Echinacea Sanguinea And Echinacea Pallida Extracts Stimulate Glucuronidation And Basolateral Transfer Of Bauer Alkamides 8 And 10 And Ketone 24 And Inhibit P-Glycoprotein Transporter In Caco-2 Cells, 2016 Iowa State University
Echinacea Sanguinea And Echinacea Pallida Extracts Stimulate Glucuronidation And Basolateral Transfer Of Bauer Alkamides 8 And 10 And Ketone 24 And Inhibit P-Glycoprotein Transporter In Caco-2 Cells, Zhiyi Qiang, Catharine Hauck, Joe-Ann Mccoy, Mark P. Widrlechner, Manju B. Reddy, Patricia A. Murphy, Suzanne Hendrich
Manju B. Reddy
The use of Echinacea as a medicinal herb is prominent in the United States, and many studies have assessed the effectiveness of Echinacea as an immunomodulator. We hypothesized that Bauer alkamides 8, 10, and 11 and ketone 24 were absorbed similarly either as pure compounds or from Echinacea sanguinea and Echinacea pallida ethanol extracts, and that these Echinacea extracts could inhibit the P-glycoprotein transporter in Caco-2 human intestinal epithelial cells. Using HPLC analysis, the permeation rate of Bauer alkamides by passive diffusion across Caco-2 cells corresponded with compound hydrophilicity (alkamide 8 > 10 > 11), independent of the plant extract matrix. Both ...
Evolutionary Genomics And Adaptive Evolution Of The Hedgehog Gene Family (Shh, Ihh And Dhh) In Vertebrates, 2016 Universidade do Porto - Portugal
Evolutionary Genomics And Adaptive Evolution Of The Hedgehog Gene Family (Shh, Ihh And Dhh) In Vertebrates, Joana Pereira, Warren E. Johnson, Stephen J. O'Brien, Erich D. Jarvis, Guojie Zhang, M. Thomas P. Gilbert, Vitor Vasconcelos, Agostinho Antunes
The Hedgehog (Hh) gene family codes for a class of secreted proteins composed of two active domains that act as signalling molecules during embryo development, namely for the development of the nervous and skeletal systems and the formation of the testis cord. While only one Hh gene is found typically in invertebrate genomes, most vertebrates species have three (Sonic hedgehog – Shh; Indian hedgehog – Ihh; and Desert hedgehog – Dhh), each with different expression patterns and functions, which likely helped promote the increasing complexity of vertebrates and their successful diversification. In this study, we used comparative genomic and adaptive evolutionary analyses to ...
Mathematical Modeling In Collaborative Courses: The Soup To Nuts Experience, 2016 Hampshire College
Mathematical Modeling In Collaborative Courses: The Soup To Nuts Experience, Sarah Hews, Christina Cianfrani
Annual Symposium on Biomathematics and Ecology: Education and Research
No abstract provided.
Working With The Remains In Cambodia: Skeletal Analysis And Human Rights After Atrocity, 2016 Michigan State University
Working With The Remains In Cambodia: Skeletal Analysis And Human Rights After Atrocity, Julie M. Fleischman
Genocide Studies and Prevention: An International Journal
This essay will discuss the research being conducted on Khmer Rouge-era human skeletal remains in Cambodia, and the implications of this work. First, the Cambodian project to conserve and analyze the remains at the Choeung Ek Genocidal Center (Choeung Ek) will be briefly discussed. This exceptional undertaking was the first complete scientific analysis of human remains from a Cambodian mass gravesite. Second, the author’s independent research at Choeung Ek and a collaborative project at another mass gravesite will be reviewed. The author’s research focuses on the traumatic injuries and demographics of the remains at Choeung Ek, while also ...
The Subject Librarian Newsletter, Interdisciplinary Studies, Fall 2016, 2016 University of Central Florida
The Subject Librarian Newsletter, Interdisciplinary Studies, Fall 2016, Corinne Bishop
No abstract provided.
