Interim Guidance For Basic And Advanced Life Support In Adults, Children, And Neonates With Suspected Or Confirmed Covid-19: From The Emergency Cardiovascular Care Committee And Get With The Guidelines®-Resuscitation Adult And Pediatric Task Forces Of The American Heart Association In Collaboration With The American Academy Of Pediatrics, American Association For Respiratory Care, American College Of Emergency Physicians, The Society Of Critical Care Anesthesiologists, And American Society Of Anesthesiologists: Supporting Organizations: American Association Of Critical Care Nurses And National Ems Physicians., D. P. Edelson, C. Sasson, P. S. Chan, D. L. Atkins, K. Aziz, L. B. Becker, R. A. Berg, S. M. Bradley, S. C. Brooks, A. Topjian, +17 Additional Authors
Journal Articles
No abstract provided.
Gut Microbiota-Derived Indole 3-Propionic Acid Protects Against Radiation Toxicity Via Retaining Acyl-Coa-Binding Protein,
2020
Zucker School of Medicine at Hofstra/Northwell
Gut Microbiota-Derived Indole 3-Propionic Acid Protects Against Radiation Toxicity Via Retaining Acyl-Coa-Binding Protein, H. W. Xiao, M. Cui, Y. Li, J. L. Dong, S. Q. Zhang, C. C. Zhu, M. Jiang, T. Zhu, H. C. Wang, S. J. Fan, +1 Additional Author
Journal Articles
© 2020 The Author(s). Background: We have proved fecal microbiota transplantation (FMT) is an efficacious remedy to mitigate acute radiation syndrome (ARS); however, the mechanisms remain incompletely characterized. Here, we aimed to tease apart the gut microbiota-produced metabolites, underpin the therapeutic effects of FMT to radiation injuries, and elucidate the underlying molecular mechanisms. Results: FMT elevated the level of microbial-derived indole 3-propionic acid (IPA) in fecal pellets from irradiated mice. IPA replenishment via oral route attenuated hematopoietic system and gastrointestinal (GI) tract injuries intertwined with radiation exposure without precipitating tumor growth in male and female mice. Specifically, IPA-treated mice represented …
Erratum: Assessment Of Physician Well-Being, Part Two: Beyond Burnout (Western Journal Of Emergency Medicine (2019) 20:2 (291-304) Doi: 10.5811/Westjem.2019.1.39666),
2020
Zucker School of Medicine at Hofstra/Northwell
Erratum: Assessment Of Physician Well-Being, Part Two: Beyond Burnout (Western Journal Of Emergency Medicine (2019) 20:2 (291-304) Doi: 10.5811/Westjem.2019.1.39666), M. D. Lall, T. J. Gaeta, A. S. Chung, S. A. Chinai, M. Garg, A. Husain, C. Kanter, S. Khandelwal, C. S. Rublee, N. T. Himelfarb, +3 Additional Authors
Journal Articles
© 2020 eScholarship. All rights reserved. Part One of this two-article series reviews assessment tools to measure burnout and other negative states. Physician well-being goes beyond merely the absence of burnout. Transient episodes of burnout are to be expected. Measuring burnout alone is shortsighted. Well-being includes being challenged, thriving, and achieving success in various aspects of personal and professional life. In this second part of the series, we identify and describe assessment tools related to wellness, quality of life, resilience, coping skills, and other positive states.
Ultrasound On The Frontlines Of Covid-19: Report From An International Webinar,
2020
Zucker School of Medicine at Hofstra/Northwell
Ultrasound On The Frontlines Of Covid-19: Report From An International Webinar, R. B. Liu, V. S. Tayal, N. L. Panebianco, Y. Tung-Chen, A. Nagdev, S. Shah, E. Pivetta, P. C. Henwood, M. J. Nelson, C. L. Moore
Journal Articles
No abstract provided.
Targeting Inflammation Driven By Hmgb1,
2020
Zucker School of Medicine at Hofstra/Northwell
Targeting Inflammation Driven By Hmgb1, H. Yang, H. Wang, U. Andersson
Journal Articles
© Copyright © 2020 Yang, Wang and Andersson. High mobility group box 1 (HMGB1) is a highly conserved, nuclear protein present in all cell types. It is a multi-facet protein exerting functions both inside and outside of cells. Extracellular HMGB1 has been extensively studied for its prototypical alarmin functions activating innate immunity, after being actively released from cells or passively released upon cell death. TLR4 and RAGE operate as the main HMGB1 receptors. Disulfide HMGB1 activates the TLR4 complex by binding to MD-2. The binding site is separate from that of LPS and it is now feasible to specifically interrupt …
The Role Of Type 1 Interferons In Coagulation Induced By Gram-Negative Bacteria,
2020
Zucker School of Medicine at Hofstra/Northwell
The Role Of Type 1 Interferons In Coagulation Induced By Gram-Negative Bacteria, X. Yang, X. Cheng, Y. Tang, X. Qiu, Z. Wang, G. Fu, J. Wu, H. Kang, H. Wang, B. Lu, +4 Additional Authors
Journal Articles
No abstract provided.
