Biomechanical Engineering Commons^™

Cavitation In Pharmaceutical Manufacturing And Shipping, Donn Sederstrom

Electronic Theses and Dissertations

Therapeutic proteins are used to successfully treat hemophilia, Crohn's Disease, diabetes, and cancer. Recent product recalls have occurred because of sub-visible particle formation resulting from the inherent instability of proteins. It has been suggested that particle formation is associated with late stage processing steps of filling, shipping, and delivery. Previous work at the University of Denver demonstrated that fluid cavitation can generate a large number of sub-visible protein particles in ultra clean formulations, but that mitigation can be achieved with fluid property manipulation. The goal of this research was to (1) assess the risk of cavitation under common pharmaceutical manufacturing …

Biogeography-Based Optimization For Hydraulic Prosthetic Knee Control, Tim Wilmot, George Thomas, Berney Montavon, Rick Rarick, Antonie J. Van Den Bogert, Steve Szatmary, Daniel J. Simon, William Smith, Sergey Samorezov

Electrical and Computer Engineering Faculty Publications

We discuss open-loop control development and simulation results for a newly-developed cyber-physical system (CPS) used as a semi-active, above-knee prosthesis. The control signal of our CPS consists of two hydraulic valve settings that control a linear cylinder actuator and provide torque to the prosthetic knee. We develop open-loop control using biogeography-based optimization (BBO), which is a recently developed evolutionary algorithm. The research contributes to the field of cyber-physical systems by showing that it is possible to find effective open-loop control signals for our newly proposed semi-active hydraulic knee prosthesis through a dual-system optimization process which includes both human and robot …

Stress And Strain Adaptation In Load-Dependent Remodeling Of The Embryonic Left Ventricle, Christine Buffinton

Faculty Journal Articles

Altered pressure in the developing left ventricle (LV) results in altered morphology and tissue material properties. Mechanical stress and strain may play a role in the regulating process. This study showed that confocal microscopy, three-dimensional reconstruction, and finite element analysis can provide a detailed model of stress and strain in the trabeculated embryonic heart. The method was used to test the hypothesis that end-diastolic strains are normalized after altered loading of the LV during the stages of trabecular compaction and chamber formation. Stage-29 chick LVs subjected to pressure overload and underload at stage 21 were reconstructed with full trabecular morphology …

Design, Analysis And Testing Of Haptic Feedback System For Laparoscopic Graspers In In Vivo Surgical Robots, Nikhil Salvi

Department of Mechanical and Materials Engineering: Dissertations, Theses, and Student Research

Laparo-Endoscopic Single Site (LESS) Robotics Surgery is an advanced technology in the field of Minimally Invasive Surgery (MIS). The LESS surgical robots significantly improve the surgeon’s accuracy, dexterity and visualization, and reduce the invasiveness of surgical procedure results in faster recovery time and improved cosmetic results. In a standard robotic endosurgery, the palpation of tissues is performed by laparoscopic graspers located at the end effectors. The master-slave configuration in robotic surgery leads in remote access to the operation site. Therefore, surgeon’s ability to perceive valuable sensory information is severely diminished. Sensory information such as haptics, which is essential for safe …

Research And Development Of An Extremely Affordable Prosthetic Knee, Victor H. Duenas, Noe Vargas-Hernandez

COURI Symposium Abstracts, Summer 2012

The objective of this research and development work is to apply the design process in a prosthetic knee mechanism. The importance of human knee is founded in the provided mobility, body positioning and support of the body weight. But for amputees, limitations for everyday tasks imply a real challenge. The project scope a cycle involving the social need, the development and the supply of the solution layout. The motivation is to improve life quality through voluntary and independent human movement by providing a low cost knee design.

The design process requires the conceptual, embodiment, detail and evaluation phases to complete …

Dynamic Model Of Sailors Descending A Navy Ship Ladder, Jonathan Coulter

Mechanical & Aerospace Engineering Theses & Dissertations

Knee moments are greater in individuals who climb Navy ship ladders than in people climbing stairs. Because it is known that people who climb stairs frequently are at greater risk for osteoarthritis and that people in the Navy report higher incidences of knee pain, it was hypothesized that the internal joint reaction forces during the sailor's descent of a ship ladder would be greater than internal joint reaction forces of gait and stair climbing. Dimensions of a commonly used Navy ship ladder were collected and a replica was constructed. The replica was instrumented to collect 3D kinematics and kinetics during …

Analysis Of Bar Deformation Under Sternum Forces During Surgical Correction Of Pectus Excavatum In Children, Rohit N. Nikam

Mechanical & Aerospace Engineering Theses & Dissertations

Pectus excavatum (PE) also known as sunken or funnel chest is the most common chest wall deformity and affects 1 in every 1,000 children. In PE patients, the middle lower portion of the sternum is depressed producing concave appearance of the anterior part of the chest wall. This problem can be corrected with minimally invasive surgery developed by Dr. Donald Nuss in 1986. A specially made steel bar is implanted to lift the sternum to its normal position. This technique has been modified several times to improve safety and effectiveness of the bar placement and removal. One of the significant …

Design And Testing Of A Low Cost Prosthetic Foot, Shalan Ertis, John Kearns, Seija Maniskas

Mechanical Engineering

No abstract provided.

