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Assesment Of Antibiotic Resistant Gene Expression In Clinical Isolates Of Pseudomonas Aeruginosa, Dustin Esmond 2021 University of Texas at Tyler

Assesment Of Antibiotic Resistant Gene Expression In Clinical Isolates Of Pseudomonas Aeruginosa, Dustin Esmond

Biology Theses

Increasing prevalence of nosocomial infections by antimicrobial resistant pathogens resulting in higher mortality rates and financial burden is of great concern. Pseudomonas aeruginosa represents one of six highly virulent “ESKAPE” pathogens that exhibit considerable intrinsic drug resistance as well as mechanisms for acquiring further resistance. As many of these mechanisms are regulated through gene expression, we sought to identify regulatory strategies and patterns at play in 23 clinical isolates collected from Baku, Azerbaijan and Tyler, Texas, USA. Real-time quantitative polymerase chain reaction was performed on six gene targets implicated in resistance and contrasted with antibiotic phenotypes. We found AmpC cephalosporinase ...


A Comparison Of The Evolution, Structure, And Function Of Sars-Cov And Sars-Cov-2 Spike Proteins, Tai Michaels 2021 Yale University

A Comparison Of The Evolution, Structure, And Function Of Sars-Cov And Sars-Cov-2 Spike Proteins, Tai Michaels

The Yale Undergraduate Research Journal

As the COVID-19 pandemic has developed into the largest pandemic of the twenty-first century, it has become apparent that this disease, caused by the SARS-CoV-2 virus, is unlike anything the modern world has faced before. Not only has the disease infected more than 16 million people worldwide, but its rapid spread has drawn global attention to the gaps in our understanding of its pathogenesis and the development of vaccines and treatments. One of the most important topics of research in the disease is the viral spike (S) protein which facilitates binding and entering host cells and plays a key role ...


Covid-19 Mrna Vaccines: How They Work And Why They Are Safe, Angela Messmer-Blust 2021 University of Massachusetts Medical School

Covid-19 Mrna Vaccines: How They Work And Why They Are Safe, Angela Messmer-Blust

RTI Children's Resources

Get the facts of the COVID-19 mRNA vaccines. This infographic explains how the mRNA vaccines prevent severe disease from SARS-CoV-2, the virus causing COVID-19. These vaccines have been thoroughly tested and found to be safe and effective and continue to undergo continuous and intense safety monitoring. This infographic dispels some of the common myths associated with the vaccine.


Inflammation-Type Dysbiosis Of The Oral Microbiome Associates With The Duration Of Covid-19 Symptoms And Long-Covid, John P. Haran, Evan Bradley, Abigail Zeamer, Lindsey Cincotta, Marie-Claire Salive, Protiva Dutta, Shafik Mutaawe, Otuwe Anya, Mario Meza-Segura, Ann M. Moormann, Doyle V. Ward, Beth A. McCormick, Vanni Bucci 2021 University of Massachusetts Medical School

Inflammation-Type Dysbiosis Of The Oral Microbiome Associates With The Duration Of Covid-19 Symptoms And Long-Covid, John P. Haran, Evan Bradley, Abigail Zeamer, Lindsey Cincotta, Marie-Claire Salive, Protiva Dutta, Shafik Mutaawe, Otuwe Anya, Mario Meza-Segura, Ann M. Moormann, Doyle V. Ward, Beth A. Mccormick, Vanni Bucci

COVID-19 Publications by UMMS Authors

The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) caused the pandemic Coronavirus Disease 2019 (COVID-19) and now many face the burden of prolonged symptoms-long-lasting COVID-19 symptoms or "long-COVID". Long-COVID is thought to be linked to immune dysregulation due to harmful inflammation, with the exact causes being unknown. Given the role of the microbiome in mediating inflammation, we aimed to examine the relationship between the oral microbiome and the duration of long-COVID symptoms. Tongue swabs were collected from patients presenting with symptoms concerning for COVID-19. Confirmed infections were followed until resolution of all symptoms. Bacterial composition was determined by metagenomic sequencing ...


Characterization Of Metabolic Gene Expression In The Raw 264.7 Monocyte Cell Line, Lauren Macaisa 2021 University of North Florida

Characterization Of Metabolic Gene Expression In The Raw 264.7 Monocyte Cell Line, Lauren Macaisa

PANDION: The Osprey Journal of Research and Ideas

Immune cells undergo changes in gene expression and metabolism when activated by a foreign molecule. Although the changes are short-lived in response to an acute infection, they persist in disorders with underlying chronic inflammation. To understand how changes in gene expression relate to changes in metabolism, the expression of metabolic transporter proteins, was analyzed in response to chronic inflammation in a mouse monocyte cell line. Specifically, Glucose Transporter-1 (GLUT1), Monocarboxylate Transporter-1 (MCT1), Monocarboxylate Transporter-4 (MCT4), and Glutamate Aspartate Transporter (GLAST) were analyzed, and it was hypothesized that all the transporters would increase in expression in response to a prolonged inflammatory ...


