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Atomistic Simulations And Network-Based Modeling Of The Hsp90-Cdc37 Chaperone Binding With Cdk4 Client Protein: A Mechanism Of Chaperoning Kinase Clients By Exploiting Weak Spots Of Intrinsically Dynamic Kinase Domains, John Czemeres, Kurt Buse, Gennady M. Verkhivker 2017 Chapman University

Atomistic Simulations And Network-Based Modeling Of The Hsp90-Cdc37 Chaperone Binding With Cdk4 Client Protein: A Mechanism Of Chaperoning Kinase Clients By Exploiting Weak Spots Of Intrinsically Dynamic Kinase Domains, John Czemeres, Kurt Buse, Gennady M. Verkhivker

Mathematics, Physics, and Computer Science Faculty Articles and Research

A fundamental role of the Hsp90 and Cdc37 chaperones in mediating conformational development and activation of diverse protein kinase clients is essential in signal transduction. There has been increasing evidence that the Hsp90-Cdc37 system executes its chaperoning duties by recognizing conformational instability of kinase clients and modulating their folding landscapes. The recent cryo-electron microscopy structure of the Hsp90-Cdc37- Cdk4 kinase complex has provided a framework for dissecting regulatory principles underlying differentiation and recruitment of protein kinase clients to the chaperone machinery. In this work, we have combined atomistic simulations with protein stability and network-based rigidity decomposition analyses to characterize dynamic ...


Virtual Reality As A Training Tool To Treat Physical Inactivity In Children, Adam W. Kiefer, David Pincus, Michael J. Richardson, Gregory D. Myer 2017 Cincinnati Children’s Hospital Medical Center

Virtual Reality As A Training Tool To Treat Physical Inactivity In Children, Adam W. Kiefer, David Pincus, Michael J. Richardson, Gregory D. Myer

Psychology Faculty Articles and Research

Lack of adequate physical activity in children is an epidemic that can result in obesity and other poor health outcomes across the lifespan. Physical activity interventions focused on motor skill competence continue to be developed, but some interventions, such as neuromuscular training (NMT), may be limited in how early they can be implemented due to dependence on the child’s level of cognitive and perceptual-motor development. Early implementation of motor-rich activities that support motor skill development in children is critical for the development of healthy levels of physical activity that carry through into adulthood. Virtual reality (VR) training may be ...


Science And Sentiment: Affecting Change In Environmental Awareness, Attitudes, And Actions Through The Daily Nature Project, Elizabeth D. Haynes Poronsky 2017 The Overfield School

Science And Sentiment: Affecting Change In Environmental Awareness, Attitudes, And Actions Through The Daily Nature Project, Elizabeth D. Haynes Poronsky

The STEAM Journal

Knowledge about what motivates pro-environmental behavior is important to organizations that seek to encourage environmental stewardship. Research suggests that targeting emotions and beliefs about nature can be more effective in changing environmental actions than increasing knowledge. Daily Nature, a site on the social media platform Facebook, features a daily nature photograph, a quote from a notable historical person and a related lyrical written passage. The popularity of this site lends credence to the appeal of interdisciplinary formats, and underscores the benefits of encouraging emotional and aesthetic ties to nature.


Can Mine Reclamation With An Exotic Grass Species Precede Successful Restoration In Intermountain Grasslands? A Case Study With Agropyron Cristatum., Mark Mariano 2017 Montana Tech

Can Mine Reclamation With An Exotic Grass Species Precede Successful Restoration In Intermountain Grasslands? A Case Study With Agropyron Cristatum., Mark Mariano

Graduate Theses & Non-Theses

We performed four experiments to test whether or not native plants germinated with physical and chemical contact with crested wheatgrass (Agropyron cristatum (L.) Gaertn.), a grass species native to Eurasia which has been widely used for mine reclamation in North America. In our study area Butte, Montana, A. cristatum was planted on capped mine waste and, in many cases, has formed a monoculture with a large buildup of leaf litter. We found there to be a much higher mean litter depth on these lands when compared to wild grasslands. Leaf litter proved to be a significant barrier for the establishment ...


Beheading First: On Nabokov's Translation Of Lewis Carroll, Victor Fet 2017 Marshall University

Beheading First: On Nabokov's Translation Of Lewis Carroll, Victor Fet

Victor Fet

Anya v Strane chudes, young Nabokov’s 1923 Russian translation of Alice’s Adventures in Wonderland, contains an intentionally shifted statement “beheading first, sentence later” compared to Lewis Carroll’s “sentence first, verdict later”. The shift is fitting for the 1920s children émigré audience.


