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Decreased Neuroinflammation And Increased Brain Energy Homeostasis Following Environmental Enrichment After Mild Traumatic Brain Injury Is Associated With Improvement In Cognitive Function, Teresita L. Briones, Julie Woods, Magdalena Rogozinska 2013 Wayne State University

Decreased Neuroinflammation And Increased Brain Energy Homeostasis Following Environmental Enrichment After Mild Traumatic Brain Injury Is Associated With Improvement In Cognitive Function, Teresita L. Briones, Julie Woods, Magdalena Rogozinska

Wayne State University Associated BioMed Central Scholarship

Abstract

Background

Persistent neuroinflammation and disruptions in brain energy metabolism is commonly seen in traumatic brain injury (TBI). Because of the lack of success of most TBI interventions and the documented benefits of environmental enrichment (EE) in enhancing brain plasticity, here we focused our study on use of EE in regulating injury-induced neuroinflammation and disruptions in energy metabolism in the prefrontal cortex and hippocampus. Adult male Wistar rats were used in the study and randomly assigned to receive either: mild TBI (mTBI) using the controlled cortical injury model or sham surgery. Following surgery, rats from each group were further randomized …


A Trauma Unit’S Interprofessional Approach To Reducing Catheter Associated Urinary Tract Infections, Kai L. Bortz RN 2013 Lehigh Valley Health Network

A Trauma Unit’S Interprofessional Approach To Reducing Catheter Associated Urinary Tract Infections, Kai L. Bortz Rn

Patient Care Services / Nursing

No abstract provided.


Effects Of Traumatic Brain Injury On Domestic Violence Survivors, Elizabeth Marie Martin 2013 University of Northern Iowa

Effects Of Traumatic Brain Injury On Domestic Violence Survivors, Elizabeth Marie Martin

Honors Program Theses

Very little research exists on the topic of traumatic brain injury within the context of domestic violence. The purpose of this research is to increase the body of knowledge on traumatic brain injury in domestic violence survivors. More specifically, this research serves to understand the frequency of traumatic brain injury among domestic violence survivors with the subsequent foci of analyzing the relationship between traumatic brain injury and domestic violence, identifying the impact of traumatic brain injury on domestic violence survivors, and discovering strategies for serving domestic violence survivors who have sustained traumatic brain injury. A secondary data analysis of a …


Non Fatal Injuries Among Infants: A Pilot Study, Seema Zainulabdin Lasi, Ghazala Rafique, Habib Peermohammad 2012 Aga Khan University

Non Fatal Injuries Among Infants: A Pilot Study, Seema Zainulabdin Lasi, Ghazala Rafique, Habib Peermohammad

Human Development Programme

Objective: To determine the incidence, nature and the extent of infant injuries in two suburban and rural communities of Pakistan.
Methods: The cross-sectional study was conducted on a cohort of 310 infants in suburban and rural communities of Pakistan in September 2007. The information was collected from primary care-givers based on any injury that had occurred to their infants during the preceding 3 months that required treatment at home or in a hospital.
Result: The incidence of non-fatal injury for infants up to 1-year-old was found to be 19 injuries per 100 person (child) years of exposure (95% CI 9.90 …


Research Brief: "Work-Related Quality Of Life And Post-Traumatic Stress Disorder Symptoms Among Female Veterans", Institute for Veterans and Military Families at Syracuse University 2012 Syracuse University

Research Brief: "Work-Related Quality Of Life And Post-Traumatic Stress Disorder Symptoms Among Female Veterans", Institute For Veterans And Military Families At Syracuse University

Institute for Veterans and Military Families

This study focuses on post-traumatic stress disorder (PTSD) among female veterans, and found that about 10.2% of female veterans using the VA in 2009 had a diagnosis of PTSD, compared to 7.8% of their male counterparts. In practice, occupational program facilitators and health professionals should focus on creating interventions that target the needs of veterans with multiple diagnoses. For policy, policymakers should also focus on initiatives that serve both female veterans with multiple diagnoses and health professionals providing care to these veterans. Suggestions for future study include having large samples of female veterans and performing gender comparisons in data analysis, …


Under The Gun: Ongoing Assaults On Bahrain’S Health System, Richard Sollom, Holly G. Atkinson 2012 Physicians for Human Rights

Under The Gun: Ongoing Assaults On Bahrain’S Health System, Richard Sollom, Holly G. Atkinson

Publications and Research

In February 2011, the Government of Bahrain began targeting health professionals who treated protesters. In April 2012, PHR's Richard Sollom, Deputy Director, and Holly Atkinson, MD, FACP, past President of PHR's Board and volunteer expert, authored a report showing the devastation on Bahrain's health system that have resulted from the Government of Bahrain’s continued assault on doctors, patients, and the healthcare system.


