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Co-Expression Of Vegf And Il-6 Family Cytokines Is Associated With Decreased Survival In Her2 Negative Breast Cancer Patients: Subtype-Specific Il-6 Family Cytokine-Mediated Vegf Secretion, Ken Tawara, Hannah Scott, Jacqueline Emathinger, Alex Ide, Ryan Fox, Daniel Greiner, Dollie LaJoie, Danielle Hedeen, Madhuri Nandakumar, Andrew J. Oler, Ryan Holzer, Cheryl Jorcyk 2019 Boise State University

Co-Expression Of Vegf And Il-6 Family Cytokines Is Associated With Decreased Survival In Her2 Negative Breast Cancer Patients: Subtype-Specific Il-6 Family Cytokine-Mediated Vegf Secretion, Ken Tawara, Hannah Scott, Jacqueline Emathinger, Alex Ide, Ryan Fox, Daniel Greiner, Dollie Lajoie, Danielle Hedeen, Madhuri Nandakumar, Andrew J. Oler, Ryan Holzer, Cheryl Jorcyk

Biology Faculty Publications and Presentations

Breast cancer cell-response to inflammatory cytokines such as interleukin-6 (IL-6) and oncostatin M (OSM) may affect the course of clinical disease in a cancer subtype-dependent manner. Furthermore, vascular endothelial growth factor A (VEGF) secretion induced by IL-6 and OSM may also be subtype-dependent. Utilizing datasets from Oncomine, we show that poor survival of invasive ductal carcinoma (IDC) breast cancer patients is correlated with both high VEGF expression and high cytokine or cytokine receptor expression in tumors. Importantly, epidermal growth factor receptor-negative (HER2-), but not HER2-positive (HER2+), patient survival is significantly lower with high tumor co-expression of VEGF and OSM, OSMRβ ...


Anolis Newsletter Vii, James T. Stroud, Anthony J. Geneva, Jonathan B. Losos 2019 Washington University in St. Louis

Anolis Newsletter Vii, James T. Stroud, Anthony J. Geneva, Jonathan B. Losos

Biology Faculty Publications & Presentations

Newsletter for the 7th Anolis Symposium, Fairchild Tropical Botanic Gardens, Miami, Florida, 17-18 March 2018.

It had been nearly a decade since the previous Anolis symposium was held in Cambridge, MA, at the Museum for Comparative Zoology, Harvard. A reunion of anole biologists en masse was long past due and it was decided that this symposium would be slightly different – we were going to hold it somewhere with anoles! And so, on the weekend of 17-18th March, 2018, nearly 70 anole biologists traveled to sunny south Florida to attend the 7th Anolis Symposium held at the beautiful Fairchild Tropical Botanic ...


Exploring The Ipf Lung Through The Lens Of Single Cell Rna Sequencing, Taylor Adams, Jonas Schupp 2019 Yale School of Medicine

Exploring The Ipf Lung Through The Lens Of Single Cell Rna Sequencing, Taylor Adams, Jonas Schupp

Yale Day of Data

This poster illustrates the differences between the IPF disease-specific variety of lung macrophages and the two varieties of macrophages known to reside in the normal human lung.


The Effect Of Nonassociative Learning On Oxidative Stress In Caenorhabditis Elegans: A Potential Application For Alzheimer’S Disease Research, Gillian Patton 2019 Spring Valley High School

The Effect Of Nonassociative Learning On Oxidative Stress In Caenorhabditis Elegans: A Potential Application For Alzheimer’S Disease Research, Gillian Patton

Journal of the South Carolina Academy of Science

Alzheimer’s disease results in learning and memory deficits due to toxic changes in the brain caused by amyloid-β plaques and oxidative stress. Oxidative stress is caused by the overproduction of free radicals, which are uncharged molecules containing an unpaired valence electron. Nonassociative learning is a type of cognitive processing that only uses one stimulus instead of two related stimuli. Cognitive processing promotes neural growth and learning, while Alzheimer’s inhibits it. The purpose of this study was to test how nonassociative learning impacts oxidative stress and thus, if it might be considered as a potential treatment option for Alzheimer ...


The Effect Of Flavonoid Galangin On The Cell Viability And Toxicity Of Mcf-7 Human Breast Cancer Cells Exposed To Polycyclic Aromatic Hydrocarbons (Pahs), Abhimanyu Sailesh 2019 Blythewood High School, Blythewood, SC

The Effect Of Flavonoid Galangin On The Cell Viability And Toxicity Of Mcf-7 Human Breast Cancer Cells Exposed To Polycyclic Aromatic Hydrocarbons (Pahs), Abhimanyu Sailesh

Journal of the South Carolina Academy of Science

Polycyclic aromatic hydrocarbons (PAHs) are chemical compounds ubiquitous in the environment; many of which are known human and animal carcinogen. The purpose of this study was to investigate MCF-7 epithelial breast cancer cells’ viability and toxicity following a short-term in vitro exposure to a cocktail of PAHs and benzo[a]pyrene (B[a]P) separately in the presence and absence of varying concentrations of flavonoid galangin. It was predicted that presence of galangin will completely or partially block the damaging effects of PAHs. It was hypothesized that exposing the cells to 7 µM cocktail of PAHs or 10 µM B ...


