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Articles 78451 - 78480 of 658456

Full-Text Articles in Social and Behavioral Sciences

Dietary Regulation Of Silent Synapses In The Dorsolateral Striatum, Allison M. Meyers Sep 2022

Dietary Regulation Of Silent Synapses In The Dorsolateral Striatum, Allison M. Meyers

Dissertations, Theses, and Capstone Projects

Obesity and drugs of abuse share overlapping neural circuits and behaviors. Cravings for drugs of abuse increase during abstinence, a phenomenon known as incubation. In obesity, increased craving is observed in individuals during dieting. Diets often fail, with return to- or increase above- original weight. The extent to which this reflects an incubation phenomenon has not been carefully examined. One mechanism underlying incubation is the reemergence of a developmental mechanism called silent synapses. Silent synapses are 'temporary' synapses that are important for remodeling brain circuits. They are prevalent during early development but largely disappear by adulthood. Drugs of abuse increase …


Virtual Reality Supplement To The Peers Social Skills Intervention For Adolescents With Asd, Kevin Ambrose Sep 2022

Virtual Reality Supplement To The Peers Social Skills Intervention For Adolescents With Asd, Kevin Ambrose

Dissertations, Theses, and Capstone Projects

The purpose of this study was to replicate findings of the Program for the Education and Enrichment of Relation Skills (PEERS) parent-assisted social skills training program for a diverse group of adolescents with historical autism spectrum disorder (ASD) diagnoses in an urban locality. Additionally, this study sought to pilot a 3D multi-user virtual environment for adolescent participants and an online learning community for parent coaches; both hypothesized to reinforce the social skills curriculum. A randomized controlled trial of PEERS was completed with 12 adolescents diagnosed with ASD with some participation from their caregivers. Results show that participants who received the …


Linguistic Abstractions In Children’S Very Early Utterances, Qihui Xu Sep 2022

Linguistic Abstractions In Children’S Very Early Utterances, Qihui Xu

Dissertations, Theses, and Capstone Projects

How early do children produce multiword utterances? Do children's early utterances reflect abstract syntactic knowledge or are they the result of data-driven learning? We examine this issue through corpus analysis, computational modeling, and adult simulation experiments. Chapter 1 investigates when children start producing multiword utterances; we use corpora to establish the development of multiword utterances and a probabilistic computational model to account for the quantitative change of early multiword utterances. We find that multiword utterances of different lengths appear early in acquisition and increase together, and the length growth pattern can be viewed as a probabilistic and dynamic process.

Chapter …


Oxytocin, A Lover And A Fighter: Maternal Trauma Exposure And Mother-Child Coregulation, Patricia M. Pehme Sep 2022

Oxytocin, A Lover And A Fighter: Maternal Trauma Exposure And Mother-Child Coregulation, Patricia M. Pehme

Dissertations, Theses, and Capstone Projects

The placenta is responsible for regulating the fetal growth and environment in preparation for the anticipated external life. To succeed, it continuously adapts and weaves in a variety of neuroendocrine signals from the maternal organism. If a mother was exposed to trauma and her physiology sustained a change in the functioning of the immune, autonomic and/or endocrine systems, the placenta may anticipate different external environments for her children as compared to children of mothers without trauma exposure. This dissertation examined possible underlying mechanisms of psychosocial trauma transmission from one generation to the next via the placental oxytocinergic pathway. Encompassing three …


The Euro And Bumps In The Road: Historical Patterns Of Nonresident Holdings In Eurozone Bonds, 1980–2018, Michael H. Scarlatos Sep 2022

The Euro And Bumps In The Road: Historical Patterns Of Nonresident Holdings In Eurozone Bonds, 1980–2018, Michael H. Scarlatos

Dissertations, Theses, and Capstone Projects

A developed bond market which attracts nonresident investors both enables and reflects a host currency’s transition from domestic to international status. My analysis of historical private nonresident holdings of Eurozone portfolio debt securities spanning the euro’s 1999 creation and its subsequent 2008 crisis reveals diverging patterns.

