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Elderly And Aged Asthma Have Different Characteristics: Results Of A Multicenter Study, Ebru Damadoğlu, Özge Öztürk Aktaş, Bilun Gemi̇ci̇oğlu, Nafiye Yilmaz, Fulşen Bozkuş, Vehbi Ayhan, Ayşe Füsun Kalpaklioğlu, Ferda Öner Erkekol, Yavuz Havlucu, Fuat Erel, Ömür Aydin, Aydanur Eki̇ci̇, Ayşe Baççioğlu, Serap Argun Bariş, Gözde Köycü Buhari̇, Berrin Ceyhan, Özlem Göksel, Mehmet Köse, Adile Berna Dursun, Füsun Yildiz, Arzu Yorgancioğlu, Sacide Rana Işik, Dane Edi̇ger, İpek Kıvılcım Oğuzülgen, Ahmet Uğur Demi̇r, Gül Karakaya, Ali Fuat Kalyoncu Jan 2024

Elderly And Aged Asthma Have Different Characteristics: Results Of A Multicenter Study, Ebru Damadoğlu, Özge Öztürk Aktaş, Bilun Gemi̇ci̇oğlu, Nafiye Yilmaz, Fulşen Bozkuş, Vehbi Ayhan, Ayşe Füsun Kalpaklioğlu, Ferda Öner Erkekol, Yavuz Havlucu, Fuat Erel, Ömür Aydin, Aydanur Eki̇ci̇, Ayşe Baççioğlu, Serap Argun Bariş, Gözde Köycü Buhari̇, Berrin Ceyhan, Özlem Göksel, Mehmet Köse, Adile Berna Dursun, Füsun Yildiz, Arzu Yorgancioğlu, Sacide Rana Işik, Dane Edi̇ger, İpek Kıvılcım Oğuzülgen, Ahmet Uğur Demi̇r, Gül Karakaya, Ali Fuat Kalyoncu

Turkish Journal of Medical Sciences

Characteristics of asthma in the elderly population is not well-known. The aim of the present study was to evaluateasthma in the elderly population, to compare disease characteristics between patients diagnosed <60 (aged asthma) and ≥60 (elderlyasthma) years of age.Materials and methods: The study was a prospective, multicenter, cross-sectional type. A questionnaire was filled out to patients 60years of age and over, that have been followed for asthma for at least 3 months. Asthma Control Test (ACT), eight-item MoriskyMedication Adherence Scale (MMAS-8) was filled out, inhaler device technique was assessed.Results: A total of 399 patients were included from 17 tertiary care centers across the country. Mean age was 67.11 years and 331 (83%)were female. The age at asthma diagnosis was ≥60 in 146 (36.6%) patients. Patients diagnosed ≥60 years were older (p < 0.001), hadhigher education level (p < 0.001), more commonly had first-degree relative with asthma (p = 0.038), asthma related comorbidities(p = 0.009) and accompanying rhinitis/rhinosinusitis (p = 0.005), had better asthma control (p = 0.001), were using less controllermedications (p = 0.014). Inhaler technique was correct in 37% of the patients with no difference in between the groups. Treatmentcompliance was better in elderly asthma patients (p < 0.001). In the multivariate logistic regression analysis, having well-controlledasthma (odds ratio = 1.61, CI = 1.04–2.51), and high medication adherence rate (odds ratio = 2.43, CI = 1.48–4.0) were associated withbeing in the elderly asthma group.Conclusion: The characteristics of asthma are different among patients aged 60 years and over which seems to be related to onset age ofasthma. In our cohort, the elderly asthma patients had higher education level, and treatment adherence and asthma control was better.Patients diagnosed ≥60 years of age did not have more severe disease.


