Neuroscience and Neurobiology Commons^™

An Infrasonic Missing Fundamental Rises At 18.5hz, Christopher D. Lacomba, Steven A. Lloyd, Ryan A. Shanks

Papers and Publications: Interdisciplinary Journal of Undergraduate Research

The Missing Fundamental (MF) phenomenon is an auditory processing artifact which arises from the perception of a harmonically-structured complex sound in the absence of the complex sound’s fundamental frequency (f₀). Constructive interference occurring between constituent waveforms of the harmonic series may elicit a perceptible tone at the f₀’s pitch. A related illusion, known as binaural auditory beats (BAB), may also generate nonexistent perceptible pitches through a shared mechanism. A harmonic series suggesting to an infrasonic f₀ (1/f) noise and broken MF conditions. This data suggests that an infrasonic MF tone is generated, despite the ...

Effects On Pharmacological Properties Of Chimeric Α6Β2Β3* Achrs With Α3 Cytoplasmic Domain(S) And The Ml (Methionine To Leucine) Mutation At Position 211 Of Α6, Carson K. Ley

Carson K Ley

α6β2β3* acetylcholine receptors (AChRs) on dopaminergic neurons located in the brain are critical targets for drugs to treat nicotine addiction and Parkinson's disease. a6 and a3 are acetylcholine receptor (AChR) subunits closely related in sequence. a3 assembles efficiently with b2 subunits to form functional AChRs in Xenopus laevis oocytes, but a6 does not, presumably because specific chaperones needed for efficient expression are missing (Gotti et al., 2010). Chimeras of a6 with a3 assemble efficiently to form functional AChRs . To be useful and not misleading, it is vital that the chimeras incorporate only enough a3 sequence to insure efficient assembly ...

The Development Of Electroconvulsive Therapy, Deborah J. Sevigny-Resetco

Sound Neuroscience: An Undergraduate Neuroscience Journal

The current acceptance of electroconvulsive therapy (ECT) as a suitable treatment for depression is a result of years of medical and ethical controversy. The treatment faced social, political, and scientific barriers as it developed; however, its effectiveness in treating mental disorders has allowed it to remain in use to this day. This paper will trace the changes electroconvulsive therapy has seen in technology, application, and societal endorsement over the years.

Multi-Modal Approach For Investigating Brain And Behavior Changes In An Animal Model Of Traumatic Brain Injury, Meghan E. Heffernan, Wei Huang, Kenneth M. Sicard, Bernt T. Bratane, Nanyin Zhang, Marc Fisher, Jean A. King, Elif M. Sikoglu

Psychiatry Publications and Presentations

Utilization of novel approaches in imaging modalities are needed for enhancing diagnostic and therapeutic outcomes of persons suffering a traumatic brain injury (TBI). This study explored the feasibility of using functional magnetic resonance imaging (fMRI) in conjunction with behavioral measures to target dynamic changes in specific neural circuitries in an animal model of traumatic brain injury. Wistar rats were randomly assigned to one of two groups (traumatic brain injury / sham operation). TBI rats were subjected to the closed head injury (CHI) model. Any observable motor deficits and cognitive deficits associated with the injury were measured using Beam Walk and Morris ...

Long-Term Influence Of Normal Variation In Neonatal Characteristics On Human Brain Development, Kristine Beate Walhovd, Anders M. Fjell, Timothy T. Brown, Joshua M. Kuperman, Yoonho Chung, Donald J. Hagler Jr., J. Cooper Roddey, Matthew Erhart, Connor Mccabe, Natacha Akshoomoff, David G. Amaral, Cinnamon S. Bloss, Ondrej Libiger, Nicholas J. Schork, Burcu F. Darst, B. J. Casey, Linda Chang, Thomas M. Ernst, Jean A. Frazier, Jeffrey R. Gruen, Walter E. Kaufmann, Sarah S. Murray, Peter Van Zijl, Stewart Mostofsky, Anders Dale, Pediatric Imaging, Neurocognition, And Genetics Study

Psychiatry Publications and Presentations

It is now recognized that a number of cognitive, behavioral, and mental health outcomes across the lifespan can be traced to fetal development. Although the direct mediation is unknown, the substantial variance in fetal growth, most commonly indexed by birth weight, may affect lifespan brain development. We investigated effects of normal variance in birth weight on MRI-derived measures of brain development in 628 healthy children, adolescents, and young adults in the large-scale multicenter Pediatric Imaging, Neurocognition, and Genetics study. This heterogeneous sample was recruited through geographically dispersed sites in the United States. The influence of birth weight on cortical thickness ...

Bioenergetic Measurements In Children With Bipolar Disorder: A Pilot 31p Magnetic Resonance Spectroscopy Study, Elif M. Sikoglu, J. Eric Jensen, Gordana Vitaliano, Ana A. Liso Navarro, Perry F. Renshaw, Jean A. Frazier, Constance M. Moore

Psychiatry Publications and Presentations

BACKGROUND: Research exploring Bipolar Disorder (BD) phenotypes and mitochondrial dysfunction, particularly in younger subjects, has been insufficient to date. Previous studies have found abnormal cerebral pH levels in adults with BD, which may be directly linked to abnormal mitochondrial activity. To date no such studies have been reported in children with BD.

