Biomechanical Engineering Commons^™

Borophene And Graphene For Non-Enzymatic Biosensor- Ab-Initio Study, Omar A. Ismail

Theses and Dissertations

Non-enzymatic glucose sensing holds promise to overcome limitations associated with glucose oxidase, such as oxygen dependence and short shelf life. This study explores the potential sensing capabilities of borophene and graphene through direct interaction with various compounds, including β-glucose, uric acid, ascorbic acid, fructose, and acetaminophen. Using Density Functional Theory (DFT), we calculated binding energies and the respective Density of States (DOS) for these adsorbates on both graphene and borophene surfaces. Preliminary results suggest that borophene might exhibit nearly twice the affinity for β-glucose compared to graphene. Moreover, the calculated Density of States reveals distinct distortions in the electronic states …

Air-Jet Bioprinting Of Stem Cell-Encapsulated Alginate Micro-Droplets For Organoid Biomanufacturing, Mirabella B. Stump

Electronic Theses and Dissertations

Biomanufactured 3D-organoids show promise for modeling and treating various conditions, particularly insulin-dependent diabetes mellitus (type-1 diabetes). Pancreatic islet organoids serve as sustainable sources of insulin-producing β-cells, potentially restoring insulin regulation in patients and providing a long-term solution for diabetes. Hydrogel droplet printing is an emerging technique in regenerative medicine due to its advantageous tunability and biocompatibility; however, challenges of consistency, quality control, and scalability persist. To address these issues, we developed a novel air-jetting based droplet bioprinting system for the generation of monodispersed alginate micro-droplets. The objective of this project was to incorporate human induced pluripotent stem cells (hiPSCs) into …

Computational Modeling Using A Novel Continuum Approach Coupled With Pathway-Informed Neural Networks To Optimize Dynein-Mediated Centrosome Positioning In Polarized Cells, Arkaprovo Ghosal, Padmanabhan Seshaiyar Dr., Adriana Dawes Dr., General Genomics Inc.

Annual Symposium on Biomathematics and Ecology Education and Research

No abstract provided.

Changes In Balance With Brain Inflammation: Sensitivity In Dual Motor Mechanisms, Hannah Mcdade

Electronic Theses and Dissertations

Concussion assessment in athletes has gained prominence due to potential long-term consequences of traumatic brain injuries. Evaluating balance alterations is crucial for understanding post-injury motor control strategies. This study introduces a novel approach to understanding center of pressure (COP) dynamics during quiet stance tasks for assessing balance impairments in athletes recovering from concussion. Concussed athletes often experience impaired motor function and cognitive deficits, increasing the risk of orthopedic injury. Traditional balance assessments focus on total COP (COPt), overlooking nuanced hip and ankle mechanisms. This research investigates COP variations between constant loading (COPc) and variable loading (COPv) signals in concussed athletes …

Kinematic Analysis Of Gait And Deep Knee Flexion For Pre- And Post-Operative Total Knee Arthroplasty, Samantha Collins

Electronic Theses and Dissertations

Osteoarthritis (OA) is a form of arthritis that develops in the joint due to overuse and aging causing pain, discomfort, and disability. Total Knee Arthroplasty (TKA) is a surgical procedure performed when OA symptoms are severe with an estimated 600,000 patients in the United States currently receiving TKA. Studies have reported dissatisfaction of the knee for 14-39% of patients. This study collected knee kinematics before and after surgery using stereo radiography for precise measurement of gait and deep knee flexion activities. Results showed healthy knee kinematics were not restored and no significant changes could be seen from OA kinematics in …

Exploration Of Motion Capture System To Investigate Human Shoulder Kinematics, Ola Alsaadi

Electronic Theses and Dissertations

The glenohumeral joint (GH) is commonly conceptualized as a ball-and-socket joint [1], and its center of rotation (COR) is presumed to coincide with the geometric center of the medial-superior region of the humeral head [2]. Recent research has endorsed improvements in COR estimation through invasive and noninvasive techniques, including cadaver studies, stereophotogrammetry, and motion capture (MOCAP) systems. Despite increased interest in wearable technology within human movement analysis, the problem of COR estimation employing MOCAP systems and its validation against bi-planar fluoroscopy remains relatively unexplored.

