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Articles 1 - 30 of 105
Full-Text Articles in Medicine and Health Sciences
Current Trends And Future Implications In Sepsis Treatment, Bariş Doğu Yildiz, Kaya Yorganci
Current Trends And Future Implications In Sepsis Treatment, Bariş Doğu Yildiz, Kaya Yorganci
Turkish Journal of Medical Sciences
Sepsis is a systemic illness caused by invasion of tissues by pathogens. It is highly lethal, causing circulatory failure and death. There has been extensive research trying to identify possible therapies for sepsis. Apart from source control, and antibiotic and supportive therapy, glucocorticoids, anticoagulant agents, and immunoglobulins have been tried in both the experimental setting and in septic patients. Newer strategies include novel anticoagulant agents like ethyl pyruvate, statins, insulin receptor modulators and Toll-like receptor modulators. This review article summarizes both the current therapies and endeavors for future treatment in sepsis.
Is Cd117 Expression Related With Plasma Cell Differentiation, Irf4/Mum1 And Cd38 Expressions In Lymphoid Neoplasms?, Gülşah Kaygusuz, Işinsu Kuzu, Saba Ki̇remi̇tçi̇, Duygu Kankaya, Zeynep Biyikli
Is Cd117 Expression Related With Plasma Cell Differentiation, Irf4/Mum1 And Cd38 Expressions In Lymphoid Neoplasms?, Gülşah Kaygusuz, Işinsu Kuzu, Saba Ki̇remi̇tçi̇, Duygu Kankaya, Zeynep Biyikli
Turkish Journal of Medical Sciences
Aim: In this study, we aimed to assess the expression of CD117 in a large series of both Hodgkin´s and non-Hodgkin´s lymphoma, and to investigate the association between the expression patterns of CD117, IRF4/MUM1, and CD38. Materials and Methods: A total of 237 lymphoma cases were selected and examined within six tissue microarray paraffin blocks. Immunohistochemistry was performed using antibodies against CD117, IRF4/MUM1 and CD38. Results: CD117 and IRF4/MUM1 immunoreactivity were seen in a subset of high-grade and low-grade B-cell lymphomas, as well as T-cell lymphomas and classical type Hodgkin´s lymphomas. CD38 positivity was only detected in 1% of diffuse …
The Effect Of Caffeic Acid Phenethyl Ester (Cape) Treatment On Levels Of Mda, No And Antioxidant Enzyme Activities In Retinas Of Streptozotocin-Induced Diabetic Rats, Mustafa Durmuş, H. Ramazan Yilmaz, Efkan Uz, Nurten Özçeli̇k
The Effect Of Caffeic Acid Phenethyl Ester (Cape) Treatment On Levels Of Mda, No And Antioxidant Enzyme Activities In Retinas Of Streptozotocin-Induced Diabetic Rats, Mustafa Durmuş, H. Ramazan Yilmaz, Efkan Uz, Nurten Özçeli̇k
Turkish Journal of Medical Sciences
Aim: This study was performed to determine the effect of caffeic acid phenethyl ester (CAPE) treatment on levels of malondialdehyde (MDA) and nitric oxide (NO) and activities of antioxidant enzymes in retinas of streptozotocin (STZ)-induced diabetic rats. Materials and Methods: Twenty-seven rats were enrolled and divided into three groups: group 1: non-diabetic rats as control (n = 9); group 2: STZ-induced, untreated diabetic rats (n = 8); and group 3: STZ-induced, CAPE-treated diabetic rats (n = 10). Levels of MDA and NO and the activities of superoxide dismutase (SOD) and glutathione peroxidase (GSH-Px) in retinal tissues were analyzed. Results: In …
The Effect Of Erythropoietin On Neurotrophic Factors In N9 Murine Microglial Cells, Fi̇li̇z Kuralay, Başak Bi̇ngöl Çakirli, Şermi̇n Genç
The Effect Of Erythropoietin On Neurotrophic Factors In N9 Murine Microglial Cells, Fi̇li̇z Kuralay, Başak Bi̇ngöl Çakirli, Şermi̇n Genç
Turkish Journal of Medical Sciences
