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Waste To Phosphorus: A Transdisciplinary Solution To P Recovery From Wastewater Based On The Triz Approach, Anna Jama-Rodzeńska, Andrzej Białowiec, Jacek A. Koziel, Józef Sowiński 2021 Wroclaw University of Environmental and Life Sciences

Waste To Phosphorus: A Transdisciplinary Solution To P Recovery From Wastewater Based On The Triz Approach, Anna Jama-Rodzeńska, Andrzej Białowiec, Jacek A. Koziel, Józef Sowiński

Agricultural and Biosystems Engineering Publications

Phosphorus (P) is a limited yet essential resource. P cannot be replaced, but it can be recovered from waste. We proposed the TRIZ approach (Teoria reszenija izobretatielskich zadacz - Rus., Theory of Inventive Problem Solving - Eng.) to identify a feasible solution. We aimed at minimizing the environmental impact and, by eliminating contradictions, proposed viable technical solutions. P recovery can be more sustainable based on circular economy and 4Rs (reduction, recovery, reuse, and recycling). The TRIZ approach identified sewage sludge (SS) as waste with a large potential for P recovery (up to 90%). Successful selection and application of SS management and P ...


Pathogenesis Of Dry Eye In Graft Versus Host Disease (Gvhd): Role Of Ocular Mucins And Conjunctival Fibrosis, Kiumars Shamloo 2021 Chapman University

Pathogenesis Of Dry Eye In Graft Versus Host Disease (Gvhd): Role Of Ocular Mucins And Conjunctival Fibrosis, Kiumars Shamloo

Pharmaceutical Sciences (PhD) Dissertations

Allogenic hematopoietic stem cell transplantation is a procedure that offers a possible cure for hematologic cancers and other hematologic disorders. Unfortunately, despite the increasing survival rate of patients, the quality of their life is adversely affected by the allogeneic bone marrow transplantation’s major side effect i.e Graft vs. Host Disease (GVHD). GVHD is a complex, multi-organ disease resulting from an immunological attack by donor engrafted immune cells to host organs, including the eye surface. Mostly based on the time of disease onset after transplantation, GVHD is divided into the acute and chronic phase. The eyes may be involved ...


Mitigation Of Acute Ammonia Emissions With Biochar During Swine Manure Agitation Before Pump-Out: Proof-Of-The-Concept, Baitong Chen, Jacek A. Koziel, Andrzej Białowiec, Myeongseong Lee, Hantian Ma, Samuel C. O'Brien, Peiyang Li, Zhanibek Meiirkhanuly, Robert C. Brown 2021 Iowa State University

Mitigation Of Acute Ammonia Emissions With Biochar During Swine Manure Agitation Before Pump-Out: Proof-Of-The-Concept, Baitong Chen, Jacek A. Koziel, Andrzej Białowiec, Myeongseong Lee, Hantian Ma, Samuel C. O'Brien, Peiyang Li, Zhanibek Meiirkhanuly, Robert C. Brown

Agricultural and Biosystems Engineering Publications

Ammonia (NH3) emissions from animal agriculture can cause eutrophication of water ecosystems and are precursors to secondary particulate matter (PM2.5). NH3 emissions from stored swine manure represent nutrient loss affecting the fertilizing value of manure. The short-term emission bursts occur when farmers agitate manure before emptying storage and fertilizing fields. There is no proven technology to mitigate gaseous emissions during agitation, while the hazards of acute releases (e.g., H2S) are well-known. Biochar mitigates NH3 emissions from manure over the long-term. The objective of this research was to evaluate the mitigation of acute NH3 emissions during/after agitation. Two ...


Modern Approaches For Antiandrogen-Resistant Prostate Cancer Therapy, Felix Voinea, Laura Mazilu, Ioan Sergiu Micu, Adrian Paul Suceveanu, Madalina Iliescu, Andrada Dumitru, Vlad Denis Constantin, Ioana Paunica, Andra Iulia Suceveanu 2021 OVIDIUS UNIVERSITY, FACULTY OF MEDICINE, DEPARTMENT OF UROLOGY, CONSTANTA, ROMANIA

Modern Approaches For Antiandrogen-Resistant Prostate Cancer Therapy, Felix Voinea, Laura Mazilu, Ioan Sergiu Micu, Adrian Paul Suceveanu, Madalina Iliescu, Andrada Dumitru, Vlad Denis Constantin, Ioana Paunica, Andra Iulia Suceveanu

Journal of Mind and Medical Sciences

Prostate cancer represents the leading malignant tumor in men over 50 years of age with 400,000 new cases being diagnosed yearly in Europe. Even if the incidence rate is higher than the mortality rate, still there is an increasing trend when speaking of its mortality. The increasing incidence of the metabolic syndrome, the unhealthy lifestyle, the high lipid and Calcium intake, the high spread of infections with Human Papilloma Virus, Human Herpes Virus, the excess of androgen consumption and the longer life expectancy, are few of the main causes of prostate cancer increasing incidence. The new systemic therapies such ...


