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Dmk_Dissertation_11.19.18.Pdf, Dana King 2018 Washington University in St. Louis

Dmk_Dissertation_11.19.18.Pdf, Dana King

Dana King

No abstract provided.


Dmk_Dissertation_11.19.18.Pdf, Dana King 2018 Washington University in St. Louis

Dmk_Dissertation_11.19.18.Pdf, Dana King

Dana King

No abstract provided.


Rediscovery Of Red Wolf Ghost Alleles In Canid Population Along The American Gulf Coast, Elizabeth Heppenheimer, Kristin Brzeski, Ron Wooten, William Waddell, Linda Y. Rutledge, Michael J. Chamberlain, et. al. 2018 Princeton University

Rediscovery Of Red Wolf Ghost Alleles In Canid Population Along The American Gulf Coast, Elizabeth Heppenheimer, Kristin Brzeski, Ron Wooten, William Waddell, Linda Y. Rutledge, Michael J. Chamberlain, Et. Al.

School of Forest Resources and Environmental Science Publications

Rediscovering species once thought to be extinct or on the edge of extinction is rare. Red wolves have been extinct along the American Gulf Coast since 1980, with their last populations found in coastal Louisiana and Texas. We report the rediscovery of red wolf ghost alleles in a canid population on Galveston Island, Texas. We analyzed over 7000 single nucleotide polymorphisms (SNPs) in 60 canid representatives from all legally recognized North American Canis species and two phenotypically ambiguous canids from Galveston Island. We found notably high Bayesian cluster assignments of the Galveston canids to captive red wolves with extensive sharing ...


Enabling Study Of Human Immune Dysfunction Using Yeast Gene 0st3/Ungi, Ariyanna Casey 2018 Marian University - Indianapolis

Enabling Study Of Human Immune Dysfunction Using Yeast Gene 0st3/Ungi, Ariyanna Casey

Undergraduate Research Symposium (URS)

OST3 is a yeast gene for Obligosaccharyl transferase, a homolog of the Magnesium Transport 1 gene in humans. This human gene produce XMEN disease. XMEN disease is an X-Linked immune system deficiency where the amount of CD4+ T cells present in the body are reduced in function. XMEN is caused by a mutation in the MAGT1 gene. The MAGT1 gene produces a protein called magnesium transport. As shown in Magnesium transport is important because it activates CD4+ T cells, allowing for infections to be effectively detected. A mutation in the MAGT1 gene, reduces the function and effectivity of CD4+ T ...


Population Genomic Analysis Of North American Eastern Wolves (Canic Lycaon) Support Their Conservation Priority Status, Elizabeth Heppenheimer, Ryan Harrigan, Linda Rutledge, Klaus-Peter Koepfli, Alexandra L. DeCandia, Kristin Brzeski, et. al. 2018 Princeton University

Population Genomic Analysis Of North American Eastern Wolves (Canic Lycaon) Support Their Conservation Priority Status, Elizabeth Heppenheimer, Ryan Harrigan, Linda Rutledge, Klaus-Peter Koepfli, Alexandra L. Decandia, Kristin Brzeski, Et. Al.

School of Forest Resources and Environmental Science Publications

The threatened eastern wolf is found predominantly in protected areas of central Ontario and has an evolutionary history obscured by interbreeding with coyotes and gray wolves, which challenges its conservation status and subsequent management. Here, we used a population genomics approach to uncover spatial patterns of variation in 281 canids in central Ontario and the Great Lakes region. This represents the first genome-wide single nucleotide polymorphism (SNP) dataset with substantial sample sizes of representative populations. Although they comprise their own genetic cluster, we found evidence of eastern wolf dispersal outside of the boundaries of protected areas, in that the frequency ...