Aim: In this study, we investigated whether interferon gamma (IFN\gamma), lipopolysaccharides (LPS) and amyloid beta (AMY\beta), as toxic stimulator agents, and erythropoietin (EPO), as a neurotrophic agent, have an effect on the production of the following neurotrophic factors in the N9 murine microglia cell line: neurotrophin 3 (NT3), neurotrophin 4 (NT4), and brain-derived neurotrophic factor (BDNF). Materials and Methods: Microglial cells were incubated with 50 μg/ml AMY\beta, or 1 μg/ml of LPS plus 100 U/ml recombinant murine IFN\gamma, and/or one of three different concentrations (0.1, 1.0, and 5.0 U/ml) of recombinant mouse EPO for 24 h. Results: EPO 0.1 U/ml …
Total Antioxidant Capacity And C-Reactive Protein Levels In Patients With Community-Acquired Pneumonia, Ahmet Bi̇rcan, Recep Sütçü, Müni̇re Gökirmak, Hi̇cran Hi̇çyilmaz, Ahmet Akkaya, Önder Öztürk
Total Antioxidant Capacity And C-Reactive Protein Levels In Patients With Community-Acquired Pneumonia, Ahmet Bi̇rcan, Recep Sütçü, Müni̇re Gökirmak, Hi̇cran Hi̇çyilmaz, Ahmet Akkaya, Önder Öztürk
Turkish Journal of Medical Sciences
Aims: The aim of this study was to evaluate the oxidative stress measured by serum total antioxidant capacity (TAC) and malondialdehyde (MDA) in patients with community-acquired pneumonia (CAP), and to evaluate their possible correlation with the serum C-reactive protein (CRP) and pneumonia severity index (PSI). Materials and Methods: The PSI, chest X-ray (CXR) scores, and the serum TAC, MDA, and CRP levels were determined in 67 CAP patients on admission and compared to 45 healthy controls. Results: In the whole study population, the TAC level was inversely correlated with CRP levels and WBC counts (r=-0.648, P=0.0001; r=-0.626, P=0.0001, respectively). Lower …
Effect Of Metformin Or Gliclazide On Lipid Peroxidation And Antioxidant Levels In Patients With Diabetes Mellitus, Ramazan Memi̇şoğullari, Mehmet Türkeli̇, Ebubeki̇r Bakan, Fati̇h Akçay
Effect Of Metformin Or Gliclazide On Lipid Peroxidation And Antioxidant Levels In Patients With Diabetes Mellitus, Ramazan Memi̇şoğullari, Mehmet Türkeli̇, Ebubeki̇r Bakan, Fati̇h Akçay
Turkish Journal of Medical Sciences
Aim: The association between oxidative stress and diabetic complications is well known. The main goal of antidiabetic therapy is to prevent the complications of diabetes. Gliclazide (sulfonylurea) and metformin (biguanide) are two oral antidiabetic drugs that have been proven to prevent diabetic complications. In this study, we aimed to investigate the antioxidant effects of gliclazide or metformin. Materials and Methods: In this study, we evaluated 46 patients with type 2 diabetes mellitus. The patients were divided into three groups according to their treatment modality of gliclazide, metformin, or diet. Erythrocyte glutathione peroxidase (Gpx), glutathione S-transferase (GST), and catalase (CAT) activities …
Peripheral Blood Lymphocyte Activation And Rantes Levels In Asthma, Gaye Erten, Benan Müselli̇m, Bülent Tutluoğlu, Bi̇lun Gemi̇ci̇oğlu, Günnur Deni̇z
Peripheral Blood Lymphocyte Activation And Rantes Levels In Asthma, Gaye Erten, Benan Müselli̇m, Bülent Tutluoğlu, Bi̇lun Gemi̇ci̇oğlu, Günnur Deni̇z
Turkish Journal of Medical Sciences
Aim: Bronchial mucosal inflammation is one of the major characteristics of atopic asthma. Th2 activation and the related cytokine profile, eosinophil activation and infiltration play the main role in the pathogenesis of atopic asthma. The aim of this study was to demonstrate the activation and RANTES (regulated on activation, normal T-cell expressed and presumably secreted) expression of peripheral blood lymphocytes of non-atopic and atopic asthmatic patients. Materials and Methods: CD3, CD4, CD8, CD16, CD23, CD25, CD45RA and CD45RO expressions were determined in 22 asthma patients and 20 healthy control subjects by flow cytometry, and RANTES levels were measured by ELISA. …
