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The C-Terminal Linker Of Ftsz Acts As An Intrinsically Disordered Peptide During Cell Division In Bacillus Subtilis, Steven Grigsby 2015 Washington University in St Louis

The C-Terminal Linker Of Ftsz Acts As An Intrinsically Disordered Peptide During Cell Division In Bacillus Subtilis, Steven Grigsby

Undergraduate Theses—Unrestricted

The bacterial tubulin homologue FtsZ polymerizes in vitro in a GTP-dependent manner to form long, single stranded filaments. In cells, these filaments assemble at the nascent division site, interacting laterally to form the contractile Z ring. The Z ring serves as a scaffold for the rest of the division machinery and constricts at the leading edge of the invaginating septum during cytokinesis. The FtsZ polypeptide consists of three primary domains: the N-terminal globular core consisting of 315 residues that contains the GTP binding site, a variable and flexible C-terminal linker (CTL) consisting of 50 residues, and a conserved region at ...


Characterization And Fluorescence Of Yellow Biofilms In Karst Caves, Southwest Slovenia, Janez Mulec, Andreea Oarga-Mulec, Rok Tomazin, Tadeja Matos 2015 Karst Research Institute, Research Centre of the Slovenian Academy of Sciences and Arts

Characterization And Fluorescence Of Yellow Biofilms In Karst Caves, Southwest Slovenia, Janez Mulec, Andreea Oarga-Mulec, Rok Tomazin, Tadeja Matos

International Journal of Speleology

Biofilms of different colours that colonize surfaces within karst caves represent a source of nutrients. They occur commonly and abundantly at sites with sediments, and close to seepages or underground rivers. Golden-yellow subaerial biofilms are particularly well observed because of their contrast with their surroundings, the characteristics of the pigment and recently, even more, due to the characteristics of light-emitting diode (LED) illumination. Yellow microbial biofilms were sampled from three caves in southwestern Slovenia, Dimnice, Križna jama and Sveta jama. The highest concentration of cultivable microbes (2.33×108 CFU/g) and the biggest number of identified bacteria (66 ...


Characterization And Investigation Of Fungi Inhabiting The Gastrointestinal Tract Of Healthy And Diseased Humans, Mallory J. Suhr 2015 University of Nebraska-Lincoln

Characterization And Investigation Of Fungi Inhabiting The Gastrointestinal Tract Of Healthy And Diseased Humans, Mallory J. Suhr

Dissertations & Theses in Food Science and Technology

Gastrointestinal microbiome studies have failed to include fungi in total community analyses. As a result, their diversity and function in the gut is poorly understood. Recent work has begun to uncover the role intestinal fungi play in diet, immune system development, interactions with other microorganisms in the gut, and pathogenesis of diseases. Advances in sequencing technologies allow for the ability to profile the fungal gut microbiome (“mycobiome”) in healthy and diseased states. This thesis explores the mycobiome in 1) healthy humans with a vegetarian diet and 2) pediatric small bowel transplant recipients that develop fungal bloodstream infections.

The gut mycobiome ...


Characterization Of Seed Transmission Of Soybean Mosaic Virus In Soybean, Tanvir Bashar 2015 The University of Western Ontario

Characterization Of Seed Transmission Of Soybean Mosaic Virus In Soybean, Tanvir Bashar

University of Western Ontario - Electronic Thesis and Dissertation Repository

Infection by Soybean mosaic virus (SMV) is recognized as a serious, long-standing threat in most soybean (Glyince max (L.)Merr.) producing areas of the world. The aim of this work was to understand how SMV transmits from infected soybean maternal tissues to the next generation by investigating the possible routes and amounts of seed transmission of SMV. Analysis of seeds at various reproductive stages revealed that SMV infects all parts of the seed, including the embryo, cotyledon and testa. In situ hybridization and immunofluorescence studies detected the presence of negative sense RNA and dsRNA in the suspensor base regions and ...


How Does The Exploitation And Degradation Of Finite Natural Resources By Industrial Oil Producers Effect Our Future Planetary Environment?, Zachary J. King Mr. 2015 Kennesaw State University

How Does The Exploitation And Degradation Of Finite Natural Resources By Industrial Oil Producers Effect Our Future Planetary Environment?, Zachary J. King Mr.

Symposium of Student Scholars

Zachary King

Dr. Tu

26 March 2015

GEOG 3700

Abstract

The purpose of this presentation is to communicate content of the reports given by credible institution on the degradation and exploitation of finite natural resources by corporate institutions, for short term financial gain, and how it will effect the future planetary environment. Methods used in obtaining this research range from point source observation directly from oil spills in the Gulf or pipe leaks in the Mid-West, to analytical and numerical data quantifications gathered over a period of two decades. This presentation encompasses a wide scope of information concerning the way ...


