Multidisciplinary Care In Motor Neuron Disease, Sara Khan

Pakistan Journal of Neurological Sciences (PJNS)

Motor neuron disease (MND) is a progressive degenerative disorder of the motor neurons, resulting in progressive limb, bulbar and respiratory muscle weakness. No definitive disease modifying treatment is available at this time. The mainstay of management remains multidisciplinary care, which has shown to improve quality of life, prevents complications and may also increase life span. In this review, different medical specialties necessary to offer complete multidisciplinary care are discussed. Symptomatic management of individual symptoms commonly experienced by patients with MND is elaborated on.

Retracted: The Epidemiology Of Stroke In A Developing Country (Pakistan), M Ishaq Khan, Junaid I. Khan, Sheikh I. Ahmed, Sajjad Ali

Pakistan Journal of Neurological Sciences (PJNS)

Retraction Notice

Khan MI, Khan JI, Ahmed SI, Ali S. The epidemiology of stroke in a developing country (Pakistan).

Pak J Neurol Sci. 2018;13(3):30-44.

A reader brought to our attention that the article titled “The epidemiology of stroke in a developing country (Pakistan)”, published in Volume 13, Issue 3, of Pakistan Journal of Neurological Sciences (PJNS) was a redundant (duplicate) publication. We investigated this complaint and found out that prior to its submission to PJNS on February 11 2018, this article had already been published almost verbatim in Journal of Neurology & Stroke on January 23, 2018.

Reference of the …

Hemispheric Regional Based Analysis Of Diffusion Tensor Imaging And Diffusion Tensor Tractography In Patients With Temporal Lobe Epilepsy And Correlation With Patient Outcomes., Mahdi Alizadeh, Lauren Kozlowski, Jennifer Muller, Neha Ashraf, Shiva Shahrampour, Feroze B. Mohamed, Chengyuan Wu, Ashwini Sharan

Department of Neurosurgery Faculty Papers

Imaging in the field of epilepsy surgery remains an essential tool in terms of its ability to identify regions where the seizure focus might present as a resectable area. However, in many instances, an obvious structural abnormality is not visualized. This has created the opportunity for new approaches and imaging innovation in the field of epilepsy, such as with Diffusion Tensor Imaging (DTI) and Diffusion Tensor Tractography (DTT). In this study, we aim to evaluate the use of DTI and DTT as a predictive model in the field of epilepsy, specifically Temporal Lobe Epilepsy (TLE), and correlate their clinical significance …

The Carotid Sinus Nerve And The First English Translation Of Hering's Original Research On This Nerve., Mohammadali M Shoja, Rabjot Rai, Stefan Lachkar, Seleipiri Iboroma Akobo, Emre Yilmaz, Marios Loukas, Emanuela Binello, Mehrnoush Gorjaian, Christoph J Griessenauer, Joe Iwanaga, R Shane Tubbs

Articles, Abstracts, and Reports

This paper provides a brief depiction of the life and achievements of the most iconic experiments of Heinrich Ewald Hering. The authors herein have presented a translation of his paper on the carotid sinus nerve in English; the original paper by Heinrich Ewald Hering, titled "Ueber die Wand des Sinus caroticus als Reizempfänger und den Sinusnerv als zentripetale Bahn für die Sinusreflexe" (1924), provides a detailed account of his experimental process and findings. He recognized that the sinus reflexes are mediated by a branch of the glossopharyngeal nerve (CN IX).

Quantitative Clinical And Autoimmune Assessments In Stiff Person Syndrome: Evidence For A Progressive Disorder., Goran Rakocevic, Harry Alexopoulos, Marinos C. Dalakas

Department of Neurology Faculty Papers

BACKGROUND: Stiff Person Syndrome (SPS) is an under-diagnosed disorder that affects mobility and the quality of life of affected patients. The aim of the study is to describe the natural history of SPS, the extent of accumulated disability and the associated clinical and immunological features in patients followed for up to 8 years in a single center.

METHODS: Our collective cohort included 57 SPS patients. Additionally, 32 of these patients were examined every 6 months for a two-year period in a longitudinal study protocol, to assess disease progression using quantitative measures of stiffness and heightened sensitivity.

RESULTS: The most frequent …

What? Not Another Fall!: Reducing Falls In The Neuroscience Patient Population, Elizabeth Plante

Nursing Posters

The purpose of this evidence-based practice project is to reduce the fall rate from 5.52 to less than 4.80 on a Neuroscience/Spine Unit through increasing staff and patient awareness of fall risk and application of evidence-based fall prevention practices of communication, patient involvement and bedside report.

Reducing Falls In The Neuroscience Patient Population, Elizabeth Plante

Nursing Posters

Purpose Statement:

The purpose of this evidence-based practice project is to reduce the fall rate from 5.52 to less than 4.80 on a Neuroscience/Spine Unit through increasing staff and patient awareness of fall risk and application of evidence-based fall prevention practices of communication, patient involvement and bedside report.

