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Pharmacokinetics Of Single Feeding Of Cannabidiol In Cattle: A Pilot Study, Haley Cornette 2023 Murray State University

Pharmacokinetics Of Single Feeding Of Cannabidiol In Cattle: A Pilot Study, Haley Cornette

Honors College Theses

Cannabidiol (CBD) is a substance that has been used in complementary medicine for many years. However, modern medicine has little knowledge of how this substance is utilized and metabolized in ruminant animals. Regulations on quality assurance and use in animals are lacking, and CBD supplementation in livestock is not approved. If CBD supplements can be shown to be safe and effective, detection in the animal will be important for determining regulation of use. A withdrawal period can then be established to allow time for deterioration of product to safe levels before livestock products enter human markets. This study sought to ...


Wastewater-Informed Public Health Intervention Playbook, 2022 University of Louisville

Wastewater-Informed Public Health Intervention Playbook

Sustain Magazine

As the SARS-CoV-2 pandemic quickly spread from country to country and continent to continent in 2020, governments and scientists needed a way to track COVID-19 through populations in order to position public health interventions in the most impactful locations. Having a decision-based risk framework may help to guide policy creation that could minimize or prevent possible outbreaks and surges of infection within communities. The University of Louisville in partnership with Louisville’s Department of Public Health and Wellness tested this strategy in 2021 and 2022. This Wastewater-Informed Public Health Intervention Playbook describes the decisions and actions of that academic and ...


An Interdisciplinary Discussion On Climate Change, Aamira Shah, Jaley F. Adkins, Kelsey Littrell, Priyadarshini Chandrashekhar 2022 University of Louisville

An Interdisciplinary Discussion On Climate Change, Aamira Shah, Jaley F. Adkins, Kelsey Littrell, Priyadarshini Chandrashekhar

The Cardinal Edge

No abstract provided.


Associations Between Cannabis, Psychosis, And Schizophrenia In Adolescents, Lauren Moment 2022 University of Colorado - Denver

Associations Between Cannabis, Psychosis, And Schizophrenia In Adolescents, Lauren Moment

Academic Leadership Journal in Student Research

The effects of cannabis use on the brain, mind, and body have been studied for decades. The developing brain, particularly the adolescent and young adult brain, undergoes critical development that makes it especially susceptible to the effects of cannabis use. Among the adverse effects of cannabis use in adolescence and young adulthood, psychosis and psychotic disorders (e.g., schizophrenia) have been examined. The association of cannabis use with schizophrenia was first elucidated in a Swedish study of army conscripts. Specifically, conscripts reported their cannabis use exposure and were followed longitudinally to assess the emergence of schizophrenia. The authors found that ...


In Silico Screening Of Violacein As An Epidermal Growth Factor Receptor Inhibitor, Smitha S Bhat, Sindhu R, Shashanka K Prasad 2022 Department of Biotechnology and Bioinformatics, JSS Academy of Higher Education and Research, Mysore

In Silico Screening Of Violacein As An Epidermal Growth Factor Receptor Inhibitor, Smitha S Bhat, Sindhu R, Shashanka K Prasad

International Journal of Health and Allied Sciences

EGFR is a key player in the signalling cascades of various kinds of cancers and tyrosine kinase inhibitors block EGFR signalling. Natural products have long been used as candidates for therapy in the management of cancer. Violacein, a bacterial pigment, has been known for its numerous biological applications such as antimicrobial, antileishmanial, antiviral, as well as antitumoral. Computational studies have concluded that it may have activity against cancers like pancreatic cancer, thyroid cancer, colorectal cancer, and endometrial cancer indicating its potential application as a broad range of anti-cancerous drug. This study aimed to perform the molecular docking of violacein with ...


