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Articles 77731 - 77760 of 658705

Full-Text Articles in Social and Behavioral Sciences

Digital Nudging: Potentional And Pitfalls, Avishalom Tor Oct 2022

Digital Nudging: Potentional And Pitfalls, Avishalom Tor

Journal Articles

From the Article

Digital nudges — that is, significantly behavioral interventions that use software and its user-interface design elements — are an increasingly pervasive feature of online environments that can shape people’s behavior both online (e.g. changing website cookie settings) and offline (e.g. taking a flu vaccine due to a text message reminder). While sharing many characteristics of offline behavioral interventions, digital nudges merit specific attention and analysis due to their growing ubiquity and potential potency, the opacity of their technological and behavioral mechanisms, and the central role of private actors in their implementation.


Commonality In Credit Spread Changes: Dealer Inventory And Intermediary Distress, Zhiguo He, Paymon Khorrami, Zhaogang Song Oct 2022

Commonality In Credit Spread Changes: Dealer Inventory And Intermediary Distress, Zhiguo He, Paymon Khorrami, Zhaogang Song

Research Collection Lee Kong Chian School Of Business

Two intermediary-based factors—a corporate bond dealer inventory measure and a broad intermediary distress measure—explain more than 40% of the puzzling common variation in credit spread changes beyond canonical structural factors. A simple intermediary-based model with partial market segmentation accounts for intermediary factors’ explanatory power and delivers three further implications with empirical support. First, whereas bond sorts on risk-related variables produce monotonic loading patterns on intermediary factors, non-risk-related sorts produce no pattern. Second, dealer inventory comoves with corporate-credit assets only, whereas intermediary distress comoves with both corporate-credit and non-corporate-credit assets. Third, dealers’ inventory responds to (instrumented) bond sales by institutional investors.


Made In Singapore, Pao-Li Chang, Tran Bao Phuong Nguyen Oct 2022

Made In Singapore, Pao-Li Chang, Tran Bao Phuong Nguyen

Research Collection School Of Economics

In this paper, we characterize the position of Singapore in global value chains and identify Singapore’s key upstream and downstream trade partners. We trace how the position of Singapore in global value chains has changed in the past two decades: whether it has moved upstream or downstream, how involved it is in global value chains, how its trend compares with the other major Asian exporters (China, Japan, Korea, Taiwan and Hong Kong), and which key sectors of Singapore play a major role in these global trade networks.


Longitudinal Changes In Wellbeing Amongst Breastfeeding Women In Australia And New Zealand During The Covid-19 Pandemic, Vanessa S. Sakalidis, Alethea Rea, Sharon L. Perrella, Jacki Mceachran, Grace Collis, Jennifer Miraudo, Stuart A. Prosser, Lisa Y. Gibson, Desiree Silva, Donna T. Geddes Oct 2022

Longitudinal Changes In Wellbeing Amongst Breastfeeding Women In Australia And New Zealand During The Covid-19 Pandemic, Vanessa S. Sakalidis, Alethea Rea, Sharon L. Perrella, Jacki Mceachran, Grace Collis, Jennifer Miraudo, Stuart A. Prosser, Lisa Y. Gibson, Desiree Silva, Donna T. Geddes

Research outputs 2022 to 2026

The COVID-19 pandemic has impacted new mothers’ wellbeing and breastfeeding experience. Women have experienced changes in birth and postnatal care and restricted access to their support network. It is unclear how these impacts may have changed over time with shifting rates of infection and policies restricting movement and access to services in Australia and New Zealand. This study investigated the longitudinal effect of the COVID-19 pandemic on breastfeeding and maternal wellbeing in Australia and New Zealand. Mothers (n = 246) completed an online survey every 4 weeks for 6 months that examined feeding methods, maternal mental wellbeing, worries, challenges, and …


Clinical Management Of Financial Toxicity - Identifying Opportunities Through Experiential Insights Of Cancer Survivors, Caregivers, And Social Workers, Christopher J. Longo, Louisa G. Gordon, Rebecca L. Nund, Nicolas H. Hart, Laisa Teleni, Carla Thamm, Olivia Hollingdrake, Fiona Crawford-Williams, Bogda Koczwara, Tamara Ownsworth, Stephen Born, Sue Schoonbeek, Leanne Stone, Christie Barrett, Raymond J. Chan Oct 2022