Biomass And Biofuels In Maine: Estimating Supplies For Expanding The Forest Products Industry, 2016 University of Maine
Biomass And Biofuels In Maine: Estimating Supplies For Expanding The Forest Products Industry, Jonathan Rubin, Kate Dickerson, Jacob Kavkewitz
This paper estimates the renewable energy potential of Maine’s forest resources, and how much energy these resources could potentially provide the state. Using the most recent state-specific data available, and a methodology similar to the Billion Tons Report, we find that ethanol production from Maine’s forest residues could potentially provide 18% of Maine’s transportation (gasoline) fuels with a fermentation wood to ethanol process. Making Fischer-Tropsch diesel (F-T diesel) using forest residues can replace 39% of Maine’s petro-diesel consumption. Actual levels of biofuels that can be produced will depend on conversion factors and forestry residue removals that ...
A Quantitative Analysis Of Hugelkultur And Its Potential Application On Karst Rocky Desertified Areas In China, 2016 Western Kentucky University
A Quantitative Analysis Of Hugelkultur And Its Potential Application On Karst Rocky Desertified Areas In China, Megan Laffoon
Honors College Capstone Experience/Thesis Projects
A type of environmental degradation, karst rocky desertification (KRD) refers to areas where the soil loss exposes the bedrock and reduces the land’s ability to sustain life and is particularly widespread through the vast karst area of rural southwest China. Hugelkultur is a permaculture method that harnesses the wood decomposition process by burying logs beneath soil. We proposed that hugel beds will demonstrate a higher water holding capacity and enhance soil development, in a way that may show promise as a potential method to help alleviate problems of KRD. Soil samples were taken from hugel plots, non-hugel plots, and ...
Dietary Weight Loss Advice In Us Health Magazines And Its Relation To Ancestral Diet, 2016 Rockhurst University
Dietary Weight Loss Advice In Us Health Magazines And Its Relation To Ancestral Diet, Risa J. Stein, Marium A. Choudhry, Thomas J. Murray Jr.
Journal of Evolution and Health
As rates of overweight and obesity have risen in the US, the public has sought effective strategies for weight loss through dietary modification. A proliferation of processed foods and changing governmental nutrition guidelines have both impacted dietary intake patterns. While physicians are considered respectable sources of weight-loss information, increasingly the public has turned to the media, particularly magazines, for weight loss advice. This study investigated the dietary recommendations found in the five leading US health-related magazines and compared those recommendations to ancestral diets. With a couple notable exceptions, leading health magazines present consistent recommendations for dietary modifications to promote weight ...
Comparative Genomics, Transcriptomics, And Physiology Distinguish Symbiotic From Free-Living Chlorella Strains, 2016 University of Nebraska-Lincoln
Comparative Genomics, Transcriptomics, And Physiology Distinguish Symbiotic From Free-Living Chlorella Strains, Cristian F. Quispe, Olivia Sonderman, Maya Khasin, Wayne R. Riekhof, James Van Etten, Kenneth Nickerson
Kenneth Nickerson Papers
Most animal–microbe symbiotic interactions must be advantageous to the host and provide nutritional benefits to the endosymbiont. When the host provides nutrients, it can gain the capacity to control the interaction, promote self-growth, and increase its fitness. Chlorella-like green algae engage in symbiotic relationships with certain protozoans, a partnership that significantly impacts the physiology of both organisms. Consequently, it is often challenging to grow axenic Chlorella cultures after isolation from the host because they are nutrient fastidious and often susceptible to virus infection. We hypothesize that the establishment of a symbiotic relationship resulted in natural selection for nutritional and ...
Botanical Therapeutics In The Modern World, 2016 CUNY Hostos Community College
Botanical Therapeutics In The Modern World, Vyacheslav Dushenkov, Brittany L. Graf, Mary Ann Lila
Publications and Research
Plants are the source of a broad spectrum of biologically active phytochemicals. For effective defense against pathogens and abiotic stress, plants have developed complicated chemical strategies with different mechanisms of action. By harnessing these phytochemicals, humans have used plants for medicinal purposes for over 30,000 years, and they remain a valuable source for the development of modern therapeutics. Plant-derived materials are utilized as pharmaceuticals, botanical drugs, dietary supplements (nutraceuticals), functional food ingredients, and cosmeceuticals. The Global Institute for Bioexploration (GIBEX), an international conglomerate of researchers, is involved in multiple botanical therapeutics discovery and development programs.