Understanding The Status Of Important Criteria Air Pollutants And Its Health Effects – A Review, Christeena Varghese, Lingaraju H G, Shankramma Kalikeri 2022 Department of Environmental Science, School of Natural science, JSS Academy of Higher Education and Research Sri Shivarathreeshwara Nagara, Mysuru – 570 015 Karnataka, India

Understanding The Status Of Important Criteria Air Pollutants And Its Health Effects – A Review, Christeena Varghese, Lingaraju H G, Shankramma Kalikeri

International Journal of Health and Allied Sciences

In India, airborne pollutant is serious, and a growing illness cause of concern, adding considerably to the country's disease burden. Atmospheric effects are generally known to have several harmful health implications. India's air pollution has risen significantly because of population expansion, rising vehicle numbers, fuel usage, inefficient transit networks, poor land use patterns, industrialisation, and most importantly, insufficient environmental legislation. Because air pollution is a major factor, this has an impact on human health. People gradually understood that contaminated outdoor air had detrimental consequences on human health. Hypercholesterolemia, breathing problems, chronic obstructive pulmonary disease (COPD), and asthma are ...


Diallyl Disulfide Inhibits Proliferation, Epithelial—Mesenchymal Transition, And Invasion Through Rorα-Mediated Downregulation Of Wnt1/Β-Catenin Pathway In Gastric Cancer Cells, Jian Su, Hui He, Yu-Kun Li, Hong Xia, Fang Liu, Ying Zeng, Xi Zeng, Hui Ling, Bo Su, Qi Su 2022 Department of Pathology, Second Affiliated Hospital, University of South China, China

Diallyl Disulfide Inhibits Proliferation, Epithelial—Mesenchymal Transition, And Invasion Through Rorα-Mediated Downregulation Of Wnt1/Β-Catenin Pathway In Gastric Cancer Cells, Jian Su, Hui He, Yu-Kun Li, Hong Xia, Fang Liu, Ying Zeng, Xi Zeng, Hui Ling, Bo Su, Qi Su

Journal of Food and Drug Analysis

Overactivation of Wnt/β-catenin pathway due to dysfunction of retinoid-related orphan receptor α (RORα) is related to cancer development and progression. Diallyl disulfide (DADS), an active component of garlic, has been reported in our previous study for upregulation of RORα expression in gastric cancer (GC) cells. It remains to be elucidated the role and mechanism of RORα in DADS against GC. This study revealed that DADS treatment resulted in reduced expression levels of Wnt1, β-catenin, TCF-4, intranuclear β-catenin and p-β-catenin in GC cells, concomitant with the compromised expression of β-catenin target genes (Axin, c-Jun, and c-Myc). RORα overexpression augmented DADS-induced ...


Melatonin Exerts Anti-Fibrinolytic Effects By Regulating Il-1Β-Induced Changes In Upa, Upar, And Pai-1 Expression/Production In Human Dental Pulp Cells, Mei-Chi Chang, Bor-Hao Zhong, Hui-Na Lee, Fu-Hsiung Chuang, Ming-Shu Lee, Hsiao-Hua Chang, Yu-Hwa Pan, Jiiang-Huei Jeng 2022 Biomedical Science Team, Chang Gung University of Science and Technology, Kwei-Shan, Taoyuan City, Taiwan

Melatonin Exerts Anti-Fibrinolytic Effects By Regulating Il-1Β-Induced Changes In Upa, Upar, And Pai-1 Expression/Production In Human Dental Pulp Cells, Mei-Chi Chang, Bor-Hao Zhong, Hui-Na Lee, Fu-Hsiung Chuang, Ming-Shu Lee, Hsiao-Hua Chang, Yu-Hwa Pan, Jiiang-Huei Jeng

Journal of Food and Drug Analysis

Interleukin-1b (IL-1β) is a pro-inflammatory cytokine and its expression is increased in inflamed dental pulp. IL-1β affects plasminogen activation system molecules, which are crucial for tissue inflammation, fibrinolysis, matrix turnover, and cell adhesion and migration. Melatonin, which provides circadian and seasonal signals, is a physiological endocrine generated by the pineal gland. It has anti-oxidant and anti-inflammatory properties. Studies are warranted to determine whether melatonin prevents IL-1β-induced expression/production of plasminogen system molecules. Human dental pulp cells (HDPCs) were exposed to IL-1β or melatonin alone or to IL-1β with/without pretreatment with melatonin or other inhibitors. The mRNA expression of uPA ...