Clinical Management Of Financial Toxicity - Identifying Opportunities Through Experiential Insights Of Cancer Survivors, Caregivers, And Social Workers, Christopher J. Longo, Louisa G. Gordon, Rebecca L. Nund, Nicolas H. Hart, Laisa Teleni, Carla Thamm, Olivia Hollingdrake, Fiona Crawford-Williams, Bogda Koczwara, Tamara Ownsworth, Stephen Born, Sue Schoonbeek, Leanne Stone, Christie Barrett, Raymond J. Chan

Research outputs 2022 to 2026

Perspectives of cancer survivors, caregivers, and social workers as key stakeholders on the clinical management of financial toxicity (FT) are critical to identify opportunities for better FT management. Semi-structured interviews (cancer survivors, caregivers) and a focus group (social workers) were undertaken using purposive sampling at a quaternary public hospital in Australia. People with any cancer diagnosis attending the hospital were eligible. Data were analysed using inductive-deductive content analysis techniques. Twenty-two stakeholders (n = 10 cancer survivors of mixed-cancer types, n = 5 caregivers, and n = 7 social workers) participated. Key findings included: (i) genuine concern for FT of cancer …


The Alphabet Soup In Reporting And Measuring Esg, Hao Liang, Kam Chee Chan Oct 2022

The Alphabet Soup In Reporting And Measuring Esg, Hao Liang, Kam Chee Chan

Research Collection Lee Kong Chian School Of Business

Harmonising frameworks with the Impact-Weighted Accounts Framework.


Price Dynamics Of Swedish Pharmaceuticals, Aljoscha Janssen Oct 2022

Price Dynamics Of Swedish Pharmaceuticals, Aljoscha Janssen

Research Collection School Of Economics

This paper investigates price patterns of off-patent pharmaceuticals in Sweden. I show that price dynamics are dependent on the number of competitors in the market. The price patterns follow predictions from a model of dynamic price competition in which the demand for pharmaceuticals incorporates the known biases of consumers: habit persistence and brand preferences. Using the regulated market of Swedish pharmaceuticals, I show that price dynamics may help in identifying possible tacit collusion by manufacturers in markets where consumers experience behavioral frictions.


Good Names Beget Favors: The Impact Of Country Image On Trade Flows And Welfare, Pao-Li Chang, Tomoki Fujii, Wei Jin Oct 2022

Good Names Beget Favors: The Impact Of Country Image On Trade Flows And Welfare, Pao-Li Chang, Tomoki Fujii, Wei Jin

Research Collection School Of Economics

This paper estimates the effects of time-varying consumer preference bias on trade flows and welfare. We use a unique data set from the BBC World Service Poll, which surveys (annually during 2005–2017 with some gaps) the populations of a wide array of countries on their views of whether an evaluated country is having a mainly positive or negative influence in the world. We identify the effects on consumer preference parameters due to shifts in these country image perceptions and quantify their general equilibrium effects on bilateral exports and welfare (each time for an evaluated exporting country, holding the exporting country’s …


Disentangling The Effects Of Gatt/Wto On Variable And Fixed Trade Costs: Trade Status, Trade Margins, And Export Sales Distribution, Pao-Li Chang, Renjing Chen, Wei Jin Oct 2022

Disentangling The Effects Of Gatt/Wto On Variable And Fixed Trade Costs: Trade Status, Trade Margins, And Export Sales Distribution, Pao-Li Chang, Renjing Chen, Wei Jin

Research Collection School Of Economics

In this paper, we develop an estimation procedure to identify the partial (direct) effects of the GATT/WTO membership on the variable and the fixed trade cost, re-spectively. This extends the techniques of Anderson and Van Wincoop (2003) on the structural relationship of multilateral resistance terms and of Helpman, Melitz and Rubinstein (2008) on the structural modelling of trade incidence. We then develop a general equilibrium framework (that allows the presence of zero trade) to simulate the impact of variable, fixed, and total trade cost changes on the firm-level trade structure (including bilateral export productivity cutoff, weighted/unweighted extensive margin of export, …


Robust Testing For Explosive Behavior With Strongly Dependent Errors, Yiu Lim Lui, Peter C. B. Phillips, Jun Yu Oct 2022

Robust Testing For Explosive Behavior With Strongly Dependent Errors, Yiu Lim Lui, Peter C. B. Phillips, Jun Yu