The Effect Of Hordeum Vulgare, Rice Hull, And Oak Leaf Litter On The Prevalence Of Microcystis, Sreya Varanasi 2019 Spring Valley High School

The Effect Of Hordeum Vulgare, Rice Hull, And Oak Leaf Litter On The Prevalence Of Microcystis, Sreya Varanasi

Journal of the South Carolina Academy of Science

Cyanobacterial harmful algal blooms are becoming more prevalent issues throughout the world, threatening ecosystems, posing risks to human health, and resulting in millions of dollars in economic damage. Conventionally, treatment approaches have been chemical or physical, but these are harmful to aquatic life or inefficient, respectively, which presents the biological approach as a favorable alternative. To assess the effects of low-effort and cost-effective treatments, Hordeum vulgare, rice hull, and oak leaf litter were individually applied to Microcystis cultures and compared to two negative controls (Microcystis alone and cotton on Microcystis) and a positive control (CuSO4). This research was aimed ...


Epha4b Expression In The Craniofacial Development Of African Cichlid Fishes, Chelse VanAtter 2019 Clemson University and South Carolina Governor’s School for Science and Mathematics

Epha4b Expression In The Craniofacial Development Of African Cichlid Fishes, Chelse Vanatter

Journal of the South Carolina Academy of Science

Epha4b gene expression may contribute to variances in facial formation including functional differences such as nose shape and clinical conditions such as cleft palate. During craniofacial development, neural crest cells migrate to the pharyngeal arches then differentiate to form bone, muscle, and cartilage cells. The Eph/ephrin signaling pathway guides the streams of migrating neural crest cells into the pharyngeal arches; epha4b, a gene encoding an Eph receptor, contributes to this signaling pathway. To determine how epha4b expression differs between species at different developmental stages, in situ hybridization, a process that stains areas of gene expression, was performed. African cichlid ...


The Effects Of Matthew’S Storm Surge On Coastal Loblolly Pine And Wax Myrtle Understory Regeneration, Brynn D. Wilkinson 2019 South Carolina Governor's School for Science and Mathematics

The Effects Of Matthew’S Storm Surge On Coastal Loblolly Pine And Wax Myrtle Understory Regeneration, Brynn D. Wilkinson

Journal of the South Carolina Academy of Science

Hurricanes have detrimental effects on the environment and the economy. Not only are these effects felt immediately after the hurricane, but they last long after the winds have died down. They can affect future plant growth and mortality. In October of 2016 South Carolina was hit by Hurricane Matthew, a category 5 hurricane. Hobcaw Barony, our study site, was in the direct path of the storm. This created an opportunity to study the immediate effects on regeneration after a hurricane. Regenerations rates were measured along and around a surge line to determine regeneration and mortality rates. This data also allowed ...


An Evaluation Of Galleria Mellonella As A Model For Aspergillus Ustus Infections, Isak Jatoi 2019 Spring Valley High School

An Evaluation Of Galleria Mellonella As A Model For Aspergillus Ustus Infections, Isak Jatoi

Journal of the South Carolina Academy of Science

Invasive aspergillosis is a serious cause of mortality and morbidity in immunocompromised hosts. In particular, the emergence of multidrug-resistant fungi, such as Aspergillus calidoustus, poses a concern for both doctors and patients. Rapid screening in vivo of novel antifungals is essential for discovering new treatments to combat invasive aspergillosis and improve prognosis of patients. As such, this study proposed the use of the greater wax moth, Galleria mellonella, as a quick way to model A. calidoustus infection. Due to the dangers of working with A. calidoustus in a high school setting, A. ustus was used in experimentation. It was hypothesized ...


The Effects Of Oxidative Stress On Inducing Senescence In Human Fibroblasts, Shivani Chowdhary 2019 South Carolina Governor's School for Science and Mathematics

The Effects Of Oxidative Stress On Inducing Senescence In Human Fibroblasts, Shivani Chowdhary

Journal of the South Carolina Academy of Science

Oxidative stress, specifically from hydrogen peroxide exposure, was performed to determine if it induced senescence in cell lines such as Hela cells and primary human fibroblasts. The purpose of this experiment was to find the optimal stage, concentration, and time of exposure to induce the greatest number of senescent cells. After dividing cultures of both the Hela and human fibroblasts cells in order to reduce confluency, the cells were placed in a six well plate and exposed to hydrogen peroxide for two hours at various concentrations. The plates were checked at twenty-four-hour intervals, and then fixed with senescence associated beta-galactosidase ...