Stress Amelioration And Anti-Inflammatory Potential Of Shiikuwasha (Citrus Depressa Hayata) Essential Oil, Limonene, And Γ-Terpinene, Yonathan Asikin, Kuniyoshi Shimizu, Hironori Iwasaki, Hirosuke Oku, Koji Wada 2022 Department of Bioscience and Biotechnology, Faculty of Agriculture, University of the Ryukyus, Japan

Stress Amelioration And Anti-Inflammatory Potential Of Shiikuwasha (Citrus Depressa Hayata) Essential Oil, Limonene, And Γ-Terpinene, Yonathan Asikin, Kuniyoshi Shimizu, Hironori Iwasaki, Hirosuke Oku, Koji Wada

Journal of Food and Drug Analysis

Shiikuwasha (Citrus depressa Hayata) essential oil (SEO) extracted from Shiikuwasha fruit pulp contains two major volatile components, limonene and γ-terpinene (56.56–57.31 and 24.41–24.98%, respectively). In this study, we showed that the aroma streams of SEO, limonene, and γ-terpinene exhibited significant physiological stress amelioration effects in nine healthy female panelists tested in a 30-min visual display task. While SEO administration significantly reduced work errors by 15 min compared to the odorless control condition, the limonene stream reduced work errors only at the first and fourth 5-min intervals, and the γ-terpinene effect lasted only for the ...


Composition Decipherment Of Ficus Pumila Var. Awkeotsang And Its Potential On Covid-19 Symptom Amelioration And In Silico Prediction Of Sars-Cov-2 Interference., Hao-Chun Hu, Szu-Yin Yu, Xiao-Shan Hung, Chun-Han Su, Yu-Liang Yang, Chien-Kei Wei, Yuan-Bin Cheng, Yang-Chang Wu, Chia-Hung Yen, Tsong-Long Hwang, Shu-Li Chen, István Szatmári, Attila Hunyadi, Yi-Hong Tsai, Fang-Rong Chang 2022 Graduate Institute of Natural Products, College of Pharmacy, Kaohsiung Medical University, Taiwan

Composition Decipherment Of Ficus Pumila Var. Awkeotsang And Its Potential On Covid-19 Symptom Amelioration And In Silico Prediction Of Sars-Cov-2 Interference., Hao-Chun Hu, Szu-Yin Yu, Xiao-Shan Hung, Chun-Han Su, Yu-Liang Yang, Chien-Kei Wei, Yuan-Bin Cheng, Yang-Chang Wu, Chia-Hung Yen, Tsong-Long Hwang, Shu-Li Chen, István Szatmári, Attila Hunyadi, Yi-Hong Tsai, Fang-Rong Chang

Journal of Food and Drug Analysis

The jelly from achenes of Ficus pumila var. awkeotsang (FPAA) is a famous beverage ingredient in Taiwan. In this work, ficumarin (1), a new compound was obtained from its twigs (FPAT) and elucidated with comprehensive spectroscopic data. The biosynthetic origin was proposed from the p‐coumaroyl‐CoA pathway. Alloxanthoxyletin, betulinic acid, and catechin were identified as the major and active constituents responsible for relieving neutrophilic inflammation by FPAT. Among them, the most potent alloxanthoxyletin was found to interact with PRO350 and GLU377 of human INOSOX. Further, Nrf2 activating capacity of the FPAT fraction and its coumarins was confirmed. With the ...


