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Full-Text Articles in Medicine and Health Sciences

Adjunctive Use Of Laser Biostimulation With Nonsurgical Periodontal Therapy: A Split Mouth, Randomized, Case-Control Study In Diabetic And Nondiabetic Periodontitispatients, Funda Akansel, Umur Sakallioğlu, Müge Lütfi̇oğlu, Feyza Otan Özden, Adil Karadağ Jan 2024

Adjunctive Use Of Laser Biostimulation With Nonsurgical Periodontal Therapy: A Split Mouth, Randomized, Case-Control Study In Diabetic And Nondiabetic Periodontitispatients, Funda Akansel, Umur Sakallioğlu, Müge Lütfi̇oğlu, Feyza Otan Özden, Adil Karadağ

Turkish Journal of Medical Sciences

Laser biostimulation therapy (LBT) is suggested to have positive effects on periodontal healing. This study evaluatedLBT with nonsurgical periodontal therapy (NSPT) in diabetes mellitus (DM) and systemic health (SH) conditions.Materials and methods: Thirty periodontitis patients (15 with DM and 15 with SH) were included in the study, which had a split-mouthdesign, by applying LBT in the mouth of the same systemic condition. Thus, 4 study groups were formed, as 1) NSPT – DM: NSPT alonein DM, 2) NSPT + LBT – DM: NSPT + LBT application in DM, 3) NSPT – SH: NSPT alone in SH, and 4) NSPT + …


Protective Effects Of Swimming Exercises And Metformin On Cardiac And Aortic Damage Caused By A High-Fat Diet In Obese Rats With Type 2 Diabetes, By Regulating The Bcl2/Bax Signaling Pathway, Ebru Özüdoğru, Emrah Atay, Mehtap Savran, Hali̇l Aşci, Özlem Özmen, Şenay Topsakal Dec 2023

Protective Effects Of Swimming Exercises And Metformin On Cardiac And Aortic Damage Caused By A High-Fat Diet In Obese Rats With Type 2 Diabetes, By Regulating The Bcl2/Bax Signaling Pathway, Ebru Özüdoğru, Emrah Atay, Mehtap Savran, Hali̇l Aşci, Özlem Özmen, Şenay Topsakal

Turkish Journal of Medical Sciences

Background/aim: Due to the increasing mortality and morbidity rates in diabetes mellitus (DM), which is one of the biggest health problems of our age, many treatment modalities are still being tried. The positive effects of metformin (MET) and physical exercise (EXE) on the pathophysiology of diabetes are well known. In this study, it was aimed to detail these positive effects of MET and EXE in combination on the basis of inflammation, apoptosis mechanisms, and endogen nesfatin-1 (NES-1) synthesis. Materials and methods: Twenty-seven type 2 DM (DM-2) male Wistar Albino rats were divided into 4 groups, as the high-fat diet (HFD), …


Comprehensive Comparison Of Clinicoradiological, Laboratory, And Prognostic Factors Of Community-Acquired Pneumonia In Diabetic And Nondiabetic Hospitalized Patients, Seyyed Hamid Hashemi, Fatemeh Saki, Shiva Borzouei, Rashed Bawand, Alireza Soltanian Dec 2023

Comprehensive Comparison Of Clinicoradiological, Laboratory, And Prognostic Factors Of Community-Acquired Pneumonia In Diabetic And Nondiabetic Hospitalized Patients, Seyyed Hamid Hashemi, Fatemeh Saki, Shiva Borzouei, Rashed Bawand, Alireza Soltanian

Turkish Journal of Medical Sciences

Background/aim: Community-acquired pneumonia (CAP) is one of the leading infectious causes of mortality, and diabetes mellitus is a globally prevalent disease. Consequently, the cooccurrence of these two disorders can be common and create challenging medical conditions. Therefore, it was aimed to compare the various aspects of CAP in diabetic and nondiabetic patients, in order to have a comprehensive and comparative picture of the differences. Materials and methods: In this cross-sectional study, CAP patients with and without diabetes were assessed for clinicoradiological signs, laboratory features, disease severity, and pneumonia outcomes. Results: Analyzed herein were 172 CAP patients (77 had diabetes and …


Evaluation Of Chronic Pruritus And Associated Skin Findings In Patients With Diabetes Mellitus, Fatma Avci Merdi̇n, Ahmet Taha Aydemi̇r, Fatma Nur Korkmaz, Fatma Tuğçe Şah Ünal, Asena Gökçay Canpolat, Ayşe Öktem, Özgür Demi̇r, Mustafa Şahi̇n, Rifat Emral, Murat Fai̇k Erdoğan, Sevi̇m Güllü, Aydin Vedi̇a Gedi̇k, Peli̇n Koçyi̇ği̇t, Demet Çorapçioğlu Oct 2023

