Cardiology Commons^™

Cardioversion Of Persistent Atrial Fibrillation Before High Energy Ablation Does Not Improve Outcomes In Short Term Follow Up: Preliminary Analysis, Ruifang Yang Md, Sokol Kalaveshi Md, David Goldgrab Do, Jose Luis Henao Md, Stephen Mester Md, Christian Perzanowski Md

Cardiology

Introduction | Objectives: The optimal approach of ablating persistent Atrial Fibrillation (peAF) has yet to be defined. By convention, mapping/ablation of peAF is most often performed in AF. The success of ablation hinges on catheter contact and achieving lesion transmurality. We theorized that ablation efficacy would improve during sinus rhythm (SR) given stability and predictability of catheter contact.

Methods: Non‐randomized comparison of peAF patients who underwent ablation in SR under a new practice protocol versus a cohort of peAF ablated in AF. The lesion set was the same for both groups, WACA ± BOX. Study group was treated with higher …

A Case Of Blunt Trauma-Induced St-Elevation Myocardial Infarction Sustained During A Prison Brawl., Zachary T Clark, Natalie Thiel, John Perry, Michael R Minckler

Articles, Abstracts, and Reports

Myocardial infarction (MI) is a serious and time-sensitive condition. MIs are typically seen in patients with coronary artery disease (CAD) and are caused by the rupture of an atherosclerotic plaque due to factors contributing to plaque instability. However, this case illustrates that plaque rupture can also be caused by blunt trauma to the chest. Considering MI as a possible result of chest trauma may decrease time from presentation to diagnosis and treatment and, therefore, improve outcomes in similar cases, particularly when patients presents unusually or with very few risk factors for MI.

Implications Of C1q/Tnf-Related Protein Superfamily In Patients With Coronary Artery Disease., Yanwei Zhang, Caihong Liu, Jing Liu, Rui Guo, Zheyi Yan, Wenxia Liu, Wayne Bond Lau, Xiangying Jiao, Jimin Cao, Kun Xu, Yongping Jia, Xin-Liang Ma, Yajing Wang

Department of Emergency Medicine Faculty Papers

The C1q complement/TNF-related protein superfamily (CTRPs) displays differential effects on the regulation of metabolic homeostasis, governing cardiovascular function. However, whether and how they may serve as predictor/pro-diagnosis factors for assessing the risks of coronary artery disease (CAD) remains controversial. Therefore, we performed a clinical study to elaborate on the implication of CTRPs (CTRP1, CTRP5, CTRP7, and CTRP15) in CAD. CTRP1 were significantly increased, whereas CTRP7 and CTRP15 levels were decreased in CAD patients compared to the non-CAD group. Significant differences in CTRP1 levels were discovered between the single- and triple-vascular-vessel lesion groups. ROC analysis revealed that CTRP7 and CTRP15 may …

Evidence For The Misfolding Of The A1 Domain Within Multimeric Von Willebrand Factor In Type 2 Von Willebrand Disease, Alexander Tischer, Maria A Brehm, Venkata R Machha, Laurie Moon-Tasson, Linda M Benson, Katelynn J Nelton, Rachel R Leger, Tobias Obser, Marina Martinez-Vargas, Steven T Whitten, Dong Chen, Rajiv K Pruthi, H Robert Bergen, Miguel A Cruz, Reinhard Schneppenheim, Matthew Auton

Faculty, Staff and Students Publications

Von Willebrand factor (VWF), an exceptionally large multimeric plasma glycoprotein, functions to initiate coagulation by agglutinating platelets in the blood stream to sites of vascular injury. This primary hemostatic function is perturbed in type 2 dysfunctional subtypes of von Willebrand disease (VWD) by mutations that alter the structure and function of the platelet GPIbα adhesive VWF A1 domains. The resulting amino acid substitutions cause local disorder and misfold the native structure of the isolated platelet GPIbα-adhesive A1 domain of VWF in both gain-of-function (type 2B) and loss-of-function (type 2M) phenotypes. These structural effects have not been explicitly observed in A1 …

Spotlight On Icosapent Ethyl For Cardiovascular Risk Reduction: Evidence To Date, Xiaoming Jia, Stephanie Koh, Mahmoud Al Rifai, Roger S. Blumenthal, Salim S. Virani

