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Full-Text Articles in Medicine and Health Sciences

The Role Of Pr Otein Synthesis In The Adhesion Ofchinese Hamster Lung Cells, Ali̇ Yildirim Jan 2000

The Role Of Pr Otein Synthesis In The Adhesion Ofchinese Hamster Lung Cells, Ali̇ Yildirim

Turkish Journal of Medical Sciences

In order to determine the effect of endogenous protein synthesis on CHL cell adhesion, the initial attachment of these cells to tissue culture dishes was measur ed in the pr esence of 1µgml -1 emetine, in which protein synthesis was inhibited by 97% as determined by labeling the cells with [ 3 5 S]-methio-nine. In the pr esence of this drug, 80% of cells were able to adhere after 2 hours of incubation at 37 o C, while, during the same period, 97% of the contr ol cells became attached. Cells str engthen their adhesion foll owinginitial attachment, spreading and …


Calcium And Phosphate Excretion In Preeclampsia, Pervi̇n Vural, Cemi̇l Akgül, Mukaddes Canbaz Jan 2000

Calcium And Phosphate Excretion In Preeclampsia, Pervi̇n Vural, Cemi̇l Akgül, Mukaddes Canbaz

Turkish Journal of Medical Sciences

In preeclampsia, alterations in renal function, electrolyte and water metabolism are common findings. Recent studies have suggested that preeclampsia is associated with hypocalciuria. A total of 59 women were included in the present study, 15 of whom were nonpregnant (NP) healthy women, 20 normotensive pregnant women (NTP), and 24 pregnant women with severe preeclampsia (PEP). We compared the three groups in terms of calcium and phosphate excretion, and some parameters of renal function such as serum urea, creatinine and creatinine clearance. Urinary calcium and phosphate levels in the PEP group were significantly lower than in the NP group (p< 0.001 and p< 0.01, respectively) and NTP group (p< 0.001 and p< 0.01, respectively). The serum urea levels were higher in the PEP group than in the NP and NTP (p< 0.001) groups. The same pattern of increase in the PEP group was valid for serum creatinine concentrations as compared with the NP (p< 0.01) and NTP (p< 0.001) levels. The glomerular filtration rate measured by creatinine clearance was lower in preeclamptic women than in normotensive pregnant women (p< 0.01). Patients with preeclampsia had significantly lower (p< 0.001) excretion of calcium than the NP and NTP groups (p< 0.001). Likewise, the phosphate levels were lower in women with preeclampsia than in the NP and NTP groups (p< 0.01). There was no correlation between parameters of renal function and calcium or phosphate excretion. Hypocalciuria and hypophosphateuria were found to be important features of severe preeclampsia and probably indirectly are related to the altered renal function seen in toxemia of pregnancy.


The Importance Of Fibronectin, Haptoglobin,Ceruloplasmin And Transferrin In The Earlydiagnosis Of Neonatal Sepsis, Ayhan Gazi̇ Kalayci, Fazli Yilmazer, Bahatti̇n Adam, Recep Sancak, Şükrü Küçüködük Jan 2000

The Importance Of Fibronectin, Haptoglobin,Ceruloplasmin And Transferrin In The Earlydiagnosis Of Neonatal Sepsis, Ayhan Gazi̇ Kalayci, Fazli Yilmazer, Bahatti̇n Adam, Recep Sancak, Şükrü Küçüködük

Turkish Journal of Medical Sciences

Serum fibronectin, haptoglobin, ceruloplasmin, and transferrin concentrations were measured in 44 term neonates with culture proven sepsis and a control group of 37 normal neonates of similar age, sex and weight. The white blood cell count, total neutrophil count, and the ratio of band to neutrophils were also determined. While the serum fibronectin and haptoglobin concentrations were significantly different (P


Sonographic Evaluation Of Liver And Spleen Sizein School-Age Children, Kaya Saraç, Ramazan Kutlu, Cengi̇z Yakinci, Yaşar Durmaz, Tamer Baysal, Ünsal Özgen Jan 2000

Sonographic Evaluation Of Liver And Spleen Sizein School-Age Children, Kaya Saraç, Ramazan Kutlu, Cengi̇z Yakinci, Yaşar Durmaz, Tamer Baysal, Ünsal Özgen

