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Submonomer Synthesis And Structure-Activity Relationship Studies Of Azapeptide Inhibitors Of The Insulin Receptor Tyrosine Kinase, Lathamol A. Kurian 2014 Seton Hall University

Submonomer Synthesis And Structure-Activity Relationship Studies Of Azapeptide Inhibitors Of The Insulin Receptor Tyrosine Kinase, Lathamol A. Kurian

Seton Hall University Dissertations and Theses (ETDs)

Azapeptides are a class of peptide mimics (peptidomimetics), which have served as valuable tools for the development of peptide based therapeutic agents. The therapeutic promise of azapeptides has been correlated to its primary sequence modification which translates into bio-active secondary structures that improves the pharmacological properties of the native peptide sequence. More specifically, azapeptides contain a semicarbazide within the peptide backbone which restricts the peptide bond torsion angles (φ, ψ) into pre-organized b-turn secondary structures. Thus, azapeptides have been shown to stabilize bio-active b-turn secondary structures responsible for high affinity and selective binding to a target receptor or ...


Light Pollution Research Through Citizen Science, John Kanemoto 2014 California Polytechnic State University

Light Pollution Research Through Citizen Science, John Kanemoto

STEM Teacher and Researcher (STAR) Program Posters

Light pollution (LP) can disrupt and/or degrade the health of all living things, as well as, their environments. The goal of my research at the NOAO was to check the accuracy of the citizen science LP reporting systems entitled: Globe at Night (GaN), Dark Sky Meter (DSM), and Loss of the Night (LoN). On the GaN webpage, the darkness of the night sky (DotNS) is reported by selecting a magnitude chart. Each magnitude chart has a different density/number of stars around a specific constellation. The greater number of stars implies a darker night sky. Within the DSM iPhone ...


Associations Between Prenatal Exposure To Air Pollution, Small For Gestational Age, And Term Low Birthweight In A State-Wide Birth Cohort, Lisa C. Vinikoor-Imler, J. Allen Davis, Robert E. Meyer, Lynne Messer, Thomas J. Luben 2014 Portland State University

Associations Between Prenatal Exposure To Air Pollution, Small For Gestational Age, And Term Low Birthweight In A State-Wide Birth Cohort, Lisa C. Vinikoor-Imler, J. Allen Davis, Robert E. Meyer, Lynne Messer, Thomas J. Luben

Community Health Faculty Publications and Presentations

A range of health effects, including adverse pregnancy outcomes, have been associated with exposure to ambient concentrations of particulate matter (PM) and ozone (O3). The objective of this study was to determine whether maternal exposure to fine particulate matter (PM2.5) and O3 during pregnancy is associated with the risk of term low birthweight and small for gestational age infants in both single and co-pollutant models. Term low birthweight and small for gestational age were determined using all birth certificates from North Carolina from 2003 to 2005. Ambient air concentrations of PM2.5 and O3 ...


Affluent Populations And Their Effect On Biological Diversity Through The Consumption Of Meat, Electronics, And Motor Vehicles, Melody Flores 2014 Pace University

Affluent Populations And Their Effect On Biological Diversity Through The Consumption Of Meat, Electronics, And Motor Vehicles, Melody Flores

Honors College Theses

The human has caused a far greater impact on the planet's biodiversity than any other species in existence, due to the impact of population, afflluence, and technology. This thesis will argue the importance of biological diversity and how affluent populations are reducing biodiversity through the consumption of meat, electronics, and motor vehicles. Aldo Leopold's "The Land Ethic" and Herman Daly's "The Impossibility Theorem", among others, create a rubric evaluating human activities and provide alternative views on economic impossibilities. Consumption is reviewed from an ecocentric perspective, a holistic outlook placing emphasis on the ecosystem. The reader will become ...


Exposure To Environmental Contaminants And Stress As Determinants Of Health In Three Communities: Walpole Island And Attawapiskat First Nations And Naivasha, Kenya, Deirdre Phaedra Henley 2014 Western University

Exposure To Environmental Contaminants And Stress As Determinants Of Health In Three Communities: Walpole Island And Attawapiskat First Nations And Naivasha, Kenya, Deirdre Phaedra Henley

University of Western Ontario - Electronic Thesis and Dissertation Repository

This project is an interdisciplinary, community-based, participatory Ecosystem Health investigation with two First Nations in Canada, one located in the far south (Walpole Island; WIFN) and one in the far north (Attawapiskat; AttFN), and a large Kenyan community surrounding Lake Naivasha. The increased human health risks from exposure to three classes of environmental contaminants, persistent organic pollutants (POPs), pesticides and metals, and fear from such exposures are pressing concerns in each setting. Sensitive analysis of 15 metals in hair, six metals and 91 POPs in whole blood or serum of WIFN and AttFN volunteers has been conducted. Whole blood samples ...