Humoral And Cell-Mediated Immune Response In Colostrum From Women Diagnosed Positive For Sars-Cov-2, Vignesh Narayanaswamy, Brian Pentecost, Dominique Alfandari, Emily Chin, Kathleen Minor, Alyssa Kastrinakis, Tanya Lieberman, Kathleen F. Arcaro, Heidi Leftwich 2021 University of Massachusetts Amherst

Humoral And Cell-Mediated Immune Response In Colostrum From Women Diagnosed Positive For Sars-Cov-2, Vignesh Narayanaswamy, Brian Pentecost, Dominique Alfandari, Emily Chin, Kathleen Minor, Alyssa Kastrinakis, Tanya Lieberman, Kathleen F. Arcaro, Heidi Leftwich

COVID-19 Publications by UMMS Authors

Objective: To evaluate the immune response to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in colostrum from women who tested positive for the virus.

Methods: Between March and September 2020 we obtained bilateral colostrum samples collected on spot cards within 48 hours of delivery from 15 new mothers who had previously tested positive for SARS-CoV-2. Four of 15 women provided liquid colostrum, which was used for validating results obtained from spot cards. Archived bilateral colostrum samples collected from 8 women during 2011-2013 were used as pre-coronavirus disease 2019 (COVID-19) controls. All samples were tested for reactivity to the receptor binding ...


Affinity Maturation Of Sars-Cov-2 Neutralizing Antibodies Confers Potency, Breadth, And Resilience To Viral Escape Mutations, Frauke Muecksch, Shurong Hou, Celia A. Schiffer, Michel C. Nussenzweig, Pamela J. Bjorkman, Theodora Hatziioannou, Paul D. Bieniasz 2021 Rockefeller University

Affinity Maturation Of Sars-Cov-2 Neutralizing Antibodies Confers Potency, Breadth, And Resilience To Viral Escape Mutations, Frauke Muecksch, Shurong Hou, Celia A. Schiffer, Michel C. Nussenzweig, Pamela J. Bjorkman, Theodora Hatziioannou, Paul D. Bieniasz

COVID-19 Publications by UMMS Authors

Antibodies elicited by infection accumulate somatic mutations in germinal centers that can increase affinity for cognate antigens. We analyzed 6 independent groups of clonally related severe acute respiratory syndrome-coronavirus-2 (SARS-CoV-2) Spike receptor-binding domain (RBD)-specific antibodies from 5 individuals shortly after infection and later in convalescence to determine the impact of maturation over months. In addition to increased affinity and neutralization potency, antibody evolution changed the mutational pathways for the acquisition of viral resistance and restricted neutralization escape options. For some antibodies, maturation imposed a requirement for multiple substitutions to enable escape. For certain antibodies, affinity maturation enabled the neutralization ...


Roles Of A Bradykinin Storm And A Cytokine Storm In Covid-19 Cases, Nouha H. Odeh 2021 Wayne State University

Roles Of A Bradykinin Storm And A Cytokine Storm In Covid-19 Cases, Nouha H. Odeh

Honors College Theses

In the light of recent events, it is imperative to understand the key inflammatory response elements that appear to be the source of more severe ailments resulting from a SARS-CoV-2 viral infection known as Covid-19 The more severe cases of Covid-19 are characterized by a severe inflammatory response resulting in tissue damage. My research proposal aims to investigate the two possible culprits of this response: a bradykinin (BK) storm and an interleukin-6 (IL-6) mediated cytokine storm. In both systems respectively, the excess release of these signals subsequently signals the production of even more of the same response element, resulting in ...


Rsv-Induced Guillain–Barré Syndrome, Priyanga Jayakumar, Christe Shen, Dylan Goldsmith, Steven Lippmann 2021 University of Louisville

Rsv-Induced Guillain–Barré Syndrome, Priyanga Jayakumar, Christe Shen, Dylan Goldsmith, Steven Lippmann

The University of Louisville Journal of Respiratory Infections

A patient with respiratory syncytial virus-induced Guillain–Barré Syndrome and acute disseminated encephalomyelitis is presented. This virus is the most common cause of upper respiratory infections, and it can become an etiology for extra-pulmonary pathology with serious complications. Such a case is rare, but the possibility of adverse comorbidities makes early diagnosis and treatment important.


