Open Access. Powered by Scholars. Published by Universities.®

Immunology and Infectious Disease Commons

Open Access. Powered by Scholars. Published by Universities.®

4883 Full-Text Articles 8213 Authors 815918 Downloads 138 Institutions

All Articles in Immunology and Infectious Disease

Faceted Search

4883 full-text articles. Page 1 of 125.

Modeling Vaccination Strategies To Control White-Nose Syndrome In Little Brown Bat Colonies, Eva Cornwell, David Elzinga, Shelby Stowe, Alex Capaldi 2017 St. Olaf College

Modeling Vaccination Strategies To Control White-Nose Syndrome In Little Brown Bat Colonies, Eva Cornwell, David Elzinga, Shelby Stowe, Alex Capaldi

Annual Symposium on Biomathematics and Ecology: Education and Research

No abstract provided.


Stochastic And Deterministic Multigroup Epidemiology, Jordan Hasler, Chris Chang, Ananya Yammanuru, Lewis Oh, Esther Matthew, Mounisha Kovour 2017 Illinois Mathematics and Science Academy

Stochastic And Deterministic Multigroup Epidemiology, Jordan Hasler, Chris Chang, Ananya Yammanuru, Lewis Oh, Esther Matthew, Mounisha Kovour

Annual Symposium on Biomathematics and Ecology: Education and Research

No abstract provided.


The Kinetics Of Type I Interferons During Influenza A Virus Infection, Margaret A. Myers 2017 St. Jude Children's Research Hospital

The Kinetics Of Type I Interferons During Influenza A Virus Infection, Margaret A. Myers

Annual Symposium on Biomathematics and Ecology: Education and Research

No abstract provided.


Should I Get A Flu Shot? How Well Did This Go Last Year?, Winfried Just, David Gerberry, Ying Xin 2017 Ohio University - Main Campus

Should I Get A Flu Shot? How Well Did This Go Last Year?, Winfried Just, David Gerberry, Ying Xin

Annual Symposium on Biomathematics and Ecology: Education and Research

No abstract provided.


A Model Of Dengue Transmission With Wolbachia-Free And Wolbachia-Infected Mosquitoes, Iftikhar Ahmed 2017 Illinois State University

A Model Of Dengue Transmission With Wolbachia-Free And Wolbachia-Infected Mosquitoes, Iftikhar Ahmed

Annual Symposium on Biomathematics and Ecology: Education and Research

No abstract provided.


Markov Models Reveal Host Controls Of Within-Host Disease Dynamics, Tara Stewart, Zoi Rapti, Carla E. Cáceres 2017 University of Illinois at Urbana-Champaign

Markov Models Reveal Host Controls Of Within-Host Disease Dynamics, Tara Stewart, Zoi Rapti, Carla E. Cáceres

Annual Symposium on Biomathematics and Ecology: Education and Research

No abstract provided.


The Role Of Intermittent Preventive Treatment For Malaria In Saving Lives And Promoting Drug Resistance, Carrie Manore 2017 Illinois State University

The Role Of Intermittent Preventive Treatment For Malaria In Saving Lives And Promoting Drug Resistance, Carrie Manore

Annual Symposium on Biomathematics and Ecology: Education and Research

No abstract provided.


Bottom-Up Control Of Parasites, David S. Johnson, Richard Heard 2017 Virginia Institute of Marine Science

Bottom-Up Control Of Parasites, David S. Johnson, Richard Heard

VIMS Articles

Parasitism is a fundamental ecological interaction. Yet we understand relatively little about the ecological role of parasites compared to the role of free-living organisms. Bottom-up theory predicts that resource enhancement will increase the abundance and biomass of free-living organisms. Similarly, parasite abundance and biomass should increase in an ecosystem with resource enhancement. We tested this hypothesis in a landscape-level experiment in which salt marshes (60,000 m2 each) received elevated nutrient concentrations via flooding tidal waters for 11 yr to mimic eutrophication. Nutrient enrichment elevated the densities of the talitrid amphipod, Orchestia grillus, and the density and biomass of its ...