Evaluation Of Chronic Pruritus And Associated Skin Findings In Patients With Diabetes Mellitus, Fatma Avci Merdi̇n, Ahmet Taha Aydemi̇r, Fatma Nur Korkmaz, Fatma Tuğçe Şah Ünal, Asena Gökçay Canpolat, Ayşe Öktem, Özgür Demi̇r, Mustafa Şahi̇n, Rifat Emral, Murat Fai̇k Erdoğan, Sevi̇m Güllü, Aydin Vedi̇a Gedi̇k, Peli̇n Koçyi̇ği̇t, Demet Çorapçioğlu

Turkish Journal of Medical Sciences

Background/aim: To explore the dermatological lesions associated with chronic pruritus in patients who were followed up at our clinic for type 1 and type 2 diabetes mellitus (DM). Materials and methods: The study population consisted of 249 patients with DM, who presented to the endocrinology clinic at Ankara University Faculty of Medicine between January 2022, and March 2022, regardless of whether they had reported experiencing pruritus symptoms. The visual analog scale and 5-D itch scale were used to determine the severity of itching in patients. Dermatological examination findings were also evaluated. Results: Of the 249 patients with DM, mean duration …


Characteristics Of Diabetes Mellitus Patients In Turkey: An Analysis Of National Electronic Health Records, Mustafa Mahi̇r Ülgü, Kemal Hakan Gülkesen, Abdullah Akünal, Mustafa Okan Ayvali, Neşe Zayi̇m, Şuayip Bi̇ri̇nci̇, Mustafa Kemal Balci Jan 2023

Characteristics Of Diabetes Mellitus Patients In Turkey: An Analysis Of National Electronic Health Records, Mustafa Mahi̇r Ülgü, Kemal Hakan Gülkesen, Abdullah Akünal, Mustafa Okan Ayvali, Neşe Zayi̇m, Şuayip Bi̇ri̇nci̇, Mustafa Kemal Balci

Turkish Journal of Medical Sciences

Background/aim: It was estimated that there were 537 million people with diabetes mellitus in 2021, representing 10.5% of the global adult population. Diabetes prevalence in Turkey is 13.5%, according to a meta-analysis and 17.3% according to a recent study. Although the primary purpose of Electronic Health Records (EHRs) is clinical, researchers can use them to conduct epidemiologic investigations. This study aims to document the prevalence of diabetes and to evaluate the healthcare utilization of people with diabetes compared to the people without diabetes, based on national EHR. Methods: Only people over 14 years old were included in the analysis. Our …


Modulatory Effect Of Resveratrol And Melatonin On Natural Killer Cell Activity And Adrenomedullin In Diabetic Rats, Fati̇h Özçeli̇k, Fati̇h Hacimustafaoğlu, Alpaslan Tanoğlu Jan 2022

Modulatory Effect Of Resveratrol And Melatonin On Natural Killer Cell Activity And Adrenomedullin In Diabetic Rats, Fati̇h Özçeli̇k, Fati̇h Hacimustafaoğlu, Alpaslan Tanoğlu

Turkish Journal of Medical Sciences

Background/aim: Epidemiological evidence suggests that diabetes poses a high risk for many chronic diseases, especially cardiovascular diseases, and cancer by stimulating many inflammatory and immunological pathogenic mediators and affecting natural killer (NK)-cell activity. In this study, the effects of melatonin and resveratrol on IL-6, TNF-alpha, oxidant/antioxidant capacity, NK-cell activity, and mid-regional proadrenomedullin (MR-proADM) levels of diabetic rats were investigated. Materials and methods: In the study, 28 Sprague Dawley rats were randomly divided into the control group (group I) and 3 streptozotocin- induced diabetes mellitus (DM) groups (group II, III, and IV), each group consisting of 7 rats. Five mg/kg/day melatonin …


Pancreas And Kidney Changes In Type 2 Diabetes Patients: The Role Of Diffusion-Weightedimaging, Mehmet Hamdi̇ Şahan, Adnan Özdemi̇r, Neşe Asal, Mi̇race Yasemi̇n Karadeni̇z Bi̇lgi̇li̇, Adi̇l Doğan, Aşkin Güngüneş Jan 2021

