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Full-Text Articles in Medicine and Health Sciences

The Effects Of On-Pump And Off-Pump Coronary Artery Bypass Surgery On Oxidative Stress And Cerebral Oxygenation: A Prospective Observational Study, Ökkeş Hakan Mi̇ni̇ksar, Sameh Alagha, Ferit Çi̇çekçi̇oğlu, Mehtap Honca, Ayşe Yeşim Göçmen Jan 2024

The Effects Of On-Pump And Off-Pump Coronary Artery Bypass Surgery On Oxidative Stress And Cerebral Oxygenation: A Prospective Observational Study, Ökkeş Hakan Mi̇ni̇ksar, Sameh Alagha, Ferit Çi̇çekçi̇oğlu, Mehtap Honca, Ayşe Yeşim Göçmen

Turkish Journal of Medical Sciences

In this prospective observational study, our goal was to investigate the relationship between serum levels of oxidative stress (OS) parameters and regional cerebral oxygen saturation (rSO2) in addition to evaluating postoperative clinical outcomes among patients undergoing coronary artery bypass graft surgery (CABG).Materials and methods: This study comprised 64 adult patients undergoing elective CABG (on-pump [n = 48] and off-pump [n = 16]) procedures. Serum OS levels and rSO2 values were measured intraoperatively at three specific time points: T1 (after induction), T2 (15 min before aortic cross-clamp removal or the final distal anastomosis), and T3 (15 min after aortic cross-clamp removal …


Effect Of Humic Acid On Oxidative Stress And Neuroprotection In Traumatic Spinal Cord Injury: An Experimental Study, Burak Kinali, Nail Özdemi̇r, Ali Karadağ, Özge Kaya Korkmaz, Ayşe Gülden Di̇ni̇z, Fatma Demet Arslan Jan 2024

Effect Of Humic Acid On Oxidative Stress And Neuroprotection In Traumatic Spinal Cord Injury: An Experimental Study, Burak Kinali, Nail Özdemi̇r, Ali Karadağ, Özge Kaya Korkmaz, Ayşe Gülden Di̇ni̇z, Fatma Demet Arslan

Turkish Journal of Medical Sciences

Traumatic spinal cord injury (TSCI) is an important health problem, especially in developing countries withadditional socioeconomic loss. Humic acid (HA) usually has antioxidant, antiinflammatory, blood circulating, and antiviral effects.Hence, it was aimed herein to show the effect of HA on neuroprotection in a TSCI model.Materials and method: A TSCI model was used, in which 24 Wistar albino rats were divided into 4 groups: control group: subjectedto only laminectomy; sham group: subjected to laminectomy + TSCI; HA 5 mg/kg group: subjected to laminectomy + TSCI +intraperitoneal (IP) injection of 5 mg/kg of HA; and HA 10 mg/kg group: subjected to laminectomy …


The Evaluation Of Oxidative Stress And Inflammation Markers In Serum And Saliva Of The Patients With Temporomandibular Disorders, Di̇lara Kazan, Burcu Baş, Abdurrahman Aksoy, Enes Atmaca Dec 2023

The Evaluation Of Oxidative Stress And Inflammation Markers In Serum And Saliva Of The Patients With Temporomandibular Disorders, Di̇lara Kazan, Burcu Baş, Abdurrahman Aksoy, Enes Atmaca

Turkish Journal of Medical Sciences

Background/aim: Temporomandibular Disorders (TMD), as in the occurrence of many diseases, have been associated with oxidative stress (OS) resulting from the disruption of antioxidant mechanisms and the accumulation of reactive oxygen species in tissues. This study was designed to compare salivary and serum OS and inflammation markers of individuals with TMD and healthy subjects. Materials and methods: A prospective cross-sectional study was conducted. Twenty-seven TMD patients diagnosed with disc displacement (DD) according to Research Diagnostic Criteria for Temporomandibular Disorders (RDC/TMD) and 17 healthy subjects were enrolled in the study. Prior to any treatment, serum, and saliva samples were taken from …


Dynamic Thiol-Disulfide Homeostasis As An Oxidative Stress Marker In Ankylosing Spondylitis And Undifferentiated Spondyloarthropathy, Cemaleddi̇n Öztürk, Şükran Erten, Murat Alişik, İsmai̇l Doğan, Güni̇z Yanik Üstüner, Sali̇m Neşeli̇oğlu, Özcan Erel Oct 2023

Dynamic Thiol-Disulfide Homeostasis As An Oxidative Stress Marker In Ankylosing Spondylitis And Undifferentiated Spondyloarthropathy, Cemaleddi̇n Öztürk, Şükran Erten, Murat Alişik, İsmai̇l Doğan, Güni̇z Yanik Üstüner, Sali̇m Neşeli̇oğlu, Özcan Erel