This study employed a marker-based MOCAP system to compare the accuracy, error, and precision of three …

Computational Methodology For Generating Patient-Specific Soft Tissue Representations, Ahilan Anantha Krishnan

Electronic Theses and Dissertations

This dissertation focused on modeling specimen-specific soft tissue structures in the context of joint replacement surgery. The research addressed four key aspects. The first study involved developing a workflow for creating finite element models of the hip capsule to replicate its torque-rotational response. Experimental data from ten cadaveric hips were used to calibrate the models, resulting in improved accuracy and relevance for surgical planning and implant design. The second study tackled the challenge of expediting the calibration of mechanical properties of the hip capsule to match patient-specific laxities. A statistical shape function model was proposed to generate patient-specific finite element …

Digital Twins Of The Living Knee: From Measurements To Model, Thor Erik Andreassen

Electronic Theses and Dissertations

Modern medicine has dramatically improved the lives of many. In orthopaedics, robotic surgery has given clinicians superior accuracy when performing interventions over conventional methods. Nevertheless, while these and many other methods are available to ensure treatments are performed successfully, far fewer methods exist to predict the proper treatment option for a given person. Clinicians are forced to categorize individuals, choosing the best treatment on “average.” However, many individuals differ significantly from the “average” person, for which many of these treatments are designed. Going forward, a method of testing, evaluating, and predicting different treatment options' short- and long-term effects on an …

Analysis Of Gait Parameters And Knee Angles In Ultimate Frisbee Players: Implications For Balance And Injury, Ethan Nikcevich

Master's Theses

Biomechanics research investigating gait and balance of ultimate frisbee players is an unexplored topic. Ultimate requires a wide range of motions that could improve balance and is also a sport prone to frequent injury. This study explores the impact of playing ultimate on gait parameters associated with balance and knee angles associated with joint injury. Gait trials were conducted on 8 ultimate players and 8 control participants between the ages of 18 and 23 to obtain total double support time, stance phase time, single support time, load response time, abduction-adduction (AA) angles, internal-external (IE) rotation angles, and flexion angles of …

Exoskeletons - Designing For Social Justice, Grace Cd Murphy

College of Engineering Summer Undergraduate Research Program

Many engineering professionals believe that discussions surrounding diversity, equity, and inclusion (DEI), and social justice do not belong in engineering because engineering is supposed to be a neutral or objective field. Through an extensive review of the literature and a survey sent out to potential users, the need for DEI in engineering was examined. Many current engineering projects do not take into consideration social justice principles which leaves certain groups further marginalized and disempowered while empowering a select few. Engineering has the opportunity to be a field of service, but first risks and benefits must be weighed and the outcome …

Machine Learning Approach To Activity Categorization In Young Adults Using Biomechanical Metrics, Nathan Q. C. Holland

Mechanical & Aerospace Engineering Theses & Dissertations

Inactive adults often have decreased musculoskeletal health and increased risk factors for chronic diseases. However, there is limited data linking biomechanical measurements of generally healthy young adults to their physical activity levels assessed through questionnaires. Commonly used data collection methods in biomechanics for assessing musculoskeletal health include but are not limited to muscle quality (measured as echo intensity when using ultrasound), isokinetic (i.e., dynamic) muscle strength, muscle activations, and functional movement assessments using motion capture systems. These assessments can be time consuming for both data collection and processing. Therefore, understanding if all biomechanical assessments are necessary to classify the activity …

Modeling The Moisture Content And Drying Rate Of Zucchini (Cucurbita Pepo L.) In A Solar Hybrid Dryer Using Ann And Anfis Methods, Halil Nusret Bulus, Aytac Moralar, Soner Celen

