Ophthalmology Commons^™

The Relationship Between Spectral Signals And Retinal Sensitivity In Dendrobatid Frogs, Whitney G. Walkowski, Corinne L. Richards-Zawacki, William C. Gordon, Nicolas G. Bazan, Hamilton E. Farris

School of Graduate Studies Faculty Publications

Research on visually driven behavior in anurans has often focused on Dendrobatoidea, a clade with extensive variation in skin reflectance, which is perceived to range from cryptic to conspicuous coloration. Because these skin patterns are important in intraspecific and interspecific communication, we hypothesized that the visual spectral sensitivity of dendrobatids should vary with conspecific skin spectrum. We predicted that the physiological response of frog retinas would be tuned to portions of the visible light spectrum that match their body reflectance. Using wavelength-specific electroretinograms (ERGs; from 350-650 nm), spectrometer measurements, and color-calibrated photography of the skin, we compared retinal sensitivity and …

Gender Representation Of Presenters At American Academy Of Ophthalmology Conferences From 2004-2019, Eleanor Burton, Chase Paulson, Ayesha Patil, Ruby Garcia, Sydni Johnson, Josie White, Adriana Rush, Devin Eddington, Jeff H. Pettey, Rachel G. Simpson

Journal of Academic Ophthalmology

Importance: Gender equity is an important topic in medicine and accurate trends are essential to evaluate historical, current, and future trends.

Objective: To describe changes in gender representation at American Academy of Ophthalmology (AAO) meetings from 2004 to 2019.

Participants: Presenters at the American Academy of Ophthalmology meetings from 2004 to 2019.

Design & Setting: This is a retrospective cross-sectional study. Data was extracted using AAO annual and subspecialty meeting archives for every third year between 2004 and 2019. Sessions were stratified by category and subspecialty. Poster sessions were excluded. Gender was considered binary and determined …

Representation Of Women At Select Academic Ophthalmology Institutions In The United States, Hazem M Mousa, Camryn Thompson, Sri Meghana Konda, Keke Liu, Jay Rathinavelu, Terry Lee, Katherine Peters, Kevin J. Jackson, Laura Enyedi, Pratap Challa, Sharon Fekrat

Journal of Academic Ophthalmology

Purpose: To investigate the representation of women among ophthalmology faculty members at select academic institutions in the United States (US).

Design: Cross-sectional study

Subjects: Clinical faculty members at the top 20 academic ophthalmology institutions in the U.S. according to US News and World Report ranking

Methods: Gender as reported on institutional websites either directly or via pronouns, academic rank, medical school graduation year, and subspecialty were collected about clinical faculty members with MD, MD/PhD, MBBS or DO from their respective institutional websites. The number of publications for each faculty member was collected using Scopus ® (Elsevier, …

Cataract Simulator Training And Medical Student Attitudes Towards Ophthalmology, Victor Sanchez, Christian Diaz, Zachary Elkin, Laura Palazzolo, Andrea Blitzer, Manjool Shah, Christina R. Prescott

Journal of Academic Ophthalmology

Introduction: Simulation-based learning offers novel opportunities to teach ophthalmology to medical students and inspire interest in the field. Eyesi surgical simulators have become widely adopted by ophthalmology departments and may serve a purpose in medical student education. The purpose of this study was to evaluate the effect of cataract simulators on medical student attitudes towards ophthalmology and to assess their performance/improvement on a series of simulator tasks.

Methods: This was a prospective, cross-sectional study of 31 medical students. Participants were recruited through an email sent via the school’s listserv. Enrolled students completed a series of tasks on the …

Real-World Assessment (Rwa): Validity Evidence For Cataract Surgery With A Tool Your Faculty Will Actually Use, Grace L. Paley, Hui Zhao, Victoria M. Addis, Casey J. Beal, Geetha K. Davis, Gabriela M. Espinoza, Michael S. Lee, Stacy L. Pineles, Jamie B. Rosenberg, Robert T. Swan, Misha F. Syed, Evan L. Waxman, Susan M. Culican

Journal of Academic Ophthalmology

Background: We developed and implemented a real-world assessment tool (RWA) for resident surgery. It was designed to improve utility by reducing faculty and trainee cost (completion and training time, cognitive burden). RWA uses an entrustability scale where higher scores indicate a resident’s readiness for independent surgical practice. We describe a two-phase implementation of RWA and report validity evidence for cataract surgery assessment.