Turkish Journal of Medical Sciences

Background/aim: Seronegative spondyloarthropathies (SpA) are a group of chronic diseases characterized by axial inflammation, oligoarthritis, and enthesitis. Oxidative stress may contribute to a wide range of rheumatologic diseases, including SpA. This prospective case-control study was designed to compare thiol-disulfide levels as a marker of oxidative stress between SpA patients and healthy controls. Materials and methods: A total of 144 patients diagnosed with undifferentiated spondyloarthropathy (USpA, n = 97) or ankylosing spondylitis (AS, n = 47) were included along with 80 healthy controls. Serum native thiol (NT), total thiol (TT), and disulfide (D) levels were measured using the fully automated Erel …


In Vitro Hepatotoxicity Evaluation Of Methotrexate-Loaded Niosome Formulation: Fabrication, Characterization And Cell Culture Studies, Ahmet Doğan Ergi̇n, Çağatay Oltulu, Nebi̇ye Peli̇n Türker, Gülen Meli̇ke Demi̇rbolat Aug 2023

In Vitro Hepatotoxicity Evaluation Of Methotrexate-Loaded Niosome Formulation: Fabrication, Characterization And Cell Culture Studies, Ahmet Doğan Ergi̇n, Çağatay Oltulu, Nebi̇ye Peli̇n Türker, Gülen Meli̇ke Demi̇rbolat

Turkish Journal of Medical Sciences

Background/aim: Methotrexate (MTX) is a folic acid antagonist that is widely used to treat osteosarcoma, leukemia, breast cancer, and autoimmune and inflammatory diseases. The most important concerns with MTX are its poor solubility and high toxicity, particularly in liver cells. To enhance its solubility and to minimize its toxicity, we encapsulated MTX in niosomes and investigated its hepatotoxicity mechanisms using genetic biomarkers. Materials and methods: Niosomes were successfully prepared using a modified thin film method, and the prepared monodisperse smallsized formulation was subsequently characterized. In vitro cytotoxicity studies were performed both in hepatocarcinoma (HEP3G) and healthy liver (AML12) cell lines. …


Can Amniotic Fluid Protect Developing Fetal Lungs Against The Harmful Effects Of Oxidative Stress?, Levent Korkmaz, Cumali̇ Alan, İsmai̇l Topal, Mahi̇r Tayfur, Ali̇seydi̇ Bozkurt, Cebrai̇l Gürsul, Osman Baştuğ Jan 2023

Can Amniotic Fluid Protect Developing Fetal Lungs Against The Harmful Effects Of Oxidative Stress?, Levent Korkmaz, Cumali̇ Alan, İsmai̇l Topal, Mahi̇r Tayfur, Ali̇seydi̇ Bozkurt, Cebrai̇l Gürsul, Osman Baştuğ

Turkish Journal of Medical Sciences

Background/aim: Preterm births cause fetuses to be born without completing the development of their organs. Due to this undesirable situation, it is the pulmonary tissue which has to be most exposed to harmful effects of extrauterine environment. Early disappearance of the prophylactic and constructive effects of amniotic fluid (AF) on developing tissues, such as pulmonary tissue, facilitates the formation of pulmonary morbidities resulting from oxygen. Setting out from this knowledge, we wanted, in addition to assessing the beneficent effects of AF on pulmonary tissue, to study the importance of AF in morbidities of this tissue thought to originate from oxygen. …


Does Apocynin Increase Liver Regeneration In The Partial Hepatectomy Model?, Yilmaz Bi̇lgi̇ç, Burhan Hakan Kanat, Onural Özhan, Azi̇be Yildiz, Zeynep Aksungur, Mehmet Erman Erdemli̇, Ni̇gar Vardi, Yusuf Türköz, Ahmet Sami̇ Akbulut, Adem Köse, Hakan Parlakpinar Jan 2023

Does Apocynin Increase Liver Regeneration In The Partial Hepatectomy Model?, Yilmaz Bi̇lgi̇ç, Burhan Hakan Kanat, Onural Özhan, Azi̇be Yildiz, Zeynep Aksungur, Mehmet Erman Erdemli̇, Ni̇gar Vardi, Yusuf Türköz, Ahmet Sami̇ Akbulut, Adem Köse, Hakan Parlakpinar

Turkish Journal of Medical Sciences

Background/aim: Hepayocyte loss may develop secondary to liver surgery and at this point liver regeneration plays a significant act in terms of liver reserve. The purpose of this research was to investigate the efficacy of apocynin on liver regeneration and preservation after partial hepatectomy in rats. Materials and methods: A total of 32 rats, have been divided into 4 groups (n: 8) for hepatectomy model. Inflammatory and antiinflammatory parameters were measured from blood and liver tissue samples. In addition, the effects of apocynin were examined immunohistochemically and histopathologically from liver tissue. Results: In liver tissue samples, a significant difference has …


Curcumin Promotes Skin Wound Healing By Activating Nrf2 Signaling Pathways And Inducing Apoptosis In Mice, Junli Wu, Li Deng, Ling Yin, Zhirong Mao, Xiaoqing Gao Jan 2023

Curcumin Promotes Skin Wound Healing By Activating Nrf2 Signaling Pathways And Inducing Apoptosis In Mice, Junli Wu, Li Deng, Ling Yin, Zhirong Mao, Xiaoqing Gao