Synthesis Of 1-(4-Ethoxy-3-Methoxybenzyl)-1,10-Phenanthrolin-1-Ium Bromide And Its Evaluation As Antiplasmodium Through Heme Polymerization Inhibitory Activity (Hpia) Assay, Dhina Fitriastuti, Viny Alfiyah, Mustofa Mustofa, Jumina Jumina, Muhammad Idham Darussalam Mardjan 2021 Department of Chemistry, Faculty of Mathematics and Natural Sciences, Universitas Islam Indonesia, Yogyakarta 55584, Indonesia

Synthesis Of 1-(4-Ethoxy-3-Methoxybenzyl)-1,10-Phenanthrolin-1-Ium Bromide And Its Evaluation As Antiplasmodium Through Heme Polymerization Inhibitory Activity (Hpia) Assay, Dhina Fitriastuti, Viny Alfiyah, Mustofa Mustofa, Jumina Jumina, Muhammad Idham Darussalam Mardjan

Makara Journal of Science

This study describes the development of N-benzyl-1,10-phenantrolinium salt as an antiplasmodium agent. The salt, that is, 1-(4-ethoxy-3-methoxybenzyl)-1,10-phenanthrolin-1-ium bromide, was prepared using vanillin as the starting material in four simple synthetic steps. First, the alkylation of vanillin using diethyl sulfate produced 4-ethoxy-3-methoxybenzaldehyde in 79% yield. Second, the reduction of the protected vanillin by NaBH4 through the grinding method allowed us to obtain 4-ethoxy-3-methoxybenzyl alcohol in 96% yield. Next, the bromination of the benzyl alcohol under solvent-free condition led to the formation of the corresponding benzyl bromide, which in turn underwent bimolecular nucleophilic substitution with 1 ...


Use Of A Zebrafish Model To Identify Anticonvulsant Properties Of Cannabinoid And Terpenoid Extracts And Mixtures, Courtney Murr 2021 Louisiana State University

Use Of A Zebrafish Model To Identify Anticonvulsant Properties Of Cannabinoid And Terpenoid Extracts And Mixtures, Courtney Murr

LSU Master's Theses

Epilepsy is a complex group of neurological disorders affecting approximately 65 million people worldwide. Animal models reveal the activation of cannabinoid receptor 1 and cannabinoid receptor 2 reduces the severity of seizures associated with epilepsy. Trials of phytocannabinoids in mammals demonstrate their efficacy of reducing the severity of epileptic seizures. Numerous terpenoid compounds are present in Cannabis plants but most have yet to be clinically investigated. The goal of this research was to use zebrafish (Danio rerio) to identify the potential anticonvulsive properties of phytocannabinoid and terpenoid compounds. During acute cannabinoid exposures, 7-days-post-fertilization (7 dpf) zebrafish larvae were exposed to ...


Mitigation Of Odor And Gaseous Emissions From Swine Barn With Uv-A And Uv-C Photocatalysis, Myeongseong Lee, Jacek A. Koziel, Wyatt Murphy, William S. Jenks, Baitong Chen, Peiyang Li, Chumki Banik 2021 Iowa State University

Mitigation Of Odor And Gaseous Emissions From Swine Barn With Uv-A And Uv-C Photocatalysis, Myeongseong Lee, Jacek A. Koziel, Wyatt Murphy, William S. Jenks, Baitong Chen, Peiyang Li, Chumki Banik

Agricultural and Biosystems Engineering Publications

UV-A (ca. 365 nm wavelength, a.k.a. 'black light') photocatalysis has been investigated to comprehensively mitigate odor and selected air pollutants in the livestock environment. This study was conducted to confirm the performance of UV-A photocatalysis on the swine farm. The objectives of this research were to (1) scale-up of the UV-A photocatalysis treatment, (2) evaluate the mitigation of odorous gases from swine slurry pit, and (3) test different UV sources, (4) evaluate the effect of suspended particulate matter (PM), and (5) conduct preliminary economic analyses. We tested UV-A photocatalysis at a mobile laboratory-scale capable of treating ~0.2 ...