Phytochemical Characterization, Antioxidant Potential, And Health Risk Assessment Of Radix Oryzae Glutinosae, Hai-Ping Liu, Jian-Feng Tang, Kai Ren, Tong-Jun Chen, Ping-Ping Zhu, Dong-Dong Sun, Wei-Yun Wang 2022 School of ife Sciences, Anhui Agricultural University, China

Phytochemical Characterization, Antioxidant Potential, And Health Risk Assessment Of Radix Oryzae Glutinosae, Hai-Ping Liu, Jian-Feng Tang, Kai Ren, Tong-Jun Chen, Ping-Ping Zhu, Dong-Dong Sun, Wei-Yun Wang

Journal of Food and Drug Analysis

Radix Oryzae Glutinosae (ROG) has been used as a traditional anhidrotic agent in China. Ten samples were systematically assessed based on four aspects of their chemical profiles and antioxidant activity. The former was achieved using ultraviolet-visible spectra (UV), infrared absorption spectra (IR), proton nuclear magnetic resonance spectroscopy (1H NMR), and inductively coupled plasma-mass spectrometry (ICP-MS) fingerprints, and antioxidant activity was assessed using the 1,1-diphenyl-2-picrylhydrazyl (DPPH) assay, the 2,2′-azino-bis-(3-ethylbenzothiazoline-6-sulfonic acid) diammonium salt (ABTS) assay, and the ferric reducing antioxidant power (FRAP) assay. The presence of amino acids, flavonoids, organic acids, and sugars was indicated in all ...


Systems Pharmacology Dissection Of The Mechanisms And Therapeutic Potential Of Cassiae Semen For Hepatoprotection And Brightening Eyes, Jing-Xiao Zhang, Zi-Yi Chen, Xue-Zhen Huang, Lin-Yue Qi, Wei Zhou 2022 School of Food and Drug, Luoyang Normal University, China

Systems Pharmacology Dissection Of The Mechanisms And Therapeutic Potential Of Cassiae Semen For Hepatoprotection And Brightening Eyes, Jing-Xiao Zhang, Zi-Yi Chen, Xue-Zhen Huang, Lin-Yue Qi, Wei Zhou

Journal of Food and Drug Analysis

Cassiae semen has been shown to play significant roles in reversing “liver fire” to improve vision. The systems mechanism of Cassiae semen for hepatoprotection and brightening eyes has not been fully explored. The systems pharmacology approach is proposed to dissect the potential pharmacological mechanism of Cassiae semen for hepatoprotection and brightening eyes. The results showed that 26 active components of Cassiae semen that connected with 230 targets were obtained. Gene ontology enrichment, network and pathway analysis explored that Cassiae semen is responsible for hepatoprotection and brightening eyes. The current study will contribute to the research and development of functional foods.


Exploring The Relationship Between Metabolite Composition And The Cold/Hot Properties Ascribed In Traditional Chinese Medicine By Mass Spectral Molecular Networking–A Pilot Study, Chun-Han Su, Yu-Chieh Cheng, Kuei-Hung Lai, Yu-Chia Chang, Chi-Hui Sun, Po-Wen Tu, Ching-Chih Lin, Tsong-Long Hwang, Yu-Liang Yang 2022 Agricultural Biotechnology Research Center, Academia Sinica, Taiwan

Exploring The Relationship Between Metabolite Composition And The Cold/Hot Properties Ascribed In Traditional Chinese Medicine By Mass Spectral Molecular Networking–A Pilot Study, Chun-Han Su, Yu-Chieh Cheng, Kuei-Hung Lai, Yu-Chia Chang, Chi-Hui Sun, Po-Wen Tu, Ching-Chih Lin, Tsong-Long Hwang, Yu-Liang Yang

Journal of Food and Drug Analysis

Traditional Chinese medicine (TCM) has been applied to improve human health for millennia. In the TCM system, “medicinal property” (yao xing; hot and cold properties) is a core concept used to describe the influences of medicinal materials on human physiological conditions, and metabolites are believed to be one of the major ingredients of TCMs that affect their medicinal property. However, due to a lack of comprehensive analyses of TCM metabolomes, information about the relationships between TCM metabolite composition and medicinal property remains limited. In this pilot study, a mass spectral molecular networking-based platform was established and applied to systematically profile ...


