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Underlying Contribution Of Executive Functioning To Cognition And Academic Achievement In Individuals With Dystrophinopathy, Robert Fee 2018 The Graduate Center, City University of New York

Underlying Contribution Of Executive Functioning To Cognition And Academic Achievement In Individuals With Dystrophinopathy, Robert Fee

All Dissertations, Theses, and Capstone Projects

Dystrophinopathy is a genetic disorder that results in the lack of or abnormal expression of the protein dystrophin. It is a disorder that alters cell structure and function, impacts the developing brain and brain function, presents with multi-domain cognitive deficits, and influences both mood and behavior. Cognitive impairments appear to be more localized to specific areas of functioning rather than a global deficit; however, deficits have been identified across multiple cognitive domains including language and aspects of executive functioning. A careful examination of the cognitive phenotype and its association to mutations affecting CNS isoforms is necessary to clarify the neuropsychological ...


Regulation Of Epithelial Sodium Channels In Vasopressin Neurons In The Hypothalamus, Natalie Jean Mills 2018 Louisiana State University

Regulation Of Epithelial Sodium Channels In Vasopressin Neurons In The Hypothalamus, Natalie Jean Mills

LSU Doctoral Dissertations

Salt-sensitive individuals have blood pressure that is unusually sensitive to salt intake. Because salt-sensitivity is a common disorder and may cause high blood pressure, it is a significant public health concern. All three epithelial Na+ channel (ENaC) subunits (a, b, and g) and the mineralocorticoid receptor (MR), a known regulator of ENaC, are expressed by vasopressin (VP) synthesizing magnocellular neurons in the hypothalamic supraoptic (SON) and paraventricular (PVN) nuclei. A growing body of evidence indicates that epithelial Na+ channels (ENaCs) in the hypothalamus play a significant role in the development of salt-sensitivity. My dissertation research tests the hypothesis that abnormal ...


Chemosensory Communication And Neural Substrates Of Social Behavior In The African Cichlid Fish, Astatotilapia Burtoni, Karen Elizabeth Field 2018 Louisiana State University

Chemosensory Communication And Neural Substrates Of Social Behavior In The African Cichlid Fish, Astatotilapia Burtoni, Karen Elizabeth Field

LSU Doctoral Dissertations

Social animals must constantly assess their environment to make appropriate decisions. In several fish species, chemosensory signaling is crucial for social communication, conveying information on sex, reproductive state, and social status. Despite its importance in fishes, relatively little is known about how they employ chemical signaling, with only a few of the over 30,000 extant species investigated thus far. Further, there is a scarcity of information about where and how socially-relevant chemosensory signals are processed in the brain of fishes, or how chemosensory signals are integrated with other senses to elicit appropriate behaviors. For my doctoral research, I examined ...


Endocytosis And The Nitric Oxide-Dependent Release Of Chloride, Vernon K. Dunn Jr 2018 Louisiana State University and Agricultural and Mechanical College

Endocytosis And The Nitric Oxide-Dependent Release Of Chloride, Vernon K. Dunn Jr

LSU Doctoral Dissertations

Understanding the regulation of retinal synapses is a key step in elucidating the processing of information in the retina. Our lab has previously shown that nitric oxide (NO) can alter the synaptic response properties of amacrine cells by releasing Cl- from internal acidic compartments. This alteration in the Cl- gradient brings about a positive shift in the reversal potential of the GABA-gated current, which can convert inhibitory synapses into excitatory synapses. Recently, we have shown that the cystic fibrosis transmembrane regulator (CFTR) Cl- channel is involved in the Cl- release. Here, we test the hypothesis that (acidic) synaptic vesicles are ...


Nuclear Export Through Nuclear Envelope Remodeling In Saccharomyces Cerevisiae, Baojin Ding, Anne M. Mirza, James A. Ashley, Vivian Budnik, Mary Munson 2018 University of Massachusetts Medical School

Nuclear Export Through Nuclear Envelope Remodeling In Saccharomyces Cerevisiae, Baojin Ding, Anne M. Mirza, James A. Ashley, Vivian Budnik, Mary Munson

University of Massachusetts Medical School Faculty Publications

In eukaryotes, subsets of exported mRNAs are organized into large ribonucleoprotein (megaRNP) granules. How megaRNPs exit the nucleus is unclear, as their diameters are much larger than the nuclear pore complex (NPC) central channel. We previously identified a non-canonical nuclear export mechanism in Drosophila (Speese et al., Cell 2012) and mammals (Ding et al., in preparation), in which megaRNPs exit the nucleus by budding across nuclear envelope (NE) membranes. Here, we present evidence for a similar pathway in the nucleus of the budding yeast S. cerevisiae, which contain morphologically similar granules bearing mRNAs. Wild-type yeast displayed these granules at very ...


