1. Types Of Alignment: Presentations & Demos Assignment, 2016 Illinois Mathematics and Science Academy
1. Types Of Alignment: Presentations & Demos Assignment, Sarah O'Leary-Driscoll
Pairwise Alignment: DNA
Pairwise Alignment: Protein
Multiple Sequence Alignment: DNA
Multiple Sequence Alignment: Protein
Channa Striatus Tnfr-1: Molecular Cloning, Characterization And Gene Expression, 2016 SRM Institute of Science and Technology
Channa Striatus Tnfr-1: Molecular Cloning, Characterization And Gene Expression, Rajesh Palanisamy
2nd International Conference of Fish & Shellfish Immunology
No abstract provided.
A Comparative Statement On Molecular Approach Of Large Hsps From Macrobrachium Rosenbergii, Mukesh Kumar Chaurasia
2nd International Conference of Fish & Shellfish Immunology
No abstract provided.
Rasp-Qs: Efficient And Confidential Query Services In The Cloud, 2016 Wright State University - Main Campus
Rasp-Qs: Efficient And Confidential Query Services In The Cloud, Zohreh S. Alavi, Lu Zhou, James L. Powers, Keke Chen
Hosting data query services in public clouds is an attractive solution for its great scalability and significant cost savings. However, data owners also have concerns on data privacy due to the lost control of the infrastructure. This demonstration shows a prototype for efficient and confidential range/kNN query services built on top of the random space perturbation (RASP) method. The RASP approach provides a privacy guarantee practical to the setting of cloudbased computing, while enabling much faster query processing compared to the encryption-based approach. This demonstration will allow users to more intuitively understand the technical merits of the RASP approach ...
Exploration Of Chemical And Biological Management Strategies For Diaphorina Citri The Primary Vector Of Candidatus Liberibacter Asiaticus, 2016 University of Texas at Tyler
Exploration Of Chemical And Biological Management Strategies For Diaphorina Citri The Primary Vector Of Candidatus Liberibacter Asiaticus, Gretta Marie Sharp
Diaphorina citri (Hemipteran: Psyllidae), the Asian citrus psyllid, is a phloem-feeding, invasive species endemic to southern Asia that was first identified in the United States in Florida in 1998. Since introduction, D. citri has spread across the major citrus growing regions of the United States. This is of great concern to the citrus industry because D. citri is the primary vector of Candidatus Liberibacter asiaticus the causal agent of Haunglongbing (HLB). Haunglongbing is the most economically devastating disease of citrus causing an estimated 8.92 billion dollars lost in revenue and 4.62 billion dollars lost in gross domestic product ...
Initiation And Early Development Of Fiber In Wild And Cultivated Cotton, 2016 Iowa State University
Initiation And Early Development Of Fiber In Wild And Cultivated Cotton, Kara M. Butterworth, Dean C. Adams, Harry T. Horner, Jonathan F. Wendel
Cultivated cotton fiber has undergone transformation from short, coarse fibers found in progenitor wild species to economically important, long, fine fibers grown globally. Morphological transformation requires understanding of development of wild fiber and developmental differences between wild and cultivated fiber.We examined early development of fibers, including abundance and placement on seed surface, nucleus position, presence of vacuoles, and fiber size and shape. Four species were studied using microscopic, morphometric, and statistical methods: Gossypium raimondii (wild D genome), Gossypium herbaceum (cultivated A genome), Gossypium hirsutum (wild tetraploid), and Gossypium hirsutum (cultivated tetraploid). Early fiber development is highly asynchronous in G ...
Effects Of Mutating The Mrub_1345 Gene Found In Meiothermus Ruber, 2016 Augustana College, Rock Island Illinois
Effects Of Mutating The Mrub_1345 Gene Found In Meiothermus Ruber, Brandon M. Wills, Lori R. Scott
Celebration of Learning
Meiothermus ruber is a unique, red-pigmented, thermophilic bacterium that preferentially grows in high-temperature environments ranging from 35-70°C. Due to the lack of studies performed on this organism, there is quite a bit of information missing in regard to the genes found within this organism’s genome and their function. This study focuses in on the Mrub_1345 gene in M. ruber, which has been suggested to be orthologous to the proC gene found of E. coli proline biosynthesis pathway. To test if these genes are orthologs, we performed the complementation assay on wild-type proC. Next, we performed site-directed mutagenesis on ...
Homeolog Specific Expression Bias, 2016 College of William and Mary
Homeolog Specific Expression Bias, Ronald D. Smith
Biology and Medicine Through Mathematics Conference
No abstract provided.
