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Genistein Affects Her2 Protein Concentration, Activation And Promoter Regulation Via Estrogen Receptor-And Non-Estrogen Receptor-Mediated Mechanisms, Mary S. Sakla, Pete J. Ansell, Nader S. Shenouda, Dennis B. Lubahn, Ruth S. MacDonald 2017 University of Missouri

Genistein Affects Her2 Protein Concentration, Activation And Promoter Regulation Via Estrogen Receptor-And Non-Estrogen Receptor-Mediated Mechanisms, Mary S. Sakla, Pete J. Ansell, Nader S. Shenouda, Dennis B. Lubahn, Ruth S. Macdonald

Ruth S. MacDonald

The HER2 proto-oncogene, a member of the epidermal growth factor receptor family, is overexpressed in 20–30% of breast cancers. Genistein, the main soy isoflavone, interacts with estrogen receptors (ER) and it is also a potent tyrosine kinase inhibitor. Previously, our laboratory found that genistein delayed mammary tumor onset in transgenic mice that overexpress HER2 gene. Our goal was to define the mechanism through which genistein affects mammary tumorigenesis inHER2 overexpressing mice. We hypothesized that genistein inhibits HER2 activation and expression through ER-dependent and ER-independent mechanisms. Genistein inhibited total HER2 protein expression and tyrosine phosphorylation in BT-474, an ERα (−) and ...


Phytosterol Pygeum Africanum Regulates Prostate Cancer In Vitro And In Vivo, Nader S. Shenouda, Mary S. Sakla, Leslie G. Newton, Cynthia Besch-Williford, Norman M. Greenberg, Ruth S. MacDonald, Dennis B. Lubahn 2017 University of Missouri

Phytosterol Pygeum Africanum Regulates Prostate Cancer In Vitro And In Vivo, Nader S. Shenouda, Mary S. Sakla, Leslie G. Newton, Cynthia Besch-Williford, Norman M. Greenberg, Ruth S. Macdonald, Dennis B. Lubahn

Ruth S. MacDonald

Background

Prostate cancer is an important public health problem. It is an excellent candidate disease for chemo-prevention because prostate cancer is typically slow growing and is usually diagnosed in elderly males. Pygeum africanum (Prunus africana or Rosaceae) is an African prune (plum) tree found in tropical Africa. An extract from the bark of Pygeum africanum has been used in Europe as a prevention and treatment of prostate disorders including benign prostatic hypertrophy (BPH). More recently in the USA, the phytotherapeutic preparations of Pygeum africanum and Saw palmetto have been marketed for prostate health including prostate cancer prevention and treatment.

Methods ...


Soy Isoflavones Have An Antiestrogenic Effect And Alter Mammary Promoter Hypermethylation In Healthy Premenopausal Women1, Wenyi Qin, Weizhu Zhu, Huidong Shi, John E. Hewett, Rachel L. Ruhlen, Ruth S. MacDonald, George E. Rottinghaus, Yin-Chieh Chien, Edward R. Sauter 2017 University of Missouri School of Medicine

Soy Isoflavones Have An Antiestrogenic Effect And Alter Mammary Promoter Hypermethylation In Healthy Premenopausal Women1, Wenyi Qin, Weizhu Zhu, Huidong Shi, John E. Hewett, Rachel L. Ruhlen, Ruth S. Macdonald, George E. Rottinghaus, Yin-Chieh Chien, Edward R. Sauter

Ruth S. MacDonald

We hypothesized that soy isoflavones would have dose related estrogenic and methylation effects. 34 healthy premenopausal women were prospectively enrolled and randomized in double-blind fashion to receive either 40 mg or 140 mg isoflavones daily through one menstrual cycle. Breast specific (NAF) and systemic (serum) estrogenic effects were assessed measuring the estrogenic marker complement (C)3 and changes in cytology, while methylation effects were evaluated in mammary ductoscopy (MD) specimens using methylation specific PCR assessment of five genes (p16, RASSF1A, RARβ2, ER, and CCND2) associated with breast carcinogenesis. Serum genistein significantly increased post treatment in women consuming both isoflavone doses ...