Evaluation Of Accompanying Allergic Disease In Children With Proven Drug Allergies, Şule Büyük Yaytokgi̇l, Kezban İpek Demi̇r, Özge Yılmaz Topal, Azize Pınar Metbulut, İlknur Külhaş Çeli̇k, Müge Toyran, Ersoy Ci̇velek, Emine Di̇bek Misirlioğlu Jan 2024

Evaluation Of Accompanying Allergic Disease In Children With Proven Drug Allergies, Şule Büyük Yaytokgi̇l, Kezban İpek Demi̇r, Özge Yılmaz Topal, Azize Pınar Metbulut, İlknur Külhaş Çeli̇k, Müge Toyran, Ersoy Ci̇velek, Emine Di̇bek Misirlioğlu

Turkish Journal of Medical Sciences

Data on the prevalence of allergic diseases in children with proven drug allergies are limited. We aim to evaluate thefrequency of allergic comorbidity in children with proven common drug allergies.Materials and methods: Children with drug hypersensitivity confirmed by diagnostic allergy tests at our center between January 2010and December 2020 were screened retrospectively. Patients with the most common drug allergies (due to antibiotics, nonsteroidalantiinflammatory drugs [NSAIDs], and antiepileptic drugs) were selected for analysis. Age, sex, the culprit drug, initial reactioncharacteristics, diagnostic test results, and the study physician who diagnosed concomitant allergic diseases were noted.Results: A total of 168 patients (boys, 51.2%) …


Determination Of The Effects Of Advanced Glycation End Products Receptor Polymorphisms And Its Activation On Structural Cell Responses And Inflammation In Asthma, Esra Bi̇rben, Ümi̇t Murat Şahi̇ner, Can Ömer Kalayci Jan 2023

Determination Of The Effects Of Advanced Glycation End Products Receptor Polymorphisms And Its Activation On Structural Cell Responses And Inflammation In Asthma, Esra Bi̇rben, Ümi̇t Murat Şahi̇ner, Can Ömer Kalayci

Turkish Journal of Medical Sciences

Background/aim: Advanced glycation end products receptor (RAGE) is a pattern recognition receptor which attracted attention in chronic airway diseases recently. This study aimed to determine the association of RAGE with asthma and the cellular responses resulting from RAGE signaling pathway activation. Materials and methods: Asthmatic (n = 362) and healthy (n = 134) children were genotyped by PCR-RFLP. Plasma sRAGE levels were determined by ELISA. Lung structural cells were stimulated with AGEs (advanced glycation end products) and control BSA. Expressions of cytokines and protein levels were determined by real-time PCR and ELISA. Results: Gly82Ser and -374 T/A polymorphisms in RAGE …


Characteristics Of Children With Cat Sensitivity: A Prospective Cross-Sectional Study, Ezgi̇ Ulusoy Severcan, Nevzat Başkaya, Ayşegül Ertuğrul, Zeynep Şengül Emeksi̇z, İlknur Bostanci Jan 2023

Characteristics Of Children With Cat Sensitivity: A Prospective Cross-Sectional Study, Ezgi̇ Ulusoy Severcan, Nevzat Başkaya, Ayşegül Ertuğrul, Zeynep Şengül Emeksi̇z, İlknur Bostanci

Turkish Journal of Medical Sciences

Background/aim: Animal dander is one of the most common respiratory allergens in children, and there is evidence that cat sensitivity is a risk factor for asthma and allergic rhinitis. In this study, it was aimed to evaluate children with cat sensitivity and to identify their demographic and clinical characteristics. Materials and methods: Patients who were found to be sensitive to cats following skin prick tests performed in our allergy clinic over a period of one year (and two control groups), were included in the study. Patients in the study and control groups filled in a questionnaire including demographic and clinical …


Long-Term Efficiency Of Pulmonary Rehabilitation In Patients With Chronic Obstructive Pulmonary Disease, Bronchiectasis, And Asthma: Does It Differ?, Mustafa Engi̇n Şahi̇n, Seher Satar, Pinar Ergün Jan 2023

Long-Term Efficiency Of Pulmonary Rehabilitation In Patients With Chronic Obstructive Pulmonary Disease, Bronchiectasis, And Asthma: Does It Differ?, Mustafa Engi̇n Şahi̇n, Seher Satar, Pinar Ergün