Phylogenetic Analysis Of Human Cytomegalovirus Pus27 And Pus28: Ascertaining An Independent Or Linked Evolutionary History, 2016 University of San Francisco
Phylogenetic Analysis Of Human Cytomegalovirus Pus27 And Pus28: Ascertaining An Independent Or Linked Evolutionary History, Jessica A. Scarborough
Undergraduate Honors Theses
Human cytomegalovirus (HCMV) is a widespread pathogen that is particularly skilled at evading immune detection and defense mechanisms, largely due to extensive co-evolution with its host’s immune system. One aspect of this co-evolution involves the acquisition of four virally encoded GPCR chemokine receptor homologs, products of the US27, US28, UL33 and UL78 genes. G protein-coupled receptors (GPCR) are the largest family of cell surface proteins, found in organisms from yeast to humans. In this research, phylogenetic analysis was used to investigate the origins of the US27 and US28 genes, which are adjacent in the viral genome. The results indicate ...
Dawn Or Doom: The Risks And Rewards Of Emerging Technologies, 2016 Purdue University
Dawn Or Doom: The Risks And Rewards Of Emerging Technologies, Diana Hancock, Steve Tally, Gerry Mccartney, Michele Arthur
Purdue P-12 Networking Summit & Poster Session
Dawn or Doom is a free and open to the public conference at Purdue where we focus on benefits and risks surrounding some of the technologies that are both the most disruptive to current practices and being adopted the fastest. A collection of Purdue faculty experts and some outside speakers showcase their many perspectives related to this technology explosion, explore conditions that will foster innovation and investment into the next generation, and address the big-picture issues where both optimism and pessimism are warranted.
Genome-Wide Compensatory Changes Accompany Drug-Selected Mutations In The Plasmodium Falciparum Crt Gene, 2016 Old Dominion University
Genome-Wide Compensatory Changes Accompany Drug-Selected Mutations In The Plasmodium Falciparum Crt Gene, Hongying Jiang, Jigar J. Patel, Ming Yi, Jianbing Mu, Jinhui Ding, Robert Stephens, Roland A. Cooper, Michael T. Ferdig, Xin-Zhuan Su
Roland A. Cooper
Mutations in PfCRT (Plasmodium falciparum chloroquine-resistant transporter), particularly the substitution at amino acid position 76, confer chloroquine (CQ) resistance in P. falciparum. Point mutations in the homolog of the mammalian multidrug resistance gene (pfmdr1) can also modulate the levels of CQ response. Moreover, parasites with the same pfcrt and pfmdr1 alleles exhibit a wide range of drug sensitivity, suggesting that additional genes contribute to levels of CQ resistance (CQR). Reemergence of CQ sensitive parasites after cessation of CQ use indicates that changes in PfCRT are deleterious to the parasite. Some CQR parasites, however, persist in the field and grow well ...
Development Of Steady-State And Dynamic Flux Models For Broad-Scope Microbial Metabolism Analysis, 2016 Washington University in St. Louis
Development Of Steady-State And Dynamic Flux Models For Broad-Scope Microbial Metabolism Analysis, Lian He
Engineering and Applied Science Theses & Dissertations
Flux analysis techniques, including flux balance analysis (FBA) and 13C-metabolic flux analysis (MFA), can characterize carbon and energy flows through a cells metabolic network. By employing both 13C-labeling experiments and nonlinear programming, 13C-MFA provides a rigorous way of examining cell flux distributions in the central metabolism. FBA, on the other hand, gives a holistic review of optimal fluxomes on the genome scale. In this dissertation, flux analysis techniques were constructed to investigate the microbial metabolisms.
First, an open-source and programming-free platform of 13C-MFA (WUFlux) with a user-friendly interface in MATLAB was developed, which allowed both mass isotopomer distribution (MID) analysis ...
Design, Implementation And Evaluation Of A Medical Library Program To Support Biomedical Research In The Omics Era, Rolando Garcia-Milian, John Gallagher, Janis Glover
Design, Implementation And Evaluation Of A Medical Library Program To Support Biomedical Research In The Omics Era, Rolando Garcia-Milian
Identification Of Candidate Genes Underlying An Iron Efficiency Quantitative Trait Locus In Soybean, 2016 Iowa State University
Identification Of Candidate Genes Underlying An Iron Efficiency Quantitative Trait Locus In Soybean, Gregory A. Peiffer, Keith E. King, Andrew J. Severin, Gregory D. May, Silvia R. Cianzio, Shun Fu Lin, Nicholas C. Lauter, Randy C. Shoemaker
Prevalent on calcareous soils in the United States and abroad, iron deficiency is among the most common and severe nutritional stresses in plants. In soybean (Glycine max) commercial plantings, the identification and use of iron-efficient genotypes has proven to be the best form of managing this soil-related plant stress. Previous studies conducted in soybean identified a significant iron efficiency quantitative trait locus (QTL) explaining more than 70% of the phenotypic variation for the trait. In this research, we identified candidate genes underlying this QTL through molecular breeding, mapping, and transcriptome sequencing. Introgression mapping was performed using two related near-isogenic lines ...