Improved Corn Ethanol Fermentation And Oil Distribution By Using Polysaccharide Hydrolyzing Enzymes, Linxing Yao, Pawarisa Luangthongkam, Tong Wang, Buddhi P. Lamsal, Tao Fei, Hui Wang, Lawrence A. Johnson, Mohan Dasari 2017 Iowa State University

Improved Corn Ethanol Fermentation And Oil Distribution By Using Polysaccharide Hydrolyzing Enzymes, Linxing Yao, Pawarisa Luangthongkam, Tong Wang, Buddhi P. Lamsal, Tao Fei, Hui Wang, Lawrence A. Johnson, Mohan Dasari

Buddhi P. Lamsal

We determined the effects of a commercial proprietary formulation of polysaccharide hydrolyzing enzymes on ethanol fermentation performance, oil partitioning and recovery, and quality of dried distillers grains with solubles (DDGS) on a 1.5-L and 50-L fermentation scale. The enzyme was added at the start of fermentation. Whole beer was subjected to beer well incubation, distillation, and separation of thin stillage from the wet cake. The enzyme promoted faster ethanol production without affecting the final ethanol yield. The enzyme treatments resulted in 8–18% higher wet yield of thin stillage than the control, 13–21% of oil increase in thin ...


Homocysteine Metabolism And Its Relation To Health And Disease., Kelly T. Williams, Buddhi P. Lamsal 2017 Iowa State University

Homocysteine Metabolism And Its Relation To Health And Disease., Kelly T. Williams, Buddhi P. Lamsal

Buddhi P. Lamsal

Homocysteine is a metabolic intermediate in methyl group metabolism that is dependent on a number of nutritional B-vitamin cofactors. An emerging aspect of homocysteine metabolism is its relation to health and disease. Perturbations of homocysteine metabolism, particularly intracellular and subsequently circulating accumulation of homocysteine (i.e., hyperhomocysteinemia), are associated with vascular disease risk, as well as other pathologies. However, intervention with B-vitamin supplementation has been shown to successfully restore normal homocysteine concentrations, but without concomitant reductions in disease risk. Thus, the mechanistic relation between homocysteine balance and disease states, as well as the value of homocysteine management, remains an area ...


Let Them Eat Beef: Effects Of Beef Consumption On Markers Of Metabolic Syndrome, Kristin L. Olson 2017 South Dakota State University

Let Them Eat Beef: Effects Of Beef Consumption On Markers Of Metabolic Syndrome, Kristin L. Olson

Theses and Dissertations

To determine the effects of a diet that provides 30% energy from protein with ½ as lean, red meat on risk factors of metabolic syndrome in humans. This pilot study was a 3- month, randomized, control, intervention trial with 33 participants (Beef-Intervention n=18; DASH-Control n=15) who displayed markers of metabolic syndrome. Registered Dietitians Nutritionists recruited and educated participants on Beef-Intervention Lean Beef Pattern, (30% of energy from protein with ½ as lean red meat, 40% carbohydrate, 30% fat) or DASH-Control dietary pattern, (15% of energy from protein, 55% carbohydrate and 30 % fat). Of the 33 participants who completed ...


The Effect Of Nitrate Supplementation On Exercise Tolerance And Performance: A Systematic Review And Meta-Analysis, Gavin Van De Walle 2017 South Dakota State University

The Effect Of Nitrate Supplementation On Exercise Tolerance And Performance: A Systematic Review And Meta-Analysis, Gavin Van De Walle

Theses and Dissertations

The purpose of this paper was to systematically review the current literature and evaluate the overall efficacy of nitrate supplementation on exercise tolerance and performance by meta-analysis. Studies were eligible for inclusion if they met the following criteria: 1) were an experimental trial published in an English peer-reviewed journal; 2) compared the effects of inorganic nitrate consumption with a non-bioactive supplement control or placebo; 3) used a quantifiable measure of exercise performance; and 4) was carried out in apparently healthy participants without disease. A total of 29 studies were identified that investigated the effects of nitrate supplementation on exercise tolerance ...