A Rationally Engineered Capsid Variant Of Aav9 For Systemic Cns-Directed And Peripheral Tissue-Detargeted Gene Delivery In Neonates, Dan Wang, Shaoyong Li, Dominic J. Gessler, Jun Xie, Li Zhong, Jia Li, Karen Tran, Kim Van Vliet, Lingzhi Ren, Qin Su, Ran He, Jason E. Goetzmann, Terence R. Flotte, Mavis Agbandje-McKenna, Guangping Gao 2018 University of Massachusetts Medical School

A Rationally Engineered Capsid Variant Of Aav9 For Systemic Cns-Directed And Peripheral Tissue-Detargeted Gene Delivery In Neonates, Dan Wang, Shaoyong Li, Dominic J. Gessler, Jun Xie, Li Zhong, Jia Li, Karen Tran, Kim Van Vliet, Lingzhi Ren, Qin Su, Ran He, Jason E. Goetzmann, Terence R. Flotte, Mavis Agbandje-Mckenna, Guangping Gao

Open Access Articles

Adeno-associated virus (AAV) has provided the gene therapy field with the most powerful in vivo gene delivery vector to realize safe, efficacious, and sustainable therapeutic gene expression. Because many clinically relevant properties of AAV-based vectors are governed by the capsid, much research effort has been devoted to the development of AAV capsids for desired features. Here, we combine AAV capsid discovery from nature and rational engineering to report an AAV9 capsid variant, designated as AAV9.HR, which retains AAV9's capability to traverse the blood-brain barrier and transduce neurons. This variant shows reduced transduction in peripheral tissues when delivered through ...


Mapping Molecular Datasets Back To The Brain Regions They Are Extracted From: Remembering The Native Countries Of Hypothalamic Expatriates And Refugees, Arshad M. Khan, Alice H. Grant, Anais Martinez, Gully APC Burns, Brendan S. Thatcher, Vishwanath T. Anekonda, Benjamin W. Thompson, Zachary S. Roberts, Daniel H. Moralejo, James E. Blevins 2018 University of Texas at El Paso

Mapping Molecular Datasets Back To The Brain Regions They Are Extracted From: Remembering The Native Countries Of Hypothalamic Expatriates And Refugees, Arshad M. Khan, Alice H. Grant, Anais Martinez, Gully Apc Burns, Brendan S. Thatcher, Vishwanath T. Anekonda, Benjamin W. Thompson, Zachary S. Roberts, Daniel H. Moralejo, James E. Blevins

Arshad M. Khan, Ph.D.

This article, which includes novel unpublished data along with commentary and analysis,
focuses on approaches to link transcriptomic, proteomic, and peptidomic datasets mined from
brain tissue to the original locations within the brain that they are derived from using digital atlas
mapping techniques. We use, as an example, the transcriptomic, proteomic and peptidomic
analyses conducted in the mammalian hypothalamus. Following a brief historical overview, we
highlight studies that have mined biochemical and molecular information from the hypothalamus
and then lay out a strategy for how these data can be linked spatially to the mapped locations in a
canonical brain atlas ...


Processing Emotional Expression In The Dance Of A Foreign Culture: Gestural Responses Of Germans And Koreans To Ballet And Korean Dance, Zi Hyun Kim, Hedda Lausberg 2018 German Sport University Cologne

Processing Emotional Expression In The Dance Of A Foreign Culture: Gestural Responses Of Germans And Koreans To Ballet And Korean Dance, Zi Hyun Kim, Hedda Lausberg

Journal of Movement Arts Literacy

Artistic dance differs between cultures with regard to the formal movement repertoire and methods to represent dancer's emotions. The present study explores how differently the spectators perceive the dance scenes of their own and foreign cultures. We showed German and Korean participants sad and happy dance scenes of the French ballet Giselle and Korean dance Sung-Mu. To learn the perceived thoughts and feelings of the participant from the dance scenes, we analyzed the frequency of their hand movements and gestures, which were accompanied by verbal descriptions of the participant's appreciation immediately after observation of the dance stimuli. The ...


Social Experience Affects Decision Making And Learning: Empirical And Computational Analysis, Sungwoo Ahn 2018 East Carolina University

Social Experience Affects Decision Making And Learning: Empirical And Computational Analysis, Sungwoo Ahn

Biology and Medicine Through Mathematics Conference

No abstract provided.