Research Collection School Of Economics

A heteroskedasticity-autocorrelation robust (HAR) test statistic is proposed to test for the presence of explosive roots in financial or real asset prices when the equation errors are strongly dependent. Limit theory for the test statistic is developed and extended to heteroskedastic models. The new test has stable size properties unlike conventional test statistics that typically lead to size distortion and inconsistency in the presence of strongly dependent equation errors. The new procedure can be used to consistently time-stamp the origination and termination of an explosive episode under similar conditions of long memory errors. Simulations are conducted to assess the finite …


On The Optimal Forecast With The Fractional Brownian Motion, Xiaohu Wang, Chen Zhang, Jun Yu Oct 2022

On The Optimal Forecast With The Fractional Brownian Motion, Xiaohu Wang, Chen Zhang, Jun Yu

Research Collection School Of Economics

This paper examines the performance of alternative forecasting formulae with the fractional Brownian motion based on a discrete and finite sample. One formula gives the optimal forecast when a continuous record over the infinite past is available. Another formula gives the optimal forecast when a continuous record over the finite past is available. Alternative discretiza-tion schemes are proposed to approximate these formulae. These alternative discretization schemes are then compared with the conditional expectation of the target variable on the vector of the discrete and finite sample. It is shown that the conditional expectation delivers more accurate forecasts than the discretization-based …


Low-Rank Panel Quantile Regression: Estimation And Inference, Yiren Wang, Yichong Zhang, Yichong Zhang Oct 2022

Low-Rank Panel Quantile Regression: Estimation And Inference, Yiren Wang, Yichong Zhang, Yichong Zhang

Research Collection School Of Economics

In this paper, we propose a class of low-rank panel quantile regression models which allow for unobserved slope heterogeneity over both individuals and time. We estimate the heterogeneous intercept and slope matrices via nuclear norm regularization followed by sample splitting, row- and column-wise quantile regressions and debiasing. We show that the estimators of the factors and factor loadings associated with the intercept and slope matrices are asymptotically normally distributed. In addition, we develop two specification tests: one for the null hypothesis that the slope coefficient is a constant over time and/or individuals under the case that true rank of slope …


Incentivizing Innovation: Promoting Technical Competency To Win Future Wars., James E. Bevins Oct 2022

Incentivizing Innovation: Promoting Technical Competency To Win Future Wars., James E. Bevins

Faculty Publications

Despite numerous studies and initiatives, most current Air Force efforts to add science and technology talent have been insufficient. This begs the question: How does the Air Force incentivize and promote the necessary technical competence required to win future competition, conflicts, and wars? Several key initiatives, grounded in behavioral economics, can incentivize innovation and pursue science and technology expertise. Developed in the context of peer adversaries’ actions; global trends in technology, competition, and conflict; and the global competition for science and technology talent, these recommendations have the potential to reform institutional culture and unleash the creativity and talent of the …


A Century Of Drought In HawaiʻI: Geospatial Analysis And Synthesis Across Hydrological, Ecological, And Socioeconomic Scales, Abby G. Frazier, Christian P. Giardina, Thomas W. Giambelluca, Laura Brewington, Yi Leng Chen, Pao Shin Chu, Lucas Berio Fortini, Danielle Hall, David A. Helweg, Victoria W. Keener, Ryan J. Longman, Matthew P. Lucas, Alan Mair, Delwyn S. Oki, Julian J. Reyes, Stephanie G. Yelenik, Clay Trauernicht Oct 2022

A Century Of Drought In HawaiʻI: Geospatial Analysis And Synthesis Across Hydrological, Ecological, And Socioeconomic Scales, Abby G. Frazier, Christian P. Giardina, Thomas W. Giambelluca, Laura Brewington, Yi Leng Chen, Pao Shin Chu, Lucas Berio Fortini, Danielle Hall, David A. Helweg, Victoria W. Keener, Ryan J. Longman, Matthew P. Lucas, Alan Mair, Delwyn S. Oki, Julian J. Reyes, Stephanie G. Yelenik, Clay Trauernicht

