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Effects Of Gene Methylation On Behavior In Green Anole Lizards (Anolis Carolinensis), Krystal Archer 2014 Georgia State University

Effects Of Gene Methylation On Behavior In Green Anole Lizards (Anolis Carolinensis), Krystal Archer

Georgia State Undergraduate Research Conference

No abstract provided.


The Effects Of Picrotoxin And Ethanol On Crayfish Escape And Central Motor Pattern Neural Circuits, Rebecca Bierman, Nathan Hardcastle, Colin Istvan 2014 Georgia State University

The Effects Of Picrotoxin And Ethanol On Crayfish Escape And Central Motor Pattern Neural Circuits, Rebecca Bierman, Nathan Hardcastle, Colin Istvan

Georgia State Undergraduate Research Conference

No abstract provided.


The Effects Of Systemic Serotonin Depletion On Sexual Preference Of Male Syrian Hamsters, Samantha Bowden, Ashleigh Burns, Aras Petrulis 2014 Georgia State University

The Effects Of Systemic Serotonin Depletion On Sexual Preference Of Male Syrian Hamsters, Samantha Bowden, Ashleigh Burns, Aras Petrulis

Georgia State Undergraduate Research Conference

No abstract provided.


Age Differences In Bdnf Gene Expression After Cocaine Self-Administration Or Cue-Induced Reinstatement Of Cocaine-Seeking In Male Rats, Alexandria C. White 2014 Georgia State University

Age Differences In Bdnf Gene Expression After Cocaine Self-Administration Or Cue-Induced Reinstatement Of Cocaine-Seeking In Male Rats, Alexandria C. White

Georgia State Undergraduate Research Conference

No abstract provided.


Altering Cognitive And Brain States Through Cortical Entrainment, Nicholas P. Bello 2014 Georgia State University

Altering Cognitive And Brain States Through Cortical Entrainment, Nicholas P. Bello

Georgia State Undergraduate Research Conference

No abstract provided.


Mental Imagery For The Detection Of Awareness: Evaluating The Convergence Of Functional Magnetic Resonance Imaging And Electroencephalographic Assessments, Amabilis H. Harrison 2014 McMaster University

Mental Imagery For The Detection Of Awareness: Evaluating The Convergence Of Functional Magnetic Resonance Imaging And Electroencephalographic Assessments, Amabilis H. Harrison

Open Access Dissertations and Theses

The accurate diagnosis of disorders of consciousness presents substantial difficulty because of the reliance on behaviour-based assessment tools. A patient may be covertly aware but unable to indicate their state due to physical impairments. Neuroimaging researchers have begun to seek alternate methods of assessment that rely on brain responses rather than behavioural ones. To this end, mental imagery has been employed as a voluntary cognitive activity that can be measured with fMRI or EEG to indicate awareness. In this dissertation I examine the advantages and limitations of these two imaging techniques and argue that EEG is more suitable for this ...


Painful Disparities, Painful Realities, Amanda C. Pustilnik 2014 University of Maryland Francis King Carey School of Law

Painful Disparities, Painful Realities, Amanda C. Pustilnik

Faculty Scholarship

Legal doctrines and decisional norms treat chronic claims pain differently than other kinds of disability or damages claims because of bias and confusion about whether chronic pain is real. This is law’s painful disparity. Now, breakthrough neuroimaging can make pain visible, shedding light on these mysterious ills. Neuroimaging shows these conditions are, as sufferers have known all along, painfully real. This Article is about where law ought to change because of innovations in structural and functional imaging of the brain in pain. It describes cutting-edge scientific developments and the impact they should make on evidence law and disability law ...


Massively Parallel Nonparametric Regression, With An Application To Developmental Brain Mapping, Philip T. Reiss, Lei Huang, Yin-Hsiu Chen, Lan Huo, Thaddeus Tarpey, Maarten Mennes 2014 SelectedWorks

Massively Parallel Nonparametric Regression, With An Application To Developmental Brain Mapping, Philip T. Reiss, Lei Huang, Yin-Hsiu Chen, Lan Huo, Thaddeus Tarpey, Maarten Mennes

Philip T. Reiss

We propose a penalized spline approach to performing large numbers of parallel nonparametric analyses of either of two types: restricted likelihood ratio tests of a parametric regression model versus a general smooth alternative, and nonparametric regression. Compared with naively performing each analysis in turn, our techniques reduce computation time dramatically. Viewing the large collection of scatterplot smooths produced by our methods as functional data, we develop a clustering approach to summarize and visualize these results. Our approach is applicable to ultra-high-dimensional data, particularly data acquired by neuroimaging; we illustrate it with an analysis of developmental trajectories of functional connectivity at ...


