Biomechanical Engineering Commons^™

Selective Bacterial Biofilm Removal Using Image-Guided Detection And Cold Atmospheric Pressure Plasma, Michael Okebiorun

Boise State University Theses and Dissertations

This dissertation explores the use of cold atmospheric pressure plasma (CAP) technology in eradicating bacterial biofilms from tissue surfaces, using Ps. fluorescens on chicken tissue to model human chronic wounds. It introduces a novel image-guided technique for precise biofilm removal, employing trypan blue staining coupled with advanced computer vision analysis, enhancing the CAP treatment's precision and efficacy. The study demonstrates the CAP device's ability to effectively disrupt biofilms through a non-thermal mechanism, based on its electrical characteristics and operational parameters. The success of the treatment is evident in the significant reduction of biofilm thickness of 49 -185 µm, with the …

Using Dynamic In Vivo Kinematics For Subject-Specific Calibration Of Knee Ligament Parameters, Stephen Nelson

Boise State University Theses and Dissertations

In vivo clinical studies are the optimal way to investigate the biomechanical outcomes of new prosthetic devices. This particular style of testing can be difficult and, in certain cases, unethical to perform. The testing of unproven devices, surgical techniques, and materials put patients at risk from unanticipated outcomes in how these devices respond to the in vivo environment and patient-specific loading conditions. Biomechanical computational models were developed to provide validation to new devices prior to clinical testing. Computational models for use in optimizing knee prosthetics frequently include ligament representations, but these representations have inherent uncertainty due to wide intersubject variation …

Constitutive Modeling Of Force-Controlled Fatigue Testing In Human Meniscus Tissue, Bradley Scott Henderson

Boise State University Theses and Dissertations

The meniscus is a wedge-shaped fibrocartilaginous tissue located between the femur and tibia that helps stabilize the knee and protect the underlying cartilage. There are 2.5 million reported knee injuries each year, making it the most injured joint in the human body. Nearly twenty percent of these injuries are due to a torn meniscus, leading to over half a million meniscus surgeries performed in the United States annually. Therefore, it is critical to understand the failure modes of meniscus tissue to prevent these debilitating injuries. A failure mode that accounts for one-third of all meniscus injuries is repeated exposure to …

In Vitro Method To Quantify And Visualize Volumetric Wear In Meniscus Subjected To Joint Loading Using A 3d Optical Scanner, Kate J. Benfield

Boise State University Theses and Dissertations

The menisci are fibrocartilaginous soft tissues that act to absorb and distribute load across the surface of the knee joint. As a result of mechanical wear and large repetitive loading, meniscus tissue can begin to breakdown, or degenerate. Meniscus degeneration increases the risk of tearing, weakened tissue integrity, and the progression of osteoarthritis. Therefore, it is imperative to understand the wear behavior of whole human meniscus to identify conditions that may significantly increase the risk of degeneration.

The objective of this study is to develop and validate an in vitro methodology for characterizing volumetric wear behavior in whole human meniscus …

Isolated Nucleus Stiffens In Response To Low Intensity Vibration, Joshua Newberg

Boise State University Theses and Dissertations

The nucleus, central to all cellular activity, relies on both direct mechanical input and its molecular transducers to sense and respond to external mechanical stimuli. This response occurs by regulating intra-nuclear organization that ultimately determines gene expression to control cell function and fate. It has long been known that signals propagate from an extracellular environment to the cytoskeleton and into nucleus (outside-in signaling) to regulate cell behavior. Emerging evidence, however, shows that both the cytoskeleton and the nucleus have inherent abilities to sense and adapt to mechanical force, independent of each other. While it has been shown that isolated nuclei …

Factors Affecting Patellar Mechanics And Bone Strain In Patients With Crouch Gait, Erika Ramirez

Boise State University Theses and Dissertations

Crouch gait is a musculoskeletal impairment that results in higher than normal stresses at the patellofemoral (PF) joint that can lead to instances of anterior knee pain and loss of ambulation. The impact of commonly implemented surgical procedures to correct for crouch gait can be quantified by evaluating stresses and underlying patellar bone strain during a gait cycle. The aims of this thesis work were (1) to analyze changes in PF mechanics and patellar bone strain between pre- and postoperative conditions; (2) to quantify the variability of predicted patellar strain due to different kinematic/loading profiles or patellar material properties; and …

Variability Of Strain And Strain Rate In The Human Tibial Diaphysis During Walking, Tyler Franklin Rooks

Boise State University Theses and Dissertations

With the prevalence of stress fractures in the military and athletes of all levels, research into the pathology of this injury has taken flight in recent years. One area of research has focused on the role bone strain, which is known to be a factor in bone remodeling, has on stress fracture development. It has been difficult to perform studies in this area of research due to the invasiveness of in vivo measurements of the bone strain. Recently, a methodology for approximating the bone strain using a computational model was proposed by Al Nazer et al. (Al Nazer et al., …

Biomechanical Evaluation Of Glenohumeral Joint Stabilizing Muscles During Provocative Tests Designed To Diagnose Superior Labrum Anterior-Posterior Lesions, Vanessa J. C. Wood

Boise State University Theses and Dissertations

Despite considerable advances in the understanding of glenohumeral (GH) biomechanics and glenoid labral pathologies, arthroscopy remains the only definitive means of Superior Labrum Anterior-Posterior (SLAP) lesion diagnosis. Unfortunately, natural GH anatomic variants limit the reliability of radiography. Accurate clinical diagnostic techniques would be advantageous due to the invasiveness, patient risk, and financial cost associated with arthroscopy. Twenty provocative tests designed to elicit labral symptoms as a diagnostic sign have shown promising accuracy by their respective original authors, but later studies generally fail to reproduce those findings. The purpose of this study was to compare the behavior of GH joint stabilizing …