Geography

Drought is a prominent feature of Hawaiʻi’s climate. However, it has been over 30 years since the last comprehensive meteorological drought analysis, and recent drying trends have emphasized the need to better understand drought dynamics and multi-sector effects in Hawaiʻi. Here, we provide a comprehensive synthesis of past drought effects in Hawaiʻi that we integrate with geospatial analysis of drought characteristics using a newly developed 100-year (1920–2019) gridded Standardized Precipitation Index (SPI) dataset. The synthesis examines past droughts classified into five categories: Meteorological, agricultural, hydrological, ecological, and socioeconomic drought. Results show that drought duration and magnitude have increased significantly, consistent …


Competency-Based Social Work Education: 25 Years Of Innovation & Leadership, Zoë Breen Wood, Marjorie N. Edguer, David L. Hussey, Mark Chupp, Grover C. Gilmore, Paul M. Kubek Oct 2022

Competency-Based Social Work Education: 25 Years Of Innovation & Leadership, Zoë Breen Wood, Marjorie N. Edguer, David L. Hussey, Mark Chupp, Grover C. Gilmore, Paul M. Kubek

Faculty Scholarship

The white paper chronicles the 25-year history of one graduate school of social work’s efforts in competency-based curriculum innovation. The authors argue that curriculum change is organizational change and share their experiences with a variety of curriculum assessment, design, and delivery efforts. Beginning with the development of the first social work competencies (labeled Abilities), pioneering efforts in assessment and holistic curricular design and delivery are reviewed. A new, one-semester, social work generalist curriculum is introduced. Emphasis is placed on the importance of developing a competency-based curriculum that is integrated both horizontally and vertically and that engages the social work student …


Incidence And 5-Year Survival Of Children And Adolescents With Hepatoblastoma In The United States, Justin A Kahla, David A Siegel, Shifan Dai, Philip J Lupo, Jennifer H Foster, Michael E Scheurer, Andras A Heczey Oct 2022

Incidence And 5-Year Survival Of Children And Adolescents With Hepatoblastoma In The United States, Justin A Kahla, David A Siegel, Shifan Dai, Philip J Lupo, Jennifer H Foster, Michael E Scheurer, Andras A Heczey

Center for Medical Ethics and Health Policy Staff Publications

Objective: Hepatoblastoma (HB) is the most common pediatric primary malignant liver tumor, its incidence has been increasing worldwide, but recent changes in incidence and outcomes with high population coverage are not well characterized.

Methods: We defined the incidence of HB diagnosed during 2003-2017 from United States Cancer Statistics (USCS) database, and survival during 2001-2016 from the National Program of Cancer Registries (NPCR). Data were stratified by sex, race/ethnicity, age, tumor stage, county population, and diagnosis year. Incidence trends were assessed by calculating average annual percent change (AAPC) using Joinpoint regression. Differences in overall 5-year survival were estimated using Cox regression …


Longitudinal Investigation Of Suicidal Ideation And Associated Factors During Pediatric Acute Lymphoblastic Leukemia Chemotherapy, Kimberly P Raghubar, Tiffany Chambers, Ryan M Hill, Olga Taylor, Marilyn Hockenberry, M Casey Hooke, Pauline Mitby, Ida Ki Moore, Austin L Brown, Michael E Scheurer Oct 2022

Longitudinal Investigation Of Suicidal Ideation And Associated Factors During Pediatric Acute Lymphoblastic Leukemia Chemotherapy, Kimberly P Raghubar, Tiffany Chambers, Ryan M Hill, Olga Taylor, Marilyn Hockenberry, M Casey Hooke, Pauline Mitby, Ida Ki Moore, Austin L Brown, Michael E Scheurer

Center for Medical Ethics and Health Policy Staff Publications

Objective: This study describes the prevalence of suicidal ideation (SI) during acute lymphoblastic leukemia (ALL) therapy and investigates the influence of clinical factors and physical symptoms on SI.

Methods: The Children's Depressive Inventory (CDI-2) was administered to ALL patients (diagnosed 2012-2017) at start of consolidation, delayed intensification (DI), maintenance cycle 1 (MC1), and maintenance cycle 2 (MC2) in a multi-site study. SI was present if patients endorsed the item "I want to kill myself." Logistic regression models evaluated associations between SI and sociodemographic factors; depressive symptoms; and below average, average, and above average symptom clusters identified using latent class analysis …


Accounting For Toponyms With Multiple Classifiers In Colonial Valley Zapotec, Jasper E. Nash , '23 Oct 2022

Accounting For Toponyms With Multiple Classifiers In Colonial Valley Zapotec, Jasper E. Nash , '23

