Neurology Commons^™

Correction To: Abolishing Tau Cleavage By Caspases At Aspartate421 Causes Memory/Synaptic Plasticity Deficits And Pre-Pathological Tau Alterations (Translational Psychiatry, (2017), 7, 8, (E1198), 10.1038/Tp.2017.165), F. Biundo, C. D’Abramo, M. D. Tambini, H. Zhang, D. Del Prete, F. Vitale, G. G. Giliberto, O. Arancio, L. D’Adamio

Journal Articles

© 2018, The Author(s). This article was originally published under Nature Research’s License to Publish, but has now been made available under a CC BY 4.0 license. The PDF and HTML versions of the article have been modified accordingly.

Anti-Tau Conformational Scfv Mc1 Antibody Efficiently Reduces Pathological Tau Species In Adult Jnpl3 Mice., F. Vitale, L. Giliberto, S. Ruiz, K. Steslow, P. Marambaud, C. D'Abramo

Journal Articles

Tau, the main component of the neurofibrillary tangles (NFTs), is an attractive target for immunotherapy in Alzheimer's disease (AD) and other tauopathies. MC1/Alz50 are currently the only antibodies targeting a disease-specific conformational modification of tau. Passive immunization experiments using intra-peritoneal injections have previously shown that MC1 is effective at reducing tau pathology in the forebrain of tau transgenic JNPL3 mice. In order to reach a long-term and sustained brain delivery, and avoid multiple injection protocols, we tested the efficacy of the single-chain variable fragment of MC1 (scFv-MC1) to reduce tau pathology in the same animal model, with focus on brain …

Identification Of Ethyl Pyruvate As A Nlrp3 Inflammasome Inhibitor That Preserves Mitochondrial Integrity, S. Li, F. Liang, K. Kwan, Y. Tang, X. Wang, H. Yang, S. S. Chavan, H. Wang, K. J. Tracey, +3 Additional Authors

Journal Articles

No abstract provided.

Primary Solitary Retro-Clival Amyloidoma., J. R. Schneider, K. Kwan, K. O. Kulason, L. J. Faltings, S. Colantonio, S. Safir, J. Y. Li, K. S. Black, B. T. Schaeffer, M. B. Eisenberg, +1 Additional Author

Journal Articles

Amyloidosis encompasses a group of disorders sharing the common feature of intercellular deposition of amyloid protein by several different pathogenetic mechanisms. Primary solitary amyloidosis, or amyloidoma, is a rare subset of amyloidosis in which amyloid deposition is focal and not secondary to a systemic process or plasma cell dyscrasia.This 84-year-old female presented with history of multiple syncopal episodes, dysphagia, and ataxia. Motor strength was 3+/5 in the right upper extremity. Rheumatoid factor, cyclic citrullinated peptide (CCP), and anti-nuclear antibody (ANA) were normal. Serum and urine immune-electrophoresis detected no abnormal bands. Computed tomography (CT) and magnetic resonance imaging (MRI) demonstrated a …

Induction And Quantification Of Excitability Changes In Human Cortical Networks, C. J. Keller, Y. Huang, J. L. Herrero, M. E. Fini, V. Du, F. A. Lado, C. J. Honey, A. D. Mehta

Journal Articles

No abstract provided.

Correction To: First Results On Survival From A Large Phase 3 Clinical Trial Of An Autologous Dendritic Cell Vaccine In Newly Diagnosed Glioblastoma, L. M. Liau, K. Ashkan, D. D. Tran, J. L. Campian, J. E. Trusheim, C. S. Cobbs, J. A. Heth, M. Salacz, M. Schulder, M. L. Bosch, +59 Additional Authors

Journal Articles

© 2018 The Author(s). Following publication of the original article [1], the authors reported an error in the spelling of one of the author names. In this Correction the incorrect and correct author names are indicated and the author name has been updated in the original publication. The authors also reported an error in the Methods section of the original article. In this Correction the incorrect and correct versions of the affected sentence are indicated. The original article has not been updated with regards to the error in the Methods section.

Spontaneous Intracranial Hypotension Complicated By Refractory Subdural Hematomas In A Patient With Coagulation Factor Xiii Deficiency, R. Gilad, S. L. Motivala, S. Khan, E. Chang, D. L. Klein, M. J. Raden

Journal Articles

© 2018 The Authors Spontaneous intracranial hypotension (SIH) is often secondary to an occult cerebrospinal fluid (CSF) leak in the neuroaxis. It is sometimes associated with chronic subdural hematomas (SDH). The authors present the case of a 61 year-old male who presented with SIH from an occult CSF leak and complicated by refractory SDH. The patient underwent treatment for SIH with multiple epidural blood patches, hydration and bed rest. In addition, he underwent evacuation of his SDH twice, once via burr hole drainage and the second via craniotomy. Once the diagnosis of coagulation factor XIII (CFXIII) deficiency was made, the …

Structural Brain Abnormalities In The Common Epilepsies Assessed In A Worldwide Enigma Study, C. D. Whelan, A. Altmann, J. A. Botia, N. Jahanshad, D. P. Hibar, J. Absil, Alhusaini, M. K. M. Alvim, R. Kuzniecky, S. M. Sisodiya, +81 Additional Authors

Journal Articles

No abstract provided.