Genetic And Epigenetic Investigations On Pulmonary Hypertension Syndrome In Meat Type- Chickens, Khaloud Alzahrani 2018 University of Arkansas, Fayetteville

Genetic And Epigenetic Investigations On Pulmonary Hypertension Syndrome In Meat Type- Chickens, Khaloud Alzahrani

Theses and Dissertations

This dissertation presents a collection of studies that investigate the genetic and epigenetic associations to ascites phenotype in broiler chickens. Ascites is a significant metabolic disease associated with fast-growing meat-type chickens (broilers) and is a terminal result of pulmonary hypertension syndrome PHS. It is a multi-factorial syndrome caused by interactions between genetic, physiological, environmental, and managemental factors. It was estimated that ascites accounts for losses of about US$1 billion annually worldwide and for over 25% of broilers mortality. Although traditional and molecular genetic methods in the selection and in performance improvements, has greatly reduced ascites frequency, yet it has ...


Generation And Evaluation Of Modified Opaque-2 (O2) Popcorn Suggests A Route To Quality Protein Popcorn (Qpp), Ying Ren 2018 University of Nebraska-Lincoln

Generation And Evaluation Of Modified Opaque-2 (O2) Popcorn Suggests A Route To Quality Protein Popcorn (Qpp), Ying Ren

Theses, Dissertations, and Student Research in Agronomy and Horticulture

I have been working on a Quality Protein Popcorn breeding project where QPM conversion is carried out simultaneously for several elite popcorn germplasms. During my study in the graduate program, I led the following aspects of the Quality Protein Popcorn Breeding Project:

1. Identified suitable QPMs as opaque-2 allele donors.

2.Examined the feasibility of quick introgression of the opaque-2 allele into popcorn lines via marker-assisted selection.

3. Monitored modification by SDS-PAGE zein profiling and light box phenotypic selection to make sure multiple modifier loci for opaque-2 were incorporated each time generation advancement was carried out.

4. Carried out high ...


Temperature And Polyunsaturated Fatty Acid’S Effect On Daphnia Magna Reproduction, Mark Albright 2018 East Tennessee State University

Temperature And Polyunsaturated Fatty Acid’S Effect On Daphnia Magna Reproduction, Mark Albright

Electronic Theses and Dissertations

Organisms adapt to their environments by adjusting their biochemistry and physiology; such adaptation is limited by resource availability and physiological constraints. The freshwater crustacean Daphnia magna inhabits a wide range of environments and must survive and reproduce within a range of temperatures. One limit to low-temperature adaptation is thought to be the availability of unsaturated fatty acids necessary to maintain proper fluidity of cellular membranes. D. magna maintained at 10 ºC on a diet poor in unsaturated fatty acids have been observed to produce clutches that fail to develop. However, this has not been observed on a diet rich in ...


Insights Into The Evolution Of The New World Diploid Cottons (Gossypium, Subgenus Houzingenia) Based On Genome Sequencing, Corrinne E. Grover, Mark A. Arick II, Adam Thrash, Justin L. Conover, William S. Sanders, Daniel G. Peterson, James E. Frelichowski, Jodi A. Scheffler, Brian E. Scheffler, Jonathan F. Wendel 2018 Iowa State University

Insights Into The Evolution Of The New World Diploid Cottons (Gossypium, Subgenus Houzingenia) Based On Genome Sequencing, Corrinne E. Grover, Mark A. Arick Ii, Adam Thrash, Justin L. Conover, William S. Sanders, Daniel G. Peterson, James E. Frelichowski, Jodi A. Scheffler, Brian E. Scheffler, Jonathan F. Wendel

Ecology, Evolution and Organismal Biology Publications

We employed phylogenomic methods to study molecular evolutionary processes and phylogeny in the geographically widely dispersed New World diploid cottons (Gossypium, subg. Houzingenia). Whole genome resequencing data (average of 33X genomic coverage) were generated to reassess the phylogenetic history of the subgenus and provide a temporal framework for its diversification. Phylogenetic analyses indicate that the subgenus likely originated following trans-oceanic dispersal from Africa about 6.6 mya, but that nearly all of the biodiversity evolved following rapid diversification in the mid-Pleistocene (0.5-2.0 mya), with multiple long-distance dispersals required to account for range expansion to Arizona, the Galapagos Islands ...


