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Evaluation Of Motor Cortex Neuronal Morphology In Developmental Hyperserotonemia Rat Model, Colten Z. Dillinger 2018 Missouri State University

Evaluation Of Motor Cortex Neuronal Morphology In Developmental Hyperserotonemia Rat Model, Colten Z. Dillinger

MSU Graduate Theses

Fetal serotonin levels are involved in the development of the serotonergic system in an autoregulatory manner as well as the organization and connectivity of non-serotonergic neurons. Insufficient serotonin levels during development result in improper neuronal maturation and decreased synaptogenesis. Conversely, excess developmental serotonin levels can alter the progression of serotonergic neurons, ultimately resulting in a chronic decrease of serotonin in the developed brain via a negative feedback mechanism. There is a known correlation between autistic patients and chronically decreased brain serotonin concentrations; this is potentially implicated in the impaired development of the autistic brain. Incomplete or delayed development of motor ...


Combinatorial Geometry Of Threshold-Linear Networks, Christopher Langdon 2018 Illinois State University

Combinatorial Geometry Of Threshold-Linear Networks, Christopher Langdon

Annual Symposium on Biomathematics and Ecology: Education and Research

No abstract provided.


Decision Making In A Changing Environment, Alan Veliz-Cuba 2018 University of Dayton

Decision Making In A Changing Environment, Alan Veliz-Cuba

Annual Symposium on Biomathematics and Ecology: Education and Research

No abstract provided.


Hopfield Networks: Modeling Memory, Maria Gabriela Navas Zuloaga 2018 Illinois State University

Hopfield Networks: Modeling Memory, Maria Gabriela Navas Zuloaga

Annual Symposium on Biomathematics and Ecology: Education and Research

No abstract provided.


_Chemosensory Role Of A Reproductive Hormone- Associating Gnrh Neurons With Taste And Olfactory Systems In Teleost Fish Format 2.Pptx, Gabriel McHugh 2018 University of Puget Sound

_Chemosensory Role Of A Reproductive Hormone- Associating Gnrh Neurons With Taste And Olfactory Systems In Teleost Fish Format 2.Pptx, Gabriel Mchugh

Gabriel McHugh

Poster for presentation


Lipopolysaccharide‐Induced Inflammation Does Not Alter Muscle Spindle Afferent Mechanosensation Or Sensory Integration In The Spinal Cord Of Adult Mice, Dasha Zaytseva, Anusha Allawala, Joy Franco, Shea Putnam, Adam Abtahie, Nina Bubalo, Connor Criddle, Tuan Nguyen, Peter Nguyen, Shreejit Padmanabhan, Puneet Sanghera, Martina Bremer, Tzvia Abramson, Katherine A. Wilkinson 2018 San Jose State University

Lipopolysaccharide‐Induced Inflammation Does Not Alter Muscle Spindle Afferent Mechanosensation Or Sensory Integration In The Spinal Cord Of Adult Mice, Dasha Zaytseva, Anusha Allawala, Joy Franco, Shea Putnam, Adam Abtahie, Nina Bubalo, Connor Criddle, Tuan Nguyen, Peter Nguyen, Shreejit Padmanabhan, Puneet Sanghera, Martina Bremer, Tzvia Abramson, Katherine A. Wilkinson

Faculty Publications

Inflammation is known to alter nervous system function, but its effect on muscle spindle afferent mechanosensation and sensory integration in the spinal cord has not been well studied. We tested the hypothesis that systemic inflammation induced by an intraperitoneal injection of the endotoxin lipopolysaccharide (LPS; 7.5 × 105 endotoxin units/kg 18 h before experiment) would alter muscle spindle afferent mechanosensation and spinal cord excitability to Group Ia input in male and female adult C57Bl/6 mice. LPS injection caused a systemic immune response, evidenced by decreased white blood cell, monocyte, and lymphocyte concentrations in the blood, increased blood granulocyte ...


Lipopolysaccharide‐Induced Inflammation Does Not Alter Muscle Spindle Afferent Mechanosensation Or Sensory Integration In The Spinal Cord Of Adult Mice, Dasha Zaytseva, Anusha Allawala, Joy A. Franco, Shea Putnam, Adam M. Abtahie, Nina Bubalo, Connor R. Criddle, Tuan A. Nguyen, Peter Nguyen, Shreejit Padmanabhan, Puneet Sanghera, Martina Bremer, Tzvia Abramson, Katherine A. Wilkinson 2018 San Jose State University

Lipopolysaccharide‐Induced Inflammation Does Not Alter Muscle Spindle Afferent Mechanosensation Or Sensory Integration In The Spinal Cord Of Adult Mice, Dasha Zaytseva, Anusha Allawala, Joy A. Franco, Shea Putnam, Adam M. Abtahie, Nina Bubalo, Connor R. Criddle, Tuan A. Nguyen, Peter Nguyen, Shreejit Padmanabhan, Puneet Sanghera, Martina Bremer, Tzvia Abramson, Katherine A. Wilkinson