A Successful Model Of Road Traffic Injury Surveillance In A Developing Country: Process And Lessons Learnt, Junaid Abdul Razzak, Muhammad Shahzad Shamim, Amber Mehmood, Syed Ameer Hussain, Mir Shabbar Ali, Rashid Jooma 2012 Aga Khan University

A Successful Model Of Road Traffic Injury Surveillance In A Developing Country: Process And Lessons Learnt, Junaid Abdul Razzak, Muhammad Shahzad Shamim, Amber Mehmood, Syed Ameer Hussain, Mir Shabbar Ali, Rashid Jooma

Department of Emergency Medicine

Background: Road Traffic Injuries (RTIs) are one of the leading causes of death and disability worldwide with 90% of global mortality concentrated in the low and middle income countries. RTI surveillance is recommended to define the burden, identify high risk groups, plan intervention and monitor their impact. Despite its stated importance in the literature, very few examples of sustained surveillance systems are reported from low income countries. This paper shares the experience of setting up an urban RTI surveillance program in the emergency departments of five major hospitals in Karachi, Pakistan.
Method: We describe the process of establishing a surveillance …


Ventilator Associated Pneumonia Prevention In The Traumatically Injured Patient: Beyond The Bundle!, Cindy Umbrell MSN,RN,CNS,CCRN, Kenneth Miller MEd, RRT-NPS 2012 Lehigh Valley Health Network

Ventilator Associated Pneumonia Prevention In The Traumatically Injured Patient: Beyond The Bundle!, Cindy Umbrell Msn,Rn,Cns,Ccrn, Kenneth Miller Med, Rrt-Nps

Patient Care Services / Nursing

No abstract provided.


Profiling The Ethnic Characteristics Of Domestic Injuries In Children Younger Than Age 5 Years., Tolulope A. Oyetunji, Adrienne A. Stevenson, Aderonke O. Oyetunji, Sharon K. Onguti, Sarah A. Ames, Adil H. Haider, Benedict C. Nwomeh 2012 Children's Mercy Hospital

Profiling The Ethnic Characteristics Of Domestic Injuries In Children Younger Than Age 5 Years., Tolulope A. Oyetunji, Adrienne A. Stevenson, Aderonke O. Oyetunji, Sharon K. Onguti, Sarah A. Ames, Adil H. Haider, Benedict C. Nwomeh

Manuscripts, Articles, Book Chapters and Other Papers

The home remains a very common location for deadly injuries among children younger than 5 years. The aim of this study is to describe the demographic and injury characteristics of domestic injuries in children younger than 5 years. The National Trauma Data Bank's National Sample Program data set was queried for children younger than 5 years with the injury site classified as home. Bivariate analysis was performed to determine unadjusted differences by ethnicity. Appropriate weight was applied to the sample to determine accurate national estimates. A total of 7,364 children, representing 32,033 children, were analyzed. Overall mortality was 1.6 per …


Childhood Unintentional Injuries: Need For A Community-Based Home Injury Risk Assessments In Pakistan., Adnan A. Hyder, Aruna Chandran, Uzma R. Khan, Nukhba Zia, Cheng-Ming Huang, Sarah Stewart de Ramirez, Junaid Razzak 2012 Johns Hopkins University Bloomberg School of Public Health

Childhood Unintentional Injuries: Need For A Community-Based Home Injury Risk Assessments In Pakistan., Adnan A. Hyder, Aruna Chandran, Uzma R. Khan, Nukhba Zia, Cheng-Ming Huang, Sarah Stewart De Ramirez, Junaid Razzak

Department of Emergency Medicine

Background. A substantial proportion of the annual 875,000 childhood unintentional injury deaths occur in the home. Very few printed tools are available in South Asia for disseminating home injury prevention information. Methods. Three tools were planned: an injury hazard assessment tool appropriate for a developing country setting, an educational pamphlet highlighting strategies for reducing home injury hazards, and an in-home safety tutorial program to be delivered by a trained community health worker. Results. The three tools were successfully developed. Two intervention neighborhoods in Karachi, Pakistan, were mapped. The tools were pretested in this local setting and are now ready for …


Working With Mild Traumatic Brain Injury: Voices From The Field, Page Walker Buck, Rebecca G. Laster, Jocelyn Spencer Sagrati, Rachel Shapiro Kirzner 2012 West Chester University of Pennsylvania

Working With Mild Traumatic Brain Injury: Voices From The Field, Page Walker Buck, Rebecca G. Laster, Jocelyn Spencer Sagrati, Rachel Shapiro Kirzner

Social Work (Graduate) Faculty Publications

No abstract provided.


