Biomechanical Engineering Commons^™

Effects Of Imu Sensor Location And Number On The Validity Of Vertical Acceleration Time-Series Data In Countermovement Jumping, Dianne Althouse

All Graduate Plan B and other Reports

Many devices are available for measuring the height of a CMJ. An inertial measurement unit (IMU) measures linear acceleration, orientation, and angular velocity. As an alternative to using IMU estimates of flight time, CMJ height could be estimated by integrating the IMU time-series signal for vertical acceleration to derive CMJ take-off velocity in order to track whole-body center of mass (WBCoM) movement, yet this approach would require valid IMU acceleration data. Thus, the purpose of this study was to quantify the effects of IMU sensor location and number on the validity of vertical acceleration estimation in CMJ. Thirty young adults ...

The Influence Of Flow Mechanotransduction On Endothelial Cells In The Lymphatic Valve Sinus, Joshua Daniel Hall

Doctoral Dissertations

Fluid flow in the cardiovascular and lymphatic systems influences the phenotype of endothelial cells that line the interior to the vessel via mechanotransduction. Geometric features in a vessel such as curvature, bifurcation, and valves promote heterogeneous fluid flow profiles, inducing a heterogeneous endothelial phenotype within a vessel region. Certain flow conditions are associated with vascular dysfunction, and diseases such as atherosclerosis preferentially develop in areas of flow disturbance. Lymphatic vessels are highly analogous to blood vessels, although lymphatic flow characteristics and its effect on lymphatic endothelial cells (LECs) via mechanotransduction have been comparatively less examined. The most significant geometric features ...

Developing New Crutch Tip Design For Overall Increased Stability And Improved Movement On Different Terrains, Lauren Skinner

Honors Theses

Crutches are a mobility assistive device that are often used in various situations, such as post- surgical rehabilitation and recovery after injury. The current crutch tip design that is used on today’s crutches are often unstable and do not provide quality movement on different terrains, such as snow, ice, mud, and wet surfaces. These problems would be solved with a new tip design that could be attached to existing crutches or manufactured with the crutch itself. The team’s solution to this problem is a crutch tip with modular parts. The tip would attach to the shaft of the ...

Efficient Energy Harvesting With Applications In Vibration And Implantable Biosensors, Mohammad Atmeh

Mechanical Engineering Theses

The world has stepped into the fourth industrial revolution in many ways such as using the internet of things (IoT) in various applications, and removing the rechargeable power sources seeking for batteryless systems. Since energy is widely abundant around us and it is going to waste, numerous of recent studies have been conducted to propose sustainable solutions to harvest the free ambient power from the surrounding and convert it into electricity. Heat energy, kinetic energy, and radio waves are examples of these potentially harvestable energy sources. Mechanical vibrations represent one of the most plentiful forms of kinetic energy that can ...

Corrosion Assessment Of Biodegradable Metal Implants For Orthopedic Applications, Wendy B. Reynoso-Diaz

Honors Theses

Magnesium alloys are the most promising materials to be used as biodegradable implants mainly due to their superior biocompatibility and lower specific density compared to other biodegradable metals (i.e., zinc and iron-based alloys). This study is investigating the effect of two different manufacturing methods and purity levels on the corrosion rates of a novel Mg-Zn-Ca-Mn-based alloy. Experimental in vitro corrosion tests were conducted on the biocompatible Mg-Zn-Ca-Mn-based alloy fabricated using conventional casting and hot rolling with low and high purity levels. The experimental research conducted, assessed the corrosion rates of the following Mg-1.2Zn-0.5Ca-0.5Mn-based alloys: Hot Rolled ...

Atomic Force Microscopy Based Dna Sensing And Manipulation, Matthew Shubert

Mechanical Engineering Undergraduate Honors Theses

Sequencing DNA provides a positive impact for the biomedical community by understanding a wide variety of applications such as human genetics, disease, and pathogens. The reason the Arkansas Micro & Nano Systems lab is involved with research in DNA sequencing is due to the current, leading industry method. Nanopore sequencing was developed by Oxford Nanopore Technology in which its sequencing method separates double stranded DNA to electrically characterize individual nucleotides traveling through a charged nanopore. Unfortunately, nanopore sequencing uses biological materials that require a shelf life and drives high cost. Therefore, the Arkansas Micro & Nano Systems lab has developed a DNA ...

Development And Application Of 3d Kinematic Methodologies For Biomechanical Modelling In Adaptive Sports And Rehabilitation, Anne Marie Severyn

All Dissertations

Biomechanical analysis is widely used to assess human movement sciences, specifically using three-dimensional motion capture modelling. There are unprecedented opportunities to increase quantitative knowledge of rehabilitation and recreation for disadvantaged population groups. Specifically, 3D models and movement profiles for human gait analysis were generated with emphasis on post-stroke patients, with direct model translation to analyze equivalent measurements while horseback riding in use of the alternative form of rehabilitation, equine assisted activities and therapies (EAAT) or hippotherapy (HPOT). Significant improvements in gait symmetry and velocity were found within an inpatient rehabilitation setting for patients following a stroke, and the developed movement ...