The Philippine Agricultural Scientist

Estimating product drying kinetics is critical to obtain the best drying process without compromising product quality and necessitates the development of numerical drying models. This research aims to compare the prediction models developed using artificial neural network (ANN) and adaptive network-based fuzzy inference system (ANFIS), two popular machine learning approaches in the recent years. Zucchini slices were chosen as samples and dried in a solar-assisted microwave belt dryer at 0.245 m/min belt speed and microwave powers of 0.7, 1, and 1.4 kW. On the data set obtained by computing the moisture content and drying rate values, prediction models were developed …

Quantifying Balance: Computational And Learning Frameworks For The Characterization Of Balance In Bipedal Systems, Kubra Akbas

Dissertations

In clinical practice and general healthcare settings, the lack of reliable and objective balance and stability assessment metrics hinders the tracking of patient performance progression during rehabilitation; the assessment of bipedal balance plays a crucial role in understanding stability and falls in humans and other bipeds, while providing clinicians important information regarding rehabilitation outcomes. Bipedal balance has often been examined through kinematic or kinetic quantities, such as the Zero Moment Point and Center of Pressure; however, analyzing balance specifically through the body's Center of Mass (COM) state offers a holistic and easily comprehensible view of balance and stability.

Building upon …

Improving Irrigant Flow Characteristics For Enhanced Root Canal Therapy: A Numerical Study, Bibek Banjaday

Masters Theses

This numerical study investigates the flow characteristics within a root canal during a manual endodontic treatment. To underscore the difference in root canal geometry, a simplified root canal (frustum of a cone) and a more complex (realistic) root canal geometry were considered. The needle utilized in all simulations is a side-vented 30G KerrHaweIrrigation Probe, KerrHawe SA, Bioggio, Switzerland. For both root canal geometries, the effect of variation of fluid inlet velocity, needle insertion depth, and needle tilt angle on flow characteristics was examined via velocity contours, turbulent intensity, wall shear stress, and streamline and vector plots. The fluid was Sodium …

Enhancing Human Key Point Identification: A Comparative Study Of High-Resolution Vicon Dataset And Coco Dataset Using Bpnet, Bibash Lama

Masters Theses

Accurately identifying human key points is crucial for various applications, including activity recognition, pose estimation, and gait analysis. This study presents a high-resolution dataset created using the VICON motion capture system and three differently oriented 2D cameras, that can be used to train different neural networks for estimating the 2D key joint positions of the person from the 2D images or videos. The participants in the study included 25 healthy adults (17 males and 8 females) performing normal gait movements for about 2 to 3 seconds. The VICON system captured 3D ground truth data, while the three 2D cameras collected …

Hierarchical Based Classifcation Method Based On Fusion Ofgaussian Map Descriptors Foralzheimer Diagnosis Using T1‑Weighted Magnetic Resonance Imaging, Nourhan Zayed, Shereen E. Morsy, Inas A. Yassine

Mechanical Engineering

Alzheimer’s disease (AD) is considered one of the most spouting elderly diseases. In 2015, AD is reported the US’s sixth cause of death. Substantially, non-invasive imaging is widely employed to provide biomarkers supporting AD screening, diagnosis, and progression. In this study, Gaussian descriptors-based features are proposed to be efcient new biomarkers using Magnetic Resonance Imaging (MRI) T1-weighted images to diferentiate between Alzheimer’s disease (AD), Mild Cognitive Impairment (MCI), and Normal controls (NC). Several Gaussian map-based features are extracted such as Gaussian shape operator, Gaussian curvature, and mean curvature. The aforementioned features are then introduced to the Support Vector Machine (SVM). …

Multi-Objective Design Optimization Of Two Configurations Of Ventricular Shunts For Hydrocephalus, Will Kirkpatrick