Targeting Intracellular Calcium Stores Alleviates Neurological Morbidities In A Dfp-Based Rat Model Of Gulf War Illness, Laxmikant Deshpande, Edna Santos, Kristin Phillips, Robert Blair

Neurology Publications

Gulf War Illness (GWI) is a chronic multi-symptom disorder afflicting the veterans of the First Gulf War, and includes neurological symptoms characterized by depression and memory deficits. Chronic exposure to organophosphates (OP) is considered a leading cause for GWI, yet its pathobiology is not fully understood. We recently observed chronic elevations in neuronal Ca2+ levels ([Ca2+]i) in an OP- diisopropyl fluorophosphate (DFP) based rat model for GWI. This study was aimed at identifying mechanisms underlying elevated [Ca2+]i in this DFP model and investigating whether their therapeutic targeting could improve GWI-like neurological morbidities. Male Sprague-Dawley rats (9-wks) were exposed to DFP …

Response To Misused And Misleading: 100% Response Rate To Galcanezumab In Patients With Episodic Migraine, N. Rosen, E. Pearlman, D. Ruff, K. Day, A. J. Nagy

Journal Articles

No abstract provided.

Tele-Monitored Tdcs Rehabilitation: Feasibility, Challenges And Future Perspectives In Parkinson's Disease, A. Cucca, K. Sharma, S. Agarwal, A. S. Feigin, M. C. Biagioni

Journal Articles

© 2019 The Author(s). Transcranial direct current stimulation (tDCS) is a modality of non-invasive brain stimulation involving the application of low amplitude direct current via surface electrodes on the scalp. tDCS has been studied in healthy populations and in multiple brain disorders and has the potential to be a treatment for several neuropsychiatric conditions by virtue of its capability of influencing cognitive, motor and behavioral processes. tDCS is a generally safe technique when performed within standardized protocols in research or clinical settings. Furthermore, tDCS portability, high acceptability and user-friendly interface makes it highly appealing for telemedicine practices. The term "telemedicine" …

Sex-Related Differences In Homebound Advanced Parkinson's Disease Patients, L. Nwabuobi, W. Barbosa, M. Sweeney, S. Oyler, T. Meisel, A. Di Rocco, J. Chodosh, J. E. Fleisher

Journal Articles

No abstract provided.

Correction To: Sequencing And Curation Strategies For Identifying Candidate Glioblastoma Treatments (Vol 12, 56, 2019), M. O. Frank, T. Koyama, K. Rhrissorrakrai, N. Robine, F. Utro, A. Emde, B. Chen, J. Boockvar, A. Demopoulos, R. B. Darnell, +39 Additional Authors

Journal Articles

No abstract provided.

Prehospital Factors Associated With Discharge Outcomes: Baseline Data From The Andhra Pradesh Traumatic Brain Injury Project, K. Ram, K. Varaprasad, M. K. Krishna, N. Kannan, V. Sundar, M. Joseph, V. D. Sinha, D. Shukla, R. K. Narayan, M. S. Vavilala, +2 Additional Authors

Journal Articles

© 2019 The Authors Objective: Strategies to improve traumatic brain injury (TBI) outcomes in India are ill defined. The objective of this study was to examine baseline prehospital (PH) factors associated with outcomes from the Andhra Pradesh Traumatic Brain Injury Project. Methods: We conducted a prospective observational cohort study of adult patients with TBI admitted to the primary referral hospital. Modes of injury, prehospital care and transport, and factors associated with increased in-hospital mortality were evaluated. Poisson regression with robust error variance and adjusted attributable risk percent estimates determined factors associated with outcomes. Results: A total of 447 adults (38% …

Novel Bioactive And Therapeutic Dental Polymeric Materials To Inhibit Periodontal Pathogens And Biofilms, M. Chi, M. Qi, A. Lan, P. Wang, M. D. Weir, M. A. Melo, X. Sun, B. Dong, C. Li, H. H. Xu, +2 Additional Authors

Journal Articles

© 2019 by the authors. Licensee MDPI, Basel, Switzerland. Periodontitis is a common infectious disease characterized by loss of tooth-supporting structures, which eventually leads to tooth loss. The heavy burden of periodontal disease and its negative consequence on the patient’s quality of life indicate a strong need for developing effective therapies. According to the World Health Organization, 10–15% of the global population suffers from severe periodontitis. Advances in understanding the etiology, epidemiology and microbiology of periodontal pocket flora have called for antibacterial therapeutic strategies for periodontitis treatment. Currently, antimicrobial strategies combining with polymer science have attracted tremendous interest in the …

Adaptation Of The Human Auditory Cortex To Changing Background Noise, B. Khalighinejad, J. L. Herrero, A. D. Mehta, N. Mesgarani

Journal Articles

No abstract provided.