Evaluation Of Middle Ear Ventilation After Tympanoplasty By Xe-133 Scintigraphy, Hülya Ortapamuk, Hakan Korkmaz, Zeynel Öztürk, Güleser Saylam, Engi̇n Dursun, Adi̇l Eryilmaz
Evaluation Of Middle Ear Ventilation After Tympanoplasty By Xe-133 Scintigraphy, Hülya Ortapamuk, Hakan Korkmaz, Zeynel Öztürk, Güleser Saylam, Engi̇n Dursun, Adi̇l Eryilmaz
Turkish Journal of Medical Sciences
Aim: Eustachian tube is considered to have important role in the normal physiology of middle ear, as well as in the success of tympanoplasty operations. The study was designed prospectively to reveal the role of Xe-133 ventilation scintigraphy in the determination of eustachian tube (ET) function. Materials and Methods: Thirteen patients who underwent successful tympanoplasty with intact graft and 5 healthy volunteers were included in this study. Xe-133 insufflation into nasopharynx was done using a polyethylene 7F catheter and the patient was asked to perform valsalva maneuver followed by swallowing. Time-activity curves were generated from the region of interest (ROI) …
Measuring Functional Change In Turkish Children With Cerebral Palsy Using The Pediatric Evaluation Of Disability Inventory (Pedi), Hülya Şi̇rzai̇, Gülten Erki̇n, Canan Çulha, Sumru Özel
Measuring Functional Change In Turkish Children With Cerebral Palsy Using The Pediatric Evaluation Of Disability Inventory (Pedi), Hülya Şi̇rzai̇, Gülten Erki̇n, Canan Çulha, Sumru Özel
Turkish Journal of Medical Sciences
Aim: The purposes of this study were to evaluate the activities of daily living (ADL) of Turkish children with cerebral palsy (CP) using the Turkish version of the Pediatric Evaluation of Disability Inventory (PEDI) measurement, and to investigate the functional changes during inpatient rehabilitation. Materials and Methods: A total of 90 consecutive children with spastic CP, aged between 6 months and 7 years, were included in the study. The Swedish classification of CP syndromes was applied. CP severity was classified with Gross Motor Function Classification System (GMFCS). ADL were assessed in children with CP using the Turkish version of the …
Is Cervicotomy Enough For Removal Of Retrosternal Goiters?, Berkant Özpolat, Oktay Büyükaşik, Celal Gökhan Osmanoğlu, Süheyla Doğan, Hülagü Kargici
Is Cervicotomy Enough For Removal Of Retrosternal Goiters?, Berkant Özpolat, Oktay Büyükaşik, Celal Gökhan Osmanoğlu, Süheyla Doğan, Hülagü Kargici
Turkish Journal of Medical Sciences
Aim: The aim of this study was to evaluate the surgical approaches in retrosternal goiters. Materials and Methods: We reviewed 23 patients operated with the diagnosis of retrosternal goiter. Twelve (52%) of the cases were female and 11 (48%) were male. Mean age was 53.8±10.9 years. Shortness of breath was seen in 12 (52%) of the patients as the most frequent preoperative symptom. On the chest posteroanterior radiography, 18 (78%) cases were found to have tracheal compression. CT images demonstrated retrosternal extension to the level of the aortic arch in all patients. All 23 patients were prepared for a thoracic …
Forensic Emergency Medicine - Six-Year Experience Of 13823 Cases In A University Emergency Department, Ahmet Demi̇rcan, Ayfer Keleş, Nesli̇han Gürbüz, Fi̇kret Bi̇ldi̇k, Şahender Gülbi̇n Aygencel, Nuretti̇n Özgür Doğan, Okşan Deri̇nöz, Taner Akar
Forensic Emergency Medicine - Six-Year Experience Of 13823 Cases In A University Emergency Department, Ahmet Demi̇rcan, Ayfer Keleş, Nesli̇han Gürbüz, Fi̇kret Bi̇ldi̇k, Şahender Gülbi̇n Aygencel, Nuretti̇n Özgür Doğan, Okşan Deri̇nöz, Taner Akar
