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Do You Really Want A Hunter-Gatherer Microbiota? Perils And Pitfalls For Your Gut, Michael Ruscio 2017 Dr. Michael Ruscio

Do You Really Want A Hunter-Gatherer Microbiota? Perils And Pitfalls For Your Gut, Michael Ruscio

Journal of Evolution and Health

Clinicians have long understood the immense impact the health of our gut has on things like weight, energy, depression, autoimmunity and more. With the recent advancements in microbiota research we have learned much more about this connection. Like never before we understand how we can alleviate chronic health conditions and enhance well-being through improving the health of the gut.

However, with this increased research has also come over speculation and ill-informed recommendations. This has high impact on today's healthcare professional or consumer who could unintentionally do harm. For example by replicating the microbiota of hunter-gatherers of Africa, we could ...


Pulmonary Surfactant Fortified With Cath-2 As A Novel Therapy For Bacterial Pneumonia, Brandon J. Baer 2017 University of Western Ontario

Pulmonary Surfactant Fortified With Cath-2 As A Novel Therapy For Bacterial Pneumonia, Brandon J. Baer

Western Research Forum

Background: Bacterial pneumonia is a leading cause of death worldwide, with high mortality rates persisting even after antibiotic treatment. Current treatments for pneumonia involve administration of antibiotics, however after the bacteria are killed they release toxic substances that induce inflammation and lung dysfunction. Host defense peptides represent a potential solution to this problem through their ability to down regulate inflammation. However, effective delivery to the lung is difficult because of the complex branching structure of the airways. My study addresses this delivery problem by using exogenous surfactant, a pulmonary delivery vehicle capable of improving spreading of these peptides throughout the ...


Chemogenetic Stimulation Of The Hypoglossal Neurons Improves Upper Airway Patency, Thomas Curado, Kenneth Fishbein, Huy Pho, Michael Brennick, Olga Dergacheva, David Mendelowitz, +several additional authors 2017 George Washington University

Chemogenetic Stimulation Of The Hypoglossal Neurons Improves Upper Airway Patency, Thomas Curado, Kenneth Fishbein, Huy Pho, Michael Brennick, Olga Dergacheva, David Mendelowitz, +Several Additional Authors

Pharmacology and Physiology Faculty Publications

Obstructive sleep apnea (OSA) is characterized by recurrent upper airway obstruction during sleep. OSA leads to high cardiovascular morbidity and mortality. The pathogenesis of OSA has been linked to a defect in neuromuscular control of the pharynx. There is no effective pharmacotherapy for OSA. The objective of this study was to determine whether upper airway patency can be improved using chemogenetic approach by deploying designer receptors exclusively activated by designer drug (DREADD) in the hypoglossal motorneurons. DREADD (rAAV5-hSyn-hM3(Gq)-mCherry) and control virus (rAAV5-hSyn-EGFP) were stereotactically administered to the hypoglossal nucleus of C57BL/6J mice. In 6–8 weeks genioglossus ...


Students Can Be Important Link Between Academia And Practice, Jason W. Marion, Charles D. Treser 2017 Eastern Kentucky University

Students Can Be Important Link Between Academia And Practice, Jason W. Marion, Charles D. Treser

EKU Faculty and Staff Scholarship

Editor’s Note: In an effort to promote the growth of the environmental health profession and the academic programs that fuel that growth, NEHA has teamed up with the Association of Environmental Health Academic Programs (AEHAP) to publish two columns a year in the Journal. AEHAP’s mission is to support environmental health education to ensure the optimal health of people and the environment. The organization works hand in hand with the National Environmental Health Science and Protection Accreditation Council (EHAC) to accredit, market, and promote EHAC-accredited environmental health degree programs. AEHAP focuses on increasing the environmental health workforce, supporting ...


Five-Hundred Life-Saving Interventions And Their Misuse In The Debate Over Regulatory Reform, Lisa Heinzerling 2017 University of New Hampshire

Five-Hundred Life-Saving Interventions And Their Misuse In The Debate Over Regulatory Reform, Lisa Heinzerling

RISK: Health, Safety & Environment

The author argues that John D. Graham, administrator of the Office of Information and Regulatory Affairs, holds strong anti-environmental biases and has perpetuated and encouraged a misrepresentation of his own research, which has largely influenced health, safety, and environmental regulation.


Review Of: Risk In The Modern Age: Social Theory, Science And Environmental Decision Making (Maurie J. Cohen, Ed.), Amy Cutler 2017 University of New Hampshire

Review Of: Risk In The Modern Age: Social Theory, Science And Environmental Decision Making (Maurie J. Cohen, Ed.), Amy Cutler

RISK: Health, Safety & Environment

Review of the book: Risk in the Modern Age: Social Theory, Science and Environmental Decision Making (Maurie J. Cohen, ed., St. Martin's Press 2000). List of Figures and Tables, List of Contributors, Preface, Index. ISBN 0-312-22216-5 [264 pp. $65.00. Hardbound, 175 Fifth Avenue, New York, NY 10010].


