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Akt1 (E17k) Mutation Profiling In Breast Cancer: Prevalence, Concurrent Oncogenic Alterations, And Blood-Based Detection., Marion Rudolph, Tobias Anzeneder, Anke Schulz, Georg Beckmann, Annette T. Byrne, Michael Jeffers, Carol Pena, Oliver Politz, Karl Köchert, Richardus Vonk, Joachim Reischl 2016 Bayer Pharma AG

Akt1 (E17k) Mutation Profiling In Breast Cancer: Prevalence, Concurrent Oncogenic Alterations, And Blood-Based Detection., Marion Rudolph, Tobias Anzeneder, Anke Schulz, Georg Beckmann, Annette T. Byrne, Michael Jeffers, Carol Pena, Oliver Politz, Karl Köchert, Richardus Vonk, Joachim Reischl

Physiology and Medical Physics Articles

BACKGROUND: The single hotspot mutation AKT1 [G49A:E17K] has been described in several cancers, with the highest incidence observed in breast cancer. However, its precise role in disease etiology remains unknown.

METHODS: We analyzed more than 600 breast cancer tumor samples and circulating tumor DNA for AKT1 (E17K) and alterations in other cancer-associated genes using Beads, Emulsions, Amplification, and Magnetics digital polymerase chain reaction technology and targeted exome sequencing.

RESULTS: Overall AKT1 (E17K) mutation prevalence was 6.3 % and not correlated with age or menopausal stage. AKT1 (E17K) mutation frequency tended to be lower in patients with grade 3 disease ...


The Relationship Between Strength, Power, And Sprint Acceleration In Division I Men’S Soccer Players, Christopher Bellon 2016 East Tennessee State University

The Relationship Between Strength, Power, And Sprint Acceleration In Division I Men’S Soccer Players, Christopher Bellon

Electronic Theses and Dissertations

The purposes of this dissertation were three-fold. The first was to identify the approximate distances characterizing early-, mid-, and late-acceleration in a population of Division I men’s collegiate soccer players. The secondary purpose was to investigate the relationships between various strength-power variables and key sprint characteristics during early-, mid-, and late-acceleration in a population of Division I men’s soccer players. The final purpose of this dissertation was to compare the spatiotemporal characteristics of “strong” versus “weak” and “more powerful” versus “less powerful” Division I men’s soccer players during early-, mid-, and late- acceleration. The following are the ...


A Comparison Of Cervical And Trunk Musculoskeletal Characteristics Between Female And Male Army Helicopter Pilots, Takashi Nagai, Karen A. Keenan, John P. Abt, Timothy C. Sell, Brian W. Smalley, Michael D. Wirt, Scott M. Lephart 2016 University of Pittsburgh

A Comparison Of Cervical And Trunk Musculoskeletal Characteristics Between Female And Male Army Helicopter Pilots, Takashi Nagai, Karen A. Keenan, John P. Abt, Timothy C. Sell, Brian W. Smalley, Michael D. Wirt, Scott M. Lephart

International Journal of Aviation, Aeronautics, and Aerospace

Introduction: Neck pain (NP) and low back pain (LBP) are prevalent among military helicopter pilots. Although there have been few studies on sex differences in the NP/LBP prevalence in this population, females are shown to be at a greater risk of NP/LBP in civilian studies. This disparity may be due to musculoskeletal characteristics differences that predispose females for NP/LBP. The purpose of this study was to compare cervical and trunk musculoskeletal characteristics between male and female pilots. Methods: A total of 8 female pilots (Age: 27.6 ± 4.2yrs, HT: 166.1 ± 7.7cm, WT: 67.9 ...


Effects Of Acute Exercise On Postprandial Lipemia And Postprandial Glycemia, Stephen Decker 2016 Stephen F Austin State University

Effects Of Acute Exercise On Postprandial Lipemia And Postprandial Glycemia, Stephen Decker

Electronic Theses and Dissertations

Introduction: Moderate-intensity aerobic exercise has been shown to attenuate the rise in triglycerides in during the postprandial period, however the effects of acute bouts of high-intensity exercise on postprandial lipemia and glycemia have not been explored. The purpose of this study was to examine the effects of acute high-intensity interval training on postprandial lipemia and postprandial glycemia.