Methods: RWA was developed iteratively with resident and faculty input and piloted at a single residency program in phase 1. Phase 2 implemented RWA at 11 ophthalmology residency programs. The main outcome measures were 1) number …

Student Perceptions Of A Novel No-Cost Mobile Application For Ophthalmic History And Physical Examination, Soryan Kumar, Anagha Lokhande, Spandana Jarmale, Arnav Kumar, Samantha Rosenthal, Grayson W. Armstrong, Michael Migliori, Jamie Schaefer

Journal of Academic Ophthalmology

Background: Mobile applications have shown promise in enhancing medical trainee performance. In ophthalmology, a comprehensive mobile app can streamline the trainee education process by providing guidance for patient intake. Language barriers pose additional challenges impacting the quality of care for Spanish-speaking patients; literature has documented the adverse impacts of inadequate translation on quality of medical care for both trainees and patients. We aim to develop a free mobile application to guide medical trainees through the ophthalmic patient intake process and assist with Spanish-language translation.

Methods: We developed EyeCheck as a free mobile application for ophthalmology trainee education with …

Community Outreach Vision Screenings With Student-Led Eye Health Education Improves Student Eye Health Knowledge And Ophthalmic Health Disparities Awareness, Tannia M. Rodriguez, Karim Dirani, Samantha M. Arsenault, Ryan Lee Freedman, John-Michael Guest, Kathleen George, Collin Richards, Leo Hall, Mark S. Juzych, Anju Goyal

Journal of Academic Ophthalmology

BACKGROUND: The high prevalence of vision impairment and discordant lack of eye care utilization makes it essential to develop effective avenues to educate the future physician work force regarding basic eye health knowledge and ophthalmic health disparities. The public is often not aware that blinding eye diseases can begin asymptomatically. It is important for medical students to understand basic eye health knowledge, such as blinding eye diseases can begin asymptomatically. The purpose of this study was to assess the impact of an eye health knowledge 5-Point Teaching Intervention (5PTI) and structured patient intake form on student eye health knowledge and …

Total Retinal Thickness Is An Important Factor In Evaluating Diabetic Retinal Neurodegeneration, Noor-Us-Sabah Ahmad, Kristen Staggers, Kyungmoo Lee, Nitish Mehta, Amitha Domalpally, Benjamin J Frankfort, Yao Liu, Roomasa Channa

Faculty, Staff and Students Publications

OBJECTIVE: Macular retinal nerve fibre layer (mRNFL) and ganglion cell-inner plexiform layer thickness (GC-IPL) measurements are important markers of diabetic retinal neurodegeneration (DRN). In this cross-sectional study, we aimed to quantify the contribution of total retinal thickness (TRT) and other factors in the variation of mRNFL and GC-IPL thickness among participants with diabetes.

METHODS AND ANALYSIS: We used macular-centred spectral domain-optical coherence tomography scans from participants with diabetes in the UK Biobank. Two multiple linear regression models (prior to and after adjusting for TRT) were used to determine factors associated with mRNFL and GC-IPL thicknesses. A p value of less …

Transport Of Β-Amyloid From Brain To Eye Causes Retinal Degeneration In Alzheimer’S Disease, Qiuchen Cao, Shige Yang, Xiaowei Wang, Huaiqing Sun, Weijie Chen, Yuliang Wang, Junying Gao, Yanchi Wu, Qiuhua Yang, Xue Chen, Songtao Yuan, Ming Xiao, Maiken Nedergaard, Yuqing Huo, Qinghuai Liu

Faculty, Staff and Students Publications

The eye is closely connected to the brain, providing a unique window to detect pathological changes in the brain. In this study, we discovered β-amyloid (Aβ) deposits along the ocular glymphatic system in patients with Alzheimer's disease (AD) and 5×FAD transgenic mouse model. Interestingly, Aβ from the brain can flow into the eyes along the optic nerve through cerebrospinal fluid (CSF), causing retinal degeneration. Aβ is mainly observed in the optic nerve sheath, the neural axon, and the perivascular space, which might represent the critical steps of the Aβ transportation from the brain to the eyes. Aquaporin-4 facilitates the influx …

