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Cross-Species Transmission Potential Between Wild Pigs, Livestock, Poultry, Wildlife, And Humans: Implications For Disease Risk Management In North America, Ryan S. Miller, Steven Sweeney, Chris Slootmaker, Daniel A. Grear, Paul A. Di Salvo, Deborah Kiser, Stephanie A. Shwiff 2017 USDA APHIS

Cross-Species Transmission Potential Between Wild Pigs, Livestock, Poultry, Wildlife, And Humans: Implications For Disease Risk Management In North America, Ryan S. Miller, Steven Sweeney, Chris Slootmaker, Daniel A. Grear, Paul A. Di Salvo, Deborah Kiser, Stephanie A. Shwiff

Other Publications in Zoonotics and Wildlife Disease

Cross-species disease transmission between wildlife, domestic animals and humans is an increasing threat to public and veterinary health. Wild pigs are increasingly a potential veterinary and public health threat. Here we investigate 84 pathogens and the host species most at risk for transmission with wild pigs using a network approach. We assess the risk to agricultural and human health by evaluating the status of these pathogens and the co-occurrence of wild pigs, agriculture and humans. We identified 34 (87%) OIE listed swine pathogens that cause clinical disease in livestock, poultry, wildlife, and humans. On average 73% of bacterial, 39% of ...


Secreted Ns1 Aids In Dengue Virus Entry By Binding Heparan Sulfate, Morgan E. Schafer, Michael Dibiasio-White, Richard J. Kuhn 2017 Purdue University

Secreted Ns1 Aids In Dengue Virus Entry By Binding Heparan Sulfate, Morgan E. Schafer, Michael Dibiasio-White, Richard J. Kuhn

The Summer Undergraduate Research Fellowship (SURF) Symposium

A large portion of the world’s population lives in an area where they are at risk of contracting Dengue Virus (DENV). While infection with DENV can result in a wide range of clinical manifestations, from flu-like symptoms to hemorrhagic shock, vascular leakage, and even death, no treatments currently exist. Previous studies have shown that higher levels of viral non-structural protein 1 (NS1) in the blood of infected patients correlate with more severe disease. NS1 has been shown to play many roles in the viral lifecycle, but the mechanisms by which NS1 executes these functions are unknown. Preliminary data from ...


Computational Drug Design: A Multitargeted Approach In Bladder Cancer, Travis C. Lantz, Joydeb Majumder, Gaurav Chopra 2017 Purdue University

Computational Drug Design: A Multitargeted Approach In Bladder Cancer, Travis C. Lantz, Joydeb Majumder, Gaurav Chopra

The Summer Undergraduate Research Fellowship (SURF) Symposium

Cancer is a complex, robust disease with multiple redundant disease pathways which lead to tumor development, growth, and eventually even death. Despite known redundancies, cancer therapeutics continue to be developed against a single protein target. Initial disease regression occurs followed by relapse in a drug resistant disease state. In response, combinational drug clinical trial targeting multiple pathways began, and have failed due to increased toxicity caused by adverse drug interactions. Development of a single drug that differentially targets multiple disease pathways will result in a more potent therapeutic while inducing minimal toxicity. This was done computationally through in-lab software packages ...


Diseases Of Sheep Observed In Iowa., W. B. Niles 2017 Iowa State College

Diseases Of Sheep Observed In Iowa., W. B. Niles

Bulletin (Iowa Agricultural Experiment Station)

Owing to the increasing importance of the sheep industry and the frequent inquiries received concerning diseases of this animal, many of which are imperfectly understood by sheep raisers and veterinarians, it was deemed advisable to investigate and obtain as much information of diseases of sheep occurring in this state as could be done in a comparatively short period of time, with the facilities at our command.


Hog Cholera And Swine Plague., W. B. Niles 2017 Iowa State College

Hog Cholera And Swine Plague., W. B. Niles

Bulletin (Iowa Agricultural Experiment Station)

The subject of hog cholera is such an important one to the people of Iowa that a brief article in these pages setting forth some of the main facts that have been observed in our work here, and elsewhere by others, seems warranted. While we have nothing to offer in the way of a specific cure and cannot point out the way by which the disease can be easily eradicated, a careful study of the facts herein set forth will enable the painstaking swine owner to more successfully deal with the two prevalent epizootic diseases of swine—hog cholera and ...