Turkish Journal of Medical Sciences
Aims: Clinical forensic medicine deals with cases involving both the legal and medical aspects of patient care, such as motor vehicle trauma or poisoning. In this study, we aimed to draw attention to the forensic issues by retrospective investigation of 13823 emergency cases and to share our experiences on this topic. Materials and Methods: This retrospective study was conducted in a university Emergency Department (ED) in Ankara, Turkey. The data were collected from official hospital police sheets. Results: Between 2000 and 2005, 13823 legal cases (3.66% of all ED patients) were examined, and 58.23% of them were male. The mean …
Effects Of Pretreatment With Lidocaine Or Ketamine On Injection Pain And Withdrawal Movements Of Rocuronium, Taylan Akkaya, Pinar Toygar, Nurdan Bedi̇rli̇, Di̇lek Yazicioğlu, Haluk Gümüş
Effects Of Pretreatment With Lidocaine Or Ketamine On Injection Pain And Withdrawal Movements Of Rocuronium, Taylan Akkaya, Pinar Toygar, Nurdan Bedi̇rli̇, Di̇lek Yazicioğlu, Haluk Gümüş
Turkish Journal of Medical Sciences
Aims: The incidence and severity of pain on injection of rocuronium and its pretreatment with saline, lidocaine or ketamine were evaluated. Materials and Methods: One hundred and twenty patients were randomized into three groups to receive intravenous (i.v.) lidocaine 30 mg (Group Lidocaine, n=40), ketamine 0.5 mg/kg (Group Ketamine, n=40) or saline 2 ml (Group Saline, n=40). Thirty seconds after the pretreatment drug, intubation dose of rocuronium (0.6 mg/kg) was injected by i.v. route in 5 seconds. The pain and the withdrawal movements were assessed by a five-point and a four-point scale, respectively. Six hours after anesthesia, patients were asked …
Surveillance Of Nosocomial Infections In Dicle University Hospital: A Ten-Year Experience, Mehmet Faruk Geyi̇k, Sali̇h Hoşoğlu, Celal Ayaz, Mustafa Kemal Çelen, Cemal Üstün
Surveillance Of Nosocomial Infections In Dicle University Hospital: A Ten-Year Experience, Mehmet Faruk Geyi̇k, Sali̇h Hoşoğlu, Celal Ayaz, Mustafa Kemal Çelen, Cemal Üstün
Turkish Journal of Medical Sciences
Aim: The main objective was to recognize the evaluation of surveillance program on the nosocomial infections (NIs) in Dicle University Hospital (DUH) Materials and Methods: A prevalence study was performed prospectively, at the DUH from 1997 to 2006. Active surveillance for NIs were performed by infection control team, using the criteria proposed by the Centers for Diseases Control and Prevention (CDC) and National Nosocomial Infections Surveillance System (NNIS) methodology. This team includes infection control doctor and two nurses, who visited hospital units three times a week. All cases with NI were recorded using a standard data collection form. Results: During …
Natal And Postnatal Approach In A Fetus With Intrauterine Cystic Hygroma: Case Report, Canan Atalay, Şeyda Aykan, Ednan Bayram, Nazim Doğan
Natal And Postnatal Approach In A Fetus With Intrauterine Cystic Hygroma: Case Report, Canan Atalay, Şeyda Aykan, Ednan Bayram, Nazim Doğan
Turkish Journal of Medical Sciences
Cystic hygroma (CH) is a neonatal abnormality that may cause respiratory problems especially due to pressure of huge masses located in the neck and thorax on the vital organs. A mother already known to have an intrauterine baby with CH underwent operation under general anesthesia. The newborn, who had cyanotic and respiratory problems, was immediately intubated and operated the day following delivery. This case report is intended to elaborate and discuss anesthesia in a newborn with CH and the mother.
