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Superresolution Imaging Identifies That Conventional Trafficking Pathways Are Not Essential For Endoplasmic Reticulum To Outer Mitochondrial Membrane Protein Transport., Kyle Salka, Shivaprasad Bhuvanendran, Kassandra Wilson, Petros Bozidis, Mansi Mehta, Kristin Rainey, Hiromi Sesaki, George H Patterson, Jyoti K. Jaiswal, Anamaris M. Colberg-Poley 2017 George Washington University

Superresolution Imaging Identifies That Conventional Trafficking Pathways Are Not Essential For Endoplasmic Reticulum To Outer Mitochondrial Membrane Protein Transport., Kyle Salka, Shivaprasad Bhuvanendran, Kassandra Wilson, Petros Bozidis, Mansi Mehta, Kristin Rainey, Hiromi Sesaki, George H Patterson, Jyoti K. Jaiswal, Anamaris M. Colberg-Poley

Integrative Systems Biology Faculty Publications

Most nuclear-encoded mitochondrial proteins traffic from the cytosol to mitochondria. Some of these proteins localize at mitochondria-associated membranes (MAM), where mitochondria are closely apposed with the endoplasmic reticulum (ER). We have previously shown that the human cytomegalovirus signal-anchored protein known as viral mitochondria-localized inhibitor of apoptosis (vMIA) traffics from the ER to mitochondria and clusters at the outer mitochondrial membrane (OMM). Here, we have examined the host pathways by which vMIA traffics from the ER to mitochondria and clusters at the OMM. By disruption of phosphofurin acidic cluster sorting protein 2 (PACS-2), mitofusins (Mfn1/2), and dynamin related protein 1 ...


Bridging Post-Wildfire Communication Gaps Between Managers, Researchers, And Local Communities, Including A Biological Soil Crust Case Study, Hilary Louise Whitcomb 2017 Utah State University

Bridging Post-Wildfire Communication Gaps Between Managers, Researchers, And Local Communities, Including A Biological Soil Crust Case Study, Hilary Louise Whitcomb

All Graduate Theses and Dissertations

Following a wildfire, land management agencies act quickly to protect ecosystem services. We don't currently understand how post-wildfire managers make trade-off decisions in these tight timelines, or if these decisions reflect current science. Using Brunson’s (2014) social-ecological systems multi-scalar model, surveys assessed manager opinions about post-wildfire projects, perceptions of stakeholder opinions, and ability or willingness to consider new science results. Public surveys asked local citizens their opinions about post-wildfire projects. Manager perceptions were measured through semi-structured phone interviews (n = 8) and a structured online survey (n = 256). Public surveys were mailed to 1,000 (971 deliverable, n = 152 ...


Body Size Regulation Via Bmp Signaling In Caenorhabditis Elegans, Uday Madaan 2017 The Graduate Center, City University of New York

Body Size Regulation Via Bmp Signaling In Caenorhabditis Elegans, Uday Madaan

All Graduate Works by Year: Dissertations, Theses, and Capstone Projects

The body size of an organism can be a crucial determinant of access to nutrition, reproductive success and overall survival in the wild. However, how body size of an individual is determined is incompletely understood. Body size is a complex trait determined by multiple pathways and genes, making it difficult to understand the role of individual genes and pathways in determining overall size. In Caenorhabditis elegans, a homolog of Bone Morphogenetic Proteins (BMP) is a major regulator of body size; functional loss of DBL-1 leads to a small body size. Due to a drastic change in body size in dbl-1 ...