Methods: Ten healthy males participated in a randomized crossover design consisting of one high-intensity exercise session and one sedentary control session, followed by consumption of a mixed meal. Blood triglyceride and glucose concentrations were monitored following the consumption of the meal.

Results: High-intensity ...


The Effect Of Auditory Stimulation On Sleep Disruption In West Indian Manatee (Trichechus Manatus Latirostris), Natalija Lace 2016 University of Southern Mississippi

The Effect Of Auditory Stimulation On Sleep Disruption In West Indian Manatee (Trichechus Manatus Latirostris), Natalija Lace

Dissertations

Florida manatees inhabit waterways where motorized boats are common. Although manatee mortalities resulting from boat strikes are well documented, the effect of boat noise on some manatee behaviors, including rest, has not been investigated. This study focuses on rest behavior and used a playback experiment with four manatees at the Lowry Park Zoo in Florida. We tested their responses to playback stimuli of either boat noise, silence, or manatee calls. A playback trial was initiated when the focal animal showed behavioral characteristics of rest.

Results showed that rest was interrupted in response to the playback of boat noise for each ...


Protein Kinase Mitogen-Activated Protein Kinase Kinase Kinase Kinase 4 (Map4k4) Promotes Obesity-Induced Hyperinsulinemia, Rachel J. Roth Flach, Laura V. Danai, Marina DiStefano, Mark Kelly, Lorena Garcia Menendez, Agata Jurczyk, Rohit B. Sharma, Dae Young Jung, Jong Hun Kim, Jason K. Kim, Rita Bortell, Laura C. Alonso, Michael P. Czech 2016 University of Massachusetts Medical School

Protein Kinase Mitogen-Activated Protein Kinase Kinase Kinase Kinase 4 (Map4k4) Promotes Obesity-Induced Hyperinsulinemia, Rachel J. Roth Flach, Laura V. Danai, Marina Distefano, Mark Kelly, Lorena Garcia Menendez, Agata Jurczyk, Rohit B. Sharma, Dae Young Jung, Jong Hun Kim, Jason K. Kim, Rita Bortell, Laura C. Alonso, Michael P. Czech

Open Access Articles

Previous studies revealed a paradox whereby mitogen-activated protein kinase kinase kinase kinase 4 (Map4k4) acted as a negative regulator of insulin sensitivity in chronically obese mice, yet systemic deletion of Map4k4 did not improve glucose tolerance. Here, we report markedly reduced glucose-responsive plasma insulin and C-peptide levels in whole body Map4k4-depleted mice (M4K4 iKO) as well as an impaired first phase of insulin secretion from islets derived from M4K4 iKO mice ex vivo After long-term high fat diet (HFD), M4K4 iKO mice pancreata also displayed reduced beta cell mass, fewer proliferating beta cells and reduced islet-specific gene mRNA expression compared ...


Vitamin K2 (Menaquinone) Supplementation And Its Benefits In Cardiovascular Disease, Osteoporosis, And Cancer, Grant S. Buchanan, MD, Thomas Melvin, Brandon Merritt, Charles Bishop, MD, Franklin D. Shuler, MD, PhD 2016 Marshall University, Joan C. Edwards School of Medicine

Vitamin K2 (Menaquinone) Supplementation And Its Benefits In Cardiovascular Disease, Osteoporosis, And Cancer, Grant S. Buchanan, Md, Thomas Melvin, Brandon Merritt, Charles Bishop, Md, Franklin D. Shuler, Md, Phd

Marshall Journal of Medicine

Vitamin K is known to play an essential role in the coagulation cascade; however, a growing body of research has found that a subtype of this vitamin, vitamin K2 (menaquinone) may have a beneficial effect in osteoporosis, cardiovascular disease, and cancer. This purpose of this article is to provide a comprehensive review of recent literature regarding menaquinone and its role in human health. This review discusses the physiology of menaquinone, its clinical benefits in cardiovascular disease, osteoporosis, and cancer, and how it may interact with certain medications. The authors conclude that menaquinone supplementation has been shown to improve carboxylation ...