Turkish Journal of Medical Sciences

Background and aim: The long-term effects of pulmonary rehabilitation (PR) and maintenance programs in obstructive pulmonary diseases have not been sufficiently investigated, particularly in diseases other than COPD. This retrospective study aimed to examine the long-term results of individualized comprehensive outpatient pulmonary rehabilitation in patients with obstructive pulmonary disease. Materials and methods: This study is a single-center, retrospective cohort study. Between 2010 and 2019, 269 patients with chronic airway obstruction were treated in our multidisciplinary PR center at a tertiary training and research hospital, and they were divided into three groups based on their diagnosis: COPD, bronchiectasis, and asthma. Patients' …


Can Development Of Asthma And Bronchial Hyperreactivity Be Reduced By Subcutaneous Immunotherapy In Adult Patients With Allergic Rhinitis?, Fatma Merve Tepetam, Ci̇han Örçen, Zeynep Ferhan Özşeker, Di̇ldar Duman, Sema Saraç Jan 2023

Can Development Of Asthma And Bronchial Hyperreactivity Be Reduced By Subcutaneous Immunotherapy In Adult Patients With Allergic Rhinitis?, Fatma Merve Tepetam, Ci̇han Örçen, Zeynep Ferhan Özşeker, Di̇ldar Duman, Sema Saraç

Turkish Journal of Medical Sciences

Background/aim: Allergic rhinitis can be associated with bronchial hyperreactivity (BHR) and create an increased risk for allergic asthma development. We aimed to investigate the effects of subcutaneous immunotherapy (SCIT) on BHR and asthma development in adult patients with allergic rhinitis. Material and methods: The retrospective case-control study was carried out between November 2018 and May 2019 in Süreyyapaşa Chest Diseases and Thoracic Surgery Training and Research Hospital. In this study, data was recorded for patients with a mite and/or grasses/cereals pollen allergy who were tested for BHR before planned SCIT, and who had allergic rhinitis, with or without asthma. The …


Frequency Of Peripheral Blood Eosinophilia And Obstructive Airway Disease In Sarcoidosis, Bi̇lal Rabahoğlu, Fatma Sema Oymak, Burcu Baran Ketenci̇oğlu, Nuri̇ Tutar, İnci̇ Gülmez, İnsu Yilmaz Jan 2021

Frequency Of Peripheral Blood Eosinophilia And Obstructive Airway Disease In Sarcoidosis, Bi̇lal Rabahoğlu, Fatma Sema Oymak, Burcu Baran Ketenci̇oğlu, Nuri̇ Tutar, İnci̇ Gülmez, İnsu Yilmaz

Turkish Journal of Medical Sciences

Background/aim: There is limited information about peripheral blood eosinophilia (PBE) and airway obstruction in sarcoidosis. Since pulmonary sarcoidosis affects the airways, it is often confused with asthma. The aims of the study are to investigate airway obstruction and PBE in sarcoidosis patients and to examine the similarity of clinical presentation with asthma. Materials and methods: The patients matching the ATS/ERS/WASOG diagnosis criteria and were between 18 and 80 years of age were included consecutively between 2018 and 2020. Other diseases causing granulomas were excluded. Results: A total of 84 patients were included of which 26 (31%) had a PBE level …


Allergic Bronchopulmonary Aspergillosis In Children, Özge Atay, Suna Asi̇lsoy, Gi̇zem Atakul, Serdar Al, Özge Kangalli Boyacioğlu, Nevi̇n Uzuner, Özkan Karaman Jan 2021

Allergic Bronchopulmonary Aspergillosis In Children, Özge Atay, Suna Asi̇lsoy, Gi̇zem Atakul, Serdar Al, Özge Kangalli Boyacioğlu, Nevi̇n Uzuner, Özkan Karaman

Turkish Journal of Medical Sciences

Background/aim: Allergic bronchopulmonary aspergillus (ABPA) is a lung disease caused by hypersensitivity from Aspergillus fumigatus. Diagnostic criteria, staging systems and treatment methods for ABPA disease have been reported in studies evaluating populations, the majority of which are adult patients. Our study aimed to discuss the use of ABPA diagnostic criteria in children, the success of other alternative regimens to oral corticosteroids in the treatment of ABPA, and the changes that occur during treatment, in the light of the literature. Materials and methods: Between January 2017 and 2020, patients diagnosed with ABPA at the Dokuz Eylül University Child Allergy and Immunology …


