Surgery Commons^™

High-Dose Oral Pyrophosphate Inhibits Connective Tissue Calcification In Abcc6 Null Mice But May Affect Bone Structure, Ibtesam Rajpar, Nicholas Yancy, Jacob Beiriger, Christina Shao, Syed Naqvi, Deana Mancuso, Fatemeh Niaziorimi, Ryan E Tomlinson, Koen Van De Wetering

Department of Orthopaedic Surgery Faculty Papers

Pseudoxanthoma elasticum (PXE) is a rare inherited disorder marked by abnormal calcium phosphate deposition in soft connective tissues, particularly the skin, arteries, and eyes. It is caused by inactivating mutations in the ABCC6 gene, which encodes a hepatic efflux transporter. Loss of ABCC6 function leads to reduced plasma levels of pyrophosphate (PPi), a key inhibitor of calcification, thereby promoting ectopic mineralization. Oral PPi therapy has emerged as a potential treatment, but its effectiveness is uncertain. Most ingested PPi is hydrolyzed in the gut to inorganic phosphate, which may worsen calcification. Moreover, its impact on mineralized tissues remains largely unexplored. Abcc6−/− …

Regional Anesthesia Utilizing Liposomal Bupivacaine, With Or Without Dexamethasone, Provides Excellent Pain Control And Minimizes Opioid Consumption Following Anterior Cruciate Ligament Reconstruction, William L. Johns, Armen Voskeridjian, Benjamin Miltenberg, Rahul Muchintala, Christopher C. Dodson, Steven B. Cohen, John Salvo, Matthew Sherman, Michael G. Ciccotti, Sommer Hammoud

Rothman Institute Papers

BACKGROUND: Perioperative nerve blocks are commonly used for regional analgesia with anterior cruciate ligament (ACL) reconstruction (ACLR). Liposomal bupivacaine (LB) is a long-acting anesthetic agent providing up to 72 hours of nerve blockade. It is theorized that the addition of dexamethasone to LB (LB+dex) may prolong the analgesic duration.

PURPOSE: To characterize pain control and opioid consumption with adductor canal block (ACB), interspace between the popliteal artery and capsule of the posterior knee (iPACK), and suprasartorial infiltration (SSI) regional anesthetic techniques utilizing LB after ACLR and to compare LB versus LB+dex.

STUDY DESIGN: Randomized controlled trial; Level of evidence, 1. …

Optimal Timing Of Cranioplasty Post-Decompressive Craniectomy In Traumatic Brain Injury: A Systematic Review, Meta-Analysis, And Overview Of Ongoing Trials, Ashviniy Thamilmaran, Shaan Patel, Shiva A. Nischal, Honey Panchal, Kush Kale, Pious D. Patel, Jack Jallo, James S. Harrop

Department of Neurosurgery Faculty Papers

BACKGROUND: The optimal timing of cranioplasty (CP) following decompressive craniectomy (DC) for the management of traumatic brain injury (TBI) remains debated. Prior studies comparing early CP (EC) and late CP (LC) report conflicting outcomes, compounded by inconsistent timing thresholds and limited attention to effect modifiers such as implant material.

OBJECTIVE: To perform a systematic review and meta-analysis comparing outcomes of EC (≤ 90 days) versus LC (> 90 days) after DC for TBI, with particular evaluation of ultra-EC (<  35 days) and implant material.

METHODS: MEDLINE, Embase, and CENTRAL were electronically searched from inception to April 2025, supplemented by manual screening of references and grey …

The Vascular Density/Angiogenesis Marker Cd31/Pecam1 Does Not Correlate With Overall Survival In Neuroendocrine Tumors, Nicholas J. Skill, Kenneth Avanzino, Yvette Bren-Mattison, J. Philip Boudreaux, Ramcharan Thiagarajan, Mary Maluccio

School of Medicine Faculty Publications

Abstract: Neuroendocrine neoplasms (NENs) are rare cancers. CD31/PECAM1 is an adhesion molecule that modulates endothelial cell-to-cell contact. Increased CD31 expression is a marker for tumor growth, and cancer aggressiveness. The purpose of this study was to better understand the prognostic value of CD31 expression in primary and metastatic NEN tumors in terms of correlations with overall survival and pathological metrics, tumor grade, and tumor primary/metastatic location. As NENs are highly vascular tumors, the hypothesis is that CD31 staining is an important prognostic biomarker and target. This is based on prior correlations between CD31 staining and 3-year recurrence-free survival in pancreas …