Directional Preference In Drosophila Melanogaster, 2016 Western Oregon University
Directional Preference In Drosophila Melanogaster, Taylor James, Michael Baltzley, Eli Zachary, Spicie Davis, Kristin Latham
Diverse organisms have been shown to use the Earth’s magnetic field for orientation and navigation, but the mechanisms underlying magnetoreception are still poorly understood. Recent research on magnetoreception has focused on the fruit fly Drosophila melanogaster primarily because of its role as a model organism for understanding the genetic mechanisms underlying behavioral traits. While current research suggests that Drosophila might be able to detect and orient to magnetic fields, different studies offer contradictory results. In this study, we used a Y-maze and selective breeding to attempt to create a population of fruit flies that display a robust magnetic orientation ...
Ocean Acidification And Predator-Prey Relations: Correlating Disruption Of Predator Avoidance With Chemosensory Deficits, Alexandra Fw Sidun
Student Research Day Abstracts and Posters
One of the most destructive effects of global climate change is the increased carbon sequestering and consequential acidification of our world’s oceans. The impacts of ocean acidification on marine organisms are still relatively unknown, especially effects on behavioral ecology. Avoiding predation has emerged from recent behavioral ecology literature as a critical feature in the life history of a wide array of animal species; experiments on marine fishes suggest acidic water compromises their predator-avoidance abilities. Recent assays in our lab suggest predator-induced behavior is reduced by weakly acidic water. These experiments do not address the potential factor of generalized malaise ...
Chapman University 2016 Environmental Audit: Residence Life Dining Services Equipment, 2016 Chapman University
Chapman University 2016 Environmental Audit: Residence Life Dining Services Equipment, Alexandra Fw Sidun, Devon T. Bloss
Student Research Day Abstracts and Posters
Chapman University accommodates over 1700 student meal plans per day through the on-campus dining services provided by Sodexo Restaurant Services. The commercial-grade kitchens found in the Randall Dining Commons (RDC) of Sandhu Conference Center are frequently used to prepare food for students for every meal, seven days a week. The RDC kitchen facility has staff working around the clock and high consumption electrical, water, and gas appliances constantly running to parallel the high demand. The frequent use of commercial kitchen appliances results in an enormous consumption of energy and water resources leading to comparably high utility bills. Measuring the energy ...
Changes In Floristic Composition In The State Forests In Worcester County (Massachusetts) Over 34 Years, Flor A. Monroe
International Development, Community and Environment (IDCE)
CHANGES IN FOREST DIVERSITY OF STATE FOREST IN WORCESTER COUNTY, MASSACHUSETTS, OVER 34 YEARS PERIOD
The forest in Massachusetts has changed since the earliest colonial settlement and today the floristic composition is more homogeneous. This study investigates the potential change in the floristic composition over thirty years in Worcester County State Forests. Shannon, richness and evenness indices for two periods were compared, and Jaccard index was used to analyze similarity in composition between the periods. The possible influence of severe weather events was also analyzed.
It was found Changes in the floristic composition, but the magnitude of the changes ...
Development Of A Decision Support System For Post Mining Land Use On Abandoned Surface Coal Mines In Appalachia, Matthew Zimmerman
International Development, Community and Environment (IDCE)
Decision support systems are diverse and have been used to solve multiple problems ranging from the complex to the simple. With the complexity of environmental decisions today, these systems provide a logic based approach to evaluating and choosing environmental solutions. Abandoned mining lands (AML) are an issue for the environment in the Appalachian region. Given this a decision support system was designed using previously created frameworks and indices from other systems created. The system is comprised of two main sections, selecting the ideal post-mining land-use (PMLU), and maximizing the potential of land to be reclaimed under budgetary constraints. This system ...
Characterization Of Induced Rnai Silencing Of Vaccinia Virus Essential Genes, 2016 University of Connecticut
Characterization Of Induced Rnai Silencing Of Vaccinia Virus Essential Genes, Kewa Jiang
Honors Scholar Theses
Vaccinia virus (VACV) is a large double-stranded DNA virus and the prototypical member of the family Poxviridae and is most notable for its use as the vaccine that eradicated smallpox (variola virus). More recently, VACV has been used to develop recombinant vaccines and immunotherapies. However, many of these processes require VACV replication to be tightly controlled. RNA interference (RNAi) is a powerful tool for in vitro silencing of mRNAs that are complementary to 19-21 base pairs (bp) of double-stranded RNA (dsRNA). This project outlines the design and preliminary analysis of two inducible RNAi silencing constructs targeting multiple VACV essential genes ...
