of Nitrate Supplementation On Exercise Tolerance And Performance: A Systematic Review And Meta-Analysis, 2017 South Dakota State University
The Effect Of Nitrate Supplementation On Exercise Tolerance And Performance: A Systematic Review And Meta-Analysis, Gavin Van De Walle
Theses and Dissertations
The purpose of this paper was to systematically review the current literature and evaluate the overall efficacy of nitrate supplementation on exercise tolerance and performance by meta-analysis. Studies were eligible for inclusion if they met the following criteria: 1) were an experimental trial published in an English peer-reviewed journal; 2) compared the effects of inorganic nitrate consumption with a non-bioactive supplement control or placebo; 3) used a quantifiable measure of exercise performance; and 4) was carried out in apparently healthy participants without disease. A total of 29 studies were identified that investigated the effects of nitrate supplementation on exercise tolerance ...
Increasing Fruit And Vegetable Intake Among Children And Youth Through Gardening-Based Interventions: A Systematic Review, Mateja R. Savoie Roskos
NDFS Faculty Publications
Background: Although there are numerous health benefits associated with eating fruit and vegetables (FV), few children are consuming recommended amounts. Gardening interventions have been implemented in various settings in an effort to increase FV consumption of children by expanding knowledge, exposure, and preferences for a variety of FV.
Objective: The purpose of this review was to identify the effectiveness of gardening interventions that have been implemented to increase FV consumption among children.
Methods: A systematic review was conducted using four electronic databases: Web of Science, PubMed, Scopus, and CINAHL. English language studies conducted in developed countries between January 2005 and ...
“I Don’T Eat When I’M Sick”: Older People’S Food And Mealtime Experiences In Hospital, 2016 Queensland University of Technology
“I Don’T Eat When I’M Sick”: Older People’S Food And Mealtime Experiences In Hospital, Kelti Hope, Maree Ferguson, Dianne P. Reidlinger, Ekta Agarwal
Introduction, 2016 Univ. of Western Ontario - Univ. de Poitiers
Introduction, Jessy Neau
Le Monde français du dix-huitième siècle
The introduction reviews the coherence of the volume from the solicited report on the Weldon librarian's exhibit on Paul et Virginie, to the articles spanning the fields of culinary imports, history of arts, travel diaries, Sade's feminism, and the interpretation of Rousseau by Deleuze.
Connecting Culturally And Spiritually To Healthy Eating: A Community Assessment With Native Hawaiians, 2016 Waimanalo Health Center
Connecting Culturally And Spiritually To Healthy Eating: A Community Assessment With Native Hawaiians, Mary Frances Oneha, Joan Dodgson, Mabel Ho`Oipo Decambra, Carol Titcomb, Rachelle Enos, Sandie Morimoto-Ching
Asian/Pacific Island Nursing Journal
Many of the chronic illnesses disproportionately experienced by Native Hawaiians are directly related to poor diets and long-standing obesity beginning in childhood. We report on the findings of in-depth key informant interviews (N = 14) that took place in two Native Hawaiian communities as part of a larger, community-based participatory research study that included a community assessment through individual interviews and focused group discussions, and a pilot intervention targeting pregnant women, their infants, and families. Four categories emerged from the qualitative analysis of interview transcripts that described an understanding of “healthy eating”: family roles and responsibilities, aspects of community and physical ...
Enhancing Vegetable Intake In Infants And Toddlers Through Parental Complementary Feeding Education, 2016 University of Arkansas, Fayetteville
Enhancing Vegetable Intake In Infants And Toddlers Through Parental Complementary Feeding Education, Sophia Testa
The Eleanor Mann School of Nursing Undergraduate Honors Theses
This research project investigated the outcomes of educating parents of infants between the ages of 6 months and 12 months on the importance of including vegetables in complementary feedings on the infant’s vegetable consumption. The efficiency of teaching was measured by comparing physical measurements and quantity of vegetables consumed by infants whose parents received education with the same data from infants whose parents did not receive education on inclusion of vegetable in complementary feedings. The results found contributed to Dr. Shreve’s research on childhood obesity in the Northwest Arkansas population and to the knowledge of parental education with ...
Effect Of Varying Rumen Degradable And Undegradable Protein On Milk Production And Nitrogen Efficiency In Lactating Dairy Cows Under Summer Conditions, 2016 University of Tennessee, Knoxville
Effect Of Varying Rumen Degradable And Undegradable Protein On Milk Production And Nitrogen Efficiency In Lactating Dairy Cows Under Summer Conditions, Jeffrey D. Kaufman
The objective is to determine the effect of reducing nitrogen input through feeding low rumen degradable protein (RDP) and rumen undegradable protein (RUP) proportions on milk production, nitrogen efficiency and metabolism in heat-stressed cows. Forty-eight mid-lactating, Holstein cows were assigned to treatments using a randomized block design in a 2x2 factorial arrangement of treatments (n = 12/treatment). Treatments included two levels of RDP (10 and 8%) and two levels of RUP (8 and 6%). From d 1 to 21, a common diet (10% RDP-8% RUP) was fed to cows followed with their respective treatment diets fed from d 22 to ...
