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Full-Text Articles in Medicine and Health Sciences
Role Of Hepcidin In The Diagnosis Of Sepsis And Septic Shock In Children, Osman Yeşi̇lbaş, Esra Şevketoğlu, Burcu Bursal Duramaz, Hasan Serdar Kihtir, Asuman Gedi̇kbaşi, Mey Tali̇p Petmezci̇, Canan Baydemi̇r
Role Of Hepcidin In The Diagnosis Of Sepsis And Septic Shock In Children, Osman Yeşi̇lbaş, Esra Şevketoğlu, Burcu Bursal Duramaz, Hasan Serdar Kihtir, Asuman Gedi̇kbaşi, Mey Tali̇p Petmezci̇, Canan Baydemi̇r
Turkish Journal of Medical Sciences
Background/aim: The purpose of this study is to compare the diagnostic value of hepcidin level with the white blood cell (WBC), C-reactive protein (CRP), procalcitonin (PCT), and interleukin-6 (IL-6) levels in pediatric sepsis and septic shock. Materials and methods: A cohort of 89 individuals were divided into four groups: a healthy control group (HCG, n = 28), pediatric intensive care unit control group (PICUCG, n = 17), sepsis group (SG, n = 23), and septic shock group (SSG, n = 21). WBC, CRP, PCT, IL-6, and hepcidin levels were studied in the PICUCG, SG, and SSG, while hepcidin and IL-6 …
Investigation Of The Effect Of Ss-Lactam Antibiotics And Serum On Growth And Gene Expression In Escherichiacoli Strain Jj1886, Eli̇f Bozçal Dağdevi̇ren
Investigation Of The Effect Of Ss-Lactam Antibiotics And Serum On Growth And Gene Expression In Escherichiacoli Strain Jj1886, Eli̇f Bozçal Dağdevi̇ren
Turkish Journal of Medical Sciences
Background/aim: ß-Lactamase-producing Escherichia coli strain JJ1886 is an epidemic clone with high virulence properties. Because this strain can survive in the bloodstream, we aimed here to understand how ß-lactam antibiotics and human serum affect the growth and gene expression of this bacterium. Materials and methods: We report the time-dependent growth effect of normal human serum and heat-inactivated serum, together with ß-lactam antibiotics (including cefotaxime, ceftazidime, and carbenicillin), for E. coli strain JJ1886. Relative gene expression of ß-lactamase-related genes (encoding the ß-lactamase regulator, CTX-M-15, and peptidoglycan glycosyltransferase) and serum survival- associated genes (encoding lipoprotein NlpI, murein lipoprotein, lipopolysaccharide core heptose (I) …
Takayasu Arteritis: An Update, Gökhan Keser, Kenan Aksu, Rafi̇ Haner Di̇reskeneli̇
Takayasu Arteritis: An Update, Gökhan Keser, Kenan Aksu, Rafi̇ Haner Di̇reskeneli̇
Turkish Journal of Medical Sciences
Takayasu arteritis (TAK) is a challenging chronic, granulomatous, large-vessel systemic vasculitis, mostly due to difficulties in early diagnosis and assessing actual disease activity. Since there are no specific diagnostic laboratory tests, biomarkers, or autoantibodies, many patients experience considerable delay in diagnosis. Remembering the possibility of TAK together with the use of acute phase responses and appropriate imaging studies may be helpful for early diagnosis. Since there may be discrepancies between systemic and vascular wall inflammation, using only acute phase responses is not reliable in assessing current disease activity. Therefore, physical examination and new imaging findings should also be used to …
Comparison Between Laparoscopy And Laboratory Tests For The Diagnosis Of Tuberculous Peritonitis, Bo Huang, De Jun Cui, Ying Ren, Bin Han, Da Ping Yang, Xun Zhao
Comparison Between Laparoscopy And Laboratory Tests For The Diagnosis Of Tuberculous Peritonitis, Bo Huang, De Jun Cui, Ying Ren, Bin Han, Da Ping Yang, Xun Zhao
Turkish Journal of Medical Sciences
Background/aim: Our study aimed to investigate a reliable diagnostic approach for tuberculous peritonitis (TBP) by comparing the commonly used diagnostic tools. Materials and methods: Fifty-one patients had received a series of diagnoses, including laparoscopy, erythrocyte sedimentation rate (ESR), cancer antigen 125 (CA125), tuberculin skin test, tuberculosis antibody in serum (TB-Ab), the T-SPOT.TB test, or adenosine deaminase (ADA) in ascitic fluid. The positive rate of each method was calculated and the differences of positive rates between laparoscopy and laboratory tests that had higher positive rates were analyzed by McNemar chi-square test. Results: The most common symptoms and signs of 51 patients …