Finite Element Model Of The Pediatric Hip Joint During The Barlow Maneuver, Christina M. Zlock

PhD Dissertations and Master's Theses

Developmental Dysplasia of the Hip is the dysplasia or dislocation of an unstable femoral head in the acetabulum of the pelvis. This is a result of an abnormal or underdeveloped growth of the acetabulum and triradiate cartilages and/or an out of place and uncentered femoral head in the acetabulum. This underdevelopment, if not diagnosed and treated at an early age, may lead to abnormal and pain and osteoarthritis later in life. A common step in diagnosis is to perform a physical examination of the hip, one method is the Barlow maneuver.

The aim of the project is to use ...

Design And Computational Validation Of A Shear Stress Bioreactor For Conditioning Vascular Tissue To Time-Varying Multidirectional Fluid Shear Stress, Rajeshwari Raja, Philippe Sucosky, Jason Shar

Symposium of Student Scholars

Design and Computational Validation of a Shear Stress Bioreactor for Conditioning Vascular Tissue to Time-Varying Multidirectional Fluid Shear Stress

Author: Rajeshwari Raja Mentor: Dr. Jason A. Shar Department of Mechanical Engineering Kennesaw State University 1100 South Marietta Pkwy SE, 30060

Altered biological environments and conditions, such as microgravity and pregnancy, can impact vascular blood flow and, in turn, generate fluid wall shear stress (WSS; frictional force generated on the tissue surface due to blood flow) abnormalities. These abnormalities are known to affect cardiovascular tissue biology and can be replicated experimentally using a cone-and-plate shear stress bioreactor. This device exposes tissue ...

A Meshless Approach To Computational Pharmacokinetics, Anthony Matthew Khoury

PhD Dissertations and Master's Theses

The meshless method is an incredibly powerful technique for solving a variety of problems with unparalleled accuracy and efficiency. The pharmacokinetic problem of transdermal drug delivery (TDDD) is one such topic and is of significant complexity. The locally collocated meshless method (LCMM) is developed in solution to this topic. First, the meshless method is formulated to model this transport phenomenon and is then validated against an analytical solution of a pharmacokinetic problem set, to demonstrate this accuracy and efficiency. The analytical solution provides a locus by which convergence behavior are evaluated, demonstrating the super convergence of the locally collocated meshless ...

Characterizing Mechanical Regulation Of Bone Metastatic Breast Cancer Cells, Boyuan Liu

Doctoral Dissertations

Breast cancer most frequently metastasizes to the skeleton. Bone metastatic cancer is incurable and induces wide-spread bone osteolysis, resulting in significant patient morbidity and mortality. Mechanical stimuli in the skeleton are an important microenvironmental parameter that modulates tumor formation, osteolysis, and tumor cell-bone cell signaling, but which mechanical signals are the most beneficial and the corresponding molecular mechanisms are unknown. This work focused on bone matrix deformation and interstitial fluid flow based on their well-known roles in bone remodeling and in primary breast cancer. The goal of our research was to establish a platform that could define the relationship between ...

Reducing Loading On The Contralateral Limb Using Human-In-The-Loop Optimization, Siena Senatore

Student Research and Creative Activity Fair

In most everyday activities, we head towards a specific goal by updating our choices for a more direct path. However, there are specific clinical tasks where taking the direct path is more challenging. Clinical investigations of optimizing a prosthesis involve the assessment of multiple parameter settings through trial and error rather than goal-directed optimization. We investigate if a human-in-the-loop optimization algorithm can guide manual alterations to a prosthesis-simulating device to reduce the ground reaction force on the contralateral limb. In most participants, the optimal condition reduced the loading rate on the contralateral limb compared to the initial condition tested. These ...

The Optimal Relationship Between Actuator Stiffness And Actuation Timing For A Passive Ankle Exoskeleton: An Opensim Simulation, Cody Anderson, Hafizur Rahman, Sara Myers

Student Research and Creative Activity Fair

Introduction

The passive ankle exoskeleton developed by Collins et al. (2015) reduced the metabolic cost of walking with an actuation-timing of ~16% of stance [1]; however, other actuation timings have not been extensively investigated. Therefore, the purpose of this study was to determine the optimal relationship between actuator-stiffness and actuation-timing for a passive ankle exoskeleton by using musculoskeletal modeling.

Methods

Kinematics and ground reaction forces were recorded while a healthy-young male walked on overground force-plates, and these data were exported to a musculoskeletal modeling software (OpenSim) for simulation. A passive ankle exoskeleton model was designed and integrated with a default ...