Quantification Of Anthocyanosides In Grapes By Quechers And Biphenyl-Uhplc Tandem Mass Spectrometry, Lun-Chi Yang, Sung-Fang Chen 2022 Department of Chemistry, National Taiwan Normal University, Taiwan

Quantification Of Anthocyanosides In Grapes By Quechers And Biphenyl-Uhplc Tandem Mass Spectrometry, Lun-Chi Yang, Sung-Fang Chen

Journal of Food and Drug Analysis

In this study, the QuEChERS and UHPLC-MS/MS method using a biphenyl stationary phase was developed and applied for the rapid separation of 12 anthocyanosides in grapes. Efficient separation was achieved for a wide range of mono- and un-glycosylated anthocyanosides. The linear ranges of the target anthocyanosides were 0.5 to 500 ng mL−1. The intra- and inter-day precisions were both below 11.8%. Anthocyanosides in grapes from different sources were successfully quantified. Thus, the developed QuEChERS and UHPLC-MS/MS method provide an attractive alternative for the quantification of anthocyanosides in grapes.


Fluorescence Detection Of Malachite Green In Fish Based On Aptamer And Sybr Green I, Jia Wang, Chengyi Hong, Zhengzhong Lin, Zhi-Yong Huang 2022 College of Ocean Food and Biological Engineering, Jimei University, China

Fluorescence Detection Of Malachite Green In Fish Based On Aptamer And Sybr Green I, Jia Wang, Chengyi Hong, Zhengzhong Lin, Zhi-Yong Huang

Journal of Food and Drug Analysis

A simple fluorescence method to quantitatively monitor malachite green (MG) was introduced based on the conformation switch effect of MG-aptamer (Apt) and the fluorochrome of SYBR Green I (SGI). SGI can embed in the stem–loop structure of Apt to produce fluorescence. However, the fluorescence will be quenched when MG is introduced because of the specific binding of Apt to MG. Under the optimal conditions, the fluorescence method displayed excellent linear relationship between the fluorescence quenching efficiencies and the MG concentrations ranging from 0.02 μmol L−1 to 1.0 μmol L−1. The detection limit of the method ...


Bromelain Activates The Amp-Activated Protein Kinase-Autophagy Pathway To Alleviate Hepatic Lipid Accumulation, Po-An Hu, Man-Chen Hsu, Szu-Han Chen, Chia-Hui Chen, Yu Ru Kou, Jenq-Wen Huang, Tzong-Shyuan Lee 2022 Graduate Institute and Department of Physiology, College of Medicine, National Taiwan University, Taipei, Taiwan

Bromelain Activates The Amp-Activated Protein Kinase-Autophagy Pathway To Alleviate Hepatic Lipid Accumulation, Po-An Hu, Man-Chen Hsu, Szu-Han Chen, Chia-Hui Chen, Yu Ru Kou, Jenq-Wen Huang, Tzong-Shyuan Lee

Journal of Food and Drug Analysis

Bromelain, a cysteine protease found in pineapple, is known to exert protective effects against non-alcoholic fatty liver disease (NAFLD); however, the underlying mechanism is unclear. In this study, we aimed to investigate the molecular mechanisms underlying the beneficial effects of bromelain using in vivo and in vitro models. C57BL/6 mice were fed a high-fat diet (HFD) with or without bromelain (20 mg/kg/day) for 12 weeks. We found that treatment with bromelain alleviated hepatic lipid accumulation accompanied by the activation of AMP-activated protein kinase (AMPK) and autophagy flux, as evidenced by the elevated levels of phosphorylated AMPK, ATG5 ...