The P53 Independent Functions Of Estrogen-Activated Mdm2 In Cell Signaling And Mammary Architecture, Nandini Kundu 2017 The Graduate Center, City University of New York

The P53 Independent Functions Of Estrogen-Activated Mdm2 In Cell Signaling And Mammary Architecture, Nandini Kundu

All Graduate Works by Year: Dissertations, Theses, and Capstone Projects

Estrogen receptor positive (ER+) breast cancers often have MDM2 overexpression indicating a critical role for MDM2 in breast cancer tumorigenesis. The cancer genome atlas (TCGA) found that increased MDM2 expression is one of the four pathways that correlate with all breast cancer subtypes. MDM2 is mainly known as the negative regulator of wild type p53. However, aggressive breast cancers often have MDM2 overexpression and mutant p53 (mtp53). We previously reported that MDM2 provides an estrogen-mediated proliferative advantage to MCF-7 breast cancer cells (ER+, MDM2 overexpression, wild type p53), independent of wild type p53 in both 2D and 3D culture conditions ...


Anthropogenic Noise Changes Arthropod Abundances, Jessie P. Bunkley, Christopher J.W. McClure, Akito Y. Kawahara, Clinton D. Francis, Jesse R. Barber 2017 Boise State University

Anthropogenic Noise Changes Arthropod Abundances, Jessie P. Bunkley, Christopher J.W. Mcclure, Akito Y. Kawahara, Clinton D. Francis, Jesse R. Barber

Jesse R. Barber

Anthropogenic noise is a widespread and growing form of sensory pollution associated with the expansion of human infrastructure. One specific source of constant and intense noise is that produced by compressors used for the extraction and transportation of natural gas. Terrestrial arthropods play a central role in many ecosystems, and given that numerous species rely upon airborne sounds and substrate-borne vibrations in their life histories, we predicted that increased background sound levels or the presence of compressor noise would influence their distributions. In the second largest natural gas field in the United States (San Juan Basin, New Mexico, USA), we ...


Analysis For Science Librarians Of The 2016 Nobel Prize In Physiology Or Medicine: The Life And Work Of Yoshinori Ohsumi, Neyda Gilman 2017 Selected Works

Analysis For Science Librarians Of The 2016 Nobel Prize In Physiology Or Medicine: The Life And Work Of Yoshinori Ohsumi, Neyda Gilman

Neyda Gilman

Autophagy is a cellular process of destruction and recycling. Cellular materials are broken down and recycled as needed, providing the body a way to remove unwanted material while also providing the means to create new needed items. The importance of this process and its possible role in numerous diseases is why Yoshinori Ohsumi has been awarded a 2016 Noble Prize. Ohsumi has been awarded the 2016 Nobel in Physiology or Medicine for his “discoveries of mechanisms for autophagy and thus paving the way for the exciting field of autophagy research” (Nobelprize.org “Press release: The 2016 Nobel Prize in Physiology ...


Ethical Concerns For Assisted Reproductive Technologies, Olga Najera 2017 Abilene Christian University

Ethical Concerns For Assisted Reproductive Technologies, Olga Najera

Dialogue & Nexus

The development of assisted reproductive technologies has provided new options for infertile couples in their pursuit of parenthood. As a result of the successful implementation of in vitro fertilization (IVF), gestational surrogacy is now an alternative. Other technology, such as genetic enhancement, could potentially become available for human beings soon; however, numerous ethical concerns have been raised by the fact that it requires germline engineering. The concerns brought about by these new reproductive technologies will be addressed in light of the teachings of the Roman Catholic Church and of the following ethical theories: Kantian, evolutionary, utilitarian, and virtue ethics.


The Impact Of Anthropocentrism On Christian Environmentalism, Alexis Grasse 2017 Abilene Christian University

The Impact Of Anthropocentrism On Christian Environmentalism, Alexis Grasse

Dialogue & Nexus

This paper will discuss the effects of anthropocentrism in Christian theology, doctrine, and environmentalism. The development and history of Christian environmentalism will be examined, with emphasis on the time since the 1960s, when environmentalism came to the forefront in the Western world. Alternative interpretations and worldviews, mainly ecocentrism and biocentrism, will be considered and compared to the prevalent anthropocentric view. I will close with a presentation of two possible means for developing a Christian ecological theology without anthropocentrism. An environmental position most coherent with Christian principles will be left open to the reader; my purpose is to examine the impact ...