Zoological Label As Literary Form, Victor Fet 2017 Marshall University

Zoological Label As Literary Form, Victor Fet

Victor Fet

Nabokov’s work is seen through the unique concept of zoological labels and their language. A label, written by a young naturalist, is a concentrated source of information, detail, and “naming the unnamed”; it reflects three Aristotelian unities (place, time, action).


An Anti-Locust Campaign In Nabokov (And Pushkin), Victor Fet 2017 Marshall University

An Anti-Locust Campaign In Nabokov (And Pushkin), Victor Fet

Victor Fet

Pushkin’s non-apocryphal anti-locust campaign is reflected in Nabokov’s unpublished sequel to The Gift.


Zoological Nomenclature And Kinbote’S Name Of God, Victor Fet 2017 Marshall University

Zoological Nomenclature And Kinbote’S Name Of God, Victor Fet

Victor Fet

In Nabokov’s Pale Fire, Kinbote explains that the Name of God holds priority over Nature, etc. I show that the ‘priority principle’ here can be interpreted in the strict terms of zoological nomenclature.


Notes On Eryx, Omega, And Ata, Victor Fet 2017 Marshall University

Notes On Eryx, Omega, And Ata, Victor Fet

Victor Fet

Observations on several Nabokov’s works (Pale Fire, Lolita) where geographic or zoological names provide sources for puns and hidden parallels.


T-Time: A Data Repository Of T Cell And Calcium Release-Activated Calcium Channel Activation Imagery, Cody Arbuckle, Milton L. Greenberg, Adrienne Bergh, Rene German, Nick Sirago, Erik J. Linstead 2017 Chapman University

T-Time: A Data Repository Of T Cell And Calcium Release-Activated Calcium Channel Activation Imagery, Cody Arbuckle, Milton L. Greenberg, Adrienne Bergh, Rene German, Nick Sirago, Erik J. Linstead

Mathematics, Physics, and Computer Science Faculty Articles and Research

BACKGROUND: A fundamental understanding of live-cell dynamics is necessary in order to advance scientific techniques and personalized medicine. For this understanding to be possible, image processing techniques, probes, tracking algorithms and many other methodologies must be improved. Currently there are no large open-source datasets containing live-cell imaging to act as a standard for the community. As a result, researchers cannot evaluate their methodologies on an independent benchmark or leverage such a dataset to formulate scientific questions.

FINDINGS: Here we present T-Time, the largest free and publicly available data set of T cell phase contrast imagery designed with the intention of ...


Effects Of Stocking Rate And Botanical Composition On The Physical Characteristics Of The Riparian Zones Of Pastures (A Two-Year Progress Report), Douglas Allen Bear, James R. Russell, Daniel G. Morrical, Mustafa Tufekcioglu, Thomas M. Isenhart, John L. Kovar 2017 Iowa State University

Effects Of Stocking Rate And Botanical Composition On The Physical Characteristics Of The Riparian Zones Of Pastures (A Two-Year Progress Report), Douglas Allen Bear, James R. Russell, Daniel G. Morrical, Mustafa Tufekcioglu, Thomas M. Isenhart, John L. Kovar

Thomas M. Isenhart

Grazing management practices that allow cattle to congregate near pasture streams may result in the loss of vegetative cover and promote accumulation of manure near the streams, increasing the risk of nonpoint source pollution of the stream. The objective of this project was to evaluate the effects of stocking rate of pastures and the botanical composition of the pastures’ riparian zone on the forage sward height and the proportions of bare and manure-covered ground along the banks of pasture streams.


Implementation Of Food Defense Best Practices In Northern U.S. School Nutrition Programs: A Case Study, Carol J. Klitzke, Catherine H. Strohbehn, Susan W. Arendt 2017 Viterbo University

Implementation Of Food Defense Best Practices In Northern U.S. School Nutrition Programs: A Case Study, Carol J. Klitzke, Catherine H. Strohbehn, Susan W. Arendt

Susan W. Arendt

One act of intentional contamination of school meals can quickly harm many children. Food defense guidelines for schools exist; yet previous research has found communication, utility security, and physical security practices are infrequently implemented. A multi-site case study approach obtained a 360-degree assessment of food defense practices in five school districts. Meal production and service were observed, a food defense checklist was completed, and key stakeholders were interviewed. Qualitative analysis of interviews revealed lack of awareness, lack of concern, conflicting priorities, and isolation of food service from other school operations impaired food defense implementation. School security measures protected children, but ...