Spatially Resolved Integrative Analysis Of Transcriptomic And Metabolomic Changes In Tissue Injury Studies, Eleanor C Williams, Lovisa Franzén, Martina Olsson Lindvall, Gregory Hamm, Steven Oag, Muntasir Mamun Majumder, James Denholm, Azam Hamidinekoo, Javier Escudero Morlanes, Marco Vicari, Joakim Lundeberg, Laura Setyo, Trevor M Godfrey, Livia S Eberlin, Aleksandr Zakirov, Jorrit J Hornberg, Marianna Stamou, Patrik L Ståhl, Anna Ollerstam, Jennifer Y Tan, Irina Mohorianu

Faculty, Staff and Students Publications

Recent developments in spatially resolved -omics have enabled the joint study of gene expression, metabolite levels and tissue morphology, offering greater insights into biological pathways. Integrating these modalities from matched tissue sections to probe spatially-coordinated processes, however, remains challenging. Here we introduce MAGPIE, a framework for co-registering spatially resolved transcriptomics, metabolomics, and tissue morphology from the same or consecutive sections. We show MAGPIE's generalisability and scalability on spatial multi-omics data from multiple tissues, combining Visium with MALDI and DESI mass spectrometry imaging. MAGPIE was also applied to new multi-modal datasets generated with a specialised sampling strategy to characterise the metabolic …

The Efficacy And Safety Of Laparoscopic Cholecystectomy For Acute Cholecystitis: A Descriptive Study, Michael Lawenko, Marie Abigail Dumlao

The Lasallian Journal of Health

Objectives: Laparoscopic Cholecystectomy (LC) is gaining traction to become a safe and effective surgical option for Acute Cholecystitis (AC). In our institution, the trend toward laparoscopic management of AC has only recently gained traction. The objective of this study is to describe the early experience of our institu tion utilizing LC. Methods: This descriptive study involved a retrospec tive analysis of early institutional cases of LC. Included were cases with both pre- and post-operative diagnoses of AC, as well as cases admitted for non-AC conditions but found to have incidental AC postoperatively. Cases were further categorized into severe (SAC) and …

The Five-Step Teaching Method Vs Demo-Return Demo Of Laparoscopic Camera Manipulation On Medical Students: A Randomized Controlled Trial In A Philippine Medical School Curriculum, Michael Lawenko

The Lasallian Journal of Health

Objectives: This study aims to examine if laparoscopic camera manipulation, using the five-step teaching method, is more effective than the traditional demoreturn demo method in developing psychomotor and visuospatial skills in fourth year medical students. Methods: Randomization was done to create two groups (n = 129). One group, (n = 70), received training using the five-step method: (1) conceptualization, (2) visualization, (3) verbalization by the preceptor, (4) verbalization by the student, and (5) practice. The other group, (n = 59), followed the traditional demo-return demo method. Psychomotor and visuospatial skills of the students were assessed using a rubric. The subjective …

Predicting Sepsis In Heart Failure Patients Supported By Left Ventricular Assist Devices: The Role Of Ve-Cadherin And Adam10, Shiyi Li, Iván Murrieta-Álvarez, Ismael Garcia, Katherine V Nordick, Rishav Bhattacharya, Shreyo Ghosh, Ronald A Shaju, Adel M Hassan, Carl P Walther, Camila Hochman-Mendez, Alexis E Shafii, Kenneth K Liao, Nandan K Mondal

Faculty, Staff and Students Publications

Vascular endothelial cadherin (VE-Cadherin) is a major endothelial adhesion molecule and can be cleaved explicitly by metalloproteinase domain-containing protein 10 (ADAM10). Vascular hyperpermeability may contribute to a greater susceptibility to sepsis in left ventricular assist device (LVAD) support patients. We aim to evaluate the efficacy of VE-Cadherin and ADAM10 for predicting sepsis in LVAD patients. We prospectively recruited 50 patients with advanced heart failure receiving LVAD therapy. Baseline and weekly postoperative blood samples (weeks 1-4) were collected, and plasma VE-cadherin and ADAM10 levels were measured. Sepsis occurred in 9 of 50 patients (18.0%). Across all sampling points, plasma VE-cadherin and …

Medicaid Expansion And Breast Cancer Care And Outcomes-What Lies Ahead?, Meghan H. Maceyko, Oluwadamilola M. Fayanju

Department of Surgery Faculty Papers

No abstract provided.