This analysis, complemented by coefficient stability tests, discovers that the conversion of national currencies to the euro was reflected by a pickup in nonresident holdings of bonds issued by countries adopting the euro, especially those of the periphery (Portugal, Ireland, Italy and Spain) relative to the core (Germany, Austria, Belgium, Finland, France, and the …


The Moral Economy Of Ordinary Belarussians And A Critical Examination And Re-Evaluation Of The 2020 Post-Electoral Uprising, Geoffrey Blank Sep 2022

The Moral Economy Of Ordinary Belarussians And A Critical Examination And Re-Evaluation Of The 2020 Post-Electoral Uprising, Geoffrey Blank

Dissertations, Theses, and Capstone Projects

This study is three studies in one: First, a qualitative study of the moral economy of ordinary Belarussians based on E.P Thompson’s class-based economic conception of moral economy, as applied to complex socio-economic systems by Reinarman (1987). Second, a critical and broad examination and re-evaluation of the August 9, 2020 post-electoral uprising. And third, an examination of both the West’s hostility toward Belarus’ largely state-owned socially-oriented economic model (often considered market socialism) and toward President Lukashenka, and, of the West’s commitment to overthrowing President Lukashenka and Belarus’ largely state-owned socially-oriented economic model, through its sponsorship of color revolution, “democratization,” regime …


A Queens Community Teacher Storytelling Project: A Qualitative Research Study Of Five Local Afro-Caribbean And Latina Public School Teachers And Community Teachers In New York City, José Alfredo Menjivar Ortéz Sep 2022

A Queens Community Teacher Storytelling Project: A Qualitative Research Study Of Five Local Afro-Caribbean And Latina Public School Teachers And Community Teachers In New York City, José Alfredo Menjivar Ortéz

Dissertations, Theses, and Capstone Projects

This dissertation thesis examines the lived experiences, life stories, and storytelling of five Afro-Caribbean and Latina people, who are all local from the borough of Queens, alumni of New York City’s public schools, and since then, became their local public school teachers, classroom practitioners, and local community teachers. We refer to this specific and unique population of teachers as alumni-community teachers and to these and other similar stories as teacher life stories.

This qualitative research and study were conducted through a series of writing workshops and semi-structured interviews. The study’s main examination is preoccupied to understand how local teachers make …


The International Academy Of Language And Culture: The Global (Pre)K-12 Charter School Network, Dree-El Simmons Sep 2022

The International Academy Of Language And Culture: The Global (Pre)K-12 Charter School Network, Dree-El Simmons

Dissertations, Theses, and Capstone Projects

The International Academy of Language and Culture (IALC) is a charter school based on the original concept of charter schools by Ray Budde and Albert Shanker, as an academic environment dedicated and designed to improving the educational outcomes for its students through innovative pedagogy. Committed to American (and global) education reform, the IALC incorporates elements from higher education into the early childhood and adolescent settings. We accomplish this by utilizing an interdisciplinary approach in our language and culture-based program.

The IALC is a multilingual, full-immersion program. Food Studies (including culinary arts), the Arts, the Humanities, Social Sciences, and Martial Arts …


El Poder De Las Tierras Estatales: Conflictos De Propiedad, Formaciones Estatales Y La Construcción De Los Llanos En Colombia, Julio Arias Vanegas Sep 2022

El Poder De Las Tierras Estatales: Conflictos De Propiedad, Formaciones Estatales Y La Construcción De Los Llanos En Colombia, Julio Arias Vanegas

Dissertations, Theses, and Capstone Projects

This work examines different conflicts over the definition, delimitation, and use of state lands in Colombia. It focuses on the conflicts over three places, which have been produced as state properties and “baldíos” (public, untitled lands) from the 1940s to the 2010s in Los Llanos region. This dissertation departs from two premises. First, the making and unmaking of state lands are unique windows to examine how the limits between state and non-state properties, actors, and spaces are defined and disputed. Second, state lands, and especially baldíos, have been a key form of state territorialization and appropriation of marginalized regions. Thus, …


Policy Evaluation Of The Role Of Extracurricular Activities On Students' Character Building And Academic Excellence: A Case Study Of Cairo's Schools, Nanis Yousry Sep 2022

Policy Evaluation Of The Role Of Extracurricular Activities On Students' Character Building And Academic Excellence: A Case Study Of Cairo's Schools, Nanis Yousry

Theses and Dissertations

The Education policies have usually been given the highest priority globally. This research reflects that the Egyptian educational system currently faces a bottleneck in applying its policies due to significant budgetary constraints. This is seen in public schools, unlike international ones. The research compares and contrasts three educational systems (public, community and international) with the purpose of examining the impact of policy processes on education. This thesis aims to explore how far the existence of extracurricular activities, as a component that complements academic education, is capable of supporting students to acquire the 21st century life skills and fulfill some of …


Citation Sources For Legal Scholarship: Ranking The Top 28 Law Faculties, John R. Beatty Sep 2022

Citation Sources For Legal Scholarship: Ranking The Top 28 Law Faculties, John R. Beatty

Law Librarian Contributions to Books

Published in The Role of Citation in the Law: A Yale Law School Symposium, Michael Chiorazzi, ed.