Trends Of Sensitization To Aeroallergens In Patients With Allergic Rhinitis And Asthma Inthe City Of Bursa, South Marmara Sea Region Of Turkey, Dane Edi̇ger, Fatma Esra Günaydin, Müge Erbay, Ümmühan Şeker Jan 2020

Trends Of Sensitization To Aeroallergens In Patients With Allergic Rhinitis And Asthma Inthe City Of Bursa, South Marmara Sea Region Of Turkey, Dane Edi̇ger, Fatma Esra Günaydin, Müge Erbay, Ümmühan Şeker

Turkish Journal of Medical Sciences

Background/aim: Allergic rhinitis (AR) and asthma are the most common allergic disorders worldwide. Aeroallergens are critical causative factors in the pathogenesis of these disorders and sensitization to aeroallergens differs in various countries and regions. Identification of the most common aeroallergen sensitization is crucial in the diagnosis and management of AR and asthma. We examined the distribution of aeroallergen sensitizations detected by skin prick tests (SPTs) in adult patients with AR and/or asthma in the city of Bursa. Materials and methods: Five hundred forty-five patients who underwent a SPT and were diagnosed with rhinitis and/or asthma in the Uludağ University Faculty …


Seasonal, Sex Variations In Vitamin D Levels And Their Association With Pulmonary Function In Children With Asthma, Şebnem Özdoğan Jan 2019

Seasonal, Sex Variations In Vitamin D Levels And Their Association With Pulmonary Function In Children With Asthma, Şebnem Özdoğan

Turkish Journal of Medical Sciences

Background/aim: We aimed to examine the seasonal and sex variations in vitamin D levels in children with asthma and their associations with lung function. Materials and methods: We conducted a cohort study involving children aged 7?17 years old with asthma. Vitamin D levels were obtained and pulmonary function tests (PFTs) were performed in winter months (December, January, and February) and at the end of summer (August, September, and October). Seasonal and sex variations in vitamin D levels and lung function were examined. Results: A total of 56 children (26 males, mean age: 11.93 ± 1.8) were enrolled. The mean vitamin …


Mesh Nebulizer Is As Effective As Jet Nebulizer In Clinical Practice Of Acute Asthma In Children, Özge Uysal Soyer, Meli̇ke Kahveci̇, Ayşe Betül Büyükti̇ryaki̇, Ebru Arik Yilmaz, Betül Karaatmaca, Sali̇ha Esenboğa, Pinar Gür Çeti̇nkaya, Ümi̇t Murat Şahi̇ner, Bülent Eni̇s Şekerel Jan 2019

Mesh Nebulizer Is As Effective As Jet Nebulizer In Clinical Practice Of Acute Asthma In Children, Özge Uysal Soyer, Meli̇ke Kahveci̇, Ayşe Betül Büyükti̇ryaki̇, Ebru Arik Yilmaz, Betül Karaatmaca, Sali̇ha Esenboğa, Pinar Gür Çeti̇nkaya, Ümi̇t Murat Şahi̇ner, Bülent Eni̇s Şekerel

Turkish Journal of Medical Sciences

Background/aim: The aim of this study was to compare the effect of salbutamol delivered to children by jet nebulizer (JN) and mesh nebulizer (MN). Materials and methods: Children admitted with acute asthma were treated with 3 doses of nebulized salbutamol, 1 given by MN. The patients' vital signs, lung function measurements, modified pulmonary index score (MPIS), and whole body plethysmography (WBP) measurements were evaluated before and 20 min after each dose of salbutamol.Results: Thirty-onechildren [9.5 (6.4-17.2) years, 67.7% male, 32.3% female] with mild (67.7%) and moderate (32.3%) asthma attacks were included in the study. The improvements with MN were comparable …


Significant Association Between Scgb1d4 Gene Polymorphisms And Susceptibility To Adenoid Hypertrophy In A Pediatric Population, Tali̇h Özdaş, Si̇bel Özdaş, Mehmet Ali̇ Babademez, Sami̇ Engi̇n Muz, Mahmut Huntürk Ati̇lla, Si̇bel Başti̇mur, Afi̇fe İzbirak, Kenan Kurt, Işilay Öz Jan 2017