Effects Of Epidural Morphine And Levobupivacaine Combination Before Incision And Afterincision And In The Postoperative Period On Thoracotomy Pain And Stress Response, Güler Ayşe Barut, Mehtap Tunç, Şazi̇ye Şahi̇n, Fatma Ulus, Hi̇lal Sazak
Effects Of Epidural Morphine And Levobupivacaine Combination Before Incision And Afterincision And In The Postoperative Period On Thoracotomy Pain And Stress Response, Güler Ayşe Barut, Mehtap Tunç, Şazi̇ye Şahi̇n, Fatma Ulus, Hi̇lal Sazak
Turkish Journal of Medical Sciences
Background/aim: This study aims to investigate the effects of thoracic epidural analgesia, before and after surgical incision and in the postoperative period, on thoracotomy pain and stress response. Materials and methods: A total of 45 patients who were scheduled for posterolateral thoracotomy were included in this study. A combination of epidural levobupivacaine and morphine was administered as a bolus before incision (Group 1; n=15), after incision (Group 2; n=15), or at the end of surgery (Group 3; n=15). Additionally, infusion was used in Group 1 and Group 2 during operation. Postoperative patient-controlled epidural analgesia infusion pumps were connected to all …
Predictors Of Mortality In Cancer Patients Who Needintensive Care Unit Support: A Two Center Cohort Study, Özlem Edi̇boğlu, Sami̇ Cenk Kirakli, Özlem Yazicioğlu Moçi̇n, Gökay Güngör, Ceyda Anar, Pinar Çi̇men, Nalan Adigüzel, Cüneyt Saltürk, Meri̇h Kalamanoğlu Balci, Zuhal Karakurt, Dursun Ali̇zoroğlu
Predictors Of Mortality In Cancer Patients Who Needintensive Care Unit Support: A Two Center Cohort Study, Özlem Edi̇boğlu, Sami̇ Cenk Kirakli, Özlem Yazicioğlu Moçi̇n, Gökay Güngör, Ceyda Anar, Pinar Çi̇men, Nalan Adigüzel, Cüneyt Saltürk, Meri̇h Kalamanoğlu Balci, Zuhal Karakurt, Dursun Ali̇zoroğlu
Turkish Journal of Medical Sciences
Background/aim: Cancer patients frequently need intensive care support due to respiratory failure. We aimed to evaluate the predictors of mortality in cancer patients who were admitted to the intensive care unit (ICU). Materials and methods: This study was performed in the ICUs of two centers between 1 January 2008 and 31 December 2015. Demographic data, cancer type, causes of respiratory failure, comorbidities, APACHE II scores, treatments, and mortality rates were recorded. Results: A total number of 583 cancer patients (477 males) were enrolled from the two centers. Of those, 472 patients had lung cancer (81%), while 111 had extrapulmonary malignancies …
What Has Changed In The Utility Of Pediatric Eeg Over The Last Decade?, Leman Teki̇n Orgun, Ebru Arhan, Kürşad Aydin, Tunzale Rzayeva, Tuğba Hirfanoğlu, Ayşe Serdaroğlu
What Has Changed In The Utility Of Pediatric Eeg Over The Last Decade?, Leman Teki̇n Orgun, Ebru Arhan, Kürşad Aydin, Tunzale Rzayeva, Tuğba Hirfanoğlu, Ayşe Serdaroğlu
Turkish Journal of Medical Sciences
Background/aim: We evaluated the utility of electroencephalography (EEG) in children with neurological conditions and compared the results with those of our previous study on excessive uses of pediatric EEG, which was published in 2003. We also evaluated the possibility of subsequent EEGs and satisfactory duration of EEG recordings according to EEG type and admission status. We also evaluated the yield of varying durations of EEG recordings. Materials and methods: All consecutive pediatric EEG records performed at Gazi University EEG laboratory during a 1-year period were retrospectively reviewed. The indications of EEGs, the number of EEGs for each patient, condition and …
Repaglinide Inhibits Cyclosporine A-Induced Renal Tubular Toxicityby Affecting Apoptosis And Bax And Bcl-2 Expression, Jin Li, Hui Li, Qi Xiong Li, Ying Xue
Repaglinide Inhibits Cyclosporine A-Induced Renal Tubular Toxicityby Affecting Apoptosis And Bax And Bcl-2 Expression, Jin Li, Hui Li, Qi Xiong Li, Ying Xue
Turkish Journal of Medical Sciences