Turkish Journal of Medical Sciences

Background/aim: Curcumin may have potential as a therapy for wound healing, but the underlying mechanism remains unclear. It is not known whether curcumin can promote wound healing by activating Nrf2 signaling pathway and inducing apoptosis. This study determined the role of Nrf2 signaling pathway and apoptosis in curcumin-promoting skin wound healing. Materials and methods: The full-thickness skin defect model of mice was made and randomly divided into a control group and a curcumin group. The mice in the curcumin group and in the control group received respectively a daily topical treatment of Vaseline cream with or without 5 mg curcumin. …


The Effects Of Tarantula Cubensis Extract On Renal Ischemia Reperfusion Injury In Rats, Sai̇me Özbek Şebi̇n, Tuncer Nacar, Ayhan Tanyeli̇, Ersen Eraslan, Mustafa Can Güler, Erdem Toktay, Eli̇f Polat, Hati̇ce Tuğçe Gedi̇k Jan 2023

The Effects Of Tarantula Cubensis Extract On Renal Ischemia Reperfusion Injury In Rats, Sai̇me Özbek Şebi̇n, Tuncer Nacar, Ayhan Tanyeli̇, Ersen Eraslan, Mustafa Can Güler, Erdem Toktay, Eli̇f Polat, Hati̇ce Tuğçe Gedi̇k

Turkish Journal of Medical Sciences

Background/aim: Renal ischemia-reperfusion (IR) related acute kidney injury (AKI) is an important health problem and has not yet been fully treated. Tarantula cubensis extract (TCE) is a homeopathic drug that has antiinflammatory and antioxidant effects. This study aimed to investigate the effects of TCE on renal ischemia-reperfusion injury in rats. Materials and methods: This study was carried out on 48 Spraque-Dawley male rats, which were divided into six groups. The first, second, and third groups were control, sham, and IR groups, respectively. Group four received IR and 0.2 mL of 96% ethanol. Group five and six received ischemia and reperfusion …


Association Of Thiol/Disulphide Homeostasis With Bethesda Classification Of Thyroid Nodules And Thyroid Cancer, Muhammet Cüneyt Bi̇lgi̇ner, Abbas Ali̇ Tam, Sevgül Faki, Bağdagül Yüksel Güler, Özcan Erel, İbrahi̇m Kilinç, Di̇dem Özdemi̇r, Oya Topaloğlu, Reyhan Ersoy, Beki̇r Çakir Jan 2022

Association Of Thiol/Disulphide Homeostasis With Bethesda Classification Of Thyroid Nodules And Thyroid Cancer, Muhammet Cüneyt Bi̇lgi̇ner, Abbas Ali̇ Tam, Sevgül Faki, Bağdagül Yüksel Güler, Özcan Erel, İbrahi̇m Kilinç, Di̇dem Özdemi̇r, Oya Topaloğlu, Reyhan Ersoy, Beki̇r Çakir

Turkish Journal of Medical Sciences

Background/aim: Ultrasonography and fine-needle aspiration biopsy are frequently used to diagnose thyroid cancer. However, supportive data might be required in case of diagnostic difficulty. This study investigated whether there is a relationship between thiol/ disulphide homeostasis and cytological and histopathological diagnosis of thyroid nodules. Materials and methods: The patient group consisted of 81 individuals with euthyroid nodular (single/multiple) goiter scheduled for thyroidectomy, and the control group consisted of 28 age- and sex-matched healthy volunteers who had no thyroid nodule on ultrasonographic evaluation. All participants were selected among the admissions to the study clinic between June 2017 and June 2018, and …


What Is The Protective Effect Of Preischemic Kisspeptin-10 Administration Against Ischemia/Reperfusion Injury Of Striatum On Mice?, Hati̇ce Akkaya, Engi̇n Sümer, Seli̇m Kutlu, Hati̇ce Solak, Bayram Yilmaz Jan 2022

What Is The Protective Effect Of Preischemic Kisspeptin-10 Administration Against Ischemia/Reperfusion Injury Of Striatum On Mice?, Hati̇ce Akkaya, Engi̇n Sümer, Seli̇m Kutlu, Hati̇ce Solak, Bayram Yilmaz

Turkish Journal of Medical Sciences

Background/aim: Kisspeptin is a neuropeptide with a primary role on the onset of puberty and has beneficial effects on ischemia/ reperfusion (I/R) injury. In this study, we aimed to investigate the effect of kisspeptin administration on striatal I/R injury in mice. Material and methods: Forty adult C57/BL6 mice were randomly divided into four groups: Sham, Kisspeptin, I/R, and I/R + Kisspeptin groups. The groups were administered with either physiological saline (Sham and I/R groups) or kisspeptin (Kisspeptin and I/R + Kisspeptin groups) intraperitoneally 40 min before the operation. A microdialysis probe was placed in the right striatum according to stereotaxic …


Hidden Threat In Familial Mediterranean Fever: Subclinical Inflammation, Oxidative Stress And Their Relationship With Vitamin D Status, Mhd Boshr Alesh, Di̇dem Barlak Keti̇, Ayşenur Paç Kisaarslan, Sabahatti̇n Muhtaroğlu, Sema Nur Taşkin Jan 2022