Significant Association Between Scgb1d4 Gene Polymorphisms And Susceptibility To Adenoid Hypertrophy In A Pediatric Population, Tali̇h Özdaş, Si̇bel Özdaş, Mehmet Ali̇ Babademez, Sami̇ Engi̇n Muz, Mahmut Huntürk Ati̇lla, Si̇bel Başti̇mur, Afi̇fe İzbirak, Kenan Kurt, Işilay Öz

Turkish Journal of Medical Sciences

Background/aim: Adenoid hypertrophy (AH) is chronic enlargement of the adenoid tissue. The pathophysiology of the disease is unclear. We analyzed SCGB1D4 gene polymorphisms in order to determine the effect of the variants or their genetic combinations on AH. Materials and methods: We genotyped the SCGB1D4 (IIS) gene in 167 participants (95 children with AH and 72 controls) by performing DNA sequencing in blood samples. Results: We genotyped three single nucleotide polymorphisms (SNPs). In the analysis, we found that in the presence of those SNPs and the minor alleles of individual SNPs four haplotypes were associated with an increased risk of …


Risk Factors And Prognosis In Children Hospitalized Due To Pandemic H1n1 Influenza A Virus Infection In Ankara, Turkey*, Medi̇ne Ayşi̇n Taşar, Yildiz Bi̇lge, Özge Uysal Soyer, Şükran Yildirim, Mustafa Taşar, Fatma İnci̇ Arikan Jan 2012

Risk Factors And Prognosis In Children Hospitalized Due To Pandemic H1n1 Influenza A Virus Infection In Ankara, Turkey*, Medi̇ne Ayşi̇n Taşar, Yildiz Bi̇lge, Özge Uysal Soyer, Şükran Yildirim, Mustafa Taşar, Fatma İnci̇ Arikan

Turkish Journal of Medical Sciences

To describe the demographic characteristics and clinical features in children with influenza A (H1N1) virus infection and to identify risk factors for severe disease or poor prognosis. Following the first tourist-imported case in Turkey on 16 May 2009, the influenza A (H1N1) virus has spread throughout the country. Materials and methods: Children under 18 years of age who were hospitalized for at least 24 h with an influenza-like illness and who had confirmed influenza A (H1N1) virus infection were included in the study. Demographic factors, clinical signs and symptoms, laboratory results, radiographic findings, treatments, and follow-up periods were noted. Results: …


Is The Six-Minute Walk Test Correlated With Disease Control And Quality Of Life In Children With Asthma?, Hasan Yüksel, Özge Yilmaz, Bülent Gökşen, Senem Üstün, Ayhan Söğüt Jan 2012

Is The Six-Minute Walk Test Correlated With Disease Control And Quality Of Life In Children With Asthma?, Hasan Yüksel, Özge Yilmaz, Bülent Gökşen, Senem Üstün, Ayhan Söğüt

Turkish Journal of Medical Sciences

To evaluate the changes in a 6-min walk test (6MWT) and quality of life (QoL) before and after asthma control is achieved in children. A 6MWT is used in the determination of disease severity in many chronic childhood diseases. Materials and methods: Thirty-six asthmatic children, aged 6 to 15 years, were enrolled before asthma control was achieved. Disease severity parameters during the previous 3 months were recorded. All of the children completed an asthma control questionnaire (ACQ) and received a symptom score; a 6MWT was performed during enrollment and 1 month later, when asthma control was achieved. Results: The initial …


Effects Of L-2-Oxоthiazolidine-4-Carboxylic Acid On The Lung Antioxidant Defense System In An Asthma Mouse Model, Lyudmil Georgiev Terziev, Veneta Lyubenova Shopova, Violeta Yordanova Dancheva, Galya Tzvetanova Stavreva, Angelina Milcheva Stoyanova Jan 2012

Effects Of L-2-Oxоthiazolidine-4-Carboxylic Acid On The Lung Antioxidant Defense System In An Asthma Mouse Model, Lyudmil Georgiev Terziev, Veneta Lyubenova Shopova, Violeta Yordanova Dancheva, Galya Tzvetanova Stavreva, Angelina Milcheva Stoyanova