Workplace Pollution: Nuclear Safety, Ethics, And The Exploitation--Avoidance Argument, Kristin Shrader-Frechette 2017 University of New Hampshire

Workplace Pollution: Nuclear Safety, Ethics, And The Exploitation--Avoidance Argument, Kristin Shrader-Frechette

RISK: Health, Safety & Environment

The author reviews evidence of poor worker health and safety practices in United States Department of Energy nuclear facilities in contending that less protective standards for workplace hazards constitute an environmental injustice not rectified by a hazard pay premium.


Redressing The Silent Interim: Precautionary Action & Short Term Tests In Toxicological Risk Assessment, Timothy Riley 2017 University of New Hampshire

Redressing The Silent Interim: Precautionary Action & Short Term Tests In Toxicological Risk Assessment, Timothy Riley

RISK: Health, Safety & Environment

The author recommends that a stronger emphasis be placed on creating and implementing short-term tests that use iterative, conservative-based, tiered procedures in conjunction with a precautionary attitude during the interim phase of toxicological risk assessments.


Looking Back At Fluoridation, Allan Mazur 2017 University of New Hampshire

Looking Back At Fluoridation, Allan Mazur

RISK: Health, Safety & Environment

The author reviews the 50-year history of the debate over fluoridating drinking water as a public health measure.


Over A Decade Of Comparative Risk Analysis: A Review Of The Human Health Rankings, David M. Konisky 2017 University of New Hampshire

Over A Decade Of Comparative Risk Analysis: A Review Of The Human Health Rankings, David M. Konisky

RISK: Health, Safety & Environment

The author reviews a method for undertaking a cross-project comparison of comparative risk analyses to understand which environmental problem areas have been cited most as often posing the severest risks.


Niche By Basma Kavanagh, Vivian M. Hansen 2017 University of Calgary

Niche By Basma Kavanagh, Vivian M. Hansen

The Goose

Review of Basma Kavanagh's Niche.


Microbial Repopulation Following In Situ Star Remediation, Gavin Overbeeke 2017 The University of Western Ontario

Microbial Repopulation Following In Situ Star Remediation, Gavin Overbeeke

Electronic Thesis and Dissertation Repository

In situ STAR (Self-sustaining Treatment for Active Remediation) is an emerging remediation technology which uses smouldering combustion to destroy nonaqueous phase liquid (NAPL) contamination in the subsurface. Since STAR smouldering travels through contaminated soils slowly (~0.5 to 5 m/day) and subjects them to high temperatures (400–1000°C), it is expected that this technology will thoroughly dry and sterilize the zones which it treats. Further, soils surrounding the treatment zone which are not smouldered will be heated, although not smouldered, by virtue of their proximity to STAR, impacting microbial communities within them. Therefore, the objectives of this work ...


Genetic Targeting In Cerebellar Purkinje Cells: An Update., Anna Sługocka, Jan Wiaderkiewicz, Jaroslaw J Barski 2017 George Washington University

Genetic Targeting In Cerebellar Purkinje Cells: An Update., Anna Sługocka, Jan Wiaderkiewicz, Jaroslaw J Barski

Pharmacology and Physiology Faculty Publications

Since the last review paper published in Cerebellum in 2002 [1], there has been a substantial increase in the number of experiments utilizing transgenic manipulations in murine cerebellar Purkinje cells. Most of these approaches were made possible with the use of the Cre/loxP methodology and pcp2/L7 based Cre recombinase expressing transgenic mouse strains. This review aims to summarize all studies which used Purkinje cell specific transgenesis since the first use of mouse strain with Purkinje cell specific Cre expression in 2002.


A Case For Caution: An Evaluation Of Calabrese And Baldwin's Studies Of Chemical Hormesis, Kevin C. Elliott 2017 University of New Hampshire

A Case For Caution: An Evaluation Of Calabrese And Baldwin's Studies Of Chemical Hormesis, Kevin C. Elliott

RISK: Health, Safety & Environment

Suggesting a need for more research, Mr. Elliott argues that it is too soon for risk-assessment policy to account for recent challenges to a toxicological linear dose-response assumption.


Comparing The Epa Indoor Air Quality Personal Computer Model And Field Data, Arash Behravesh, Wilbur A. Spaul 2017 University of New Hampshire

Comparing The Epa Indoor Air Quality Personal Computer Model And Field Data, Arash Behravesh, Wilbur A. Spaul

RISK: Health, Safety & Environment

The authors recommend caution in using an EPA model for reconstructing past exposure events as well as for predicting future exposures.


Frequency Of Use And Perceived Credibility Of Information Sources And Variations By Socioeconomic Factors Among Savannah River Stakeholders, Bryan L. Williams, Alex Vallei, Sylvia Brown, Michael Greenberg 2017 University of New Hampshire

Frequency Of Use And Perceived Credibility Of Information Sources And Variations By Socioeconomic Factors Among Savannah River Stakeholders, Bryan L. Williams, Alex Vallei, Sylvia Brown, Michael Greenberg

RISK: Health, Safety & Environment

The authors examine the factors effecting credibility of risk communication in the communities surrounding the Savannah River Nuclear Weapons Site.