Hidden Threat In Familial Mediterranean Fever: Subclinical Inflammation, Oxidative Stress And Their Relationship With Vitamin D Status, Mhd Boshr Alesh, Di̇dem Barlak Keti̇, Ayşenur Paç Kisaarslan, Sabahatti̇n Muhtaroğlu, Sema Nur Taşkin

Turkish Journal of Medical Sciences

Background/aim: Vitamin D levels have been investigated in children with familial Mediterranean fever (FMF), but the relationship between vitamin D status and inflammation/oxidative stress indicators could not be clearly demonstrated. This study aimed to investi- gate the relationship between subclinical inflammation/oxidative stress and vitamin D status in children with FMF during an attack-free period. Materials and methods: In the cross-sectional study, ninety children with FMF in the attack-free period and 30 healthy children were included. Patients were grouped according to their vitamin D status (< 20, 20-29, and 30-100 ng/mL). The groups were compared in terms of pentraxin 3 (PTX-3), total oxidant status (TOS), and total antioxidant status (TAS). Multivariable linear regression analysis was performed to identify factors associated with vitamin D status. Results: PTX-3 levels were significantly higher in patients with vitamin D insufficiency (20-29 ng/mL) than in the group with vitamin D sufficient (30-100 ng/mL). Patients with vitamin D deficiency (< 20 ng/mL) had higher TOS. A strong negative correlation was ob- served between vitamin D levels and TOS (p = 0.003). Subclinical inflammation (PTX-3 ≥ 0.640) and high TOS levels were negatively associated with vitamin D levels. Conclusion: Subclinical inflammation and oxidative stress were negatively associated with vitamin D levels in patients with FMF dur- ing an attack-free period. Sufficient vitamin D levels are important in fighting subclinical inflammation and oxidative stress in children with FMF.


Alpha-Lipoic Acid Prevents Atrial Electrical And Structural Remodeling Via Inhibition Of Nadph Oxidase In A Rabbit Rapid Atrial Pacing Model, Lei Chen, Wen Gao, Yameng Shao, Chenggang Li, Yuan Lu Jan 2022

Alpha-Lipoic Acid Prevents Atrial Electrical And Structural Remodeling Via Inhibition Of Nadph Oxidase In A Rabbit Rapid Atrial Pacing Model, Lei Chen, Wen Gao, Yameng Shao, Chenggang Li, Yuan Lu

Turkish Journal of Medical Sciences

Background/aim: Alpha-lipoic acid (ALA) is a natural compound, one of the natural antioxidants with high activity. In the NADPH oxidase family, NADPH oxidase 4 (NOX4) is an important subunit participating in the production of ROS. NADPH oxidase 2 (NOX2) can form active NADPH oxidase complexes when binding to several other subunits in the cytoplasm, and NOX2 is its major functional subunit. Rapid atrial pacing (RAP) model was constructed to study the effects of ALA on electrical and structural remodeling in rabbits. Materials and methods: Thirty rabbits were divided into SHAM group, RAP group and ALA+RAP group. Their right atriums were …


Clinicoradiological Evaluation Of Oxidative Stress Activity In Acute Cerebral Infarction In The First 24 H And The Qualitative Importance Of Dysfunctional Hdl In Stroke, Esra Demi̇r Ünal, Gönül Vural, Funda Eren, Sali̇m Neşeli̇oğlu, Özcan Erel Jan 2022

Clinicoradiological Evaluation Of Oxidative Stress Activity In Acute Cerebral Infarction In The First 24 H And The Qualitative Importance Of Dysfunctional Hdl In Stroke, Esra Demi̇r Ünal, Gönül Vural, Funda Eren, Sali̇m Neşeli̇oğlu, Özcan Erel

Turkish Journal of Medical Sciences

Background/aim: Acute cerebral infarction (ACI) occurs as a result of instant disruption of vascular flow that causes disbalance between oxidative/antioxidative activity. We examined the relationship of serum neuro-oxidative stress parameters with stroke severity and infarct volume in ACI and emphasized the qualitative importance of high-density lipoprotein (HDL) on its relationship with myeloperoxidase (MPO) and paraoxonase-1 (PON1) in the acute period of stroke. Materials and methods: One hundred ACI patients applied within the first 24 h and 50 healthy volunteers were included. The patient group was evaluated with demographic data (including arrival serum biochemical assessment), clinical disability scores, infarct volume, serum …


Evaluation Of The Relationship Between Vitamin D Level And Adropin, Il-1ss, Il-6, And Oxidative Status In Women, Mehmet Zorlu, Abdüsselam Şekerci̇, Muhammed Tunç, Eray Meti̇n Güler, Bedi̇a Gülen, Cumali̇ Karatoprak, Muharrem Kiskaç, Mustafa Çakirca Jan 2022