Senior Theses, Projects, and Awards

Toponyms are place names which have certain common linguistic properties across languages. Toponyms are typically formed by the combination of descriptive morphemes and noun classifiers (Ursini 2017). Southern Zapotec (SZ) languages are primarily spoken in the Southern Sierra Madre region of Oaxaca, Mexico. Southern Zapotec toponyms appear to have similar structures compared to those in the four languages analyzed by Ursini (2017), with spatial classifiers and descriptive morphemes merging to create a phrase which carries spatial features. Beam de Azcona (2012) categorizes Southern Zapotec toponyms according to whether there are no classifiers, one classifier, or multiple classifiers, as well as …


Viable Verbs And Adjectives For Mandarin Reduplication, Carrie Zhang , '23 Oct 2022

Viable Verbs And Adjectives For Mandarin Reduplication, Carrie Zhang , '23

Senior Theses, Projects, and Awards

In Chen Wang’s 2021 paper, the verb mingbai is used an example to prove his claim that for an AB word that could “be used potentially as either a verb or an adjective, its ABAB form tends to be verbal while its AABB form tends to be adjectival,” a claim that is also substantiated in Huang et. al (2009). As far as mingbai goes, this trend appears to be true, but does it apply to adjectives such as xuxin as well? This brief paper tests whether the claim about Chinese reduplication patterns holds true for other AB phrases, and looks …


Redefining Safety: Latinx Migrant Perspectives On School Safety In Rural Pennsylvania High Schools, Elizabeth Garcia , '23 Oct 2022

Redefining Safety: Latinx Migrant Perspectives On School Safety In Rural Pennsylvania High Schools, Elizabeth Garcia , '23

Senior Theses, Projects, and Awards

Redefining Safety: Latinx Migrant Perspectives on School Safety in Rural Pennsylvania. High Schools aims to answer the research question: What does a safe educational space look like for rurally based high school students from immigrant families? This thesis draws on my lived experiences growing up in a mixed-status immigrant family in rural, PA. Drawing from anthropological and interdisciplinary research that explores how marginalized communities experience and navigate systemic violence, this thesis explores themes in the Latinx immigrant community such as a contradictory sense of hyper surveillance and invisibility. Inspired by abolitionist and geographer Ruth Wilson Gilmore’s research, I focus on …


Looking Beyond The 'Middle Class' For Other Chinas, Qian Forrest Zhang Oct 2022

Looking Beyond The 'Middle Class' For Other Chinas, Qian Forrest Zhang

Research Collection School of Social Sciences

There are high hopes for China’s middle class. Thanks to their rising disposable income, this group of Chinese is expected to unleash a consumer revolution in the domestic market. However, I argue that the ‘middle class’ as a concept provides at best a partial understanding of the Chinese consumer population; at worst, it can even provide a misleading perspective that brings us to erroneous conclusions about its profile and size. Instead, I propose the notion of ‘three Chinas’ as an alternative way to make sense of China’s consumers. ‘First China’ comprises residents in medium and large-sized cities, ‘Second China’ consists …


Structured Reflection Increases Intentions To Reduce Other People’S Health Risks During Covid-19, Jairo Ramos, Marrissa D. Grant, Stephan Dickert, Kimin Eom, Alex Flores, Gabriela M. Jiga-Boy, Tehila Kogut, Marcus Mayorga, Eric J. Pedersen, Beatriz Pereira, Enrico Rubaltelli, K Sherman David, Paul Slovic, Västjäll. Daniel, Leaf Van Boven Oct 2022

Structured Reflection Increases Intentions To Reduce Other People’S Health Risks During Covid-19, Jairo Ramos, Marrissa D. Grant, Stephan Dickert, Kimin Eom, Alex Flores, Gabriela M. Jiga-Boy, Tehila Kogut, Marcus Mayorga, Eric J. Pedersen, Beatriz Pereira, Enrico Rubaltelli, K Sherman David, Paul Slovic, Västjäll. Daniel, Leaf Van Boven

Research Collection School of Social Sciences

People believe they should consider how their behavior might negatively impact other people, Yet their behavior often increases others’ health risks. This creates challenges for managing public health crises like the COVID-19 pandemic. We examined a procedure wherein people reflect on their personal criteria regarding how their behavior impacts others’ health risks. We expected structured reflection to increase people's intentions and decisions to reduce others’ health risks. Structured reflection increases attention to others’ health risks and the correspondence between people's personal criteria and behavioral intentions. In four experiments during COVID-19, people (N = 12,995) reported their personal criteria about how …


