Optic Neuritis Due To Toxoplasmosis: First And Only Manifestation Of Newly Diagnosed Aids,
2013
Lehigh Valley Health Network
Optic Neuritis Due To Toxoplasmosis: First And Only Manifestation Of Newly Diagnosed Aids, Rajesh Kumar Md, Yehia Y. Mishriki Md
Department of Medicine
No abstract provided.
Austrian Syndrome: Triad Of The Past Or Harbinger Of The Future?,
2013
Lehigh Valley Health Network
Austrian Syndrome: Triad Of The Past Or Harbinger Of The Future?, Mira Mitry Md, Suzanne J. Templer Do, Stacey Smith Md, Facp, Eugene P. York Md, Facp
Department of Medicine
No abstract provided.
Necrostatin-1 Analogues: Critical Issues On The Specificity, Activity And In Vivo Use In Experimental Disease Models.,
2012
Department for Molecular Biomedical Research, VIB, Ghent University; Department of Biomedical Molecular Biology, Ghent University
Necrostatin-1 Analogues: Critical Issues On The Specificity, Activity And In Vivo Use In Experimental Disease Models., N Takahashi, L Duprez, S Grootjans, A Cauwels, W Nerinckx, J B Duhadaway, V Goossens, R Roelandt, F Van Hauwermeiren, C Libert, W Declercq, N Callewaert, G C Prendergast, A Degterev, J Yuan, P Vandenabeele
Department of Pathology, Anatomy, and Cell Biology Faculty Papers
Necrostatin-1 (Nec-1) is widely used in disease models to examine the contribution of receptor-interacting protein kinase (RIPK) 1 in cell death and inflammation. We studied three Nec-1 analogs: Nec-1, the active inhibitor of RIPK1, Nec-1 inactive (Nec-1i), its inactive variant, and Nec-1 stable (Nec-1s), its more stable variant. We report that Nec-1 is identical to methyl-thiohydantoin-tryptophan, an inhibitor of the potent immunomodulatory enzyme indoleamine 2,3-dioxygenase (IDO). Both Nec-1 and Nec-1i inhibited human IDO, but Nec-1s did not, as predicted by molecular modeling. Therefore, Nec-1s is a more specific RIPK1 inhibitor lacking the IDO-targeting effect. Next, although Nec-1i was ∼100 × …
Quantifying The Cdk Inhibitor Vmy-1-103'S Activity And Tissue Levels In An In Vivo Tumor Model By Lc-Ms/Ms And By Mri.,
2012
Lombardi Comprehensive Cancer Center, Department of Oncology, Georgetown University Medical Center
Quantifying The Cdk Inhibitor Vmy-1-103'S Activity And Tissue Levels In An In Vivo Tumor Model By Lc-Ms/Ms And By Mri., Paul Sirajuddin, Sudeep Das, Lymor Ringer, Olga C Rodriguez, Angiela Sivakumar, Yi-Chien Lee, Aykut Üren, Stanley T Fricke, Brian Rood, Alpay Ozcan, Sean S Wang, Sana Karam, Venkata Yenugonda, Patricia Salinas, Emanuel Petricoin, Michael Pishvaian, Michael P Lisanti, Yue Wang, Richard Schlegel, Bahram Moasser, Chris Albanese
Kimmel Cancer Center Faculty Papers
The development of new small molecule-based therapeutic drugs requires accurate quantification of drug bioavailability, biological activity and treatment efficacy. Rapidly measuring these endpoints is often hampered by the lack of efficient assay platforms with high sensitivity and specificity. Using an in vivo model system, we report a simple and sensitive liquid chromatography-tandem mass spectrometry assay to quantify the bioavailability of a recently developed novel cyclin-dependent kinase inhibitor VMY-1-103, a purvalanol B-based analog whose biological activity is enhanced via dansylation. We developed a rapid organic phase extraction technique and validated wide and functional VMY-1-103 distribution in various mouse tissues, consistent with …
Enhancing Resident Education By Empowering The Learner Through The Creation Of Smartphone Applications,
2012
Lehigh Valley Health Network
Enhancing Resident Education By Empowering The Learner Through The Creation Of Smartphone Applications, Christine W. Du Md, Dale A. Dangleben Md, Judith A. Olenwine Ms, C-Tagme, Michael M. Badellino Md
Department of Surgery
No abstract provided.
