Radiation Medicine Commons^™

A Contemporary Dose Selection Algorithm For Stereotactic Radiosurgery In The Treatment Of Brain Metastases - An Initial Report., R. J. Colaco, J. B. Yu, J. S. Bond, R. S. Bindra, J. N. Contessa, J. P. S. Knisely, V. L. Chiang

Journal Articles

Indications and treatment goals for SRS have changed since the publication of RTOG 90-05. We present initial retrospective outcomes from a new dose selection algorithm in use at our institution felt to be more contemporary with doses being used in the radiosurgery community today and report our local control and toxicity outcomes. This dose selection algorithm will be subject to a forthcoming prospective phase 2 trial.To evaluate safety and efficacy of an institutional dose selection algorithm in the treatment of brain metastases (BM) with single fraction radio-surgery (SRS).The medical records of 65 patients with ≤10 BM treated with GK at …

Defining The Value Framework For Prostate Brachytherapy Using Patient-Centered Outcome Metrics And Time-Driven Activity-Based Costing, N. G. Thaker, T. J. Pugh, U. Mahmood, S. Choi, T. E. Spinks, N. E. Martin, T. T. Sio, B. W. Cox, L. Potters, S. J. Frank, +8 Additional Authors

Journal Articles

No abstract provided.

Effect Of The Normalized Prescription Isodose Line On The Magnitude Of Monte Carlo Vs. Pencil Beam Target Dose Differences For Lung Stereotactic Body Radiotherapy, D. Zheng, Q. Zhang, X. Liang, X. Zhu, V. Verma, S. Wang, S. Zhou

Journal Articles

© This work is licensed under a Creative Commons Attribution 3.0 Unported License. In lung stereotactic body radiotherapy (SBRT) cases, the pencil beam (PB) dose calculation algorithm is known to overestimate target dose as compared to the more accurate Monte Carlo (MC) algorithm. We investigated whether changing the normalized prescription isodose line affected the magnitude of MC vs. PB target dose differences. Forty-eight patient plans and twenty virtual-tumor phantom plans were studied. For patient plans, four alternative plans prescribed to 60%, 70%, 80%, and 90% isodose lines were each created for 12 patients who previously received lung SBRT treatments. Using …

Target Dose Conversion Modeling From Pencil Beam (Pb) To Monte Carlo (Mc) For Lung Sbrt, D. Zheng, X. Zhu, Q. Zhang, X. Liang, W. Zhen, C. Lin, V. Verma, S. Wang, A. Wahl, C. Zhang, +2 Additional Authors

Journal Articles

© 2016 The Author(s). Background: A challenge preventing routine clinical implementation of Monte Carlo (MC)-based lung SBRT is the difficulty of reinterpreting historical outcome data calculated with inaccurate dose algorithms, because the target dose was found to decrease to varying degrees when recalculated with MC. The large variability was previously found to be affected by factors such as tumour size, location, and lung density, usually through sub-group comparisons. We hereby conducted a pilot study to systematically and quantitatively analyze these patient factors and explore accurate target dose conversion models, so that large-scale historical outcome data can be correlated with more …

Predicting Treatment Related Imaging Changes (Trics) After Radiosurgery For Brain Metastases Using Treatment Dose And Conformality Metrics., B. F. Taylor, J. P. Knisely, J. M. Qian, J. B. Yu, V. L. Chiang

Journal Articles

Purpose: Treatment-related imaging changes (TRICs) after stereotactic radiosurgery (SRS) involves the benign transient enlargement of radiographic lesions after treatment. Identifying the radiation dose volumes and conformality metrics associated with TRICs for different post-treatment periods would be helpful and improve clinical decision making.

Methods: 367 metastases in 113 patients were treated using Gamma Knife SRS between 1/1/2007-12/31/2009. Each metastasis was measured at each imaging follow-up to detect TRICs (defined as ≥ 20% increase in volume). Fluctuations in small volume lesions (less than 108 mm

Results: From 0-6 months, all measures correlated with the incidence of TRICs (p

Conclusions: All metrics except …

Cytoplasmic, Full Length And Novel Cleaved Variant, Tblr1 Reduces Apoptosis In Prostate Cancer Under Androgen Deprivation, G. Daniels, X. Zhang, X. Zhong, L. Santiago, L. H. Wang, X. Wu, J. Y. Zhang, F. Liang, X. Li, P. Lee, +6 Additional Authors

Journal Articles

No abstract provided.