Public Knowledge And Attitudes Towards Bystander Cardiopulmonary Resuscitation (Cpr) In Ghana, West Africa.,
2020
Zucker School of Medicine at Hofstra/Northwell
Public Knowledge And Attitudes Towards Bystander Cardiopulmonary Resuscitation (Cpr) In Ghana, West Africa., M. Anto-Ocrah, N. Maxwell, J. Cushman, E. Acheampong, R. Kodam, C. Homan, T. Li
Journal Articles
BACKGROUND AND OBJECTIVES:Early bystander cardiopulmonary resuscitation (CPR) is one of the most important predictors of out-of-hospital cardiac arrests (OHCA) survival. There is a dearth of literature on CPR engagement in countries such as Ghana, where cardiovascular events are increasingly prevalent. In this study, we sought to evaluate Ghanaians' knowledge of and attitudes towards bystander CPR, in the context of the country's nascent emergency medicine network. METHODS:Capitalizing on the growing ubiquity and use of social media across the country, we used a novel social media sampling strategy for this study. We created, pre-tested, and distributed an online survey, using the two …
Ultrasound Identification Of Retrobulbar Hematomas By Emergency Physicians In A Cadaveric Model,
2020
Zucker School of Medicine at Hofstra/Northwell
Ultrasound Identification Of Retrobulbar Hematomas By Emergency Physicians In A Cadaveric Model, E. Carlin, A. Palmieri, T. Bajaj, M. Nelson
Journal Articles
Copyright: © 2020 Carlin et al. This is an open access article distributed in accordance with the terms of the Creative Commons Attribution (CC BY 4.0) License. See: http://creativecommons.org/licenses/by/4.0/ Introduction: Retrobulbar hemorrhage (RBH) is a rare complication of facial trauma that can lead to dangerous orbital compartment pressures and must be rapidly recognized to prevent permanent vision loss. Point-of-care ultrasound (POCUS) offers a rapid modality for evaluating a wide variety of ocular pathologies, and prior case reports demonstrate the ability of clinicians to recognize RBH using ultrasound. This study aimed to assess the ability of clinicians at various stages of …
Machine Learning To Assist Clinical Decision-Making During The Covid-19 Pandemic.,
2020
Northwell Health
Machine Learning To Assist Clinical Decision-Making During The Covid-19 Pandemic., S. Debnath, D. P. Barnaby, K. Coppa, A. Makhnevich, E. J. Kim, S. Chatterjee, V. Tóth, T. J. Levy, M. D. Paradis, S. L. Cohen, J. S. Hirsch, T. P. Zanos, Northwell Covid-19 Research Consortium
Journal Articles
Background:The number of cases from the coronavirus disease 2019 (COVID-19) global pandemic has overwhelmed existing medical facilities and forced clinicians, patients, and families to make pivotal decisions with limited time and information. Main body:While machine learning (ML) methods have been previously used to augment clinical decisions, there is now a demand for "Emergency ML." Throughout the patient care pathway, there are opportunities for ML-supported decisions based on collected vitals, laboratory results, medication orders, and comorbidities. With rapidly growing datasets, there also remain important considerations when developing and validating ML models. Conclusion:This perspective highlights the utility of evidence-based prediction tools in …
Monoclonal Antibodies Capable Of Binding Sars-Cov-2 Spike Protein Receptor Binding Motif Specifically Prevent Gm-Csf Induction.,
2020
Zucker School of Medicine at Hofstra/Northwell
Monoclonal Antibodies Capable Of Binding Sars-Cov-2 Spike Protein Receptor Binding Motif Specifically Prevent Gm-Csf Induction., X. Qiang, S. Zhu, J. Li, P. Wang, K. J. Tracey, H. Wang
Journal Articles
A severe acute respiratory syndrome (SARS)-like coronavirus (SARS-CoV-2) has recently caused a pandemic COVID-19 disease that infected more than 25.6 million and killed 852,000 people worldwide. Like the SARS-CoV, SARS-CoV-2 also employs a receptor-binding motif (RBM) of its envelope spike protein for binding the host angiotensin-converting enzyme 2 (ACE2) to gain viral entry. Currently, extensive efforts are being made to produce vaccines against a surface fragment of a SARS-CoV-2, such as the spike protein, in order to boost protective antibody responses. It was previously unknown how spike protein-targeting antibodies would affect innate inflammatory responses to SARS-CoV-2 infections. Here we generated …
The Irresponsible Use Of Social Media Among Medical Students,
2020
Zucker School of Medicine at Hofstra/Northwell
The Irresponsible Use Of Social Media Among Medical Students, M. Curato, A. Husain, K. Shah, M. Kanter, D. Egan, H. Thompson, M. Silverberg, M. Jones, T. Dulani, P. Mukherji, +8 Additional Authors
Journal Articles
No abstract provided.