Evaluation Of The Relationship Between Vitamin D Level And Adropin, Il-1ss, Il-6, And Oxidative Status In Women, Mehmet Zorlu, Abdüsselam Şekerci̇, Muhammed Tunç, Eray Meti̇n Güler, Bedi̇a Gülen, Cumali̇ Karatoprak, Muharrem Kiskaç, Mustafa Çakirca

Turkish Journal of Medical Sciences

Background/aim: Vitamin D, adropin, proinflammatory cytokines, and oxidative stress closely related with metabolic homeostasis and endothelial dysfunction. The aim of the present study is to investigate how vitamin D levels affect serum adropin, IL-1ß, IL-6, and oxidative stress. Materials and methods: A total of 77 female subjects were divided into 3 groups according to vitamin D levels. Biochemical parameters, adropin, IL-1ß, IL-6, oxidative stress markers were studied in these groups, and the results were compared statistically. Results: Serum adropin, IL-1ß, IL-6, total oxidant status (TOS) and total antioxidant status (TAS) and oxidative stress index (OSI) levels differed significantly between the …


Dynamic Thiol/Disulfide Homeostasis As Oxidative Stress Marker In Diabetic Ketoacidosis, Yavuz Otal, Fati̇h Ahmet Kahraman, Fadi̇me Güllü Haydar, Özcan Erel Jan 2021

Dynamic Thiol/Disulfide Homeostasis As Oxidative Stress Marker In Diabetic Ketoacidosis, Yavuz Otal, Fati̇h Ahmet Kahraman, Fadi̇me Güllü Haydar, Özcan Erel

Turkish Journal of Medical Sciences

Background/aim: The aim of present study was to investigate the dynamic thiol/disulfide homeostasis as oxidative stress marker in diabetic ketoacidosis (DKA). Materials and methods: A total of 77 participants consisting of 32 patients with DKA and 45 healthy volunteers were included in the study. Thiol/disulfide homeostasis (TDH) [total thiol-native thiol/disulfide changes] were measured in both groups (patient group and control group) using a brand new method developed by Erel and Neselioglu. Half of the difference between total thiol and native thiol concentrations gives the amount of disulfide bond. Results: Total thiol, native thiol, and disulfide levels in blood were found …


The Effect Of 1,25-Dihydroxyvitamin D3 On Liver Damage, Oxidative Stress, And Advanced Glycation End Products In Experimental Nonalcoholicand Alcoholic- Fatty Liver Disease, İlknur Bi̇ngül, Abdurrahman Fati̇h Aydin, Canan Küçükgergi̇n, Asi̇ye Işin Doğan Eki̇ci̇, Semra Abbasoğlu, Mehmet Müjdat Uysal Jan 2021

The Effect Of 1,25-Dihydroxyvitamin D3 On Liver Damage, Oxidative Stress, And Advanced Glycation End Products In Experimental Nonalcoholicand Alcoholic- Fatty Liver Disease, İlknur Bi̇ngül, Abdurrahman Fati̇h Aydin, Canan Küçükgergi̇n, Asi̇ye Işin Doğan Eki̇ci̇, Semra Abbasoğlu, Mehmet Müjdat Uysal

Turkish Journal of Medical Sciences

Background/aim: Oxidative stress and advanced glycation end products (AGEs) formation are proposed as effective mechanisms in the pathogenesis of nonalcoholic fatty liver disease (NAFLD) and alcoholic liver disease (ALD). 1,25(OH)2 D3 was proposed to have antioxidant, antiinflammatory and antiglycation properties. In this study, the effect of 1,25(OH)2 D3 treatment on oxidative stress parameters and AGEs levels together with hepatic histopathology was investigated in high fructose (HFr) or ethanol (EtOH)-treated rats. Materials and methods: Rats were treated with fructose (30%) or ethanol (5-20%) in drinking water with and without 1,25(OH)2 D3 treatment (5 µg/kg two times a week) for 8 weeks. …


Dental And Temporomandibular Joint Alterations In Rheumatoid Arthritis Patients Andtheir Association With Salivary Oxidative Stress, Deni̇z Yaman, Duygu Göller Bulut, Gülbahar Ustaoğlu, Emre Avci, Murat Taşçi Jan 2021

Dental And Temporomandibular Joint Alterations In Rheumatoid Arthritis Patients Andtheir Association With Salivary Oxidative Stress, Deni̇z Yaman, Duygu Göller Bulut, Gülbahar Ustaoğlu, Emre Avci, Murat Taşçi

Turkish Journal of Medical Sciences

Background/aim: Rheumatoid arthritis (RA) is the most extensive inflammatory arthritis causing permanent deformities in the joint. Increasing evidence suggests that oxidative stress is a substantial factor in the pathogenesis of RA. This study aimed to examine the salivary oxidant-antioxidant status of RA and control groups and to compare these biomarkers by correlating them with disease activity, acute phase reactants, and clinical findings. Materials and methods: Age and sex-matched 60 participants including 30 patients with RA and 30 control (50 females, 10 males; mean age: 42.62 ± 10.89 years) were evaluated. RA disease activity and severity were evaluated by the disease …