Temperature-Dependent Alterations Of Brown Adipose Tissue Metabolism During Hibernation In The Thirteen-Lined Ground Squirrel, Ictidomys Tridecemlineatus., Sarah V. McFarlane 2016 The University of Western Ontario

Temperature-Dependent Alterations Of Brown Adipose Tissue Metabolism During Hibernation In The Thirteen-Lined Ground Squirrel, Ictidomys Tridecemlineatus., Sarah V. Mcfarlane

Electronic Thesis and Dissertation Repository

Brown adipose tissue (BAT) is the major thermogenic tissue in small eutherian mammals. In hibernators, seasonal modifications of BAT are well documented but little is known about its functional regulation during hibernation. BAT metabolism is activated by sympathetic stimulation, so I hypothesized that further regulation at the mitochondrial level, as seen in other hibernator tissues, would be of little advantage. Contrary to my predictions, respiration rates of BAT mitochondria isolated from torpid thirteen-lined ground squirrels were suppressed by up to 62% compared with rates from individuals that aroused to interbout euthermia (IBE), when measured at 37°C. At 10°C ...


Successful Implementation Of Inquiry-Based Physiology Laboratories In Undergraduate Major And Nonmajor Courses, Giovanni Casotti, Loretta Rieser-Danner, Maureen T. Knabb 2016 West Chester University of Pennsylvania

Successful Implementation Of Inquiry-Based Physiology Laboratories In Undergraduate Major And Nonmajor Courses, Giovanni Casotti, Loretta Rieser-Danner, Maureen T. Knabb

Loretta Rieser-Danner

No abstract provided.


Dietary Weight Loss Advice In Us Health Magazines And Its Relation To Ancestral Diet, Risa J. Stein, Marium A. Choudhry, Thomas J. Murray Jr. 2016 Rockhurst University

Dietary Weight Loss Advice In Us Health Magazines And Its Relation To Ancestral Diet, Risa J. Stein, Marium A. Choudhry, Thomas J. Murray Jr.

Journal of Evolution and Health

As rates of overweight and obesity have risen in the US, the public has sought effective strategies for weight loss through dietary modification. A proliferation of processed foods and changing governmental nutrition guidelines have both impacted dietary intake patterns. While physicians are considered respectable sources of weight-loss information, increasingly the public has turned to the media, particularly magazines, for weight loss advice. This study investigated the dietary recommendations found in the five leading US health-related magazines and compared those recommendations to ancestral diets. With a couple notable exceptions, leading health magazines present consistent recommendations for dietary modifications to promote weight ...


A Bayesian Inference Comparing Collegiate Female Cyclists To Elite Female Cyclists From A Meta-Analysis, Frank B. Wyatt, Mihir Dhimar, Yesha Shah 2016 Midwestern State University

A Bayesian Inference Comparing Collegiate Female Cyclists To Elite Female Cyclists From A Meta-Analysis, Frank B. Wyatt, Mihir Dhimar, Yesha Shah

International Journal of Exercise Science

International Journal of Exercise Science 9(3): 368-375, 2016. The aim of this study was to evaluate the physiological characteristics of competitive, collegiate female cyclists (CFC) to data of elite female cyclists (EFC) obtained from a meta-analytic review. Eleven (n=11) CFC volunteered as subjects. Subjects signed a university approved informed consent. Means and standard deviation (+ SD) were obtained from the following measurements: age (y), 22.5± 5.1; height (cm) 167.22 ± 6.2; body mass (kg) 63.78 ± 9.71; body fat (%) 22.9 ± 3.6. Subjects performed a maximal cycling ergometer test to volitional fatigue. Maximal oxygen ...