The Utilization Of The Anatomage Virtual Dissection Table In The Education Of Imaging Science Students, Tanya M. Custer, Kim Michael

Posters and Presentations: Medical Imaging & Therapeutic Sciences

Objectives: The purpose of this research was to investigate the use of the Anatomage Virtual Dissection Table in the education of imaging science students and to assess the beliefs and perceptions of the students in regard to using the Table for teaching imaging-based anatomy & pathology.

Subjects & Methods: Study participants included 17 medical imaging students to include 9 Diagnostic Medical Sonography students, 2 Magnetic Resonance Imaging students, 2 Nuclear Medicine Technology students, 2 Radiation Therapy students and 2 Cardiovascular Interventional Technology students. Data was collected through focus groups and course/instructor evaluations. The researchers followed Creswell’s procedure for data analysis …

Weighing The Risks And Benefits Of Radiation Exposure And Diagnostic X-Rays In Children, Leah Costello

Physician Assistant Scholarly Project Posters

The number of X-rays, specifically CT scans, performed on patients in the United States is increasing exponentially every year. Children are at most risk for long term damage from this increase in radiation exposure. This study explores how much risk children are being exposed to and how we can, as practitioners, make informed decisions about when or when not to order CT scans. The purpose of this paper is to provide practitioners the information needed to help patients decide if the long-term risks of cancer from medical radiation outweigh the potential benefit of diagnostic or therapeutic radiation. The review of …

Effect Of Variable Dose Rate On Biologically Effective Dose, Vadim Y. Kuperman, Gregory S. Spradlin

Publications

Purpose: to investigate the effect of variable dose rate on biologically effective dose ( BED ).

Materials and methods: by using the linear-quadratic (LQ) model with bi-exponential repair, we analytically determine the time-dependent dose rate R ~ which minimizes the effective protraction factor ( eff G ) and BEDunder the condition of fixed fraction time and dose per fraction.  Because normal tissue complication probability ( NTCP) monotonically decreases with decreasingBED , the dose rate R ~ also minimizes NTCP.

Results: the dependences of Geff, BED, and NTCP on fraction time were determined for different radiobiological parameters and two different …

Cisplatin-Induced Posterior Reversible Encephalopathy Syndrome And Successful Re-Treatment In A Patient With Non-Seminomatous Germ Cell Tumor: A Case Report, Muhammad Nauman Zahir, Nehal Masood, Munira Shabbir-Moosajee

Department of Radiation Oncology

UNLABELLED: Introduction: Cisplatin is a platinum compound that has revolutionized the treatment of various solid organ tumors. Cisplatin is associated with a variety of side effects and has recently been indicted in the development of posterior reversible encephalopathy syndrome. Posterior reversible encephalopathy syndrome is a potentially reversible condition, with the mainstay of therapy being correction of the underlying cause and withdrawal of the offending drug. However, there are no clear guidelines regarding the possibility of subsequent re-treatment with the causative agent.CASE PRESENTATION: A 23-year-old Asian man presented to our Emergency Department with a four-month history of concomitant abdominal pain and …

The Relationship Between The Level Of Support Group Participation And Psychosocial Factors In Prostate Cancer Patients Treated With Proton Therapy, Carol A. L. Davis

Loma Linda University Electronic Theses, Dissertations & Projects

Background. The role of support groups for cancer patients is known to be beneficial in helping people adjust to the disease, and cope with the myriad of effects that cancer has on quality of life. Although many people express interest in attending such support groups, few attend regularly. It is unclear what characteristics distinguish those who use such services from those who do not, especially among proton therapy patients.

Objective. To examine demographic and psychosocial characteristics associated with the Brotherhood of the Balloon (BOB) prostate cancer support group membership, a unique treatment-focused group originating at Loma Linda University Medical Center …