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Recent Articles in Physiology
A C-Terminus Mitochondrial-Localization Region And Bh3 Domain Of Puma Are Required For Apoptotic Function, Liz A. Merwin 
Western University
A C-Terminus Mitochondrial-Localization Region And Bh3 Domain Of Puma Are Required For Apoptotic Function, Liz A. Merwin
University of Western Ontario - Electronic Thesis and Dissertation Repository
Apoptosis is known to contribute to the loss of neurological function in brain injury and several neurodegenerative diseases. The Bcl-2 family of proteins consist of pro-apoptotic and anti-apoptotic members that interact physically and functionally to regulate apoptosis in a cell type and stimulus specific manner. We have previously demonstrated that the Bcl-2 family member Puma plays a key role in triggering neuronal apoptosis under diverse stress conditions. However, the mechanism by which Puma mediates apoptosis remains unclear. Here we found that Puma contains two domains required for its apoptotic function: the BH3 domain and a region in the c-terminus that ...
Endogenous Inhibitor Proteins That Connect Ser/Thr Kinases And Phosphatases In Cell Signaling., Masumi Eto, David L Brautigan 
Thomas Jefferson University
Endogenous Inhibitor Proteins That Connect Ser/Thr Kinases And Phosphatases In Cell Signaling., Masumi Eto, David L Brautigan
Department of Molecular Physiology and Biophysics Faculty Papers
Protein phosphatase activity acts as a primary determinant of the extent and duration of phosphorylation of cellular proteins in response to physiological stimuli. Ser/Thr protein phosphatase-1 (PP1) belongs to the PPP superfamily, and is associated with regulatory subunits that confer substrate specificity, allosteric regulation, and subcellular compartmentalization. In addition, all eukaryotic cells contain multiple heat-stable proteins that originally were thought to inhibit phosphatase catalytic subunits released from the regulatory subunits, as a fail-safe mechanism. However, discovery of C-kinase-activated PP1 inhibitor, Mr of 17 kDa (CPI-17) required fresh thinking about the endogenous inhibitors as specific regulators of particular phosphatase complexes ...
Nuclear Localization Of Cpi-17, A Protein Phosphatase-1 Inhibitor Protein, Affects Histone H3 Phosphorylation And Corresponds To Proliferation Of Cancer And Smooth Muscle Cells., Masumi Eto, Jason A Kirkbride, Rishika Chugh, Nana Kofi Karikari, Jee In Kim Thomas Jefferson University
Nuclear Localization Of Cpi-17, A Protein Phosphatase-1 Inhibitor Protein, Affects Histone H3 Phosphorylation And Corresponds To Proliferation Of Cancer And Smooth Muscle Cells., Masumi Eto, Jason A Kirkbride, Rishika Chugh, Nana Kofi Karikari, Jee In Kim
Department of Molecular Physiology and Biophysics Faculty Papers
CPI-17 (C-kinase-activated protein phosphatase-1 (PP1) inhibitor, 17kDa) is a cytoplasmic protein predominantly expressed in mature smooth muscle (SM) that regulates the myosin-associated PP1 holoenzyme (MLCP). Here, we show CPI-17 expression in proliferating cells, such as pancreatic cancer and hyperplastic SM cells. Immunofluorescence showed that CPI-17 was concentrated in nuclei of human pancreatic cancer (Panc1) cells. Nuclear accumulation of CPI-17 was also detected in the proliferating vascular SM cell culture and cells at neointima of rat vascular injury model. The N-terminal 21-residue tail domain of CPI-17 was necessary for the nuclear localization. Phospho-mimetic Asp-substitution of CPI-17 at Ser12 attenuated the nuclear ...
Unhealthy Behaviors And The Relationship To Body Mass Index (Bmi) In College Students, J. Popivchak, B. Larouere, Carena S. Winters 
Western Kentucky University
Unhealthy Behaviors And The Relationship To Body Mass Index (Bmi) In College Students, J. Popivchak, B. Larouere, Carena S. Winters
International Journal of Exercise Science: Conference Abstract Submissions
Please view abstract in the attached PDF file.
Comparing Physiological Responses While Walking On A Standard Motorized Treadmill And Curve Treadmill, J. Phipps, S. Miller, S. Voran, M. Lister, Harold S. Kieffer Western Kentucky University
Comparing Physiological Responses While Walking On A Standard Motorized Treadmill And Curve Treadmill, J. Phipps, S. Miller, S. Voran, M. Lister, Harold S. Kieffer
International Journal of Exercise Science: Conference Abstract Submissions
Please view abstract in the attached PDF file.