METHODS: Phosphorus Magnetic Resonance Spectroscopy ((31)P MRS) was used to determine pH, phopshocreatine (PCr) and inorganic phosphate (Pi) levels in 8 subjects with BD and 8 healthy comparison subjects (HCS) ages 11 to 20 years old.

RESULTS: There was no significant difference in pH between the patients ...

Molly: The Not So Convincing Truth Of Mdma, Alison Cromer

Sound Neuroscience: An Undergraduate Neuroscience Journal

This article discusses the schedule classification and effects of MDMA. The potential damage, therapeutic effects and reclassification of MDMA are examined in a new perspective that challenges past notions which lead to it's scheduling as a class one drug.

History Of Phrenology, Selena Aston

Sound Neuroscience: An Undergraduate Neuroscience Journal

Though phrenology is no longer considered a valid method of studying the brain, it did raise interesting questions that still help drive neuroscientific research today. This paper outlines the history of phrenology, and the contributions it made to the field of neuroscience.

Schizophrenia: Then And Now, Christina Lee

Sound Neuroscience: An Undergraduate Neuroscience Journal

The term "schizophrenia" was introduced over 100 years ago and it is a psychological disorder characterized by a loss of contact with reality as well as a disruption of thought, perception, mood, and movement. Throughout the years, a lot of information has been uncovered but there is still a lot of progress to be made in terms of understanding its etiology and in creating effective treatment options.

The Progression Of A Disease: An Overview Of Schizophrenia, Lucas Stone

Sound Neuroscience: An Undergraduate Neuroscience Journal

Schizophrenia is a largely undiscovered disease. Researchers haven't discovered a mechanism for effects and they still do not completely know how it affects the brain. The COMT gene as well as the epigenetic regulation of certain glutaminergic and GABAergic neurotransmitters have been proposed as possible causes for Schizophrenia, but like most research of this disease, it is not proven. The treatment for this disease has gotten better, but there still is not one that does not involve altering the natural processes of the brain.

Schizophrenia: Then And Now, Christina Lee

Sound Neuroscience Temporary

The term "schizophrenia" was introduced over 100 years ago and it is a psychological disorder characterized by a loss of contact with reality as well as a disruption of thought, perception, mood, and movement. Throughout the years, a lot of information has been uncovered but there is still a lot of progress to be made in terms of understanding its etiology and in creating effective treatment options.

History Of Phrenology, Selena Aston

Sound Neuroscience Temporary

Though phrenology is no longer considered a valid method of studying the brain, it did raise interesting questions that still help drive neuroscientific research today. This paper outlines the history of phrenology, and the contributions it made to the field of neuroscience.

Molly: The Not So Convincing Truth Of Mdma, Alison Cromer

Sound Neuroscience Temporary

This article discusses the schedule classification and effects of MDMA. The potential damage, therapeutic effects and reclassification of MDMA are examined in a new perspective that challenges past notions which lead to it's scheduling as a class one drug.

Feminist Phenomenology, Embedded Embodied Cognition, And [Pseudo] Scientific Gender Claims, Veronica Vasterling

Future Directions in Feminist Phenomenology

No abstract provided.

From Armchair To Wheelchair: How Patients With A Locked-In Syndrome Integrate Bodily Changes In Experienced Identity, Marie-Christine Nizzi

Future Directions in Feminist Phenomenology

No abstract provided.

The Effects Of Pedagogical Conditions On Second Language Acquisition, Mccall Evonne Sarrett

University of Tennessee Honors Thesis Projects

No abstract provided.

Widespread Aggregation Of Mutant Vapb Associated With Als Does Not Cause Motor Neuron Degeneration Or Modulate Mutant Sod1 Aggregation And Toxicity In Mice, Linghua Qiu, Tao Qiao, Melissa Beers, Weijia Tan, Hongyan Wang, Bin Yang, Zuoshang Xu

Open Access Articles

BACKGROUND: A proline-to-serine substitution at position-56 (P56S) of vesicle-associated membrane protein-associated protein B (VAPB) causes a form of dominantly inherited motor neuron disease (MND), including typical and atypical amyotrophic lateral sclerosis (ALS) and a mild late-onset spinal muscular atrophy (SMA). VAPB is an integral endoplasmic reticulum (ER) protein and has been implicated in various cellular processes, including ER stress, the unfolded protein response (UPR) and Ca2+ homeostasis. However, it is unclear how the P56S mutation leads to neurodegeneration and muscle atrophy in patients. The formation of abnormal VAPB-positive inclusions by mutant VAPB suggests a possible toxic gain of function as ...

The History Of Schizophrenia: Denotation Or Connotation?, Luisa M. Kennefick

Sound Neuroscience: An Undergraduate Neuroscience Journal

A solid definition of schizophrenia has been elusive since the first attempt to define it in the 19^th century. This review covers the history of schizophrenia from “dementia praecox” to the current understanding and briefly discusses how the advent of modern genetics can provide a useful tool for the redefinition of schizophrenia, particularly with regards to future research in developing treatments and therapies.

Characterization Of The Apoptotic Functions Of The Hid Hmolog Isolated From Megaselia Scalaris, Shannon Smith

University of Tennessee Honors Thesis Projects

No abstract provided.

Localization Of Seismic Signals By The Fiddler Crab, Uca Pugilator, Thomas M. Beazley

University of Tennessee Honors Thesis Projects

No abstract provided.