Turkish Journal of Medical Sciences

The purpose of this study was to determine normal liver and spleen size variations in school-age children by US. Sonographic measurements were taken with an age and sex stratified random sample of 358 healthy children (188 boys, 170 girls) between the ages of 7 and 12 years. The weight and height of the children were assessed and then the body surface area (BSA) of each child was calculated. The size of the liver was measured in two different planes: the subcostal sagittal (L1), and subcostal semiaxial (L2). Spleen size was measured through a coronal view that included the hilum (S1) …


Establishment Of A Nonradioactive Molecular Diagnosis Of Fragile-X Syndrome, Zehra Oya Uyguner, Bernd Wollnik, Hülya Kayseri̇li̇, Turgut Tükel, Seher Başaran, Memnune Yüksel Apak Jan 2000

Establishment Of A Nonradioactive Molecular Diagnosis Of Fragile-X Syndrome, Zehra Oya Uyguner, Bernd Wollnik, Hülya Kayseri̇li̇, Turgut Tükel, Seher Başaran, Memnune Yüksel Apak

Turkish Journal of Medical Sciences

Fragile-X syndrome is a hereditary dynamic mutation disorder, predominantly caused by a large expansion of CGG trinucleotide repeats in the FMR 1 gene leading to methylation and down regulation of transcription of the gene. For the molecular diagnosis of the disease, the repeat locus in FMR 1 gene is primarily detected by Southern blotting with radioactively labeled probes. Unusually GC rich composition of the expanded region caused technical difficulties during PCR based testing and therefore is not performed by most diagnostic laboratories. We established a Southern blot method and a novel PCR protocol which enables the amplification of normal, premutated …


Identification Of Different Candida Species Isolated In Various Hospitals In Ankara By Fungichrom Test Kit And Their Differentiation By Sds-Page, Özlem Osmanağaoğlu, Nurten Altinlar, Sefa Can Saçilik, Cumhur Çökmüş, Ahmet Akin Jan 2000

Identification Of Different Candida Species Isolated In Various Hospitals In Ankara By Fungichrom Test Kit And Their Differentiation By Sds-Page, Özlem Osmanağaoğlu, Nurten Altinlar, Sefa Can Saçilik, Cumhur Çökmüş, Ahmet Akin

Turkish Journal of Medical Sciences

Identification of 78 Candida isolates was carried out by a commercial Fungichrom test kit, the reliability of which was further confirmed by conventional biochemical tests and the API 20C kit. Differentiation between different Candida species was also observed when sodium dodecyl sulfate polyacrylamide gel electrophoresis (SDS-PAGE) of whole cell proteins was used. The most frequently isolated species of yeast from vaginal swabs obtained from patients was Candida albicans, which accounted for 39 of 78 (50.00%) of the isolates from women in Ankara. The next most frequent Candida species were Candida glabrata ( Torulopsis glabrata) and Candida krusei, which were isolated …


Sarcomatoid Renal Cell Carcinoma And Its Chromophobe Connection, Ali̇ Kemal Uzunlar, Enver Özdemi̇r, Mehmet Yaldiz, Özden Kaya, Adem Arslan Jan 2000

Sarcomatoid Renal Cell Carcinoma And Its Chromophobe Connection, Ali̇ Kemal Uzunlar, Enver Özdemi̇r, Mehmet Yaldiz, Özden Kaya, Adem Arslan

Turkish Journal of Medical Sciences

No abstract provided.


Effects Of Tcdd [2,3,7,8-Tetrachlorodibenzo-P-Dioxin(Tcdd)] On The Early Stage Of Pancreaticcarcinogenesis Induced By Azaserine In The Ratpancreas, Haydar Öztas Jan 2000

Effects Of Tcdd [2,3,7,8-Tetrachlorodibenzo-P-Dioxin(Tcdd)] On The Early Stage Of Pancreaticcarcinogenesis Induced By Azaserine In The Ratpancreas, Haydar Öztas

Turkish Journal of Medical Sciences

TCDD (2,3,7,8-tetrachlorodibenzo -p-dioxin), an addictive substance in cigarettes, has been implicated in the pathogenesis of pancreatic carcinoma. This compound has not been tested previously for carcinogenicity towards the pancreas, although TCDD is a known liver carcinogen. The present study was designed to ascertain whether TCDD may have a promoting effect on the development of precursor pancreatic lesions on the rat exocrine pancreas. For this purpose, 30 out of a total of 60 male Leeds rats aged two weeks received a single weekly i.p. injection of azaserine (30 mg/kg body weight) for 5 weeks. The rest of rats (n=30) were used …