Revolution In Ideology: Crafting A Holistic Scientific Dialectic, Nathan Neill 2017 Abilene Christian University

Revolution In Ideology: Crafting A Holistic Scientific Dialectic, Nathan Neill

Dialogue & Nexus

Ideology drives scientific research far more than is acknowledged. Since science itself is conducted by individuals, each scientist has a biased conception of themselves and their surroundings relative to the rest of the universe, even if it is never explicated. This sense of relation to the greater universe is what defines the ideology of the individual. It is this sense of relation and self that creates the individual, who goes on to investigate the natural world by the scientific method. In this paper I will examine extant scientific ideology, particularly in Western science, and propose changes that could be helpful.


False Pretexts Of Altruism And The Truth About Cooperation, Selvin Villeda 2017 Abilene Christian University

False Pretexts Of Altruism And The Truth About Cooperation, Selvin Villeda

Dialogue & Nexus

Without deeper analysis, altruism seems to be alive and present in our world today. However, most of what is called altruism is really mere cooperation. True altruism cannot be achieved unless you directly give up your life without receiving any benefit. Only by analyzing such acts and exploring the true motives of these acts, can we see that 1) biological influences (such as genetic relatedness) and 2) social components stemming from reciprocity are what determine these cooperative actions. We cooperate together for greater overall fitness of society. Through cooperation we can have a striving community that can grow together. Ultimately ...


An Analysis Of Altruism, Sarah Siemens 2017 Abilene Christian University

An Analysis Of Altruism, Sarah Siemens

Dialogue & Nexus

Scientists, freethinkers, and philosophers have attempted to find an explanation of the role of altruism in a natural world that is compatible to the dominantly accepted Darwinian principle of natural selection. Many postulates have been developed in an attempt to explain how self-sacrificial behaviors are cohesive within the “survival of the fittest” ideology. This has caused many scientists to broaden the definition of altruism to understand its components in the physical world. In order to understand how absolute altruism is solely found through God’s love, it is necessary to examine each subset of scientific altruism to reveal their differences ...


Down Syndrome, The Image Of God, And Personhood, Paris Webb 2017 Abilene Christian University

Down Syndrome, The Image Of God, And Personhood, Paris Webb

Dialogue & Nexus

People with Down syndrome help Christians understand what being made in the image of God truly means. After describing Down syndrome, we will examine the different views of the image of God and how these relate to people with Down syndrome. Another approach will be to define personhood in light of God’s image and relate it to Down syndrome. We will use the principles held by the L’Arche community as an exemplar in this discussion to demonstrate that those with Down syndrome encourage us to expand our understanding of the image of God. Consequently, Down’s persons allow ...


Livin’ On A Prayer: An Analysis Of Intercessory Prayer Studies, Savannah Vincent 2017 Abilene Christian University

Livin’ On A Prayer: An Analysis Of Intercessory Prayer Studies, Savannah Vincent

Dialogue & Nexus

A meta-analysis of intercessory prayer studies was done. Current studies fail to account for the numerous variables and limitations posed by these studies; nevertheless, it is possible to reach the conclusion that the prospect of prayer as an alternative medicine is, at best, limited. The boundaries of faith and science need to be respected. The essential takeaway from this discussion is to look deeper into what sounds like simple and well-designed scientific studies on faith. These studies are often either inconclusive or have varying results when compared to similar studies.


Human Evolution And Divine Agency, Alexandra Rakestraw 2017 Abilene Christian University

Human Evolution And Divine Agency, Alexandra Rakestraw

Dialogue & Nexus

Modern Christians often find themselves at a crossroads when confronted with the two predominant understandings of human and universal origins. Plain sense readings of Genesis lead many to believe in a historical six-day creation that occurred in the past ten thousand years while proponents on the other side of the spectrum use current scientific understanding to support a creation that occurs through evolutionary means. How one views human origins has a profound impact on one’s concept of how God works in the cosmos. In this paper, I will lay out a background to better understand the characters of Adam ...