Pancreas And Kidney Changes In Type 2 Diabetes Patients: The Role Of Diffusion-Weightedimaging, Mehmet Hamdi̇ Şahan, Adnan Özdemi̇r, Neşe Asal, Mi̇race Yasemi̇n Karadeni̇z Bi̇lgi̇li̇, Adi̇l Doğan, Aşkin Güngüneş

Turkish Journal of Medical Sciences

Background/aim: The aim of this study was to compare renal and pancreatic apparent diffusion-coefficient (ADC) values of diabetic patients and control subjects and to examine their potential association with several diabetes-related clinical parameters. Materials and methods: A total of 80 sex- and age-matched patients were included in the study. Of them, 40 were patients with type 2 diabetes and 40 were nondiabetic participants. Abdominal diffusion-weighted MRIs of both groups were retrospectively reviewed. Diabetes-related clinical parameters were recorded. Results: The difference between the mean ADC values of the patient group and the control group was significant (p = 0.012). It was …


Fatty Acid-Binding Protein-4 As A Biomarker Predicting Acromegaly-Associated Diabetesmellitus, Sema Hepşen, Pinar Akhanli, Hakan Düğer, Murat Çalapkulu, Beki̇r Uçan, Muhammed Erkam Sencar, Davut Sakiz, İlknur Öztürk Ünsal, Seyi̇t Murat Bayram, Mustafa Özbek, Erman Çakal Jan 2021

Fatty Acid-Binding Protein-4 As A Biomarker Predicting Acromegaly-Associated Diabetesmellitus, Sema Hepşen, Pinar Akhanli, Hakan Düğer, Murat Çalapkulu, Beki̇r Uçan, Muhammed Erkam Sencar, Davut Sakiz, İlknur Öztürk Ünsal, Seyi̇t Murat Bayram, Mustafa Özbek, Erman Çakal

Turkish Journal of Medical Sciences

Background/aim: The known pathogenesis of diabetes mellitus (DM) in acromegaly is mainly based on growth hormone (GH) and insulin-like growth factor-1 (IGF-1) excess. Fatty acid-binding protein 4 (FABP-4), a novel adipokine, is found to induce insulin resistance and type 2 DM. We aimed to investigate the possible effect of FABP-4 on glucose metabolism in patients with acromegaly. Materials and methods: This case-control study included 28 patients newly diagnosed with acromegaly and 57 healthy volunteers. The patients with acromegaly were classified according to their glycemic status as with DM, prediabetes, and normal glucose tolerance. Anthropometric measurements, laboratory test results, and FABP-4 …


Assessment Of Erythrocyte Morphology In Patients With Type 2 Diabetes Mellitus: A Pilotstudy Of Electron Microscopy-Based Analysis In Relation To Healthy Controls, Tülay Mortaş, Şenay Arikan Durmaz, Şaban Cem Sezen, Yasemi̇n Savranlar Jan 2021

Assessment Of Erythrocyte Morphology In Patients With Type 2 Diabetes Mellitus: A Pilotstudy Of Electron Microscopy-Based Analysis In Relation To Healthy Controls, Tülay Mortaş, Şenay Arikan Durmaz, Şaban Cem Sezen, Yasemi̇n Savranlar

Turkish Journal of Medical Sciences

Background/aim: The present study aimed to assess erythrocyte morphology in newly diagnosed type 2 diabetes mellitus patients using scanning electron microscopy. Materials and methods: In total, 30 patients admitted to endocrine outpatient clinics were included in the study. The patients were divided into two groups according to their fasting blood glucose levels: type 2 diabetes mellitus (n = 15, fasting blood glucose levels ≥ 126 mg/dL) and control (n = 15, fasting blood glucose levels < 99 mg/dL). The patient's demographic characteristics, haemoglobin A1c levels, and scanning electron microscopy findings regarding erythrocyte morphology were recorded. Results: There was no significant difference between the control and type 2 diabetes mellitus group in terms of the participants' age (51.13 ± 8.53 vs. 50.33 ± 8.72 years, p = 0.8) and the male/female ratio (9/6 vs. 9/6). In the control group, discocytes were abundant, echinocytes were rare, and spherocytes were absent. On the other hand, discocytes were less common and echinocyte-shaped erythrocytes were more common in the type 2 diabetes mellitus group than in the control group. In addition, spherocytes were detected in the type 2 diabetes mellitus group. Moreover, the diameter of discocytes was significantly lower (p = 0.014), and blood glucose and haemoglobin A1c levels were significantly higher (p < 0.05 for both) in the type 2 diabetes mellitus group than in the control group. Conclusion: Our findings indicate that high glucose levels in type 2 diabetes mellitus patients lead to significant alterations in erythrocyte morphology, including decreased erythrocyte deformability and the formation of echinocytes and spherocytes due to eryptosis. The possibility of decreased erythrocyte deformability due to excessive eryptosis may disturb microcirculation in newly diagnosed, treatment-naïve type 2 diabetes mellitus patients who do not have any complications.


