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Mamba Juice: Expression Of Exogenous Mambalgin Peptide Using The Pgapzα Vector System, Lydia Studdard, Kristin VanMouwerik, Merhawi Yigzaw, Reza Alavi 2014 Georgia State University

Mamba Juice: Expression Of Exogenous Mambalgin Peptide Using The Pgapzα Vector System, Lydia Studdard, Kristin Vanmouwerik, Merhawi Yigzaw, Reza Alavi

Georgia State Undergraduate Research Conference

No abstract provided.


Development Of A Tetracycline-Inducible Expression System For Crithidia Fasciculata, Mariela Garcia, Enic Nguyen 2014 Georgia State University

Development Of A Tetracycline-Inducible Expression System For Crithidia Fasciculata, Mariela Garcia, Enic Nguyen

Georgia State Undergraduate Research Conference

No abstract provided.


The Roles Of Hedgehog And Ap-2 Signaling In The Regulation Of Lens Development, Christine L. Kerr 2014 McMaster University

The Roles Of Hedgehog And Ap-2 Signaling In The Regulation Of Lens Development, Christine L. Kerr

Open Access Dissertations and Theses

Lens development is an intricate process governed by growth factor signaling and a hierarchy of transcription factors that regulate important processes required for normal lens development.

Midline hedgehog (Hh) signaling has been implicated in lens defects including cyclopia and lens degeneration in rodents and fish. A lens specific model of hedgehog signaling has not been examined, and it was unknown whether the lens is able to respond to Hh signals. To investigate this question, and to determine any consequences of abnormal Hh signaling on lens development, a mouse model of constitutively active smoothened in the surface ectoderm and derivatives, (including ...


Cyb5d2 Possesses Tumour Suppressing Activities, Yen Ting Shen 2014 McMaster University

Cyb5d2 Possesses Tumour Suppressing Activities, Yen Ting Shen

Open Access Dissertations and Theses

Loss of chromosome 17p is frequently observed in various cancers. One of the most commonly mutated targets p53 is on chromosome 17p13.1. However, studies have also reported loss of the 17p13.2 region in breast and medulloblastoma, thereby suggesting the residence of potential tumour suppressors in 17p13.2. Cytochrome b5 domain containing 2 (CYB5D2) is located on 17p13.2 implying CYB5D2 being a candidate tumour suppressor. CYB5D2 (neuferricin) belongs to the family of membrane associated progesterone receptors (MAPR). The archetypal member of the family, progesterone receptor membrane component 1 (PGRMC1), has been shown to play a role in domains ...


Redox Regulation Of Protein Translation In Eukaryotes, Maxim Gerashchenko 2014 University of Nebraska - Lincoln

Redox Regulation Of Protein Translation In Eukaryotes, Maxim Gerashchenko

Theses and Dissertations in Biochemistry

Gene expression may be controlled at multiple levels, e.g., through genomic architecture, transcription and translation. In the current work, we focused on regulation of protein synthesis. Historically, the investigation of the regulation of gene expression at the level of translation lagged behind the transcriptional control because of the lack of accessible high-throughput methods. Our research has begun with the finding of the use of alternative non-AUG start codon in thioredoxin-glutathione reductase (TGR), a selenoprotein involved in redox control during male reproduction. The use of this codon, CUG, relies on the Kozak consensus sequence and ribosomal scanning mechanism. However, the ...


Responsible Integration Of Biological And Psychosocial Models: Comments On “Genetic Associations With Intimate Partner Violence In A Sample Of Hazardous Drinking Men In Batterer Intervention Programs”, Antonia Abbey 2014 Wayne State University

Responsible Integration Of Biological And Psychosocial Models: Comments On “Genetic Associations With Intimate Partner Violence In A Sample Of Hazardous Drinking Men In Batterer Intervention Programs”, Antonia Abbey

Psychology Faculty Research Publications

Despite research demonstrating that gene expression differs in response to social environmental circumstances, deterministic views of biology are common. Stuart and colleagues (this issue) encourage readers to think about genetic factors in the same dynamic and probabilistic manner that they consider other causes of intimate partner violence. Given that participants had co-occurring alcohol problems, future studies should evaluate how different genetic polymorphisms uniquely and synergistically contribute to heavy drinking and aggression under different socio-environmental conditions. Psychological expectancies have a powerful impact on behavior, thus extreme caution is required before labeling people as genetically predisposed to violence.


The Experience Of Having Primary Caregiving Responsibilities For An Adult Sibling With Down Syndrome, Patricia Sciscione 2014 Seton Hall University

The Experience Of Having Primary Caregiving Responsibilities For An Adult Sibling With Down Syndrome, Patricia Sciscione

Seton Hall University Dissertations and Theses (ETDs)

Abstract

Background: The current generation of adults with Down syndrome is living longer and is likely to outlive their parents. Siblings have been identified as the likely future caregivers for adults with Down syndrome, yet little is known about what the experience is like for those who are currently caring for their siblings. It is necessary to gain an understanding of what the service needs are for this population in order to assist sibling caregivers.