Reproductive Health Training Of Turkish Soldiers From Certain Risk Groups, Ercan Göçgeldi̇, Bi̇lal Bakir, Aygül Akyüz, Mahi̇r Güleç, Tülay Kaya, Sadetti̇n Güngör, Meti̇n Hasde
Reproductive Health Training Of Turkish Soldiers From Certain Risk Groups, Ercan Göçgeldi̇, Bi̇lal Bakir, Aygül Akyüz, Mahi̇r Güleç, Tülay Kaya, Sadetti̇n Güngör, Meti̇n Hasde
Turkish Journal of Medical Sciences
Aims: The 2003 Turkey Demographic and Health Survey (TDHS-2003) pointed out significant differences between East Anatolia and the other regions of Turkey. Some studies carried out among Turkish soldiers have underlined the need for more information on Reproductive Health (RH) issues for soldiers with lower educational level and coming from the eastern region of Turkey. Since marriage in Turkey is very important from a demographic perspective, this study has attempted to determine prevalence of marriage and certain characteristics of married soldiers who were involved in the RH courses. The aim of the study was to determine the results of RH …
Second-Hand Tobacco Smoke And Acute Eosinophilic Pneumonia, Zekai̇ Avci, Bülent Ali̇oğlu, Emel Özyürek, Namik Özbek
Second-Hand Tobacco Smoke And Acute Eosinophilic Pneumonia, Zekai̇ Avci, Bülent Ali̇oğlu, Emel Özyürek, Namik Özbek
Turkish Journal of Medical Sciences
We present the case reports of two children with a parasitic infestation associated with hypereosinophilia. One of those patients, who had been exposed to excessive second-hand tobacco smoke, was diagnosed as having acute eosinophilic pneumonia. The second patient had neither a history of exposure to second-hand smoke nor a prior diagnosis of acute eosinophilic pneumonia. We suggest that passive smoking may trigger acute eosinophilic pneumonia, a condition that develops frequently in children living in countries in which parasitic infestations and tobacco smoking are prevalent.
In Vitro Activity Of Tigecycline Against Acinetobacter Baumannii Strains Isolated From Nosocomial Infections, Esragül Akinci, İpek Mumcuoğlu, Pinar Öngürü, F. Nurhayat Bayazit, Sevi̇nç Ersoy Şen, Ayşe Erbay, Neri̇man Balaban, Hürrem Bodur
In Vitro Activity Of Tigecycline Against Acinetobacter Baumannii Strains Isolated From Nosocomial Infections, Esragül Akinci, İpek Mumcuoğlu, Pinar Öngürü, F. Nurhayat Bayazit, Sevi̇nç Ersoy Şen, Ayşe Erbay, Neri̇man Balaban, Hürrem Bodur
Turkish Journal of Medical Sciences
Aims: Acinetobacter species usually affect hospitalized patients and are involved in many infections associated with a high mortality rate. Management of infections caused by these strains is very difficult, as the strains often display multiple drug resistance, including carbapenem resistance. Tigecycline is the most recently developed semi-synthetic broad spectrum glycylcycline antibiotic. The present study was conducted to evaluate the in vitro susceptibility of Acinetobacter baumannii strains isolated from the hospitalized patients to tigecycline. Materials and Methods: Acinetobacter isolates were collected from hospitalized patients with documented nosocomial infections between June 2005 and October 2006. Only one isolate per patient was accepted. …
Cause Of Fever In A Case With End-Stage Renal Disease: Splenic Marginal Zone Lymphoma, Ramazan Çeti̇nkaya, İlhami̇ Ki̇ki̇, Abdullah Uyanik, Mustafa Keleş, Bülent Aydinli, Fazli Erdoğan, Nesri̇n Gürsan, Abdul Meci̇t Kantarci
Cause Of Fever In A Case With End-Stage Renal Disease: Splenic Marginal Zone Lymphoma, Ramazan Çeti̇nkaya, İlhami̇ Ki̇ki̇, Abdullah Uyanik, Mustafa Keleş, Bülent Aydinli, Fazli Erdoğan, Nesri̇n Gürsan, Abdul Meci̇t Kantarci
Turkish Journal of Medical Sciences
Splenic marginal zone lymphomas (SMZL) are rare tumors arising from B-cells, accounting for approximately 1% of all lymphomas. An accompanying lymphoma is uncommon in patients who have chronic renal failure and undergo hemodialysis. We present herein a 35-year-old male hemodialysis patient admitted with fever, abdominal pain, and splenomegaly, diagnosed with SMZL. In our investigations in the English literature, we did not observe any SMZL case among hemodialysis patients. Fever may emerge due to different causes in chronic hemodialysis patients, primarily infections. In hemodialysis patients presenting with fever, lymphoma and other malignant diseases should be considered.