Intranasal Hpv Peptide Vaccine Formulation Induces Potent Cytotoxic Cd8 T Cell Immunity For The Treatment Of Genital Hpv Tumors, Gloria Sierra 2021 The University of Texas MD Anderson Cancer Center UTHealth Graduate School of Biomedical Sciences

Intranasal Hpv Peptide Vaccine Formulation Induces Potent Cytotoxic Cd8 T Cell Immunity For The Treatment Of Genital Hpv Tumors, Gloria Sierra

The University of Texas MD Anderson Cancer Center UTHealth Graduate School of Biomedical Sciences Dissertations and Theses (Open Access)

Human Papillomavirus (HPV) induced cancers continue to affect millions of women worldwide, with the five year survival rate hovering just under 60% in some demographics. Therefore there is an unmet need to develop effective, yet, easily administered therapies to treat established HPV genital lesions. Even though immune checkpoint therapy (ICT) is a promising treatment option in some HPV+ cancers, the high cost and associated toxicities are still major concerns for their widespread application. HPV cancers are textbook candidates for therapeutic vaccination intervention because they’re driven by the expression of viral oncoproteins E6 and E7, which serve as ideal tumor ...


Parasite Infections In Poultry Environments (Case Report On Gallus Domesticus Endoparasite), Phebe Amadea Tanuwijaya, David Febraldo 2021 Faculty of Veterinary Medicine, Universitas Udayana, Bali, Indonesia

Parasite Infections In Poultry Environments (Case Report On Gallus Domesticus Endoparasite), Phebe Amadea Tanuwijaya, David Febraldo

Journal of Environmental Science and Sustainable Development

Infection of nematode and cestode worms in chickens can cause decreased egg production, weight loss, growth problems, weakness. The objective of this case study is to look at how an epidemiological approach, clinical symptoms, anatomical pathology investigation, and laboratory testing might help with disease diagnosis. The chicken was found from Banjar Tanggahan Tengah, Bangli, Bali with the type of native chicken (Gallus domesticus), at least 3 months old with the protocol number 369 / N / 20. Samples taken were brain, trachea, lungs, liver, heart, spleen, kidneys, proventriculus, intestines, and feces. Laboratory examinations carried out include histopathology, microbiology, and parasitology. The results ...


Evolution Of Protection After Maternal Immunization For Respiratory Syncytial Virus In Cotton Rats [Preprint], Jorge C.G. Blanco, Lori McGinnes Cullen, Arash Kamali, Fatoumata Y. D. Sylla, Marina S. Boukhavalova, Trudy G. Morrison 2021 Sigmovir Biosystems, Inc

Evolution Of Protection After Maternal Immunization For Respiratory Syncytial Virus In Cotton Rats [Preprint], Jorge C.G. Blanco, Lori Mcginnes Cullen, Arash Kamali, Fatoumata Y. D. Sylla, Marina S. Boukhavalova, Trudy G. Morrison

University of Massachusetts Medical School Faculty Publications

Maternal anti-respiratory syncytial virus (RSV) antibodies acquired by the fetus through the placenta protect neonates from RSV disease through the first weeks of life. In the cotton rat model of RSV infections, we previously reported that immunization of dams during pregnancy with virus-like particles assembled with mutation stabilized pre-fusion F protein as well as the wild type G protein resulted in robust protection of their offspring from RSV challenge (Blanco, et al Journal of Virology 93: e00914-19, https://doi.org/10.1128/JVI.00914-19). Here we describe the durability of those protective responses in dams, the durability of protection in ...


High-Throughput Human Primary Cell-Based Airway Model For Evaluating Influenza, Coronavirus, Or Other Respiratory Viruses In Vitro, A. L. Gard, Ping Liu, Jennifer P. Wang, Robert W. Finberg, J. T. Borenstein 2021 Draper

High-Throughput Human Primary Cell-Based Airway Model For Evaluating Influenza, Coronavirus, Or Other Respiratory Viruses In Vitro, A. L. Gard, Ping Liu, Jennifer P. Wang, Robert W. Finberg, J. T. Borenstein

COVID-19 Publications by UMMS Authors

Influenza and other respiratory viruses present a significant threat to public health, national security, and the world economy, and can lead to the emergence of global pandemics such as from COVID-19. A barrier to the development of effective therapeutics is the absence of a robust and predictive preclinical model, with most studies relying on a combination of in vitro screening with immortalized cell lines and low-throughput animal models. Here, we integrate human primary airway epithelial cells into a custom-engineered 96-device platform (PREDICT96-ALI) in which tissues are cultured in an array of microchannel-based culture chambers at an air-liquid interface, in a ...