Investigating The Relationship Among Sleep, Stress, And Body Mass Index In At-Risk First-Year College Students, Grace A. Violette
Electronic Theses and Dissertations
The study objective was to investigate relationships among body mass index (BMI), sleep quality/duration, and perceived stress in 1,176 first semester college students who enrolled in Get Fruved, an 8-state social marketing intervention to prevent unwanted weight gain. Research was limited to first-year college students at-risk for unwanted weight gain. Eligibility was based on self-report of inadequate fruit and vegetable intake and subjects meeting one or more health-risk criteria (e.g., high BMI). Students (mean age=181 years; 65% white) completed physical measurements and an online survey, including the Pittsburgh Sleep Quality Index (PSQI) (score range 0-21; ˃5 ...
Preparing For Effective Program Dissemination And Implementation: An Analysis Of Problems And Proposals For The Icook 4-H Program, 2016 University of Maine - Main
Preparing For Effective Program Dissemination And Implementation: An Analysis Of Problems And Proposals For The Icook 4-H Program, Jodi L. Randall
Electronic Theses and Dissertations
While much effort has gone into the creation of obesity prevention programs like iCook 4-H, such programs remain largely under-utilized. The disconnect between research and practice highlights the necessity of dissemination and implementation strategies to ensure programs become adopted into practice. Creating a well-informed systematic approach to implementation will ensure that the iCook 4-H program will be implemented efficaciously and sustainably to improve the health of generations to come. The goal of this research was to implement the pilot dissemination and describe the findings in the context of the Quality Implementation Framework. The objectives were to report outcomes of the ...
Exploring The Connection Between Community Food Security Initiatives And Social-Cognitive Factors On Dietary Intake, Diana Cuy Castellanos, Josh Keller, Emma Majchrzak
Diana Cuy Castellanos
Food insecurity and poor dietary consumption continue to impact low-income populations in the U.S. However, communities are developing ways to address it at the local level. Community Food Security Initiatives (CFSI) focus on increasing a sustainable, healthy food supply and food system while addressing food insecurity and dietary quality within a community.
The purpose of this study was two-fold: (1) explore CFSIs in low-income areas in a metropolitan Midwest city and (2) examine the effects of the initiatives along with other social-cognitive factors on fruit and vegetable consumption in persons participating in local CFSIs.
This was a mixed-methods study ...
The Prevalence And Practice Impact Of Weight Bias Amongst Australian Dietitians, 2016 Bond University
The Prevalence And Practice Impact Of Weight Bias Amongst Australian Dietitians, Tara Diversi, Roger Hughes, K J. Burke
Faculty of Health Sciences & Medicine Publications
This study explored weight bias amongst Australian Accredited Practising Dietitians (APDs) and the effect of client weight status on dietetic practice.
Participants were 201 APDs, recruited using purposive sampling. A self-administered questionnaire, the fat phobia scale (FPS), was completed to assess explicit weight bias. Participants were then randomized to receive either a female within the healthy weight range or female with obesity, accompanied by an identical case study for a condition unrelated to weight. Participants assessed the client based on data provided, provided recommendations and rated their perception of the client.
Mean FPS scores indicated mild fat ...
Food Cost And Nutrient Availability In Urban Indonesia: Estimates For Food Policy Analysis, 2016 International Food Policy Research Institute
Food Cost And Nutrient Availability In Urban Indonesia: Estimates For Food Policy Analysis, Tesfaye Teklu, Helen H. Jensen
Evaluating the effects of economic growth and the effectiveness of targeted government intervention requires identification of tarket groups and information on food and nutrient consumption patterns. A model of nutrient consumption linked to food choice behaviour is used to evaluate nutrient availability in urban Indonesia. Nutrient demand responses varied significantly across income levels
Early Nutritional Programming To Enhance The Utilization Of Plant Based Diets In Fish (Largemouth Bass, Micropterus Salmoides), 2016 Kentucky State University
Early Nutritional Programming To Enhance The Utilization Of Plant Based Diets In Fish (Largemouth Bass, Micropterus Salmoides), Maya Rene Jackson, Amit Kumar Yadav, Waldemar Rossi
Aquaculture has been the fastest growing animal food-producing sector for over half a century. Sustainable aquaculture should include replacement of fish-based feed sources by plant-based ingredients. However, this approach is often impeded by poor growth in carnivorous fish such as largemouth bass (LMB, Micropterus salmoides) fed high levels of plant-based protein. Therefore, our overall goal of the present work was to develop alternative methods of utilizing the plant-based diets (PBD) for sustainable LMB production. When fish is exposed to PBD early in their life, they may accept them more efficiently at later stages (so called Nutritional Programing, NP). Therefore, we ...
Higher Unsaturated Fatty Acid Intake And Aerobic Training Are Related With Lower Intramyocellular Lipid In Older Adults, Hillary D. Mclean
Title: Higher Unsaturated Fatty Acid Intake and Aerobic Training are Related to Lower Intramyocellular Lipid in Older Adults
1Hillary McLean, 2Maja Redzic, and 3D. Travis Thomas
Department: 1Department of Agriculture, 2Department of Pharmacology and Nutritional Sciences, and 3Department of Clinical Sciences
Funding: R21AG046762-01A1, UL1TR000117, T32DK007778-16
Word Count: 298/300
Intramyocellular lipid (IMCL) is associated with metabolic dysfunction in aging. Exercise is known to influence IMCL accumulation and was recently observed to have a direct association with vitamin D status (25(OH)D) in our lab. In addition, we observed an inverse association between IMCL ...