Ligand-Receptor Interactions For Supramolecular Disassembly With Applications In Screening And Drug Delivery, Diego F. Amado Torres 2014 SelectedWorks

Ligand-Receptor Interactions For Supramolecular Disassembly With Applications In Screening And Drug Delivery, Diego F. Amado Torres

Diego Amado Torres

Proteins have the capacity to bind specific sets of compounds known as ligands, these are small molecules with a recurrent theme in their molecular design that is a characteristic exploited here to (i) identify particular affinities of small molecules for proteins with the aim of using them as ligands, inhibitors, or targeting moieties in more complex systems by means of a methodology that screens small molecules based on protein affinity; (ii) decorate a self-assembling supramolecular system at different positions, making it responsive to a complementary protein with the aim of exploring differences in disassembly and sensitivity of the release of ...


Erythropoietin And Chronic Kidney Disease Alter Hepatic Expression Of Cytochrome P450 Enzymes And Drug Transport Proteins, David A. Feere 2014 Western University

Erythropoietin And Chronic Kidney Disease Alter Hepatic Expression Of Cytochrome P450 Enzymes And Drug Transport Proteins, David A. Feere

University of Western Ontario - Electronic Thesis and Dissertation Repository

Chronic kidney disease (CKD) is a progressive disease involving the irreversible loss of kidney function. Patients with CKD require concurrent dosing of many medications to manage their disease and associated comorbidities. Pharmacokinetic studies using patients with CKD and previous studies using animal models of CKD have demonstrated changes in hepatic drug metabolism and transport. Our studies aim to examine the effects that end-stage renal disease (ESRD) and continuous dosing of recombinant human erythropoietin (EPO) have on hepatic cytochrome P450 (P450) drug metabolizing enzymes and drug transport proteins. We used an adenine-fed rat model of CKD to demonstrate that EPO decreases ...


Chemical Profiling And Biological Activity Of Two Tunicate-Associated Marine Bacteria, Lyubina Yankova 2014 University of Connecticut

Chemical Profiling And Biological Activity Of Two Tunicate-Associated Marine Bacteria, Lyubina Yankova

Honors Scholar Theses

Marine natural products have recently been an increasingly abundant source of novel antibiotics. Given that there is an increasing resistance to current drug therapies, finding new sources such as marine natural products is essential. Tunicate-associated marine bacteria can be a significant source of antibacterial compounds. Two tunicates of the species Eudistoma were collected from Portobelo National Park on the Salmedina Reef of Panama in the Caribbean Sea. Bacteria associated with the tunicate were isolated, cultured, extracted, and fractionated. Fractions were tested against an array of clinically relevant bacterial pathogens in the BioMAP assay. Two fractions MB0086E and MB0088E demonstrated activity ...


Bioplastics: Reinventing Conventional Plastic Production And The Future Of Biodegradable Materials, Ruby Roca 2014 Fordham University

Bioplastics: Reinventing Conventional Plastic Production And The Future Of Biodegradable Materials, Ruby Roca

2014 Student Theses

The use of plastic is prevalent in our society due to the increasing amount of new products entering the market that need some form of packaging that is solid enough yet disposable. From everything to yogurt containers to diapers, plastic containers are a large part of our society’s consumption culture and often goes unnoticed. However, people point to plastic water bottles and containers as the only culprit, and often times forget that almost all packaging contains some form of plastic. For my thesis I want to examine how the use of plastics has increased waste material, considering that it ...


Water Water Everywhere: Analyzing Long Island's Water Issues And Finding Solutions For A Sustainable Future, Anthony T. Becker 2014 Fordham University

Water Water Everywhere: Analyzing Long Island's Water Issues And Finding Solutions For A Sustainable Future, Anthony T. Becker

2014 Student Theses

Over three million people call Long Island their home. With access to beautiful landscapes, world-renowned beaches, and proximity to New York City, it is no wonder that so many proudly call this geographic stretch of glacial till their home. However, throughout the years our actions do not necessarily reflect this affection we have to our home. Years of sprawl and human infestation across the island have resulted in widespread environmental degradation. Specifically, the water we drink and the beaches we enjoy have become endangered. I plan on studying the urban ecology of how intensified population growth led to the eutrophication ...