Elevated Serum \Beta-Hcg Levels In Severepreeclampsia, Remzi̇ Gökdeni̇z, Erdal Arigüloğlu, Nursel Bazoğlu, Özcan Balat Jan 2000

Elevated Serum \Beta-Hcg Levels In Severepreeclampsia, Remzi̇ Gökdeni̇z, Erdal Arigüloğlu, Nursel Bazoğlu, Özcan Balat

Turkish Journal of Medical Sciences

Most current hypotheses regarding the pathophysiologic mechanisms of pregnancy-induced hypertention point to early placental abnormalities. Therefore, we attempted to determine whether serum human chorionic gonadotropin (hCG) levels reflect a different trophoblastic secretory response of preeclampsia. Thirteen pregnant women with severe preeclampsia were matched with twenty-one normotensive pregnant women with singleton pregnancies in the third trimester. Serum b-hCG levels were found to be significantly higher in severe preeclampsia, compared with controls (p


Clinical Aspects Of Temporomandibular Disorders, Asi̇ye Nehi̇r Özden, Ahmet Ersan Ersoy, Reha Şükrü Ki̇şni̇şçi̇ Jan 2000

Clinical Aspects Of Temporomandibular Disorders, Asi̇ye Nehi̇r Özden, Ahmet Ersan Ersoy, Reha Şükrü Ki̇şni̇şçi̇

Turkish Journal of Medical Sciences

Temporomandibular disorders are common problems in populations presenting signs and symptoms of muscle and joint pain on palpation, limitations in mandibular motion, joint sounds, pain and locking on mandibular function as well as dental, periodontal, occlusal and psychosocial variables. Problems that involve the temporomandibular joint and related structures include myofacial pain-dysfunction, various internal disarrangements of the joint space and degenerative joint diseases. The aim of this study was to evaluate the distribution of age and sex, the frequency of parafunctions, deviations and the cardinal symptoms related to specific disorders of the TMJ. Patients seeking treatment for temporomandibular disorders were reviewed …


Investigation Of Plaque Formation By Scanningelectron Microscopy, Ece Koparal, Rengi̇n Tütüncü Jan 2000

Investigation Of Plaque Formation By Scanningelectron Microscopy, Ece Koparal, Rengi̇n Tütüncü

Turkish Journal of Medical Sciences

The aim of this study was to investigate plaque formation on natural tooth surfaces by a replica technique, which offers investigation of oral hard tissue surfaces by scanning electron microscopy. This method is recommended in cases where direct investigation is impossible such as when non- extracted teeth are investigated or when extracted teeth are expected to be influenced by the dehydration and drying process. The representative photographs demonstrate the accumulation of plaque in two days.


Serum Carnitine Levels In Patients With Coronaryartery Disease, Serkan Özgi̇rgi̇n, Di̇lek Özmen, Işil Mutaf, Nevbahar Turgan, Hakan Kültürsay, Oya Bayindir, Necla Ni̇şli̇ Jan 2000

Serum Carnitine Levels In Patients With Coronaryartery Disease, Serkan Özgi̇rgi̇n, Di̇lek Özmen, Işil Mutaf, Nevbahar Turgan, Hakan Kültürsay, Oya Bayindir, Necla Ni̇şli̇

Turkish Journal of Medical Sciences

Carnitine is an essential molecule for the transfer of long chain fatty acids through the inner mitochondrial membrane, for beta-oxidation (1). The long chain fatty acids provide a large proportion of the energy requirement of the myocardium. Thus, adequate amounts of tissue carnitine are required to maintain the normal function of the myocardium (2). Experimental studies on acute myocardial ischemia and clinical investigations of patients with congestive cardiac failure have indicated that the myocardial carnitine content was significantly lowered in both conditions, in contrast to raised or normal blood carnitine (3-5). In the present study, alterations in serum carnitine levels …


Alprazolam And Cognitive Behavior Therapy Intreatment Of Panic Disorder, Ahmet Ataoğlu, Mustafa Özkan, Hamdi̇ Tutkun, Abdullah Maraş Jan 2000

Alprazolam And Cognitive Behavior Therapy Intreatment Of Panic Disorder, Ahmet Ataoğlu, Mustafa Özkan, Hamdi̇ Tutkun, Abdullah Maraş