Validity And Reliability Of The Turkish Version Of The Michigan Neuropathy Screeninginstrument, Duygu Aktar Reyhani̇oğlu, Süleyman Cem Adiyaman, Murat Bektaş, Onur Bulut, Başak Özgen Saydam, Firat Bayraktar, Bi̇lge Kara Jan 2020

Validity And Reliability Of The Turkish Version Of The Michigan Neuropathy Screeninginstrument, Duygu Aktar Reyhani̇oğlu, Süleyman Cem Adiyaman, Murat Bektaş, Onur Bulut, Başak Özgen Saydam, Firat Bayraktar, Bi̇lge Kara

Turkish Journal of Medical Sciences

Background/aim: The aim of this study was to demonstrate the validity and reliability of the Turkish version of the Michigan Neuropathy Screening Instrument (MNSI-TR). Materials and methods: The study included 127 patients aged 45-76 years who were previously diagnosed with type 1 or 2 diabetes. Stability of the instrument was assessed by intraclass correlation coefficient. Reliability of the MNSI-TR was assessed using the Kuder- Richardson formula 20 test, item-total correlations, and floor/ceiling effect. Validity was evaluated with receiver operating characteristic curve analysis. A logistic regression model was used to determine to what degree the MNSI-TR explain nerve conduction study (NCS) …


Determining The Insulin Secretion Potential For Certain Specific G-Protein Coupled Receptors In Min6 Pancreatic Beta Cells, Hasan Gençoğlu, Kazi̇m Şahi̇n, Peter M. Jones Jan 2019

Determining The Insulin Secretion Potential For Certain Specific G-Protein Coupled Receptors In Min6 Pancreatic Beta Cells, Hasan Gençoğlu, Kazi̇m Şahi̇n, Peter M. Jones

Turkish Journal of Medical Sciences

Background/aim: The polypeptide hormone insulin is essential for the maintenance of whole-body fuel homeostasis, and defects in insulin secretion and/or action are associated with the development of type 1 and type 2 diabetes. The aim of this study was to assess the role of some G-protein coupled receptors (GPCRs), GPR54, GPR56, and GPR75, and cannabinoid receptors CB1R and CB2R, in the regulation of pancreatic ß-cell function.Materials and methods: Insulin secretion from mouse insulinoma ß-cell line (MIN6) monolayers was assessed via insulin radioimmu-noassay (RIA). Reverse transcription-polymerase chain reaction (RT-PCR) was used to assess the expression of some specific GPCRs and the …


Effects Of Cinnamic Acid On Complications Of Diabetes, Hati̇ce Gül Anlar, Merve Bacanli, Tuğbagül Çal, Sevtap Aydin, Nuray Ari, Ülkü Ündeğer Bucurgat, Ari̇f Ahmet Başaran, Ayşe Nurşen Başaran Jan 2018

Effects Of Cinnamic Acid On Complications Of Diabetes, Hati̇ce Gül Anlar, Merve Bacanli, Tuğbagül Çal, Sevtap Aydin, Nuray Ari, Ülkü Ündeğer Bucurgat, Ari̇f Ahmet Başaran, Ayşe Nurşen Başaran

Turkish Journal of Medical Sciences

Background/aim: Diabetes mellitus (DM) is a major health problem worldwide. Cinnamic acid (CA) and its derivatives are synthesized in plants and increasing attention has been given to them in recent years due to the high number of beneficial health properties attributed to their consumption. The aim of this study was to investigate the effects of CA on streptozotocin-induced diabetes in Wistar albino rats. Materials and methods: DNA damage was evaluated in the blood, liver, and kidney cells of rats by the alkaline comet assay. Oxidative stress parameters such as catalase, superoxide dismutase, glutathione reductase, glutathione-S-transferase, and glutathione peroxidase activities and …


Angiostatin Levels In Diabetes Mellitus Patients Receiving Insulin Treatment: Associations With Laboratory Findings, Comorbidities, And Medications, İsmai̇l Ertürk, Erdi̇m Sertoğlu, Fati̇h Yeşi̇ldal, Ramazan Acar, Taner Özgürtaş, Kenan Sağlam Jan 2018