A 32-Year-Old Male With Corneal Hydrops, Justin Anderson, Ryan Grinnell, Kristina Domanski, Jamie Baydoun

School of Medicine Faculty Research

A 32-year-old male with a history of left eye keratoconus presented to the emergency department with left eye pain and blurry vision for two days. Out of concern for corneal hydrops, ophthalmology was consulted, and the diagnosis was confirmed. Per ophthalmology recommendations, the patient was started on hypertonic saline and prednisolone eye drops and referred to a corneal specialist.

Systemic Effects Of Anti-Vegf Intravitreal Injection In Patients With Age-Related Macular Degeneration: A Multi-Institutional Real-World Study, Tzu-Yi Lin, Yi-Ting Hsieh, Sunir J. Garg, Lee-Jen Chen, Kuan-Jen Chen, Wei-Chi Wu, Chi-Chun Lai, Yih-Shiou Hwang, Eugene Yu-Chuan Kang

Wills Eye Hospital Papers

PURPOSE: In individuals aged >50 years, age-related macular degeneration (AMD) is the leading cause of irreversible blindness. Intravitreal injections of antivascular endothelial growth factor (VEGF) agents (bevacizumab, ranibizumab, and aflibercept) show good efficacy and similar incidences of systemic adverse events (SAEs). However, comparative studies between agents are limited. Our study aimed to compare the real-world SAE risks of bevacizumab, ranibizumab, and aflibercept users.

METHODS: This retrospective cohort study identified new bevacizumab, ranibizumab, and aflibercept users in a multi-institutional database in Taiwan between 2014 and 2019. Inverse probability of treatment weights (IPTW) with propensity scores was conducted to achieve homogeneity among …

A Unilateral Myopic Shift Secondary To Sturge-Weber Syndrome Results In Refractive Amblyopia Of The Fellow Eye In A Pediatric Patient, Mckenzie Stewart, Christina Twardowski

Posters

A 4-year-old patient with unilateral glaucoma secondary to Sturge-Weber Syndrome causes a myopic shift. The fellow healthy eye maintains high hyperopia resulting in anisometropic refractive amblyopia, requiring occlusion therapy. It is well documented that a glaucomatous high IOP causes an expansion of the globe due to excessive plasticity of collagen fibers in pediatric eyes. The elongated axial length induces myopic shifts. In this patient, the myopic shift in her glaucomatous eye resulted in a unilateral high hyperopic refractive error in the fellow eye with normal ocular health. This anisometropia is enough to cause amblyopia in the hyperopic eye. In past …

Suppression Of Matrigel-Induced Choroidal Neovascularization By Aav Delivery Of A Novel Anti-Scg3 Antibody, Chengchi Huang, Avinash Kaur, Liyang Ji, Hong Tian, Keith A Webster, Wei Li

Faculty, Staff and Students Publications

Efforts to develop gene therapy for long-term treatment of neovascular disease are hampered by ongoing concerns that biologics against vascular endothelial growth factor (VEGF) inhibit both physiological and pathological angiogenesis and are therefore at elevated risk of adverse side effects. A potential solution is to develop disease-targeted gene therapy. Secretogranin III (Scg3), a unique disease-restricted angiogenic factor described by our group, contributes significantly to ocular neovascular disease. We have shown that Scg3 blockade with a monoclonal antibody Fab fragment (Fab) stringently inhibits pathological angiogenesis without affecting healthy vessels. Here we tested the therapeutic efficacy of adeno-associated virus (AAV)-anti-Scg3Fab to block …

Eyelid Reconstruction, Srinithya R Gillipelli, Diego M Quirarte, Winston R Owens, Matthew J Parham, Austin Y Jiang, Katherine J Williams, Amy S Xue

Faculty, Staff and Students Publications

Reconstruction of the eyelid is a complex process that requires an understanding of eyelid anatomy and various reconstructive techniques to restore function and appearance. The eyelids, essential for globe protection, moisture retention, and expression, contain the lacrimal system and intricate musculature that make reconstruction challenging. Tumor excision commonly results in defects in the eyelid that require careful reconstructive planning, with consideration for defect dimensions, location, and involvement of surrounding tissue. This review presents reconstructive techniques commonly used in the management of eyelid defects.