Background/aim: Repaglinide (RG) is a prandial glucose regulator used for the treatment of type 2 diabetes. Our recent study showed that RG plays an important role in cyclosporine A (CsA)-induced nephrotoxicity through its antioxidant properties. However, it is not known whether or not RG has any protective effect on CsA-induced renal tubular toxicity by affecting apoptosis and expression of apoptosis-associated protein. The purpose of this study was to investigate the effects of RG on CsA-induced renal tubule apoptosis and Bax and Bcl-2 protein expression in rats. Materials and methods: Forty male Sprague Dawley rats weighing 250-300 g were randomly divided …
Phenotypic Spectrum Of Charge Syndrome Based On Clinical Characteristics, Özge Aksel Kiliçarslan, Esra Ataman, Semra Gürsoy, Fi̇li̇z Hazan, Nadi̇de Cemre Randa, Tufan Çankaya, Murat Derya Erçal, Ayfer Ülgenalp, Özlem Gi̇ray Bozkaya
Phenotypic Spectrum Of Charge Syndrome Based On Clinical Characteristics, Özge Aksel Kiliçarslan, Esra Ataman, Semra Gürsoy, Fi̇li̇z Hazan, Nadi̇de Cemre Randa, Tufan Çankaya, Murat Derya Erçal, Ayfer Ülgenalp, Özlem Gi̇ray Bozkaya
Turkish Journal of Medical Sciences
Background/aim: CHARGE syndrome is a rare autosomal dominant disease with multiple congenital anomalies and cognitive impairment, which is caused by mutations in the CHD7 gene. This study aimed to disclose the mild end of the phenotypic spectrum of CHARGE syndrome, which has a highly variable expressivity. Materials and methods: Twenty-one patients who had at least one of the major symptoms of CHARGE syndrome (coloboma, choanal atresia, characteristic ear anomalies, semicircular canal hypoplasia, and cranial nerve anomalies) were included in the study. All patients were tested for karyotype analysis and CHD7 gene mutation/deletion. Results: In the study population, 6 different mutations …
Immunohistochemical Localization Of Podoplanin In The Placentas Of Hiv-Positivepreeclamptic Women, Onankoy Onyangunga, Jagidesda Moodley, Frederick Odun-Ayo, Thajasvarie Naicker
Immunohistochemical Localization Of Podoplanin In The Placentas Of Hiv-Positivepreeclamptic Women, Onankoy Onyangunga, Jagidesda Moodley, Frederick Odun-Ayo, Thajasvarie Naicker
Turkish Journal of Medical Sciences
Background/aim: Impaired lymphatic function is associated with pathological conditions. The presence of placental lymphatics is still under debate. This study evaluates the placental podoplanin expression in normotensive and preeclamptic women with and without HIV. Materials and methods: Normotensive (n = 60) and preeclamptic (n = 120) pregnant women were stratified into early and late onset preeclampsia and further divided by HIV status. Immunostaining was performed using the podoplanin antibody prior to the morphometric image analysis. Results: Podoplanin was immunolocalized in a reticular-like stroma complex within the exchange and conducting villi. The immunoexpression of podoplanin was significantly upregulated in the exchange …
The Use Of Rapid Antigen Testing And Matrix-Assisted Laser Desorption/Ionization-Timeof Flight Mass Spectrometry In The Diagnosis Of Group A Beta-Hemolytic Streptococci Inthroat Swab Samples, Ridvan Deni̇z, Eli̇f Aktaş Sepetci̇, Ayşe Bariş, Banu Bayraktar
The Use Of Rapid Antigen Testing And Matrix-Assisted Laser Desorption/Ionization-Timeof Flight Mass Spectrometry In The Diagnosis Of Group A Beta-Hemolytic Streptococci Inthroat Swab Samples, Ridvan Deni̇z, Eli̇f Aktaş Sepetci̇, Ayşe Bariş, Banu Bayraktar
Turkish Journal of Medical Sciences
Background/aim: We aimed to evaluate the efficacy of a rapid antigen test in detecting group A beta-hemolytic streptococci (GAS) in throat samples in comparison with the culture method and to compare the efficiency of matrix-assisted laser desorption/ionization-time of flight mass spectrometry (MALDI-TOF MS) and traditional methods in identifying GAS in cultures. Materials and methods: A total of 3668 throat samples from patients with a prediagnosis of tonsillopharyngitis were assessed by the QuickVue+Strep A antigen test and culture. For GAS identification from cultures, bacitracin sensitivity, PYR, and latex agglutination tests and MALDI-TOF MS were used. Results: A total of 567 (15.5%) …
Clinicopathological Characteristics And Mutation Profile Of Braf And Nras Mutation Incutaneous Melanomas In The Western Turkish Population, Mustafa Kürşat Evrenos, Peyker Temi̇z, Fethi̇ Sirri Çam, Murat Yaman, Levent Yoleri̇, Ayli̇n Türel Ermertcan