This study examines the effects of the data source on citation metrics and faculty rankings by comparing three sources of legal scholarship citation data: Google Scholar, Westlaw, and HeinOnline. It compares six years of citations to works by all of the tenured and tenure-track members of the top twenty-eight faculties as determined by two recent legal citation studies. Rankings generated using the Leiter-Sisk method on the data from the three sources showed moderate to high correlation (0. 77 to 0. 96) to each …


A Modern Guide To Tourism Economics, Chapter 1: Introduction, Robertico Croes, Yang Yang Sep 2022

A Modern Guide To Tourism Economics, Chapter 1: Introduction, Robertico Croes, Yang Yang

Faculty Scholarship and Creative Works

This Modern Guide captures the evolution of foundational tenets, theories, frameworks and models that buttressed tourism economics into an evolving discipline, shining light on both new and old approaches. It systematically examines current and future trends and issues related to new economic perspectives, consolidating the notion of tourism economics as a discipline.


Evaluation Of The Control Of Water Sanitation And Hygiene Related Disease Through Community Hygiene Club Intervention In Rwanda, Amans Ntakarutimana, Elias Nyandwi, Nadine Rujeni, Chantal Marie Ingabire Dr, Kato Jonas Njunwa, Théoneste Ntakirutimana, Gaspard Rwanyiziri, Joseph Tuyishimire, Schaddrack Ngabonziza Sep 2022

Evaluation Of The Control Of Water Sanitation And Hygiene Related Disease Through Community Hygiene Club Intervention In Rwanda, Amans Ntakarutimana, Elias Nyandwi, Nadine Rujeni, Chantal Marie Ingabire Dr, Kato Jonas Njunwa, Théoneste Ntakirutimana, Gaspard Rwanyiziri, Joseph Tuyishimire, Schaddrack Ngabonziza

Journal of Social, Behavioral, and Health Sciences

This article consists of a review article reporting the results of previous evaluations of the control of water, sanitation, and hygiene (WASH) related disease through the Community Hygiene Club (CHC) intervention from 2010 to 2020. CHC constitutes the main intervention for the control of WASH-related disease in Rwanda and is implemented countrywide. The study objective was to evaluate if the CHC intervention significantly reduced the prevalence of WASH-related disease after 10 years of its implementation in Rwanda. The study utilized online existing policy documents, research reports, and experiences on the CHC intervention in Rwanda published between 2010 and 2020. We …


Reducing Property Taxes For Agriculture: Diffusion Of Use-Value Assessment Policy Across The United States, John E. Anderson, Seth H. Giertz, Shafiun N. Shimul Sep 2022

Reducing Property Taxes For Agriculture: Diffusion Of Use-Value Assessment Policy Across The United States, John E. Anderson, Seth H. Giertz, Shafiun N. Shimul

Department of Economics: Faculty Publications

We analyze the spread across the fifty states of use-value assessment (UVA) programs applied to agricultural and rural land for property tax purposes. Taxing land based on the value associated with its current use in agriculture rather than its full market value can confer substantial tax savings for landowners, affecting land use patterns. Using time-to-event models, we find that the secular trend toward urbanization across all fifty states was a driving force behind the spread of UVA policies. In particular, increasing secular trends in agricultural land values (associated with urbanization) provide a strong motivation for agriculture to pursue UVA, and …


Resource Acquisition And The Role Of Collection Development Policy In The Development Of Ghana Communication Technology University Library Collection, Benedicta Krampah Akoto Bitherman, Afua Frempong-Kore Sep 2022

Resource Acquisition And The Role Of Collection Development Policy In The Development Of Ghana Communication Technology University Library Collection, Benedicta Krampah Akoto Bitherman, Afua Frempong-Kore

Library Philosophy and Practice (e-journal)