Invisible Chronic Illness: Invisible Is Not Imaginary,
2012
Eastern Illinois University
Invisible Chronic Illness: Invisible Is Not Imaginary, Rebecca L. Tadlock-Marlo
Faculty Research & Creative Activity
The need for counselors to be versed in various areas of multicultural counseling is a requirement to the profession (ACA Code of Ethics, 2005). Providing a basis of counselor knowledge in dealing with the various areas of multiculturalism is necessary to revolutionize how we are able to help clients with various life stories. One of the goals within the ACA standards is to help navigate a sense of empowerment for such clients. Counselors must promote holistic wellness in the often challenging social, emotional, cognitive, and spiritual path of comeback. With the rise in invisible chronic physical conditions, the importance of …
Delayed Diagnosis Of Hand Injuries In Polytrauma Patients (Poster),
2012
Lehigh Valley Health Network
Delayed Diagnosis Of Hand Injuries In Polytrauma Patients (Poster), Joshua M. Adkinson Md, Muhammad Shuja Shafqat Md, Sherrine Eid Mph, Marshall G. Miles Do
Department of Surgery
No abstract provided.
Conventional Isolated Aortic Valve Replacement In Octogenarians: A 10-Year Single Center Experience,
2012
Lehigh Valley Health Network
Conventional Isolated Aortic Valve Replacement In Octogenarians: A 10-Year Single Center Experience, James K. Wu Md, Justin D. Roberts Do, Gregory S. Troutman Bs, Michael J. Weiss Mph, Sanjay M. Mehta Md, Theodore G. Phillips Md, Michael F. Szwerc Md, Gary W. Szydlowski Md, Timothy S. Misselbeck, Raymond L. Singer Md
Department of Surgery
No abstract provided.
Life History Theory And Social Psychology.,
2012
University of Southern Mississippi
Life History Theory And Social Psychology., Donald F Sacco, Karol Osipowicz
Department of Neurology Faculty Papers
No abstract provided.
Biosynthetic Pathways And The Role Of The Mas Receptor In The Effects Of Angiotensin-(1-7) In Smooth Muscles.,
2012
Department of Medicine, Jefferson Medical College, Thomas Jefferson University
Biosynthetic Pathways And The Role Of The Mas Receptor In The Effects Of Angiotensin-(1-7) In Smooth Muscles., Marcio Augusto Fressatto De Godoy, Larissa Pernomian, Ana Maria De Oliveira, Satish Rattan
Department of Medicine Faculty Papers
Ang-(1-7) is produced via degradation of Ang II by the human angiotensin converting enzyme, also known as ACE2. In the cardiovascular system, Ang-(1-7) has been shown to produce effects that are opposite to those of Ang II. These include smooth muscle relaxation and cardioprotection. While the roles of Ang-(1-7) in other systems are currently topic of intense research, functional data suggest a relaxation action in gastrointestinal smooth muscles in a way that corroborates the results obtained from vascular tissues. However, more studies are necessary to determine a relevant role for Ang-(1-7) in the gastrointestinal system. The Ang-(1-7) actions are mediated …
The Effect Of Pre-Operative Coumadin Therapy On Patients Who Develop Hemorrhagic Events Post Bariatric Surgery,
2012
Lehigh Valley Health Network
The Effect Of Pre-Operative Coumadin Therapy On Patients Who Develop Hemorrhagic Events Post Bariatric Surgery, Richard Boorse Md, Peter J. Bechtel Md, Cathleen Webber Rn, Mshs, Suzanne L. Smith Mba, Rrt, Tas, Cathy Fuhrman Rn, Msn
Department of Surgery
No abstract provided.
