Open Access. Powered by Scholars. Published by Universities.®

Pharmacology, Toxicology and Environmental Health Commons

Open Access. Powered by Scholars. Published by Universities.®

2,343 Full-Text Articles 3,969 Authors 308,135 Downloads 132 Institutions

All Articles in Pharmacology, Toxicology and Environmental Health

Faceted Search

2,343 full-text articles. Page 1 of 70.

Environmental Res. Bernard Singleton 2016 .Pdf, Joy Semien 2016 Texas Southern University

Environmental Res. Bernard Singleton 2016 .Pdf, Joy Semien

Joy Semien

The Deepwater Horizon (DWH) oil spill in the Gulf of Mexico was the largest maritime oil spill in history
resulting in the accumulation of genotoxic substances in the air, soil, and water. This has potential far-
reaching health impacts on cleanup field workers and on the populations living in the contaminated
coastal areas. We have employed portable airborne particulate matter samplers (SKC Biosampler Im-
pinger) and a genetically engineered bacterial reporter system (umu-ChromoTest from EBPI) to de-
termine levels of genotoxicity of air samples collected from highly contaminated areas of coastal
Louisiana including Grand Isle, Port Fourchon, and Elmer's ...


Ex Vivo Immune Responses In Freshwater Fish Leucocytes Exposed To Environmental Serotypes Of Lipopolysaccharides, Hakim SAMAI 2016 Université Reims Champagne-Ardenne, UMR-I 02 SEBIO

Ex Vivo Immune Responses In Freshwater Fish Leucocytes Exposed To Environmental Serotypes Of Lipopolysaccharides, Hakim Samai

2nd International Conference of Fish & Shellfish Immunology

No abstract provided.


Investigations Of The Effects Of Different Ventilation Structures On Physiologically Based Pharmacokinetic Modeling (Pbpk) Simulations, Karen A. Yokley 2016 Elon University

Investigations Of The Effects Of Different Ventilation Structures On Physiologically Based Pharmacokinetic Modeling (Pbpk) Simulations, Karen A. Yokley

Biology and Medicine Through Mathematics Conference

No abstract provided.


Plastic Pollution And The Global Throwaway Culture: Environmental Injustices Of Single-Use Plastic, Kristin L. McDermott 2016 Salve Regina University

Plastic Pollution And The Global Throwaway Culture: Environmental Injustices Of Single-Use Plastic, Kristin L. Mcdermott

ENV 434 Environmental Justice

The global throwaway culture has created a cross-ecosystem plastic pollution injustice. The first to suffer this injustice will be the most vulnerable. Our oceans have become our dumpsters. The throwaway culture has created a disrespect of material goods that has turned the earth’s resources into rubbish after a single use. Eighty percent of the yearly 8 million tons of plastic that enter the ocean is single use plastic, such as plastic bottles, plastic shopping bags, or cigarette lighters.[1] Plastic has destroyed ecosystems, robbing impoverished communities of natural resources and of a healthy and safe living environment. First to ...


Implementing A Team-Based Learning Pedagogy In An Integrated Medicinal Chemistry And Pharmacology Course, Denise S. Simpson, Rebecca J. Gryka 2016 Cedarville University

Implementing A Team-Based Learning Pedagogy In An Integrated Medicinal Chemistry And Pharmacology Course, Denise S. Simpson, Rebecca J. Gryka

Rebecca J. Gryka, R.Ph., Pharm.D., Ph.D.

No abstract provided.


Effect Of Bisphenol-A On Neurodevelopment In Drosophila Melanogaster Larvae, Alexandra M. Streifel 2016 College of Saint Benedict/Saint John's University

Effect Of Bisphenol-A On Neurodevelopment In Drosophila Melanogaster Larvae, Alexandra M. Streifel

All College Thesis Program

This paper examines the effects of the chemical preservative bisphenol-A on the developing nervous systems of Drosophila melanogaster, or fruit fly, larvae. This study examines the effects of bisphenol-A using both behavioral as well as morphological paradigms. It was determined that bisphenol-A significantly increased the amount of time larvae spent in seeking behavior, the number of peristaltic contractions, and the distance traveled in a linear fashion. In the morphological analysis, indications of increased dendritic area in experimental larvae existed, but there was not enough data to determine significance. For future research, it is recommended that more data be gathered to ...