Lutein/Zeaxanthin Isomers Regulate Neurotrophic Factors And Synaptic Plasticity Intrained Rats, Cemal Orhan, Füsun Erten, Beşi̇r Er, Mehmet Tuzcu, Nurhan Şahi̇n, Öznur Ece Durmaz Kurşun, Vijaya Juturu, Kazi̇m Şahi̇n Jan 2021

Lutein/Zeaxanthin Isomers Regulate Neurotrophic Factors And Synaptic Plasticity Intrained Rats, Cemal Orhan, Füsun Erten, Beşi̇r Er, Mehmet Tuzcu, Nurhan Şahi̇n, Öznur Ece Durmaz Kurşun, Vijaya Juturu, Kazi̇m Şahi̇n

Turkish Journal of Medical Sciences

Background/aim: This study was conducted to elucidate the effects of lutein/zeaxanthin isomers (L/Zi) on lipid metabolism, oxidative stress, NF-ΚB/Nrf2 pathways, and synaptic plasticity proteins in trained rats. Materials and methods: Wistar rats were distributed into four groups: 1) control, 2) L/Zi: rats received L/Zi at the dose of 100 mg/kg by oral gavage, 3) exercise, 4) exercise+L/Zi: rats exercised and received L/Zi (100 mg/kg) by oral gavage. The duration of the study was eight weeks. Results: Exercise combined with L/Zi reduced lipid peroxidation and improved antioxidant enzyme activities of muscle and cerebral cortex in rats (p < 0.001). In the Exercise + L/Zi group, muscle and cerebral cortex Nrf2 and HO-1 levels increased, while NF-ΚB levels decreased (p


Thiol/Disulphide Homeostasis In Intensive Care Unit Patients With Sepsis And Septic Shock, Hami̇t Yildiz Jan 2020

Thiol/Disulphide Homeostasis In Intensive Care Unit Patients With Sepsis And Septic Shock, Hami̇t Yildiz

Turkish Journal of Medical Sciences

Background/aim: Sepsis is a condition caused by infection followed by unregulated inflammatory response which may lead to organ dysfunction. The aim of this study is to be the first in the literature and it has been designed to show the thiol/disulphide changes in patients with sepsis and septic shock and their correlation with acute phase reactants. Material and methods: A total of 113 patients (septic shock 53 and sepsis 60) and 60 healthy control subjects have been enrolled in this study from the period February 2018 to 2019. The patients were divided in 2 groups: nonsurvivors (74) and survivors (39). …


Thiol/Disulfide Homeostasis And Ischemia Modified Albumin Levels In Autoimmune Gastritis And Their Relations With Gastric Emptying, Emra Asfuroğlu Kalkan, Serap Boz, Özcan Erel, Sali̇m Neşeli̇oğlu, Çağdaş Kalkan, Ari̇f İrfan Soykan Jan 2020

Thiol/Disulfide Homeostasis And Ischemia Modified Albumin Levels In Autoimmune Gastritis And Their Relations With Gastric Emptying, Emra Asfuroğlu Kalkan, Serap Boz, Özcan Erel, Sali̇m Neşeli̇oğlu, Çağdaş Kalkan, Ari̇f İrfan Soykan

Turkish Journal of Medical Sciences

Background/aim: Autoimmune gastritis is an autoimmune and inflammatory disorder. The aim of this study is to examine dynamic thiol/disulfide homeostasis and ischemia modified albumin levels, and to analyze the association between thiol/disulfide homeostasis and gastric emptying time in autoimmune gastritis. Materials and methods: Thiol/disulfide homeostasis tests and ischemia modified albumin levels were determined in 50 autoimmune gastritis patients and 53 healthy subjects. Patients with delayed and normal gastric emptying were compared by thiol/disulfide homeostasis tests. Results: The results showed that native thiol (μmol/L), total thiol (μmol/L), and native thiol/total thiol ratio (%) of the patients with autoimmune gastritis decreased compared …


Oxidative Stress Parameters In Patients With Ascending Aortic Dilatation, Mehmet Erdoğan, Meli̇ke Polat, Muhammet Ci̇hat Çeli̇k, Selçuk Öztürk, Serdal Baştuğ, Yunus Emre Özbebek, Sali̇m Neşeli̇oğlu, Murat Akçay Jan 2020

Oxidative Stress Parameters In Patients With Ascending Aortic Dilatation, Mehmet Erdoğan, Meli̇ke Polat, Muhammet Ci̇hat Çeli̇k, Selçuk Öztürk, Serdal Baştuğ, Yunus Emre Özbebek, Sali̇m Neşeli̇oğlu, Murat Akçay

Turkish Journal of Medical Sciences

Background/aim: This study aimedto determine plasma thiol, disulphide, and serum ischemia-modified albumin (IMA) levels and ferroxidase activity in patients with ascending aorta dilatation (AAD) in comparison to those without AAD and to evaluate the predictive value of these oxidative stress parameters for AAD.Materials and methods: This study was designed as a cross-sectional study of 184 patients who applied to our cardiology clinic. Our study population consisted of patients with AAD (n = 85) and without AAD (n = 99). A spectrophotometric method was used to determine plasma thiol, disulphide, and serum IMA levels and ferroxidase activity.Results: The native thiol and …