Relationships Between Peak Oxygen Uptake And Arterial Function: A Preliminary Study, M. Pearman, E. DeVallance, S. Fournier, D. Bonner, B. E. Warden, W. Gharib, D. Donley, P. Chantler Western Kentucky University
Relationships Between Peak Oxygen Uptake And Arterial Function: A Preliminary Study, M. Pearman, E. Devallance, S. Fournier, D. Bonner, B. E. Warden, W. Gharib, D. Donley, P. Chantler
International Journal of Exercise Science: Conference Abstract Submissions
Please view abstract in the attached PDF file.
Cardiovascular Responses To High Intensity Aerobic And Anaerobic Exercises, A. Parker, P. Messersmith, K. Beil, K. Mahoney, K. Jones, J. A. McKenzie, S. D. McCole Western Kentucky University
Cardiovascular Responses To High Intensity Aerobic And Anaerobic Exercises, A. Parker, P. Messersmith, K. Beil, K. Mahoney, K. Jones, J. A. Mckenzie, S. D. Mccole
International Journal of Exercise Science: Conference Abstract Submissions
Please view abstract in the attached PDF file.
The Effects Of Caffeine On Maximal Anaerobic Exercise, K. Ogden, J. Haak, Harold S. Kieffer, N. Marlowe Western Kentucky University
The Effects Of Caffeine On Maximal Anaerobic Exercise, K. Ogden, J. Haak, Harold S. Kieffer, N. Marlowe
International Journal of Exercise Science: Conference Abstract Submissions
Please view abstract in the attached PDF file.
Effects Of Creatine Monohydrate Vs. Creatine Hydrochloride On Muscle Endurance Performance, K. Naylor, C. Albright, C. Liggitt, A. Kolenc, R. Robinson, W. Braun, J. Sanders Western Kentucky University
Effects Of Creatine Monohydrate Vs. Creatine Hydrochloride On Muscle Endurance Performance, K. Naylor, C. Albright, C. Liggitt, A. Kolenc, R. Robinson, W. Braun, J. Sanders
International Journal of Exercise Science: Conference Abstract Submissions
Please view abstract in the attached PDF file.
Gender-Specific Equations For Predicting Maximal Heart Rate In Exercise Stress Testing, T. Nagle, E. Godlasky, S. Weber-Peters, R. Bradford, N. Miller, M. Lott Western Kentucky University
Gender-Specific Equations For Predicting Maximal Heart Rate In Exercise Stress Testing, T. Nagle, E. Godlasky, S. Weber-Peters, R. Bradford, N. Miller, M. Lott
International Journal of Exercise Science: Conference Abstract Submissions
Please view abstract in the attached PDF file.
The Relationship Between Body Composition And Baseball Performance In Division Ii Baseball Players, B. Muth, C. A. Witmer, S. E. Davis, J. Guers Western Kentucky University
The Relationship Between Body Composition And Baseball Performance In Division Ii Baseball Players, B. Muth, C. A. Witmer, S. E. Davis, J. Guers
International Journal of Exercise Science: Conference Abstract Submissions
Please view abstract in the attached PDF file.
Body Image And Associated Behaviors Among College-Aged Students, E. Miller, B. Larouere, Carena S. Winters Western Kentucky University
Body Image And Associated Behaviors Among College-Aged Students, E. Miller, B. Larouere, Carena S. Winters
International Journal of Exercise Science: Conference Abstract Submissions
Please view abstract in the attached PDF file.
Validity Of Using Functional Threshold Power And Intermittent Power To Predict Mountain Bike Race Outcome, M. Miller, G. Moir Western Kentucky University
Validity Of Using Functional Threshold Power And Intermittent Power To Predict Mountain Bike Race Outcome, M. Miller, G. Moir
International Journal of Exercise Science: Conference Abstract Submissions
Please view abstract in the attached PDF file.
Can Standing Long Jump Distance Be Predicted From Standing Vertical Jump Distance?, L. Merk, C. Michael, Ben Meyer Western Kentucky University
Can Standing Long Jump Distance Be Predicted From Standing Vertical Jump Distance?, L. Merk, C. Michael, Ben Meyer
International Journal of Exercise Science: Conference Abstract Submissions
Please view abstract in the attached PDF file.