Thinking Computationally About Forensics: Anthropological Perspectives On Advancements In Technologies, Data, And Algorithms, Bridget F.B. Algee-Hewitt, Jieun Kim, Cris E. Hughes 2018 Stanford University

Thinking Computationally About Forensics: Anthropological Perspectives On Advancements In Technologies, Data, And Algorithms, Bridget F.B. Algee-Hewitt, Jieun Kim, Cris E. Hughes

Human Biology Open Access Pre-Prints

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New Approaches To Juvenile Age Estimation In Forensics: Application Of Transition Analysis Via The Shackelford Et Al. Method To A Diverse Modern Subadult Sample, Kelly R. Kamnikar, Nicholas P. Herrmann, Amber M. Plemons 2018 Michigan State University

New Approaches To Juvenile Age Estimation In Forensics: Application Of Transition Analysis Via The Shackelford Et Al. Method To A Diverse Modern Subadult Sample, Kelly R. Kamnikar, Nicholas P. Herrmann, Amber M. Plemons

Human Biology Open Access Pre-Prints

Dental development is one of the most widely utilized and accurate methods available for estimating age in subadult skeletal remains. The timing of tooth growth and development is regulated by genetics and less affected by external factors, allowing reliable estimates of chronological age. Traditional methodology focuses on comparing tooth developmental scores to corresponding age charts. Using the Moorrees, Fanning, and Hunt (MFH) developmental scores, Shackelford and colleagues embed the dental development method in a statistical framework based on transition analysis. They generated numerical parameters underlining each “stage” and age-at-death distribution and applied them to fossil hominins and Neanderthals with limited ...


Who Needs Data? I’Ve Got Experience!, Dawnie Wolfe Steadman 2018 University of Tennessee, Knoxville

Who Needs Data? I’Ve Got Experience!, Dawnie Wolfe Steadman

Human Biology Open Access Pre-Prints

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Human Genetic Intervention: How Far Should We Go?, Lance Gregory A. Nunes 2018 University of Hawaiʻi at Mānoa

Human Genetic Intervention: How Far Should We Go?, Lance Gregory A. Nunes

Mānoa Horizons

Since the beginning of time, man has treated illness and disease with natural remedies. With the advancement in knowledge and technology, new kinds of treatments have entered the realm of medicine—namely genetic intervention. This paper aims to help determine where we should take our development of this technology. In each branch of genetic intervention—whether it be gene therapy, prevention, remediation, or enhancement—issues of ethics, socio-economics, and religion have casted a cloud over the technology, hindering its progression. In contrary, the power to improve the quality and save the lives of individuals affected by genetic diseases does not ...


Gene Therapy: An Overview Of Approaches And Issues, Tony Head 2018 University of Hawaiʻi at Mānoa

Gene Therapy: An Overview Of Approaches And Issues, Tony Head

Mānoa Horizons

For over 25 years, scientists have been researching and testing gene therapy techniques, but this work has only resulted in a single FDA-approved therapy: Kymriah™ from Novartis. Kymriah™ was approved in the U.S. in August 2017, and genetically modifies a patient’s own immune cells to seek out and destroy abnormal blood cells. Although clinical trials continue to test and refine different gene therapy approaches, understanding and evaluating the risks associated with treatment may be overwhelming to patients and caregivers alike. This article attempts to provide readers with an introduction to gene therapy so that anyone considering treatment or ...


Who Owns Our Genes?, Julia Fujisaka 2018 University of Hawaiʻi at Mānoa

Who Owns Our Genes?, Julia Fujisaka

Mānoa Horizons

In June of 2013, the United States Supreme Court ruled 9-0 in favor of the American Civil Liberties Union (ACLU) and others in a case arguing against the patentability of human genes. Critics of gene patenting had long suggested that instead of promoting innovation, human gene patents posed a significant roadblock to the development of important diagnostics and therapeutics, and had a negative impact on public health. Myriad Genetics, Inc., the opposing party, argued that the patenting of human genes encouraged researchers and scientists to try to find alternate paths to reach end goals. However, Myriad Genetics strictly defended patents ...


