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Characterization And Investigation Of Fungi Inhabiting The Gastrointestinal Tract Of Healthy And Diseased Humans, Mallory J. Suhr 2015 University of Nebraska-Lincoln

Characterization And Investigation Of Fungi Inhabiting The Gastrointestinal Tract Of Healthy And Diseased Humans, Mallory J. Suhr

Dissertations & Theses in Food Science and Technology

Gastrointestinal microbiome studies have failed to include fungi in total community analyses. As a result, their diversity and function in the gut is poorly understood. Recent work has begun to uncover the role intestinal fungi play in diet, immune system development, interactions with other microorganisms in the gut, and pathogenesis of diseases. Advances in sequencing technologies allow for the ability to profile the fungal gut microbiome (“mycobiome”) in healthy and diseased states. This thesis explores the mycobiome in 1) healthy humans with a vegetarian diet and 2) pediatric small bowel transplant recipients that develop fungal bloodstream infections.

The gut mycobiome ...


Investigation Of Structure-Activity Relationships Of Antimalarial Drugs Through Novel Plasmodium Falciparum Chloroquine Resistance Resistance Transporter (Pfcrt), Bianca Sanchez Mora, Samuel Lemus, Danielle Nicole Flordeliza, Jillian Nunes 2015 Dominican University of California

Investigation Of Structure-Activity Relationships Of Antimalarial Drugs Through Novel Plasmodium Falciparum Chloroquine Resistance Resistance Transporter (Pfcrt), Bianca Sanchez Mora, Samuel Lemus, Danielle Nicole Flordeliza, Jillian Nunes

Scholarly and Creative Works Conference

Mutation in the P. falciparum resistance chloroquine transporter (PfCRT) protein causes chloroquine resistance and alters susceptibility to various antimalarial drugs. Mutant PfCRT transports chloroquine out of the parasite digestive vacuole; however, the molecular details of drug-receptor interaction are poorly understood. The antiviral drug amantadine has moderate potency against P. falciparum and acts to reduce the level of chloroquine resistance determined by the pfcrt haplotype. In accordance, chloroquine-resistant parasites show enhanced sensitivity to amantadine. We used continuous, step-wise amantadine selection on three chloroquine-resistant lines of the P. falciparum 106/1 strain. Each of these lines contains a unique pfcrt allele differing ...


Analysis Of Activation Of The Nf-Κb Pathway By Shfv Infection, Ashley Aisabor 2015 Georgia State University

Analysis Of Activation Of The Nf-Κb Pathway By Shfv Infection, Ashley Aisabor

Georgia State Undergraduate Research Conference

No abstract provided.


O-Glcnacylation And Modifications To The Class Ii Transactivator, Ronald Shanderson 2015 Georgia State University

O-Glcnacylation And Modifications To The Class Ii Transactivator, Ronald Shanderson

Georgia State Undergraduate Research Conference

No abstract provided.


Preliminary Report On The Production Of A Shiga-Like Toxoid Fusion Protein As Associated With Novel Flic Vaccine, Michael Maulin 2015 Georgia State University

Preliminary Report On The Production Of A Shiga-Like Toxoid Fusion Protein As Associated With Novel Flic Vaccine, Michael Maulin

Georgia State Undergraduate Research Conference

No abstract provided.


Data From: Human And Murine Clonal Cd8+ T Cell Expansions Arise During Tuberculosis Because Of Tcr Selection, Claudio Nunes-Alves, Matthew G. Booty, Stephen Carpenter, Alissa C. Rothchild, Constance J. Martin, Danielle Desjardins, Katherine Steblenko, Henrik Kloverpris, Rajhmun Madansein, Duran Ramsuran, Alasdair Leslie, Margarida Correia-Neves, Samuel M. Behar 2015 University of Massachusetts Medical School

Data From: Human And Murine Clonal Cd8+ T Cell Expansions Arise During Tuberculosis Because Of Tcr Selection, Claudio Nunes-Alves, Matthew G. Booty, Stephen Carpenter, Alissa C. Rothchild, Constance J. Martin, Danielle Desjardins, Katherine Steblenko, Henrik Kloverpris, Rajhmun Madansein, Duran Ramsuran, Alasdair Leslie, Margarida Correia-Neves, Samuel M. Behar

MaPS Research Data

Manuscript abstract: The immune system can recognize virtually any antigen, yet T cell responses against several pathogens, including Mycobacterium tuberculosis, are restricted to a limited number of immunodominant epitopes. The host factors that affect immunodominance are incompletely understood. Whether immunodominant epitopes elicit protective CD8+ T cell responses or instead act as decoys to subvert immunity and allow pathogens to establish chronic infection is unknown. Here we show that anatomically distinct human granulomas contain clonally expanded CD8+ T cells with overlapping T cell receptor (TCR) repertoires. Similarly, the murine CD8+ T cell response against M. tuberculosis is dominated by TB10.44-11-specific ...