Ecological Risks Of The Conventional Insecticide/Fungicide Seed Treatment Mixture Of Thiamethoxam And Mefenoxam In Soybean On Beneficial Insects, Carolina Camargo 2016 University of Nebraska-Lincoln

Ecological Risks Of The Conventional Insecticide/Fungicide Seed Treatment Mixture Of Thiamethoxam And Mefenoxam In Soybean On Beneficial Insects, Carolina Camargo

Dissertations and Student Research in Entomology

The impact of neonicotinoid seed treatments on beneficial insects has been a controversial topic during the last years. While neonicotinoids are usually used as mixtures with systemic fungicides, few studies have examined the impact of the mixtures on beneficial insects. Pesticide mixtures can have synergistic, additive, or antagonistic effects on the toxicity of neonicotinoids on non-target species.

Thiamethoxam with mefenoxam is the most used neonicotinoid insecticide/fungicide mixture applied to soybean. Based on the systemic nature of thiamethoxam and mefenoxam, residues of this insecticide/fungicide mixture can be present in soybean vegetative and floral tissue with potential impacts to beneficial ...


Implementing A Community-Based Social Marketing Project To Improve Agricultural Worker Health, Joan D. Flocks, Leslie Clarke, Stan Albrecht, Carol Bryant, Paul Monaghan, Holly Baker 2016 University of Florida Levin College of Law

Implementing A Community-Based Social Marketing Project To Improve Agricultural Worker Health, Joan D. Flocks, Leslie Clarke, Stan Albrecht, Carol Bryant, Paul Monaghan, Holly Baker

Joan D. Flocks

The Together for Agricultural Safety project is a community-based social marketing project working to reduce the adverse health effects of pesticide exposure among fernery and nursery workers in Florida. In 3 years, the collaboration between university and community researchers has embodied many of the principles of community-based research while completing multiple stages of formative data collection required for a social marketing project. This hybrid approach to developing a health intervention for a minority community has been successful in its early stages because the community partners are organized, empowered, and motivated to execute research activities with the assistance of academic partners ...


Pesticide Policy And Farmworker Health, Joan D. Flocks 2016 University of Florida Levin College of Law

Pesticide Policy And Farmworker Health, Joan D. Flocks

Joan D. Flocks

Although data on the carcinogenicity of agricultural pesticides are still being generated and are thus incomplete, research such as the Agricultural Health Study indicates that populations with increased, regular exposure to pesticides have high rates of a variety of cancers (National Institutes of Health & Environmental Protection Agency 2008). Policies that regulate toxins such as pesticides are envisioned by the public to be empirical and objective, but toxins are socially produced and their regulation is just as often based on political and economic factors as it is on science (Luke 2000). This does not bode well for farm- workers who are ...


Influence Of Water Hardness On Accumulation And Effects Of Silver In The Green Alga, Raphidocelis Subcapitata, Aarya Venkat, Adriana L. Amerson, Gretchen K. Bielmyer-Fraser 2016 Valdosta State University

Influence Of Water Hardness On Accumulation And Effects Of Silver In The Green Alga, Raphidocelis Subcapitata, Aarya Venkat, Adriana L. Amerson, Gretchen K. Bielmyer-Fraser

Georgia Journal of Science

Metal pollution from anthropogenic sources can pose a threat to aquatic systems. Silver is released into the environment from various industrial processes. In excess, silver can accumulate and cause adverse effects in aquatic organisms, particularly those in lower trophic levels, such as phytoplankton. Water chemistry parameters, such as hardness, have been shown to modify toxicity of metals because divalent cations compete with the metal for binding sites on the biological membrane. The objective of this study was to assess population growth and silver accumulation in the green alga, Raphidocelis subcapitata, after silver exposure in waters of varying hardness for 7 ...


Evaluating The Cytotoxic Effects Of Cellulose Nanocrystals (Cncs) Using Autobioluminescent Yeast And Human Cells, Julianna Hughes Burchett 2016 University of Tennessee, Knoxville

Evaluating The Cytotoxic Effects Of Cellulose Nanocrystals (Cncs) Using Autobioluminescent Yeast And Human Cells, Julianna Hughes Burchett

EURēCA: Exhibition of Undergraduate Research and Creative Achievement

Cellulose nanocrystals (CNCs) are widely used in different industries including pharmaceutical and cosmetic production due to their adept physical and biological properties. Because CNCs are becoming a more prevalent material and have a high potential of being redistributed in the environment, it is important to understand their toxic potentials in biological systems, including organisms of various trophic levels. This study evaluated the cytotoxic effects of CNCs in the lower eukaryotic organism Saccharomyces cerevisiae and human embryonic kidney (HEK293) cells using autobioluminescent yeast and human cell reporters, respectively. The S. cerevisiae and HEK293 reporter cells were engineered to express a synthetic ...