Another Gastric Band Complication: Acute Appendicitis, Dustin Williamson, Naveed Ismail, John Weaver

Continental and Mountain Divisions GME Resarch Day 2026

No abstract provided.

Reducing Healthcare Spending With Pharmacist Driven Icg Allocation, Rachel W. Wong, Calvin Le, Vanessa Sifuentes, Faith Rutherford, Grace Desrochers, Zuhair Ali, Mike K. Liang

Gulf Coast Division GME Research Day 2026

No abstract provided.

Spontaneous Pneumoperitoneum Presenting As An Acute Abdomen, Madison Mcinnis, Megan Tierney, Kaysie Banton

Continental and Mountain Divisions GME Resarch Day 2026

No abstract provided.

Cecal Volvulus In The Setting Of Situs Inversus Totalis: A Rare Case Report, Alexandra Moody, Josie Bjorklund

Continental and Mountain Divisions GME Resarch Day 2026

No abstract provided.

Bilateral Pseudoangiomatous Stromal Hyperplasia In A Twelve-Year-Old Female: A Case Report, Alexandra Mcmillan, Taylor Sullivan, Joyce Moore, Robert M. Pride

Continental and Mountain Divisions GME Resarch Day 2026

No abstract provided.

A Predictive Tool Using The Society Of Thoracic Surgeons Risk Calculator For Safe Operating Room Extubation After Coronary Bypass Surgery, John G. Byrne, Farhaan Chaugle, Thomas Kessinger, Prince Thommen, Ali Asghar, Shahistha Hyder, Curtis Dickey, Nicole Blatt, Hannan Chaugle

Gulf Coast Division GME Research Day 2026

No abstract provided.

Use Of Bilateral Shouldice Repair For A Hydrocele Of The Canal Of Nuck Type I, David Anderson, Jay Lavrich, Kaitlan Weppner, Bradley Wise

Continental and Mountain Divisions GME Resarch Day 2026

No abstract provided.

A Case Report Of A Rare Skin Lesion: Malignant Or Benign?, Anila Punjwani, Shane Sweeney, Pierre Khoury, Mike Liang

Gulf Coast Division GME Research Day 2026

No abstract provided.

Accelerating Quality Improvement In Cabg Surgery: A Real-Time Rapid-Cycle Process Improvement Tool Guided By The Publicly Available Sts Risk Calculator, John G. Byrne, Farhaan Chaugle, Waleed Asger, Aaliyah Willis, Shelby Derose, Rachel Jones, Hannan Chaugle

Gulf Coast Division GME Research Day 2026

No abstract provided.

A Novel Less Invasive Single Port Pulsatile Ventricular Assist Device, Li Li, Jinsong Chen, Zhongjiang Zhuang, Stephen Topaz, Masashi Kawabori, Joseph B. Zwischenberger, Cherry Ballard-Croft, Dongfang Wang

Surgery Faculty Publications

A less invasive paracorporeal single port pulsatile ventricular assist device (sppVAD) was developed for cardiogenic shock. This compact sppVAD includes a valved single lumen cannula (VSLC), valveless single port diaphragm displacement pump (spDDP), and portable console. A 33/27 Fr VSLC was fabricated for mock loop testing, a 28/25 Fr VSLC was made for 6 hours sheep testing (n = 5, 44–52 kg), and valveless spDDP with portable console was made. The sppVAD (33/27 Fr VSLC) achieved 6.2 L/min flow in mock loop. In sheep, the 28/25 Fr VSLC was inserted without cardiopulmonary bypass from apex to ascending aorta within 1 …

Coil Embolization And Open Splenectomy For A Massive Splenic Vein Aneurysm: A Case Report, Kaitlyn Vu, Logan Brown, Blake Durrence, Tilak Patel, Robert Larsen, Stephanie Gordy

South Atlantic Division GME Research Days 2026

No abstract provided.