Differential Effects Of Early-Life Seizures On Neuronal Inhibition In The Hippocampus Of Seizure-Prone And Seizure-Resistant Rats, Amir Abbas Mohseni Zonoozi 2014 Western University

Differential Effects Of Early-Life Seizures On Neuronal Inhibition In The Hippocampus Of Seizure-Prone And Seizure-Resistant Rats, Amir Abbas Mohseni Zonoozi

University of Western Ontario - Electronic Thesis and Dissertation Repository

The aim of this study is to investigate the long-term physiological consequences of early-life seizures in rats of different genetic backgrounds. Rats bred to be prone (Fast) or resistant (Slow) to amygdala kindling were induced with status epilepticus (SE) on postnatal day (PND) 10 by injecting 3 mg/kg i.p. kainic acid; SE consisted of seizures for 2 h, including stage 5 seizures (lying down with four limb tonic-clonic convulsions). Littermates injected with the same volume of saline i.p. served as controls. On PND 40-55, population spikes (PSs) were recorded at the CA1 pyramidal cell layer in hippocampal ...


Hippotherapy As A Tool For Improving Motor Skills, Postural Stability, And Self Confidence In Cerebral Palsy And Multiple Sclerosis, Sarah A. Long 2014 University of Puget Sound

Hippotherapy As A Tool For Improving Motor Skills, Postural Stability, And Self Confidence In Cerebral Palsy And Multiple Sclerosis, Sarah A. Long

Sound Neuroscience: An Undergraduate Neuroscience Journal

Hippotherapy utilizes the three dimensional movement of the horse to improve balance, strength, coordination, and postural symmetry in those with cerebral palsy, multiple sclerosis, or related neuromuscular disorders. The forward, side-to-side, and rotational movement of the horse provides the rider with different sensory cues to help improve gait. While this therapy is a passive exercise for the patient, the individual must engage the core muscles to sit upright along with making small corrections due to the constant movement of the horse to help with postural stability and strengthening. Ultimately, understanding how affected brain areas lead to symptoms in those with ...


Calpain 5: A Non-Classical Calpain Highly Expressed In The Cns And Localized To Mitochondria And Nuclear Pml Bodies, Ranjana Singh 2014 University of Kentucky

Calpain 5: A Non-Classical Calpain Highly Expressed In The Cns And Localized To Mitochondria And Nuclear Pml Bodies, Ranjana Singh

Theses and Dissertations--Anatomy and Neurobiology

Calpain 5 (CAPN5) is a non-classical member of the calpain family. It lacks the EF-hand motif characteristic of the classical calpains, calpain 1 and 2, but retains catalytic and Ca2+ binding non EF domains. Tra-3, an ortholog of CAPN5, is involved in necrotic cell death in C.elegans; although specific role of CAPN5 has not been investigated in the mammalian CNS. I compared relative mRNA levels of calpains in rat CNS, which revealed that CAPN5 is the second most highly expressed calpain. We examined relative levels of CAPN5 from late embryonic day 18 to postnatal day 90 and found ...


An In Vivo Assay For Simultaneous Monitoring Of Neuronal Activity And Behavioral Output In The Stomatogastric Nervous System Of Decapod Crustaceans, Wolfgang Stein, Florian Diehl 2014 Illinois State University

An In Vivo Assay For Simultaneous Monitoring Of Neuronal Activity And Behavioral Output In The Stomatogastric Nervous System Of Decapod Crustaceans, Wolfgang Stein, Florian Diehl

Faculty Publications – Biological Sciences

Central pattern generators (CPGs) generate rhythmic output patterns and drive vital behaviors such as breathing, swallowing, locomotion and chewing 1-10. While most insights into the rhythm generating mechanisms of CPGs have been derived from isolated nervous system preparations, the relationship between neural activity and corresponding behavioral expression is often unclear. The stomatogastric system of decapod crustaceans is one of the best characterized neural system for motor pattern generation 9-12 and many mechanisms of motor pattern generation and selection have been discovered in this system. Since most studies are limited to the isolated nervous system, little is known about the actual ...


The Hippocampus Participates In A Pharmacological Rat Model Of Absence Seizures, Justin Andrew Arcaro 2013 Western University

The Hippocampus Participates In A Pharmacological Rat Model Of Absence Seizures, Justin Andrew Arcaro

University of Western Ontario - Electronic Thesis and Dissertation Repository

The thalamocortical network is responsible for the generation of spike-and-wave discharges (SWDs) in absence epilepsy. Recent studies suggest a potential involvement of the hippocampus, which may explain the variability in the extent of cognitive deficits among patients with absence epilepsy. I hypothesize that the hippocampus may become entrained in spike-and-wave discharges following thalamocortical activation. The gamma-butyrolactone (GBL) rat model of absence seizures was used in this thesis. Following GBL injection, SWDs of 4 to 6 Hz developed in the spontaneous local field potentials (LFPs) recorded by depth electrodes in the thalamus, neocortex and hippocampus. Synchronization of hippocampal, thalamic and neocortical ...


Reaching For The Light: The Prioritization Of Conspicuous Visual Stimuli For Reflexive Target-Directed Reaching, Daniel K. Wood 2013 Western University

Reaching For The Light: The Prioritization Of Conspicuous Visual Stimuli For Reflexive Target-Directed Reaching, Daniel K. Wood

University of Western Ontario - Electronic Thesis and Dissertation Repository

The degree to which something stands out against the background of its environment communicates important information. The phenomenon of camouflage is a testament of the degree to which visual salience and probability of survival tend to overlap. Salient stimuli often elicit fast, reflexive movements in order to catch prey or avoid a predator. The overarching goal of the work presented in this thesis is to investigate how the physical salience of visual stimuli influence the programming and execution of reaching movements. I approached this question by recording kinematics and muscle responses during reaching movements. Broadly, this thesis investigates the effect ...