Exposure To Herbicide Is Linked To Elevated Homocysteine And Folic Acid Deficiency, Tony Head, Julia Fujisaka, Jasmine Padamada, Steffanie Sobitz 2018 University of Hawaiʻi at Mānoa

Exposure To Herbicide Is Linked To Elevated Homocysteine And Folic Acid Deficiency, Tony Head, Julia Fujisaka, Jasmine Padamada, Steffanie Sobitz

Mānoa Horizons

SciFiToxin (SFT) is the active ingredient in a popular non-selective herbicide, RoundUpTM. Introduced in 2020, SFT obtained regulatory approval for general use and has since become the leading residential and agricultural herbicide, especially among farmers of genetically modified (GM) crops. Results from two recent studies indicate a rise in the average homocysteine level in humans worldwide and implicate SFT as a possible cause for this phenomenon as well as folic acid deficiency, due to SFT’s effect on key enzymes in the body. Elevated homocysteine levels in the blood may lead to a number of life-threatening conditions, and folic acid ...


The Right To Know: Should Gmo Labeling Be Mandatory In The U.S.?, Steffanie Sobitz 2018 University of Hawaiʻi at Mānoa

The Right To Know: Should Gmo Labeling Be Mandatory In The U.S.?, Steffanie Sobitz

Mānoa Horizons

From the commercial release of the first successful genetically modified food to the current debate about the safety of GM foods, one issue has stayed on the forefront of consumers’ minds: the right to know what is in our food. While the history of genetically modified products is easy to follow, the arguments surrounding these high-tech consumables have become convoluted at best. One of the most prominent issues regarding GM foods is the argument that companies who produce, grow, market and sell genetically modified foodstuffs should be required to label them as such. Some iterate the right to know what ...


Speciation And Hybridization In Jamaican-Endemic Streamertail Hummingbirds (Trochilus Polytmus And T. Scitulus), Caroline D. Judy 2018 Louisiana State University and Agricultural and Mechanical College

Speciation And Hybridization In Jamaican-Endemic Streamertail Hummingbirds (Trochilus Polytmus And T. Scitulus), Caroline D. Judy

LSU Doctoral Dissertations

Streamertails hummingbirds (Trochilus polytmus and T. scitulus) are recently diverged sister taxa that appear to have speciated in situ on the island of Jamaica. They are distinguished by male bill color, a secondary sexual trait that is coral red in T. polytmus and jet black in T. scitulus. They hybridize in a narrow zone where their ranges meet in eastern Jamaica. In Chapter 2, I performed a formal population survey of T. scitulus to determine the size of the population, which was unknown. I determined that the total population contains well over 100,000 individuals despite its limited geographic range ...


How Does Antibiotic Resistance Spread In Tuberculosis?, Julie A. Spencer 2018 University of New Mexico - Main Campus

How Does Antibiotic Resistance Spread In Tuberculosis?, Julie A. Spencer

Shared Knowledge Conference

The ancient bacterial disease of tuberculosis (TB) is curable with antibiotics, but according to the World Health Organization, in 2016 over 10 million people became infected with the disease. 600,000 of these cases were resistant to antibiotics, yet the worldwide treatment success rate for drug resistant TB is only 54%. Furthermore, strains exist now that are resistant to all known antibiotics. In the current environment of global travel, this poses a risk for emergent epidemics of drug resistant TB. In this study, I asked: after an antibiotic resistant strain has evolved in someone’s lungs, how does it spread ...


Mechanisms For The Spread Of Antibiotic Resistance In Tuberculosis, Julie Allison Spencer 2018 University of New Mexico - Main Campus

Mechanisms For The Spread Of Antibiotic Resistance In Tuberculosis, Julie Allison Spencer

Shared Knowledge Conference

Tuberculosis (TB) is currently the ninth leading cause of death for humans worldwide, causing 10.4 million new infections in 2016. According to the World Health Organization, of these infections, 600,000 were antibiotic resistant. However, the treatment success rate for resistant TB was only 54%. The potential for emergent epidemics of drug resistant TB highlights the need to understand the mechanisms for the spread of resistance. Mycobacterium tuberculosis, the bacterium that causes TB, evolves resistant strains within individuals who are being treated with antibiotics. It has been assumed previously that the resistant characteristics of these strains are spread primarily ...


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