Clinicopathological Characteristics And Mutation Profile Of Braf And Nras Mutation Incutaneous Melanomas In The Western Turkish Population, Mustafa Kürşat Evrenos, Peyker Temi̇z, Fethi̇ Sirri Çam, Murat Yaman, Levent Yoleri̇, Ayli̇n Türel Ermertcan
Turkish Journal of Medical Sciences
Background/aim: Malignant melanoma is the most common cause of death due to skin cancers. The most common mutations in RAFRAS pathway from tumor oncogenes are BRAF and NRAS. In this study, we analyzed the frequency of BRAF and NRAS gene mutations and investigated their association with clinicopathological features of melanomas in the Turkish population. Materials and methods: 65 primary cutaneous melanoma were included in the study. The mutations were evaluated with real-time PCRbased PCR-array through allele-specific amplification, and the results were correlated with various clinicopathological characteristics. Results: 52.3% of the patients were female and 47.7% were male. The mean age …
Effects Of Tourniquet Usage In Lower Extremity Surgery On Optic Nerve Sheath Diameter, Ahmet Beşi̇r, Ersagun Tuğcugi̇l
Effects Of Tourniquet Usage In Lower Extremity Surgery On Optic Nerve Sheath Diameter, Ahmet Beşi̇r, Ersagun Tuğcugi̇l
Turkish Journal of Medical Sciences
Background/aim: The aim of this study was to evaluate changes in intracranial pressure following tourniquet deflation using noninvasive ultrasonographic optic nerve sheath diameter (ONSD) measurements. Materials and methods: Our study included 59 adult patients between the ages of 18 and 65 years from the American Society of Anesthesiologists (ASA) I/II risk groups who were scheduled to undergo elective orthopedic surgery of the lower extremities using a tourniquet under general anesthesia. ONSD and end-tidal CO2 (ETCO2) were measured 5 times: 15 min prior to the anesthesia induction; just prior to the deflation of the tourniquet; and at 5, 10, and 15 …
Determining The Effect Of Long-Term Dexamethasone And Prednisolone Treatment Onsugammadex, Ebru Bi̇ri̇ci̇k, Ersel Güleç, Işil Öcal, Mehmet Bertan Yilmaz, Feri̇de Karacaer, Di̇lek Özcengi̇z
Determining The Effect Of Long-Term Dexamethasone And Prednisolone Treatment Onsugammadex, Ebru Bi̇ri̇ci̇k, Ersel Güleç, Işil Öcal, Mehmet Bertan Yilmaz, Feri̇de Karacaer, Di̇lek Özcengi̇z
Turkish Journal of Medical Sciences
Background/aim: We aimed to investigate the effect of long-term use of dexamethasone and prednisolone on the reversal effect of sugammadex. Materials and methods: TTwenty-four male Wistar albino rats were divided into three groups. Dexamethasone (600 µg/kg) was given to group D, prednisolone (10 mg/kg) was given to group P, and an equivalent volume of saline per day was administered intraperitoneally to group S for 14 days, respectively. The left hemidiaphragm with attached phrenic nerve was maintained in Krebs solution. Sugammadex (30 µmol/L) was applied while rocuronium (10 µmol/L) was present in an organ bath and a single twitch was obtained. …
Serum Adma, Endothelial Dysfunction, And Atherosclerosis In Hypervolemichemodialysis Patients, İbrahi̇m Doğan, Bariş Eser, Sultan Özkurt, Özlem Yayar, Bülent Özgür, Hüseyi̇n Kayadi̇bi̇, Tolga Doğan, Ahmet Musmul, Mehmet Soydan
Serum Adma, Endothelial Dysfunction, And Atherosclerosis In Hypervolemichemodialysis Patients, İbrahi̇m Doğan, Bariş Eser, Sultan Özkurt, Özlem Yayar, Bülent Özgür, Hüseyi̇n Kayadi̇bi̇, Tolga Doğan, Ahmet Musmul, Mehmet Soydan
Turkish Journal of Medical Sciences
Background/aim: Asymmetric dimethyl arginine (ADMA) is a strong predictor of cardiovascular disease and mortality in patients under hemodialysis treatment. We aimed to investigate the relationship among volume status, endothelial dysfunction, and ADMA in hemodialysis patients. Materials and methods: A total of 120 patients with a history of hemodialysis treatment were included. ADMA and CRP were measured. Echocardiographic evaluation and carotid artery intima-media thickness (CIMT) measurements were performed. Patients were divided into two groups according to clinical evaluation, ultrafiltration rate, vena cava inferior diameter (VCI), and cardiothoracic index (CTI); the two groups were hypervolemic and normovolemic. Results: The hypervolemic group included …