Objectives: To explore and describe the experience of being an adult who is partially or fully involved with primary caregiving responsibilities for a sibling with ...


The Effect Of Smoking On Dna Methylation Of Peripheral Blood Mononuclear Cells From African American Women, Meeshanthini V. Dogan, Bridget Shields, Carolyn E. Cutrona, Long Gao, Frederick X. Gibbons, Ronald Simons, Martha Monick, Gene H. Brody, Kai Tan, Steven R. H. Beach, Robert A. Philibert 2014 Iowa State University

The Effect Of Smoking On Dna Methylation Of Peripheral Blood Mononuclear Cells From African American Women, Meeshanthini V. Dogan, Bridget Shields, Carolyn E. Cutrona, Long Gao, Frederick X. Gibbons, Ronald Simons, Martha Monick, Gene H. Brody, Kai Tan, Steven R. H. Beach, Robert A. Philibert

Psychology Publications and Papers

Background

Regular smoking is associated with a wide variety of syndromes with prominent inflammatory components such as cancer, obesity and type 2 diabetes. Heavy regular smoking is also associated with changes in the DNA methylation of peripheral mononuclear cells. However, in younger smokers, inflammatory epigenetic findings are largely absent which suggests the inflammatory response(s) to smoking may be dose dependent. To help understand whether peripheral mononuclear cells have a role in mediating these responses in older smokers with higher cumulative smoke exposure, we examined genome-wide DNA methylation in a group of well characterized adult African American subjects informative for ...


Arf4 Is Required For Mammalian Development But Dispensable For Ciliary Assembly, John A. Follit, Jovenal T. San Agustin, Julie A. Jonassen, Tingting Huang, Jaime A. Rivera-Perez, Kimberly D. Tremblay, Gregory J. Pazour 2014 University of Massachusetts Medical School

Arf4 Is Required For Mammalian Development But Dispensable For Ciliary Assembly, John A. Follit, Jovenal T. San Agustin, Julie A. Jonassen, Tingting Huang, Jaime A. Rivera-Perez, Kimberly D. Tremblay, Gregory J. Pazour

GSBS Student Publications

The primary cilium is a sensory organelle, defects in which cause a wide range of human diseases including retinal degeneration, polycystic kidney disease and birth defects. The sensory functions of cilia require specific receptors to be targeted to the ciliary subdomain of the plasma membrane. Arf4 has been proposed to sort cargo destined for the cilium at the Golgi complex and deemed a key regulator of ciliary protein trafficking. In this work, we show that Arf4 binds to the ciliary targeting sequence (CTS) of fibrocystin. Knockdown of Arf4 indicates that it is not absolutely required for trafficking of the fibrocystin ...


An Improved Predictive Recognition Model For Cys2-His2 Zinc Finger Proteins, Ankit Gupta, Ryan G. Christensen, Heather A. Bell, Mathew Goodwin, Ronak Y. Patel, Manishi Pandey, Metewo Selase Enuameh, Amy L. Rayla, Cong Zhu, Stacey Thibodeau-Beganny, Michael H. Brodsky, J. Keith Joung, Scot A. Wolfe, Gary D. Stormo 2014 University of Massachusetts Medical School

An Improved Predictive Recognition Model For Cys2-His2 Zinc Finger Proteins, Ankit Gupta, Ryan G. Christensen, Heather A. Bell, Mathew Goodwin, Ronak Y. Patel, Manishi Pandey, Metewo Selase Enuameh, Amy L. Rayla, Cong Zhu, Stacey Thibodeau-Beganny, Michael H. Brodsky, J. Keith Joung, Scot A. Wolfe, Gary D. Stormo

Program in Gene Function and Expression Publications and Presentations

Cys2-His2 zinc finger proteins (ZFPs) are the largest family of transcription factors in higher metazoans. They also represent the most diverse family with regards to the composition of their recognition sequences. Although there are a number of ZFPs with characterized DNA-binding preferences, the specificity of the vast majority of ZFPs is unknown and cannot be directly inferred by homology due to the diversity of recognition residues present within individual fingers. Given the large number of unique zinc fingers and assemblies present across eukaryotes, a comprehensive predictive recognition model that could accurately estimate the DNA-binding specificity of any ZFP based on ...