Theses and Dissertations

Hydrocephalus is developed when the flow of cerebrospinal fluid is obstructed in the ventricles and a pressure build-up is generated within the brain. Ventricular shunts are used to remove excess fluid from the brain, but these shunts have a common problem of failure due to the shunt being obstructed by the build-up of astrocytes. To address this, two sets of 27 designs of ventricular shunts were identified and analyzed with parameters that could potentially reduce obstruction risks. The performance of these designs was examined using fluid simulations on these two sets of 27 designs. One set explored close-tipped shunt designs, …

Nanoscale Modeling Of Membrane Systems Under Mechanical Deformation In Traumatic Brain Injury Using Molecular Dynamics, Anh Thi Ngoc Vo

Theses and Dissertations

Neuronal membrane disruption and mechanoporation are nanoscale damage mechanisms that critically affect brain cell viability during traumatic brain injury (TBI). These nanoscale cellular impairments are elusive in experiments and necessitate in silico approaches such as molecular dynamics (MD) simulations. Implementing MD, this research aims to investigate the effects of different key factors related to membrane deformation and damage, including force field resolutions, lipid compositions, and loading conditions.

To examine the impact of force field resolution, MD deformation simulations were conducted on 1-palmitoyl-2-oleoyl-sn-glycero-3-phosphatidylcholine (POPC) lipid bilayer membranes, using all-atom (AA), united-atom (UA), and coarse-grained Martini (CG-M) force fields. The mechanical responses …

Hemodynamic Assessment Of Y-Incision Aortic Root Enlargement Using Computational Simulations, Astitwa Ghimire

Electronic Theses and Dissertations

The Yang procedure is a new aortic root enlargement technique used to enlarge the aortic annulus by multiple valve sizes. The procedure prevents patient prosthesis mismatch and establishes a viable platform for future valve-in-valve implantation. This study used the Yang procedure to investigate the hemodynamics in the aortic root and bioprosthetic valve regions after aortic root enlargement. Results indicate the velocity magnitude at the sinus regions of a patient who underwent the Yang procedure was slower, indicating risks of flow stasis and thrombosis. Simulation results denote computational models can be created for optimization of surgical procedures.

Finite Element Modeling Of Patient-Specific Total Shoulder Arthroplasty, Ignacio Rivero Crespo

Electronic Theses and Dissertations

Total Shoulder Arthroplasty (TSA) is a surgical procedure designed to improve joint functionality by replacing the articulation between the humeral head and the glenoid fossa. Anatomic Total Shoulder Arthroplasty (aTSA) and Reverse Total Shoulder Arthroplasty (rTSA) are two types of replacement surgery to relieve pain and restore function of the shoulder. The overall goal of this study was to evaluate the effects of variation of certain patient and implant alignment parameters that may influence long-term outcomes of these surgical procedures, including kinematics, joint loads and contact mechanics. Computational models of six TSA subjects, three aTSA and three rTSA, were created …

A Virtual Method For Establishing Femoral Stem Position In Total Hip Arthroplasty, Samuel Mattei

Electronic Theses and Dissertations

Total hip arthroplasty (THA) is one of the most successful orthopedic surgeries performed, in which the hip joint is reconstructed to improve functionality and decrease pain in the joint. Despite the success of these procedures, femoral stem misalignment remains an area that influences THA success. The relationship between the femoral stem geometry and implanted femoral stem size and orientation is underreported due to limitations in the collection of radiographic data used for clinical pre-operative templating. Furthermore, the influence of anatomic measurements on the direction and size of the femoral stem are not considered due to imaging technique and difficulties associated …

Extrusion Of Uniform-Diameter Polyetheretherketone-Magnesium Phosphate Bio-Composite Filaments For 3d Printing Of Design-Specific Multi-Functional Implants, Vijay K. Bokam, Surendrasingh Y. Sonaye, Phaniteja Nagaraju, Harsha P.S. Naganaboyina, Prabaha Sikder