Ifnγ Mediated Monocyte Metabolic Reprogramming, Katelyn J. McCann 2021 University of Massachusetts Medical School

Ifnγ Mediated Monocyte Metabolic Reprogramming, Katelyn J. Mccann

GSBS Dissertations and Theses

IFNγ is an essential and pleiotropic activator of monocytes, but little is known about the effects IFNγ on cellular metabolism. Therefore, we sought to characterize and elucidate the mechanisms by which IFNγ reprograms monocyte metabolism to support its immunologic activities. First, we identified a critical role for IFNγ in the induction of immunoresponsive gene 1 (IRG1) and its product, itaconate. The immunometabolite, itaconate, has been reported to have antibacterial, anti-inflammatory and antioxidant activity. Irg1-/- mice, lacking itaconate, are highly susceptible and phenotypically similar to IFNγ knock out (GKO) mice upon infection with Mycobacterium tuberculosis. Therefore, we assessed the role of ...


Binder 183, Plagiorchiidae From Fishes [Trematoda Taxon Notebooks], Harold W. Manter Laboratory of Parasitology 2021 University of Nebraska - Lincoln

Binder 183, Plagiorchiidae From Fishes [Trematoda Taxon Notebooks], Harold W. Manter Laboratory Of Parasitology

Trematoda Taxon Notebooks

Binder 183, Plagiorchiidae from Fishes [Trematoda Taxon Notebooks].

Harold W. Manter Laboratory of Parasitology, University of Nebraska State Museum, University of Nebraska-Lincoln.

Created between 1960 and 1990.


Binder 182, Plagiorchiidae Brachycoelinae Mesocoelinae [Trematoda Taxon Notebooks], Harold W. Manter Laboratory of Parasitology 2021 University of Nebraska - Lincoln

Binder 182, Plagiorchiidae Brachycoelinae Mesocoelinae [Trematoda Taxon Notebooks], Harold W. Manter Laboratory Of Parasitology

Trematoda Taxon Notebooks

Binder 182, Plagiorchiidae Brachyceolinae Mesocoelinae [Trematoda Taxon Notebooks].

Harold W. Manter Laboratory of Parasitology, University of Nebraska State Museum, University of Nebraska-Lincoln.

Created between 1960 and 1990.


Binder 181, Plagiorchiidae Haenatoleoechinae [Trematoda Taxon Notebooks], Harold W. Manter Laboratory of Parasitology 2021 University of Nebraska - Lincoln

Binder 181, Plagiorchiidae Haenatoleoechinae [Trematoda Taxon Notebooks], Harold W. Manter Laboratory Of Parasitology

Trematoda Taxon Notebooks

Binder 181, Plagiorchiidae Haenatoleoechinae [Trematoda Taxon Notebooks].

Harold W. Manter Laboratory of Parasitology, University of Nebraska State Museum, University of Nebraska-Lincoln.

Created between 1960 and 1990.


Binder 180, Plagiorchiidae T-Z [Trematoda Taxon Notebooks], Harold W. Manter Laboratory of Parasitology 2021 University of Nebraska - Lincoln

Binder 180, Plagiorchiidae T-Z [Trematoda Taxon Notebooks], Harold W. Manter Laboratory Of Parasitology

Trematoda Taxon Notebooks

Binder 180, Plagiorchiidae T-Z [Trematoda Taxon Notebooks].

Harold W. Manter Laboratory of Parasitology, University of Nebraska State Museum, University of Nebraska-Lincoln.

Created between 1960 and 1990.


Binder 179, Plagiorchiidae Q-S [Trematoda Taxon Notebooks], Harold W. Manter Laboratory of Parasitology 2021 University of Nebraska - Lincoln

Binder 179, Plagiorchiidae Q-S [Trematoda Taxon Notebooks], Harold W. Manter Laboratory Of Parasitology

Trematoda Taxon Notebooks

Binder 179, Plagiorchiidae Q-S [Trematoda Taxon Notebooks].

Harold W. Manter Laboratory of Parasitology, University of Nebraska State Museum, University of Nebraska-Lincoln.

Created between 1960 and 1990.


Binder 178, Plagiorchiidae P [Trematoda Taxon Notebooks], Harold W. Manter Laboratory of Parasitology 2021 University of Nebraska - Lincoln

Binder 178, Plagiorchiidae P [Trematoda Taxon Notebooks], Harold W. Manter Laboratory Of Parasitology

Trematoda Taxon Notebooks

Binder 178, Plagiorchiidae P [Trematoda Taxon Notebooks].

Harold W. Manter Laboratory of Parasitology, University of Nebraska State Museum, University of Nebraska-Lincoln.

Created between 1960 and 1990.


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