Katherine A. Wilkinson

Inflammation is known to alter nervous system function, but its effect on muscle spindle afferent mechanosensation and sensory integration in the spinal cord has not been well studied. We tested the hypothesis that systemic inflammation induced by an intraperitoneal injection of the endotoxin lipopolysaccharide (LPS; 7.5 × 105 endotoxin units/kg 18 h before experiment) would alter muscle spindle afferent mechanosensation and spinal cord excitability to Group Ia input in male and female adult C57Bl/6 mice. LPS injection caused a systemic immune response, evidenced by decreased white blood cell, monocyte, and lymphocyte concentrations in the blood, increased blood granulocyte ...


Lipopolysaccharide‐Induced Inflammation Does Not Alter Muscle Spindle Afferent Mechanosensation Or Sensory Integration In The Spinal Cord Of Adult Mice, Dasha Zaytseva, Anusha Allawala, Joy A. Franco, Shea Putnam, Adam M. Abtahie, Nina Bubalo, Connor R. Criddle, Tuan A. Nguyen, Peter Nguyen, Shreejit Padmanabhan, Puneet Sanghera, Martina Bremer, Tzvia Abramson, Katherine A. Wilkinson 2018 San Jose State University

Lipopolysaccharide‐Induced Inflammation Does Not Alter Muscle Spindle Afferent Mechanosensation Or Sensory Integration In The Spinal Cord Of Adult Mice, Dasha Zaytseva, Anusha Allawala, Joy A. Franco, Shea Putnam, Adam M. Abtahie, Nina Bubalo, Connor R. Criddle, Tuan A. Nguyen, Peter Nguyen, Shreejit Padmanabhan, Puneet Sanghera, Martina Bremer, Tzvia Abramson, Katherine A. Wilkinson

Tzvia Abramson

Inflammation is known to alter nervous system function, but its effect on muscle spindle afferent mechanosensation and sensory integration in the spinal cord has not been well studied. We tested the hypothesis that systemic inflammation induced by an intraperitoneal injection of the endotoxin lipopolysaccharide (LPS; 7.5 × 105 endotoxin units/kg 18 h before experiment) would alter muscle spindle afferent mechanosensation and spinal cord excitability to Group Ia input in male and female adult C57Bl/6 mice. LPS injection caused a systemic immune response, evidenced by decreased white blood cell, monocyte, and lymphocyte concentrations in the blood, increased blood granulocyte ...


Underlying Contribution Of Executive Functioning To Cognition And Academic Achievement In Individuals With Dystrophinopathy, Robert Fee 2018 The Graduate Center, City University of New York

Underlying Contribution Of Executive Functioning To Cognition And Academic Achievement In Individuals With Dystrophinopathy, Robert Fee

All Dissertations, Theses, and Capstone Projects

Dystrophinopathy is a genetic disorder that results in the lack of or abnormal expression of the protein dystrophin. It is a disorder that alters cell structure and function, impacts the developing brain and brain function, presents with multi-domain cognitive deficits, and influences both mood and behavior. Cognitive impairments appear to be more localized to specific areas of functioning rather than a global deficit; however, deficits have been identified across multiple cognitive domains including language and aspects of executive functioning. A careful examination of the cognitive phenotype and its association to mutations affecting CNS isoforms is necessary to clarify the neuropsychological ...


The Relationship Between Cognitive And Neural Bases Of Metamemory Judgments, Alexandra M. Gaynor 2018 The Graduate Center, City University of New York

The Relationship Between Cognitive And Neural Bases Of Metamemory Judgments, Alexandra M. Gaynor

All Dissertations, Theses, and Capstone Projects

Metamemory monitoring, the process of making subjective assessments of the status of one’s own memory, is crucial to guiding behavior and effective learning. Past cognitive research has shown that subjective confidence judgments are inferential in nature, and based on cues available at the time of the judgment. When confidence is based on cues that are related to objective memory performance, metamemory accuracy is high. However, past studies have shown that metamemory monitoring tends to be inaccurate because individuals base their confidence on information that is not predictive of memory success, such as the fluency with which items were encoded ...