American Ginseng Modulation Of Immune Function And Phytochemical Analysis, Chike G. Azike 2014 Western University

American Ginseng Modulation Of Immune Function And Phytochemical Analysis, Chike G. Azike

University of Western Ontario - Electronic Thesis and Dissertation Repository

The relationship between American ginseng immunostimulatory and immunoinhibitory effects and the unique bioactive fractions of its different extracts namely aqueous (AQ) and alcoholic (ALC) extracts was investigated. AQ extract up-regulated the production of nitric oxide (NO), tumour necrosis factor-α (TNF-α) and interleukin-6 (IL-6), while ALC extract did not upregulate macrophage function. ALC extract but not AQ extract suppressed lipopolysaccharide (LPS) induced macrophage NO and TNF-α production. Macrophage-stimulating activity of the AQ extract was inhibited in the presence of ALC extract. Fractionation of AQ extract revealed that its crude polysaccharides (PS) are the only immunostimulatory phytochemical. Fractionation study of ALC extract ...


Health Hazards In Rental Housing: An Overview Of Clark County, Nevada, Amanda Nicole Sokolowsky 2014 University of Nevada, Las Vegas

Health Hazards In Rental Housing: An Overview Of Clark County, Nevada, Amanda Nicole Sokolowsky

UNLV Theses/Dissertations/Professional Papers/Capstones

A wide range of health conditions are associated with housing conditions, including asthma, respiratory infections, injuries, mental health issues, and lead poisoning. People in modern societies spend more than 90% of their time indoors, the vast majority of which is spent at home. Therefore, any new information on housing related health hazards in a population provides an opportunity for a new prevention program. Reports have shown that rental properties have more health related hazards than owner occupied housing, and rental properties are frequently occupied by low-income and minority individuals. This descriptive study intended to provide an overview of housing related ...


Evaluating The Impact Of A Home-~Based Childhood Asthma Intervention Program In Clark County, Nevada, Mackenzie Suzanne Burns 2014 University of Nevada, Las Vegas

Evaluating The Impact Of A Home-~Based Childhood Asthma Intervention Program In Clark County, Nevada, Mackenzie Suzanne Burns

UNLV Theses/Dissertations/Professional Papers/Capstones

Asthma is a chronic, incurable, costly, and potentially life–threatening disease that affects an estimated 7 million children in the United States; further, more than 56,000 Nevada children are currently living with asthma. The literature suggests that a number of factors that contribute to either the development of asthma or the exacerbation of asthma symptoms in sensitive individuals can be traced to the home environment. Given that the majority of Americans spend over 90% of their time indoors, of which two–thirds are spent at home, a home–based childhood asthma intervention program represents a unique primary prevention opportunity ...


Development Of A Molecular Method For Detecting The Causative Agent Of Swimmer's Itch (Trichobilharzia) In Freshwater Ecosystems, Heidi Mcmaster 2014 University of Nevada, Las Vegas

Development Of A Molecular Method For Detecting The Causative Agent Of Swimmer's Itch (Trichobilharzia) In Freshwater Ecosystems, Heidi Mcmaster

UNLV Theses/Dissertations/Professional Papers/Capstones

Cercarial dermatitis, commonly known as swimmer's itch, is caused by penetration of larvae of the schistosome,Trichobilharzia, into the dermis and epidermis layers of the skin. Symptoms are characterized by painful swelling and itching at the site of penetration. The normal hosts for the life cycle of the schistosome are aquatic birds and aquatic snails. The most frequently used method of detection forTrichobilharziais microscopy. With increases in the occurrence of cercarial dermatitis outbreaks in freshwater in the Southwestern United States, it is becoming increasingly important to develop and standardize a molecular method for rapid detection that can assist health ...


Environews #9: The Sunshine State Is In A State., Richard B. Philp 2014 Western University

Environews #9: The Sunshine State Is In A State., Richard B. Philp

Richard B. Philp

Sewage contamination and fertilizer runoff are polluting Florida's springs and rivers and legislative protection is weak. Lion fish are invading northern Gulf waters.