Turkish Journal of Medical Sciences

We aim ed to study the effect of a glutathione precursor, L-2-oxothiazolidine-4-carboxylic acid (OTCA), on the lung antioxidant defense system in an animal asthma model. Materials and methods: The study was carried out on 24 female C57BL/6 mice. The mice were divided into 4 treatment groups: group 1 - control group; group 2 - injected with ovalbumin (OVA) and given an OVA inhalant; group 3 - treated with OTCA and phosphate-buffered saline inhalant; and group 4 -injected with OVA and OTCA and given an OVA inhalant. Under sodium pentobarbital anesthesia the animals were killed by exsanguination 48 h after the …


Objective And Subjective Effects Of Surgical Treatment Of Nasal Obstructions In Patients With Asthma, Hali̇l Erdem Özel, Özer Erdem Gür, Serpi̇l Arikan, Cafer Özdem Jan 2011

Objective And Subjective Effects Of Surgical Treatment Of Nasal Obstructions In Patients With Asthma, Hali̇l Erdem Özel, Özer Erdem Gür, Serpi̇l Arikan, Cafer Özdem

Turkish Journal of Medical Sciences

There is a lot of evidence indicating an association between upper and lower airway diseases. The objective of this study was to investigate the objective and subjective effects of surgical treatment of pathologies causing nasal obstruction in relation with asthma. Materials and methods: In this study, 17 patients with asthma were divided into 2 groups. Nine patients with septal and/or disorders of turbinate constituted group 1, and 8 patients with nasal polyposis or concomitant septal deviation constituted group 2. Nasal endoscopic examination was performed and paranasal sinus computed tomography was obtained for each patient. Subjects with nasal polyposis, refractory to …


The Prevalence Of Asthma, Allergic Rhinitis, And Eczema Among Middle School Students In Tabriz (Northwestern Iran), Leyla Sahebi, Mahnaz Sadeghi Shabestary Jan 2011

The Prevalence Of Asthma, Allergic Rhinitis, And Eczema Among Middle School Students In Tabriz (Northwestern Iran), Leyla Sahebi, Mahnaz Sadeghi Shabestary

Turkish Journal of Medical Sciences

To investigate the prevalence of atopic syndrome and the associated risk factors among middle school students. Asthma, allergic rhinitis, and eczema have an extensive epidemiologic diversity in various geographic areas. Materials and methods: This cross-sectional study was performed on 1508 students in the city of Tabriz (a northwestern Turkish-populated region of Iran) in 2009. The International Study of Asthma and Allergies in Childhood questionnaire was used to collect data. The collected data was analyzed using SPSS 16. Results: The prevalence of cumulative and periodic wheezing and diagnosed asthma was 3.7%, 2.9%, and 2%, respectively. The diagnosed prevalence of cumulative and …


Evaluation Of Oxidant/Antioxidant Status And Ecp Levels In Asthma, Ömer Emecen, Berri̇n Berçi̇k İnal, Füsun Erdenen, Murat Usta, Hale Aral, Güvenç Güvenen Jan 2010

Evaluation Of Oxidant/Antioxidant Status And Ecp Levels In Asthma, Ömer Emecen, Berri̇n Berçi̇k İnal, Füsun Erdenen, Murat Usta, Hale Aral, Güvenç Güvenen

Turkish Journal of Medical Sciences

Inflammatory and immune cells, such as eosinophils, macrophages, and neutrophils, generate more reactive oxygen species in patients with asthma than they do in healthy individuals, and oxygen radicals contribute to tissue injury in asthma. We aimed to measure total oxidant status (TOS) and antioxidant status (TAS) in order to assess oxidative and antioxidative capacity. Eosinophil cationic protein (ECP), total IgE, and eosinophils (%) were measured to evaluate the level of inflammation. Materials and methods: The study included 56 non-smoking asthma patients that were followed-up at the respiratory disease and allergy outpatient clinics, where they received ongoing treatment for 5 months …