Effects Of A Two Week College Weight Training Course On Body Weight, Power, And Strength, J. McNamara Western Kentucky University
Effects Of A Two Week College Weight Training Course On Body Weight, Power, And Strength, J. Mcnamara
International Journal of Exercise Science: Conference Abstract Submissions
Please view abstract in the attached PDF file.
Relationship Of Mechanomyographic Amplitude To Torque Using A New Accelerometer Based Device, M. J. McMahon, S. Mookerjee Western Kentucky University
Relationship Of Mechanomyographic Amplitude To Torque Using A New Accelerometer Based Device, M. J. Mcmahon, S. Mookerjee
International Journal of Exercise Science: Conference Abstract Submissions
Please view abstract in the attached PDF file.
High Dietary Sodium Reduces Flow Mediated Dilation In Humans With Salt Sensitive & Salt Resistant Bp, E. L. Matthews, J. J. DuPont, J. L. Greaney, S. L. Lennon-Edwards, D. G. Edwards, W. B. Farquhar Western Kentucky University
High Dietary Sodium Reduces Flow Mediated Dilation In Humans With Salt Sensitive & Salt Resistant Bp, E. L. Matthews, J. J. Dupont, J. L. Greaney, S. L. Lennon-Edwards, D. G. Edwards, W. B. Farquhar
International Journal of Exercise Science: Conference Abstract Submissions
Please view abstract in the attached PDF file.
Does Eating A Meal Before Testing Alter The Percent Body Fat Measurement Determined By Bioelectrical Impedance Analysis?, B. Masteller, Curt B. Dixon, Joseph L. Andreacci Western Kentucky University
Does Eating A Meal Before Testing Alter The Percent Body Fat Measurement Determined By Bioelectrical Impedance Analysis?, B. Masteller, Curt B. Dixon, Joseph L. Andreacci
International Journal of Exercise Science: Conference Abstract Submissions
Please view abstract in the attached PDF file.
Euryhalinity In An Evolutionary Context, Eric T. Schultz, Stephen D. McCormick 
University of Connecticut
Euryhalinity In An Evolutionary Context, Eric T. Schultz, Stephen D. Mccormick
EEB Articles
This chapter focuses on the evolutionary importance and taxonomic distribution of euryhalinity. Euryhalinity refers to broad halotolerance and broad halohabitat distribution. Salinity exposure experiments have demonstrated that species vary tenfold in their range of tolerable salinity levels, primarily because of differences in upper limits. Halotolerance breadth varies with the species’ evolutionary history, as represented by its ordinal classification, and with the species’ halohabitat. Freshwater and seawater species tolerate brackish water; their empirically-determined fundamental haloniche is broader than their realized haloniche, as revealed by the halohabitats they occupy. With respect to halohabitat distribution, a minority of species (<10%) are euryhaline. Habitat-euryhalinity is prevalent among basal actinopterygian fishes, is largely absent from orders arising from intermediate nodes, and reappears in the most derived taxa. There is pronounced family-level variability in the tendency to be halohabitat-euryhaline, which may have arisen during a burst of diversification following the Cretaceous-Palaeogene extinction. Low prevalence notwithstanding, euryhaline species are potent sources of evolutionary diversity. Euryhalinity is regarded as a key innovation trait whose evolution enables exploitation of new adaptive zone, triggering cladogenesis. We review phylogenetically-informed studies that demonstrate freshwater species diversifying from euryhaline ancestors through processes such as landlocking. These studies indicate that some euryhaline taxa are particularly susceptible to changes in halohabitat and subsequent diversification, and some geographic regions have been hotspots for transitions to freshwater. Comparative studies on mechanisms among multiple taxa and at multiple levels of biological integration are needed to clarify evolutionary pathways to, and from, euryhalinity.
Voluntary Wheel Running Augments Vascular Function In Rats With Chronic Kidney Disease, C. R. Martens, J. M. Kuczmarski, S. L. Lennon-Edwards, D. G. Edwards Western Kentucky University
Voluntary Wheel Running Augments Vascular Function In Rats With Chronic Kidney Disease, C. R. Martens, J. M. Kuczmarski, S. L. Lennon-Edwards, D. G. Edwards
International Journal of Exercise Science: Conference Abstract Submissions
Please view abstract in the attached PDF file.
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