The Effect Of Obstructive Sleep Apnea Syndrome On The Central Auditory System, Ayşe İri̇z, Mehmet Düzlü, Oğuz Köktürk, Yusuf Kemal Kemaloğlu, Faki̇h Ci̇hat Eravci, Işik Si̇bel Küçükünal, Recep Karamert
The Effect Of Obstructive Sleep Apnea Syndrome On The Central Auditory System, Ayşe İri̇z, Mehmet Düzlü, Oğuz Köktürk, Yusuf Kemal Kemaloğlu, Faki̇h Ci̇hat Eravci, Işik Si̇bel Küçükünal, Recep Karamert
Turkish Journal of Medical Sciences
Background/aim: Obstructive sleep apnea syndrome (OSAS) is a disease characterized by repeated hypoxia attacks during sleep. The effect of hypoxia on the central nervous system is a well-known entity. In this study we aimed to investigate the effect of OSAS on the central auditory system. Materials and methods: Twenty-one OSAS patients diagnosed by polysomnography (PSG) and 10 control subjects were included in the study. After a thorough otorhinolaryngology examination, all subjects underwent pure tone audiometry (250 to 8000 Hz frequency). The subjects with normal otoscopic examination and hearing threshold were included in the study. All participants underwent speech discrimination analyses …
Advantages Of B-Mode Ultrasound Combined With Strain Elastography In Differentiation Of Idiopathic Granulomatous Mastitis From Malignant Breast Lesions, Serdar Arslan, Fati̇h Öncü, M. Ali̇ Eryilmaz, Mehmet Sedat Durmaz, Ayşegül Altunkeser, Yaşar Ünlü
Advantages Of B-Mode Ultrasound Combined With Strain Elastography In Differentiation Of Idiopathic Granulomatous Mastitis From Malignant Breast Lesions, Serdar Arslan, Fati̇h Öncü, M. Ali̇ Eryilmaz, Mehmet Sedat Durmaz, Ayşegül Altunkeser, Yaşar Ünlü
Turkish Journal of Medical Sciences
Background/aim: To evaluate the diagnostic performance of strain elastography (SE) combined with B-mode ultrasound in distinguishing between idiopathic granulomatous mastitis (IGM) and malignant breast lesions. Materials and methods: Seventy-seven malignant breast lesions and 36 IGM were assessed using B-mode ultrasound and SE. Ultrasonographic findings for all the breast lesions were classified based on the 2013 American College of Radiology Breast Imaging Reporting and Data System (BI-RADS-US), and the SE findings were evaluated based on the strain ratio and a five-point scale. The diagnostic performances of B-mode ultrasonography, SE, and the combination of both methods were compared. Results: Significant differences in …
Cpr-Related Thoracic Injuries: Comparison Of Cpr Guidelines Between 2010 And 2015, Kaan Yusufoğlu, Mehmet Özgür Erdoğan, İsmai̇l Tayfur, Mustafa Ahmet Afacan, Şahi̇n Çolak
Cpr-Related Thoracic Injuries: Comparison Of Cpr Guidelines Between 2010 And 2015, Kaan Yusufoğlu, Mehmet Özgür Erdoğan, İsmai̇l Tayfur, Mustafa Ahmet Afacan, Şahi̇n Çolak
Turkish Journal of Medical Sciences
Background/aim: This study aimed to evaluate traumatic thorax complications in post-CPR patients and to investigate whether or not there has been a decrease in these complications since the adoption of current chest compression recommendations. Materials and methods: Post-CPR patients with return of spontaneous circulation (ROSC) were admitted between January 2014 and January 2016 were analyzed retrospectively. Patients admitted to the ED in 2014 were resuscitated according to 2010 AHA CPR guidelines, while those admitted to the ED in 2015 were resuscitated according to current ERC CPR guidelines. Results: The study population comprised 48 male and 35 female patients. Of the …
Efficacy Of Adhesive Strips To Reduce Postoperative Periorbital Edema And Ecchymosis Following Rhinoplasty, Sedat Tatar, Mehmet Hakan Bulam, Selahatti̇n Özmen
Efficacy Of Adhesive Strips To Reduce Postoperative Periorbital Edema And Ecchymosis Following Rhinoplasty, Sedat Tatar, Mehmet Hakan Bulam, Selahatti̇n Özmen
Turkish Journal of Medical Sciences
Background/aim: Periorbital edema and ecchymosis may develop following rhinoplasty. The aim of this study was to assess the efficacy of adhesive strip application on the upper and lower eyelids to reduce postoperative edema and ecchymosis following rhinoplasty. Materials and methods: The eyelids of one side were randomly selected, and an adhesive strip of standard size and number was applied at the end of the operation. The strips were removed at postoperative day 3; photos of the eyes were taken at days 3 and 7. Edema and ecchymosis were graded on a scale from 1 to 4. The ecchymosis areas on …