Outdoor Thermal Comfort Research In Transient Conditions: A Narrative Literature Review, Yuliya Dzyuban, Graces N. Y. Ching, Sin Kang Yik, Adrian J. Tan, Shreya Banerjee, Peter Jay Crank, Winston T. L. Chow Oct 2022

Outdoor Thermal Comfort Research In Transient Conditions: A Narrative Literature Review, Yuliya Dzyuban, Graces N. Y. Ching, Sin Kang Yik, Adrian J. Tan, Shreya Banerjee, Peter Jay Crank, Winston T. L. Chow

Research Collection College of Integrative Studies

In recent years, urban planners and designers are paying greater attention to Outdoor Thermal Comfort (OTC) studies due to the imminent threat of the Urban Heat Island and climate change on human health. Historically, indoor thermal comfort research assumed steady-state conditions, centralizing on the concept of thermal neutrality to determine optimal environmental parameters. Such research pivoted to investigating how non-steady-state, transient environmental conditions influence comfort. Recent studies underscore the usefulness of positive alliesthesia in providing a productive framework for OTC evaluation. In this article we first clarify the concepts related to thermal comfort-related terms, scales, and models in the literature. …


Analysing Impacts Of Urban Morphological Variables And Density On Outdoor Microclimate For Tropical Cities: A Review And A Framework Proposal For Future Research Directions, Shreya Banerjee, Ngai Yan Ching, Sin Kang Yik, Yuliya Dzyuban, Peter Jay Crank, Xin Yi Pek, Winston T. L. Chow Oct 2022

Analysing Impacts Of Urban Morphological Variables And Density On Outdoor Microclimate For Tropical Cities: A Review And A Framework Proposal For Future Research Directions, Shreya Banerjee, Ngai Yan Ching, Sin Kang Yik, Yuliya Dzyuban, Peter Jay Crank, Xin Yi Pek, Winston T. L. Chow

Research Collection College of Integrative Studies

Modifying urban morphology, defined as mass, density, and orientation of building stock in cities, are well-known heat mitigation strategies addressing urban heat islands (UHI) at various scales and consequent thermal discomfort. However, varying morphological aspects may have divergent effects on Outdoor Thermal Comfort (OTC) in cities. Unlike UHI, which is derived from urban-rural temperature differences, OTC can be quantified by thermal comfort indices considering the objective assessment of microclimatic variables including air temperature (Ta), relative humidity (RH), mean radiant temperature (TMRT), and wind speed (Va), as well as a subjective assessment of individual perception. In Singapore and other tropical cities, …


Developing Climate Resilient Cities, Winston T. L. Chow Oct 2022

Developing Climate Resilient Cities, Winston T. L. Chow

Research Collection College of Integrative Studies

We need to be quicker.


Psychiatric Polygenic Risk Scores: Child And Adolescent Psychiatrists’ Knowledge, Attitudes, And Experiences, Stacey Pereira, Katrina A Muñoz, Brent J Small, Takahiro Soda, Laura N Torgerson, Clarissa E Sanchez, Jehannine Austin, Eric A Storch, Gabriel Lázaro-Muñoz Oct 2022

Psychiatric Polygenic Risk Scores: Child And Adolescent Psychiatrists’ Knowledge, Attitudes, And Experiences, Stacey Pereira, Katrina A Muñoz, Brent J Small, Takahiro Soda, Laura N Torgerson, Clarissa E Sanchez, Jehannine Austin, Eric A Storch, Gabriel Lázaro-Muñoz

Center for Medical Ethics and Health Policy Staff Publications

Psychiatric polygenic risk scores (PRS) have potential utility in psychiatric care and prevention, but there are concerns about their implementation. We surveyed 960 US-based practicing child and adolescent psychiatrists' (CAP) about their experiences, perspectives, and potential uses of psychiatric PRS. While 23% of CAP reported that they had never heard of PRS, 10 % of respondents have had a patient/family bring PRS to them and 4% have generated PRS for patients. Though 25% stated they would request PRS if a patient/caregiver asked, 35% indicated that nothing would prompt them to request PRS. Most respondents (54%) believed psychiatric PRS are currently …