Oropharyngeal Anthrax, Abdullah Taş, Recep Yağiz, Şaban Gürcan, Deni̇z Karaoğlu
Oropharyngeal Anthrax, Abdullah Taş, Recep Yağiz, Şaban Gürcan, Deni̇z Karaoğlu
Turkish Journal of Medical Sciences
Aims: To report a rare case of oropharyngeal anthrax. Materials and Methods: A case report of oropharyngeal anthrax is presented together with the related world literature. Results: A 70-year-old female patient with respiratory distress and extensive swelling of neck, soft palate and uvula is presented. There was ecchymosis on the neck circumferentially. Bacillus anthracis grew in the blood culture. The patient died of toxemia and sepsis. Conclusions: Oropharyngeal anthrax is the least common form of anthrax. This acute illness should be added to the differential diagnosis of inflammatory lesion of the oropharynx with extensive neck swelling. Successful diagnosis of anthrax …
An Unusual Cause Of Dysphagia: Hypopharyngeal Inflammatory Pseudotumor, Baran Acar, Mehmet Ali̇ Babademez, Hayri̇ye Karabulut, Selahatti̇n Genç, R. Murat Karaşen
An Unusual Cause Of Dysphagia: Hypopharyngeal Inflammatory Pseudotumor, Baran Acar, Mehmet Ali̇ Babademez, Hayri̇ye Karabulut, Selahatti̇n Genç, R. Murat Karaşen
Turkish Journal of Medical Sciences
Inflammatory pseudotumor (IP) is a rare pseudoneoplastic and lymphoproliferative disorder. The etiology of IP is still unclear. A 46-year-old male patient presented with a six-month history of dysphagia and diplophonia. Endoscopic examination of the larynx and hypopharynx revealed a 15 x 20 mm smooth-surfaced mass involving the right side of the hypopharynx. Computerized tomography (CT) scans of the neck showed a mass 3 cm in diameter at the level of the hyoid bone. The mass obliterated the pharyngeal lumen. Pathology after incisional biopsy was consistent with pseudotumor. The mass regressed dramatically after corticosteroid treatment and afterwards the patient underwent surgical …
Functional Vitamin B12 Deficiency Represented By Elevated Urine Methylmalonic Acid Levels In Patients With Migraine, Osman Meti̇n İpçi̇oğlu, Ömer Özcan, Mustafa Gültepe, Hakan Tekeli̇, Mehmet Güney Şenol
Functional Vitamin B12 Deficiency Represented By Elevated Urine Methylmalonic Acid Levels In Patients With Migraine, Osman Meti̇n İpçi̇oğlu, Ömer Özcan, Mustafa Gültepe, Hakan Tekeli̇, Mehmet Güney Şenol
Turkish Journal of Medical Sciences
Aims: Although vitamin B12 is currently used as a treatment option in patients with migraine, a possible cobalamin deficiency in those patients has not yet been investigated. In this study, we aimed to investigate cobalamin metabolism in patients with migraine. Materials and Methods: Fifty women having migraine without aura were matched with healthy controls (n=6) with the same age distribution. Fasting serum vitamin B12, folate, plasma total homocysteine (tHcy) and first morning urine methylmalonic acid (MMA) levels were determined in patient and control groups. Statistical differences in laboratory parameters between patient and control groups were analyzed by SPSS for Windows …
Classification Of Sigmoid Volvulus, S. Selçuk Atamanalp, Bülent Aydinli, Gürkan Öztürk, Mahmut Başoğlu, M. İlhan Yildirgan, Durkaya Ören, Abdul Meci̇t Kantarci
Classification Of Sigmoid Volvulus, S. Selçuk Atamanalp, Bülent Aydinli, Gürkan Öztürk, Mahmut Başoğlu, M. İlhan Yildirgan, Durkaya Ören, Abdul Meci̇t Kantarci
Turkish Journal of Medical Sciences
Aim: The aim of this study was to establish a classification that will aid in the surgical treatment and prognosis of sigmoid volvulus (SV). Materials and Methods: The records of 420 patients with SV who were treated surgically during a 41.5-year period were reviewed retrospectively. The preoperative and operative criteria that were significantly correlated with mortality were determined. Results: Of 420 patients, 68 (16.2%) died. Age over 60 years (P < 0.001), associated disease (P < 0.001), presence of shock (P < 0.001), and presence of sigmoid colon gangrene (P < 0.001) were significantly correlated with mortality. A classification was made using these criteria. Conclusions: Recommended treatment options and potential mortality rates were determined for each class in the new classification based on the evaluation of the present series, our clinical experience, and literature findings. This classification may be helpful in determination of the surgical treatment and prognosis of SV.