Validity And Reliability Of The Turkish Version Of The Dsm-5 Generalized Anxiety Disorder Severity Scale For Children Aged 11-17 Years, Şermi̇n Yalin Sapmaz, Handan Özek Erkuran, Di̇lek Ergi̇n, Masum Öztürk, Nesri̇n Şen Celasi̇n, Duygu Karaarslan, Ömer Aydemi̇r
Validity And Reliability Of The Turkish Version Of The Dsm-5 Generalized Anxiety Disorder Severity Scale For Children Aged 11-17 Years, Şermi̇n Yalin Sapmaz, Handan Özek Erkuran, Di̇lek Ergi̇n, Masum Öztürk, Nesri̇n Şen Celasi̇n, Duygu Karaarslan, Ömer Aydemi̇r
Turkish Journal of Medical Sciences
Background/aim: This study aimed to assess the validity and reliability of the Turkish version of the DSM-5 Generalized Anxiety Disorder Severity Scale - Child Form. Materials and methods: The study sample consisted of 32 patients treated in a child psychiatry unit and diagnosed with generalized anxiety disorder and 98 healthy volunteers who were attending middle or high school during the study period. For the assessment, the Screen for Child Anxiety and Related Emotional Disorders (SCARED) was also used along with the DSM-5 Generalized Anxiety Disorder Severity Scale - Child Form. Results: Regarding reliability analyses, the Cronbach alpha internal consistency coefficient …
Appraisal Of The ″Pediatric Ards: Consensus Recommendations From The Pediatric Acute Lung Injury Consensus Conference″ With The Agree Ii Instrument, Orkun Tolunay, İlknur Tolunay, Riza Di̇nçer Yildizdaş, Tamer Çeli̇k, Ümi̇t Çeli̇k
Appraisal Of The ″Pediatric Ards: Consensus Recommendations From The Pediatric Acute Lung Injury Consensus Conference″ With The Agree Ii Instrument, Orkun Tolunay, İlknur Tolunay, Riza Di̇nçer Yildizdaş, Tamer Çeli̇k, Ümi̇t Çeli̇k
Turkish Journal of Medical Sciences
Background/aim: The ″Pediatric Acute Lung Injury Consensus Conference″ (PALICC) was convened in order to develop a taxonomy to define pediatric acute respiratory distress syndrome (ARDS). The Appraisal of Guidelines for Research and Evaluation (AGREE) assesses the quality of guidelines. The aim of this study is to evaluate the new pediatric ARDS guideline using the AGREE II instrument. To the best of our knowledge, this is the first assessment of the new pediatric ARDS clinical practice guideline in the English literature. Materials and methods: Four appraisers assessed the new pediatric ARDS guideline with the AGREE II instrument. At the end of …
Bedside Measurement Of The Optic Nerve Sheath Diameterwith Ultrasound In Cerebrovascular Disorders, Yücel Yüzbaşioğlu, Sema Yüzbaşioğlu, Selçuk Coşkun, Ferhat İçme, Tolga Öz, Refi̇k Kunt, Si̇nan Becel, Emi̇ne Akçay, Havva Şahi̇n Kavakli
Bedside Measurement Of The Optic Nerve Sheath Diameterwith Ultrasound In Cerebrovascular Disorders, Yücel Yüzbaşioğlu, Sema Yüzbaşioğlu, Selçuk Coşkun, Ferhat İçme, Tolga Öz, Refi̇k Kunt, Si̇nan Becel, Emi̇ne Akçay, Havva Şahi̇n Kavakli
Turkish Journal of Medical Sciences
Background/aim: We aimed to show the role of determination of optic nerve sheath diameter (ONSD) by bedside ultrasonography in an emergency department in the diagnosis of cerebrovascular disorders and its correlation with the clinical picture. Materials and methods: This prospective cross-sectional study included 55 patients with cerebrovascular disorders and 53 controls. Age, sex, ONSD, comorbid disease status, and multidetector computed tomography results of all subjects and application periods and National Institutes of Health Stroke Scale (NIHSS) scores of the patient group were evaluated. Results: The ONSD of the patient and control groups was determined as a median of 5.7 mm …
Prognostic Value Of Interferon-Gamma, Interleukin-6, And Tumor Necrosis Factor-Alpha In The Radiation Response Of Patients Diagnosed With Locally Advanced Non-Small-Cell Lung Cancer And Glioblastoma Multiforme, Çi̇ğdem Damla Deni̇z, Mehmet Gürbi̇lek, Mehmet Koç
Prognostic Value Of Interferon-Gamma, Interleukin-6, And Tumor Necrosis Factor-Alpha In The Radiation Response Of Patients Diagnosed With Locally Advanced Non-Small-Cell Lung Cancer And Glioblastoma Multiforme, Çi̇ğdem Damla Deni̇z, Mehmet Gürbi̇lek, Mehmet Koç