The C-Terminal Linker Of Ftsz Acts As An Intrinsically Disordered Peptide During Cell Division In Bacillus Subtilis, Steven Grigsby 2015 Washington University in St Louis

The C-Terminal Linker Of Ftsz Acts As An Intrinsically Disordered Peptide During Cell Division In Bacillus Subtilis, Steven Grigsby

Undergraduate Research Symposium Posters & Abstracts

The bacterial tubulin homologue FtsZ polymerizes in vitro in a GTP-dependent manner to form long, single stranded filaments. In cells, these filaments assemble at the nascent division site, interacting laterally to form the contractile Z-ring, which serves as a scaffold for the rest of the division machinery and constricts at the leading edge of the invaginating septum during cytokinesis. FtsZ consists of three primary domains: the N-terminal globular core consisting of 315 residues that contains the GTP-binding site, a variable and flexible C-terminal linker (CTL) consisting of 50 residues, and a conserved region at the C-terminus consisting of 17 residues ...


Isolation And Comparative Genomic Analysis Of Mycobacteriophage Enkatz, Thomas Van Horn, Micah Rickles-Young, Shaarada Srivasta, Tina Zudock 2015 Washington University in St Louis

Isolation And Comparative Genomic Analysis Of Mycobacteriophage Enkatz, Thomas Van Horn, Micah Rickles-Young, Shaarada Srivasta, Tina Zudock

Thomas Van Horn

Phage Enkatz is a temperate mycobacteriophage isolated from an un-enriched soil sample collected from the South Forty housing area of the Washington University in St. Louis campus. Enkatz displays unequally sized plaques with a clear center that become cloudier with radial distance from the center. Genome analysis indicates that Enkatz is a cluster A1 mycobacteriophage with a genome size of 49,738 bases and 82 identified genes, 33 of which have been assigned functions. This analysis reveals that the majority of the genes in the positive strand code for structural proteins, while the majority of the genes in the negative ...


Analysis Of Activation Of The Nf-Κb Pathway By Shfv Infection, Ashley Aisabor 2015 Georgia State University

Analysis Of Activation Of The Nf-Κb Pathway By Shfv Infection, Ashley Aisabor

Georgia State Undergraduate Research Conference

No abstract provided.


Complex Eukaryotic Protein Expression Using A Prokaryotic Chassis (Escherichia Coli), Derrica Burke, Julia Dave, Jasmine Padalla, Tre Landry 2015 Georgia State University

Complex Eukaryotic Protein Expression Using A Prokaryotic Chassis (Escherichia Coli), Derrica Burke, Julia Dave, Jasmine Padalla, Tre Landry

Georgia State Undergraduate Research Conference

No abstract provided.


Preliminary Report On The Production Of A Shiga-Like Toxoid Fusion Protein As Associated With Novel Flic Vaccine, Michael Maulin 2015 Georgia State University

Preliminary Report On The Production Of A Shiga-Like Toxoid Fusion Protein As Associated With Novel Flic Vaccine, Michael Maulin

Georgia State Undergraduate Research Conference

No abstract provided.


Bone Marrow Stromal Antigen 2 (Bst-2) Dna Is Demethylated In Breast Tumors And Breast Cancer Cells, Wadie D. Mahauad-Fernandez, Nicholas C. Borcherding, Weizhou Zhang, Chioma M. Okeoma 2015 University of Iowa

Bone Marrow Stromal Antigen 2 (Bst-2) Dna Is Demethylated In Breast Tumors And Breast Cancer Cells, Wadie D. Mahauad-Fernandez, Nicholas C. Borcherding, Weizhou Zhang, Chioma M. Okeoma

Department of Microbiology Publications

BACKGROUND: Bone marrow stromal antigen 2 (BST-2) is a known anti-viral gene that has been recently identified to be overexpressed in many cancers, including breast cancer. BST-2 is critical for the invasiveness of breast cancer cells and the formation of metastasis in vivo. Although the regulation of BST-2 in immune cells is unraveling, it is unknown how BST-2 expression is regulated in breast cancer. We hypothesized that meta-analyses of BST-2 gene expression and BST-2 DNA methylation profiles would illuminate mechanisms regulating elevated BST-2 expression in breast tumor tissues and cells.

MATERIALS AND METHODS: We performed comprehensive meta-analyses of BST-2 gene ...