Investigation Of A Mycobacteriophage Transcription Repressor, 2016 Loyola Marymount University
Investigation Of A Mycobacteriophage Transcription Repressor, Kathryn Orban
Mycobacteriophage HelDan is a lysogenic, or temperate, phage (virus) of the bacterium Mycobacterium smegmatis, which is a fast-growing, close relative of Mycobacterium tuberculosis, the causative agent of tuberculosis. The phage replication cycle is dependent on time-coordinated gene expression events. In order to study the regulation of gene expression during phage replication, HelDan protein gp73, a putative transcriptional repressor, was studied. Characterization of gp73 structure and function, such as DNA binding activity and affinity, was done using both bioinformatics and biochemical analyses. To this end, the gene encoding gp73 was cloned and the ability of the recombinant gp73 protein to bind ...
Genomic Drivers Of Cutaneous Squamous Cell Carcinoma Development, 2016 The University of Texas Graduate School of Biomedical Sciences at Houston
Genomic Drivers Of Cutaneous Squamous Cell Carcinoma Development, Vida Chitsazzadeh
UT GSBS Dissertations and Theses (Open Access)
Skin cancer is the most common malignancy in humans. Annually, in U.S. there are over 3 million cases with an estimated overall economic impact of $2 billion. Cutaneous Squamous Cell Carcinoma (cuSCC) comprises 15-20% of all skin cancers. cuSCC has the best-defined progression from a distinct precancerous lesion, the Actinic Keratosis (AK), to invasive cuSCC. Destructive therapies for AK treatment must be used repetitively, causing significant morbidity. There is a tremendous need for targeted diagnostics and therapy for AKs, representing an important opportunity for secondary skin cancer prevention. Our knowledge of the molecular and cellular events that lead to ...
Accurate Mutation Annotation And Functional Prediction Enhance The Applicability Of -Omics Data In Precision Medicine, 2016 The University of Texas Graduate School of Biomedical Sciences at Houston
Accurate Mutation Annotation And Functional Prediction Enhance The Applicability Of -Omics Data In Precision Medicine, Tenghui Chen
UT GSBS Dissertations and Theses (Open Access)
Clinical sequencing has been recognized as an effective approach for enhancing the accuracy and efficiency of cancer patient management and therefore achieve the goals of personalized therapy. However, the accuracy of large scale sequencing data in clinics has been constrained by many different aspects, such as clinical detection, annotation and interpretation of the variants that are observed in clinical sequencing data. In my Ph.D thesis work, I mainly investigated how to comprehensively and efficiently apply high dimensional -omics data to enhance the capability of precision cancer medicine. Following this motivation, my dissertation has been focused on two important topics ...
Mrub_2874 Is Homologous To B3386 And Mrub_1349 Is Homologous To B2914, But Mrub_1349 Is Not Homologous To B4090, 2016 Augustana College, Rock Island Illinois
Mrub_2874 Is Homologous To B3386 And Mrub_1349 Is Homologous To B2914, But Mrub_1349 Is Not Homologous To B4090, Samantha Murad, Dr. Lori Scott
Meiothermus ruber Genome Analysis Project
ABSTRACT. This project is part of the Meiothermus ruber genome analysis project, which uses the bioinformatics tools associated with the Guiding Education through Novel Investigation – Annotation Collaboration Toolkit (GENI-ACT) to predict gene function. We investigated the biological function of the genes Mrub_2874 and Mrub_1349. We predict that Mrub_2874 encodes the enzyme ribulose-5-phosphate 3-epimerase (DNA coordinates 2912530..2913204 on the reverse strand), which is the first step of the pentose phosphate pathway (KEGG map number 00030). It catalyzes the conversion of D-ribulose 5-phosphate to D-xylulose 5-phosphate. The E. coli K12 MG1655 ortholog is predicted to be b3386, which has the gene ...
Fragmentation Studies Of Lysine And Lysine Analog Containing Tetrapeptides, 2016 College of William and Mary
Fragmentation Studies Of Lysine And Lysine Analog Containing Tetrapeptides, Zachariah Imran Hasan
College of William & Mary Undergraduate Honors Theses
The fragmentation patterns of lysine and lysine-analog containing tetrapeptides were analyzed in this study using collision induced dissociation (CID) in an ESI-ion trap mass spectrometer. Understanding the fragmentation mechanisms of lysine-containing peptides is integral to improving bottom-up proteomics techniques and peptide sequencing and searching algorithms. Lysine and its non-protein amino acid (NPAA) analogs ornithine, DABA, and DAPA have been shown to affect fragmentation patterns based on their basicities in dipeptides and tripeptides. Studies have shown the occurrence of sequence scrambling due to macrocyclization of pentapeptides during fragmentation, which can result in inaccurate database matching. This study of the twenty tetrapeptides ...