Epicatechin Stimulates Mitochondrial Activity And Selectively Sensitizes Cancer Cells To Radiation, Hosam A. Elbaz, Icksoo Lee, Deborah A. Antwih, Jenney Liu, Maik Hüttemann, Steven P. Zielske 2014 Wayne State University

Epicatechin Stimulates Mitochondrial Activity And Selectively Sensitizes Cancer Cells To Radiation, Hosam A. Elbaz, Icksoo Lee, Deborah A. Antwih, Jenney Liu, Maik Hüttemann, Steven P. Zielske

Center for Molecular Medicine and Genetics

Radiotherapy is the treatment of choice for solid tumors including pancreatic cancer, but the effectiveness of treatment is limited by radiation resistance. Resistance to chemotherapy or radiotherapy is associated with reduced mitochondrial respiration and drugs that stimulate mitochondrial respiration may decrease radiation resistance. The objectives of this study were to evaluate the potential of (-)-epicatechin to stimulate mitochondrial respiration in cancer cells and to selectively sensitize cancer cells to radiation. We investigated the natural compound (-)-epicatechin for effects on mitochondrial respiration and radiation resistance of pancreatic and glioblastoma cancer cells using a Clark type oxygen electrode, clonogenic survival assays, and ...


Computational Model For Survey And Trend Analysis Of Patients With Endometriosis : A Decision Aid Tool For Ebm, Salvo Reina, Vito Reina, Franco Ameglio, Mauro Costa, Alessandro Fasciani 2014 COBRA

Computational Model For Survey And Trend Analysis Of Patients With Endometriosis : A Decision Aid Tool For Ebm, Salvo Reina, Vito Reina, Franco Ameglio, Mauro Costa, Alessandro Fasciani

COBRA Preprint Series

Endometriosis is increasingly collecting worldwide attention due to its medical complexity and social impact. The European community has identified this as a “social disease”. A large amount of information comes from scientists, yet several aspects of this pathology and staging criteria need to be clearly defined on a suitable number of individuals. In fact, available studies on endometriosis are not easily comparable due to a lack of standardized criteria to collect patients’ informations and scarce definitions of symptoms. Currently, only retrospective surgical stadiation is used to measure pathology intensity, while the Evidence Based Medicine (EBM) requires shareable methods and correct ...


Selection And Phenotypic Characterization Of A Core Collection Of Brachypodium Distachyon Inbred Lines, Ludmilla Tyler, Johnathan U. Fangel, Alexandra D. Fagerström, Michael A. Steinwand, Ted K. Raab, William GT Willats, John P. Vogel 2014 SelectedWorks

Selection And Phenotypic Characterization Of A Core Collection Of Brachypodium Distachyon Inbred Lines, Ludmilla Tyler, Johnathan U. Fangel, Alexandra D. Fagerström, Michael A. Steinwand, Ted K. Raab, William Gt Willats, John P. Vogel

Ted K. Raab

The model grass Brachypodium distachyon is increasingly used to study various aspects of grass biology. A large and genotypically diverse collection of B. distachyon germplasm has been assembled by the research community. The natural variation in this collection can serve as a powerful experimental tool for many areas of inquiry, including investigating biomass traits. We surveyed the phenotypic diversity in a large collection of inbred lines and then selected a core collection of lines for more detailed analysis with an emphasis on traits relevant to the use of grasses as biofuel and grain crops. Phenotypic characters examined included plant height ...


Transcription Factor Binding To Caenorhabditis Elegans First Introns Reveals Lack Of Redundancy With Gene Promoters, Juan I. Fuxman Bass, Alex M. Tamburino, Akihiro Mori, Nathan Beittel, Matthew T. Weirauch, John S. Reece-Hoyes, Albertha J. M. Walhout 2014 University of Massachusetts Medical School

Transcription Factor Binding To Caenorhabditis Elegans First Introns Reveals Lack Of Redundancy With Gene Promoters, Juan I. Fuxman Bass, Alex M. Tamburino, Akihiro Mori, Nathan Beittel, Matthew T. Weirauch, John S. Reece-Hoyes, Albertha J. M. Walhout

Program in Systems Biology Publications and Presentations

Gene expression is controlled through the binding of transcription factors (TFs) to regulatory genomic regions. First introns are longer than other introns in multiple eukaryotic species and are under selective constraint. Here we explore the importance of first introns in TF binding in the nematode Caenorhabditis elegans by combining computational predictions and experimentally derived TF-DNA interaction data. We found that first introns of C. elegans genes, particularly those for families enriched in long first introns, are more conserved in length, have more conserved predicted TF interactions and are bound by more TFs than other introns. We detected a significant positive ...


The Evolutionary Dynamics Of Transcription Factors, Operators, And Their Target Genes Across Prokaryotes, Marc del Grande 2014 Wilfrid Laurier University

The Evolutionary Dynamics Of Transcription Factors, Operators, And Their Target Genes Across Prokaryotes, Marc Del Grande

Theses and Dissertations (Comprehensive)

In prokaryotes, transcriptional regulation commonly involves a transcription factor (TF) binding to a particular conserved sequence of nucleotides (operator). Binding elicits a transcriptional response, either activation or repression. The evolution of gene regulation has been identified as a primary driver of species diversity, making it an important area of research. This work examined the dynamics of the interactions between TFs and operators, and TFs and their primary target genes in attempt to assess the rapid evolution of transcriptional regulatory networks (TRNs) across a diverse set of prokaryotes. Using software packages, operator sequences from Escherichia coli K12 were compared to every ...


