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Pharmacology, Toxicology and Environmental Health Commons

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Expression Of Hepatic Cytochrome P450 Drug Metabolizing Enzymes In Diabetes And Diabetic Nephropathy, Cheng Jay Fang 2018 The University of Western Ontario

Expression Of Hepatic Cytochrome P450 Drug Metabolizing Enzymes In Diabetes And Diabetic Nephropathy, Cheng Jay Fang

Electronic Thesis and Dissertation Repository

The prevalence of diabetes worldwide is rapidly increasing. Polypharmacy, along with a high risk of adverse drug reactions, is common in diabetic patients. Cytochrome P450 (CYP) 3A and 2C drug metabolizing enzymes are reduced in chronic kidney disease (CKD), altering drug pharmacokinetics and contributing to adverse drug reactions. A large fraction of commonly prescribed drugs are metabolized by CYP3A and CYP2C. Approximately 40% of all CKD cases are attributed to diabetic nephropathy (DN) and early DN presents as mild kidney disease. This study aims to evaluate the impact of diabetes and DN on levels and activity of hepatic CYP3A and ...


Profile Interview With Norman E. Fenn, Shannon L. Castek 2018 Purdue University

Profile Interview With Norman E. Fenn, Shannon L. Castek

Purdue Journal of Service-Learning and International Engagement

Shannon L. Castek is a fourth-generation Boilermaker and fourth-professional-year student in the Purdue University College of Pharmacy. Throughout her time in pharmacy school, Shannon has enjoyed supplementing her curricular work with service-learning activities, participating in health screenings and immunization events with the Purdue chapter of the American Pharmacists Association–Academy of Student Pharmacists. She plans to pursue a pharmacy residency following graduation to achieve her dream of becoming an ambulatory care pharmacist. In this article, Shannon highlights the service-learning endeavors of Dr. Norman Fenn in the College of Pharmacy.


The Pharmaceutical Industry: A Pharmacy Student's Guide, Christian Egly, Yaman Kaakeh 2018 Purdue University

The Pharmaceutical Industry: A Pharmacy Student's Guide, Christian Egly, Yaman Kaakeh

Purdue Journal of Service-Learning and International Engagement

Christian Egly is a fourth-year (P4) pharmacy student in the Purdue University College of Pharmacy. During his years at Purdue, he worked in labs performing bench research in clinical pharmacology and biochemistry. He plans to work in the pharmaceutical industry after graduation. During his fourth year, he completed rotations in business development at Kashiv Pharma, LLC, and was hired there for an internship in 2017. In the article, Christian describes his personal experiences at Kashiv Pharma, LLC, and how industry can positively affect patient communities.


Pyronaridine Exerts Potent Cytotoxicity On Human Breast And Hematological Cancer Cells Through Induction Of Apoptosis, Alberto Martinez, Paulina J. Villanueva, Sarah T. Baca, Rebecca E. DeJesus, Manuel Larragoity, Lisett Contreras, Denisse A. Gutierrez, Armando Varela-Ramirez, Renato J. Aguilera 2018 NYC College of Technology

Pyronaridine Exerts Potent Cytotoxicity On Human Breast And Hematological Cancer Cells Through Induction Of Apoptosis, Alberto Martinez, Paulina J. Villanueva, Sarah T. Baca, Rebecca E. Dejesus, Manuel Larragoity, Lisett Contreras, Denisse A. Gutierrez, Armando Varela-Ramirez, Renato J. Aguilera

Publications and Research

The potent antimalarial drug pyronaridine (PND) was tested for its potential as an anticancer drug. After exposing cancerous (17) and non-cancerous (2) cells to PND for 72 hr, PND was found to exhibit consistent and potent cytotoxic activity at low micromolar (μM) concentrations that ranged from 1.6 μM to 9.4 μM. Moreover, PND exerted a significant selective cytotoxicity index (SCI) on five out of seven breast cancer cell lines tested, with favorable values of 2.5 to 4.4, as compared with the non-cancerous breast MCF-10A cell line. By using the same comparison, PND exhibited a significant SCI ...