Environmentally-Mediated Epigenetic Effects: Uncovering The Fertile Soil In The Development Of Pediatric Cancer, Ahmed Mohammed Morsy, Eman Ahmed Hasan, Ameer Mohammed Abuelgheet, Ahmed Salaheldeen Hassan 2017 Assiut University, South Egypt Cancer Institute, Department of Pediatric Oncology

Environmentally-Mediated Epigenetic Effects: Uncovering The Fertile Soil In The Development Of Pediatric Cancer, Ahmed Mohammed Morsy, Eman Ahmed Hasan, Ameer Mohammed Abuelgheet, Ahmed Salaheldeen Hassan

Dr/ Ahmed Mohammed Morsy

Environmentally-induced epigenetic changes of gene regulation could result from chronic, lifelong exposure, to low doses of environmental toxicants, such as chemicals including, tobacco smoking and endocrine disrupting compounds, or to other environmental factors such as nutritional changes, and lifestyle-related conditions. These environmentally-acquired epigenetic marks may influence the control of gene regulation through DNA methylation, histone modification, or through a large set of non-coding RNAs (ncRNAs). These epigenetic effects might be passed on to the developing embryo and child as inheritable non-genetic marks, which recapitulate previous lifelong history of exposure to environmental influences that start from the stage of primordial germ ...


Chloroquine-Inducible Par-4 Secretion Is Essential For Tumor Cell Apoptosis And Inhibition Of Metastasis, Ravshan Burikhanov, Nikhil Hebbar, Sunil K. Noothi, Nidhi Shukla, James Sledziona, Nathália Araujo, Meghana Kudrimoti, Qing Jun Wang, David S. Watt, Danny R. Welch, Jodi Maranchie, Akihiro Harada, Vivek M. Rangnekar 2017 University of Kentucky

Chloroquine-Inducible Par-4 Secretion Is Essential For Tumor Cell Apoptosis And Inhibition Of Metastasis, Ravshan Burikhanov, Nikhil Hebbar, Sunil K. Noothi, Nidhi Shukla, James Sledziona, Nathália Araujo, Meghana Kudrimoti, Qing Jun Wang, David S. Watt, Danny R. Welch, Jodi Maranchie, Akihiro Harada, Vivek M. Rangnekar

Radiation Medicine Faculty Publications

The induction of tumor suppressor proteins capable of cancer cell apoptosis represents an attractive option for the re-purposing of existing drugs. We report that the anti-malarial drug, chloroquine (CQ), is a robust inducer of Par-4 secretion from normal cells in mice and cancer patients in a clinical trial. CQ-inducible Par-4 secretion triggers paracrine apoptosis of cancer cells and also inhibits metastatic tumor growth. CQ induces Par-4 secretion via the classical secretory pathway that requires the activation of p53. Mechanistically, p53 directly induces Rab8b, a GTPase essential for vesicle transport of Par-4 to the plasma membrane prior to secretion. Our findings ...


Transdermal Testosterone For Menopause-Related Hyposexual Desire Disorder: Current Guidelines And Provider Perceptions, Knowledge, And Practice, Kelly Christine White 2017 University of Vermont

Transdermal Testosterone For Menopause-Related Hyposexual Desire Disorder: Current Guidelines And Provider Perceptions, Knowledge, And Practice, Kelly Christine White

Graduate College Dissertations and Theses

Hypoactive sexual desire or low libido in women are collectively referred to as hypoactive sexual desire disorder (HSDD). HSDD is estimated to occur in 10% to 15% of adult women. HSDD is likely the most common female sexual dysfunction (FSD) in menopausal women. The hallmark of the diagnosis is personal distress and interpersonal difficulties resulting from low sex drive. Most women will not seek help for this problem. Studies have suggested that primary care providers and gynecologic healthcare providers report not feeling qualified to treat patients with sexual dysfunction, especially HSDD. Testosterone, specifically transdermal testosterone, has been suggested to play ...


From Yosemite To A Global Market: How Patagonia, Inc. Has Created An Environmentally Sustainable And Socially Equitable Model Of Supply-Chain Management, Mary-Clare Bosco 2017 Pomona College

From Yosemite To A Global Market: How Patagonia, Inc. Has Created An Environmentally Sustainable And Socially Equitable Model Of Supply-Chain Management, Mary-Clare Bosco

Pomona Senior Theses

There is an urgent pressure of the time (2016) to re-evaluate our patterns of consumption to adapt to changing climates and reduce waste and pollution. Because an immediate restructuring of global production strategies is not likely any time soon, industrial innovators are finding new ways of redesigning supply-chain management in efforts to move towards environmentally sustainable business in which all manufacturing practices are transparent. Patagonia, Inc. is a testament to the often-debated question of economic value in green business practices, and this thesis acts as an outline as to how they arrived at such an impressive presence in the business ...


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