The Effect Of Acetaminophen (Analgesic) And Diphenhydramine (Antihistamine) On Nociception Response Of Caenorhabditis Elegans, Heart Rate Of Eisenia Fetida, And Mortality Of Both E. Fetida And C. Elegans, Vamsi Gorrepati 2019 Spring Valley High School

The Effect Of Acetaminophen (Analgesic) And Diphenhydramine (Antihistamine) On Nociception Response Of Caenorhabditis Elegans, Heart Rate Of Eisenia Fetida, And Mortality Of Both E. Fetida And C. Elegans, Vamsi Gorrepati

Journal of the South Carolina Academy of Science

Pharmaceutical pollution continues to increase each year but its adverse effects on the environment are still largely unknown. Pharmaceuticals can enter the terrestrial ecosystem when animal manure and sewage sludge are applied to land as a fertilizer or when irrigated with contaminated water. To understand the extent to which common drugs impact the ecosystem, two commonly polluting pharmaceuticals, acetaminophen and diphenhydramine, which have been found in many cities such as Chicago, Dallas, and most notably The Great Lakes, were studied. Various concentrations were tested on E. fetida and C. elegans. Indicators such as heart rate were observed for E. fetida ...


Sex-Related Differences In Immune Response And Symptomatic Manifestations To Infection With Leishmania Species, Ryan D. Lockard, Mary E. Wilson, Nilda E. Rodriguez 2019 University of Northern Iowa

Sex-Related Differences In Immune Response And Symptomatic Manifestations To Infection With Leishmania Species, Ryan D. Lockard, Mary E. Wilson, Nilda E. Rodriguez

Biology Faculty Publications

Worldwide, an estimated 12 million people are infected with Leishmania spp. and an additional 350 million are at risk of infection. Leishmania are intracellular parasites that cause disease by suppressing macrophage microbicidal responses. Infection can remain asymptomatic or lead to a spectrum of diseases including cutaneous, mucocutaneous, and visceral leishmaniasis. Ultimately, the combination of both pathogen and host factors determines the outcome of infection. Leishmaniasis, as well as numerous other infectious diseases, exhibits sex-related differences that cannot be explained solely in terms of environmental exposure or healthcare access. Furthermore, transcriptomic evidence is revealing that biological sex is a variable impacting ...


Targeted Resequencing Of Crispr Cas9 Mediated Icer Knockout In Sk-Mel-24 Cells, Justin Wheelan 2019 Montclair State University

Targeted Resequencing Of Crispr Cas9 Mediated Icer Knockout In Sk-Mel-24 Cells, Justin Wheelan

Theses, Dissertations and Culminating Projects

Inducible cAMP Early Repressor (ICER) is a small transcription factor that originates from an intronic promoter within the cAMP Response Element Modulator (CREM) gene (Molina et al., 1993). ICER acts as a putative tumor suppressor by mediating cAMP antiproliferative activity by competitively binding to cAMP Response Elements (CRE’s) and repressing transcription of genes involved in cell division (Mémin et al., 2002). ICER has been shown to be effectively absent in cancer and suspected to be targeted for proteasomal degradation via ubiquitination (Healey et al., 2013). ICER is most likely regulated via post-translational modifications as a result of mutations on ...


Table Of Contents, 2018 University of South Carolina

Table Of Contents

Journal of the South Carolina Academy of Science

No abstract provided.


Ne Stem 4u Afterschool Intervention Leads To Gains In Stem Content Knowledge For Middle School Youth, Christine E. Cutucache, Taylor Boham, Jamie Luhr, Amie Sommers, Nikolaus Stevenson, Erkko Sointu, Kati Mäkitalo‐Siegl, Sirpa Kärkkäinen, Teemu Valtonen, Neal Grandgenett, William Tapprich 2018 University of Nebraska at Omaha

Ne Stem 4u Afterschool Intervention Leads To Gains In Stem Content Knowledge For Middle School Youth, Christine E. Cutucache, Taylor Boham, Jamie Luhr, Amie Sommers, Nikolaus Stevenson, Erkko Sointu, Kati Mäkitalo‐Siegl, Sirpa Kärkkäinen, Teemu Valtonen, Neal Grandgenett, William Tapprich

Biology Faculty Publications

Afterschool interventions in STEM are linked to learning gains during the school day. These opportunities engage and excite students about STEM concepts since they observe a more hands-on, project-oriented approach. Often these opportunities for afterschool interventions are infrequent in nature and leave gaps for students in their maturation and understanding. Herein we describe the first report of an afterschool intervention, named NE STEM 4U, targeting socioeconomically disadvantaged middle school youth via a twice weekly, year-long intervention, studied across two years. We assessed the impact of this program on i.) short-term, individual student gains in STEM content knowledge and ii.) delivery ...