Turkish Journal of Medical Sciences

Panic is an often incapacitating and chronic disorder. Cognitive behaviour therapy (CBT) and alprazolam have been shown to be effective in the treatment of panic disorder. Patients who met the DSM-III-R criteria for panic disorder, were randomized and given 16 weeks of double-blind treatment with CBT (n=16), or alprazolam of up to 6 mg/day (n=18). The 17-item HAM-D and HAM-A scales were administered to all the subjects before and after treatment, which took place over 16 weeks, and the changes in the scores were analyzed. The patients' anxiety levels and numbers of panic attacks were assessed at the beginning of …


Obesity And The Activity Of The Autonomicnervous System, Rami̇s Çolak, Emi̇r Dönder, Azi̇z Karaoğlu, Oğuz Ayhan, Mehmet Yalniz Jan 2000

Obesity And The Activity Of The Autonomicnervous System, Rami̇s Çolak, Emi̇r Dönder, Azi̇z Karaoğlu, Oğuz Ayhan, Mehmet Yalniz

Turkish Journal of Medical Sciences

This study was conducted to examine the autonomic nervous system functions of obese people. The study group consisted of 30 healthy obese people (20 female, 10 male, age range 18-58, median 37.6±9.7 years of age) and the control group consisted of 30 healthy nonobese people (18 female, 12 male, age range 17- 56, median 34.4±7.5 years). Each function was tested by non-invasive applications (orthostatic test, isometric exercise test, Valsalva ratio test, 30/15 ratio test, heart rate change test by deep respiration). The results of the orthostatic test and isometric- exercise test yielded a statistically significant difference between the study and …


The Effects Of Sodium Selenite On The Antioxidative Defence Mechanism Of Human Hepatoma G_2 Cells, Kayahan Fişkin Jan 2000

The Effects Of Sodium Selenite On The Antioxidative Defence Mechanism Of Human Hepatoma G_2 Cells, Kayahan Fişkin

Turkish Journal of Medical Sciences

Human cells that live in biological harmony can become cancerous. As they do so, they engage in anaerobic respiration, undergo rapid cell growth and division according to nonmitotic rules, and important changes take place in their metabolism. We conducted several investigations in an effort to block or change the metabolic characteristics of cancer cells using a typical cancerous cell line. Specifically,we investigated the effects of sodium selenite (Na_2 SeO_ 3 ) on antioxidant enzyme activities and reduced glutathione levels in Hepatoma G_ 2 cells, cells that show rapid glutamine uptake and metabolism. A Hepatoma G_ 2 cell line was cultured …


Effects Of Growth Hormone On Bacterial Translocation Due To Intestinal Obstruction, Ahmet A. Balik, M. İlhan Yildirgan, Ali̇ Kiliç, Cemal Gündoğdu, Fazli Erdoğan Jan 2000

Effects Of Growth Hormone On Bacterial Translocation Due To Intestinal Obstruction, Ahmet A. Balik, M. İlhan Yildirgan, Ali̇ Kiliç, Cemal Gündoğdu, Fazli Erdoğan

Turkish Journal of Medical Sciences

Bacterial translocation is an important etiologic factor in multisystem organ failure and sepsis, which have a high mortality rate. To determine the effects of growth hormone on bacterial translocation, an experimental study was performed. Twenty pathogen-free rabbits were divided into two groups each containing 10 rabbits. After loop obstruction was performed, the rabbits in the control group were given saline solution whereas the rabbits in the study group received growth hormone. Relaparotomy was performed after 24 hours, and tissue and blood samples were collected for histopathologic and microbiologic examinations. Bacterial translocation rates were higher in the control group than in …


Abnormalities Of The Midline Cavities Of The Brain: A Computerized Tomography Study, Zehra Akgün, Erdem Gümüşburun, Mustafa Akgün, H. Murat Göksel, Ferruh Yücel Jan 2000

Abnormalities Of The Midline Cavities Of The Brain: A Computerized Tomography Study, Zehra Akgün, Erdem Gümüşburun, Mustafa Akgün, H. Murat Göksel, Ferruh Yücel

Turkish Journal of Medical Sciences

This is a preliminary study carried out on the adult population of the Sivas region. The aim was to determine the incidence of Cavum Septum Pellucidum (CSP), Cavum Vergae (CV) and Cavum Velum Interpositi (CVI) and to compare the results with the data of previous studies and the relevant literature. A total of 442 computed tomography (CT) scans (302 males, 140 females), in axial plane, from the archive of the Department of Neurosurgery at Cumhuriyet University were examined to find out the brain midline cavities. Among the 442 CT scans, 69 (15.61%) had these brain midline cavities. Out of these …