Assesing Port Reception Facilities For Ship Generated Solid Waste: The Case Of The Port Of Walvis Bay, Namibia., Shapua Randy Mandela Kalomo 2018 World Maritime University

Assesing Port Reception Facilities For Ship Generated Solid Waste: The Case Of The Port Of Walvis Bay, Namibia., Shapua Randy Mandela Kalomo

World Maritime University Dissertations

No abstract provided.


Resilience Of The Nigerian Coastal Socio-Ecological System: Case Study Of The Niger Delta Region, Chinenye Joy Ijiomah 2018 World Maritime University

Resilience Of The Nigerian Coastal Socio-Ecological System: Case Study Of The Niger Delta Region, Chinenye Joy Ijiomah

World Maritime University Dissertations

No abstract provided.


45 - The Sublethal Effects And Bioaccumulation Of 17a-Ethinyl Estradiol In Lumbriculus Variegatus, Kikelomo Ogunsemore 2018 Augusta University

45 - The Sublethal Effects And Bioaccumulation Of 17a-Ethinyl Estradiol In Lumbriculus Variegatus, Kikelomo Ogunsemore

Georgia Undergraduate Research Conference (GURC)

The threat of freshwater scarcity is a global concern. With less than 1% of Earth’s total water available for human consumption, there has been concern about toxic contaminants affecting available freshwater sources.

Freshwater sources are subject to contamination from toxic compounds and other harmful materials through improper sewage cleanup and pollution. Ethinyl estradiol, a synthetic, steroidal estrogen used in contraception, is present in varying concentrations across freshwater sources worldwide. Ethinyl estradiol (EE) is also classified as an endocrine disruptor that is known to interfere with the endocrine system. Endocrine disruptors can create adverse effects on bodily systems and have ...


Optimization Of Time-Weighted Average Air Sampling By Solid-Phase Microextraction Fibers Using Finite Element Analysis Software, Bulat Kenessov, Jacek A. Koziel, Nassiba Baimatova, Olga P. Demyanenko, Miras Derbissalin 2018 Al-Farabi Kazakh National University

Optimization Of Time-Weighted Average Air Sampling By Solid-Phase Microextraction Fibers Using Finite Element Analysis Software, Bulat Kenessov, Jacek A. Koziel, Nassiba Baimatova, Olga P. Demyanenko, Miras Derbissalin

Agricultural and Biosystems Engineering Publications

Determination of time-weighted average (TWA) concentrations of volatile organic compounds (VOCs) in air using solid-phase microextraction (SPME) is advantageous over other sampling techniques, but is often characterized by insufficient accuracies, particularly at longer sampling times. Experimental investigation of this issue and disclosing the origin of the problem is problematic and often not practically feasible due to high uncertainties. This research is aimed at developing the model of the TWA extraction process and optimization of TWA air sampling by SPME using finite element analysis software (COMSOL Multiphysics, Burlington, MA, USA). It was established that sampling by porous SPME coatings with high ...


Neurobehavioral Evaluation Of Mice Dosed With Water Hemlock Green Seeds And Tubers, Camila F. P. Orlando-Goulart, Kevin D. Welch, James A. Pfister, Daniel S. Goulart, Adilson D. Damasceno, Stephen T. Lee 2018 Federal University of Goiás

Neurobehavioral Evaluation Of Mice Dosed With Water Hemlock Green Seeds And Tubers, Camila F. P. Orlando-Goulart, Kevin D. Welch, James A. Pfister, Daniel S. Goulart, Adilson D. Damasceno, Stephen T. Lee

Poisonous Plant Research (PPR)

Water hemlock are plants of the genus Cicuta and are toxic to animals and humans. The primary toxin is cicutoxin, which is abundant in the tubers, but less abundant in other parts of the plant. Other cicutoxin-like compounds, such as cicutols, which may also contribute to the toxicity of water hemlock, are more abundant in non-tuber plant parts. The objective of this study was to determine the toxicity of different parts of water hemlock and characterize their effects on motor function/coordination in mice. An aqueous extract of green seeds, dry seeds, tubers, flowers and stems of water hemlock was ...