The Role Of Body Size On The Outcome Of Mating Interactions In Drosophila Melanogaster, Adam C. Lounsbury 2014 Wilfrid Laurier University

The Role Of Body Size On The Outcome Of Mating Interactions In Drosophila Melanogaster, Adam C. Lounsbury

Theses and Dissertations (Comprehensive)

Sexual selection is the process by which some individuals produce more and/or better quality offspring than others because they are better at securing mates. While this may be accomplished by defeating same-sex rivals (intrasexual selection), individuals of one sex (typically females) may also “decide” on the suitability of individuals of the opposite sex (typically males), resulting in intersexual selection on attractive traits. While a great deal of scrutiny has focused on how sexual selection influences male display traits, much less scrutiny has been directed toward the factors underlying female preference, including genetic variation, as well as the extent to ...


A Morphological And Genetic Analysis Of Forensically Important Blow Flies, From Georgia: The Genus Lucilia, Katie S. Googe 2014 Georgia Southern University

A Morphological And Genetic Analysis Of Forensically Important Blow Flies, From Georgia: The Genus Lucilia, Katie S. Googe

University Honors Program Theses

Identification of Blow flies (Diptera: Calliphoridae) to species is important for estimating postmortem intervals, because insect species develop at different rates. Three Blow fly species in Georgia; Lucilia coeruleiviridis, L. cuprina, and L. sericata are similar morphologically, making identification difficult. Furthermore, the status of L. cuprina is in doubt; this species may be a complex of true L. cuprina, and L. cuprina x L. sericata hybrids. The objective of this study was to survey the Georgia Blow fly community and validate the statuses of L. coeruleiviridis, L. cuprina, and L. sericata, through morphological and genetic analyses. For a representative sample ...


Bayesian Methods For Genomic Prediction And Genome-Wide Association Studies Combining Information On Genotyped And Non-Genotyped Individuals, Rohan L. Fernando, Jack C. M. Dekkers, Dorian J. Garrick 2014 Iowa State University

Bayesian Methods For Genomic Prediction And Genome-Wide Association Studies Combining Information On Genotyped And Non-Genotyped Individuals, Rohan L. Fernando, Jack C. M. Dekkers, Dorian J. Garrick

Animal Industry Report

Genomic prediction involves using high-density marker genotypes to characterize the impact on performance of every region of the genome, and using that information to predict performance of genotyped selection candidates. This is a relatively new technology and is now gaining traction in personalized medicine and in various livestock industries. Our new approach promises to overcome serious limitations with existing techniques for genomic prediction.


Genetics Of Feed Efficiency In Laying Hens, Anna Wolc, Jesus Arango, Petek Settar, Janet E. Fulton, Neil P. O'Sullivan, Rudolf Preisinger, Rohan L. Fernando, Dorian J. Garrick, Jack C. M. Dekkers 2014 Iowa State University

Genetics Of Feed Efficiency In Laying Hens, Anna Wolc, Jesus Arango, Petek Settar, Janet E. Fulton, Neil P. O'Sullivan, Rudolf Preisinger, Rohan L. Fernando, Dorian J. Garrick, Jack C. M. Dekkers

Animal Industry Report

Feed efficiency data from multiple generations of a brown egg layer line were analyzed with pedigree- and marker-based methods. Marker information improved accuracy of estimated breeding values (EBV), especially for long-term prediction. Several regions in the genome were found to be associated with feed consumption and efficiency.


Pigs Selected For Increased Feed Efficiency Are Less Affected By Experimental Infection With The Prrs Virus, Jenelle R. Dunkelberger, Nicholas Boddicker, Jennifer Young, Dinesh M. Thekkoot, Bob Rowland, Jack C. M. Dekkers 2014 Iowa State University

Pigs Selected For Increased Feed Efficiency Are Less Affected By Experimental Infection With The Prrs Virus, Jenelle R. Dunkelberger, Nicholas Boddicker, Jennifer Young, Dinesh M. Thekkoot, Bob Rowland, Jack C. M. Dekkers

Animal Industry Report

Analyses of average daily gain (ADG) and viral load (VL) suggest that selection for increased feed efficiency based on residual feed intake (RFI) does not increase the impact of Porcine Reproductive and Respiratory Syndrome (PRRS) infection on these two traits. In fact, the results show that growth of the more efficient pigs was less affected by PRRS infection than that of the inefficient line. These findings provide commercial farmers with additional incentives to invest in feed-efficient pigs.


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