Effects Of The Covid-19 Pandemic On Clinical Manifestations And Therapeutic Outcomes In Acute Endophthalmitis, Ana Maria Dascalu, Sanda Jurja, Carmen Luminita Mocanu, Cristina Alexandrescu, Daniela Stana, Madalina Totir, Ece Ergin, Corneliu Tudor, Catalin Cicerone Grigorescu, Dragos Serban, Laurentiu Simion, Dan Dumitrescu, Andrei Marin, Catalin Teodor Constantinescu, Bogdan Mihai Cristea

Journal of Mind and Medical Sciences

Endophthalmitis incidence and clinical characteristics was reported to change during Covid-19 pandemic, due to multiple influencing factors, such as prolonged lockdown periods, persistent immune suppression following Sars-Cov-2 infection, and mask wearing. We conducted a retrospective eight-year study, during January 2016 and December 2023, that aims to investigates the differences in terms of etiology, clinical characteristics and outcomes in cases with acute endophthalmitis, admitted before (2016-2019) and during Covid-19 pandemic (2020-2023). The two study subgroups were homogenous in term of age, gender distribution, associated comorbidities, and addressability. During Covid-19 pandemic there were significant delays in presentation (p=0.02), more cases of endogenous …

Ocular Myasthenia Gravis; A Case Report, Amy Garbo Maxey Od, Kristin Wilson Od

Optometric Clinical Practice

Abstract

Background: Myasthenia gravis (MG) is an autoimmune disease disorder that affects the skeletal muscles causing increased fatigability and weakness. When it affects the ocular muscles only, it is known as ocular myasthenia gravis (OMG). Patients with OMG will often have symptoms of diplopia and ptosis, which will be worse towards the end of the day. This case report will discuss the common symptoms of OMG as well as the appropriate treatment and management. It will also review the diagnostic tests used to aid in the diagnosis of OMG and discuss the prognosis of OMG. Case Report: A 67-year-old male …

Longitudinal Assessment Of Retinopathy Of Prematurity (Longrop) Study: Impacts Of Viewing Time And Ability To Compare On Detection Of Change, Tatiana R. Rosenblatt, Hashem H. Ghoraba, Marco H. Ji, Caroline R. Baumal, Audina M. Berrocal, Cagri G. Besirli, Kimberly A. Drenser, Anna L. Ells, C. Armitage Harper, G. Baker Hubbard, Eric D. Nudleman, Polly A. Quiram, Irena Tsui, Yoshihiro Yonekawa, Edward H. Wood, Jochen Kumm, Darius M. Moshfeghi

Wills Eye Hospital Papers

PURPOSE: This study compared two imaging grading techniques to assess the utility of longitudinal image-based analysis in retinopathy of prematurity (ROP) screening: (1) time-limited without image comparison (a proxy for bedside indirect ophthalmoscopy, termed sBIO) and time-unlimited with image comparison (for telemedicine grading, termed TELE) screening. We tested two hypotheses: (1) H1: TELE was superior to sBIO for the detection of change (Tempo)-same, better, or worse and (2) H2: granular data of change (e.g., at the image and feature level) is integrated by graders to achieve the Tempo assessment.

DESIGN: Prospective reliability analysis.

METHODS: Gold standard reference (GS) was a …

Umbilical Amniotic Membrane (Am-Uc) As A Skin Substitute In Periocular Reconstruction: A Case Series, Jane Spadaro, Komalpreet Tur, Alon Kahana

Conference Presentation Abstracts

No abstract provided.

Iodine Contrast Should Be Avoided In Patients With Or At Risk For Thyroid Eye Disease, Jane Spadaro, Brittany Simmons, Alon Kahana

Conference Presentation Abstracts

No abstract provided.

Anatomy Of Lower Eyelid Fat Pad Vasculature As Found In Lower Eyelid Blepharoplasties, Irene Lee, Nishita Sheth, Evan Black, Christopher Delmarkarian, Julie Woodward

Conference Presentation Abstracts

No abstract provided.