Metabolism-Involved Drug Interactions With Traditional Chinese Medicines In Cardiovascular Diseases, Ren-Jong Liang, Shu-Hao Hsu, Tien-Yu Chang, Tzu-Yi Chiang, Hong-Jaan Wang, Yune-Fang Ueng 2022 Medical Supplies and Maintenance, Hualien Armed Forces General Hospital, Taiwan

Metabolism-Involved Drug Interactions With Traditional Chinese Medicines In Cardiovascular Diseases, Ren-Jong Liang, Shu-Hao Hsu, Tien-Yu Chang, Tzu-Yi Chiang, Hong-Jaan Wang, Yune-Fang Ueng

Journal of Food and Drug Analysis

Herbal medicines have been widely used for the past millennia. Traditional Chinese medicine (TCM) is a major modality in Chinese medical care and has garnered global attention owing to its pharmacological effects and multi-targeted actions. The increased incidence of sequential or concurrent use of herbs and drugs in patients forces us to consider herb-drug interactions (HDIs) in this modern era. One of the main causes of HDIs is modulation of drug metabolism, in which cytochrome P450 (CYP), UDP-glucuronosyltransferase (UGT), and transporters play primary roles. In this review, we focus on in vivo studies of HDIs, particularly in the treatment of ...


Real-World Evidence Of The Herb-Drug Interactions, Hsueh-Yi Pan, Li-Wei Wu, Pin-Chun Wang, Ping-Hung Chiu, Meng-Ting Wang 2022 Department of Pharmacy, National Yang Ming Chiao Tung University, Taiwan

Real-World Evidence Of The Herb-Drug Interactions, Hsueh-Yi Pan, Li-Wei Wu, Pin-Chun Wang, Ping-Hung Chiu, Meng-Ting Wang

Journal of Food and Drug Analysis

Herbal medicine (HM) is a type of medicine that uses active ingredients made from plants to treat diseases and maintain health and wellbeing. Due to its increasing worldwide usage, the possibility of HMs and conventional drugs being concurrently used is high, potentially leading to adverse events resulting from herb-drug interactions. Despite the safety concerns regarding such interactions, few studies have been conducted for assessing clinical consequences of using HMs with conventional drugs in real-world settings. As clinical trials are not forthcoming rapidly enough to provide the evidence for herb-drug interactions, observational studies are considered as an alternative approach. The present ...


Expulsive Greening: A Cross-Sectional Analysis Of Green Gentrification In The Resilience Paradigm, Brooklyn 2010–2020, Rose Jimenez 2022 The Graduate Center, City University of New York

Expulsive Greening: A Cross-Sectional Analysis Of Green Gentrification In The Resilience Paradigm, Brooklyn 2010–2020, Rose Jimenez

Dissertations, Theses, and Capstone Projects

Background: This project analyzes the spatial coincidence between gentrification typologies and urban greening in Brooklyn, New York from 2010 to 2020. Assets formed under the NYC Green Infrastructure Program were chosen as a proxy for urban greening to represent the spatial practice specifically within the 21st-century climate change resilience paradigm of development. Methods: First, five indexes measuring variations of economic and demographic conditions related to gentrification were applied to Brooklyn for comparative analysis: NOAA’s Social Vulnerability Indicators of Gentrification Pressure, The NYC Heat Vulnerability Index, The Small Area Index of Gentrification, Typologies of Gentrification and Displacement, and The Housing ...


Novel Therapeutic Strategies For Alzheimer’S Disease: Prostaglandin D2 Signaling And Its Human Polymorphisms As Well As A Polypharmacological Approach, Charles H. Wallace 2022 The Graduate Center, City University of New York

Novel Therapeutic Strategies For Alzheimer’S Disease: Prostaglandin D2 Signaling And Its Human Polymorphisms As Well As A Polypharmacological Approach, Charles H. Wallace

Dissertations, Theses, and Capstone Projects

Alzheimer’s disease (AD) is an age related neurodegenerative disease with pathology that includes amyloid plaques, neurofibrillary tangles and non-resolving neuroinflammation. Non-resolving neuroinflammation lasts the entire course of the disease and has deleterious effects and is often thought to accelerate AD pathology. Non-Steroidal Anti-inflammatory Drugs (NSAIDs) have commonly been used as therapeutics to treat pain, inflammation and vascular. NSAIDs work by altering the cyclooxygenase (COX) mediated biosynthesis of prostaglandins which are lipid mediators that have many physiological functions, for example nociception, inflammation and vasodilation. Epidemiological studies support the notion that NSAIDs could be used to treat AD. Yet, clinical trials ...


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