The study was carried out to ascertain the significance of collection development policy in some public academic libraries in Ghana with Ghana Communication Technology University as the case study. The study adopted a case study design and used a qualitative method in its examinations. A self-designed interview schedule was used to solicit information from the staff library. The study participants included the head librarian, deputy librarian and four (4) assistant librarians. The face-to-face interview method was used as a data collection instrument for this study– content analysis was used to analyse the data. The findings indicated that the university library …


Black Trust In Us Legislatures, Ernest Dupree Iii, John R. Hibbing Sep 2022

Black Trust In Us Legislatures, Ernest Dupree Iii, John R. Hibbing

Department of Political Science: Faculty Publications

Trust is a key part of any political system. Given the very different experiences of Black people and White people in the United States, it is likely that the nature and contours of political trust varies widely from one racial group to the other. In this article, we take advantage of a specially commissioned 2018 survey to compare Black and White trust in American legislative institutions (Congress and the state legislatures). Thanks to an oversample, we also are able to zero in on variations across Black respondents, making it possible to identify the variables that push legislative trust up or …


Availability And Accessibility Of Health Information To Women In Rural Community, Elemere, Moro Local Government, Kwara State, Olamide Hammed Olaiya, Marcus Oladotun Aragbaye, Omolara Deborah Akintobi Sep 2022

Availability And Accessibility Of Health Information To Women In Rural Community, Elemere, Moro Local Government, Kwara State, Olamide Hammed Olaiya, Marcus Oladotun Aragbaye, Omolara Deborah Akintobi

Library Philosophy and Practice (e-journal)

This research work investigates the availability and accessibility of health information by rural women in Elemere communities of moro local government, Kwara state. Questionnaire and interviews are major instruments used for data collection which was done by examining relevant documents to obtain necessary information 10 set of questionnaire were administered to health workers and health information providers in which all the 10 questionnaires were retrieved. Interviews were conducted on forty (40) rural women. the study selects reconnaissance survey for its design. The data gotten from the study area was further analysed with the use of descriptive techniques such as frequency …


Borderplex Business Barometer, Volume 6, Number 9, Thomas M. Fullerton Jr., Steven L. Fullerton, Chia-Chun Chiang Sep 2022

Borderplex Business Barometer, Volume 6, Number 9, Thomas M. Fullerton Jr., Steven L. Fullerton, Chia-Chun Chiang

Border Region Modeling Project

No abstract provided.


Innovation Culture Assessment: An Exploratory Diagnosis Of A Taiwanese Manufacturing Company, Yong Keong Tay Sep 2022

Innovation Culture Assessment: An Exploratory Diagnosis Of A Taiwanese Manufacturing Company, Yong Keong Tay

Dissertations and Theses Collection (Open Access)

The purpose of this research study is to better understand how manufacturing firms in Asia are trying to make innovation work and the challenges they are facing in creating and capturing new value. Based on a real-life case study of a medium-sized OEM lock manufacturer in Taiwan (“3ST”), the study sheds light on key building blocks of a robust corporate innovation culture with focus on ‘Values’, ‘Behaviours’, ‘Climate’, ‘Resources’, ‘Processes’, and ‘Success’, using a valid and reliable diagnostic innovation culture framework developed by Rao & Weintraub (2013).

Besides the identification of critical gaps in 3ST’s innovation culture based on Rao …


A Study On The Impact Of Technological Innovation Attributes On Listing Success Rate And Post-Listing Performance, Yijun Xu Sep 2022

A Study On The Impact Of Technological Innovation Attributes On Listing Success Rate And Post-Listing Performance, Yijun Xu

Dissertations and Theses Collection (Open Access)

"Key and core technology" enterprises form the backbone of great powers. China’s STAR Market (technological innovation board) is committed to implementing strategies that will lead to technological innovation-driven sustainable development and strengthen the country by building a secure and independent industrial chain that can support the development of cutting-edge technology. From the outset, the STAR Market put forward clear requirements for "key and core technology" enterprises. The technological innovation attributes of the enterprises listed on the STAR Market are the most essential core characteristics, but a question arises as to how best to evaluate their technological innovation attributes. Are these …


The Impacts Of Problematic Social Media Use On Youths: Evaluation And Treatment Recommendations, Carianne Archer Sep 2022

The Impacts Of Problematic Social Media Use On Youths: Evaluation And Treatment Recommendations, Carianne Archer