Data From: Human And Murine Clonal Cd8+ T Cell Expansions Arise During Tuberculosis Because Of Tcr Selection, Claudio Nunes-Alves, Matthew G. Booty, Stephen Carpenter, Alissa C. Rothchild, Constance J. Martin, Danielle Desjardins, Katherine Steblenko, Henrik Kloverpris, Rajhmun Madansein, Duran Ramsuran, Alasdair Leslie, Margarida Correia-Neves, Samuel M. Behar 2015 University of Massachusetts Medical School

Data From: Human And Murine Clonal Cd8+ T Cell Expansions Arise During Tuberculosis Because Of Tcr Selection, Claudio Nunes-Alves, Matthew G. Booty, Stephen Carpenter, Alissa C. Rothchild, Constance J. Martin, Danielle Desjardins, Katherine Steblenko, Henrik Kloverpris, Rajhmun Madansein, Duran Ramsuran, Alasdair Leslie, Margarida Correia-Neves, Samuel M. Behar

MaPS Research Data

Manuscript abstract: The immune system can recognize virtually any antigen, yet T cell responses against several pathogens, including Mycobacterium tuberculosis, are restricted to a limited number of immunodominant epitopes. The host factors that affect immunodominance are incompletely understood. Whether immunodominant epitopes elicit protective CD8+ T cell responses or instead act as decoys to subvert immunity and allow pathogens to establish chronic infection is unknown. Here we show that anatomically distinct human granulomas contain clonally expanded CD8+ T cells with overlapping T cell receptor (TCR) repertoires. Similarly, the murine CD8+ T cell response against M. tuberculosis is dominated by TB10.44-11-specific ...


Lessening Malaria Parasite Burden With Yogurt, Alivia M. Shasteen, Sarah W. Lebeis, Nathan Schmidt 2015 University of Tennessee - Knoxville

Lessening Malaria Parasite Burden With Yogurt, Alivia M. Shasteen, Sarah W. Lebeis, Nathan Schmidt

Microbiology Publications and Other Works

The prevalence of malaria across the globe, particularly in countries with minimal health care availability, makes it a top priority for medical researchers. Dr. Nathan Schmidt’s lab discovered that mice from vendors from different geographical locations infected with malaria pathogens yielded significantly different parasite burdens. Researchers discovered that the reason behind the differences in parasite burden was a result of the different compositions of the gut microbiomes of the mice from the different vendors. The research in which I engaged involved manipulating the contents of the gut microbiome through yogurt in the hopes of lessening the parasite burden. Our ...


The Role Of Streptococcus Salivarius As A Modulator Of Homeostasis In The Oral Cavity, Kyle W. MacDonald 2015 The University of Western Ontario

The Role Of Streptococcus Salivarius As A Modulator Of Homeostasis In The Oral Cavity, Kyle W. Macdonald

University of Western Ontario - Electronic Thesis and Dissertation Repository

The oral cavity contains many different surfaces all colonized by prokaryotes, of which over 700 have been identified. While almost all people have some degree of plaque formation, the more concerning diseases of caries, candidiasis and periodontal disease afflict many patients and represent a major public health concern. As these are all diseases which have a component attributable to parts of the microbiota, efforts to manipulate the microbes has until recently involved use of antimicrobial agents. However, due to side effects, resistance and failure to restore homeostasis, this approach is limited. As an alternative, the administration of beneficial microbes (probiotics ...


Cyanobacteria, Algae And Microfungi Present In Biofilm From Božana Cave (Serbia), Slađana Popović, Gordana Subakov Simić, Miloš Stupar, Nikola Unković, Dragana Predojević, Jelena Jovanović, Milica Ljaljević Grbić 2015 University of Belgrade, Faculty of Biology

Cyanobacteria, Algae And Microfungi Present In Biofilm From Božana Cave (Serbia), Slađana Popović, Gordana Subakov Simić, Miloš Stupar, Nikola Unković, Dragana Predojević, Jelena Jovanović, Milica Ljaljević Grbić

International Journal of Speleology

Phototrophic microorganisms (cyanobacteria and algae) and microfungi, were identified from biofilm on the walls of the entrance of BožanaCavein west Serbia. Temperature, relative humidity and light intensity were measured, and chlorophyll a content determined. Light intensity differed from the entrance inwards. However, Chl a content was not proportional to light intensity, instead it was positively correlated to biofilm weight. Biofilm samples from two sites were also observed using a scanning electron microscope. Coccoid forms of cyanobacteria were abundant at the sampling site with the lowest light intensity, while members of the order Nostocales were predominant at the sampling site with ...