Scie, Impact Factor, Journal Volume And Quality, M. Mahi̇r Özmen
Scie, Impact Factor, Journal Volume And Quality, M. Mahi̇r Özmen
Turkish Journal of Medical Sciences
No abstract provided.
Attenuation Of Vasospasm By Dexmedetomidine After Experimental Subarachnoidal Haemorrhage In Rabbits, Olcay Eser, Hüseyi̇n Fi̇dan, Ömer Çoşkun, Yüksel Ela, Ahmet Songur, Murat Coşar
Attenuation Of Vasospasm By Dexmedetomidine After Experimental Subarachnoidal Haemorrhage In Rabbits, Olcay Eser, Hüseyi̇n Fi̇dan, Ömer Çoşkun, Yüksel Ela, Ahmet Songur, Murat Coşar
Turkish Journal of Medical Sciences
Aim: Vasospasm is one of the most important factors that influence the successful treatment of ruptured intracranial aneurysm. We studied if vasospasm following subarachnoidal haemorrhage (SAH) can be alleviated by dexmedetomidine in an animal model. Materials and Methods: Experimental SAH was induced in 12 of 18 New Zealand rabbits by intracisternal injection of autologous blood. Control animals (sham SAH, n = 6) received intracisternal injection of the respective volume of physiological saline solution. Forty eight hours after the operation, rabbits in sham SAH and SAH-alone (n = 6) groups were infused intravenously with 0.9% sodium chloride for 2 h, whereas …
The Effect Of Alcohol On Total Antioxidant Activity And Nitric Oxide Levels In The Sera And Brains Of Rats, Sevi̇l Kurban, İdri̇s Mehmetoğlu
The Effect Of Alcohol On Total Antioxidant Activity And Nitric Oxide Levels In The Sera And Brains Of Rats, Sevi̇l Kurban, İdri̇s Mehmetoğlu
Turkish Journal of Medical Sciences
Background: The present study investigated the effect of alcohol consumption on total antioxidant activity (AOA) and nitric oxide (NO) levels in the sera and brains of rats. Materials and methods: The study included 24 rats that were divided into 2 groups: the control group (n = 12) and the alcohol group (n = 12). Both groups were fed regular laboratory chow and tap water for a period of 2 months; however, the alcohol group received 15% (v/v) ethanol in their drinking water. Then, the rats were decapitated, and serum and brain AOA and NO levels were measured. Results: Both serum …
Is Mefvgene Arg202gln (605 G>A) A Disease-Causing Mutation?, Ayşenur Öztürk, Bi̇rsi̇n Özçakar, Mesi̇ha Eki̇m, Nejat Akar
Is Mefvgene Arg202gln (605 G>A) A Disease-Causing Mutation?, Ayşenur Öztürk, Bi̇rsi̇n Özçakar, Mesi̇ha Eki̇m, Nejat Akar
Turkish Journal of Medical Sciences
Aim: Familial Mediterranean fever (FMF) is an autosomal recessive disease. Arg202Gln was reported as a frequent polymorphism, and G allele of the mutation was in linkage disequilibrium with M694V. Thus, the aim of this study was to determine the distribution of the R202Q (605G>A) mutation in exon 2 of the MEFVgene in Turkish FMF patients and controls. Materials and Methods: The study included 160 FMF and 41 FMF/amyloid patients and 121 controls. Sequencing of exon 10 and exon 5 and PCR/RFLP analysis of E148Q and R202Q mutations of exon 2 of the MEFVgene were performed for all patients according …
Elective Treatment Of Detorsioned Sigmoid Volvulus, S. Selçuk Atamanalp, Durkaya Ören, Bülent Aydinli, Gürkan Öztürk, K. Yalçin Polat, Mahmut Başoğlu, M. İlhan Yildirgan, Abdul Meci̇t Kantarci, Ahmet A. Balik
Elective Treatment Of Detorsioned Sigmoid Volvulus, S. Selçuk Atamanalp, Durkaya Ören, Bülent Aydinli, Gürkan Öztürk, K. Yalçin Polat, Mahmut Başoğlu, M. İlhan Yildirgan, Abdul Meci̇t Kantarci, Ahmet A. Balik
Turkish Journal of Medical Sciences