Neuroprotective Agents For Traumatic Brain Injury: Theoretical Therapy Or The Future Of Treatment?, Helen Genis 2013 McMaster University

Neuroprotective Agents For Traumatic Brain Injury: Theoretical Therapy Or The Future Of Treatment?, Helen Genis

The Meducator

An increasing awareness of concussions in sports has led researchers to uncover that brain tissue damage is not instantaneous, but rather a delayed process following the initial injury. Recently, neuroprotective agents have been developed that will be administered after injury to reduce the effects of Traumatic Brain Injury (TBI). These agents include NMDA receptor antagonists that aim to interfere with excitotoxicity and reduce neuronal death. While these agents have improved learning and cognitive performance in animal models, their effects have not been as positive in clinical trials. Calpain inhibitors have also shown neuroprotective effects, and protect against axonal damage in ...


Developmental And Molecular Functions Of Plakophilin-3, William A. Munoz 2013 Texas Medical Center Library

Developmental And Molecular Functions Of Plakophilin-3, William A. Munoz

UT GSBS Dissertations and Theses (Open Access)

Plakophilin-3, the less studied member of the plakophilin-catenin subfamily, and the larger catenin family, binds directly to desmosomal cadherin cytoplasmic domains and enhances desmosome formation and stability. In mammals, plakophilin-3 is expressed at the highest levels in desmosome-enriched tissues such as epithelia, with the knock-out in mice producing corresponding reductions in ectodermal integrity. In tissue, cellular and intracellular contexts where plakophilin-3 is not at the desmosomal plaque, little is known about its functions in the cytoplasm or nucleus, where it also localizes.

My work employed embryos of the amphibian, Xenopus laevis, to examine plakophilin-3’s developmental roles. I first evaluated ...


Acceleration Of Image Analyst Training With Transcranial Direct Current Stimulation, R. Andy McKinley, Lindsey McIntire, Nathaniel Bridges, Charles Goodyear, Michael Patrick Weisend 2013 Wright State University

Acceleration Of Image Analyst Training With Transcranial Direct Current Stimulation, R. Andy Mckinley, Lindsey Mcintire, Nathaniel Bridges, Charles Goodyear, Michael Patrick Weisend

Wright State Research Institute Publications

Humans today are routinely and increasingly presented with vast quantities of data that challenge their capacity for efficient processing. To restore the balance between man and machine, it is worthwhile to explore new methods for enhancing or accelerating this capacity. This study was designed to investigate the efficacy of transcranial DC stimulation (tDCS) to reduce training time and increase proficiency in spatial recognition using a simulated synthetic aperture radar (SAR) task. Twenty-seven Air Force active duty members volunteered to participate in the study. Each participant was assigned to 1 of 3 stimulation groups and received two, 90-min training sessions on ...


Moral Dilemma Judgment Revisited: A Loreta Analysis, Armando F. Rocha, FábioT T. Rocha, Eduardo Massad 2013 SelectedWorks

Moral Dilemma Judgment Revisited: A Loreta Analysis, Armando F. Rocha, Fábiot T. Rocha, Eduardo Massad

Armando F Rocha

Recent neuroscience investigations on moral judgment have provided useful information about how brain processes such complex decision making. All these studies so were fMRI investigations and therefore constrained by the poor resolution of this technique. Recent advances in electroencephalography (EEG) analysis provided by Low Resolution Tomogray (Loreta), Principal Component (PCA), Correlation and Regression Analysis improved EEG spatial resolution and make EEG a very useful technique in decision-making studies. Here, we reinvestigate previously fMRI study of personal (PD) and impersonal (ID) moral dilemma judgment, taking profit of these new EEG analysis improvements. Compared to the previous fMRI results, Loreta and PCA ...


Cultural Perceptions Of Traumatic Brain Injury And Rehabilitation In Minorities, Lyanna Díaz 2013 University of Puget Sound

Cultural Perceptions Of Traumatic Brain Injury And Rehabilitation In Minorities, Lyanna Díaz

Sound Neuroscience: An Undergraduate Neuroscience Journal

A person's culture can greatly affect the way they perceive illnesses, doctor-patient interactions, and rehabilitation. Factors include family, religion, and values. A lack of cultural competency training in the health professions may be detrimental to the recovery process of minorities. This phenomenon is examined in depth as it relates to Traumatic Brain Injury (TBI).


The Treatment Of Mental Disorders Through Medication, Jessica Jaynes 2013 University of Puget Sound

The Treatment Of Mental Disorders Through Medication, Jessica Jaynes

Sound Neuroscience: An Undergraduate Neuroscience Journal

Diagnosis plays a huge role in the successful treatment of mental disorders. Subtle differences in symptoms can lead to different diagnoses, and therefore different prescribed medications. The neurological causes of anxiety, depression, bipolar disorder, and ADHD are examined; as well as the mechanisms of the drugs commonly used to treat them.


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