Suppression Of Systemic Autoimmunity By The Innate Immune Adaptor Sting, Shrutie Sharma, Allison M. Campbell, Jennie Chan, Stefan A. Schattgen, Gregory M. Orlowski, Ribhu Nayar, Annie H. Huyler, Kerstin Nundel, Chandra Mohan, Leslie J. Berg, Mark J. Shlomchik, Ann Marshak-Rothstein, Katherine A. Fitzgerald 2017 University of Massachusetts Medical School

Suppression Of Systemic Autoimmunity By The Innate Immune Adaptor Sting, Shrutie Sharma, Allison M. Campbell, Jennie Chan, Stefan A. Schattgen, Gregory M. Orlowski, Ribhu Nayar, Annie H. Huyler, Kerstin Nundel, Chandra Mohan, Leslie J. Berg, Mark J. Shlomchik, Ann Marshak-Rothstein, Katherine A. Fitzgerald

Katherine A. Fitzgerald

Cytosolic DNA-sensing pathways that signal via Stimulator of interferon genes (STING) mediate immunity to pathogens and also promote autoimmune pathology in DNaseII- and DNaseIII-deficient mice. In contrast, we report here that STING potently suppresses inflammation in a model of systemic lupus erythematosus (SLE). Lymphoid hypertrophy, autoantibody production, serum cytokine levels, and other indicators of immune activation were markedly increased in STING-deficient autoimmune-prone mice compared with STING-sufficient littermates. As a result, STING-deficient autoimmune-prone mice had significantly shorter lifespans than controls. Importantly, Toll-like receptor (TLR)-dependent systemic inflammation during 2,6,10,14-tetramethylpentadecane (TMPD)-mediated peritonitis was similarly aggravated in STING-deficient mice ...


E,E-Farnesol Inhibits Swarming Motility In Burkholderia Cepacia Through Rhamnolipid Production, Stephanie E. Nicholls, Alayna N. Sanderson, Andrea P. Schwartz, Lauren E. Ward, Jessica N. Weisensee, Molly Yandrofski, Tracy L. Collins 2017 Cedarville University

E,E-Farnesol Inhibits Swarming Motility In Burkholderia Cepacia Through Rhamnolipid Production, Stephanie E. Nicholls, Alayna N. Sanderson, Andrea P. Schwartz, Lauren E. Ward, Jessica N. Weisensee, Molly Yandrofski, Tracy L. Collins

Tracy Collins, Ph.D.

Burkholderia cepacia and Candida albicans both exhibit cell-to-cell communication through the use of quorum-sensing molecules (QSM) known as autoinducers. E,E-farnesol is a QSM produced by C. albicans which regulates its conversion from yeast to mycelium. Because there is a positive correlation between the presence of B. cepacia and C. albicans in the lungs of individuals with cystic fibrosis (CF), we examined whether E,E-farnesol had an effect on swarming motility in B. cepacia. Swarming motility was inhibited when B. cepacia was exposed to 250 µM of E,E-farnesol. In addition, there was a 26.8% decrease in rhamnolipid production ...


Infectious Disease And The Diversification Of The Human Genome, Jessica F. Brinkworth 2017 University of Illinois Urbana-Champaign

Infectious Disease And The Diversification Of The Human Genome, Jessica F. Brinkworth

Human Biology Open Access Pre-Prints

The human immune system is under great pathogen-mediated selective pressure. A combination of divergent infectious disease pathogenesis across human populations, and the overrepresentation of “immune genes” in genomic regions with signatures of positive selection suggests that pathogens have significantly altered the human genome. However, important features of the human immune system can confound searches for and interpretations of signatures of pathogen-mediated evolution. Immune system redundancy, immune gene pleiotropy, host ability to acquire immunity and alter the immune repertoire of their offspring through “priming”, and host microbiome complicate evolutionary interpretations of host- pathogen interactions. The overall promiscuity and sensitivity of the ...


Microbial Invasion Vs. Tick Immune Regulation, Daniel E. Sonenshine, Kevin R. Macaluso 2017 Old Dominion University

Microbial Invasion Vs. Tick Immune Regulation, Daniel E. Sonenshine, Kevin R. Macaluso

Biological Sciences Faculty Publications

Ticks transmit a greater variety of pathogenic agents that cause disease in humans and animals than any other haematophagous arthropod, including Lyme disease, Rocky Mountain spotted fever, human granulocytic anaplasmosis, babesiosis, tick-borne encephalitis, Crimean Congo haemorhagic fever, and many others (Gulia-Nuss et al., 2016). Although diverse explanations have been proposed to explain their remarkable vectorial capacity, among the most important are their blood feeding habit, their long term off-host survival, the diverse array of bioactive molecules that disrupt the host's natural hemostatic mechanisms, facilitate blood flow, pain inhibitors, and minimize inflammation to prevent immune rejection (Hajdušek et al., 2013 ...


