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Disruption Of Synchronous Behavior In Pancreatic Islets Via Hub Cells, Janita Patwardhan 2018 University of Maryland - Baltimore County

Disruption Of Synchronous Behavior In Pancreatic Islets Via Hub Cells, Janita Patwardhan

Biology and Medicine Through Mathematics Conference

No abstract provided.


Radical Social Ecology As Deep Pragmatism: A Call To The Abolition Of Systemic Dissonance And The Minimization Of Entropic Chaos, Arielle Brender 2018 Fordham University

Radical Social Ecology As Deep Pragmatism: A Call To The Abolition Of Systemic Dissonance And The Minimization Of Entropic Chaos, Arielle Brender

Student Theses 2015-Present

This paper aims to shed light on the dissonance caused by the superimposition of Dominant Human Systems on Natural Systems. I highlight the synthetic nature of Dominant Human Systems as egoic and linguistic phenomenon manufactured by a mere portion of the human population, which renders them inherently oppressive unto peoples and landscapes whose wisdom were barred from the design process. In pursuing a radical pragmatic approach to mending the simultaneous oppression and destruction of the human being and the earth, I highlight the necessity of minimizing entropic chaos caused by excess energy expenditure, an essential feature of systems that aim ...


Effects Of Prior Fasting On Fat Oxidation During Resistance Exercise, Kendall Frawley, Gabrielle Greenwald, Rebecca R. Rogers, John K. Petrella, Mallory R. Marshall 2018 Samford University

Effects Of Prior Fasting On Fat Oxidation During Resistance Exercise, Kendall Frawley, Gabrielle Greenwald, Rebecca R. Rogers, John K. Petrella, Mallory R. Marshall

International Journal of Exercise Science

International Journal of Exercise Science 11(2): 827-833, 2018. Prior research has demonstrated that the percentage of fuel utilization contributed by CHO compared to fat rises with an increase in exercise intensity. The role of food intake prior to exercise has been well studied and fasting prior to exercise generally increases reliance on fat as fuel. However, data on the role of fasting prior to resistance exercise is limited. Therefore, the purpose of this study was to assess the effects of one bout of resistance training in a fasted state compared to ingestion of standardized meal on fat and carbohydrate ...


Behavior Of Heart Rate Variability After 10 Repetitions Maximum Load Test For Lower Limbs, Estêvão R. Monteiro, Jefferson S. Novaes, Aline G. Fiuza, Eduardo Portugal, Felipe S. Triani, Leonardo Bigio, Rudson Santos, Alexandre Palma, Victor G. Corrêa Neto 2018 Federal University of Rio de Janeiro

Behavior Of Heart Rate Variability After 10 Repetitions Maximum Load Test For Lower Limbs, Estêvão R. Monteiro, Jefferson S. Novaes, Aline G. Fiuza, Eduardo Portugal, Felipe S. Triani, Leonardo Bigio, Rudson Santos, Alexandre Palma, Victor G. Corrêa Neto

International Journal of Exercise Science

International Journal of Exercise Science 11(6): 834-843, 2018. The purpose of this study was to analyze the acute heart rate variability behavior after 10 repetitions maximum load test for back squat, leg press, leg extension, and leg flexion in normotensive subjects. Eight recreationally trained women (age: 21.8 ± 2.2 yrs; height: 167.6 ± 6.3 cm; weight: 61.6 ± 10.1 kg) performed two 10 repetitions maximum testing days with 48-hours rest between each one. Heart rate variability was measured in baseline and postexercise (15-, 30-, 45-, and 60-minutes) for time and frequency domain. A significant difference was ...


Relative Handgrip Strength As A Simple Tool To Evaluate Impaired Heart Rate Recovery And A Low Chronotropic Index In Obese Older Women, Cristiane Rocha da Silva, Dahan da Cunha Nascimento, Ivo Sousa Neto, Ramires Tibana, Samuel Oliveira, Renato Valduga, Nayara Santos, Bruno Saraiva, Jonato Prestes, Jeffrey Willardson, Guilherme Borges Pereira 2018 Programa de Pós-Graduação em Educação Física, Universidade Católica de Brasília, Brasília, Distrito Federal, Brasil.