The Inter-Subject Correlation Of Eeg In Response To Naturalistic Stimuli, Samantha S. Cohen 2018 The Graduate Center, City University of New York

The Inter-Subject Correlation Of Eeg In Response To Naturalistic Stimuli, Samantha S. Cohen

All Dissertations, Theses, and Capstone Projects

Inter-subject correlation is a measure of the similarity of the brain activity of a group of people as they respond to the same naturalistic stimulus, typically a story or video, meant to simulate a real world experience. This thesis tests the hypothesis that the correlation of the brain responses of a group of people is indicative of stimulus engagement. The rationale is that the content of the stimulus drives brain activity in a consistent manner, while internal thoughts are divergent and result in uncorrelated activity. The inter-subject correlation (ISC) of neural responses have previously been assessed with fMRI, EEG, and ...


Dietary Curcumin Promotes Resilience To Chronic Social Defeat Stress In A Highly Susceptible Mouse Strain, Antonio V. Aubry 2018 The Graduate Center, City University of New York

Dietary Curcumin Promotes Resilience To Chronic Social Defeat Stress In A Highly Susceptible Mouse Strain, Antonio V. Aubry

All Dissertations, Theses, and Capstone Projects

Chronic exposure to stress is a risk factor for the development of major depression and post traumatic stress disorder in humans and induces depressive- and anxiety-like phenotypes in rodents. However, there are few pharmacological interventions available that effectively treat maladaptive responses to chronic stress in the clinical setting. One therapeutic agent that has recently shown promise in treating psychiatric disorders is curcumin, a yellow-pigmented polyphenol compound found in the turmeric plant. Curcumin has been shown to prevent the development of stressed-induced depressive-like behavior in rodents and reduce symptoms of depression in clinically diagnosed patients. In this dissertation, I investigated whether ...


Characterizing The Cognitive And Emotional Effects Of Delta-9-Tetrahydrocannabinol In Distinct Hippocampal Sub-Regions, Dinat Khan 2018 The University of Western Ontario

Characterizing The Cognitive And Emotional Effects Of Delta-9-Tetrahydrocannabinol In Distinct Hippocampal Sub-Regions, Dinat Khan

Electronic Thesis and Dissertation Repository

The objective of this study is to determine the potential differential effects of THC in the DH or VH sub-regions, as well as the upstream effects on PFC neuronal activity and oscillations. Rodents used for electrophysiology were infused with THC or vehicle in the DH or VH regions, combined with PFC recordings. Additionally, a battery of behavioural paradigms was performed. Deficits in short-term memory when THC was infused into both regions was observed, however working memory was impaired with VH infusions only. This could be due to THC-induced dysregulation in the PFC, as beta oscillations were significantly decreased selectively in ...


Characterization Of The Celf6 Rna Binding Protein: Effects On Mouse Vocal Behavior And Biochemical Function, Michael A. Rieger 2018 Washington University in St. Louis

Characterization Of The Celf6 Rna Binding Protein: Effects On Mouse Vocal Behavior And Biochemical Function, Michael A. Rieger

Arts & Sciences Electronic Theses and Dissertations

Behavior in higher eukaryotes is a complex process which integrates signals in the environment, the genetic makeup of the organism, and connectivity in the nervous system to produce extremely diverse adaptations to the phenomenon of existence. Unraveling the subcellular components that contribute to behavioral output is important for both understanding how behavior occurs in an unperturbed state, as well as understanding how behavior changes when the underlying systems that generate it are altered. Of the numerous molecular species that make up a cell, the regulation of messenger RNAs (mRNAs), the coding template of all proteins, is of key importance to ...


Tributyltin Inhibits Neural Induction Of Human Induced Pluripotent Stem Cells, Shigeru Yamada, Yusuke Kubo, Daiju Yamazaki, Yuko Sekino, Yoko Nomura, Sachiko Yoshida, Yusunari Kanda 2018 National Institute of Health Sciences

Tributyltin Inhibits Neural Induction Of Human Induced Pluripotent Stem Cells, Shigeru Yamada, Yusuke Kubo, Daiju Yamazaki, Yuko Sekino, Yoko Nomura, Sachiko Yoshida, Yusunari Kanda

Publications and Research

Tributyltin (TBT), one of the organotin compounds, is a well-known environmental pollutant. In our recent study, we reported that TBT induces mitochondrial dysfunction, in human-induced pluripotent stem cells (iPSCs) through the degradation of mitofusin1 (Mfn1), which is a mitochondrial fusion factor. However, the effect of TBT toxicity on the developmental process of iPSCs was not clear. The present study examined the effect of TBT on the differentiation of iPSCs into the ectodermal, mesodermal, and endodermal germ layers. We found that exposure to nanomolar concentration of TBT (50 nM) selectively inhibited the induction of iPSCs into the ectoderm, which is the ...