Role Of Gluk1 Kainate Receptors In Seizures, Epileptic Discharges, And Epileptogenesis, Brita Fritsch, Janine Reis, Maciej Gasior, Rafal M. Kaminski, Michael A. Rogawski 2014 SelectedWorks

Role Of Gluk1 Kainate Receptors In Seizures, Epileptic Discharges, And Epileptogenesis, Brita Fritsch, Janine Reis, Maciej Gasior, Rafal M. Kaminski, Michael A. Rogawski

Michael A. Rogawski

Kainate receptors containing the GluK1 subunit have an impact on excitatory and inhibitory neurotransmission in brain regions, such as the amygdala and hippocampus, which are relevant to seizures and epilepsy. Here we used 2-amino-3-(3-hydroxy-5-tert-butylisoxazol-4-yl) propanoic acid (ATPA), a potent and selective agonist of kainate receptors that include the GluK1 subunit, in conjunction with mice deficient in GluK1 and GluK2 kainate receptor subunits to assess the role of GluK1 kainate receptors in provoking seizures and in kindling epileptogenesis. We found that systemic ATPA, acting specifically via GluK1 kainate receptors, causes locomotor arrest and forelimb extension (a unique behavioral characteristic of ...


Effect Of Ascorbate On Coagulation And Fibrinolytic Factors In The Septic Microvasculature, Scott Swarbreck 2014 Western University

Effect Of Ascorbate On Coagulation And Fibrinolytic Factors In The Septic Microvasculature, Scott Swarbreck

University of Western Ontario - Electronic Thesis and Dissertation Repository

Sepsis, a systemic inflammatory response to an infection, is a significant cause of morbidity and mortality worldwide. The microcirculation during sepsis fails, in part, due to microthrombosis and the resulting plugging of capillaries, precipitating organ failure. Intravenous injection of ascorbate has been shown to reduce capillary plugging, however the mechanism of this protective effect is unclear. We hypothesized that ascorbate-mediated destabilization of the microthrombi through promoting fibrinolysis could contribute to this protection.

We showed that streptokinase, a pro-fibrinolytic agent, reduced the capillary plugging to a similar degree as ascorbate. This similarity provided the impetus for studying the effect of ascorbate ...


Sirna Targeting Of Thymidylate Synthase, Thymidine Kinase 1 And Thymidine Kinase 2 As An Anticancer Therapy: A Combinatorial Rnai Approach, Christine Di Cresce 2014 Western University

Sirna Targeting Of Thymidylate Synthase, Thymidine Kinase 1 And Thymidine Kinase 2 As An Anticancer Therapy: A Combinatorial Rnai Approach, Christine Di Cresce

University of Western Ontario - Electronic Thesis and Dissertation Repository

Thymidylate synthase (TS) is the only de novo source of thymidylate (dTMP) for DNA synthesis and repair. Drugs targeting TS protein are a mainstay in cancer treatment but off-target effects and toxicity limit their use. Cytosolic thymidine kinase (TK1) and mitochondrial thymidine kinase (TK2) contribute to an alternative dTMP-producing pathway, by salvaging thymidine from the tumour milieu, and may modulate resistance to TS-targeting drugs. We have previously shown that TS antisense molecules (oligodeoxynucleotides, ODNs, and small interfering siRNA, siRNA) sensitize tumour cells, both in vitro and in vivo, to TS targeting drugs. As both TS and TKs contribute to cellular ...


Platinum (Pt) Nanoparticles In Metal-Organic-Framework (Mof): Evaluating The Catalytic Performance In Selective Hydrogenation Of Cinnamaldehyde, Hannah Giang 2014 Iowa State University

Platinum (Pt) Nanoparticles In Metal-Organic-Framework (Mof): Evaluating The Catalytic Performance In Selective Hydrogenation Of Cinnamaldehyde, Hannah Giang

Symposium on Undergraduate Research and Creative Expression

The hydrogenation of carbonyl group of cinnamaldehyde (CALD) yields a desired product, which is cinnamyl alcohol (CALC), along with a couple byproducts, which are hydrocinnamaldehyde (HCALD) and hydrocinnamyl alcohol (HCALC). Recently, metal-organic frameworks (MOFs) are shown to be a new kind of porous material that has great potential in catalysis due to their large surface area and high porosity. In this project, small platinum (Pt) nanoparticles encaged in metal-organic-framework (MOF), particularly UiO-66, were prepared to achieve the selective hydrogenation of cinnamaldehyde. The amine-functionalized MOF (UiO-66-NH2) was found to be able to achieve much higher Pt loading than the pristine, UiO-66 ...


Exploration Of Freshwater Cyanobacteria, Mariya Campbell 2014 Georgia State University

Exploration Of Freshwater Cyanobacteria, Mariya Campbell

Georgia State Undergraduate Research Conference

No abstract provided.


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