Taphonomic Considerations For The Analysis Of Parasites From Archaeological Contexts, Johnica J. Morrow, Dario Piombino-Mascali, Karl J. Reinhard 2015 University of Nebraska - Lincoln

Taphonomic Considerations For The Analysis Of Parasites From Archaeological Contexts, Johnica J. Morrow, Dario Piombino-Mascali, Karl J. Reinhard

Faculty Publications from the Harold W. Manter Laboratory of Parasitology

Discusses the role of taphonomy in archaeaoparasitology investigations. Enumerates various factors involved in preservation techniques. Gives cases from Lithuania, Belgium, and Italy. Concludes that considering the taphonomic factors associated with archaeological materials is a vital component in the interpretation of archaeoparasitological data.


Ectoparasitism Shortens The Breeding Season In A Colonial Bird, Charles R. Brown, Mary Bomberger Brown 2015 Department of Biological Sciences, University of Tulsa

Ectoparasitism Shortens The Breeding Season In A Colonial Bird, Charles R. Brown, Mary Bomberger Brown

Papers in Natural Resources

When blood-feeding parasites increase seasonally, their deleterious effects may prevent some host species, especially those living in large groups where parasites are numerous, from reproducing later in the summer. Yet the role of parasites in regulating the length of a host’s breeding season—and thus the host’s opportunity for multiple brooding—has not been systematically investigated. The highly colonial cliff swallow (Petrochelidon pyrrhonota), a temperate-latitude migratory songbird in the western Great Plains, USA, typically has a relatively short (eight to nine week) breeding season, with birds rarely nesting late in the summer. Colonies at which ectoparasitic swallow bugs ...


The Leishmania Years At Unl (Or, My Life As A Cell Biologist, 1966-1981), John J. Janovy Jr. 2015 University of Nebraska-Lincoln

The Leishmania Years At Unl (Or, My Life As A Cell Biologist, 1966-1981), John J. Janovy Jr.

Faculty Publications from the Harold W. Manter Laboratory of Parasitology

Slides for a talk during which Professor Janovy discussed the methods he used in researching Leishmania during the years 1966-1981. Includes lists of references.


Prehistoric Earth Oven Facilities And The Pathoecology Of Chagas Disease In The Lower Pecos Canyonlands, Karl Reinhard, Adauto Araujo 2015 University of Nebraska-Lincoln

Prehistoric Earth Oven Facilities And The Pathoecology Of Chagas Disease In The Lower Pecos Canyonlands, Karl Reinhard, Adauto Araujo

Papers in Natural Resources

Understanding the endemic region of a disease is part of developing a concept of the disease’s natural history and its threat to human health in both ancient and modern times. Chagas disease is caused by the parasite Trypanosoma cruzi and has recently been identified as an emergent disease in North America. Ancient endemicity and reemergence has been demonstrated by an examination of a mummy found on the border between Coahuila, Mexico and Texas, USA. This mummified man, who died over 1000 years ago, exhibits the gross pathology of megacolon, which is consistent with Chagas disease. We are now exploring ...


Parasitology In An Archaeological Context: Analysis Of Medieval Burials In Nivelles, Belgium, S. E. Rácz, Elisa Pucu de Araujo, E. Jensen, C. Mostek, Johnica J. Morrow, M. L. van Hove, R. Bianucci, D. Willems, F. Heller, Adauto Araujo, Karl Reinhard 2015 University of Nebraska – Lincoln

Parasitology In An Archaeological Context: Analysis Of Medieval Burials In Nivelles, Belgium, S. E. Rácz, Elisa Pucu De Araujo, E. Jensen, C. Mostek, Johnica J. Morrow, M. L. Van Hove, R. Bianucci, D. Willems, F. Heller, Adauto Araujo, Karl Reinhard

Karl Reinhard Papers/Publications

Coprolites were recovered from three burials near the Grand Place of Nivelles, Belgium. These remains yielded evidence of geohelminth parasitism. The evidence contributes to studies of differential parasite egg preservation related to the taphonomic conditions within the three burials. Using coprolite analysis techniques, parasite egg concentrations were quantified for each burial. Coprolites from the individual in Burial 122 were abnormally large and abundant, indicating an intestinal blockage. Additionally, this individual hosted an extremely high number of parasites evinced by the calculated parasite egg concentrations (Trichuris trichiura = 1,577,679 total eggs; Ascaris lumbricoides = 202,350 total eggs). Statistical analyses revealed ...