Aim: Recurrence after a successful nonoperative detorsion or a nondefinitive operation is an important problem in the treatment of sigmoid volvulus (SV). This study was designed to review the outcomes of elective treatment of successfully detorsioned SV and to discuss the treatment algorithm. Materials and Methods: The records of 873 patients were reviewed retrospectively. Results: Nonoperative treatment was applied in 614 patients. The success, mortality, complication and recurrence rates were 77.5%, 0.8%, 2.8%, and 4%, respectively. Emergency surgical treatment was performed in 416 patients with 15.6% mortality, 36.5% complication, 0.7% early recurrence and 6.5% late recurrence rates. Elective surgical treatment …
Upper Extremity Musculoskeletal Disorders Among Computer Users, Ali̇ Aydeni̇z, Savaş Gürsoy
Upper Extremity Musculoskeletal Disorders Among Computer Users, Ali̇ Aydeni̇z, Savaş Gürsoy
Turkish Journal of Medical Sciences
Aim: The aim of this study was to determine whether upper extremity musculoskeletal disorders are more prevalent in intense computer users and the relation between cumulative hours of computer use and symptoms. Materials and Methods: The study group included 100 bank workers, who worked more than 6 h per day for at least 2 years on a video display unit and were recruited through convenience sampling. Sixty-five age and sex matched healthy subjects who worked not more than 2 h on computer keyboards for office work constituted the control group. Results: There were no significant differences between groups when the …
Structural Changes Of Placenta In Preeclamptic Patients: Light And Electron Microscopic Study, Reda Awadallah Saleh, Mohamed Abdel Monem Dkhil
Structural Changes Of Placenta In Preeclamptic Patients: Light And Electron Microscopic Study, Reda Awadallah Saleh, Mohamed Abdel Monem Dkhil
Turkish Journal of Medical Sciences
Background: Preeclampsia is a disorder that occurs only during pregnancy and the postpartum period and affects both the mother and the unborn baby. It is a rapidly progressive condition characterized by high blood pressure and the presence of protein in the urine. The study was designed to investigate the histological and ultrastructural changes in placentas from pregnancies complicated by preeclampsia. Methods: Paraffin sections from placenta biopsies were prepared for light microscopic examination. For ultrastructural examination, biopsies were prepared and examined by digital scanning electron microscope. Results: Light microscopic examinations showed that the nuclei of syncytiotrophoblast layer were aggregated into clusters …
The Association Of D-Dimer Levels With Other Prognostic Factors In Patients With Lung Cancer, Satilmiş İnal, Cantürk Taşçi, Nuri̇ Karadurmuş, Okan Kuzhan, Arzu Balkan, Meti̇n Özkan, Hayati̇ Bi̇lgi̇ç, Ahmet Özet, Kudret Eki̇z
The Association Of D-Dimer Levels With Other Prognostic Factors In Patients With Lung Cancer, Satilmiş İnal, Cantürk Taşçi, Nuri̇ Karadurmuş, Okan Kuzhan, Arzu Balkan, Meti̇n Özkan, Hayati̇ Bi̇lgi̇ç, Ahmet Özet, Kudret Eki̇z
Turkish Journal of Medical Sciences
Aim: To determine the factors related with coagulation disorders, deep venous thrombosis and thromboembolic events that are significant causes of morbidity and mortality in patients with lung cancer. Materials and Methods: D-dimer (DD) levels at the time of diagnosis were determined in patients diagnosed with lung cancer and these cases were monitored prospectively for thromboembolic events and survival. Results: DD levels significantly increased and were associated with length of survival in lung cancer patients. Age, histopathological type, extent of the disease (stage), DD, performance status (ECOG), and thromboembolism were found to effect survival. DD, thromboembolism, ECOG, and histopathological type were …