Potential Impacts Of A Novel Integrated Extracorporeal-Cpr Workflow Using An Interventional Radiology And Immediate Whole-Body Computed Tomography System In The Emergency Department,
2020
Northwell Health
Potential Impacts Of A Novel Integrated Extracorporeal-Cpr Workflow Using An Interventional Radiology And Immediate Whole-Body Computed Tomography System In The Emergency Department, K. Hayashida, T. Kinoshita, K. Yamakawa, S. J. Miyara, L. B. Becker, S. Fujimi
Journal Articles
Extracorporeal cardiopulmonary resuscitation (ECPR) can be associated with increased survival and neurologic benefits in selected patients with out-of-hospital cardiac arrest (OHCA). However, there remains insufficient evidence to recommend the routine use of ECPR for patients with OHCA. A novel integrated trauma workflow concept that utilizes a sliding computed tomography (CT) scanner and interventional radiology (IR) system, named a hybrid emergency room system (HERS), allowing emergency therapeutic interventions and CT examination without relocating trauma patients, has recently evolved in Japan. HERS can drastically shorten the ECPR implementation time and more quickly facilitate definitive interventions than the conventional advanced cardiovascular life support …
Mechanical, Team-Focused, Video-Reviewed Cardiopulmonary Resuscitation Improves Return Of Spontaneous Circulation After Emergency Department Implementation,
2020
Zucker School of Medicine at Hofstra/Northwell
Mechanical, Team-Focused, Video-Reviewed Cardiopulmonary Resuscitation Improves Return Of Spontaneous Circulation After Emergency Department Implementation, D. M. Rolston, T. Li, C. Owens, G. Haddad, T. J. Palmieri, V. Blinder, J. L. Wolff, M. Cassara, Q. Zhou, L. B. Becker
Journal Articles
No abstract provided.
Idiopathic Bilateral Internal Jugular Vein Thrombosis Diagnosed By Point-Of-Care Ultrasound.,
2020
Northwell Health
Idiopathic Bilateral Internal Jugular Vein Thrombosis Diagnosed By Point-Of-Care Ultrasound., V. M. Aquino-Jose, J. Johnson, T. Dulani
Journal Articles
Internal jugular vein (IJV) thrombosis is an unusual condition, especially when it develops bilaterally. This is a case of bilateral IJV thrombosis in a 77-year old female who presented to the emergency department with neck and arm swelling after discontinuing apixaban and undergoing an oropharyngeal procedure. The diagnosis of bilateral IJV thrombosis was made with the use of point-of-care ultrasound to evaluate bilateral jugular vein distention and bilateral upper extremity pitting edema found on her physical examination.