Mechanical Engineering Faculty Publications

Polyetheretherketone (PEEK) is a high-performance polymer material for developing implants for orthopedic, spinal, cranial, maxillofacial, and dentistry applications. However, the major limitation of PEEK implants is their bioinertness, i.e., their incapability to integrate with tissues. Therefore, prior efforts have always focused on developing hydroxyapatite (HA) coatings on PEEK or PEEK-HA composites. However, in this study, we engineered a highly novel bioceramic known as amorphous magnesium phosphate (AMP), which surpasses the bioactivity and biodegradation kinetics of HA. Subsequently, we incorporated AMP in PEEK to develop a unique PEEK-AMP bioactive composite in the form of uniform-diameter filaments, such that it can be …

Biomat (Biomechanics Multiactivity Transformer) Model, Mohsen Sharifi Renani

BioMAT (Biomechanics Multiactivity Transformer)

No abstract provided.

Fully Coupled Fluid Structure Interaction Simulation Of Bioprosthetic Heart Valves: A Numerical And Experimental Analysis, Masod Sadipour

Electronic Theses and Dissertations

Aortic stenosis impacts approximately 7% of the global population. In the past decade, the role of computational modeling has been becoming considerably important in the design of BHVs. To obtain reliable solutions in computational modeling, it is essential to consider accurate properties of bioprosthetic heart valves (BHVs), such as density and mechanical properties. Previous computational studies assumed (bovine pericardium) BP used in BHVs density was comparable to water or blood. Yet, BP is subjected to multiple treatments like fixation and anti-calcification. In Chapter 2, I measured BP density and its effect on BHV leaflet stress and strain. In the second …

Bespoke Bicycle Enclosure, Thomas Link, Kyle Mcafee, Marc Monier, Hunter Walden

Mechanical Engineering

Brian Higgins is an American veteran with retinitis pigmentosa who relies on cycling for transportation. The motivation for this project is to design and manufacture a refined prototype bicycle attachment to support him while biking in the rain and cold. The attachment will serve to enclose him for optimal protection from inclement weather, while maintaining sufficient mobility for daily cycling. Mr. Higgins’ bicycle is equipped with an attached sensor system which assists his visual impairment by using an ultrasonic sensor. Therefore, the attachment cannot adversely affect the function of the sensor system. The project timeline is set at approximately 7 …

Biomechanical Knee Joint For Exoskeleton, Gabriel Ireton Ahern, Calloway Miller, Christianna Altamura, Eric Mailes

Mechanical Engineering

Our senior design project consisted of designing and manufacturing a biomechanically accurate, actuated knee joint to be integrated into an exoskeleton being developed by the Lower Limb Exoskeleton Assist Project (LLEAP), a part of the EMPOWER student association at Cal Poly, San Luis Obispo. As the human knee flexes and extends throughout gait motion, the center of rotation changes. Currently marketed exoskeletons have one point of rotation, which over constrains the knee and causes misalignment between the user and the suit [1]. Our goal was to mimic natural knee joint motion by changing the center or rotation, thus reducing misalignment …

Novel Approach For Non-Invasive Prediction Of Body Shape And Habitus, Emma Young

Electronic Theses and Dissertations

While marker-based motion capture remains the gold standard in measuring human movement, accuracy is influenced by soft-tissue artifacts, particularly for subjects with high body mass index (BMI) where markers are not placed close to the underlying bone. Obesity influences joint loads and motion patterns, and BMI may not be sufficient to capture the distribution of a subject’s weight or to differentiate differences between subjects. Subjects in need of a joint replacement are more likely to have mobility issues or pain, which prevents exercise. Obesity also increases the likelihood of needing a total joint replacement. Accurate movement data for subjects with …

Patient Movement Monitoring Based On Imu And Deep Learning, Mohsen Sharifi Renani