Peripheral Blood Lymphocyte Activation And Rantes Levels In Asthma, Gaye Erten, Benan Müselli̇m, Bülent Tutluoğlu, Bi̇lun Gemi̇ci̇oğlu, Günnur Deni̇z Jan 2008

Peripheral Blood Lymphocyte Activation And Rantes Levels In Asthma, Gaye Erten, Benan Müselli̇m, Bülent Tutluoğlu, Bi̇lun Gemi̇ci̇oğlu, Günnur Deni̇z

Turkish Journal of Medical Sciences

Aim: Bronchial mucosal inflammation is one of the major characteristics of atopic asthma. Th2 activation and the related cytokine profile, eosinophil activation and infiltration play the main role in the pathogenesis of atopic asthma. The aim of this study was to demonstrate the activation and RANTES (regulated on activation, normal T-cell expressed and presumably secreted) expression of peripheral blood lymphocytes of non-atopic and atopic asthmatic patients. Materials and Methods: CD3, CD4, CD8, CD16, CD23, CD25, CD45RA and CD45RO expressions were determined in 22 asthma patients and 20 healthy control subjects by flow cytometry, and RANTES levels were measured by ELISA. …


Serum Transforming Growth Factor-Β (Tgf-Β), Matrix Metalloproteinase-2 (Mmp-2), Matrix Metalloproteinase-9 (Mmp-9) And Tissue Inhibitors Of Metalloproteinase (Timp-1) Levels In Childhood Asthma, Fi̇gen Doğu, Ali̇şan Yildiran, Deni̇z Güloğlu, Funda Erol Çi̇pe, Mutlu Yüksek, Emel Babacan, Aydan İki̇nci̇oğullari Jan 2008

Serum Transforming Growth Factor-Β (Tgf-Β), Matrix Metalloproteinase-2 (Mmp-2), Matrix Metalloproteinase-9 (Mmp-9) And Tissue Inhibitors Of Metalloproteinase (Timp-1) Levels In Childhood Asthma, Fi̇gen Doğu, Ali̇şan Yildiran, Deni̇z Güloğlu, Funda Erol Çi̇pe, Mutlu Yüksek, Emel Babacan, Aydan İki̇nci̇oğullari

Turkish Journal of Medical Sciences

Aims: Airway remodelling is a characteristic feature of asthma and is a dynamic process involving extracellular matrix (ECM) production and its degradation. In this regard, the matrix metalloproteinases (MMPs) and their specific inhibitors known as tissue inhibitors of metalloproteinases (TIMPs) have been shown to be important in this process. In the present study, transforming growth factor (TGF)-\beta, MMP-2, MMP-9 and TIMP-1 levels in serum samples of children with stable asthma and healthy controls were evaluated to determine whether these levels show any difference between asthmatic and healthy children and whether or not these levels change with atopic status. Materials and …


Effect Of Montelukast Treatment On Serum Paraoxonase Activity In Asthmatic Children, Murat Can, A. Görkem Mungan, Şerefden Açikgöz, Bi̇rol Yüksel, Selda Demi̇rtaş, Nazan Tomaç Jan 2007

Effect Of Montelukast Treatment On Serum Paraoxonase Activity In Asthmatic Children, Murat Can, A. Görkem Mungan, Şerefden Açikgöz, Bi̇rol Yüksel, Selda Demi̇rtaş, Nazan Tomaç

Turkish Journal of Medical Sciences

Montelukast, widely used in the treatment of asthma, is a selective and potent oral cysteinyl leukotriene-1 receptor antagonist. In this study, we investigated the effects of montelukast on oxidative stress and antioxidant defense in childhood asthma by measuring malondialdehyde and the paraoxonase activity. Twenty-five children with mild to moderate atopic asthma and 25 nonatopic children as controls were enrolled in the study. Asthmatic children were treated with montelukast, 5 mg tablets, for one month. Serum paraoxonase, malondialdehyde and high-density lipoprotein (HDL) cholesterol levels were measured before and after treatment. Serum paraoxonase and paraoxonase/HDL ratios were significantly increased after montelukast treatment. …