Food Safety Culture In Onsite Foodservices: Development And Validation Of A Measurement Scale, Ungku Fatimah Ungku Zainal Abidin, Susan W. Arendt, Catherine H. Strohbehn 2017 Universiti Putra Malaysia

Food Safety Culture In Onsite Foodservices: Development And Validation Of A Measurement Scale, Ungku Fatimah Ungku Zainal Abidin, Susan W. Arendt, Catherine H. Strohbehn

Susan W. Arendt

The purpose of this research was to develop and validate a measurement scale for food safety culture in onsite foodservices. Nonsupervisory employees in hospital and school foodservices participated in a two-phase, mixed methods research design process. In phase 1, four focus groups were conducted to identify relevant factors of food safety culture. In phase 2, a survey completed by 582 respondents appeared to validate six food safety culture factors: management and coworkers support, communication, self commitment, environment support, work pressure, and risk judgement. The scale can be used to assess current food safety practices and strategize future food safety improvement ...


Spatial Variation In Carbon And Nitrogen In Cultivated Soils In Henan Province, China: Potential Effect On Crop Yield, Xuelin Zhang, Qun Wang, Frank S. Gilliam, Yilun Wang, Feina Cha, Chaohai Li 2017 Marshall University

Spatial Variation In Carbon And Nitrogen In Cultivated Soils In Henan Province, China: Potential Effect On Crop Yield, Xuelin Zhang, Qun Wang, Frank S. Gilliam, Yilun Wang, Feina Cha, Chaohai Li

Qun Wang

Improved management of soil carbon (C) and nitrogen (N) storage in agro-ecosystems represents an important strategy for ensuring food security and sustainable agricultural development in China. Accurate estimates of the distribution of soil C and N stores and their relationship to crop yield are crucial to developing appropriate cropland management policies. The current study examined the spatial variation of soil organic C (SOC), total soil N (TSN), and associated variables in the surface layer (0–40 cm) of soils from intensive agricultural systems in 19 counties within Henan Province, China, and compared these patterns with crop yield. Mean soil C ...


A Healthy Brain: Use It Or Lose It!, Elizabeth B. Fauth, Maria C. Norton 2017 Utah State University

A Healthy Brain: Use It Or Lose It!, Elizabeth B. Fauth, Maria C. Norton

All Current Publications

Challenging your muscles makes for strong healthy muscles, and challenging your brain cells makes for a strong healthy brain. Build up your brain’s cognitive reserve – create a well-connected, high-capacity brain – through overall healthy behaviors (diet and exercise) and making mentally challenging activities part of your daily life. The more options your brain has to get its signals sent, the better able it is to handle areas of damage. A well-connected brain may be better able to delay or prevent diseases like Alzheimer’s.


Saving Lives Saving Life: Incorporation Of Sustainability In Healthcare, Yelenny Argueta 2017 Georgia State University

Saving Lives Saving Life: Incorporation Of Sustainability In Healthcare, Yelenny Argueta

Georgia State Undergraduate Research Conference

No abstract provided.


Do You Really Want A Hunter-Gatherer Microbiota? Perils And Pitfalls For Your Gut, Michael Ruscio 2017 Dr. Michael Ruscio

Do You Really Want A Hunter-Gatherer Microbiota? Perils And Pitfalls For Your Gut, Michael Ruscio

Journal of Evolution and Health

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The Case For The Long Body, Frank Forencich 2017 Exuberant Animal

The Case For The Long Body, Frank Forencich

Journal of Evolution and Health

No abstract provided.


Niche By Basma Kavanagh, Vivian M. Hansen 2017 University of Calgary

Niche By Basma Kavanagh, Vivian M. Hansen

The Goose

Review of Basma Kavanagh's Niche.


Gosnell Studies And Communicates Ecological Concerns, Aldemaro Romero Jr. 2017 CUNY Bernard M Baruch College

Gosnell Studies And Communicates Ecological Concerns, Aldemaro Romero Jr.

Publications and Research

Scientists who study environmental problems know that the more you work in the field, the more insight you gain into how to solve problems. In other words, the more field experience you have, the deeper your understanding of nature.

One scientist who has had a lot of field experience is Dr. Stephen Gosnell, and his interest in the environment began when he was still a child. “I had interest really early. I grew up in rural South Carolina in a very small town called Landrum. I was outside on a regular basis, playing in the streams and creeks around me ...


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