Viscoelastic Anisotropic Finite Element Mixture Model Of Articular Cartilage Using Viscoelastic Collagen Fibers And Validation With Stress Relaxation Data, Matthew Alexander Griebel

Master's Theses

Experimental results show that collagen fibers exhibit stress relaxation under tension and a highly anisotropic distribution. To further develop the earlier model of Stender [1], the collagen constituent was updated to reflect its intrinsic viscoelasticity and anisotropic distribution, and integrated with an existing mixture model with glycosaminoglycans and ground substance matrix. A two-term Prony series expansion of the quasi-linear viscoelastic model was chosen to model the viscoelastic properties of the collagen fibers. Material parameters were determined by using the simplex method to minimize the sum of squared errors between model results and experimental stress relaxation data of tissue in tension. …

Predictive Musculoskeletal Simulation Using Optimal Control: Effects Of Added Limb Mass On Energy Cost And Kinematics Of Walking And Running, Antonie J. Van Den Bogert, Maarten Hupperets, Heiko Schlarb, Berthold Krabbe

Mechanical Engineering Faculty Publications

When designing sports equipment, it is often desirable to predict how certain design parameters will affect human performance. In many instances, this requires a consideration of human musculoskeletal mechanics and adaptive neuromuscular control. Current computational methods do not represent these mechanisms, and design optimization typically requires several iterations of prototyping and human testing. This paper introduces a computational method based on musculoskeletal modeling and optimal control, which has the capability to predict the effect of mechanical equipment properties on human performance. The underlying assumption is that users will adapt their neuromuscular control according to an optimality principle, which balances task …

Polygrasp: Reach; Myoelectric Prosthetic Hand Iteration, Devon Patrick Augustus, Mighells Blaed Deuel, Ian Noel Fraser, Nicholas Philip Moesser

Mechanical Engineering

Amputations are a common occurrence in soldiers returning home who have suffered the effects of IED and munitions explosions. For upper limb amputees, trans-radial amputations are the most common. Traditional hook devices do not offer an adequate level of normalcy for users, prompting the use of myoelectric devices. While current myoelectric devices do offer a more natural experience, they come with a host of other problems that makes their adoption by service personnel not desirable or not permitted by the VA. PolyGrasp Reach seeks to reduce weight and cost and improve performance. This addresses several of the issues with devices …

Hydraulically Driven Mechanical Representation Of A Biological System, Andrea Argouarch, Michael Mceachern, Brandon Parham

Biomedical Engineering

No abstract provided.

Prediction Of Articular Cartilage Remodeling During Dynamic Compression With A Finite Element Model, Kevin Akira Yamauchi

Master's Theses

First, an in vitro growth experiment was performed to test the hypothesis that applying dynamic unconfined compression during culture produces het- erogeneous remodeling in newborn bovine articular cartilage explants. Het- erogeneous measures of cartilage microstructure were obtained by biochemical assays and quantified polarized light microscopy. Significant differences were measured between the GAG content in the inner and outer portions of the sam- ples stimulated with dynamic unconfined compression. The COL fiber network was found to be more highly aligned in the inner portion of the sample than in the peripheral region.

Next, a poroelastic finite element model with a remodeling …

Predictive Simulation Of Gait At Low Gravity Reveals Skipping As The Preferred Locomotion Strategy, Marko Ackermann, Antonie J. Van Den Bogert

Mechanical Engineering Faculty Publications

The investigation of gait strategies at low gravity environments gained momentum recently as manned missions to the Moon and to Mars are reconsidered. Although reports by astronauts of the Apollo missions indicate alternative gait strategies might be favored on the Moon, computational simulations and experimental investigations have been almost exclusively limited to the study of either walking or running, the locomotion modes preferred under Earth's gravity. In order to investigate the gait strategies likely to be favored at low gravity a series of predictive, computational simulations of gait are performed using a physiological model of the musculoskeletal system, without assuming …

Effects Of Approach Techniques In Place Kicking: A 3d Analysis, Chase M. Pfeifer

Department of Mechanical and Materials Engineering: Dissertations, Theses, and Student Research