New Psychoactive Substances In Taiwan: The Current Situation And Initiative For Rational Scheduling, Wen-Jing Yu, Linda B. Cottler, Jih-Heng Li 2021 Degree Program, College of Pharmacy, Kaohsiung Medical University, Taiwan

New Psychoactive Substances In Taiwan: The Current Situation And Initiative For Rational Scheduling, Wen-Jing Yu, Linda B. Cottler, Jih-Heng Li

Journal of Food and Drug Analysis

Use of New Psychoactive Substances (NPS) has posed a global threat to public health and the security of the population. As of December 2019, the NPS items identified in total have outnumbered by three to one the controlled substances listed in the 1961 and 1971 UN Drug Conventions. However, most of these NPS have not been scheduled by the United Nations because of their easy modification on the chemical structures to shun control. Currently, the scheduling and control of NPS is mostly at the national level and a rational scheduling of NPS by objective assessments is essential but often lacking ...


A Convenient And Sensitive Colorimetric Iodide Assay Based On Directly Inducing Morphological Transformation Of Gold Nanostars, Rongju Zhou, Xiaohui Huang, Qingxiao An, Weizhen Xu, Yi LIu, Dong Xu, Suyan Wang, Qinlu Lin, Jianglin Zhang 2021 Central South University of Forestry & Technology, China

A Convenient And Sensitive Colorimetric Iodide Assay Based On Directly Inducing Morphological Transformation Of Gold Nanostars, Rongju Zhou, Xiaohui Huang, Qingxiao An, Weizhen Xu, Yi Liu, Dong Xu, Suyan Wang, Qinlu Lin, Jianglin Zhang

Journal of Food and Drug Analysis

We propose a convenient and easy colorimetric assay for highly sensitive detection of iodide by using gold nanostars (GNSs) as probes. The assay relies on that iodide directly changes the morphology of GNSs and alters their longitudinal localized surface plasmon resonance (LSPR) without surface modifications and the use of other reagents. Upon increasing iodide concentration, GNSs gradually transformed to sphere gold nanoparticles, the absorbance at longitudinal LSPR decreased, and solution color varied from greenish blue to red, as confirmed by the UV-Vis absorption spectroscopy and transmission electron microscopy. With this strategy, as low as 0.005 μM of iodide can ...


Quercetin Blocks The Aggressive Phenotype Of Triple Negative Breast Cancer By Inhibiting Igf1/Igf1r-Mediated Emt Program, Wei-Jen Chen, Jie-Heng Tsai, Li-Sung Hsu, Chih-Li Lin, Hui-Mei Hong, Min-Hsiung Pan 2021 Department of Biomedical Sciences, Chung Shan Medical University

Quercetin Blocks The Aggressive Phenotype Of Triple Negative Breast Cancer By Inhibiting Igf1/Igf1r-Mediated Emt Program, Wei-Jen Chen, Jie-Heng Tsai, Li-Sung Hsu, Chih-Li Lin, Hui-Mei Hong, Min-Hsiung Pan

Journal of Food and Drug Analysis

The cancer-preventive activities of quercetin have been extensively studied in invasive breast cancer; however, the role of quercetin on triple-negative breast cancer (TNBC) with overexpression of insulin-like growth factor-1 receptor (IGF1R) has not been resolved. In this article, we demonstrated that quercetin inhibited the activation of IGF1R and its downstream kinases Akt and Erk1/2 in a dose-dependent manner in human MDA-MB-231 breast cancer cells (TNBC cell line). Related to this, quercetin markedly suppressed the metastatic phenotype and epithelial–mesenchymal transition (EMT) of MDA-MB-231 cells by inhibiting the expression of EMT transcription factors Snail and Slug. Quercetin also increased the ...


N-Nitrosodimethylamine (Ndma) Contamination Of Ranitidine Products: A Review Of Recent Findings, Fahad S. Aldawsari, Yahya M. Alshehri, Thamer S. Alghamdi 2021 Drug Reference Laboratory, Saudi Food and Drug Authority

N-Nitrosodimethylamine (Ndma) Contamination Of Ranitidine Products: A Review Of Recent Findings, Fahad S. Aldawsari, Yahya M. Alshehri, Thamer S. Alghamdi

Journal of Food and Drug Analysis

Ranitidine is a medication that has been used to alleviate heartburn and other disorders for over 40 years. Following reports of N-nitrosodimethylamine (NDMA) contamination in ranitidine products, there have been many recalls and registration suspensions. Here, we revise the literature information confirming ranitidine association with NDMA. Then, we highlight the documented mechanisms for NDMA release from ranitidine. In addition, the stability issue for this medicine is discussed. After that, we review and discuss the results of the United States Food and Drug Administration and the Australian Therapeutic Goods Administration laboratory testing of ranitidine products and the detected NDMA levels. Finally ...