Management Of Hyperglycemia In Type 2 Diabetes: A Patient-Centered Approach: Position Statement Of The American Diabetes Association (Ada) And The European Association For The Study Of Diabetes (Easd).,
2012
Section of Endocrinology, Yale University School of Medicine and Yale-New Haven Hospital
Management Of Hyperglycemia In Type 2 Diabetes: A Patient-Centered Approach: Position Statement Of The American Diabetes Association (Ada) And The European Association For The Study Of Diabetes (Easd)., Silvio E Inzucchi, Richard M Bergenstal, John B Buse, Michaela Diamant, Ele Ferrannini, Michael Nauck, Anne L Peters, Apostolos Tsapas, Richard Wender, David R. Matthews
Department of Family & Community Medicine Faculty Papers
No abstract provided.
Perspectives On: Sgp Symposium On Mitochondrial Physiology And Medicine: Mitochondria Take Center Stage.,
2012
Department of Medicine, Center for Translational Medicine, Jefferson Medical College, Thomas Jefferson University
Perspectives On: Sgp Symposium On Mitochondrial Physiology And Medicine: Mitochondria Take Center Stage., Shey-Shing Sheu, Robert T Dirksen, Edward N Pugh
Center for Translational Medicine Faculty Papers
No abstract provided.
Daily Experiences Of Older Adults With Mild Cognitive Impairment,
2012
University of South Florida
Daily Experiences Of Older Adults With Mild Cognitive Impairment, Elizabeth Hahn
USF Tampa Graduate Theses and Dissertations
Rationale and study aims: Persons with mild cognitive impairment (MCI) experience declines in everyday functioning and cognitive performance greater than what is experienced in normal aging but less than that of dementia. Daily stress and daily memory complaints associated with cognitive deficits may contribute to greater psychological distress in the day-to-day experiences of persons with MCI. However, research examining the occurrence of daily stressors, daily memory complaints and psychological distress in MCI is limited, and it is not clear how the daily processes of stress and affect in persons with MCI compare to cognitively healthy older adults. This dissertation examined …
Road Map To Becoming A Physician Assistant,
2012
University of Rhode Island
Road Map To Becoming A Physician Assistant, Maguire J. Miller
Senior Honors Projects
The field of medicine is under constant change and reconstruction, especially when it comes to healthcare practitioners. When a demand is placed on the system, healthcare providers must figure out how they can satisfy the medical needs of the population. Within the past few decades there has been a shortage of people who are capable of fulfilling these needs. For this reason a new profession has been developed; it is called a Physician Assistant (PA). Professionals with this title have been through a rigorous training modeled after what a medical student goes through, but it is condensed into a much …
Mitochondrial Lysyl-Trna Synthetase Independent Import Of Trna Lysine Into Yeast Mitochondria.,
2012
Department of Biochemistry, School of Life Sciences, University of Hyderabad; Department of Biochemistry and Molecular Pharmacology, Thomas Jefferson University
Mitochondrial Lysyl-Trna Synthetase Independent Import Of Trna Lysine Into Yeast Mitochondria., Naresh Babu V Sepuri, Madhavi Gorla, Michael P King
Department of Biochemistry and Molecular Biology Faculty Papers
Aminoacyl tRNA synthetases play a central role in protein synthesis by charging tRNAs with amino acids. Yeast mitochondrial lysyl tRNA synthetase (Msk1), in addition to the aminoacylation of mitochondrial tRNA, also functions as a chaperone to facilitate the import of cytosolic lysyl tRNA. In this report, we show that human mitochondrial Kars (lysyl tRNA synthetase) can complement the growth defect associated with the loss of yeast Msk1 and can additionally facilitate the in vitro import of tRNA into mitochondria. Surprisingly, the import of lysyl tRNA can occur independent of Msk1 in vivo. This suggests that an alternative mechanism is present …
Dyschronic, A Drosophila Homolog Of A Deaf-Blindness Gene, Regulates Circadian Output And Slowpoke Channels.,
2012
Farber Institute for Neurosciences, Thomas Jefferson University
Dyschronic, A Drosophila Homolog Of A Deaf-Blindness Gene, Regulates Circadian Output And Slowpoke Channels., James E C Jepson, Mohammad Shahidullah, Angelique Lamaze, Drew Peterson, Huihui Pan, Kyunghee Koh