Incins-Igf2 Promotes Cell Proliferation And Migration By Promoting G1/S Transition In Lung Cancer, S. Gao, Z. Lin, C. Li, Y. Wang, L. Yang, B. Zou, J. Chen, J. Li, D. Feng, G. Liu, +1 Additional Author

Journal Articles

© The Author(s) 2019. Long noncoding RNAs are capable of regulating gene expression at multiple levels. These RNA molecules are also involved in a variety of physiological and pathological processes. Emerging data demonstrate that a series of differentially expressed long noncoding RNAs are implicated in tumorigenesis. In the present study, we used microarray analysis to identify long noncoding RNAs that are dysregulated in non-small-cell lung cancer when compared to normal lung tissues. Accordingly, we performed quantitative real-time polymerase chain reaction to analyze the levels of long noncoding RNA and the cis target gene. We further found the oncogene property of …

Efficacy And Safety Of Ozanimod In Multiple Sclerosis: Dose-Blinded Extension Of A Randomized Phase Ii Study, J. A. Cohen, G. Comi, D. L. Arnold, A. Bar-Or, K. W. Selmaj, L. Steinman, E. K. Havrdová, B. A. Cree, B. E. Skolnick, L. Kappos, +4 Additional Authors

Journal Articles

© The Author(s), 2018. Background: Ozanimod, an oral immunomodulator, selectively targets sphingosine 1-phosphate receptors 1 and 5. Objective: Evaluate efficacy, safety, and tolerability of ozanimod in relapsing multiple sclerosis. Methods: In the RADIANCE Part A phase II study (NCT01628393), participants with relapsing multiple sclerosis were randomized (1:1:1) to once-daily ozanimod hydrochloride (0.5 or 1 mg) or placebo. After 24 weeks, participants could enter a 2-year, dose-blinded extension. Ozanimod-treated participants continued their assigned dose; placebo participants were re-randomized (1:1) to ozanimod hydrochloride 0.5 or 1 mg (equivalent to ozanimod 0.46 and 0.92 mg). Results: A total of 223 (89.6%) of the …

Acute Levodopa Dosing Around-The-Clock Ameliorates Rem Sleep Without Atonia In Hemiparkinsonian Rats, Vishakh Iyer, Quynh Vo, Anthony Mell, Siven Chinniah, Ashley Zenerovitz, Kala Venkiteswaran, Allen R. Kunselman, Jidong Fang, Thyagarajan Subramanian

Faculty & Staff Scholarship

• Article
• Open Access
• Published: 29 November 2019

Acute levodopa dosing around-the-clock ameliorates REM sleep without atonia in hemiparkinsonian rats

• Vishakh Iyer,
• Quynh Vo,
• Anthony Mell,
• Siven Chinniah,
• Ashley Zenerovitz,
• Kala Venkiteswaran,
• Allen R. Kunselman,
• Jidong Fang &
• Thyagarajan Subramanian

npj Parkinson's Disease volume 5, Article number: 27 (2019) Cite this article

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Abstract

Rapid-eye-movement (REM) sleep without atonia (RSWA), a marker of REM sleep behavior disorder (RBD), is frequently comorbid with Parkinson’s disease (PD). Although rodent models are commonly used for studying PD, the neurobiological and behavioral correlates of …

Increased Dementia Mortality In West Virginia Counties With Mountaintop Removal Mining?, A. K. Salm, Michael J. Benson

Faculty & Staff Scholarship

(MTM), a practice that has been ongoing in some counties of West Virginia (WV) USA since the 1970s. PM inhalation has been linked to central nervous system pathophysiology, including cognitive decline and dementia. Here we compared county dementia mortality statistics in MTM vs. non-MTM WV counties over a period spanning 2001–2015. We found significantly elevated age-adjusted vascular or unspecified dementia mortality/100,000 population in WV MTM counties where, after adjusting for socioeconomic variables, dementia mortality was 15.60 (±3.14 Standard Error of the Mean (S.E.M.)) times higher than that of non-MTM counties. Further analyses with satellite imaging data revealed a highly significant …

Venous Manometry As An Adjunct For Diagnosis And Multimodal Management Of Intracranial Hypertension Due To Meningioma Compressing Sigmoid Sinus, Cletus Cheyuo, Charles L. Rosen, Ansaar Rai, Christopher P. Cifarelli, Rabia Qaiser

Faculty & Staff Scholarship

Intracranial venous hypertension is a rare presentation of meningiomas in the transversesigmoid sinus region. We describe a case of a young patient presenting with intracranial hypertension due to a meningioma causing compression of the dominant sigmoid sinus. We were able to document the cerebral venous pressure gradient across the lesion confirming our hypothesis that compression of the sigmoid sinus from the meningioma was the cause of intracranial hypertension. The patient is a 17-year-old male who presented with intracranial hypertension due to meningioma at the right dominant sigmoid sinus, which was treated by a Simpson grade IV surgical resection followed by …