Dissertations

Youths’ frequency and time spent on social media continues to increase over the years parallel to the growing concern of the status of the mental health of youth. This critical literature review project focuses on the impacts that social media use has on youth (ages 8 to 18 years) and what methods of evaluation and treatment are being used clinically, with recommendations provided to clinicians based on the available literature. The questions that guided this review included: What are the impacts of social media on the self-concept and interpersonal functioning of youths?; What clinical presentations are associated with youths who …


Emergence Of A Norm From Resistance: Using Simulation To Explore The Macro Implications Of Social Identity Theory, Khadijeh Salimi, Jesse T. Richman, Regina Karp, George P. Richardson, David Anderson Sep 2022

Emergence Of A Norm From Resistance: Using Simulation To Explore The Macro Implications Of Social Identity Theory, Khadijeh Salimi, Jesse T. Richman, Regina Karp, George P. Richardson, David Anderson

Political Science & Geography Faculty Publications

We usually hope that social norms discourage injustice. However, we are all witnesses to harmful norms enforced by governments, such as xenophobia, which need to be contested and changed. Previous studies have concluded that it is possible to change a harmful norm through contestation by powerless actors if suitable structural conditions exist. However, these structural conditions have not been sufficiently studied and, as such, are the focus of this paper. Our paper begins with a review of well-established micro-level theories of social identity theory (SIT), recast as a set of 42 discrete theoretical statements. These statements are then re-expressed in …


Inclusive And Anti-Racist Collecting At Unlv: Draft Report And Recommendations, Annette Day, Sarah R. Jones, Amy Tureen, Susan B. Wainscott, Amanda Melilli, Thomas Padilla, Aidy Weeks Sep 2022

Inclusive And Anti-Racist Collecting At Unlv: Draft Report And Recommendations, Annette Day, Sarah R. Jones, Amy Tureen, Susan B. Wainscott, Amanda Melilli, Thomas Padilla, Aidy Weeks

Library Faculty Research

The UNLV University Libraries recognizes that as both a direct and indirect result of colonialism and white supremacy the historical and contemporary scholarly publishing market atypically centers and prioritizes voices that are white, male, Christian, able-bodied, and heterosexual (Muka, 2018; Ray, 2018; Baffoe, Asimeng-Boahene, & Buster, 2014; and Buggs, Sims, & Kramer, 2020). In an attempt to redress this imbalance, the UNLV University Libraries is committed to collecting content by and about people and communities that have historically been excluded. This effort includes but is not limited to the intentional collection of materials about and by groups historically excluded by …


Context For Reproducibility And Replicability In Geospatial Unmanned Aircraft Systems, Cassandra Howe, Jason A. Tullis Sep 2022

Context For Reproducibility And Replicability In Geospatial Unmanned Aircraft Systems, Cassandra Howe, Jason A. Tullis

Geosciences Faculty Publications and Presentations

Multiple scientific disciplines face a so-called crisis of reproducibility and replicability (R&R) in which the validity of methodologies is questioned due to an inability to confirm experimental results. Trust in information technology (IT)-intensive workflows within geographic information science (GIScience), remote sensing, and photogrammetry depends on solutions to R&R challenges affecting multiple computationally driven disciplines. To date, there have only been very limited efforts to overcome R&R-related issues in remote sensing workflows in general, let alone those tied to unmanned aircraft systems (UAS) as a disruptive technology. This review identifies key barriers to, and suggests best practices for, R&R in geospatial …


Vaccine-Linked Chemotherapy With A Low Dose Of Benznidazole Plus A Bivalent Recombinant Protein Vaccine Prevents The Development Of Cardiac Fibrosis Caused By Trypanosoma Cruzi In Chronically-Infected Balb/C Mice, Victor Manuel Dzul-Huchim, Maria Jesus Ramirez-Sierra, Pedro Pablo Martinez-Vega, Miguel Enrique Rosado-Vallado, Victor Ermilo Arana-Argaez, Jaime Ortega-Lopez, Fabian Gusovsky, Eric Dumonteil, Julio Vladimir Cruz-Chan, Peter Hotez, María Elena Bottazzi, Liliana Estefania Villanueva-Lizama Sep 2022