Decreased Placental Adrenomedullin May Play Role In Preeclampsia, Remzi̇ Gökdeni̇z, Muhi̇tti̇n Yürekli̇, Alanur Menekşe, Nursel Bazoğlu Jan 2000

Decreased Placental Adrenomedullin May Play Role In Preeclampsia, Remzi̇ Gökdeni̇z, Muhi̇tti̇n Yürekli̇, Alanur Menekşe, Nursel Bazoğlu

Turkish Journal of Medical Sciences

Adrenomedullin (AdM) is a novel peptide that elicits a long-lasting vasorelaxant activity. It is expressed in several tissues, including adrenal medulla, heart, lung, kidneys, and cultured vascular smooth muscle cells. Also in large amounts, it is present in amniotic fluid and cord blood. The aim of this study was to assess placental AdM secretion in preeclampsia. Placental tissues were collected from seven preeclamptic patients and ten healthy gravidas. Tissue concentration of rat AdM was measured by using reverse-phase high performance liquid chromatography (Cecil 1100). Mann Whitney U test was used for statistical significance. Significance was set at p


Lymphocyte Subsets In Acute Post-Streptococcal Glomerulonephritis, Yavuz Tekeli̇oğlu, Hi̇lal Mocan, M. Zi̇ya Mocan, H. Önder Ersöz Jan 2000

Lymphocyte Subsets In Acute Post-Streptococcal Glomerulonephritis, Yavuz Tekeli̇oğlu, Hi̇lal Mocan, M. Zi̇ya Mocan, H. Önder Ersöz

Turkish Journal of Medical Sciences

This prospective study was designed to investigate lymphocyte subsets in acute post-streptococcal glomerulonephritis (APSGN). Peripheral blood lymphocytes were analyzed using fluorescein isothiocyanate (FITC) labeled CD3, CD4, CD8, CD14, CD19, CD45, CD56, CD45RA and CDW29 monoclonal antibodies by flow cytometry. Twenty patients aged 14-22 years who fulfilled the diagnostic criteria for APSGN were evaluated during the 1st and 12th weeks of the of disease. Twenty-four age-matched healthy subjects served as controls. At the onset of the disease, all patients had macroscopic haematuria with red blood cell casts in urine, proteinuria (1.06±0.21 g/d), low complement 3 (C3) levels (200 IU/ml), edema, oliguria …


Evaluation Of Chitosan As A Potential Medical Iron (Iii) Ion Adsorbent, Ayer Burke, Elvan Yilmaz, Nesri̇n Hasirci Jan 2000

Evaluation Of Chitosan As A Potential Medical Iron (Iii) Ion Adsorbent, Ayer Burke, Elvan Yilmaz, Nesri̇n Hasirci

Turkish Journal of Medical Sciences

Chitosan, a derivative of the natural polysaccharide chitin, is known for its biocompatibility and metal-binding capacity. The aim of this study was to combine these two properties of chitosan and investigate its potential as a new iron (III) ion (ferric ion) adsorbing agent. The development of a safe and orally active iron chelating agent is especially important for the treatment of thalassemics. In this study, the physicochemical parameters affecting the ability of chitosan flakes to adsorb iron (III) ions were studied by complexometric titration. The results showed that the iron (III) adsorption capacity of chitosan increases with the amount of …


Electrochemical Biosensor Based On Horseradish Peroxidase For The Determination Of Oxidizable Drugs, Arzum Erdem, Aysun Pabuccuoğlu, Burcu Meric, Kagan Kerman, Mehmet Özsöz Jan 2000

Electrochemical Biosensor Based On Horseradish Peroxidase For The Determination Of Oxidizable Drugs, Arzum Erdem, Aysun Pabuccuoğlu, Burcu Meric, Kagan Kerman, Mehmet Özsöz

Turkish Journal of Medical Sciences

An amperometric biosensor based on a carbon paste electrode modified with horseradish peroxidase (HRP) is defined as a device for the quantitative and qualitative detection of oxidizable drugs. This paper demonstrates the advantages of using HRP as the biocatalyst in the in vitro detection of oxidizable drugs in the presence of hydrogen peroxide. Amperometric analysis and batch experiments were carried out in acetate buffer (pH 4.8) in the presence of hydrogen peroxide. Amperometry was performed by applying a potential of -0.1 V (vs. Ag/AgCl), in the presence of hydrogen peroxide and adding a drug which has an oxidizable group (OxG; …