Relative Handgrip Strength As A Simple Tool To Evaluate Impaired Heart Rate Recovery And A Low Chronotropic Index In Obese Older Women, Cristiane Rocha Da Silva, Dahan Da Cunha Nascimento, Ivo Sousa Neto, Ramires Tibana, Samuel Oliveira, Renato Valduga, Nayara Santos, Bruno Saraiva, Jonato Prestes, Jeffrey Willardson, Guilherme Borges Pereira

International Journal of Exercise Science

International Journal of Exercise Science 11(2): 844-855, 2018. The aim of the present study was to compare differences in heart rate response following a treadmill exercise test in elderly obese women categorized into groups based on relative handgrip strength. Eighty-eight obese elderly women who were between the ages of 60 and 87 participated in the study and were categorized and enrolled to one of two groups based on lower (< 1.51 m²) or higher (≥ 1.51 m²) relative handgrip strength, respectively. The heart rate recovery in the first and second minutes following the treadmill exercise test and the chronotropic index were compared between groups. The higher relative handgrip strength group presented a significantly higher peak heart rate during exercise and a quicker heart rate recovery following exercise versus the lower relative handgrip strength group (pp=0.059) toward a significantly greater chronotropic index in the higher versus the lower relative handgrip strength group. In conclusion, elderly women with greater relative handgrip strength also ...


Childhood Poverty And Its Effects On The Brain: Physiological And Functional Implications, Lauren Scandrett 2018 University of Wyoming

Childhood Poverty And Its Effects On The Brain: Physiological And Functional Implications, Lauren Scandrett

Honors Theses AY 17/18

One out of every five American children lives below the federal poverty line. Considering that poverty is deemed one of the most influential risk factors for poor developmental outcomes, it is critical to understand what effect poverty has on the developing brain and how those brain changes affect a child’s life. Poverty is chiefly defined by having a low socioeconomic status (SES), but a low SES is often accompanied by other influencers, such as nutrition and mental stimulation, termed poverty co-factors. Other poverty co-factors include, but are not limited to, maternal stress and malnutrition, environmental toxins, parental nurturance, and ...


The Impact Of An External Load Of Football Equipment On Dynamic Balance As Assessed By The Modified Star Excursion Balance Test, Thomas J. Denehy, Timothy F. Marshall, Kim Spaccarotella, Walter Andzel 2018 Kean University

The Impact Of An External Load Of Football Equipment On Dynamic Balance As Assessed By The Modified Star Excursion Balance Test, Thomas J. Denehy, Timothy F. Marshall, Kim Spaccarotella, Walter Andzel

International Journal of Exercise Science

International Journal of Exercise Science 11(4): 797-805, 2018.Ankle sprains are common injuries, especially for football players, and may result in ankle instability, which can limit performance and increase injury risk. Ankle stability return to play criteria is often assessed under loaded conditions, even though previous research suggests loaded conditions affect dynamic balance. The purpose of this study was to evaluate dynamic balance under loaded conditions. A modified Star Excursion Balance Test (SEBT), incorporating anterior, posterior medial and posterior lateral reach directions under the loaded condition of NCAA Division III football equipment was evaluated. Thirty male collegiate football players ...


The Singing Voice During The First Two Years Of Testosterone Therapy: Working With The Trans Or Gender Queer Voice, Tessa M. Romano 2018 University of Colorado Boulder

The Singing Voice During The First Two Years Of Testosterone Therapy: Working With The Trans Or Gender Queer Voice, Tessa M. Romano

Voice and Opera Graduate Theses & Dissertations

In order to better serve singers who identify as trans men or gender queer, voice teachers must understand the vocal effects of hormone replacement therapy, specifically that of testosterone therapy. Testosterone therapy is the only type of hormone replacement therapy that permanently changes the voice and eventually results in a full octave drop or more of a person’s spoken fundamental frequency. Due to such a dramatic shift, the voice change process can be turbulent.