Relationship Between Heat-Labile Enterotoxin Secretion Capacity And Virulence In Wild Type Porcine-Origin Enterotoxigenic Escherichia Coli Strains, Prageeth Wijemanne, Jun Xing, Emil M. Berberov, David H. Francis, Rodney A. Moxley 2015 University of Nebraska-Lincoln

Relationship Between Heat-Labile Enterotoxin Secretion Capacity And Virulence In Wild Type Porcine-Origin Enterotoxigenic Escherichia Coli Strains, Prageeth Wijemanne, Jun Xing, Emil M. Berberov, David H. Francis, Rodney A. Moxley

Papers in Veterinary and Biomedical Science

Heat-labile enterotoxin (LT) is an important virulence factor secreted by some strains of enterotoxigenic Escherichia coli (ETEC). The prototypic human-origin strain H10407 secretes LT via a type II secretion system(T2SS). We sought to determine the relationship between the capacity to secrete LT and virulence in porcine-origin wild type (WT) ETEC strains. Sixteen WT ETEC strains isolated from cases of severe diarrheal disease were analyzed by GM1ganglioside enzyme- linked immunosorbent assay tomeasure LT concentrations in culture supernatants. All strains had detectable LT in supernatants by 2 h of culture and 1 strain, which was particularly virulent in gnotobiotic piglets (3030-2 ...


Response To David S. Lindsay Regarding “Self-Archiving Of Publications From The Journal Of Parasitology”, Sue Ann Gardner 2015 University of Nebraska - Lincoln

Response To David S. Lindsay Regarding “Self-Archiving Of Publications From The Journal Of Parasitology”, Sue Ann Gardner

Faculty Publications, UNL Libraries

Response to ASP President, David S. Lindsay, regarding his editorial in volume 36, numbers 3-4, of the ASP Newsletter, titled “Self-archiving of publications from the Journal of Parasitology.” Concludes that the Society's contract with Allen Press will expire at some point and, in the interim, there is an opportunity renegotiate with them thoughtfully, or to look for a better outlet for the time-honored Journal of Parasitology. There are many publishing ventures arising from universities themselves, in libraries and academic departments, on viable and stable electronic platforms, that require very little overhead to administer. If even a fraction of the ...


Investigation Of Wnt5a And Sfrp5 Expressions In Healthy And Chronic Periodontitis Tissues, Pacharee Kulwattanaporn 2015 University of Pennsylvania

Investigation Of Wnt5a And Sfrp5 Expressions In Healthy And Chronic Periodontitis Tissues, Pacharee Kulwattanaporn

Dental Theses

Periodontitis is a biofilm-induced chronic inflammatory disease that causes gingival inflammation and attachment loss. Destruction of periodontal tissue is a consequence of host immune inflammatory responses induced by periodontal microorganisms. Wnt5a is strongly associated with inflammatory responses and shown by several studies to be involved in inflammatory diseases including periodontitis. sFRP5 is a homolog of Wnt5a receptor, frizzled protein. sFRP5 is a known inhibitor of Wnt5a signaling. To investigate the correlation of Wnt5a and sFRP5 in periodontitis and healthy tissues, experiments were set up using both clinical specimens and further investigation with stimulations of human gingival epithelial cells (HGECs). Wnt5a ...


American Society Of Parasitologists Newsletter, V. 37, No. 1, Winter 2015, Scott Lyell Gardner 2015 University of Nebraska - Lincoln

American Society Of Parasitologists Newsletter, V. 37, No. 1, Winter 2015, Scott Lyell Gardner

Newsletter of the American Society of Parasitologists

Contents

1 -- Editor's Note

2 -- Annual Meeting Data

3 -- Response to David S. Lindsay re: Self archiving of publications from the Journal of Parasitology

6 -- NCP Meeting – Nadler report

8 -- Job - Wyoming - Parasitologist

9 -- Meetings / Course Announceme

15 -- Post Doc

17 -- Announcement – Manter Laboratory


The Effects Of Digestion On Innate Immunity, Rachel L. Luoma 2015 Georgia Southern University

The Effects Of Digestion On Innate Immunity, Rachel L. Luoma

University Honors Program Theses

Following a meal, an animal can exhibit dramatic shifts in its physiology that can result in rapid growth of the gut and heart, as well as a massive (>40-fold) increase in metabolic rate associated with the energetic costs of processing the meal. However, little is known about the effects of digestion on an important physiological trait: immune function. Thus, I tested the following competing hypotheses. First, digesting animals may upregulate their immune systems due to increased microbial exposure from ingested food. This hypothesis predicts that animals will exhibit greater immune function during digestion. Second, digesting animals may downregulate their immune ...