Inquiry Into The Implementation Of Bush’S Executive Order 13211 And The Impact On Environmental And Public Health Regulation, Elizabeth Ann Glass Geltman, Gunwant Gill, Miriam Jovanovic 2016 CUNY School of Public Health

Inquiry Into The Implementation Of Bush’S Executive Order 13211 And The Impact On Environmental And Public Health Regulation, Elizabeth Ann Glass Geltman, Gunwant Gill, Miriam Jovanovic

Publications and Research

Executive Order 13211, promulgated in 2001, requires the federal government to consider the impact of federal action on energy independence as part of the George W. Bush’s National Energy Policy. This law review examines whether EO 13211 was used to curtail environmental protection and natural resource conservation. The article begins with a review of the procedure required of federal agencies under EO 13211 and its associated documents. The paper then examines case law and published federal rulemaking proceedings and examines how federal agencies apply tests to evaluate the potential energy effect. The study concludes that EO 13211 strikes a ...


Phytoremediation Of Herbicide-Contaminated Surface Water With Aquatic Plants, Pamela Rice, Todd Anderson, Joel Coats 2016 Iowa State University

Phytoremediation Of Herbicide-Contaminated Surface Water With Aquatic Plants, Pamela Rice, Todd Anderson, Joel Coats

Joel R. Coats

There is current interest in the use of artificial wetlands and macrophyte-cultured ponds for the treatment of agricultural drainage water, sewage, and industrial effluents. Aquatic plant-based water treatment systems have proved effective and economical in improving the quality of wastewaters containing excess nutrients, organic pollutants, and heavy metals. This investigation was conducted to test the hypothesis that herbicide-tolerant aquatic plants can remediate herbicide-contaminated waters. The addition of Ceratophyllum demersum (coontail, hornwort), Elodea canadensis (American elodea, Canadian pondweed), or Lemna minor(common duckweed) significantly (p < 0.01) reduced the concentration of [14C]metolachlor (MET) remaining in the treated water. After a 16-day incubation period, only 1.44%, 4.06%, and 22.7% of the applied [14C]MET remained in the water of the surface water systems containing C. demersum, E. canadensis, or L. minor whereas 61% of the applied [14C]MET persisted in ...


The Debate On The Health Effects Attributable To Low Radiation Exposure, Abel J. Gonzalez 2016 International Atomic Energy Agency (IAEA), Vienna, Austria

The Debate On The Health Effects Attributable To Low Radiation Exposure, Abel J. Gonzalez

University of New Hampshire Law Review

[Excerpt] "Few scientific issues have aroused passions more than the dispute about the health effects attributable to low levels of exposure to ionizing radiation (or radiation in short) and the currently authoritative dose response hypothesis, termed “linear non-threshold,” or LNT. Finding out whether health effects are induced by low-level radiation exposures, and if so, what they are, has become a kind of contest rather than a serious scientific inquiry. Sometimes it seems that rationality, or a methodical examination of the unknown, has disappeared from this debate. While the confrontation of different hypotheses is typical in academic discussions – at least until ...


Effects Of The Shape Of The Radiation Dose-Response Curve On Public Acceptance Of Radiation And Nuclear Energy, Audeen W. Fentiman 2016 Ohio State University

Effects Of The Shape Of The Radiation Dose-Response Curve On Public Acceptance Of Radiation And Nuclear Energy, Audeen W. Fentiman

University of New Hampshire Law Review

[Excerpt] "INTRODUCTION The public generally accepts the premise that exposure to radiation can have an undesirable effect. Furthermore, it believes that as the radiation dose increases, the magnitude of the effect will increase. On the other hand, while the background radiation dose varies from a few hundred millirem/ year (a few millisieverts/yr) in some places to a few thousand millirem/ yr (tens of millisieverts/yr) in others, researchers have been unable to find a correlation between the level of background radiation and incidence of cancer or other maladies attributable to radiation. No one is sure of the exact relationship ...