This dissertation is designed to educate both cis gender voice teachers and trans and gender queer singers on the process of vocal change during the ...


Reliability And Validation Of The Hexoskin Wearable Bio-Collection Device During Walking Conditions, Jeffrey Montes, John C. Young, Richard D. Tandy, James W. Navalta 2018 University of Nevada, LasVegas

Reliability And Validation Of The Hexoskin Wearable Bio-Collection Device During Walking Conditions, Jeffrey Montes, John C. Young, Richard D. Tandy, James W. Navalta

International Journal of Exercise Science

International Journal of Exercise Science 11(7): 806-816, 2018. To evaluate if the Hexoskin smart shirt (HxS) would produce valid and reliable measurements for heart rate (HR), respiratory rate (RR), minute ventilation (VE), step count (SC), and energy expenditure (EE) when compared to a Polar T-31 heart rate monitor, an Applied Electrochemistry Moxus Metabolic System, and a manual step count. A two-day walking treadmill protocol with participants walking for 3 minutes at 3 speeds (1.5mph, 2.5mph, 3.5mph, 0% grade) was performed. Forty-nine volunteers participated the first day, forty-six on the second, thirty-one were used for reliability ...


Strength And Stability Analysis Of Rehabilitated Anterior Cruciate Ligament Individuals, Jeffrey J. Cervenka, Meredith Decker, Mark D. Ricard, Joshua Beaty, Logan Ruhde 2018 University of Texas at Arlington

Strength And Stability Analysis Of Rehabilitated Anterior Cruciate Ligament Individuals, Jeffrey J. Cervenka, Meredith Decker, Mark D. Ricard, Joshua Beaty, Logan Ruhde

International Journal of Exercise Science

International Journal of Exercise Science 11(1): 817-826, 2018.The anterior cruciate ligament (ACL) serves as a vital stabilizer for the human knee, yet it is one of the most injured ligaments in the body. Function of the knee is restored through reconstruction and physical therapy, but long term functional deficits persist in some individuals. To better understand the influence of post rehabilitation outcomes on dynamic balance performance, this study evaluated bilateral differences in strength and stability in 11 participants who have rehabilitated from an ACL reconstruction or repair. The Y-Balance Test and an isokinetic strength assessment using the Biodex ...


Increased A20-E3 Ubiquitin Ligase Interactions In Bid-Deficient Glia Attenuate Tlr3- And Tlr4-Induced Inflammation., Sinéad Kinsella, Michael Fichtner, Orla Watters, Hans-Georg Konig, Jochen HM Prehn 2018 Royal College of Surgeons in Ireland

Increased A20-E3 Ubiquitin Ligase Interactions In Bid-Deficient Glia Attenuate Tlr3- And Tlr4-Induced Inflammation., Sinéad Kinsella, Michael Fichtner, Orla Watters, Hans-Georg Konig, Jochen Hm Prehn

Physiology and Medical Physics Articles

Background: Chronic pro-inflammatory signaling propagates damage to neural tissue and affects the rate of disease progression. Increased activation of Toll-like receptors (TLRs), master regulators of the innate immune response, is implicated in the etiology of several neuropathologies including amyotrophic lateral sclerosis, Alzheimer’s disease, and Parkinson’s disease. Previously, we identified that the Bcl-2 family protein BH3-interacting domain death agonist (Bid) potentiates the TLR4-NF-κB pro-inflammatory response in glia, and specifically characterized an interaction between Bid and TNF receptor associated factor 6 (TRAF6) in microglia in response to TLR4 activation.

Methods: We assessed the activation of mitogen-activated protein kinase (MAPK) and ...