Treatment Of Currants And Cherries To Prevent Spot Diseases., L. H. Pammel, G. W. Carver 2017 Iowa State College

Treatment Of Currants And Cherries To Prevent Spot Diseases., L. H. Pammel, G. W. Carver

Bulletin (Iowa Agricultural Experiment Station)

In former bulletins of the Experiment Station, this subject has been treated. The experiments reported show quite conclusively that these diseases can be prevented by treating with Bordeaux mixture. The experiments were however repeated because Mr. D. G. Fairchild* put the currant disease in the doubtful column of those to be treated.


Investigation Of Bovine Tuberculosis, With Special Reference To Its Existence In Iowa., M. Stalker, W. B. Niles 2017 Iowa State College

Investigation Of Bovine Tuberculosis, With Special Reference To Its Existence In Iowa., M. Stalker, W. B. Niles

Bulletin (Iowa Agricultural Experiment Station)

It is our intention to give in this Bulletin which is addressed especially to the farmers of the country, conclusions drawn from tests and experiments made at our station, as well as to present in a condensed form some additional and well established facts on the subject of tuberculosis.


Checklist Of Helminths Of Bats From Mexico And Central America, F. Agustín Jiménez, Juan M. Caspeta-Mandujano, Said B. Ramírez-Chávez, Silvia E. Ramírez-Díaz, Marissa G. Juárez-Urbina, Jorge L. Peralta-Rodríguez, José A. Guerrero 2017 Southern Illinois University Carbondale

Checklist Of Helminths Of Bats From Mexico And Central America, F. Agustín Jiménez, Juan M. Caspeta-Mandujano, Said B. Ramírez-Chávez, Silvia E. Ramírez-Díaz, Marissa G. Juárez-Urbina, Jorge L. Peralta-Rodríguez, José A. Guerrero

MANTER: Journal of Parasite Biodiversity

Based on original data obtained from fieldwork conducted from January 2008 to December 2015 and from previous records from published accounts, an updated checklist of helminth parasites of bats from Mexico and Central America is presented. The checklist has been organized in four ways, first as a helminth-host list in the state of Morelos, second as a helminth-host list with taxonomic and geographic distributional information, third as a bat-helminth list with references, and last, as a summary of the host-helminth association. A total of 105 records and 67 helminth taxa (26 trematodes, 4 cestodes, and 37 nematodes [33 adult and ...


Actinomycosis And The Iodide Treatment., W. B. Niles 2017 Iowa State College

Actinomycosis And The Iodide Treatment., W. B. Niles

Bulletin (Iowa Agricultural Experiment Station)

This article is not written for the purpose of stating anything new concerning this subject, but for the purpose of recording our observations and more extensively circulating among the cattle owners of the state the knowledge that a majority of cases of “lumpy jaw” can be successfully treated by giving internally for some time the drug known as Potassium Iodide.

The very frequent occurrence of this disease in the west, coupled with the fact that many animals so affected are unfit for human food and are conseqently condemned when sent to market makes this question a very important one.


Adenovirus Prime, Env Protein Boost Vaccine Protects Against Neutralization-Resistant Sivsme660 Variants In Rhesus Monkeys, Brandon F. Keele, Wenjun Li, Erica N. Borducchi, Joseph P. Nkolola, Peter Abbink, Bing Chen, Michael S. Seaman, Dan H. Barouch 2017 Frederick National Laboratory for Cancer Research

Adenovirus Prime, Env Protein Boost Vaccine Protects Against Neutralization-Resistant Sivsme660 Variants In Rhesus Monkeys, Brandon F. Keele, Wenjun Li, Erica N. Borducchi, Joseph P. Nkolola, Peter Abbink, Bing Chen, Michael S. Seaman, Dan H. Barouch

Wenjun Li

Previous studies have shown that DNA prime, Ad5 boost vaccines protect against neutralization-sensitive but not neutralization-resistant virus variants within the SIVsmE660 swarm. Here we show that Ad prime, Env protein boost vaccines protect against neutralization-resistant SIVsmE660 variants. We perform two studies in rhesus monkeys with Ad35/Ad26 vectors expressing SIVmac239 Gag/Pol/Env with or without an AS01B-adjuvanted SIVmac32H gp140 protein boost. In a repetitive, low-dose challenge study, we observe robust protection against acquisition of infection by both Ad Alone and Ad/Env vaccines. In a single, high-dose challenge study, only the Ad/Env vaccine affords significant protection against acquisition ...