Farber Institute for Neuroscience Faculty Papers
Many aspects of behavior and physiology are under circadian control. In Drosophila, the molecular clock that regulates rhythmic patterns of behavior has been extensively characterized. In contrast, genetic loci involved in linking the clock to alterations in motor activity have remained elusive. In a forward-genetic screen, we uncovered a new component of the circadian output pathway, which we have termed dyschronic (dysc). dysc mutants exhibit arrhythmic locomotor behavior, yet their eclosion rhythms are normal and clock protein cycling remains intact. Intriguingly, dysc is the closest Drosophila homolog of whirlin, a gene linked to type II Usher syndrome, the leading cause …
Gender-Sensitive Reporting In Medical Research.,
2012
International AIDS Society, Geneva, Switzerland
Gender-Sensitive Reporting In Medical Research., Shirin Heidari, Quarraisha Abdool Karim, Judith D Auerbach, Simone E Buitendijk, Pedro Cahn, Mirjam J Curno, Catherine Hankins, Elly Katabira, Susan Kippax, Richard Marlink, Joan Marsh, Ana Marusic, Heidi M Nass, Julio Montaner, Elizabeth Pollitzer, Maria Teresa Ruiz-Cantero, Lorraine Sherr, Papa Salif Sow, Kathleen Squires, Mark A Wainberg
Department of Medicine Faculty Papers
Sex and gender differences influence the health and wellbeing of men and women. Although studies have drawn attention to observed differences between women and men across diseases, remarkably little research has been pursued to systematically investigate these underlying sex differences. Women continue to be underrepresented in clinical trials, and even in studies in which both men and women participate, systematic analysis of data to identify potential sex-based differences is lacking. Standards for reporting of clinical trials have been established to ensure provision of complete, transparent and critical information. An important step in addressing the gender imbalance would be inclusion of …
Loss Of Αt-Catenin Alters The Hybrid Adhering Junctions In The Heart And Leads To Dilated Cardiomyopathy And Ventricular Arrhythmia Following Acute Ischemia.,
2012
Center for Translational Medicine, Department of Medicine, Thomas Jefferson University
Loss Of Αt-Catenin Alters The Hybrid Adhering Junctions In The Heart And Leads To Dilated Cardiomyopathy And Ventricular Arrhythmia Following Acute Ischemia., Jifen Li, Steven Goossens, Jolanda Van Hengel, Erhe Gao, Lan Cheng, Koen Tyberghein, Xiying Shang, Riet De Rycke, Frans Van Roy, Glenn L Radice
Center for Translational Medicine Faculty Papers
It is generally accepted that the intercalated disc (ICD) required for mechano-electrical coupling in the heart consists of three distinct junctional complexes: adherens junctions, desmosomes and gap junctions. However, recent morphological and molecular data indicate a mixing of adherens junctional and desmosomal components, resulting in a 'hybrid adhering junction' or 'area composita'. The α-catenin family member αT-catenin, part of the N-cadherin-catenin adhesion complex in the heart, is the only α-catenin that interacts with the desmosomal protein plakophilin-2 (PKP2). Thus, it has been postulated that αT-catenin might serve as a molecular integrator of the two adhesion complexes in the area composita. …
The Influence Of Antiretroviral Therapy On The Qtc Interval In An African Cohort,
2012
Aga Khan University
The Influence Of Antiretroviral Therapy On The Qtc Interval In An African Cohort, J. Shavadia, Reena Shah, Gerald Yonga, R. Patel, J. Stebbing, M. Nelson
Internal Medicine, East Africa
Cardiovascular disease in human immunodeficiency virus (HIV) infection encompasses a wide range of pathologic entities, including myocardial, pericardial, and endocardial disease, atherosclerosis, arrhythmias, and vasculitis. The most common manifestations of HIV-associated heart disease in sub- Saharan Africa are pericarditis, cardiomyopathy, and pulmonary hypertension [1]. Coronary artery disease, lipodystrophy, and metabolic syndrome, although common in developed countries, are traditionally thought to be less clinically significant problems in the African subcontinent [2]. It is well known that prolongation of the QTC interval can predispose patients to potentially fatal ventricular tachyarrhythmias, particularly torsades de pointes, and thus is an independent predictor of cardiovascular …