Cross-Species Transmission Potential Between Wild Pigs, Livestock, Poultry, Wildlife, And Humans: Implications For Disease Risk Management In North America, Ryan S. Miller, Steven Sweeney, Chris Slootmaker, Daniel A. Grear, Paul A. Di Salvo, Deborah Kiser, Stephanie A. Shwiff 2017 USDA APHIS

Cross-Species Transmission Potential Between Wild Pigs, Livestock, Poultry, Wildlife, And Humans: Implications For Disease Risk Management In North America, Ryan S. Miller, Steven Sweeney, Chris Slootmaker, Daniel A. Grear, Paul A. Di Salvo, Deborah Kiser, Stephanie A. Shwiff

Other Publications in Zoonotics and Wildlife Disease

Cross-species disease transmission between wildlife, domestic animals and humans is an increasing threat to public and veterinary health. Wild pigs are increasingly a potential veterinary and public health threat. Here we investigate 84 pathogens and the host species most at risk for transmission with wild pigs using a network approach. We assess the risk to agricultural and human health by evaluating the status of these pathogens and the co-occurrence of wild pigs, agriculture and humans. We identified 34 (87%) OIE listed swine pathogens that cause clinical disease in livestock, poultry, wildlife, and humans. On average 73% of bacterial, 39% of ...


Forgiveness: How It Manifests In Our Health, Well-Being, And Longevity, Kathi Norman 2017 University of Pennsylvania

Forgiveness: How It Manifests In Our Health, Well-Being, And Longevity, Kathi Norman

Master of Applied Positive Psychology (MAPP) Capstone Projects

Forgiveness is a character strength and process that, when practiced, is associated with improved psychological well-being, physical health outcomes, and longevity. Forgiveness can serve as a protective factor that buffers against poor health and psychological consequences. Common misconceptions about forgiveness can serve as barriers to the desire to cultivate this protective strength, as forgiveness is often conflated with permissiveness, and perceived as permission for a transgressor to engage in hurtful conduct. The benefits of forgiveness, however, are most significant for the individual who has been transgressed, rather than the transgressor. Failing to forgive, or unforgiveness, is the practice of engaging ...


Pathways Involved In Recognition And Induction Of Trained Innate Immunity By Plasmodium Falciparum, Jacob E. Schrum 2017 University of Massachusetts Medical School

Pathways Involved In Recognition And Induction Of Trained Innate Immunity By Plasmodium Falciparum, Jacob E. Schrum

GSBS Dissertations and Theses

Malarial infection in naïve individuals induces a robust innate immune response, but our understanding of the mechanisms by which the innate immune system recognizes malaria and regulates its response remain incomplete. Our group previously showed that stimulation of macrophages with Plasmodium falciparum genomic DNA (gDNA) and AT-rich oligodeoxynucleotides (ODNs) derived from this gDNA induces the production of type I interferons (IFN-I) through a STING/TBK1/IRF3-dependent pathway; however, the identity of the upstream cytosolic DNA receptor remained elusive. Here, we demonstrate that this IFN-I response is dependent on cyclic GMP-AMP synthase (cGAS). cGAS produced the cyclic dinucleotide 2’3’-cGAMP ...


Secreted Ns1 Aids In Dengue Virus Entry By Binding Heparan Sulfate, Morgan E. Schafer, Michael Dibiasio-White, Richard J. Kuhn 2017 Purdue University

Secreted Ns1 Aids In Dengue Virus Entry By Binding Heparan Sulfate, Morgan E. Schafer, Michael Dibiasio-White, Richard J. Kuhn

The Summer Undergraduate Research Fellowship (SURF) Symposium

A large portion of the world’s population lives in an area where they are at risk of contracting Dengue Virus (DENV). While infection with DENV can result in a wide range of clinical manifestations, from flu-like symptoms to hemorrhagic shock, vascular leakage, and even death, no treatments currently exist. Previous studies have shown that higher levels of viral non-structural protein 1 (NS1) in the blood of infected patients correlate with more severe disease. NS1 has been shown to play many roles in the viral lifecycle, but the mechanisms by which NS1 executes these functions are unknown. Preliminary data from ...