The Bioactivities Of Resveratrol And Its Naturally Occurring Derivatives On Skin, Ming-Hsien Lin, Chi-Feng Hung, Hsin-Ching Sung, Shih-Chun Yang, Huang-Ping Yu, Jia-You Fang 2021 Chi Mei Medical Center, Taiwan

The Bioactivities Of Resveratrol And Its Naturally Occurring Derivatives On Skin, Ming-Hsien Lin, Chi-Feng Hung, Hsin-Ching Sung, Shih-Chun Yang, Huang-Ping Yu, Jia-You Fang

Journal of Food and Drug Analysis

Resveratrol has been extensively reported as a potential compound to treat some skin disorders, including skin cancer, photoaging, allergy, dermatitis, melanogenesis, and microbial infection. There has been an increasing interest in the discovery of cosmetic application using resveratrol as the active ingredient because of its anti-aging and skin lightening activities. The naturally occurring derivatives of resveratrol also exert a beneficial effect on the skin. There are four groups of resveratrol derivatives, including hydroxylated compounds, methoxylated compounds, glycosides, and oligomers. The major mechanism of resveratrol and its derivatives for attenuating cutaneous neoplasia, photoaging and inflammation, are related with its antioxidative activity ...


Suitability Of Sugar Alcohols As Antidiabetic Supplements: A Review, Nontokozo Z. Msomi, Ochuko L. Erukainure, Md. Shahidul Islam 2021 University of KwaZulu-Natal, Durban, South Africa

Suitability Of Sugar Alcohols As Antidiabetic Supplements: A Review, Nontokozo Z. Msomi, Ochuko L. Erukainure, Md. Shahidul Islam

Journal of Food and Drug Analysis

The major goals in the management of diabetes are to maintain normal control of glucose metabolism and glycemia. Dietary modification is one of the most recommended treatment modalities for diabetic patients. The use of foods sweetened with sugar alcohols (also known as polyols) such as xylitol, sorbitol, mannitol, maltitol, lactitol, isomalt and erythritol, has brought an escalating interest. Since some sugar alcohols do not raise plasma glucose, as they are partially digested and metabolised. Diet composition and adequacy may be altered by replacing carbohydrates with sugar alcohols. It has been established that these polyols are appropriate sugar substitutes for a ...


Microbiological Study In A Gneissic Cave From Sri Lanka, With Special Focus On Potential Antimicrobial Activities, Ethige Isuru P. Silva, Pathmakumara Jayasingha, Saman Senanayake, Anura Dandeniya, Dona Helani Munasinghe 2021 University of Sri Jayewardenepura, Sri Lanka

Microbiological Study In A Gneissic Cave From Sri Lanka, With Special Focus On Potential Antimicrobial Activities, Ethige Isuru P. Silva, Pathmakumara Jayasingha, Saman Senanayake, Anura Dandeniya, Dona Helani Munasinghe

International Journal of Speleology

The emergence of antibiotic resistance is a global health crisis, thus the search for novel antimicrobial compounds has become a continuous necessity. Underexplored and extreme environments, such as cave ecosystems, have been identified as a promising potential source for the discovery of novel microorganisms with novel antimicrobial compounds (AMC). This study presents the first cave microbiological investigation in Sri Lanka, with a special preference for bioprospecting of novel AMC. The cave sediment characterization demonstrated the presence of close to strong acidic conditions (pH 3.1 – 3.3) and thus indicates the possibility of isolating acidophilic microorganisms. Eight cave wall/ceiling ...


Mapping Km Methods And Tools Across The Pharmaceutical Product Lifecycle, Martin Lipa, Paige Kane 2021 TuDublin

Mapping Km Methods And Tools Across The Pharmaceutical Product Lifecycle, Martin Lipa, Paige Kane

Level 3

Knowledge management is positioned as an enabler of ICH Q10, and the visibility and availability of product and process knowledge across the entire pharmaceutical product lifecycle is vital to the sustained success of an organization and to the effectiveness of an organization’s pharmaceutical quality system as defined by ICH Q10. This paper illustrates where knowledge management has a role to play within each product lifecycle phase. This paper goes on to further define phase-appropriate KM methods and tools to help address these needs and create end-to-end product and process knowledge visibility and availability.