Office of the Provost

Icosapent ethyl is a highly purified formulation of eicosapentaenoic acid, a type of omega-3 fatty acid contained in fish oil. While omega-3 fatty acids have long been thought to have cardioprotective benefits, the Reduction of Cardiovascular Events with EPA-Intervention Trial (REDUCE-IT) has helped to establish icosapent ethyl as an evidence-based therapy for risk reduction of atherosclerotic cardiovascular disease (ASCVD). REDUCE-IT, however, was by no means an overnight success story. Close examination of the evidence shows that the trial was a culmination of many lessons learned from previous studies. The purpose of this manuscript is to review contemporary evidence of icosapent …

Sevoflurane Pre-Conditioning Ameliorates Diabetic Myocardial Ischemia/Reperfusion Injury Via Differential Regulation Of P38 And Erk., Dina Xie, Jianli Zhao, Rui Guo, Liyuan Jiao, Yanqing Zhang, Wayne Bond Lau, Bernard Lopez, Theodore Christopher, Erhe Gao, Jimin Cao, Xin-Liang Ma, Yajing Wang

Department of Emergency Medicine Faculty Papers

Diabetes mellitus (DM) significantly increases myocardial ischemia/reperfusion (MI/R) injury. During DM, cardioprotection induced by conventional pre-conditioning (PreCon) is decreased due to impaired AMP-activated protein kinase (AMPK) signaling. The current study investigated whether PreCon with inhaled anesthetic sevoflurane (SF-PreCon) remains cardioprotective during DM, and identified the involved mechanisms. Normal diet (ND) and high-fat diet (HFD)-induced DM mice were randomized into control and SF-PreCon (3 cycles of 15-minute period exposures to 2% sevoflurane) groups before MI/R. SF-PreCon markedly reduced MI/R injury in DM mice, as evidenced by improved cardiac function (increased LVEF and ±Dp/dt), decreased infarct size, and decreased apoptosis. To determine …

Prevalence Of Sensorineural Hearing Loss In Children With Palliated Or Repaired Congenital Heart Disease., Lalitha Gopineti, Mane Paulpillai, Andrea Rosenquist, Andrew H. Van Bergen

Manuscripts, Articles, Book Chapters and Other Papers

Background Children with congenital heart disease (CHD) are at increased risk of neurodevelopmental deficits, and the presence of sensorineural hearing loss (SNHL) may further lead to poor language skills acquisition and speech delays. Prevalence of SNHL in the general pediatric population is estimated to be 0.2% at birth to 0.35% during adolescence. Very few studies have attempted to estimate SNHL prevalence in children who have undergone congenital heart surgery. Methods This retrospective study aimed to estimate SNHL prevalence in children who underwent congenital heart surgery in our institution and were followed up in our high-risk pediatric cardiology clinics for four …

Reduction In St-Segment Elevation Cardiac Catheterization Laboratory Activations In The United States During Covid-19 Pandemic, S Garcia, Ms Albaghdadi, Pm Meraj, C Schmidt, R Garberich, Fa Jaffer, S Dixon, Jj Rade, M Tannenbaum, Td Henry, +2 Additional Authors

Journal Articles

No abstract provided.

Guidance For Rebooting Electrophysiology Through The Covid-19 Pandemic From The Heart Rhythm Society And The American Heart Association Electrocardiography And Arrhythmias Committee Of The Council On Clinical Cardiology., Dr Lakkireddy, Mk Chung, Tf Deering, R Gopinathannair, Cm Albert, Lm Epstein, Cv Harding, Jl Hurwitz, Cc Jeffery, Mj Shah, +9 Additional Authors

Journal Articles

No abstract provided.

Incidence Of Arrhythmias And Electrocardiographic Abnormalities In Symptomatic Pediatric Patients With Pcr-Positive Sars-Cov-2 Infection, Including Drug-Induced Changes In The Corrected Qt Interval, S Samuel, Ra Friedman, C Sharma, M Ganigara, E Mitchell, C Schleien, Ad Blaufox

Journal Articles

No abstract provided.

Life Interrupted: On The Front Lines With Covid-19, E Argulian, Jw Weinsaft, Rc Hendel, Vp Garg, J Kim, Lm Phillips, J H. Mieres, A Abidov, R Blankstein, J Narula, +1 Additional Author

Journal Articles

No abstract provided.

Spontaneous Coronavirus Disease 2019 (Covid-19)-Associated Luminal Aortic Thrombus, C Mullan, C Powierza, Pe Miller, A Geirsson, P Vallabhajosyula, R Assi

Journal Articles

No abstract provided.