Increasing Fruit And Vegetable Intake Among Children And Youth Through Gardening-Based Interventions: A Systematic Review, Mateja R. Savoie Roskos 2017 Utah State University

Increasing Fruit And Vegetable Intake Among Children And Youth Through Gardening-Based Interventions: A Systematic Review, Mateja R. Savoie Roskos

NDFS Faculty Publications

Background: Although there are numerous health benefits associated with eating fruit and vegetables (FV), few children are consuming recommended amounts. Gardening interventions have been implemented in various settings in an effort to increase FV consumption of children by expanding knowledge, exposure, and preferences for a variety of FV.
Objective: The purpose of this review was to identify the effectiveness of gardening interventions that have been implemented to increase FV consumption among children.
Methods: A systematic review was conducted using four electronic databases: Web of Science, PubMed, Scopus, and CINAHL. English language studies conducted in developed countries between January 2005 and ...


“I Don’T Eat When I’M Sick”: Older People’S Food And Mealtime Experiences In Hospital, Kelti Hope, Maree Ferguson, Dianne P. Reidlinger, Ekta Agarwal 2016 Queensland University of Technology

“I Don’T Eat When I’M Sick”: Older People’S Food And Mealtime Experiences In Hospital, Kelti Hope, Maree Ferguson, Dianne P. Reidlinger, Ekta Agarwal

Ekta Agarwal

Background

Inadequate dietary intake is a common problem amongst older acute-care patients and has been identified as an independent risk factor for in-hospital mortality. This study aimed to explore whether food and mealtime experiences contribute to inadequate dietary intake in older people during hospitalisation.

Methods

This was a qualitative phenomenological study, data for which were collected using semi-structured interviews over a three-week period. During this time, 26 patients aged 65 years or more, admitted to medical and surgical wards in a tertiary acute-care hospital, were asked to participate if they were observed to eat less than half of the meal ...


Introduction, Jessy Neau 2016 Univ. of Western Ontario - Univ. de Poitiers

Introduction, Jessy Neau

Le Monde français du dix-huitième siècle

The introduction reviews the coherence of the volume from the solicited report on the Weldon librarian's exhibit on Paul et Virginie, to the articles spanning the fields of culinary imports, history of arts, travel diaries, Sade's feminism, and the interpretation of Rousseau by Deleuze.


Connecting Culturally And Spiritually To Healthy Eating: A Community Assessment With Native Hawaiians, Mary Frances Oneha, Joan Dodgson, Mabel Ho`oipo DeCambra, Carol Titcomb, Rachelle Enos, Sandie Morimoto-Ching 2016 Waimanalo Health Center

Connecting Culturally And Spiritually To Healthy Eating: A Community Assessment With Native Hawaiians, Mary Frances Oneha, Joan Dodgson, Mabel Ho`Oipo Decambra, Carol Titcomb, Rachelle Enos, Sandie Morimoto-Ching

Asian/Pacific Island Nursing Journal

Many of the chronic illnesses disproportionately experienced by Native Hawaiians are directly related to poor diets and long-standing obesity beginning in childhood. We report on the findings of in-depth key informant interviews (N = 14) that took place in two Native Hawaiian communities as part of a larger, community-based participatory research study that included a community assessment through individual interviews and focused group discussions, and a pilot intervention targeting pregnant women, their infants, and families. Four categories emerged from the qualitative analysis of interview transcripts that described an understanding of “healthy eating”: family roles and responsibilities, aspects of community and physical ...