Variation In Vegetation And Microbial Linkages With Slope Aspect In A Montane Temperate Hardwood Forest, 2016 Marshall University
Variation In Vegetation And Microbial Linkages With Slope Aspect In A Montane Temperate Hardwood Forest, Frank S. Gilliam, Radim Hedl, Marketa Chudomelova, Rebecca L. Mcculley, Jim Nelson
Frank S. Gilliam
Plant ecologists have long been interested in aspect-related contrasts of montane forests. Few studies have assessed correlation (linkage) among vegetation strata; fewer have included soil microbial communities. This study assessed contrasts in overstory, spring herbaceous, and soil microbial communities between northeast (NE) - and southwest (SW) -facing slopes in a second-growth West Virginia hardwood forest. We addressed three questions: (1) how do soil microbial, herbaceous layer, and overstory communities vary with slope aspect? (2) do forest vegetation strata and soil microbial communities exhibit linkage? (3) do biotic relationships and linkage vary with slope aspect? Moisture, organic matter, pH, soil NO3 ...
Nutrient Limitation In Three Lowland Tropical Forests In Southern China Receiving High Nitrogen Deposition: Insights From Fine Root Responses To Nutrient Additions, Feifei Zhu, Muneoki Yoh, Frank S. Gilliam, Xiankai Lu, Jiangming Mo
Frank S. Gilliam
Elevated nitrogen (N) deposition to tropical forests may accelerate ecosystem phosphorus (P) limitation. This study examined responses of fine root biomass, nutrient concentrations, and acid phosphatase activity (APA) of bulk soil to five years of N and P additions in one old-growth and two younger lowland tropical forests in southern China. The old-growth forest had higher N capital than the two younger forests from long-term N accumulation. From February 2007 to July 2012, four experimental treatments were established at the following levels: Control, N-addition (150 kg N ha–1 yr–1), P-addition (150 kg P ha–1 yr–1) and ...
Spatial Variation In Carbon And Nitrogen In Cultivated Soils In Henan Province, China: Potential Effect On Crop Yield, Xuelin Zhang, Qun Wang, Frank S. Gilliam, Yilun Wang, Feina Cha, Chaohai Li
Frank S. Gilliam
Improved management of soil carbon (C) and nitrogen (N) storage in agro-ecosystems represents an important strategy for ensuring food security and sustainable agricultural development in China. Accurate estimates of the distribution of soil C and N stores and their relationship to crop yield are crucial to developing appropriate cropland management policies. The current study examined the spatial variation of soil organic C (SOC), total soil N (TSN), and associated variables in the surface layer (0–40 cm) of soils from intensive agricultural systems in 19 counties within Henan Province, China, and compared these patterns with crop yield. Mean soil C ...
A Continental Analysis Of Ecosystem Vulnerability To Atmospheric Nitrogen Deposition, 2016 Marshall University
A Continental Analysis Of Ecosystem Vulnerability To Atmospheric Nitrogen Deposition, Samuel M. Simkin, Edith B. Allen, William D. Bowman, Christopher M. Clark, Jayne Belnap, Matthew L. Brooks, Brian S. Cade, Scott L. Collins, Linda H. Geiser, Frank S. Gilliam, Sarah E. Jovan, Linda H. Pardo, Bethany K. Schulz, Carly J. Stevens, Katharine N. Suding, Heather L. Throop, Donald M. Waller
Frank S. Gilliam
Atmospheric nitrogen (N) deposition has been shown to decrease plant species richness along regional deposition gradients in Europe and in experimental manipulations. However, the general response of species richness to N deposition across different vegetation types, soil conditions, and climates remains largely unknown even though responses may be contingent on these environmental factors. We assessedtheeffectofNdepositiononherbaceousrichnessfor15,136 forest, woodland, shrubland, and grassland sites across the continental United States, to address how edaphic and climatic conditions altered vulnerability to this stressor. In our dataset, with N deposition ranging from 1 to 19 kg N·ha−1·y−1, we found a unimodal ...