Alterations Of Muc2 Mucin In Colorectal Adenocarcinoma, Nurten Aksoy, Anthony P. Corfield, Christos Paraskeva, David J. Thornton, John K. Sheehan Jan 2000

Alterations Of Muc2 Mucin In Colorectal Adenocarcinoma, Nurten Aksoy, Anthony P. Corfield, Christos Paraskeva, David J. Thornton, John K. Sheehan

Turkish Journal of Medical Sciences

MUC2 is a well-identified intestinal mucin, present predominantly in the small intestine and colon. It is known that pathological alterations in the expression and composition of this mucin occur in several serious diseases related to epithelial surfaces, e.g., carcinoma and colitis ulcerosa. In this study, our aim was to find out whether there are any specific alterations in the expression and secretion of MUC2 in an adenoma- adenocarcinoma sequence that has been established as an in vitro model (1,2). The adenoma-carcinoma sequence represents the first example of the malignant progression of human colonic adenoma cells in vitro (2,3). Using a …


A Case Of Partial Trisomy 13 Findings With 46,Xx,Der(7)T(7;13)(P22;Q31)Mat Karyotype, E. Ferda Perçi̇n, Y. Selma Sungu, Hati̇ce Ilgin Ruhi̇, Ayça Törel Ergur, Füsun Düzcan, İlhan Sezgi̇n Jan 2000

A Case Of Partial Trisomy 13 Findings With 46,Xx,Der(7)T(7;13)(P22;Q31)Mat Karyotype, E. Ferda Perçi̇n, Y. Selma Sungu, Hati̇ce Ilgin Ruhi̇, Ayça Törel Ergur, Füsun Düzcan, İlhan Sezgi̇n

Turkish Journal of Medical Sciences

No abstract provided.


Inguinal Endometriosis: A Report Of Two Cases And A Review Of The Literature, Ali̇ Kemal Uzunlar, Fahri̇ Yilmaz, Mehmet Yaldiz, Özden Kaya, Mehmet Özaydin Jan 2000

Inguinal Endometriosis: A Report Of Two Cases And A Review Of The Literature, Ali̇ Kemal Uzunlar, Fahri̇ Yilmaz, Mehmet Yaldiz, Özden Kaya, Mehmet Özaydin

Turkish Journal of Medical Sciences

No abstract provided.


Comparative Study Of Dopamine And Mannitol Effects On Renal Function During Cardiopulmonary Bypass By Using N-Acetyl-\Beta-D-Glucosaminidase Assay, Onur Dural, Asuman Özkara, Bi̇lge Çelebi̇oğlu, Meral Kanbak, Gönenç Ci̇li̇v, Ülkü Aypar Jan 2000

Comparative Study Of Dopamine And Mannitol Effects On Renal Function During Cardiopulmonary Bypass By Using N-Acetyl-\Beta-D-Glucosaminidase Assay, Onur Dural, Asuman Özkara, Bi̇lge Çelebi̇oğlu, Meral Kanbak, Gönenç Ci̇li̇v, Ülkü Aypar

Turkish Journal of Medical Sciences

The protective roles of low-dose dopamine and mannitol infusion in the renal function of patients undergoing cardiovascular surgery were compared in 36 patients by measuring urine N-acetyl-\beta-D- glucosaminidase activity, serum and urinary creatinine, blood urea nitrogen (BUN) levels and urine output. The patients were randomly selected and received a continuous infusion of dopamine, 3 µg/kg/min (Group I), mannitol, 1 mg/kg/h (Group II), no medication (Group III) before the induction of anaesthesia. Urine N- acetyl-\beta-D-glucosaminidase activities, serum and urinary creatinine and BUN were determined preoperatively after aortic cross- clamping, and on the first and second postoperative days. Changes in urine N-acetyl- …


Determination Of Free Fatty Acid Composition In Plasma Membranes Of Neutrophils In Diabetics, Mevlüt Sai̇t Keleş, Yaşar Demi̇r, İrfan Altuntaş, Zuhal Umudum, Ebubeki̇r Bakan Jan 2000