Turkish Journal of Medical Sciences
Background/aim: This study aimed to investigate the effect of chemoradiotherapy (CRT) on interferon-gamma (IFN-γ), interleukin-6 (IL-6), and tumor necrosis factor-alpha (TNF-α), which are critical markers of the clinical radiation response of patients with locally advanced non-small-cell lung cancer (NSCLC) and glioblastoma multiforme (GBM). Materials and methods: Thirty patients who were treated with CRT and 20 healthy controls were prospectively evaluated. Circulating levels of cytokines were measured by enzyme-linked immunosorbent assay procedure. Post-CRT and pre-CRT levels were compared. Results: Post-CRT, TNF-α and IFN-γ levels were significantly lower than pre-CRT levels in the NSCLC and GBM groups, respectively. The statistical analysis did …
Retinopathy Of Prematurity In Extremely Premature Infants: Multiplebirths Versus Single Births, İkbal Seza Petri̇çli̇, Caner Kara, Ni̇hal Demi̇rel, Di̇lek Ulubaş Işik, Ahmet Yağmur Baş
Retinopathy Of Prematurity In Extremely Premature Infants: Multiplebirths Versus Single Births, İkbal Seza Petri̇çli̇, Caner Kara, Ni̇hal Demi̇rel, Di̇lek Ulubaş Işik, Ahmet Yağmur Baş
Turkish Journal of Medical Sciences
Background/aim: This study aimed to compare the incidence of any stage of retinopathy of prematurity (ROP) and type 1 ROP between extremely preterm multiple- and single-birth infants. Materials and methods: In this retrospective study, we included extremely preterm infants who were ≤27 weeks of gestational age at birth. The screened infants were divided into two groups: single and multiple births. The incidence of any stage of ROP and type 1 ROP was compared between the groups. Results: This study included 301 infants; 225 were in the single-birth group and 76 were in multiple-birth group. The incidences of any stage of …
Bservational Study Of Dermatological Manifestations In Patients Admitted To Atertiary Poison Center In Iran, Haleh Talaie, Soheila Nasiri, Mehdi Gheisari, Sahar Dadkhahfar, Soma Ahmadi
Bservational Study Of Dermatological Manifestations In Patients Admitted To Atertiary Poison Center In Iran, Haleh Talaie, Soheila Nasiri, Mehdi Gheisari, Sahar Dadkhahfar, Soma Ahmadi
Turkish Journal of Medical Sciences
Background/aim: Acute unintentional and deliberate poisoning by medications and chemicals is a frequent emergency, especially in Iran. This study aimed to evaluate the frequency and character of skin findings occurring in patients with acute intentional and aunintentional poisoning. Materials and methods: This prospective observational study was performed at the Loghman Hakim Hospital Poison Center over a period of 6 months from April 2016 to September 2016. Data including patient demographics, cause of poisoning, and level of consciousness were collected. Pediatric patients (under the age of 13) and patients who died in the first hours of admission were excluded from the …
Biofilm Formation In Uropathogenic Escherichia Coli: Association With Adhesion Factor Genes, Hojjatolah Zamani, Ali Salehzadeh
Biofilm Formation In Uropathogenic Escherichia Coli: Association With Adhesion Factor Genes, Hojjatolah Zamani, Ali Salehzadeh
Turkish Journal of Medical Sciences
Background/aim: Biofilm formation is a major determinant factor in the development of urinary tract infections (UTIs) by uropathogenic Escherichia coli (UPEC). Several adhesion factors are involved in attachment of bacterial cells to the urinary tract and biofilm development. Materials and methods: The possible relationship between different adhesion factor genes (AFGs) and biofilm formation among UPEC isolates was investigated. Prevalence of different AFGs including fimA, fimH, papAH, papC, papEF, sfa-S, foc/G, and bmaE and their association to biofilm formation were investigated. Phenotypic expression of type 1 and P fimbriae was also investigated. Results: Our results showed that 84% of UPEC were …
Investigation Of The Relationship Between Oxidative Stress Andscube1 Levels In High Fat Diet-Induced Obese Rats, Akin Bodur, Cemi̇l Kahraman, Di̇ler Us Altay, Taghi Ahmadi Rendi, Ahmet Menteşe, Ahmet Alver