Various studies aim to understand the fundamentals of kicking, primarily the instep kick commonly used by soccer players. Of those studies, most are limited to a 2D analysis using high-speed cameras for position tracking and electromyography to observe muscle activity. The few studies that investigate a 3D model are limited in their position tracking capabilities and focus mainly on joint flexion potentials and foot speed. To the authors knowledge no study of this caliber has been performed on the kinematics and dynamics of place kicking in American football. This thesis uses a 12 camera high-speed motion tracking system to investigate …

Facility Implementation, Production, And Use Of Biodiesel On A University Campus, Michelle Erin Rodio

Doctoral Dissertations and Master's Theses

During the last two years, Embry-Riddle Aeronautical University has been in the process of having a fully-functional biodiesel processing facility on campus. Within this time, it was shown that biodiesel was a great alternative to diesel fuel based on emissions, performance, and cost, allowing for a grant of $10,000 being awarded to fund the project. Upon properly producing biodiesel, the fuel was tested in a John Deere 2653A tractor to see what differences, if any, existed when using a biodiesel blend over diesel fuel. In doing this, carbon buildup and fuel economy were compared, and a cost analysis conducted. It …

A Three-Dimensional Inverse Finite Element Analysis Of The Heel Pad, Snehal Chokhandre, Jason P. Halloran, Antonie J. Van Den Bogert, Ahmet Erdemir

Mechanical Engineering Faculty Publications

Quantification of plantar tissue behavior of the heel pad is essential in developing computational models for predictive analysis of preventive treatment options such as footwear for patients with diabetes. Simulation based studies in the past have generally adopted heel pad properties from the literature, in return using heel-specific geometry with material properties of a different heel. In exceptional cases, patient-specific material characterization was performed with simplified two-dimensional models, without further evaluation of a heel-specific response under different loading conditions. The aim of this study was to conduct an inverse finite element analysis of the heel in order to calculate heel-specific …

Investigation Of Carbon Corrosion Resistance Of Cnt Containing Electrode, Diana Larrabee, William A. Rigdon, Eli Mcpherson, Joshua Sightler, Xinyu Huang

Faculty Publications

Carbon support corrosion is one of the major degradation mechanisms of polymer electrolyte membrane (PEM) fuel cell. Carbon oxidation occurs in PEM electrode and is accelerated at high potential created by adverse operating conditions and improper distribution of reactants and products [1, 2, 3]. Carbon corrosion can lead to the thinning of the electrode layer and severe performance degradation. The detailed mechanisms of carbon support corrosion induced performance loss are still not fully understood; it is believed that the following events contribute to the decay: (1) structural collapse of the porous electrode due to the loss of carbon; (2) carbon …

Development Of A Robotic Platform For Upper Limb Rehabilitation, Stephen Curran, Nigel Kent, David Kennedy, James Conlon

Conference Papers

The aim of this project is to develop a rehabilitation robot intended for use in a non-specialised or domestic setting. Robots have been shown to have a positive effect on limb rehabilitation and developing rehabilitation robots for use outside of specialist rehabilitation centres could be beneficial in terms of access to, intensity and cost of treatment. The device is intended for the rehabilitation of the shoulder/elbow region of the upper limbs. The design requirements for such a device mean that it must be low cost, portable, robust and have a detailed focus on safety. Other areas of interest pertaining to …

Silk Cryogels For Microfluidics, Christopher David Hinojosa

Dissertations and Theses

Silk fibroin from silkworm cocoons is found in numerous applications ranging from textiles to medical implants. Its recent adoption as a biomaterial is due to the material's strength, biocompatibility, self-assembling behavior, programmable degradability, optical clarity, and its ability to be functionalized with antibodies and proteins. In the field of bioengineering it has been utilized as a tissue scaffolding, drug delivery system, biosensor, and implantable electrode. This work suggests a new application for porous silk in a microscale chromatography column. We demonstrate in situ cryotropic polymerization of highly porous structures in microscale geometries by freezing aqueous silk with a solvent. The …

Simvastatin Improves Spinal Fusion In Rats, Bora Bostan, Taner Güneş, Murat Aşçi, Cengiz Şen, Mehmet Halidun Keleştemur, Mehmet Erdem, Reşit Doǧan Köseoǧlu, Ünal Erkorkmaz

Faculty Publications - Mechanical Engineering

Objective: Statins stimulate bone formation by inducing the expression of bone morphogenetic proteins (BMP-2). The aim of our study was to investigate the effects of orally administered simvastatin on spinal fusion in rats. Methods: Twenty rats were randomized into a spinal fusion group (SF) (n=10) or a spinal fusion and oral simvastatin administered group (SFS) (n=10). A spinal fusion was performed between L4-L6 representing two levels. Simvastatin (120 mg/kg/day) was administered orally in the SFS group. The rats were killed at the end of the 12 week study period. Results: Manual palpation revealed two moderate fusions in the SF group. …