Determination Of Free Fatty Acid Composition In Plasma Membranes Of Neutrophils In Diabetics, Mevlüt Sai̇t Keleş, Yaşar Demi̇r, İrfan Altuntaş, Zuhal Umudum, Ebubeki̇r Bakan

Turkish Journal of Medical Sciences

Since frequent and serious infections occur in diabetic patients, the investigation of the function of neutrophils is of importance. Any change in the lipid composition of the plasma membrane could be one of the causes of these infections. In order to investigate this possibility and to determine any abnormalities, neutrophils and monocytes were separated by the Histopaque- 1119 method from the blood samples (20 ml) of 10 diabetic and 10 healthy persons. After disruption of the cells, membrane lipids and proteins were isolated. Free fatty acids of phospholipids in membrane lipids were isolated by hydrolysing with phospholipase B under an …


Auditory Brain Stem Response Screening For Hearing Loss In High Risk Neonates, Hülya Bi̇lgen, İpek Akman, Eren Özek, Sezer Külekçi̇, Rahmi̇ Örs, Kürşat Carman, Ferda Akdaş Jan 2000

Auditory Brain Stem Response Screening For Hearing Loss In High Risk Neonates, Hülya Bi̇lgen, İpek Akman, Eren Özek, Sezer Külekçi̇, Rahmi̇ Örs, Kürşat Carman, Ferda Akdaş

Turkish Journal of Medical Sciences

Hearing screening of neonates is the key to preventing the most severe consequences of congenital hearing loss. In this paper, the auditory brain stem responses (ABR) of neonates at high risk for hearing impairment at Marmara University Hospital Neonatal Intensive Care Unit are reported. One hundred fifty-four high-risk neonates underwent screening by ABR carried out according to the US Joint Committee on Hearing 1994 Position Statement. One hundred and fourteen of them passed the first ABR test while 40 patients failed. The number of patients with sensorineural and conductive hearing deficit was 5 and 35, respectively. Fifteen of the infants …


High-Dose Intravenous Immunoglobulin Treatment In Intractable Childhood Epilepsy, Nedret Uran, Gül Serdaroğlu, Erki̇n Serdaroğlu, Sema Kalkan, Tuğrul Özcan Jan 2000

High-Dose Intravenous Immunoglobulin Treatment In Intractable Childhood Epilepsy, Nedret Uran, Gül Serdaroğlu, Erki̇n Serdaroğlu, Sema Kalkan, Tuğrul Özcan

Turkish Journal of Medical Sciences

Rationale: Intractable childhood epilepsy is characterised by convulsions, which are resistant to treatment with adequate dosage, combination and duration of appropriate anticonvulsant drugs. Many clinical and experimental studies support the role of the immune mechanism in the pathogenesis of childhood epilepsy. The purpose of the present study is to ascertain the possible efficacy of intravenous immunoglobulin in the treatment of intractable childhood epilepsy. Methods: The children aged 4-8 years suffering from intractable childhood epilepsy were treated with high-dose intravenous immunoglobulin (400 mg/kg) 5 times in the first week, on the 15th and 30th days. The treatments were repeated every 4 …


Detection Of The Sry Gene In A 46,Xy Phenotypic Female By The Pcr-Sscp Method, M. Emi̇n Erdal, I. Ömer Barlas Jan 2000

Detection Of The Sry Gene In A 46,Xy Phenotypic Female By The Pcr-Sscp Method, M. Emi̇n Erdal, I. Ömer Barlas

Turkish Journal of Medical Sciences

No abstract provided.


Nitric Oxide In Chronic Liver Disease, Güldal Kirkali, Semra Gezer, Nurcan Umur, Mehmet Ali̇ Özcan, Ethem Tankurt Jan 2000

Nitric Oxide In Chronic Liver Disease, Güldal Kirkali, Semra Gezer, Nurcan Umur, Mehmet Ali̇ Özcan, Ethem Tankurt

Turkish Journal of Medical Sciences

The formation of nitric oxide (NO), a free radical, increases in liver disease, where the L-arginine-nitric oxide (L- arg-NO) pathway is activated by the increased levels of cytokines and endotoxins. In this study, we investigated the relationship between the L-arg-NO pathway and chronic active hepatitis and cirrhosis, which are classified as chronic liver disease. We determined the serum levels of nitrite and nitrate, the end products of the L-arg-NO pathway, in patients with chronic liver disease and compared them with the control group levels. Total nitrite produced by the reduction of nitrate to nitrite in the presence of nitrate reductase …