The Development And Initial Validation Of The Promis®+Hf-27 And Promis+Hf-10 Profiles, Faraz S Ahmad, Kathryn L Jackson, Susan E Yount, Nan E Rothrock, Michael A Kallen, Leilani Lacson, Karl Y Bilimoria, Abel N Kho, Raja Kannan Mutharasan, Peter A Mccullough, Jeffrey Bruckel, Savitri Fedson, Stephen E Kimmel, David T Eton, Kathleen L Grady, Clyde W Yancy, David Cella Oct 2022

The Development And Initial Validation Of The Promis®+Hf-27 And Promis+Hf-10 Profiles, Faraz S Ahmad, Kathryn L Jackson, Susan E Yount, Nan E Rothrock, Michael A Kallen, Leilani Lacson, Karl Y Bilimoria, Abel N Kho, Raja Kannan Mutharasan, Peter A Mccullough, Jeffrey Bruckel, Savitri Fedson, Stephen E Kimmel, David T Eton, Kathleen L Grady, Clyde W Yancy, David Cella

Center for Medical Ethics and Health Policy Staff Publications

Aims: Heart failure (HF) is a common and morbid condition impacting multiple health domains. We previously reported the development of the PROMIS®-Plus-HF (PROMIS+HF) profile measure, including universal and HF-specific items. To facilitate use, we developed shorter, PROMIS+HF profiles intended for research and clinical use.

Methods and results: Candidate items were selected based on psychometric properties and symptom range coverage. HF clinicians (n = 43) rated item importance and clinical actionability. Based on these results, we developed the PROMIS+HF-27 and PROMIS+HF-10 profiles with summary scores (0-100) for overall, physical, mental, and social health. In a cross-sectional sample (n = 600), we …


T1 Signal Intensity Ratio Of The Pancreas As An Imaging Biomarker For The Staging Of Chronic Pancreatitis, Temel Tirkes, Anil K Dasyam, Zarine K Shah, Evan L Fogel, Santhi Swaroop Vege, Liang Li, Shuang Li, Stephanie T Chang, Carlos A Farinas, Joseph R Grajo, Kareem Mawad, Naoki Takahashi, Sudhakar K Venkatesh, Ashley Wachsman, William E Fisher, Christopher E Forsmark, Phil A Hart, Stephen J Pandol, Walter G Park, Stephen K Van Den Eeden, Yunlong Yang, Mark Topazian, Dana K Andersen, Jose Serrano, Darwin L Conwell, Dhiraj Yadav, Consortium For The Study Of Chronic Pancreatitis, Diabetes, Pancreatic Cancer (Cpdpc) Oct 2022

T1 Signal Intensity Ratio Of The Pancreas As An Imaging Biomarker For The Staging Of Chronic Pancreatitis, Temel Tirkes, Anil K Dasyam, Zarine K Shah, Evan L Fogel, Santhi Swaroop Vege, Liang Li, Shuang Li, Stephanie T Chang, Carlos A Farinas, Joseph R Grajo, Kareem Mawad, Naoki Takahashi, Sudhakar K Venkatesh, Ashley Wachsman, William E Fisher, Christopher E Forsmark, Phil A Hart, Stephen J Pandol, Walter G Park, Stephen K Van Den Eeden, Yunlong Yang, Mark Topazian, Dana K Andersen, Jose Serrano, Darwin L Conwell, Dhiraj Yadav, Consortium For The Study Of Chronic Pancreatitis, Diabetes, Pancreatic Cancer (Cpdpc)

Center for Medical Ethics and Health Policy Staff Publications

Purpose: Our purpose was to validate the T1 SIR (T1 score) as an imaging biomarker for the staging of CP in a large, multi-institutional, prospective study.

Methods: The prospective study population included 820 participants enrolled in the PROCEED study from nine clinical centers between June 2017 and December 2021. A radiologist at each institution used a standardized method to measure the T1 signal intensity of the pancreas and the reference organs (spleen, paraspinal muscle, liver), which was used to derive respective T1 scores. Participants were stratified according to the seven mechanistic stages of chronic pancreatitis (MSCP 0-6) based on their …


Residence In A Latinx Enclave And End-Induction Minimal Residual Disease Positivity Among Children With Acute Lymphoblastic Leukemia, Joshua P Muñiz, John P Woodhouse, Amy E Hughes, Sandi L Pruitt, Karen R Rabin, Michael E Scheurer, Philip J Lupo, Jeremy M Schraw Oct 2022