Challenging Cases In Pediatric Trauma: Management Of The Open Abdomen, Firas Madbak MD, William D. Hardin Jr, MD, FACS, FAAP 2012 Lehigh Valley Health Network

Challenging Cases In Pediatric Trauma: Management Of The Open Abdomen, Firas Madbak Md, William D. Hardin Jr, Md, Facs, Faap

Department of Surgery

No abstract provided.


Association Between Hospitals Caring For A Disproportionately High Percentage Of Minority Trauma Patients And Increased Mortality: A Nationwide Analysis Of 434 Hospitals., Adil H. Haider, Sharon Ong'uti, David T. Efron, Tolulope A. Oyetunji, Marie L. Crandall, Valerie K. Scott, Elliott R. Haut, Eric B. Schneider, Neil R. Powe, Lisa A. Cooper, Edward E. Cornwell 2012 Children's Mercy Hospital

Association Between Hospitals Caring For A Disproportionately High Percentage Of Minority Trauma Patients And Increased Mortality: A Nationwide Analysis Of 434 Hospitals., Adil H. Haider, Sharon Ong'uti, David T. Efron, Tolulope A. Oyetunji, Marie L. Crandall, Valerie K. Scott, Elliott R. Haut, Eric B. Schneider, Neil R. Powe, Lisa A. Cooper, Edward E. Cornwell

Manuscripts, Articles, Book Chapters and Other Papers

OBJECTIVE: To determine whether there is an increased odds of mortality among trauma patients treated at hospitals with higher proportions of minority patients (ie, black and Hispanic patients combined).

DESIGN: Hospitals were categorized on the basis of the percentage of minority patients admitted with trauma. The adjusted odds of in-hospital mortality were compared between hospitals with less than 25% of patients who were minorities (the reference group) and hospitals with 25% to 50% of patients who were minorities and hospitals with more than 50% of patients who were minorities. Multivariate logistic regression (with generalized linear modeling and a cluster-correlated robust …


Research Brief: "Secondary Trauma And Military Veteran Caregivers", Institute for Veterans and Military Families at Syracuse University 2011 Syracuse University

Research Brief: "Secondary Trauma And Military Veteran Caregivers", Institute For Veterans And Military Families At Syracuse University

Institute for Veterans and Military Families

This brief is about the stress that occurs for caregivers of veterans due to secondary trauma. In policy and practice, caregivers can continuously monitor themselves for symptoms of secondary trauma, maintain a balance between professional life and personal life, and promote a supportive culture within the caregiver community; policies should acknowledge that secondary trauma stressors do exist for caregivers and should look for ways to reduce the negative effects of secondary trauma stressors. Suggestions for future research include using econometric models to detect relevant factors for risk of developing secondary trauma stressors.


Variations In Practice Patterns Among Neurosurgeons And Orthopaedic Surgeons In The Management Of Spinal Disorders, Manzar Hussain, Sadaf Nasir, Amber Moed, Ghulam Murtaza 2011 Aga Khan University

Variations In Practice Patterns Among Neurosurgeons And Orthopaedic Surgeons In The Management Of Spinal Disorders, Manzar Hussain, Sadaf Nasir, Amber Moed, Ghulam Murtaza

Section of Neurosurgery

Study design: This is a case series.
Purpose: We wanted to identify variations in the practice patterns among neurosurgeons and orthopedic surgeons for the management of spinal disorders.
Overview of literature: Spinal disorders are common in the clinical practice of both neurosurgeons and orthopedic surgeons. It has been observed that despite the availability of various guidelines, there is lack of consensus among surgeons about the management of various disorders.
Methods: A questionnaire was distributed, either directly or via e-mail, to the both the neurosurgeons and orthopedic surgeons who worked at 5 tertiary care centers within a single region of Korea. …


Endovascular Approach As Primary Treatment For Traumatic Carotid Cavernous Fistula: Local Experience From Pakistan, Rana Shoaib Hamid, Tanveer Ul Haq, Muhammad Shahzad Shamim, Syed Faraz Kazim, Basit Salam 2011 Aga Khan University

Endovascular Approach As Primary Treatment For Traumatic Carotid Cavernous Fistula: Local Experience From Pakistan, Rana Shoaib Hamid, Tanveer Ul Haq, Muhammad Shahzad Shamim, Syed Faraz Kazim, Basit Salam