Women Water Leaders In The Making: South Asian Water Leadership Programme On Climate Change, Sreenita Mondal, Mansee Bal Bhargava, Mélanie Robertson 2021 Research Fellow, South Asia Consortium for Interdisciplinary Water Resources Studies

Women Water Leaders In The Making: South Asian Water Leadership Programme On Climate Change, Sreenita Mondal, Mansee Bal Bhargava, Mélanie Robertson

wH2O: The Journal of Gender and Water

The South Asia Consortium for Interdisciplinary Water Resources Studies (Saci- WATERs) a water policy research institute based in Hyderabad, India, launched the South Asian Water (SAWA) Leadership Programme on climate change in 2017. The SaciWATERs is hosting the programme in collaboration with four partner engineering institutes from four South Asian countries, and with funding support from the International Development Research Centre (IDRC), Canada. This academic-oriented programme is aimed at facilitating the creation of a group of interdisciplinary women leaders in South Asia that share a common understanding of the crosscutting scientific and societal issues of water resource management. The four-year ...


Eleanor Allen: On A Mission To Provide Safe Water For Everyone, Forever, wH2O staff 2021 University of Pennsylvania

Eleanor Allen: On A Mission To Provide Safe Water For Everyone, Forever, Wh2o Staff

wH2O: The Journal of Gender and Water

Eleanor Allen is a global water expert dedicated to helping millions of people access the safe and sustainable water and sanitation services needed to save lives, stay healthy, earn more money, and thrive. Eleanor is fiercely passionate about improving the state of the world with respect to water and sanitation. She has dedicated her career to this goal, first as a Peace Corps volunteer in the Dominican Republic, then as a consulting engineer (at CH2M/Jacobs and Arcadis), and now as the CEO of Water For People. Eleanor has lived and worked all over the world. As a professional civil ...


Addressing Women’S Sanitation-Related Safety Concerns In Slums Of Maharashtra, India, Mehul Banka, Pratima Joshi, Smita Kale 2021 University of Pennsylvania

Addressing Women’S Sanitation-Related Safety Concerns In Slums Of Maharashtra, India, Mehul Banka, Pratima Joshi, Smita Kale

wH2O: The Journal of Gender and Water

Through this paper we explore women’s vulnerability during sanitation activities and the impact that household toilets have on women’s safety-related concerns. This study covers 4 cities in the state of Maharashtra– Pune, Pimpri- Chinchwad, Thane, and Kolhapur - where Shelter Associates has provided many slum households with toilets under its One Home One Toilet (OHOT) programme. A good part of the programme’s intention is to offer women an alternative to using their existing, inadequate public sanitation facilities, a problem that was highlighted during discussions with slum women themselves. Shelter Associates is a Maharashtra-based NGO established in 1993 that ...


Pushing Forward In The Changing Water Sector: An Interview With Kishia L. Powell, Coo, Dc Water, Abigail Drabick 2021 University of Pennsylvania

Pushing Forward In The Changing Water Sector: An Interview With Kishia L. Powell, Coo, Dc Water, Abigail Drabick

wH2O: The Journal of Gender and Water

Kishia Powell is a licensed Professional Engineer in the District of Columbia, Virginia and Maryland. She holds a Bachelor of Science degree in Civil Engineering from Morgan State University’s Clarence M. Mitchell, Jr. School of Engineering. Currently, Powell is Chief Operating Officer at DC Water, where she manages 80% of the water authority’s resources. With over 22 years of experience, Kishia Powell sheds light on the value of water, her experience as a leader and a woman in the water utilities industry, the COVID-19 pandemic, and climate change in this interview with The Journal of Gender and Water ...


Here, There, And Everywhere: The Problem With Microplastics In Water And What Women Scientists Are Doing To Solve It, Pamela Lazos 2021 University of Pennsylvania

Here, There, And Everywhere: The Problem With Microplastics In Water And What Women Scientists Are Doing To Solve It, Pamela Lazos

wH2O: The Journal of Gender and Water

Plastics — ubiquitous material we cannot seem to live without — are everywhere, but sadly we cannot live with plastics either, at least not peaceably, especially when you consider there will be more plastics in the ocean than fish by 2050. In the intervening years, the photodegradation of plastic resulting in microplastics pollution will be an even bigger problem, affecting every living creature in the ocean, and by extrapolation, mankind. The choices we make and the steps we take to combat the overabundance of plastics in our environment will dictate not just the next 30 years, but the fate of the world ...


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