Effects Of Static Stretching On Squat Performance In Division I Female Athletes, Clare F. Heisey, J. Derek Kingsley 2016 Kent State Univeristy-Kent Campus

Effects Of Static Stretching On Squat Performance In Division I Female Athletes, Clare F. Heisey, J. Derek Kingsley

International Journal of Exercise Science

International Journal of Exercise Science 9(3): 359-367, 2016. Static stretching was once recognized as a method of preparation for physical activity that would inhibit performance and increase risk of injury. However, a growing body of research suggests that static stretching may not have an inhibitory effect. Regardless, the data have not examined gender differences or the fatigue index (FI) and flexibility effects of static stretching on the back squat over multiple sets. Therefore, the purpose of this study was to examine the relationship between a static-stretch condition (SC) and control condition (CC) on flexibility and the FI of Division ...


Individual Differences In The Programming Of Rapid Bimanual Movements: Are Two Modes Better Than One?, Ashley N. Vander Does, David E. Sherwood 2016 University of Colorado, Boulder

Individual Differences In The Programming Of Rapid Bimanual Movements: Are Two Modes Better Than One?, Ashley N. Vander Does, David E. Sherwood

International Journal of Exercise Science

International Journal of Exercise Science 9(3): 347-358, 2016. One of the challenges in performing simultaneous bimanual movements is to prevent interference from one limb to the other, thereby maintaining spatial accuracy in both limbs. Prior research has shown that when a longer distance movement is performed with a shorter movement, the shorter movement overshoots its target and the longer movement undershoots its target relative to control conditions where two shorter or two longer movements are made. The current experiment investigated the motor control strategies used by participants when performing simultaneous aiming movements combining both different and same distances. Participants ...


Exercise-Induced Glycogen Reduction Increases Muscle Activity, Matthew S. Tenan, J. Troy Blackburn, Robert G. McMurray 2016 US Army Research Laboratory

Exercise-Induced Glycogen Reduction Increases Muscle Activity, Matthew S. Tenan, J. Troy Blackburn, Robert G. Mcmurray

International Journal of Exercise Science

International Journal of Exercise Science 9(3): 336-346, 2016. Intramuscular glycogen stores are an important energy source during extended bouts of strenuous exercise. A substantial reduction in glycogen could influence neural muscular drive and result in a decreasing quality of exercise performance and potentially increased injury rates. The aim of this study was to examine the effect of glycogen reduction on motor drive as determined by the surface electromyogram (EMG) amplitude and median frequency during a cycling graded exercise test. Eight trained cyclists performed a discontinuous cycling graded exercise test to exhaustion under both normal and glycogen reduced conditions. EMG ...


Power Training And Functional Performance In Middle Aged Women: A Pilot Study, Mitchel A. Magrini, J. Jay Dawes, Craig Elder, Mary Ann Kluge 2016 University of Colorado at Colorado Springs

Power Training And Functional Performance In Middle Aged Women: A Pilot Study, Mitchel A. Magrini, J. Jay Dawes, Craig Elder, Mary Ann Kluge

International Journal of Exercise Science

International Journal of Exercise Science 9(3): 327-335, 2016. Muscular power is a key component of functional performance (FP) and fall risk reduction. The present study investigated the effect that power training with medicine balls had on body composition and FP in middle-age females. 10 women were divided into a control group (n=4, age=59.8+3.6) and an intervention group (n=6, age=59.5+3.6) in this 6-week study. The intervention group completed a medicine ball training program two times a week. Body composition and FP tests were administered prepost. Data was analyzed using a ...


Do Girls With Excess Adiposity Perform Poorer Motor Skills Than Their Leaner Peers?, Daniel V. Chagas, Joyce F. Carvalho, Luiz A. Batista 2016 State University of Rio de Janeiro

Do Girls With Excess Adiposity Perform Poorer Motor Skills Than Their Leaner Peers?, Daniel V. Chagas, Joyce F. Carvalho, Luiz A. Batista

International Journal of Exercise Science

International Journal of Exercise Science 9(3): 318-326, 2016. The main aim of this study was to analyze the joint association of body fat percentage and physical activity levels on motor coordination scores in girls with different adiposity status. Sixty-eight school-aged children between 12 and 14 years participated in the study. Skinfold thickness was measured and the Körperkoordinationstest für Kinder test was administered. Participants completed a selfreporting questionnaire on physical activity. Children’s adiposity status was attributed in according to age-specific cutoff points of a Brazilian database. Analysis of Variance was used to compare motor coordination scores among groups with ...