The Shellfish Corner--Shellfish Sanitation And The Price Of Shellfish, Michael A. Rice 2015 University of Rhode Island

The Shellfish Corner--Shellfish Sanitation And The Price Of Shellfish, Michael A. Rice

Michael A Rice

Prices of raw molluscan shellfish in different countries around the world are tied to perceived risk of becoming ill if consumed. Wholesale prices of oysters in the southern New England from 1880 to 2010 are analyzed in relation to introduction of flush toilets and sewer systems in the early 20th Century, the initiation of the US National Shellfish Sanitation Program in 1925 and renewed consumer interest in consuming raw shellfish in the latter half of the 20th Century.


Concomitant Uptake Of Antimicrobials And Salmonella In Soil And Into Lettuce Following Wastewater Irrigation, J. Brett Sallach, Yuping Zhang, Laurie Hodges, Daniel D. Snow, Xu Li, Shannon L. Bartelt-Hunt 2015 University of Nebraska--Lincoln

Concomitant Uptake Of Antimicrobials And Salmonella In Soil And Into Lettuce Following Wastewater Irrigation, J. Brett Sallach, Yuping Zhang, Laurie Hodges, Daniel D. Snow, Xu Li, Shannon L. Bartelt-Hunt

Civil Engineering Faculty Publications

The use of wastewater for irrigation may introduce antimicrobials and human pathogens into the food supply through vegetative uptake. The objective of this study was to investigate the uptake of three antimicrobials and Salmonella in two lettuce cultivars. After repeated subirrigation with synthetic wastewater, lettuce leaves and soil were collected at three sequential harvests. The internalization frequency of Salmonella in lettuce was low. A soil horizon-influenced Salmonella concentration gradient was determined with concentrations in bottom soil 2 log CFU/g higher than in top soil. Lincomycin and sulfamethoxazole were recovered from lettuce leaves at concentrations as high as 822 ng ...


Determining The Fate Of Non-O157 Shiga Toxin-Producing Escherichia Coli In Dairy Compost During Storage Using The Optimized Detection Method, Hongye Wang 2015 Clemson University

Determining The Fate Of Non-O157 Shiga Toxin-Producing Escherichia Coli In Dairy Compost During Storage Using The Optimized Detection Method, Hongye Wang

All Theses

Shiga toxin-producing Escherichia coli (STEC), a member of Enterobacteriaceae family, has been recognized as emerging pathogens. Dairy compost is commonly applied to farmland as a soil amendment. Despite the agricultural benefit of manure-based soil amendment, the inadequately treated compost can contribute to fresh produce contamination on the farm. Moreover, the epidemiological results showed that the non-O157 STEC cases have surpassed those of E. coli O157. Therefore, it is critical to evaluate the behavior of non-O157 STEC strains in the dairy manure-based compost. The objectives of this study were to: 1) optimize a culturing method for detecting non-O157 STEC from dairy ...


Characterization Of Biofilms On Medical Device Materials With Application To Reusable Surgical Instruments, Amanda Macaluso 2015 Clemson University

Characterization Of Biofilms On Medical Device Materials With Application To Reusable Surgical Instruments, Amanda Macaluso

All Theses

Reusable medical devices or reprocessed single-use devices are original medical devices that have been used once and then are cleaned, sterilized, and remanufactured for the purpose of an additional single use on a single patient [4]. Improperly reprocessed devices are a significant contributor to hospital-associated infections [4]. Challenges that hinder reprocessing are related to the complexity of reusable medical device design, the necessary validation of cleaning protocols required by the U.S Food and Drug Administration (FDA), the impact of human factors throughout the reprocessing cycle, as well as economic factors within new business models that are centered on reprocessing ...


The Effects Of Probiotics Supplementation On Health Using Caenorhabditis Elegans As A Model System, Miranda Klees 2015 Clemson University

The Effects Of Probiotics Supplementation On Health Using Caenorhabditis Elegans As A Model System, Miranda Klees

All Theses

The 'Western Diet,' prominent among developed nations, often refers to a diet rich in meat proteins and refined sugars. Western society may in part be plagued with obesity and obesity related diseases due to a diet enriched with glucose. With an increasing glycemic index observed in Western society, it comes to no surprise that obesity, diabetes, heart disease, and other obesity related diseases are on the rise. The Centers for Disease Control and Prevention describes obesity as an epidemic, affecting more than 35% of U.S. citizens. Shortened lifespan and increased susceptibility to pathogens are associated with these diseases and ...


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