Living Shoreline Stabilization To Increase Resiliency At De Soto National Memorial, Linda Walters, Melinda Donnelly, Christian Pilato, Suzanne Connor 2018 University of Central Florida

Living Shoreline Stabilization To Increase Resiliency At De Soto National Memorial, Linda Walters, Melinda Donnelly, Christian Pilato, Suzanne Connor

CEELAB Research Data

De Soto National Memorial (Bradenton, FL) is an important location where both Native Americans and De Soto's army of soldiers once lived. We have been working closely with the National Park Service and the University of Central Florida to understand how to best stabilize this shoreline using living shoreline techniques combined with long-term natural recruitment. Stabilizing De Soto's shoreline is essential to decrease erosion and shoreline loss to protect the Park's cultural and natural resources, especially the numerous historically significant shell middens. Through pre-restoration monitoring, we determined that high-energy boat wakes were limiting natural mangrove recruitment. Lack ...


The Trim-Nhl Protein Nhl-2 Is A Co-Factor In The Nuclear And Somatic Rnai Pathways In C. Elegans, Gregory M. Davis, Shikui Tu, Jacqueline A. Wilce, Julie M. Claycomb, Zhiping Weng, Peter R. Boag 2018 Federation University

The Trim-Nhl Protein Nhl-2 Is A Co-Factor In The Nuclear And Somatic Rnai Pathways In C. Elegans, Gregory M. Davis, Shikui Tu, Jacqueline A. Wilce, Julie M. Claycomb, Zhiping Weng, Peter R. Boag

Program in Bioinformatics and Integrative Biology Publications and Presentations

Proper regulation of germline gene expression is essential for fertility and maintaining species integrity. In the C. elegans germline, a diverse repertoire of regulatory pathways promote the expression of endogenous germline genes and limit the expression of deleterious transcripts to maintain genome homeostasis. Here we show that the conserved TRIM-NHL protein, NHL-2, plays an essential role in the C. elegans germline, modulating germline chromatin and meiotic chromosome organization. We uncover a role for NHL-2 as a co-factor in both positively (CSR-1) and negatively (HRDE-1) acting germline 22G-small RNA pathways and the somatic nuclear RNAi pathway. Furthermore, we demonstrate that NHL-2 ...


Bio Buzz Newsletter, Issue 16, December 2018, Department of Biology 2018 Denison University

Bio Buzz Newsletter, Issue 16, December 2018, Department Of Biology

Biology Buzz Newsletter

No abstract provided.


Understanding The Impacts Of Current And Future Environmental Variation On Central African Amphibian Biodiversity, Courtney A. Miller 2018 University of New Orleans

Understanding The Impacts Of Current And Future Environmental Variation On Central African Amphibian Biodiversity, Courtney A. Miller

University of New Orleans Theses and Dissertations

Global climate change is projected to impact multiple levels of biodiversity by imposing strong selection pressures on existing populations, triggering shifts in species distributions, and reorganizing entire communities. The Lower Guineo-Congolian region in central Africa, a reservoir for amphibian diversity, is predicted to be severely affected by future climate change through rising temperatures and greater variability in rainfall. Geospatial modelling can be used to assess how environmental variation shapes patterns of biological variation – from the genomic to the community level – and use these associations to predict patterns of biological change across space and time. The overall goal of this dissertation ...


Legacy Habitat Suitability Of Eastern Oysters (Crassostrea Virginica) In Louisiana: A Prelude To Mississippi River Delta Freshwater Diversions, Tasia MV Denapolis 2018 University of New Orleans

Legacy Habitat Suitability Of Eastern Oysters (Crassostrea Virginica) In Louisiana: A Prelude To Mississippi River Delta Freshwater Diversions, Tasia Mv Denapolis

University of New Orleans Theses and Dissertations

The Louisiana oyster industry is greatly impacted by freshwater and sediment diversions that are part of the effort to restore the state’s coastline. A habitat suitability index (HSI) proposes species-habitat relationships that can be instrumental in creating impact assessments and suitability predictions for management as new diversions are implemented. An oyster (Crassostrea virginica) HSI was developed using three variables crucial to oyster sustainability: average annual salinity, minimum monthly salinity, and average salinity during the spawning season. These Legacy HSI visualizations show annual fluctuations in the distribution of zones suitable for oyster cultivation prior to proposed diversions in Pontchartrain and ...


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