Department of Radiology

Objective: To evaluate the technical success, complications and outcome of endovascular management of post traumatic carotid cavernous fistula (CCF) in patients presenting at a tertiary care hospital in Karahci.
Methods: Descriptive case series of 26 patients of post traumatic CCF treated by endovascular techniques was carried out at Radiology and Neurosurgery departments of Aga Khan University hospital between January 2010 to March 2010. Medical records and radiology reports were retrospectively reviewed from November 2000 to December 2009. The diagnosis was primarily clinical and was confirmed in all cases by CT or MRI. Endovascular procedures were performed under general anaesthesia through …


Use Of Geocoding And Us Census Data To Assess Determinants Of Outcome In Trauma Patients, Krista M. Goodman MD, John J. Hong MD, Sherrine Eid MPH, Leslie Baga BSN, CCRC, Michael M. Badellino MD, MPH, FACS, Michael D. Pasquale MD, FACS 2011 Lehigh Valley Health Network

Use Of Geocoding And Us Census Data To Assess Determinants Of Outcome In Trauma Patients, Krista M. Goodman Md, John J. Hong Md, Sherrine Eid Mph, Leslie Baga Bsn, Ccrc, Michael M. Badellino Md, Mph, Facs, Michael D. Pasquale Md, Facs

Department of Surgery

No abstract provided.


Diagnostic Accuracy Of Clinical Examination In Cervical Spine Injuries In Awake And Alert Blunt Trauma Patients, Manzar Hussain, Gohar Javed 2011 Aga Khan University

Diagnostic Accuracy Of Clinical Examination In Cervical Spine Injuries In Awake And Alert Blunt Trauma Patients, Manzar Hussain, Gohar Javed

Section of Neurosurgery

Study design: Observational, case series.
Purpose: To determine the sensitivity and specificity of clinical judgment as compared to the use of X-ray images in detecting cervical spine injuries in trauma patients presenting in the emergency department of Aga Khan University Hospital, Karachi.
Overview of literature: Cross-table cervical spine views are important in patients with signs and symptoms relating to cervical spine, but asymptomatic patients constitute a different subgroup. Accuracy of clinical examination in these patients has not been subjected to scrutiny.
Methods: All patients with blunt trauma who presented to the emergency department and underwent cross-table X-rays as part of …


A Warm Welcome Goes A Long Way., Jody Shigo RN, CMSRN, Eileen Fruchtl MSN, RN, CCRN, CMSRN, Kai Bortz BSN, RN, CMSRN 2011 Lehigh Valley Health Network

A Warm Welcome Goes A Long Way., Jody Shigo Rn, Cmsrn, Eileen Fruchtl Msn, Rn, Ccrn, Cmsrn, Kai Bortz Bsn, Rn, Cmsrn

Patient Care Services / Nursing

No abstract provided.


Clue: A Randomized Comparative Effectiveness Trial Of Iv Nicardipine Versus Labetalol Use In The Emergency Department, W Peacock, Joseph Varon, Brigitte M. Baumann, Pierre Borczuk, Chad M. Cannon, Abhinav Chandra, David M. Cline, Deborah Diercks, Brian Hiestand, A Hsu, Preeti Jois-Bilowich, Brian Kaminski, Philip Levy, Richard M. Nowak, Jon W. Schrock 2011 The Cleveland Clinic

Clue: A Randomized Comparative Effectiveness Trial Of Iv Nicardipine Versus Labetalol Use In The Emergency Department, W Peacock, Joseph Varon, Brigitte M. Baumann, Pierre Borczuk, Chad M. Cannon, Abhinav Chandra, David M. Cline, Deborah Diercks, Brian Hiestand, A Hsu, Preeti Jois-Bilowich, Brian Kaminski, Philip Levy, Richard M. Nowak, Jon W. Schrock

Wayne State University Associated BioMed Central Scholarship

Abstract

Introduction

Our purpose was to compare the safety and efficacy of food and drug administration (FDA) recommended dosing of IV nicardipine versus IV labetalol for the management of acute hypertension.

Methods

Multicenter randomized clinical trial. Eligible patients had 2 systolic blood pressure (SBP) measures ≥180 mmHg and no contraindications to nicardipine or labetalol. Before randomization, the physician specified a target SBP ± 20 mmHg (the target range: TR). The primary endpoint was the percent of subjects meeting TR during the initial 30 minutes of treatment.

Results

Of 226 randomized patients, 110 received nicardipine and 116 labetalol. End organ damage …


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