Electronic Theses and Dissertations

Osteoarthritis (OA) is the leading cause of disability among the aging population in the United States and is frequently treated by replacing deteriorated joints with metal and plastic components. Developing better quantitative measures of movement quality to track patients longitudinally in their own homes would enable personalized treatment plans and hasten the advancement of promising new interventions. Wearable sensors and machine learning used to quantify patient movement could revolutionize the diagnosis and treatment of movement disorders. The purpose of this dissertation was to overcome technical challenges associated with the use of wearable sensors, specifically Inertial Measurement Units (IMUs), as a …

Computational Study On The Acoustic Footprint Of Stenosis In Larger Arteries, Ahmed Abdelnabi

Theses and Dissertations

We identify a new (acoustic) frequency-stenosis relations whose frequencies fall within the recommended auscultation threshold for stethoscopy (< 120 Hz) in this study. We demonstrate that these relations can be used to extend the application of phonoangiography (the measurement of the degree of stenosis from bruits) to stethoscopes that are broadly available. The First relationship is successfully identified using an analysis limited to the acoustic signature of the von Karman vortex street, which we automatically isolate using a metric based on an area-weighted average of the Q-criteria for the post-stenotic region. Specifically, we conduct LES-CFD simulations on simplified 2D internal flow geometries that represent blood vessels with varying degrees of stenosis. Then, using the Ffowcs Williams-Hawkings (FW-H) equation, we extract their emitted acoustic signals, which we subtract from a pure signal (stenosis-free) at the same heart rate. Next, we transform this differential signal to the frequency domain and meticulously classify its acoustic signatures according to six stenosis-invariant flow phases of a cardiac cycle. Using our Q-criterion-based metric, we then automatically restrict our acoustic analysis to the noises emitted by the von Karman vortex street (phase 4). Our analysis of its acoustic signature demonstrates a strong linear relationship between the degree of steno- sis and its dominant frequency, which differs significantly from the break frequency and heart rate (previously identified dominant frequencies). For the Second relationship, we develop a frequency-stenosis scaling law for particularly supravalvular aortic stenosis that falls within the preferred frequency range (30-120 Hz) for echocardiography. We expand to 3D patient specific geometry using Simulia’s Living Heart Human Model (LHHM), which has an anatomically accurate aorta geometry. This LHHM geometry is modified with stenoses ranging from 30 to 80 percent (moderate to severe). For physiologically consistent hemodynamic boundary conditions, we expand the study to employ the Windkessel model, which has been implemented on Fluent using UDF. We demonstrate that physiological boundary conditions reduce simulation time significantly compared to static boundary conditions. The FW-H model extracted the flow-generated acoustic signal of the stenotic geometries and analysed it at clinically relevant receiver locations. A preferred receiver location consistent with clinical practise is determined, and a correlation between the degree of stenosis and the prevalent acoustic frequency (within the frequency range of 70-120 Hz) is established. The obtained second scaling law is shown to be clinically reliable in assessing stenotic severity. Future research will investigate incorporating the vibroacoustic role of adjacent organs and tissue to expand the clinical applicability of our findings. Expansion of clinical and numerical datasets will be pursued in future research to enhance the reliability of our scaling law, possibly by leveraging much-needed ML-based acceleration schemes.

Flexible Magnetic Skin Sensor Array For Torsion Perception, Lucja Stawikowska, Erik D. Engeberg

Florida Conference on Recent Advances in Robotics

Prosthetic hands help upper limb amputees and people who were born without hands. Currently, these prostheses are rather rudimentary and do not provide adequate sensing capabilities compared to a human hand. People use their natural hands to perceive complex tactile phenomena such as shear and torsion using thousands of mechanoreceptors in their fingertips. The capability to detect torsional loads at the fingertips is a notable gap in prosthetic hand sensation. Flexible tactile sensors are a promising new technology that would be ideal for prosthetic hands since they allow for stretching and movement like human skin without damage to the sensor. …