Effects Of Spraying On Plants And Fruit And Notes On Insects, Herbert Osborn 2017 Iowa State College

Effects Of Spraying On Plants And Fruit And Notes On Insects, Herbert Osborn

Bulletin (Iowa Agricultural Experiment Station)

There are a few considerations regarding spraying and its effects upon plants and fruit, that it seems important to bring before the people of the state, notwithstanding their familiarity to many readers, and the fact that most of the matter to be presented has often been repeated in various publications, and much of it in one form or another in previous bulletins of this station. The fact that this bulletin may be read by several thousand people who do not have access to previous bulletins of the station is, perhaps, sufficient reason why the repetition is justified.

There is no ...


An Aphthous Affection Among Dairy Cows Of The State, M. Stalker 2017 Iowa State College

An Aphthous Affection Among Dairy Cows Of The State, M. Stalker

Bulletin (Iowa Agricultural Experiment Station)

The following is an extract made from a report sent to the Governor’s office a few days ago, concerning a disease which has recently appeared on a number of farms in the eastern and southern counties of the state.


Some Observations On Contaminated Water Supply For Live Stock., M. Stalker 2017 Iowa State College

Some Observations On Contaminated Water Supply For Live Stock., M. Stalker

Bulletin (Iowa Agricultural Experiment Station)

There is no fact better known to the sanitarian, than that one of the chief sources of danger to life and health, is the contamination of drinking water. I f a malignant form of fever makes its appearance in a family, which cannot b$ explained by the history of actual exposure to contagium, the water supply always comes in for an early and liberal share of attention. The instances are sufficiently numerous in which the investigator is enabled to trace the malady to this source, to warrant every reasonable precaution in procuring a pure water supply.


Chinch Bug Diseases, C. P. Gillette 2017 Iowa State College

Chinch Bug Diseases, C. P. Gillette

Bulletin (Iowa Agricultural Experiment Station)

It has not been known until a comparatively recent date,that chinch bugs were subject to disease. In 1867 Dr. Shimer of Mt. Carroll, Ill. , presented a paper before the Academy of Natural Science of Philadelphia, in which he gave an account of a disease which so completely destroyed the chinch bugs in the vicinity of his home that it was impossible for him to find any specimens for his collection the following year. It was not then known and, unless specimens of the diseased bugs have been preserved, it probably never can be known with certainty what that disease ...


Role Of Tim3 In Mediating T Cell Exhaustion During Chronic Mycobacterium Tuberculosis Infection, Miye K. Jacques 2017 University of Massachusetts Medical School

Role Of Tim3 In Mediating T Cell Exhaustion During Chronic Mycobacterium Tuberculosis Infection, Miye K. Jacques

GSBS Dissertations and Theses

Mycobacterium tuberculosis infection is one of the leading causes of mortality worldwide. One third of the population is estimated to be infected, however only 5-10% of those individuals can transmit the disease. While T cell immunity initially limits mycobacterium growth, it is unclear why T cell immunity fails to sterilize the infection and prevent subsequent recrudescence. One hypothesis is T cell exhaustion is mediating the failure of T cell immunity late during infection. Here we show the development of T cell exhaustion during chronic infection, and that the inhibitory receptor T cell-immunoglobulin and mucin domain containing 3 (TIM3) mediates the ...