Politically Unhealthy: Flint’S Fight Against Poverty, Environmental Racism, And Dirty Water, Tomeka M. Robinson, Garrett Shum, Sabrina Singh 2018 Hofstra University

Politically Unhealthy: Flint’S Fight Against Poverty, Environmental Racism, And Dirty Water, Tomeka M. Robinson, Garrett Shum, Sabrina Singh

Journal of International Crisis and Risk Communication Research

The social force of race in relation to natural resources plays a prominent role in which communities are disproportionately affected by pollution. Scholars have described how people of color are disproportionately victims of environmental discrimination and disparities because they lack the necessary social capital to bring attention to their plight, as demonstrated by the case of the Flint, Michigan, Water Crisis. In this article, we use a critical race theory lens to explore how the Flint Water Crisis constitutes a case study of environmental racism. More specifically, we discuss the public health implications of environmental racism on the residents of ...


T Cell Epitope Engineering: An Avian H7n9 Influenza Vaccine Strategy For Pandemic Preparedness And Response, Leonard Moise, Bethany M. Biron, Christine M. Boyle, Nese Kurt Yilmaz, Hyesun Jang, Celia A. Schiffer, Ted M. Ross, William D. Martin, Anne S. De Groot 2018 University of Rhode Island

T Cell Epitope Engineering: An Avian H7n9 Influenza Vaccine Strategy For Pandemic Preparedness And Response, Leonard Moise, Bethany M. Biron, Christine M. Boyle, Nese Kurt Yilmaz, Hyesun Jang, Celia A. Schiffer, Ted M. Ross, William D. Martin, Anne S. De Groot

Schiffer Lab Publications

The delayed availability of vaccine during the 2009 H1N1 influenza pandemic created a sense of urgency to better prepare for the next influenza pandemic. Advancements in manufacturing technology, speed and capacity have been achieved but vaccine effectiveness remains a significant challenge. Here, we describe a novel vaccine design strategy called immune engineering in the context of H7N9 influenza vaccine development. The approach combines immunoinformatic and structure modeling methods to promote protective antibody responses against H7N9 hemagglutinin (HA) by engineering whole antigens to carry seasonal influenza HA memory CD4(+) T cell epitopes - without perturbing native antigen structure - by galvanizing HA-specific memory ...


It's About Communities: The Commitment To Promoting A Culturally Competent Environmental Health Workforce., Clint Pinion Jr., Leslie D. Mitchell, Jason W. Marion 2018 Eastern Kentucky University

It's About Communities: The Commitment To Promoting A Culturally Competent Environmental Health Workforce., Clint Pinion Jr., Leslie D. Mitchell, Jason W. Marion

EKU Faculty and Staff Scholarship

Environmental health and public health are profoundly local. The Association of Environmental Health Academic Programs (AEHAP) firmly agrees and for this reason, it is important to have local environmental health experts who know the pulse of their communities. AEHAP believes in supporting the advanced scientific education of environmental health in these communities through people from these communities. Accordingly, AEHAP has sought to promote and support accredited environmental health programs among a diverse cross-section of the U.S. higher education landscape. AEHAP’s students are diverse in many ways, including socioeconomically, racially, ethnically, and culturally. The value of this approach enhances ...


Macrophages But Not Astrocytes Harbor Hiv Dna In The Brains Of Hiv-1-Infected Aviremic Individuals On Suppressive Antiretroviral Therapy, Allen Ko, Guobin Kang, Julian B. Hattler, Hadiza I. Galadima, Junfeng Zhang, Qingsheng Li, Woong-Ki Kim 2018 Old Dominion University

Macrophages But Not Astrocytes Harbor Hiv Dna In The Brains Of Hiv-1-Infected Aviremic Individuals On Suppressive Antiretroviral Therapy, Allen Ko, Guobin Kang, Julian B. Hattler, Hadiza I. Galadima, Junfeng Zhang, Qingsheng Li, Woong-Ki Kim

Community & Environmental Health Faculty Publications

The question of whether the human brain is an anatomical site of persistent HIV-1 infection during suppressive antiretroviral therapy (ART) is critical, but remains unanswered. The presence of virus in the brains of HIV patients whose viral load is effectively suppressed would demonstrate not only the potential for CNS to act as an anatomical HIV reservoir, but also the urgent need to understand the factors contributing to persistent HIV behind the blood-brain barrier. Here, we investigated for the first time the presence of cells harboring HIV DNA and RNA in the brains from subjects with undetectable plasma viral load and ...