Enhancing Vegetable Intake In Infants And Toddlers Through Parental Complementary Feeding Education, Sophia Testa 2016 University of Arkansas, Fayetteville

Enhancing Vegetable Intake In Infants And Toddlers Through Parental Complementary Feeding Education, Sophia Testa

The Eleanor Mann School of Nursing Undergraduate Honors Theses

This research project investigated the outcomes of educating parents of infants between the ages of 6 months and 12 months on the importance of including vegetables in complementary feedings on the infant’s vegetable consumption. The efficiency of teaching was measured by comparing physical measurements and quantity of vegetables consumed by infants whose parents received education with the same data from infants whose parents did not receive education on inclusion of vegetable in complementary feedings. The results found contributed to Dr. Shreve’s research on childhood obesity in the Northwest Arkansas population and to the knowledge of parental education with ...


Effect Of Varying Rumen Degradable And Undegradable Protein On Milk Production And Nitrogen Efficiency In Lactating Dairy Cows Under Summer Conditions, Jeffrey D. Kaufman 2016 University of Tennessee, Knoxville

Effect Of Varying Rumen Degradable And Undegradable Protein On Milk Production And Nitrogen Efficiency In Lactating Dairy Cows Under Summer Conditions, Jeffrey D. Kaufman

Masters Theses

The objective is to determine the effect of reducing nitrogen input through feeding low rumen degradable protein (RDP) and rumen undegradable protein (RUP) proportions on milk production, nitrogen efficiency and metabolism in heat-stressed cows. Forty-eight mid-lactating, Holstein cows were assigned to treatments using a randomized block design in a 2x2 factorial arrangement of treatments (n = 12/treatment). Treatments included two levels of RDP (10 and 8%) and two levels of RUP (8 and 6%). From d 1 to 21, a common diet (10% RDP-8% RUP) was fed to cows followed with their respective treatment diets fed from d 22 to ...


Investigating The Relationship Among Sleep, Stress, And Body Mass Index In At-Risk First-Year College Students, Grace A. Violette 2016 University of Maine

Investigating The Relationship Among Sleep, Stress, And Body Mass Index In At-Risk First-Year College Students, Grace A. Violette

Electronic Theses and Dissertations

The study objective was to investigate relationships among body mass index (BMI), sleep quality/duration, and perceived stress in 1,176 first semester college students who enrolled in Get Fruved, an 8-state social marketing intervention to prevent unwanted weight gain. Research was limited to first-year college students at-risk for unwanted weight gain. Eligibility was based on self-report of inadequate fruit and vegetable intake and subjects meeting one or more health-risk criteria (e.g., high BMI). Students (mean age=181 years; 65% white) completed physical measurements and an online survey, including the Pittsburgh Sleep Quality Index (PSQI) (score range 0-21; ˃5 ...


Preparing For Effective Program Dissemination And Implementation: An Analysis Of Problems And Proposals For The Icook 4-H Program, Jodi L. Randall 2016 University of Maine - Main

Preparing For Effective Program Dissemination And Implementation: An Analysis Of Problems And Proposals For The Icook 4-H Program, Jodi L. Randall

Electronic Theses and Dissertations

While much effort has gone into the creation of obesity prevention programs like iCook 4-H, such programs remain largely under-utilized. The disconnect between research and practice highlights the necessity of dissemination and implementation strategies to ensure programs become adopted into practice. Creating a well-informed systematic approach to implementation will ensure that the iCook 4-H program will be implemented efficaciously and sustainably to improve the health of generations to come. The goal of this research was to implement the pilot dissemination and describe the findings in the context of the Quality Implementation Framework. The objectives were to report outcomes of the ...


Exploring The Connection Between Community Food Security Initiatives And Social-Cognitive Factors On Dietary Intake, Diana Cuy Castellanos, Josh Keller, Emma Majchrzak 2016 University of Dayton

Exploring The Connection Between Community Food Security Initiatives And Social-Cognitive Factors On Dietary Intake, Diana Cuy Castellanos, Josh Keller, Emma Majchrzak

Diana Cuy Castellanos

Food insecurity and poor dietary consumption continue to impact low-income populations in the U.S. However, communities are developing ways to address it at the local level. Community Food Security Initiatives (CFSI) focus on increasing a sustainable, healthy food supply and food system while addressing food insecurity and dietary quality within a community.