Anakinra, An Interleukin-1 Receptor Antagonist, Increases The Morphine Analgesic Effectand Decreases Morphine Tolerance Development By Modulating Oxidative Stress Andendoplasmic Reticulum Stress In Rats, Onur Avci, Ahmet Şevki̇ Taşkiran Jan 2020

Anakinra, An Interleukin-1 Receptor Antagonist, Increases The Morphine Analgesic Effectand Decreases Morphine Tolerance Development By Modulating Oxidative Stress Andendoplasmic Reticulum Stress In Rats, Onur Avci, Ahmet Şevki̇ Taşkiran

Turkish Journal of Medical Sciences

Background/aim: Recent studies have shown that inflammation plays a role in morphine analgesia and tolerance development. Anakinra is a competitive inhibitor of IL-1 receptors and an antiinflammatory protein regulating IL-1ß's biological activity by avoiding signal transduction. In this study, we aimed to examine the effects of anakinra on morphine analgesia and tolerance. Materials and methods: In this study, 36 Wistar Albino (230-250 g) male rats were used. Animals were divided into 6 groups: saline (S), 100 mg/kg anakinra (A), 5mg/kg morphine (M), M+A, morphine tolerance (MT), and MT+A. The resulting analgesic effect was measured with hot plate and tail-flick analgesia …


Melatonin, Aging, And Covid-19: Could Melatonin Be Beneficial For Covid-19 Treatment In The Elderly?, Güler Öztürk, Kazi̇me Gonca Akbulut, Şevi̇n Güney Jan 2020

Melatonin, Aging, And Covid-19: Could Melatonin Be Beneficial For Covid-19 Treatment In The Elderly?, Güler Öztürk, Kazi̇me Gonca Akbulut, Şevi̇n Güney

Turkish Journal of Medical Sciences

The aim of this review is to summarize current studies on the relationship between melatonin and aging. Nowadays, age-related diseases come into prominence, and identifying age-related changes and developing proper therapeutic approaches are counted as some of the major issues regarding community health. Melatonin is the main hormone of the pineal gland. Melatonin is known to influence many biological processes in the body, including circadian rhythms, the immune system, and neuroendocrine and cardiovascular functions. Melatonin rhythms also reflect the biological process of aging. Aging is an extremely complex and multifactorial process. Melatonin levels decline considerably with aging and its decline …


The Effect Of Hyperglycemic Peak Induced By Oral Glucose Tolerance Test On The Oxidant And Antioxidant Levels, Teki̇n Yildirim, Ayşe Yeşi̇m Göçmen, Zeynep Tuğba Özdemi̇r, Eli̇f Börekci̇, Eli̇f Turan, Yalçin Aral Jan 2019

The Effect Of Hyperglycemic Peak Induced By Oral Glucose Tolerance Test On The Oxidant And Antioxidant Levels, Teki̇n Yildirim, Ayşe Yeşi̇m Göçmen, Zeynep Tuğba Özdemi̇r, Eli̇f Börekci̇, Eli̇f Turan, Yalçin Aral

Turkish Journal of Medical Sciences

Background/aim: The possibility of adverse effects of the oral glucose tolerance test (OGTT) carried out for the screening of gestational diabetes among pregnant women and fetuses is a frequently discussed topic. The purpose of this study was to investigate the effects of the hyperglycemia peak during OGTT on the levels of oxidants and antioxidants in the body.Materials and methods: Eighty individuals who applied to the Outpatient Clinic with suspected diabetes and OGTT indication were included in the study. Glucose, total oxidant capacity status (TOS), total antioxidant capacity (TAS), superoxide dismutase (SOD), and lipid hydroperoxide (LOOH) levels were tested on blood …


Can Apelin Play A Role In The Etiology Of Tinnitus?, Nuray Ensari̇, Özer Erdem Gür, Ni̇lgün Gür, Ömer Tarik Selçuk, Levent Renda, Mustafa Deni̇z Yilmaz, Mehmet Türker Öztürk, Yeşi̇m Çeki̇n Jan 2019

Can Apelin Play A Role In The Etiology Of Tinnitus?, Nuray Ensari̇, Özer Erdem Gür, Ni̇lgün Gür, Ömer Tarik Selçuk, Levent Renda, Mustafa Deni̇z Yilmaz, Mehmet Türker Öztürk, Yeşi̇m Çeki̇n

Turkish Journal of Medical Sciences

Background/aim: Tinnitus is seen in 15% of the general population; in 1%-6% of this number, the quality of life is seriously affected by this chronic condition. Chemical, oxidative, and emotional stressors are important in terms of the clinical course of tinnitus. Apelin is an endogenous peptide which is an oxidative stress mediator. It has been shown that the apelin/APJ (apelin junction receptor) system plays various roles in the physiology and pathophysiology of many organs. However, the role of the apelin/APJ system as an oxidative stress mediator in tinnitus is unknown. We investigated the level of apelin in patients with normal …