Ephrinb3 Modulates Hippocampal Neurogenesis And The Reelin Signaling Pathway In A Pilocarpineinduced Model Of Epilepsy, Tian-Tian Liu, Yi Li, Yi Shu, Bo Xiao, Li Feng 2018 Central South University

Ephrinb3 Modulates Hippocampal Neurogenesis And The Reelin Signaling Pathway In A Pilocarpineinduced Model Of Epilepsy, Tian-Tian Liu, Yi Li, Yi Shu, Bo Xiao, Li Feng

Open Access Articles

EphrinB3 is important in the regulation of cell proliferation, differentiation and migration via cellcell contact, and can activate the reelin pathway during brain development. However, the effect of ephrinB3 on hippocampal neurogenesis and the reelin pathway in epilepsy remains to be fully elucidated. In the present study, the expression of ephrinB3 in pilocarpineinduced status epilepticus (SE) rats was investigated. SYBR Greenbased reverse transcriptionquantitative polymerase chain reaction analysis, immunohistochemical labeling and western blot analysis were used to detect the gene and protein expression levels of ephrinB3 and reelin pathway proteins. Immunofluorescence staining of doublecortin (DCX) was utilized to analyze hippocampal neurogenesis ...


Defining The Radioresponse Of Mossy Cells, Devon Ivy 2018 California State University, San Bernardino

Defining The Radioresponse Of Mossy Cells, Devon Ivy

Electronic Theses, Projects, and Dissertations

Clinical radiotherapy is used to treat a variety of brain tumors within the central nervous system. While effective, it can result in progressive and debilitating cognitive impairment that can diminish quality of life. These impairments have been linked to hippocampal dysfunction and corresponding deficits in spatial learning and memory. Mossy cells are a major population of excitatory neurons located within the dentate hilus and highly involved in hippocampal circuitry. They play critical roles in spatial navigation, neurogenesis, memory, and are particularly vulnerable to a variety of neurotoxic insults. However, their sensitivity to ionizing radiation has yet to be investigated in ...


Reflections On Contributing To “Big Discoveries” About The Fly Clock: Our Fortunate Paths As Post-Docs With 2017 Nobel Laureates Jeff Hall, Michael Rosbash, And Mike Young, Kathleen King Siwicki, P. E. Hardin, J. L. Price 2018 Swarthmore College

Reflections On Contributing To “Big Discoveries” About The Fly Clock: Our Fortunate Paths As Post-Docs With 2017 Nobel Laureates Jeff Hall, Michael Rosbash, And Mike Young, Kathleen King Siwicki, P. E. Hardin, J. L. Price

Biology Faculty Works

In the early 1980s Jeff Hall and Michael Rosbash at Brandeis University and Mike Young at Rockefeller University set out to isolate the period (per) gene, which was recovered in a revolutionary genetic screen by Ron Konopka and Seymour Benzer for mutants that altered circadian behavioral rhythms. Over the next 15 years the Hall, Rosbash and Young labs made a series of groundbreaking discoveries that defined the molecular timekeeping mechanism and formed the basis for them being awarded the 2017 Nobel Prize in Physiology or Medicine. Here the authors recount their experiences as post-docs in the Hall, Rosbash and Young ...


Self-Regulation, Threat Perception, And Inhibitory Control: An Fmri Investigation Of Children With Adhd, Erin Kaseda 2018 Brigham Young University

Self-Regulation, Threat Perception, And Inhibitory Control: An Fmri Investigation Of Children With Adhd, Erin Kaseda

Undergraduate Honors Theses

This thesis examines the role of perceived parental support on adolescents aged 12-19 who have been diagnosed with attention-deficit/hyperactivity disorder (ADHD). Specifically, the study focused on inhibitory control, one form of cognitive executive control often implicated in ADHD, in three ways: first, through the use of a Go/No-Go task during a functional MRI scan of the brain; second, through the use of a neuropsychological cognitive battery using the NIH Toolbox; and third, through a qualitative interview that examined self-control in school and home contexts. Contrary to the initial hypothesis, parental support was found to be negatively correlated with ...


Geometric Analysis Of Synchronization In Neuronal Networks With Global Inhibition And Coupling Delays, Hwayeon Ryu, Sue Ann Campbell 2018 University of Hartford

Geometric Analysis Of Synchronization In Neuronal Networks With Global Inhibition And Coupling Delays, Hwayeon Ryu, Sue Ann Campbell

Biology and Medicine Through Mathematics Conference

No abstract provided.