The Role Of Transient Vibration Of The Skull On Concussion, Rodrigo Dalvit Carvalho Da Silva

Electronic Thesis and Dissertation Repository

Concussion is a traumatic brain injury usually caused by a direct or indirect blow to the head that affects brain function. The maximum mechanical impedance of the brain tissue occurs at 450±50 Hz and may be affected by the skull resonant frequencies. After an impact to the head, vibration resonance of the skull damages the underlying cortex. The skull deforms and vibrates, like a bell for 3 to 5 milliseconds, bruising the cortex. Furthermore, the deceleration forces the frontal and temporal cortex against the skull, eliminating a layer of cerebrospinal fluid. When the skull vibrates, the force spreads directly ...

Mechanical Horse Project, Hernan Ramirez Resendiz, Ben Apt

Mechanical Engineering

This document outlines our senior design project for the Cal Poly Mechanical Engineering Department on behalf of Jack’s Helping Hand. As a team of two Mechanical Engineering students, we developed a structure that can support a rider and can move in three degrees of freedom to model the gait patterns of a horse. This senior project will be continued by another group that will focus on electronics and implement the motors that will induce motion on the structure that our team has built. We collected baseline data by attaching an iPhone to a horse and used that motion to ...

The Influence Of Frontal And Axial Plane Deformities On Contact Mechanics During Squatting: A Finite Element Study, Yidan Xu

Electronic Thesis and Dissertation Repository

Knee Osteoarthritis (KOA) is a degenerative joint disease and a leading cause of disability worldwide. Lower limb malalignment was a risky factor leading to KOA, altering the load distributions. This study aimed to study the influence of knee deformities on knee contact mechanics and knee kinematics during squatting. A full-leg squat FE model was developed based on general open-source models and validated with in vivo studies to investigate the outputs under frontal malalignment (valgus 8° to varus 8°) and axial malalignment (miserable malalignment 30°). As a result, Varus-aligned and miserable aligned models increased medial tibiofemoral force and lateral patellar contact ...

Improving Quantification Of Mitral Regurgitation Through Computational Fluid Dynamics And Ex Vivo Testing, Alexandra Flowers

Electronic Theses and Dissertations

Mitral regurgitation (MR) is a prominent cardiac disease affecting more than two million people in the United States alone. In order for patients to receive proper therapy, regurgitant volume must first be quantified. As there are an array of methods to do so, the proximal isovelocity surface area (PISA) method continues to be the most accurate and clinically used method. However, there are some difficulties obtaining the necessary measurements need for this when performing transthoracic echocardiography. This study aims to evaluate and present techniques that may be used to more accurately quantify regurgitation through ex vivo testing and computational fluid ...

Modeling Human Control Behavior In Command-Following Tasks, Sajad Koushkbaghi

Theses and Dissertations--Mechanical Engineering

Humans interact with a variety of complex dynamic systems on a daily basis. However, they are often the lesser understood component of human-in-the-loop (HITL) systems. In this dissertation, we present the results of two HITL experiments to investigate the control strategies that humans use when performing command-following tasks. The first experiment is designed to investigate the control strategies that humans use to interact with nonlinear dynamic systems. Two groups of human subjects interact with a dynamic system and perform a command-following task. One group interacts with a linear time-invariant (LTI) dynamic system and the other group interacts with a Wiener ...

Antagonistic Co-Contraction Can Minimize Muscular Effort In Systems With Uncertainty, Anne D. Koelewijn, Antonie J. Van Den Bogert

Mechanical Engineering Faculty Publications

Muscular co-contraction of antagonistic muscle pairs is often observed in human movement, but it is considered inefficient and it can currently not be predicted in
simulations where muscular effort or metabolic energy are minimized. Here, we investigated the relationship between minimizing effort and muscular co-contraction
in systems with random uncertainty to see if muscular co-contraction can minimize effort in such system. We also investigated the effect of time delay in the muscle, by varying the time delay in the neural control as well as the activation time constant.We solved optimal control problems for a one-degree-of-freedom pendulum actuated by two ...

Numerical Design Of Steerable Guidewires, Onkar Prakash Salunkhe

Dissertations, Master's Theses and Master's Reports

Biomedical devices are an integral part of the medical industry nowadays. With the increase in cases of heart disease, catheterization procedures are becoming more frequent. Small-scale actuators are needed for the guidance of small-scale catheters and guidewires to remote targets in the human body. Numerical modelling is needed to guide the experiments in developing such steerable devices and to optimize their design. Here, we designed small-scale steerable guidewires by first developing bending actuators and then assembling them with guidewires. The actuators use materials with strain response to electric potential in a very low voltage range that is not harmful to ...