Is Seizure Frequency Variance A Predictable Quantity?, D. M. Goldenholz, S. R. Goldenholz, R. Moss, J. French, D. Lowenstein, R. Kuzniecky, Z. Z. Haut, S. Cristofaro, K. Detyniecki, W. H. Theodore, +4 Additional Authors

Journal Articles

No abstract provided.

Dissociable Contributions Of The Prefrontal Cortex In Group-Based Cooperation, J. Wills, O. Feldmanhall, M. R. Meager, J. J. Van Bavel, K. Blackmon, O. Devinsky, Doyle, D. J. Luciano, R. I. Kuzniecky, U. Samadani, +8 Additional Authors

Journal Articles

© The Author(s) (2018). Published by Oxford University Press. The success of our political institutions, environmental stewardship and evolutionary fitness all hinge on our ability to prioritize collective-interest over self-interest. Despite considerable interest in the neuro-cognitive processes that underlie group cooperation, the evidence to date is inconsistent. Several papers support models of prosocial restraint, while more recent work supports models of prosocial intuition.We evaluate these competing models using a sample of lesion patients with damage to brain regions previously implicated in intuition and deliberation. Compared to matched control participants (brain damaged and healthy controls), we found that patients with dorsolateral …

Presurgical Language Fmri: Technical Practices In Epilepsy Surgical Planning, C. F. Benjamin, I. Dhingra, A. X. Li, H. Blumenfeld, R. Alkawadri, S. Bickel, Z. Z. Helmstaedter, S. Meletti, R. A. Bronen, D. D. Spencer, +5 Additional Authors

Journal Articles

© 2018 The Authors Human Brain Mapping Published by Wiley Periodicals, Inc. Little is known about how language functional MRI (fMRI) is executed in clinical practice in spite of its widespread use. Here we comprehensively documented its execution in surgical planning in epilepsy. A questionnaire focusing on cognitive design, image acquisition, analysis and interpretation, and practical considerations was developed. Individuals responsible for collecting, analyzing, and interpreting clinical language fMRI data at 63 epilepsy surgical programs responded. The central finding was of marked heterogeneity in all aspects of fMRI. Most programs use multiple tasks, with a fifth routinely using 2, 3, …

Safety And Efficacy Of A 3-Dimensional Stent Retriever With Aspiration-Based Thrombectomy Vs Aspiration-Based Thrombectomy Alone In Acute Ischemic Stroke Intervention A Randomized Clinical Trial, R. G. Nogueira, D. Frei, J. F. Kirmani, O. Zaidat, D. Lopes, A. S. Turk, D. Heck, B. Mason, D. Langer, A. Siddiqui, +9 Additional Authors

Journal Articles

No abstract provided.

First Results On Survival From A Large Phase 3 Clinical Trial Of An Autologous Dendritic Cell Vaccine In Newly Diagnosed Glioblastoma, L. M. Liau, K. Ashkan, D. D. Tran, J. L. Campian, J. E. Trusheim, C. S. Cobbs, J. A. Heth, M. Salacz, M. Schulder, M. L. Bosch, +59 Additional Authors

Journal Articles

© 2018 The Author(s). Background: Standard therapy for glioblastoma includes surgery, radiotherapy, and temozolomide. This Phase 3 trial evaluates the addition of an autologous tumor lysate-pulsed dendritic cell vaccine (DCVax®-L) to standard therapy for newly diagnosed glioblastoma. Methods: After surgery and chemoradiotherapy, patients were randomized (2:1) to receive temozolomide plus DCVax-L (n = 232) or temozolomide and placebo (n = 99). Following recurrence, all patients were allowed to receive DCVax-L, without unblinding. The primary endpoint was progression free survival (PFS); the secondary endpoint was overall survival (OS). Results: For the intent-to-treat (ITT) population (n = 331), median OS (mOS) was …

Aerobic Exercise Training And Inducible Inflammation: Results Of A Randomized Controlled Trial In Healthy, Young Adults., R. P. Sloan, P. A. Shapiro, P. S. Mckinley, M. Bartels, D. Shimbo, V. Lauriola, W. Karmally, M. Pavlicova, C. J. Choi, K. J. Tracey, +3 Additional Authors

Journal Articles

Background Consensus panels regularly recommend aerobic exercise for its health-promoting properties, due in part to presumed anti-inflammatory effects, but many studies show no such effect, possibly related to study differences in participants, interventions, inflammatory markers, and statistical approaches. This variability makes an unequivocal determination of the anti-inflammatory effects of aerobic training elusive. Methods and Results We conducted a randomized controlled trial of 12 weeks of aerobic exercise training or a wait list control condition followed by 4 weeks of sedentary deconditioning on lipopolysaccharide (0, 0.1, and 1.0 ng/mL)-inducible tumor necrosis factor-α (TNF-α) and interleukin-6 (IL-6), and on toll-like receptor 4 …

Targeting Dec-205(-)Dcir2(+) Dendritic Cells Promotes Immunological Tolerance In Proteolipid Protein-Induced Experimental Autoimmune Encephalomyelitis, I. Tabansky, D. B. Keskin, D. Watts, C. Petzold, M. Funaro, W. Sands, P. Wright, S. Najjar, B. Diamond, J. N. H. Stern, +4 Additional Authors

Journal Articles

No abstract provided.