Factors Influencing Muscular Strength And Endurance In Disadvantaged Children From Low-Income Families, Yi Fang, Ryan D. Burns, James C. Hannon, Timothy A. Brusseau 2016 University of Utah

Factors Influencing Muscular Strength And Endurance In Disadvantaged Children From Low-Income Families, Yi Fang, Ryan D. Burns, James C. Hannon, Timothy A. Brusseau

International Journal of Exercise Science

International Journal of Exercise Science 9(3): 306-317, 2016. Examining the correlates of muscular strength and endurance in children from low-income families will provide evidence for interventions to improve these parameters. The purpose of this study was to determine the predictors and trends of muscular strength and endurance in at-risk school-aged children. The sample included 1,232 children (Mean age = 8.8 ± 1.6 years; 625 girls, 607 boys; 60% Hispanic) recruited from three U.S. low-income schools. Children performed health-related fitness testing and wore pedometers for one school week. A stratified random subsample (n = 533) also wore accelerometers to ...


Perceptions Of Motivational Climate, Goal Orientations, And Light- To Vigorous-Intensity Physical Activity Engagement Of A Sample Of Finnish Grade 5 To 9 Students, Arto Gråstén, Anthony P. Watt 2016 University of Jyvaskyla

Perceptions Of Motivational Climate, Goal Orientations, And Light- To Vigorous-Intensity Physical Activity Engagement Of A Sample Of Finnish Grade 5 To 9 Students, Arto Gråstén, Anthony P. Watt

International Journal of Exercise Science

International Journal of Exercise Science 9(3): 291-305, 2016. The aim of this study was the examination of relationships between children’s perceptions of motivational climate, goal orientation, and their engagement in light- to vigorous-intensity physical activity. The sample comprised 585 school children at age of 11 to 16-year-old from three small cities located in Northeast-Finland. The cross-sectional data was collected using online questionnaires in April 2014. The findings indicated that the higher task-involving motivational climate in physical education the children reported, the higher total light- and moderate-intensity levels they accumulated. Task-involving climate also indicated higher task orientation and ego-involving ...


The Acute Effect Of Pilates Exercise On Lower Extremity Maximal Strength, Heather Monger, Blain C. Harrison 2016 Longwood University

The Acute Effect Of Pilates Exercise On Lower Extremity Maximal Strength, Heather Monger, Blain C. Harrison

International Journal of Exercise Science

International Journal of Exercise Science 9(3): 283-290, 2016. In recent years, the effects of chronic core training on athletic performance have been examined with mixed results; however, the acute effects of core training on athletic performance variables have yet to be examined. Therefore, the purpose of this study was to determine the relationship between an acute bout of core training and lower extremity maximal strength. Seventeen healthy males (weight 90.1 ± 17.2 kg; height 176.7 ± 11.2 cm; age 20.9 ± 1.3 years) performed maximal deadlift assessments following 2 testing conditions. A general cardiovascular warm-up was ...


Physiological Characteristics Of Youth Synchronized Skaters, Laura E. Fischer M.Ed., Lynn A. Darby Ph.D., Amy L. Morgan Ph.D., David A. Tobar Ph.D. 2016 Bowling Green State University

Physiological Characteristics Of Youth Synchronized Skaters, Laura E. Fischer M.Ed., Lynn A. Darby Ph.D., Amy L. Morgan Ph.D., David A. Tobar Ph.D.

International Journal of Exercise Science

International Journal of Exercise Science 9(3): 270-282, 2016. Figure skating is a lifelong sport with participation rates increasing for skaters of all ages. Development within the five disciplines of figure skating (individual skating, synchronized skating, pairs skating, ice dancing, and theater on ice) has led to increased physical demands placed on skaters’ bodies. As a result, focus on sport performance testing, training, and injury prevention specific to figure skating is increasing. The purpose of this study was to use field tests to describe the physical characteristics of synchronized skaters and to determine the relationships between these physiological characteristics and ...


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