The Effect Of N-Acetylcysteine On Inflammation And Oxidative Stress In Cisplatin-Induced Nephrotoxicity: A Rat Model, İnayet Güntürk, Cevat Yazici, Sema Kader Köse, Fatma Dağli, Bi̇lal Yücel, Arzu Hanim Yay Jan 2019

The Effect Of N-Acetylcysteine On Inflammation And Oxidative Stress In Cisplatin-Induced Nephrotoxicity: A Rat Model, İnayet Güntürk, Cevat Yazici, Sema Kader Köse, Fatma Dağli, Bi̇lal Yücel, Arzu Hanim Yay

Turkish Journal of Medical Sciences

Background/Aim: Cisplatin is a highly effective chemotherapeutic agent used in the treatment of solid organ cancers. Besides its chemotherapeutic effectiveness, cisplatin administration is associated with numerous side effects. Of those, the most clinically significant and common effect is nephrotoxicity. Recent studies reported that oxidative stress and inflammation are probably the most important mechanisms that contribute to the nephrotoxicity. N-acetylcysteine (NAC) is an antioxidant and antiinflammatory agent. In the present study, the effects of NAC on cisplatin-induced nephrotoxicity were investigated. Materials and methods: Rats were divided into four groups each including eight rats: CONT, NAC-250, CP, and CP+NAC. Rats in experimental …


8-Hydroxy-2'-Deoxyguanosine As A Biomarker Of Oxidative Stress In Acute Exacerbation Of Chronic Obstructive Pulmonary Disease, Xing Liu, Kaili Deng, Sixia Chen, Yunshi Zhang, Jing Yao, Xiaoqin Weng, Yang Zhang, Tianming Gao, Ganzhu Feng Jan 2019

8-Hydroxy-2'-Deoxyguanosine As A Biomarker Of Oxidative Stress In Acute Exacerbation Of Chronic Obstructive Pulmonary Disease, Xing Liu, Kaili Deng, Sixia Chen, Yunshi Zhang, Jing Yao, Xiaoqin Weng, Yang Zhang, Tianming Gao, Ganzhu Feng

Turkish Journal of Medical Sciences

8-Hydroxy-2'-deoxyguanosine (8-OHdG) is a biomarker of oxidative stress and has been implicated in many diseases. The aim of this study was to investigate the clinical value of plasma 8-OHdG level in patients with acute exacerbation of chronic obstructive pulmonary disease (AECOPD).Materials and methods: A total of 154 subjects were enrolled in this study, including 20 healthy volunteers, 24 COPD patients in the stable phase, and 110 AECOPD patients. Peripheral blood samples, demographic information, and clinical characteristics were collected from all subjects at the time of being recruited into the study. Plasma 8-OHdG level was detected by enzyme-linked immunosorbent assay.Results: 8-OHdG …


Ischemic Modified Albumin As A New Biomarker In Predicting Oxidative Stress In Alopecia Areata, Hati̇ce Ataş, Müzeyyen Gönül, Yasi̇n Öztürk, Mustafa Kavutçu Jan 2019

Ischemic Modified Albumin As A New Biomarker In Predicting Oxidative Stress In Alopecia Areata, Hati̇ce Ataş, Müzeyyen Gönül, Yasi̇n Öztürk, Mustafa Kavutçu

Turkish Journal of Medical Sciences

Results show that oxidative stress is a pathophysiologic factor for alopecia areata (AA); however, the markers used can be confounding. Thus, we aimed to investigate the role of oxidative stress in the pathogenesis of AA through an evaluation of ischemia-modified albumin (IMA); other markers of the oxidant/antioxidant system, such as SOD, CAT, GSH-ST, and MDA; and contributing clinical risk factors. Materials and methods: The usefulness of IMA as a new marker for oxidative stress was compared with that of other markers and evaluated in patients with AA.Results: The mean serum level of IMA was of higher statistical significance in AA …


Additional Effects Of Erythropoietin Pretreatment, Ischemic Preconditioning, And N-Acetylcysteine Posttreatment In Rat Kidney Reperfusion Injury, Mohammed Elshiekh, Mehri Kadkhodaee, Behjat Seifi, Mina Ranjbaran Jan 2019

Additional Effects Of Erythropoietin Pretreatment, Ischemic Preconditioning, And N-Acetylcysteine Posttreatment In Rat Kidney Reperfusion Injury, Mohammed Elshiekh, Mehri Kadkhodaee, Behjat Seifi, Mina Ranjbaran

Turkish Journal of Medical Sciences

Background/aim: Since the nature of ischemia/reperfusion (IR)-induced tissue damage is multifactorial and complex, in the current study, the effects of multiple treatment strategies via concomitant administration of erythropoietin (EPO) and N-acetylcysteine (NAC) with an ischemic preconditioning (IPC) regimen on renal IR injury were examined.Materials and methods: Thirty male Wistar rats were subjected to bilateral occlusion of the renal pedicles for 50 min followed by reperfusion. EPO (1000 IU/kg) was administered for 3 days, as well as IPC before the IR and NAC (150 mg/kg) administration for 4 days after IR. The animals were randomly allocated into 6 groups (n = …