Cardiac Catheterization Laboratory Volume Changes During Covid-19—Findings From A Cardiovascular Fellows Consortium, S. Kadavath, J. Mohan, S. Ashraf, A. Kassier, D. Hawwass, N. Madan, N. Salehi, M. Bernardo, M. C. Kim, M. C. Alraies, +13 Additional Authors

Journal Articles

No abstract provided.

Usefulness Of Elevated Troponin To Predict Death In Patients With Covid-19 And Myocardial Injury., D. T. Majure, L. Gruberg, S. G. Saba, C. Kvasnovsky, J. S. Hirsch, R. Jauhar, Northwell Health Covid-19 Research Consortium

Journal Articles

Elevations in troponin levels have been shown to predict mortality in patients with coronavirus disease 2019 (COVID-19). The role of inflammation in myocardial injury remains unclear. We sought to determine the association of elevated troponin with mortality in a large, ethnically diverse population of patients hospitalized with COVID-19, and to determine the association of elevated inflammatory markers with increased troponin levels. We reviewed all patients admitted at our health system with COVID-19 from March 1 to April 27, 2020, who had a troponin assessment within 48 hours of admission. We used logistic regression to calculate odds ratios (ORs) for mortality …

Hrs/Ehra/Aphrs/Lahrs/Acc/Aha Worldwide Practice Update For Telehealth And Arrhythmia Monitoring During And After A Pandemic, N. Varma, N. F. Marrouche, L. Aguinaga, C. M. Albert, E. Arbelo, J. I. Choi, M. K. Chung, G. Conte, L. M. Epstein, P. D. Varosy, +13 Additional Authors

Journal Articles

No abstract provided.

Interrupting Microaggressions In Health Care Settings: A Guide For Teaching Medical Students, R. G. Acholonu, T. E. Cook, R. O. Roswell, R. E. Greene

Journal Articles

© 2020 Acholonu et al. Introduction: Microaggressions are connected to broader conceptualizations of the impact of implicit bias and systems of inequity. The body of evidence supporting the need for more-open discussions in medical education about race, racism, and their impact on health disparities continues to grow. Some have advocated for the importance of bringing anti-racist pedagogy into medical education curricula, which involves explicitly attempting to move beyond people's comfort zones and acknowledging that discomfort can be a catalyst for growth. To discuss the intent and impact of microaggressions in health care settings and how we might go about responding …

Cryoballoon Ablation Of Pulmonary Veins For Persistent Atrial Fibrillation: Results From The Multicenter Stop Persistent Af Trial, W. W. Su, V. Y. Reddy, K. Bhasin, J. Champagne, R. M. Sangrigoli, K. M. Braegelmann, F. J. Kueffer, P. Novak, S. K. Gupta, H. Calkins, +1 Additional Author

Journal Articles

No abstract provided.

Takotsubo Syndrome And Covid-19: Associations And Implications., R. M. Shah, M. Shah, S. Shah, A. Li, S. Jauhar

Journal Articles

Incidence of cardiovascular complications has increased during the COVID-19 (Coronavirus disease 2019) pandemic, both population-wide and in patients diagnosed with the disease. This increase has presented complications in patient care, leading to increased hospitalizations, adverse outcomes, and medical costs. A condition of interest is takotsubo syndrome, which may be associated with the novel coronavirus. To understand this connection, a narrative review was performed by analyzing primary studies and case reports available. The findings showed increased incidence of takotsubo cardiomyopathy in both the general population and COVID-19 patients. Proposed mechanisms for the linkage include generalized increases in psychological distress, the cytokine …

Effect Of Depression Screening After Acute Coronary Syndromes On Quality Of Life The Codiacs-Qol Randomized Clinical Trial, I. M. Kronish, N. Moise, Y. K. Cheung, G. N. Clarke, R. J. Dolor, J. Duer-Hefele, K. L. Margolis, T. St Onge, F. Parsons, K. W. Davidson, +2 Additional Authors

Journal Articles

No abstract provided.

Hrs/Ehra/Aphrs/Lahrs/Acc/Aha Worldwide Practice Update For Telehealth And Arrhythmia Monitoring During And After A Pandemic., N. Varma, N. F. Marrouche, L. Aguinaga, C. M. Albert, E. Arbelo, J. Choi, M. K. Chung, G. Conte, L. M. Epstein, P. D. Varosy, +13 Additional Authors

Journal Articles

No abstract provided.