Historical Development Of The Linear Nonthreshold Dose- Response Model As Applied To Radiation, Ronald L. Kathren 2016 Washington State University; United States Transuranium and Uranium Registries (retired)

Historical Development Of The Linear Nonthreshold Dose- Response Model As Applied To Radiation, Ronald L. Kathren

University of New Hampshire Law Review

[Excerpt] "INTRODUCTION Despite the nearly universal adoption of the linear nonthreshold dose response model (LNT) as the primary basis for radiation protection standards for the past half century, the LNT remains highly controversial and a contentious topic of discussion among health physicists, radiation biologists, and other radiological scientists. Indeed, it has been pointed out that the LNT has assumed the status of a paradigm, synonymous with an ideal, standard, or paragon or perhaps to some, a sacred cow.1 Reduced to its very basics, the LNT postulates that every increment of ionizing radiation dose, however small, carries with it a ...


Introduction To Special Issue On Radiation Effects, P. Andrew Karam 2016 University of Rochester

Introduction To Special Issue On Radiation Effects, P. Andrew Karam

University of New Hampshire Law Review

[Excerpt] "How dangerous is radiation? How much radiation does it take to give us cancer? Are we wasting money on overly restrictive regulations, or are we not being sufficiently protective of our radiation workers and the public? How much clean-up is necessary on our Department of Energy facilities? What about Yucca Mountain and nuclear reactor plants – can they be made safe? These are only a few of the questions that have been asked, and will continue to be asked, about radiation. Unfortunately, these all come down, in part or in whole, to the question “What is the shape of the ...


The Impact Of Sertraline Co-Administration On The Pharmacokinetics Of Olanzapine: A Population Pharmacokinetic Analysis Of The Stop-Pd, Simon Davies, Benoit Mulsant, Alastair Flint, Barnett Meyers, Anthony Rothschild, Ellen Whyte, Margaret Kirshner, Denise Sorisio, Bruce Pollock, Robert Bies 2016 Centre for Addiction and Mental Health

The Impact Of Sertraline Co-Administration On The Pharmacokinetics Of Olanzapine: A Population Pharmacokinetic Analysis Of The Stop-Pd, Simon Davies, Benoit Mulsant, Alastair Flint, Barnett Meyers, Anthony Rothschild, Ellen Whyte, Margaret Kirshner, Denise Sorisio, Bruce Pollock, Robert Bies

Anthony J. Rothschild

BACKGROUND AND OBJECTIVE: Clinical evidence and expert opinion support using a combination of an antipsychotic and an antidepressant when treating major depression with psychotic features. We characterized the impact of sertraline co-administration on olanzapine clearance in psychotic depression using population pharmacokinetic methods.

METHODS: The Study of Pharmacotherapy for Psychotic Depression (STOP-PD) randomized 259 participants to olanzapine plus placebo or olanzapine plus sertraline. Olanzapine was started at 2.5-5 mg/day and sertraline at 25-50 mg/day. Doses were increased to a maximum of 20 mg/day for olanzapine and 200 mg/day for sertraline. Up to four olanzapine concentration samples ...


Xenoestrogens From Household Plastics Bind Estrogen Receptors And Affect Cell Proliferation, Susan G. Hurley, Brett R. Lackey, Patricia L. Tate, Sandra L. Gray 2016 Clemson University

Xenoestrogens From Household Plastics Bind Estrogen Receptors And Affect Cell Proliferation, Susan G. Hurley, Brett R. Lackey, Patricia L. Tate, Sandra L. Gray

Journal of the South Carolina Academy of Science

Xenoestrogens are “foreign” chemicals or compounds that interact with estrogen receptors as either agonists or antagonists to interfere with endocrine system function. Xenoestrogens include phytoestrogens, pesticides, industrial by- products and synthetic estrogens. In this study, consumer plasticware, including baby bottles and food storage containers, were found to release xenoestrogenic compounds that bound to ERα and ERβ and affected cell proliferation.


Thromboxane A2 And Tp Receptors: A Trail Of Research, Well Traveled, Perry V. Halushka PhD, MD 2016 Medical University of South Carolina

Thromboxane A2 And Tp Receptors: A Trail Of Research, Well Traveled, Perry V. Halushka Phd, Md

Journal of the South Carolina Academy of Science

This article was written is response to a request from the editor-in-chief as a result of my receiving the Governor’s Award in Scientific Awareness. My goal is to provide a glimpse into a 40 plus year research career that was predominately focused on the role of thromboxane A2 and its receptor (TP) in physiologic and pathophysiologic processes in the cardiovascular system. It also enumerates the lessons learned along the way that may lead to a productive research career. Those lessons were; Perseverance, Think out of the box, Challenge the dogma, Take risks, Failure is not a bad thing ...


Digital Commons powered by bepress