Diet Induced Obesity Alters Muscle Spindle Afferent Function In Adult Mice, Lubayna Elahi, Krystle Shamai, Adam Abtahie, Adam Cai, Shreejit Padmanabhan, Martina Bremer, Katherine A. Wilkinson 2018 San Jose State University

Diet Induced Obesity Alters Muscle Spindle Afferent Function In Adult Mice, Lubayna Elahi, Krystle Shamai, Adam Abtahie, Adam Cai, Shreejit Padmanabhan, Martina Bremer, Katherine A. Wilkinson

Faculty Publications

Populations with obesity are more likely to fall and exhibit balance instability. The reason for this is likely multifactorial, but there is some evidence that sensory function is impaired during obesity. We tested the hypothesis that muscle proprioceptor function is compromised in a mouse model of diet induced obesity. An in vitro muscle-nerve preparation was used to record muscle spindle afferent responses to physiological stretch and sinusoidal vibration. We compared the responses of C57/Bl6 male and female mice on a control diet (10% kcal fat) with those eating a high fat diet (HFD; 60% kcal fat) for 10 weeks ...


Diet Induced Obesity Alters Muscle Spindle Afferent Function In Adult Mice, Lubayna S. Elahi, Krystle N. Shamai, Adam M. Abtahie, Adam M. Cai, Shreejit Padmanabhan, Martina Bremer, Katherine A. Wilkinson 2018 San Jose State University

Diet Induced Obesity Alters Muscle Spindle Afferent Function In Adult Mice, Lubayna S. Elahi, Krystle N. Shamai, Adam M. Abtahie, Adam M. Cai, Shreejit Padmanabhan, Martina Bremer, Katherine A. Wilkinson

Katherine A. Wilkinson

Populations with obesity are more likely to fall and exhibit balance instability. The reason for this is likely multifactorial, but there is some evidence that sensory function is impaired during obesity. We tested the hypothesis that muscle proprioceptor function is compromised in a mouse model of diet induced obesity. An in vitro muscle-nerve preparation was used to record muscle spindle afferent responses to physiological stretch and sinusoidal vibration. We compared the responses of C57/Bl6 male and female mice on a control diet (10% kcal fat) with those eating a high fat diet (HFD; 60% kcal fat) for 10 weeks ...


Success Rates Of Second Semester Anatomy Students In Online And On-Ground Classes At A Community College In East Tennessee, William Sproat 2018 East Tennessee State University

Success Rates Of Second Semester Anatomy Students In Online And On-Ground Classes At A Community College In East Tennessee, William Sproat

Electronic Theses and Dissertations

Educators expect the number of institutions offering online courses and the number of students enrolling in these courses to increase as many students, particularly nontraditional students, discover the advantages of online content delivery. Online courses require new methods of communication between students and faculty as well as discovering new ways to build relationships, earn student trust, conduct appropriate assessment, and deliver useful course content. Many institutions—public, private, and for-profit—offer a wide variety of online coursework but faculty, employers, and the public have expressed concerns about the quality of online course content. In particular, online delivery of coursework in ...


Escaping The Arrhenius Tyranny: Metabolic Compensation During Exposure To High Temperature In Daphnia, Bret L. Coggins 2018 East Tennessee State University

Escaping The Arrhenius Tyranny: Metabolic Compensation During Exposure To High Temperature In Daphnia, Bret L. Coggins

Electronic Theses and Dissertations

Poikilothermic organisms experience trade-offs by differential physiological demands generated by temperature extremes. Many such organisms exhibit acclimatory effects, adjusting their metabolism and physiology to recently experienced temperatures. One such acclimatory effect is metabolic compensation, the deceleration of biological rates below Arrhenius expectations. Daphnia magna is eurythermal, and if acclimated to mildly stressful temperatures first, survives longer in lethal temperatures. This study examined the effect of ambient temperature (5°C-37°C) and acclimation history (lifetime at 10°C or 25°C) on the oxygen consumption rates of 8 genotypes of Daphnia with high or low acute temperature tolerance. There were decelerations ...


The Effect Of Ethanol On Skeletal Muscle Endocrine Function And The Novel Myokines Myonectin And Irisin, Kendra Hagood 2018 East Tennessee State University

The Effect Of Ethanol On Skeletal Muscle Endocrine Function And The Novel Myokines Myonectin And Irisin, Kendra Hagood

Electronic Theses and Dissertations

Excessive alcohol consumption is a leading cause of death and disability globally and can lead to diseases such as alcoholic skeletal myopathy. Skeletal muscle is the largest organ in the human body and functions to regulate whole-body energy homeostasis. Additionally, skeletal muscle can function as an endocrine organ via secretion of myokines. Two myokines, myonectin and irisin, present a wide range of effects upon metabolism, inflammation, and tissue survival- signaling. We hypothesized that chronic alcohol consumption will result in reduced circulating myonectin and irisin levels. Mice were fed an ethanol-containing or control diet for 10 days or 6 weeks. Tissues ...