American Society Of Parasitologists Newsletter, V. 36, Nos. 3-4, Fall-Winter 2014, Scott Lyell Gardner 2014 University of Nebraska - Lincoln

American Society Of Parasitologists Newsletter, V. 36, Nos. 3-4, Fall-Winter 2014, Scott Lyell Gardner

Newsletter of the American Society of Parasitologists

No abstract provided.


Glutaredoxin 2 (Grx2) Gene Deletion Induces Early Onset Of Age-Dependent Cataracts In Mice, Hongli Wu, Yibo Yu, Larry David, Ye-Shih Ho, Marjorie F. Lou 2014 University of North Texas Health Science Center

Glutaredoxin 2 (Grx2) Gene Deletion Induces Early Onset Of Age-Dependent Cataracts In Mice, Hongli Wu, Yibo Yu, Larry David, Ye-Shih Ho, Marjorie F. Lou

Papers in Veterinary and Biomedical Science

Glutaredoxin 2 (Grx2) is an isozyme of glutaredoxin1 (thioltransferase) present in the mitochondria and nucleus with disulfide reductase and peroxidase activities, and it controls thiol/ disulfide balance in cells. In this study, we investigated whether Grx2 gene deletion could induce faster age-related cataract formation and elucidated the biochemical changes effected by Grx2 gene deletion that may contribute to lens opacity. Slit lamp was used to examine the lenses in Grx2 knock-out (KO) mice and age-matched wild-type (WT) mice ages 1 to 16 months. In the Grx2 null mice, the lens nuclear opacity began at 5 months, 3 months sooner than ...


Managing Devil Facial Tumour Disease In Tasmanian Devils (Sarcophilus Harrisii): An Investigation Of Heat Shock Proteins As Potential Vaccine Adjuvants, Monika Payerhin 2014 SIT Study Abroad

Managing Devil Facial Tumour Disease In Tasmanian Devils (Sarcophilus Harrisii): An Investigation Of Heat Shock Proteins As Potential Vaccine Adjuvants, Monika Payerhin

Independent Study Project (ISP) Collection

The world’s largest carnivorous marsupial, the Tasmanian devil (Sarcophilus harrisii), is facing extinction from a deadly, highly communicable cancer that has already decimated over 85% of devil populations in the wild: devil facial tumour disease (DFTD). DFTD cells effectively evade recognition by the immune system, and every devil that contracts the disease dies from it. Many attempts have been made at developing a vaccine that could help save this now-threatened species. Heat shock proteins have been linked to enhanced immune recognition of pathogens, making them potential candidates for acting as adjuvants to such a vaccine against DFTD. In this ...


Coincident Pre-Diabetes Is Associated With Dysregulated Cytokine Responses In Pulmonary Tuberculosis, Nathella Pavan Kumar, Vaithilingam V. Banurekha, Dina Nair, Rathinam Sridhar, Hardy Kornfeld, Thomas B. Nutman, Subash Babu 2014 National Institutes of Health

Coincident Pre-Diabetes Is Associated With Dysregulated Cytokine Responses In Pulmonary Tuberculosis, Nathella Pavan Kumar, Vaithilingam V. Banurekha, Dina Nair, Rathinam Sridhar, Hardy Kornfeld, Thomas B. Nutman, Subash Babu

Open Access Articles

BACKGROUND: Cytokines play an important role in the pathogenesis of pulmonary tuberculosis (PTB)--Type 2 diabetes mellitus co-morbidity. However, the cytokine interactions that characterize PTB coincident with pre-diabetes (PDM) are not known.

METHODS: To identify the influence of coincident PDM on cytokine levels in PTB, we examined circulating levels of a panel of cytokines in the plasma of individuals with TB-PDM and compared them with those without PDM (TB-NDM).

RESULTS: TB-PDM is characterized by elevated circulating levels of Type 1 (IFNgamma, TNFalpha and IL-2), Type 17 (IL-17A and IL-17F) and other pro-inflammatory (IL-1beta, IFNbeta and GM-CSF) cytokines. TB-PDM is also ...


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