Computational Drug Design: A Multitargeted Approach In Bladder Cancer, Travis C. Lantz, Joydeb Majumder, Gaurav Chopra 2017 Purdue University

Computational Drug Design: A Multitargeted Approach In Bladder Cancer, Travis C. Lantz, Joydeb Majumder, Gaurav Chopra

The Summer Undergraduate Research Fellowship (SURF) Symposium

Cancer is a complex, robust disease with multiple redundant disease pathways which lead to tumor development, growth, and eventually even death. Despite known redundancies, cancer therapeutics continue to be developed against a single protein target. Initial disease regression occurs followed by relapse in a drug resistant disease state. In response, combinational drug clinical trial targeting multiple pathways began, and have failed due to increased toxicity caused by adverse drug interactions. Development of a single drug that differentially targets multiple disease pathways will result in a more potent therapeutic while inducing minimal toxicity. This was done computationally through in-lab software packages ...


A Parapoxviral Virion Protein Inhibits Nf-Κb Signaling Early In Infection, Sushil Khatiwada, Gustavo A. Delhon, Ponnuraj Nagendraprabhu, Sabal Chaulagain, Shuhong Luo, Diego G. Diel, Eduardo F. Flores, D. L. Rock 2017 University of Illinois at Urbana-Champaign

A Parapoxviral Virion Protein Inhibits Nf-Κb Signaling Early In Infection, Sushil Khatiwada, Gustavo A. Delhon, Ponnuraj Nagendraprabhu, Sabal Chaulagain, Shuhong Luo, Diego G. Diel, Eduardo F. Flores, D. L. Rock

Papers in Veterinary and Biomedical Science

Poxviruses have evolved unique proteins and mechanisms to counteract the nuclear factor κB (NF-κB) signaling pathway, which is an essential regulatory pathway of host innate immune responses. Here, we describe a NF-κB inhibitory virion protein of orf virus (ORFV), ORFV073, which functions very early in infected cells. Infection with ORFV073 gene deletion virus (OV-IA82Δ073) led to increased accumulation of NF-κB essential modulator (NEMO), marked phosphorylation of IκB kinase (IKK) subunits IKKα and IKKβ, IκBα and NF-κB subunit p65 (NF-κB-p65), and to early nuclear translocation of NF-κB-p65 in virusinfected cells (30 min post infection). Expression of ORFV073 alone was sufficient to ...


Infection With Neuroantigen-Encoding Listeria: Induction Of Cd8 T Cell Responses And Suppression Of Demyelinating Disease, Farah R. Itani 2017 University of Iowa

Infection With Neuroantigen-Encoding Listeria: Induction Of Cd8 T Cell Responses And Suppression Of Demyelinating Disease, Farah R. Itani

Theses and Dissertations

Multiple sclerosis (MS) is an autoimmune demyelinating disorder of the central nervous system (CNS) with characteristic multifocal lesions or ‘ plaques’ of demyelination mainly in the white matter of the brain ( involving cerebral cortex, cerebellar, brain stem and spinal cord). These MS plaques vary in size and shape, and are composed of infiltrates of lymphocytes and macrophages - which contain myelin debris. CD8 T cells are more prevalent in CNS lesions and display oligoclonal expansion. However, their role in disease remains unclear with studies showing both protective and pathogenic roles for myelin-specific CD8 T cells in the experimental autoimmune encephalomyelitis (EAE) model ...


T Cell Factor-1 Regulates Cd4+ And Cd8+ T Cell Responses In A Stage-Specific Manner, Jodi Ann Gullicksrud 2017 University of Iowa

T Cell Factor-1 Regulates Cd4+ And Cd8+ T Cell Responses In A Stage-Specific Manner, Jodi Ann Gullicksrud

Theses and Dissertations

CD4+ and CD8+ T cells are critical components of the adaptive arm of immune responses. During viral infection, CD8+ T cells utilize their cytotoxic function to kill infected cells and clear the infection. In addition, CD4+ T cells differentiate into either T helper 1 (Th1) or T follicular helper (Tfh) cells, which provide essential help to enhance the efficacy of other response immune cells, including macrophages, CD8+ T cells, and B cells. The transcription factor, T cell factor-1 (TCF1), and its homologue, Lymphoid enhancer-binding factor-1 (LEF1), have critical roles in the development, differentiation, and persistence of both CD4+ and CD8 ...


Digital Commons powered by bepress