Time To Intra-Arrest Therapeutic Hypothermia In Out-Of-Hospital Cardiac Arrest Patients And Its Association With Neurologic Outcome: A Propensity Matched Sub-Analysis Of The Princess Trial,
2020
Zucker School of Medicine at Hofstra/Northwell
Time To Intra-Arrest Therapeutic Hypothermia In Out-Of-Hospital Cardiac Arrest Patients And Its Association With Neurologic Outcome: A Propensity Matched Sub-Analysis Of The Princess Trial, A. Awad, F. S. Taccone, M. Jonsson, S. Forsberg, J. Hollenberg, A. Truhlar, M. Ringh, B. S. Abella, L. B. Becker, P. Nordberg, +2 Additional Authors
Journal Articles
© 2020, The Author(s). Purpose: To study the association between early initiation of intra-arrest therapeutic hypothermia and neurologic outcome in out-of-hospital cardiac arrest. Methods: A prespecified sub-analysis of the PRINCESS trial (NCT01400373) that randomized 677 bystander-witnessed cardiac arrests to transnasal evaporative intra-arrest cooling initiated by emergency medical services or cooling started after hospital arrival. Early cooling (intervention) was defined as intra-arrest cooling initiated < 20 min from collapse (i.e., ≤ median time to cooling in PRINCESS). Propensity score matching established comparable control patients. Primary outcome was favorable neurologic outcome, Cerebral Performance Category (CPC) 1–2 at 90 days. Complete recovery (CPC 1) was among secondary outcomes. Results: In total, 300 patients were analyzed and the proportion with CPC 1–2 at 90 days was 35/150 (23.3%) in the intervention group versus 24/150 (16%) in the control group, odds ratio (OR) 1.92, 95% confidence interval (CI) 0.95–3.85, p =.07. In patients with shockable rhythm, CPC 1–2 was 29/57 (50.9%) versus 17/57 (29.8%), OR 3.25, 95%, CI 1.06–9.97, p =.04. The proportion with CPC 1 at 90 days was 31/150 (20.7%) in the intervention group and 17/150 (11.3%) in controls, OR 2.27, 95% CI 1.12–4.62, p =.02. In patients with shockable rhythms, the proportion with CPC 1 was 27/57 (47.4%) versus 12/57 (21.1%), OR 5.33, 95% CI 1.55–18.3, p =.008. Conclusions: In the whole study population, intra-arrest cooling initiated < 20 min from collapse compared to cooling initiated at hospital was not associated with improved favorable neurologic outcome. In the subgroup with shockable rhythms, early cooling was associated with improved favorable outcome and complete recovery.
Spontaneous Pneumothorax As A Complication Of Covid-19 Pneumonia: A Case Report.,
2020
Northwell Health
Spontaneous Pneumothorax As A Complication Of Covid-19 Pneumonia: A Case Report., L. Perice, Z. Roit, I. Llovera, M. G. Flanagan-Kundle
Journal Articles
INTRODUCTION:Coronavirus disease 2019 (COVID-19) is caused by the severe acute respiratory syndrome coronavirus 2. It typically presents with respiratory symptoms such as fevers, cough, and shortness of breath. As the number of cases increases, however, COVID-19 is being increasingly recognized as being associated with a variety of other respiratory pathologies. CASE REPORT:We present the case of a 59-year-old man with COVID-19 pneumonia who acutely decompensated after having been on the medicine floor for two weeks. He was found to have a tension pneumothorax. This was treated with a needle decompression followed by a chest tube insertion. The patient subsequently recovered …
Man With Foot Pain,
2020
Zucker School of Medicine at Hofstra/Northwell
Man With Foot Pain, B. Hahn, D. Langhan, D. Miller, J. Greenstein
Journal Articles
No abstract provided.
Presenting Characteristics, Comorbidities, And Outcomes Among 5700 Patients Hospitalized With Covid-19 In The New York City Area,
2020
Zucker School of Medicine at Hofstra/Northwell
Presenting Characteristics, Comorbidities, And Outcomes Among 5700 Patients Hospitalized With Covid-19 In The New York City Area, S Richardson, Js Hirsch, M Narasimhan, Jm Crawford, T Mcginn, Kw Davidson, Northwell Covid-19 Research Consortium
Journal Articles
No abstract provided.
Escape The Trauma Room,
2020
Northwell Health
Escape The Trauma Room, M. Podlog, A. Husain, J. Greenstein, S. Sanghvi
Journal Articles
© 2019 by the Society for Academic Emergency Medicine Traditional conference didactics may not be effectively meeting the learning needs of today's emergency medicine (EM) residents, and educators are employing various interactive approaches to engage learners. Escape Room is a popular adventure game in which participants must work together to solve a series of puzzles to escape a locked room. Our aim was to adapt this game design to teach core EM content and procedural aptitude. Upon entering the “locked” room residents were faced with a series of puzzles involving concepts such as toxicology antidotes, ventilator management, echocardiogram interpretations, airway …
Intention To Leave Emergency Medicine: Mid-Career Women Are At Increased Risk,
2020
Zucker School of Medicine at Hofstra/Northwell
Intention To Leave Emergency Medicine: Mid-Career Women Are At Increased Risk, M. D. Lall, S. M. Perman, N. Garg, N. Kohn, K. Whyte, A. Gips, T. Madsen, J. M. Baren, J. Linden
Journal Articles
No abstract provided.