Effect Of Arsenic Exposure On Early Eye Development In Zebrafish (Danio Rerio), Remy S. Babich 2018 University of Maine

Effect Of Arsenic Exposure On Early Eye Development In Zebrafish (Danio Rerio), Remy S. Babich

Electronic Theses and Dissertations

Arsenic is a metalloid that contaminates drinking water supplies worldwide. Due to concerns for human health, the World Health Organization (WHO) and the U.S. Environmental Protection Agency (EPA) have established a safe level in drinking water of ≤ 10 ppb. Arsenic has been shown to have carcinogenic effects in humans at high and low doses. Chronic exposure may result in dermal conditions such as hyperkeratosis and hyperpigmentation. Recently, arsenic exposure has also been linked to lower IQ values in children. The effect of arsenic on neurogenesis, specifically eye development, has not been widely explored. This study aimed to examine the ...


A Review Of Inhalation Exposure To Mold And Adverse Health Outcomes, Amanda S. Persad, Todd Stedeford, Marek Banasik, Tomasz T. Suchecki, Carlos A. Muro-Cacho 2018 Florida State University College of Law

A Review Of Inhalation Exposure To Mold And Adverse Health Outcomes, Amanda S. Persad, Todd Stedeford, Marek Banasik, Tomasz T. Suchecki, Carlos A. Muro-Cacho

Florida State University Journal of Land Use and Environmental Law

No abstract provided.


Mycotoxins: Mechanisms For Toxicity And Methods For Identifying Exposed Individuals, Carlos A. Muro-Cach, Todd Stedeford, Marek Banasik, Tomasz T. Suchecki, Amanda S. Persad 2018 Florida State University College of Law

Mycotoxins: Mechanisms For Toxicity And Methods For Identifying Exposed Individuals, Carlos A. Muro-Cach, Todd Stedeford, Marek Banasik, Tomasz T. Suchecki, Amanda S. Persad

Florida State University Journal of Land Use and Environmental Law

No abstract provided.


Toxicology And Risk Assessment Of Mycotoxins, Raymond D. Harbison, Todd Stedeford, Marek Banasik, Carlos A. Muro-Cacho 2018 Florida State University College of Law

Toxicology And Risk Assessment Of Mycotoxins, Raymond D. Harbison, Todd Stedeford, Marek Banasik, Carlos A. Muro-Cacho

Florida State University Journal of Land Use and Environmental Law

No abstract provided.


Yardwork: A Biography Of An Urban Place By Daniel Coleman, Vivian M. Hansen 2018 University of Calgary

Yardwork: A Biography Of An Urban Place By Daniel Coleman, Vivian M. Hansen

The Goose

Review of Daniel Coleman's Yardwork: A Biography of an Urban Place.


The Right To Be Cold: One Woman’S Fight To Protect The Arctic And Save The Planet From Climate Change By Sheila Watt-Cloutier, Leah Van Dyk 2018 University of Calgary

The Right To Be Cold: One Woman’S Fight To Protect The Arctic And Save The Planet From Climate Change By Sheila Watt-Cloutier, Leah Van Dyk

The Goose

Review of Sheila Watt-Cloutier's The Right to Be Cold: One Woman's Fight to Protect the Arctic and Save the Planet from Climate Change.


Hiv Integrase Inhibitor Pharmacogenetics And Clinical Outcomes: An Exploratory Association Study, Derek E. Murrell 2018 East Tennessee State University

Hiv Integrase Inhibitor Pharmacogenetics And Clinical Outcomes: An Exploratory Association Study, Derek E. Murrell

Electronic Theses and Dissertations

As HIV is now primarily a chronic condition, treatment is given life-long with changes as necessitated by alterations in tolerability and efficacy. Thus, personalized medicine may be useful in the prevention of unnecessary drug exposure and avoidable side effects. Three of the four currently available HIV integrase strand transfer inhibitors (INSTIs), raltegravir, elvitegravir, and dolutegravir, are widely utilized antiretrovirals in the USA and exhibit variations in outcomes among subjects. To interrogate differences among subjects receiving these drugs, we investigated the association of several single nucleotide polymorphisms (SNPs) with drug exposure, clinical outcomes, and subject-reported adverse events. HIV+ adults (≥18 years ...


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