Evaluation Of Tumor Markers In Asthma Patients, Abdurrahman Coşkun, Öner Balbay, Özlem Yavuz, Ramazan Memi̇şoğullari, Ali̇ Ni̇hat Annakkaya, İsmet Bulut, Cahi̇t Bi̇lgi̇n, Emel Kurt Jan 2006

Evaluation Of Tumor Markers In Asthma Patients, Abdurrahman Coşkun, Öner Balbay, Özlem Yavuz, Ramazan Memi̇şoğullari, Ali̇ Ni̇hat Annakkaya, İsmet Bulut, Cahi̇t Bi̇lgi̇n, Emel Kurt

Turkish Journal of Medical Sciences

Background: Although tumor markers have been used as biomarkers for monitoring response to therapy and detecting early relapse in malignancies, it is well known that most tumor marker increases are not specific enough to be used for diagnosis of cancer. Aim: The aim of this study was to investigate the serum concentrations of \alpha -fetoprotein (AFP), carcinoembryonic antigen (CEA), cancer antigen (CA) 19-9, CA 125, CA 15-3 and IgE in asthma patients. Materials and Methods: Thirty-five newly diagnosed asthmatic patients and 14 healthy subjects were included into the study. Blood samples were drawn from antecubital vein of asthma patients and …


The Effects Of Asthma Education On Knowledge, Behavior And Morbidity In Asthmatic Patients, Rezan Demi̇ralay Jan 2004

The Effects Of Asthma Education On Knowledge, Behavior And Morbidity In Asthmatic Patients, Rezan Demi̇ralay

Turkish Journal of Medical Sciences

This work was carried out to study the effect of asthma education on asthma knowledge, behavior and morbidity in asthmatic patients. A randomized double blind controlled study was conducted with 54 adults with asthma followed-up at the outpatient clinic of Chest Diseases and Tuberculosis at the Faculty of Medicine of Suleyman Demirel University. Patients were randomized to the verbal (n: 17), written (n: 19), and verbal-written (n: 18) education groups. Knowledge of asthma was measured at the baseline, and 2 months and 1 year after education. Compliance with treatment, correct inhaler skill and admisssons to hospital in the previous year …


Comparison Of The Effects Of Three Forms Of Individualized Education On Asthma Knowledge In Asthmatic Patients, Rezan Demi̇ralay Jan 2002

Comparison Of The Effects Of Three Forms Of Individualized Education On Asthma Knowledge In Asthmatic Patients, Rezan Demi̇ralay

Turkish Journal of Medical Sciences

This study was carried out to compare the effects of three forms of individualized education (verbal, written, and verbal-written) on asthma knowledge in asthmatic patients. For this purpose, a randomized double blind controlled study was conducted with 62 adults with asthma followed-up at the outpatient clinic of Chest Diseases and Tuberculosis of the Faculty of Medicine of Suleyman Demirel University. Patients were randomized to the verbal (n:20), written (n:20), and verbal-written (n:22) education groups. Knowledge of asthma was measured at the baseline and 2 months after education. Before education, knowledge of asthma was low in the three education groups. The …


Prevalence Of Asthma And Asthma-Like And Allergic Symptoms In The Urban Adult Population Of Elazığ, Tuncer Tuğ, Yasemi̇n Açik, Esra Tuğ Jan 2002

Prevalence Of Asthma And Asthma-Like And Allergic Symptoms In The Urban Adult Population Of Elazığ, Tuncer Tuğ, Yasemi̇n Açik, Esra Tuğ

Turkish Journal of Medical Sciences

The aim of this study was to determine the prevalence of asthma, asthma-like symptoms and atopy in the adult population of the city of Elazığ. A specific questionnaire, adopted from the European Community Respiratory Health Survey including social status and smoking tendencies of people was filled in by 2454 randomly chosen (1088 male, 1366 female) subjects. The cumulative prevalence of asthma and asthma-like symptoms for males, females and the general population was 22.0%, 28.7%, and 25.7%, respectively. The periodic prevalences of them were 17.3%, 20.5%, and 19.1%, while rates of previously diagnosed asthma were 2.6%, 3.5%, and 3.1%. Subjects suffering …