Examining Motor Unit Stability Of First Dorsal Interosseous (Fdi) And Biceps Brachii (Bb) Muscles In Healthy And Older Adults Using Decomposition-Based Quantitative Electromyography (Dqemg), Igor Angelovski 2018 The University of Western Ontario

Examining Motor Unit Stability Of First Dorsal Interosseous (Fdi) And Biceps Brachii (Bb) Muscles In Healthy And Older Adults Using Decomposition-Based Quantitative Electromyography (Dqemg), Igor Angelovski

Electronic Thesis and Dissertation Repository

Aging of the human neuromuscular system is associated with gradual decline in motor unit (MU) number leading to denervation of muscle fibers and subsequent compensatory reinnervation from surviving MUs. Lower limb muscles exhibit age-related increased MU instability (measured electrophysiologically), however not much is known regarding MU stability of aging upper limb muscles. The purpose of this study was to examine agerelated MU loss in upper limb muscles (first dorsal interosseous [FDI] and biceps brachii [BB]) and the impact on MU stability in younger and older healthy subjects using electrophysiological near fiber analysis from decomposition-based quantitative electromyography (DQEMG). FDI and BB ...


Effect Sizes In Task-Based Functional Magnetic Resonance Imaging, Tyler Kellett 2018 Augustana College, Rock Island Illinois

Effect Sizes In Task-Based Functional Magnetic Resonance Imaging, Tyler Kellett

Celebration of Learning

Task-based functional magnetic resonance imaging (t-fMRI) techniques have changed the way scientists probe the neurological mechanisms underlying behavior. However, there are many problems surrounding t-fMRI especially underpowered studies leading to misleading effect sizes. This study is using a recent large data collection study, the Human Connectome Project, to investigate effect sizes in specific regions of the brain involving working memory. Previous studies have come up with relatively small effect sizes due to small sample sizes and large regions of interest (ROI). This study is concentrated on using more precise ROI called parcels to find larger effect sizes.


An Investigation Of The Cortical Learning Algorithm, Anthony C. Samaritano 2018 Rowan University

An Investigation Of The Cortical Learning Algorithm, Anthony C. Samaritano

Theses and Dissertations

Pattern recognition and machine learning fields have revolutionized countless industries and applications from biometric security to modern industrial assembly lines. The fields continue to accelerate as faster, more efficient processing hardware becomes commercially available. Despite the accelerated growth of the pattern recognition and machine learning fields, computers still are unable to learn, reason, and perform rudimentary tasks that humans and animals find routine. Animals are able to move fluidly, understand their environment, and maximize their chances of survival through adaptation - animals demonstrate intelligence. A primary argument in this thesis that we have not yet achieved a level of intelligence similar ...


Contextual Fear Retrieval-Induced Fos Expression Across Early Development In The Rat: An Analysis Using Established Nervous System Nomenclature Ontology, Anthony J. Santarelli, Arshad M. Khan, Andrew M. Poulos 2018 University at Albany, State University of New York

Contextual Fear Retrieval-Induced Fos Expression Across Early Development In The Rat: An Analysis Using Established Nervous System Nomenclature Ontology, Anthony J. Santarelli, Arshad M. Khan, Andrew M. Poulos

Arshad M. Khan, Ph.D.

No abstract provided.


‘Preferred’ Stimulus Of A Whole Model Visual System, Olivier Penacchio, Julie M. Harris 2018 University of St Andrews

‘Preferred’ Stimulus Of A Whole Model Visual System, Olivier Penacchio, Julie M. Harris

MODVIS Workshop

No abstract provided.


Finding Any Waldo: Zero-Shot Invariant And Efficient Visual Search, Gabriel Kreiman, Mengmi Zhang 2018 HMS

Finding Any Waldo: Zero-Shot Invariant And Efficient Visual Search, Gabriel Kreiman, Mengmi Zhang

MODVIS Workshop

Visual search constitutes a ubiquitous challenge in natural vision, including daily tasks such as finding a friend in a crowd or searching for a car in a parking lot. Visual search must fulfill four key properties: selectivity (to distinguish the target from distractors in a cluttered scene), invariance (to localize the target despite changes in its rotation, scale, illumination, and even searching for generic object categories), speed (to efficiently localize the target without exhaustive sampling), and generalization (to search for any object, even ones that we have had minimal or no experience with). Here we propose a computational model that ...


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