Investigation Of The Relationship Between Oxidative Stress Andscube1 Levels In High Fat Diet-Induced Obese Rats, Akin Bodur, Cemi̇l Kahraman, Di̇ler Us Altay, Taghi Ahmadi Rendi, Ahmet Menteşe, Ahmet Alver
Turkish Journal of Medical Sciences
Background/aim: This study aimed to investigate signal peptide-Cub-EGF domain-containing protein 1 (SCUBE1) levels and oxidative stress (OS) in a high fat diet (HFD)-induced obese rat model. Materials and methods: Fourteen rats were randomly divided into two groups. Group 1, the control group, was given a standard diet (10% calories of fat) and Group 2, the obese group, was given a HFD (60% calories of fat), both for 70 days. Rats were then sacrificed and serum samples were collected. Serum glucose and triglyceride concentrations were determined using an autoanalyzer. Serum SCUBE1, adiponectin, and plasminogen activator inhibitor-1 levels were determined using an …
Reliability And Validity Of The Turkish Nose Obstruction Symptom Evaluation (Nose) Scale, Serdar Karahatay, Hamdi̇ Taşli, Ömer Karakoç, Ümi̇t Aydin, Türker Türker
Reliability And Validity Of The Turkish Nose Obstruction Symptom Evaluation (Nose) Scale, Serdar Karahatay, Hamdi̇ Taşli, Ömer Karakoç, Ümi̇t Aydin, Türker Türker
Turkish Journal of Medical Sciences
Background/aim: e aim of this study was to validate the Turkish Nasal Obstruction Symptom Evaluation (T-NOSE) scale. Materials and methods: e NOSE scale was translated into Turkish. A prospective study was conducted involving adult subjects with nasal obstruction and a control group. e patients were divided into three groups, namely nasal septum deviation (NSD), septoplasty, and control groups. Internal consistency, test-retest reliability, validity, responsiveness, and the magnitude of the e ect of surgery were all investigated. Results: In total, 253 subjects were enrolled in the study. Cronbach?s alpha was 0.938 and 0.942 upon test and retest, respectively, which proved good …
Peritoneal Dialysis In Neonates: Six Years Of Single Center Experience, Ferda Özlü, Hacer Yapicioğlu Yildizdaş, Gül Şeker, Hüseyi̇n Şi̇mşek, Aysun Karabay Bayazit, Mehmet Satar
Peritoneal Dialysis In Neonates: Six Years Of Single Center Experience, Ferda Özlü, Hacer Yapicioğlu Yildizdaş, Gül Şeker, Hüseyi̇n Şi̇mşek, Aysun Karabay Bayazit, Mehmet Satar
Turkish Journal of Medical Sciences
Background/aim: Peritoneal dialysis (PD) is generally considered the practical dialysis modality for neonates in the treatment of acute kidney injury (AKI) and metabolic disturbances. e aim of this study was to evaluate the indications, complications, and outcomes of PD between January 2011 and December 2016. Materials and methods: This study included all 56 neonates that underwent PD over six years in our neonatal intensive care unit (NICU). A retrospective chart review was performed for all patients in our institution. Results: The incidence of PD was 1.32% (56/4230 patients) during this period. Mean birth weight of the patients was 2267.77 ± …
Analysis Of Partial Azfc (Gr/Gr, B1/B3, And B2/B3) Deletions In Iranian Oligozoospermia Candidates For Intracytoplasmic Sperm Injection (Icsi), Mitra Ataei, Fatemeh Akbarian, Mahba Ataei Talebi, Peyman Dolati, Maryam Mobaraki, Abolfazl Faraji, Massoud Houshmand
Analysis Of Partial Azfc (Gr/Gr, B1/B3, And B2/B3) Deletions In Iranian Oligozoospermia Candidates For Intracytoplasmic Sperm Injection (Icsi), Mitra Ataei, Fatemeh Akbarian, Mahba Ataei Talebi, Peyman Dolati, Maryam Mobaraki, Abolfazl Faraji, Massoud Houshmand
Turkish Journal of Medical Sciences
Background/aim: Infertility is a main health issue. e human Y chromosome contains essential genes for spermatogenesis, especially those located on four major intervals de ned as AZFa, AZFb, AZFc, and AZFd. A partial deletion of the AZFc region is reported as a signi cant risk factor for oligo-/azoospermia. e main purpose of this study was to investigate the prevalence of partial deletions in the AZFc region (gr/gr, b1/b3, and b2/b3) in Iranian oligozoospermic candidates for intracytoplasmic sperm injection. Materials and methods: Multiplex PCR was used to assess the micro and partial deletions in 60 oligozoospermia infertile and 80 fertile men. …