Effect Of Extracellular Matrix (Ecm) Protein Micropatterns On The Behavior Of Human Neuroblastoma Cells, Ishwari Poudel

Department of Engineering Mechanics: Dissertations, Theses, and Student Research

Recent advances in patterning techniques and emerging surface microtechnologies have allowed cell micropatterning to control spatial location of the cells on a surface as well as cell shape, attachment area, and number of contacting neighbor cells. These parameters play important roles in cell cellular behaviors. Cell micropatterning has thus become one of the most important strategies for biomedical applications, such as, tissue engineering, diagnostic immunoassays, lab-on-chip devices, bio-sensing, etc., and cell biology studies as well. For neuronal cells, there have been attempts to distribute neuronal cells on specific patterns to control cell-to-cell interaction. However, there have been very limited understanding …

Access|Closure Balloon Catheter Redesign Project, Keenan Bamburg, Yvette Castillo, Elizabeth Eskildsen

Mechanical Engineering

No abstract provided.

Challenger J Hockey Prosthesis Final Design Report, Ryan Bakker, Spencer Noe, Christopher Perkins

Mechanical Engineering

The content of this report is withheld as confidential. QL+ is the owner of the intellectual property created throughout the duration of this project. Dr. Tom Mase (mechanical engineering) maintains a full copy of the report and intends to disseminate it upon completion of the necessary intellectual property protection measures.

Golf Prosthesis Final Design Report, Joseph Barcus, Lauren Wilson, Ryan Satcher

Mechanical Engineering

A prosthetic attachment designed to allow an upper extremity bilateral amputee to golf.

Ros-Drill Automation: Visual Feedback Control And Rotational Motion Tracking, Jhon F. Diaz

Master's Theses

ICSI (intra-cytoplasmic sperm injection) has attracted research interest from both biological and engineering groups. The technology is constantly evolving to perform this procedure with precision and speed. One such development is the contribution of this thesis. We focus on a relatively recent procedure called Ros-Drill^© (rotationally oscillating drill), of which the early versions have already been effectively utilized for the mice. In the first part, we present a procedure to automate a critical part of the operation: initiation of the rotational oscillation, Visual feedback is used to track the pipette tip. Predetermined species-specific penetration depth is successfully utilized …

Variability Of Strain And Strain Rate In The Human Tibial Diaphysis During Walking, Tyler Franklin Rooks

Boise State University Theses and Dissertations

With the prevalence of stress fractures in the military and athletes of all levels, research into the pathology of this injury has taken flight in recent years. One area of research has focused on the role bone strain, which is known to be a factor in bone remodeling, has on stress fracture development. It has been difficult to perform studies in this area of research due to the invasiveness of in vivo measurements of the bone strain. Recently, a methodology for approximating the bone strain using a computational model was proposed by Al Nazer et al. (Al Nazer et al., …

Rock-N-Bowler Ii, Josh Grip, Travis Rodrigues, Richard Rozporka

Mechanical Engineering

The report of the creation of an adaptive bowling device designed for people in powered wheelchairs. The basic design is a ramp that attaches to the wheelchair and has the ability to add spin to the ball to allow the user to hook the ball.

Poroelastic Finite Element Analysis Of A Heterogeneous Articular Cartilage Explant Under Dynamic Compression In Abaqus, Kelsey Kiyo Kam

Master's Theses

A poroelastic finite element model of a heterogeneous articular cartilage disc was

created to examine the tissue response to low amplitude (± 2% strain), low

frequency (0.1 Hz) dynamic unconfined compression (UCC). A strong correlation

has been made between the relative fluid velocity and stimulation of

glycosaminoglycan synthesis. A contour plot of the model shows the relative fluid

velocity during compression exceeds a trigger value of 0.25 μm/s at the radial

periphery. Dynamic UCC biochemical results have also reported a higher

glycosaminoglycan content in this region versus that of day 0 specimens. Fluid

velocity was also found not to be …

Gas Embolic Factors In Cardiovascular Health, Eric L. Cutler

Department of Mechanical and Materials Engineering: Dissertations, Theses, and Student Research

Gas emboli are a clinical issue often encountered in the space exploration, marine construction, and medical fields.  Individuals involved with these disciplines will often have asympomatic gas emboli circulating throughout their bodies on a regular basis.  A study into the impact of chronic asymptomatic gas emboli on the risk of atherosclerosis in humans is thus presented.  This research utilized a custom built cardiovascular flow simulator and accompanying data acquisition system to experimentally determine the influence of gas emboli under varied circumstances on the mean wall shear stress of a tube in-vitro.  A directly inverse relationship between gas embolus presence in …