Vaccine-Linked Chemotherapy With A Low Dose Of Benznidazole Plus A Bivalent Recombinant Protein Vaccine Prevents The Development Of Cardiac Fibrosis Caused By Trypanosoma Cruzi In Chronically-Infected Balb/C Mice, Victor Manuel Dzul-Huchim, Maria Jesus Ramirez-Sierra, Pedro Pablo Martinez-Vega, Miguel Enrique Rosado-Vallado, Victor Ermilo Arana-Argaez, Jaime Ortega-Lopez, Fabian Gusovsky, Eric Dumonteil, Julio Vladimir Cruz-Chan, Peter Hotez, María Elena Bottazzi, Liliana Estefania Villanueva-Lizama

Center for Medical Ethics and Health Policy Staff Publications

Background: Chagas disease (CD) is caused by Trypanosoma cruzi and affects 6-7 million people worldwide. Approximately 30% of chronic patients develop chronic chagasic cardiomyopathy (CCC) after decades. Benznidazole (BNZ), one of the first-line chemotherapy used for CD, induces toxicity and fails to halt the progression of CCC in chronic patients. The recombinant parasite-derived antigens, including Tc24, Tc24-C4, TSA-1, and TSA-1-C4 with Toll-like receptor 4 (TLR-4) agonist-adjuvants reduce cardiac parasite burdens, heart inflammation, and fibrosis, leading us to envision their use as immunotherapy together with BNZ. Given genetic immunization (DNA vaccines) encoding Tc24 and TSA-1 induce protective immunity in mice and …


Will Anti-Vaccine Activism In The Usa Reverse Global Goals?, Peter J Hotez Sep 2022

Will Anti-Vaccine Activism In The Usa Reverse Global Goals?, Peter J Hotez

Center for Medical Ethics and Health Policy Staff Publications

In the time of the COVID-19 pandemic, anti-vaccine activism in the USA accelerated, amplified and formed an alliance with political groups and even extremists. An organized, well-funded and empowered anti-science movement now threatens to spill over and threaten all childhood immunizations in the USA and globally.


An Ultra-Brief Screening Scale For Pediatric Obsessive-Compulsive Disorder: The Oci-Cv-5, Amitai Abramovitch, Jonathan S Abramowitz, Dean Mckay, Heining Cham, Kennedy S Anderson, Lara J Farrell, Daniel A Geller, Gregory L Hanna, Sharna Mathieu, Joseph F Mcguire, David R Rosenberg, S Evelyn Stewart, Eric A Storch, Sabine Wilhelm Sep 2022

An Ultra-Brief Screening Scale For Pediatric Obsessive-Compulsive Disorder: The Oci-Cv-5, Amitai Abramovitch, Jonathan S Abramowitz, Dean Mckay, Heining Cham, Kennedy S Anderson, Lara J Farrell, Daniel A Geller, Gregory L Hanna, Sharna Mathieu, Joseph F Mcguire, David R Rosenberg, S Evelyn Stewart, Eric A Storch, Sabine Wilhelm

Center for Medical Ethics and Health Policy Staff Publications

Background: Obsessive-compulsive disorder (OCD) is an often disabling and chronic condition that is normally assessed using diagnostic interviews or lengthy self-report questionnaires. This makes routine screening in general health settings impractical, and as a result OCD is often under-(or mis-)recognized. The present study reports on the development of an ultra-brief version of the Obsessive-Compulsive Inventory-Child Version (OCI-CV) which may be administered routinely as a screener for pediatric OCD.

Method: A total of 489 youth diagnosed with OCD, 259 non-clinical controls, and 299 youth with other disorders completed the OCI-CV and other indices of psychopathology. Using item analyses, we extracted five …


High Prevalence Of Osteopathy In Chronic Pancreatitis: A Cross-Sectional Analysis From The Proceed Study, Phil A Hart, Dhiraj Yadav, Liang Li, Savi Appana, William Fisher, Evan Fogel, Chris E Forsmark, Walter G Park, Stephen Pandol, Mark D Topazian, Stephen K Van Den Eden, Santhi Swaroop Vege, David Bradley, Jose Serrano, Darwin L Conwell Sep 2022

High Prevalence Of Osteopathy In Chronic Pancreatitis: A Cross-Sectional Analysis From The Proceed Study, Phil A Hart, Dhiraj Yadav, Liang Li, Savi Appana, William Fisher, Evan Fogel, Chris E Forsmark, Walter G Park, Stephen Pandol, Mark D Topazian, Stephen K Van Den Eden, Santhi Swaroop Vege, David Bradley, Jose Serrano, Darwin L Conwell

Center for Medical Ethics and Health Policy Staff Publications

Background & aims: Chronic pancreatitis (CP) is associated with osteopathy (osteoporosis or osteopenia). However, existing literature is mostly limited to retrospective or administrative studies that have not clearly defined the prevalence and risk factors. Our aim was to identify patient- and disease-related associations with osteopathy in a prospective cohort study of CP.