Acute Effects Of Diets Rich In Almonds And Walnuts On Endothelial Function, Ravindra Bhardwaj, Harvinder Dod, Manjinder S. Sandhu, Rohil Bedi, Sachin Dod, Gregory Konat, H.K. Chopra, Rakesh Sharma, Abnash C. Jain, Navin Nanda

Faculty & Staff Scholarship

Objective: Omega-3 fatty acids, especially alpha-linolenic acid (ALA), which are present in nuts may reduce cardiovascular disease (CVD) risk, by changing vascular inflammation and improving endothelial dysfunction. The objective of the study was to evaluate the acute effects of two different diets, one containing walnuts and the other almonds on endothelial function.

Methods: Twenty-seven overweight volunteers underwent a randomized 2-period, crossover, controlled intervention study. The subjects were given either walnut or almond diets which varied in monounsaturated fatty acid (MUFA) and polyunsaturated fatty acid (PUFA) content. The walnut diet provided 23.1% energy from PUFA and the almond diet provided 7.6% …

An Exploration Into The Psychotic Symptoms Associated With Schizophrenia And Major Depressive Disorder, Kyndester I. Michael-Samaroo

Honors Undergraduate Theses

This research focuses on examining the neurological similarities between schizophrenia and major depressive disorder with psychotic features in order to compare the manifestations of psychosis in each disorder. Both disorders often involve symptoms of psychosis, although the overall disorders are very different from each other. The hypothesis for this research is that the neurological similarities between schizophrenia and major depressive disorder with psychotic features will provide researchers with the strategies needed to develop a treatment for psychotic symptoms. In order to test this hypothesis, five related studies were gathered for each disorder, and three studies were gathered for psychosis. These …

Suicidal Ideation Assessment In Individuals With Premanifest And Manifest Huntington Disease., Melissa Wesson, Nicholas R Boileau, Joel S Perlmutter, Jane S Paulsen, Stacey K Barton, Michael K Mccormack, Noelle E Carlozzi

Rowan-Virtua School of Osteopathic Medicine Departmental Research

BACKGROUND: Huntington disease (HD) is associated with increased risk of suicide.

OBJECTIVE: This study compares suicide ideation in HD to the general population, assesses factors associated with increased prevalence of suicidal thoughts, and compares clinician-rated to self-reported assessments of suicidal ideation.

METHODS: We examined 496 participants with premanifest or manifest HD. Clinician-rated suicidal ideation was measured using the Problem Behaviors Assessment - short form. Self-reported ideation was measured using two items from the HDQLIFE Concern with Death and Dying item bank. Independent sample t-tests were conducted to compare the prevalence of suicidal thoughts between our HD sample and the U.S. …

Training Neurodegenerative Disease Support Group Leaders: A New Support Group Functioning Scale, Therese V. Cash, Christopher Kilbourn, Sarah K. Lageman

Neurology Publications

Support group leaders play pivotal roles in maintaining healthy community support groups; however, these leaders also have personal support needs and typically lack formal training in managing complex behaviors of neurodegenerative disorders. A support group well-being questionnaire, assessing support group functioning, was developed and piloted among participants of an educational training program designed for support group leaders of various neurodegenerative disorder-specific support groups. An exploratory factor analysis evaluated the questionnaire’s psychometric properties and identified a reliable single factor five-item solution, which was titled the Support Group Functioning Scale (SGFS). Preliminary interpretation guidelines were proposed. Development of this scale is a …

A Gut Feeling: A Hypothesis Of The Role Of The Microbiome In Attention-Deficit/Hyperactivity Disorders., Xue Ming, Neil Chen, Carly Ray, Gretchen Brewer, Jeffrey Kornitzer, Robert A Steer

Rowan-Virtua School of Osteopathic Medicine Departmental Research

Attention-deficit/hyperactivity disorder (ADHD) is a neurologic disorder characterized by hyperactivity/impulsivity and/or inattentiveness, with genetic and environmental factors contributing to the disorder. With the growing recognition of the microbiome's role in many neurological disorders, the authors propose that it may also be implicated in ADHD. Here, we describe several evolving areas of research to support this hypothesis. First, a unique composition of gut bacteria has been identified and linked to behaviors in ADHD. Second, our research found an increased incidence of 2 gastrointestinal symptoms (constipation and flatulence) in children with ADHD, as compared to controls. Finally, emerging data may be interpreted …