Working Memory And Falls Risk In Older Adults: An Event-Related Potential Study, Yee (Michelle) S. Wong 2018 The University of Western Ontario

Working Memory And Falls Risk In Older Adults: An Event-Related Potential Study, Yee (Michelle) S. Wong

Electronic Thesis and Dissertation Repository

BACKGROUND: The aging population is rapidly increasing, where currently in North America, the population of older adults (ages 60+) outnumbers the population of children. Falls are a major concern for older adults and their quality of life. Cognitive impairment has been shown to be declined in older adults at-risk for falls, but working memory has not been thoroughly investigated within this population. PURPOSE: To examine differences in Non-Fallers, Moderate Risk for Falls, and Fallers in a working memory task using electroencephalography (EEG). METHODS: Older adults (n=44, female=27) aged 60 – 80 years (m=68.8, SD=4.7) completed ...


Targeting Pro-Inflammatory Function Of Microglia Using Small Molecules To Combat Neurodegeneration, Gabrielle C. Williams, Priya Prakash, Gaurav Chopra 2018 Purdue University

Targeting Pro-Inflammatory Function Of Microglia Using Small Molecules To Combat Neurodegeneration, Gabrielle C. Williams, Priya Prakash, Gaurav Chopra

The Summer Undergraduate Research Fellowship (SURF) Symposium

Microglia are the brain’s resident immune cells that are responsible for maintaining homeostasis in healthy conditions. During injury or infection, resting microglia get activated and produce pro-inflammatory cytokines such as IL-1b, IL-1a, IL-6, etc. along with reactive oxygen species like nitric oxide (NO) to combat neuroinflammatory diseases such as Alzheimer’s disease (AD). Inflammation is characterized by the activation of resident-immune cells in the brain called microglia that respond to the eat-me signals released by the toxic amyloid beta peptides as well as the dying neurons in the microenvironment. Recent studies have shown that activated microglia induce neuronal death ...


Neural Coding Of An Auditory Pitch Illusion, Maria Alejandra Barrera, Mark Sayles, Ravinderjit Singh 2018 University of Los Andes, Colombia

Neural Coding Of An Auditory Pitch Illusion, Maria Alejandra Barrera, Mark Sayles, Ravinderjit Singh

The Summer Undergraduate Research Fellowship (SURF) Symposium

Pitch is an important perceptual dimension in audition, supporting auditory object segregation, melody recognition and lexical distinction. Huggins’ pitch, for example, is a phenomenon evoked by two sources of broadband noise presented binaurally with an inter-aural phase shift over a narrow frequency band. Huggins’ pitch and other dichotic pitches have been studied extensively using perceptual experiments. Several models have been proposed to explain and predict the perception of pitch; however, no studies have tried to record in vivo neuron responses to Huggins’ pitch (HP) nor have tried to explain how the HP is coded by neurons. The existence of pitches ...


Examining The Associative Learning And Accumbal Dopaminergic Mechanisms Of Caffeine Reinforcement, Curtis Bradley 2018 East Tennessee State University

Examining The Associative Learning And Accumbal Dopaminergic Mechanisms Of Caffeine Reinforcement, Curtis Bradley

Electronic Theses and Dissertations

Caffeine is the most consumed psychoactive substance in the world, and most caffeine consumption in coffee and energy drinks is intended to produce a psychoactive effect. However, caffeine is not a primary reinforcer in preclinical paradigms – non-human species do not reliably take the drug to produce a psychoactive effect. However, caffeine is a ‘reinforcement enhancer’ in preclinical models; the effects of caffeine increase the motivation to obtain other non-drug reinforcers. The overall goal of this project was to determine if these reinforcement enhancing effects of caffeine could promote caffeine self-administration and to subsequently investigate the behavioral and neurochemical underpinnings of ...


Mice Lacking Kcns1 In Peripheral Neurons Show Increased Basal And Neuropathic Pain Sensitivity, Christoforos Tsantoulas, Franziska Denk, Massimo Signore, Mohammed A. Nassar, Kensuke Futai, Stephen B. McMahon 2018 King's College London

Mice Lacking Kcns1 In Peripheral Neurons Show Increased Basal And Neuropathic Pain Sensitivity, Christoforos Tsantoulas, Franziska Denk, Massimo Signore, Mohammed A. Nassar, Kensuke Futai, Stephen B. Mcmahon

Neurobiology Publications and Presentations

Voltage-gated potassium (Kv) channels are increasingly recognised as key regulators of nociceptive excitability. Kcns1 is one of the first potassium channels to be associated with neuronal hyperexcitability and mechanical sensitivity in the rat, as well as pain intensity and risk of developing chronic pain in humans. Here, we show that in mice, Kcns1 is predominantly expressed in the cell body and axons of myelinated sensory neurons positive for neurofilament-200, including Adelta-fiber nociceptors and low-threshold Abeta mechanoreceptors. In the spinal cord, Kcns1 was detected in laminae III to V of the dorsal horn where most sensory A fibers terminate, as well ...


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