Deism Revisited: A Modern Approach, Tina Johnson 2017 Abilene Christian University

Deism Revisited: A Modern Approach, Tina Johnson

Dialogue & Nexus

An evaluation of the history of Deism and its modern counterpart, Moralistic Therapeutic Deism, in light of Theistic Naturalism is done in order to place the several forms of deism into a proper context in modern society. My hoped for outcome is that perhaps we can view Deism as a progressive rather than an archaic belief system that still has a purpose in American religious culture.


Moral Awareness, Original Sin And The Atonement, Tanner Gregory 2017 Abilene Christian University

Moral Awareness, Original Sin And The Atonement, Tanner Gregory

Dialogue & Nexus

I will explore how evolution impacts the Christian notion of The Fall of man, and, ultimately, the atonement. Various theories of atonement in the Christian tradition generally assume universal and individual sinfulness in humanity. In some cases, this sinfulness is thought to be the result of a distinct moment of rebellion against God, and is transmitted to all of the descendants of Adam. Here, atonement involves Christ’s sacrifice as the means liberate humanity from the bondage of our sinful nature. Evolution collides with these traditional models. Instead of a creation originally void of death and later corrupted by sin ...


Mollifying Neuroscience And Christian Faith: An Emergent Monistic Claim For Free Will And The Soul, Paul Figel 2017 Abilene Christian University

Mollifying Neuroscience And Christian Faith: An Emergent Monistic Claim For Free Will And The Soul, Paul Figel

Dialogue & Nexus

Modern neuroscience makes it difficult for one to support a case for substance dualism regarding the existence of a soul and free will. The neuroscientific evidence stems from several experiments in which test subjects were instructed to perform a simple voluntary movement. Scientists consistently observed neurological antecedents preceding the subject’s conscious decision to perform the action. An examination of these experiments and the conclusions drawn will show several key inconsistencies that weaken the extreme anti-conscious will claim. However, it is important to not reject the neurological evidence against substance dualism, but instead discover a new perspective (e.g. emergent ...


End Of Life Care For The Incarcerated, Codie Robinson 2017 Abilene Christian University

End Of Life Care For The Incarcerated, Codie Robinson

Dialogue & Nexus

As the prison population ages, a new need has come to light – caring for those who are in the final stage of life. This paper will examine the current end of life services provided to those in prison throughout the United States. After a general awareness of the system is presented, a more complete discussion of end of life care for prisoners will be considered, in light of ethics, social justice, and the Christian perspective. The two care options presented, hospice care and compassionate release, are observed through these lenses. In order to make a decision on how to care ...


Race Relations: A Dialogue Between Science And Theology On The Basis Of Race, Shanice Latham 2017 Abilene Christian University

Race Relations: A Dialogue Between Science And Theology On The Basis Of Race, Shanice Latham

Dialogue & Nexus

When the topic of race is breached the emotions expressed can range from extreme feelings of guilt to extreme feelings of anger. Why is a word that is, today, commonly associated with a person’s skin color and other physical characteristics responsible for such strong emotional reactions? Much of the violence, poverty, injustice, and hurt in the world has been and is caused by racial division. With the continued use of such an arbitrary system as race these issues will continue to persist and deteriorate. This paper will explore the origin, as well as scientific and theological perspectives of race ...


Feminism In Biology And Belief, Rachel Hurst 2017 Abilene Christian University

Feminism In Biology And Belief, Rachel Hurst

Dialogue & Nexus

As feminism has become more hotly-contested in today’s society, the need to analyze the movement’s claims from a scientific and theological perspective has developed. Labor statistics and sociological research reveal that income inequality persists between the sexes. Neuroscience and evolutionary psychology show that subtle differences exist between male and female brains, and these slight variations can potentially be traced to the differing selective pressures between the genders. Ultimately, the biological differences that favor power differentials must be overcome to remedy inequality and injustice. Although Christians have historically upheld these differences and viewed women as inferior, a more modern ...


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