Ectoparasitic Mites Of The Genus Gigantolaelaps (Acari: Mesostigmata: Laelapidae) Associated With Small Mammals Of The Genus Nephelomys (Rodentia: Sigmodontinae), Including Two New Species From Peru, Donald D. Gettinger, Scott Lyell Gardner 2017 University of Nebraska - Lincoln

Ectoparasitic Mites Of The Genus Gigantolaelaps (Acari: Mesostigmata: Laelapidae) Associated With Small Mammals Of The Genus Nephelomys (Rodentia: Sigmodontinae), Including Two New Species From Peru, Donald D. Gettinger, Scott Lyell Gardner

Scott Gardner Publications & Papers

An extensive survey of small mammals and ectoparasites along an altitudinal transect in the Manu Biodiversity Reserve in Peru found the sigmodontine rodent genus Nephelomys infested by mites of the genus Gigantolaelaps Fonseca, 1939. Two distinct species co-occurred exclusively in the pelage of Nephelomys keaysi, G. inca Fonseca and G. minima n. sp. Nephelomys levipes, which replaces N. keaysi at higher elevations, was infested exclusively with a single new species, G. nebulosa n. sp. In this paper, we formally describe these new mite species, and provide more information on the morphology of G. inca.


American Society Of Parasitologists Newsletter, Volume 39, Number 1, Summer 2017, Scott Lyell Gardner 2017 University of Nebraska - Lincoln

American Society Of Parasitologists Newsletter, Volume 39, Number 1, Summer 2017, Scott Lyell Gardner

Newsletter of the American Society of Parasitologists

Summer 2017 issue of the ASP newsletter.


Helminth Infection-Induced Malignancy., Paul J Brindley, Alex Loukas 2017 George Washington University

Helminth Infection-Induced Malignancy., Paul J Brindley, Alex Loukas

Microbiology, Immunology, and Tropical Medicine Faculty Publications

Infectious diseases cause more than 20% of cancers in the developing world [1]. About a dozen pathogens including Epstein-Barr virus and human T cell lymphocytotropic virus 1 are among the well-known examples. In addition, infection with several trematodes, which are eukaryotes, can cause malignancy. The International Agency for Research on Cancer categorizes infection with the fish-borne trematodes Opisthorchis viverrini and Clonorchis sinensis and the blood fluke Schistosoma haematobium as Group 1 biological carcinogens [2]. In addition to parasitism directly damaging development, health, and prosperity of infected populations, infection with these helminths leads to cholangiocarcinoma (CCA) (bile duct cancer) and squamous ...


Finding A Link Between Circadian Rhythms And The Immune System Of Captive Zebra Finches (Taeniopygia Guttata), Amber Bishop 2017 Western Kentucky University

Finding A Link Between Circadian Rhythms And The Immune System Of Captive Zebra Finches (Taeniopygia Guttata), Amber Bishop

Honors College Capstone Experience/Thesis Projects

Circadian rhythms are commonplace in organisms and are normally controlled by a master clock. More recent evidence suggests that autonomous clocks operate in various systems in the body, including the immune system. This study looks for such a connection between the circadian rhythm and the immune system. In this study, captive zebra finches (Taeniopygia guttata) were exposed to different light and dark cycles and blood samples were taken every six hours. Birds were exposed to 12 hours of light and then 12 hours of darkness (LD), 24 hours of darkness (DD), or 48 hours of DD. After collecting whole blood ...


Edaxadiene: A New Bioactive Diterpene From Mycobacterium Tuberculosis, Francis M. Mann, Meimei Xu, Xiaoming Chen, D. Bruce Fulton, David G. Russell, Reuben J. Peters 2017 Iowa State University

Edaxadiene: A New Bioactive Diterpene From Mycobacterium Tuberculosis, Francis M. Mann, Meimei Xu, Xiaoming Chen, D. Bruce Fulton, David G. Russell, Reuben J. Peters

Reuben J. Peters

Mycobacterium tuberculosis remains a widespread and devastating human pathogen. Presented here is the characterization of an atypical class I diterpene cyclase from M. tuberculosis that catalyzes an unusual cyclization reaction in converting the known M. tuberculosis metabolite halimadienyl diphosphate to a further cyclized novel diterpene, which we have termed edaxadiene, as it directly inhibits maturation of the phagosomal compartment in which the bacterium is taken up during infection.


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