Pleiotropic Activity Of Systemically Delivered Angiogenin In The Sod1, Martin Crivello, Saidhbhe L. O'Riordan, Ina Woods, Sarah Cannon, Luise Halang, Karen S. Coughlan, Marion C. Hogg, Sebastian A. Lewandowski, Jochen HM Prehn 2018 Royal College of Surgeons in Ireland

Pleiotropic Activity Of Systemically Delivered Angiogenin In The Sod1, Martin Crivello, Saidhbhe L. O'Riordan, Ina Woods, Sarah Cannon, Luise Halang, Karen S. Coughlan, Marion C. Hogg, Sebastian A. Lewandowski, Jochen Hm Prehn

Physiology and Medical Physics Articles

Loss-of-function mutations in the angiogenin (ANG) gene have been identified in familial and sporadic ALS patients. Previous work from our group identified human ANG (huANG) to protect motoneuronsin vitro, and provided proof-of-concept that daily intraperitoneal (i.p.) huANG injections post-symptom onset increased lifespan and delayed disease progression in SOD1G93A mice. huANG's mechanism of action remains less well understood. Here, we implemented a preclinical in vivo design to validate our previous results, provide pharmacokinetic and protein distribution data after systemic administration, and explore potential pleiotropic activities of huANG in vivo. SOD1G93A mice (n = 45) and non-transgenic controls (n = 31 ...


Design And Development Of A Quartz Crystal Microbalance Immunosensor For Exosomes, Wesley Cox 2018 University of Tennessee, Knoxville

Design And Development Of A Quartz Crystal Microbalance Immunosensor For Exosomes, Wesley Cox

University of Tennessee Honors Thesis Projects

No abstract provided.


Effects Of A Form Of Equine-Facilitated Learning On Heart Rate Variability, Immune Function, And Self-Esteem In Older Adults, Ann L. Baldwin, Barbara K. Rector, Ann C. Alden 2018 University of Arizona

Effects Of A Form Of Equine-Facilitated Learning On Heart Rate Variability, Immune Function, And Self-Esteem In Older Adults, Ann L. Baldwin, Barbara K. Rector, Ann C. Alden

People and Animals: The International Journal of Research and Practice

Equine-facilitated learning (EFL) helps people access their immediate sensations and feelings because horses, as prey animals, are continually aware of their environment and provide instant feedback to human behaviors and emotions. We hypothesize that during EFL, older people become more aware of their bodily sensations and emotions, leading to increased heart rate variability (HRV), improved self-esteem (Rosenberg scale), and improved immune function. Twenty-four subjects (age > 55) participated in a single 15-minute EFL activity, Con Su Permiso, during which they focused on their bodily sensations and the responses of the horse as they moved toward and around the horse. Subjects served ...


Determining The Effects Of Quercetin On Cadmium Toxicity In Kidney Cells, Elizabeth Dugan 2018 Bellarmine University

Determining The Effects Of Quercetin On Cadmium Toxicity In Kidney Cells, Elizabeth Dugan

Undergraduate Theses

Cadmium is a heavy transition metal that causes kidney disease via prolonged, low-level exposure due to circulating metallothioneins. These proteins transport cadmium ions to the proximal convoluted tubule, where they induce the creation of reactive oxygen species (ROS). Oxidative damage from ROS can lead to kidney dysfunction and eventually failure. Previous studies have shown that antioxidants, including quercetin, which is found in most fruits and vegetables, can lessen cadmium-induced toxicity. In this study, human embryonic kidney cells were pretreated for one hour with varying concentrations of quercetin ranging from 10 - 100 μM. This was followed by 24-hour treatment with 30 ...


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