Methods: We studied 282 subjects with definitive CP enrolled in the PROCEED study who had a baseline dual-energy X-ray absorptiometry (DXA) scan. Osteopenia and osteoporosis were defined using the lowest T-scores. Clinical data were collected using standardized case report forms. Comparisons were performed with a multivariate logistic regression …


Rates Of Laboratory Adverse Events By Course In Paediatric Leukaemia Ascertained With Automated Electronic Health Record Extraction: A Retrospective Cohort Study From The Children’S Oncology Group, Tamara P Miller, Kelly D Getz, Yimei Li, Biniyam G Demissei, Peter C Adamson, Todd A Alonzo, Evanette Burrows, Lusha Cao, Sharon M Castellino, Marla H Daves, Brian T Fisher, Robert Gerbing, Robert W Grundmeier, Edward M Krause, Judy Lee, Philip J Lupo, Karen R Rabin, Mark Ramos, Michael E Scheurer, Jennifer J Wilkes, Lena E Winestone, Douglas S Hawkins, M Monica Gramatges, Richard Aplenc Sep 2022

Rates Of Laboratory Adverse Events By Course In Paediatric Leukaemia Ascertained With Automated Electronic Health Record Extraction: A Retrospective Cohort Study From The Children’S Oncology Group, Tamara P Miller, Kelly D Getz, Yimei Li, Biniyam G Demissei, Peter C Adamson, Todd A Alonzo, Evanette Burrows, Lusha Cao, Sharon M Castellino, Marla H Daves, Brian T Fisher, Robert Gerbing, Robert W Grundmeier, Edward M Krause, Judy Lee, Philip J Lupo, Karen R Rabin, Mark Ramos, Michael E Scheurer, Jennifer J Wilkes, Lena E Winestone, Douglas S Hawkins, M Monica Gramatges, Richard Aplenc

Center for Medical Ethics and Health Policy Staff Publications

Background: Adverse events are often misreported in clinical trials, leading to an incomplete understanding of toxicities. We aimed to test automated laboratory adverse event ascertainment and grading (via the ExtractEHR automated package) to assess its scalability and define adverse event rates for children with acute myeloid leukaemia and acute lymphoblastic leukaemia.

Methods: For this retrospective cohort study from the Children's Oncology Group (COG), we included patients aged 0-22 years treated for acute myeloid leukaemia or acute lymphoblastic leukaemia at Children's Healthcare of Atlanta (Atlanta, GA, USA) from Jan 1, 2010, to Nov 1, 2018, at the Children's Hospital of Philadelphia …


Change During Cognitive And Exposure Phases Of Cognitive-Behavioral Therapy For Autistic Youth With Anxiety Disorders, Andrew G Guzick, Sophie C Schneider, Philip C Kendall, Jeffrey J Wood, Connor M Kerns, Brent J Small, Ye Eun Park, Sandra L Cepeda, Eric A Storch Sep 2022

Change During Cognitive And Exposure Phases Of Cognitive-Behavioral Therapy For Autistic Youth With Anxiety Disorders, Andrew G Guzick, Sophie C Schneider, Philip C Kendall, Jeffrey J Wood, Connor M Kerns, Brent J Small, Ye Eun Park, Sandra L Cepeda, Eric A Storch

Center for Medical Ethics and Health Policy Staff Publications

Objective: To evaluate improvement during the (a) cognitive and (b) exposure therapy phases of cognitive-behavioral therapy (CBT) for autistic youth with anxiety disorders.

Method: Participants were 148 autistic youth (aged 7-13; 77% male; 64% White) with clinically significant anxiety who were randomized to standard or adapted CBT. Clinician-rated anxiety severity was recorded at each appointment. Trajectories of change during (a) the cognitive phase and (b) the exposure phase of treatment were analyzed using piecewise multilevel modeling.

Results: Compared to the psychoeducation and cognitive therapy phases, the exposure phase corresponded with significantly more rapid symptom reduction, b = -.11, 95% CI …