The purpose of this study was two-fold: (1) explore CFSIs in low-income areas in a metropolitan Midwest city and (2) examine the effects of the initiatives along with other social-cognitive factors on fruit and vegetable consumption in persons participating in local CFSIs.

This was a mixed-methods study ...


The Prevalence And Practice Impact Of Weight Bias Amongst Australian Dietitians, Tara Diversi, Roger Hughes, K J. Burke 2016 Bond University

The Prevalence And Practice Impact Of Weight Bias Amongst Australian Dietitians, Tara Diversi, Roger Hughes, K J. Burke

Faculty of Health Sciences & Medicine Publications

Objectives

This study explored weight bias amongst Australian Accredited Practising Dietitians (APDs) and the effect of client weight status on dietetic practice.

Methods

Participants were 201 APDs, recruited using purposive sampling. A self-administered questionnaire, the fat phobia scale (FPS), was completed to assess explicit weight bias. Participants were then randomized to receive either a female within the healthy weight range or female with obesity, accompanied by an identical case study for a condition unrelated to weight. Participants assessed the client based on data provided, provided recommendations and rated their perception of the client.

Results

Mean FPS scores indicated mild fat ...


Food Cost And Nutrient Availability In Urban Indonesia: Estimates For Food Policy Analysis, Tesfaye Teklu, Helen H. Jensen 2016 International Food Policy Research Institute

Food Cost And Nutrient Availability In Urban Indonesia: Estimates For Food Policy Analysis, Tesfaye Teklu, Helen H. Jensen

Helen Jensen

Evaluating the effects of economic growth and the effectiveness of targeted government intervention requires identification of tarket groups and information on food and nutrient consumption patterns. A model of nutrient consumption linked to food choice behaviour is used to evaluate nutrient availability in urban Indonesia. Nutrient demand responses varied significantly across income levels


Early Nutritional Programming To Enhance The Utilization Of Plant Based Diets In Fish (Largemouth Bass, Micropterus Salmoides), Maya Rene Jackson, Amit Kumar Yadav, Waldemar Rossi 2016 Kentucky State University

Early Nutritional Programming To Enhance The Utilization Of Plant Based Diets In Fish (Largemouth Bass, Micropterus Salmoides), Maya Rene Jackson, Amit Kumar Yadav, Waldemar Rossi

Posters-at-the-Capitol

Aquaculture has been the fastest growing animal food-producing sector for over half a century. Sustainable aquaculture should include replacement of fish-based feed sources by plant-based ingredients. However, this approach is often impeded by poor growth in carnivorous fish such as largemouth bass (LMB, Micropterus salmoides) fed high levels of plant-based protein. Therefore, our overall goal of the present work was to develop alternative methods of utilizing the plant-based diets (PBD) for sustainable LMB production. When fish is exposed to PBD early in their life, they may accept them more efficiently at later stages (so called Nutritional Programing, NP). Therefore, we ...


Higher Unsaturated Fatty Acid Intake And Aerobic Training Are Related With Lower Intramyocellular Lipid In Older Adults, Hillary D. McLean 2016 University of Kentucky

Higher Unsaturated Fatty Acid Intake And Aerobic Training Are Related With Lower Intramyocellular Lipid In Older Adults, Hillary D. Mclean

Posters-at-the-Capitol

Title: Higher Unsaturated Fatty Acid Intake and Aerobic Training are Related to Lower Intramyocellular Lipid in Older Adults

1Hillary McLean, 2Maja Redzic, and 3D. Travis Thomas

Department: 1Department of Agriculture, 2Department of Pharmacology and Nutritional Sciences, and 3Department of Clinical Sciences

Funding: R21AG046762-01A1, UL1TR000117, T32DK007778-16

Word Count: 298/300

Intramyocellular lipid (IMCL) is associated with metabolic dysfunction in aging. Exercise is known to influence IMCL accumulation and was recently observed to have a direct association with vitamin D status (25(OH)D) in our lab. In addition, we observed an inverse association between IMCL ...


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