Residence In A Latinx Enclave And End-Induction Minimal Residual Disease Positivity Among Children With Acute Lymphoblastic Leukemia, Joshua P Muñiz, John P Woodhouse, Amy E Hughes, Sandi L Pruitt, Karen R Rabin, Michael E Scheurer, Philip J Lupo, Jeremy M Schraw

Center for Medical Ethics and Health Policy Staff Publications

Racial and ethnic inequities in survival persist for children with acute lymphoblastic leukemia (ALL). In the US, there are strong associations between SES, race/ethnicity, and place of residence. This is evidenced by ethnic enclaves: neighborhoods with high concentrations of ethnic residents, immigrants, and language isolation. The Latinx enclave index (LEI) can be used to investigate how residence in a Latinx enclave is associated with health outcomes. We studied the association between LEI score and minimal residual disease (MRD) in 142 pediatric ALL patients treated at Texas Children's Hospital. LEI score was associated with end-induction MRD positivity (OR per unit increase …


Characteristics Of Graft-Versus-Host Disease (Gvhd) After Post-Transplantation Cyclophosphamide Versus Conventional Gvhd Prophylaxis, Rima M Saliba, Amin M Alousi, Joseph Pidala, Mukta Arora, Stephen R Spellman, Michael T Hemmer, Tao Wang, Camille Abboud, Sairah Ahmed, Joseph H Antin, Amer Beitinjaneh, David Buchbinder, Michael Byrne, Jean-Yves Cahn, Hannah Choe, Rabi Hanna, Peiman Hematti, Rammurti T Kamble, Carrie L Kitko, Mary Laughlin, Lazaros Lekakis, Margaret L Macmillan, Rodrigo Martino, Parinda A Mehta, Taiga Nishihori, Sagar S Patel, Miguel-Angel Perales, Hemalatha G Rangarajan, Olov Ringdén, Joseph Rosenthal, Bipin N Savani, Kirk R Schultz, Sachiko Seo, Takanori Teshima, Marjolein Van Der Poel, Leo F Verdonck, Daniel Weisdorf, Baldeep Wirk, Jean A Yared, Jeffrey Schriber, Richard E Champlin, Stefan O Ciurea Oct 2022

Characteristics Of Graft-Versus-Host Disease (Gvhd) After Post-Transplantation Cyclophosphamide Versus Conventional Gvhd Prophylaxis, Rima M Saliba, Amin M Alousi, Joseph Pidala, Mukta Arora, Stephen R Spellman, Michael T Hemmer, Tao Wang, Camille Abboud, Sairah Ahmed, Joseph H Antin, Amer Beitinjaneh, David Buchbinder, Michael Byrne, Jean-Yves Cahn, Hannah Choe, Rabi Hanna, Peiman Hematti, Rammurti T Kamble, Carrie L Kitko, Mary Laughlin, Lazaros Lekakis, Margaret L Macmillan, Rodrigo Martino, Parinda A Mehta, Taiga Nishihori, Sagar S Patel, Miguel-Angel Perales, Hemalatha G Rangarajan, Olov Ringdén, Joseph Rosenthal, Bipin N Savani, Kirk R Schultz, Sachiko Seo, Takanori Teshima, Marjolein Van Der Poel, Leo F Verdonck, Daniel Weisdorf, Baldeep Wirk, Jean A Yared, Jeffrey Schriber, Richard E Champlin, Stefan O Ciurea

Center for Medical Ethics and Health Policy Staff Publications

Post-transplantation cyclophosphamide (PTCy) has been shown to effectively control graft-versus-host disease (GvHD) in haploidentical (Haplo) transplantations. In this retrospective registry study, we compared GvHD organ distribution, severity, and outcomes in patients with GvHD occurring after Haplo transplantation with PTCy GvHD prophylaxis (Haplo/PTCy) versus HLA-matched unrelated donor transplantation with conventional prophylaxis (MUD/conventional). We evaluated 2 cohorts: patients with grade 2 to 4 acute GvHD (aGvHD) including 264 and 1163 recipients of Haplo and MUD transplants; and patients with any chronic GvHD (cGvHD) including 206 and 1018 recipients of Haplo and MUD transplants, respectively. In comparison with MUD/conventional transplantation ± antithymocyte globulin …