Angiostatin Levels In Diabetes Mellitus Patients Receiving Insulin Treatment: Associations With Laboratory Findings, Comorbidities, And Medications, İsmai̇l Ertürk, Erdi̇m Sertoğlu, Fati̇h Yeşi̇ldal, Ramazan Acar, Taner Özgürtaş, Kenan Sağlam

Turkish Journal of Medical Sciences

Background/aim: The clinical effect of angiostatin in diabetes mellitus (DM) patients receiving insulin is a meaningful gap in the literature. In this study, we aimed to show the levels and the clinical significance of angiostatin in DM patients receiving insulin. Materials and methods: This is a case-control study. Serum angiostatin levels were determined by ELISA. A total of 83 people consisting of healthy subjects (n = 36) and patients with a diagnosis of DM receiving insulin therapy (n = 47) were included in this study. Results: The mean angiostatin levels of the DM group were significantly higher than those of …


Attitudes, Wishes, And Needs Of Diabetes Patients And Their Relatives: Turkish Data Fromthe Dawn2 Study, İlhan Tarkun, Suzan Dumanli Özgöksu Jan 2017

Attitudes, Wishes, And Needs Of Diabetes Patients And Their Relatives: Turkish Data Fromthe Dawn2 Study, İlhan Tarkun, Suzan Dumanli Özgöksu

Turkish Journal of Medical Sciences

Background/aim: The DAWN2 (Diabetes Attitudes, Wishes, and Needs) study was conducted in order to ascertain the wishes, needs, and attitudes of diabetes patients, their relatives, and healthcare professionals. The study was conducted across 17 countries, including Turkey, and its objective was to introduce policies that could successfully meet these requirements. In this article, the needs, wishes, and attitudes of diabetes patients and their relatives in Turkey are compared with those from other countries. Materials and methods: Eighty patients with type 1 diabetes, 426 patients with type 2 diabetes, and 126 relatives of patients with diabetes were included in the study. …


Is There Any Difference In Tetanus Igg Levels Of Diabetic Patientswith Respect To The Presence Of Foot Ulcers?, Fati̇h Teki̇n, Mehmet Sürmeli̇, Zeynep Çi̇zmeci̇, Özlem Teki̇n, Ergi̇n Işik, Ömer Faruk Taner, Derun Taner Ertuğrul Jan 2017

Is There Any Difference In Tetanus Igg Levels Of Diabetic Patientswith Respect To The Presence Of Foot Ulcers?, Fati̇h Teki̇n, Mehmet Sürmeli̇, Zeynep Çi̇zmeci̇, Özlem Teki̇n, Ergi̇n Işik, Ömer Faruk Taner, Derun Taner Ertuğrul

Turkish Journal of Medical Sciences

Background/aim: The aim of this study was to reveal the tetanus immunization status of diabetic patients and to determine whether diabetic patients with foot ulcers have different TIG levels. Materials and methods: A cross-sectional study was designed that included diabetic patients with foot ulcers (n = 30) and diabetic patients without ulcers (n = 30). The groups were compared for serum TIG levels along with total serum protein, albumin, C-reactive protein (CRP), and total immunoglobulin G (Ig G). Results: For diabetic patients without foot ulcers, 17 of 30 (56.6%) patients were found to have nonprotective TIG levels whereas for diabetic …


Genotypes And Virulence Factors Of Candida Species Isolated From Oralcavities Of Patients With Type 2 Diabetes Mellitus, Soley Arslan, Ayşe Nedret Koç, Ahmet Ercan Şekerci̇, Fati̇h Tanriverdi̇, Hafi̇ze Sav, Gonca Aydemi̇r, Hali̇t Di̇ri̇ Jan 2016

Genotypes And Virulence Factors Of Candida Species Isolated From Oralcavities Of Patients With Type 2 Diabetes Mellitus, Soley Arslan, Ayşe Nedret Koç, Ahmet Ercan Şekerci̇, Fati̇h Tanriverdi̇, Hafi̇ze Sav, Gonca Aydemi̇r, Hali̇t Di̇ri̇

Turkish Journal of Medical Sciences

Background/aim: This study compared the genotypes and virulence factors of Candida species isolated from oral cavities of healthy individuals and patients with diabetes mellitus (DM). Materials and methods: A total of 142 healthy individuals and 73 diabetic patients participated in this study. Study populations were classified into 4 groups as follows: Group I " Healthy, without caries; Group II " Healthy, with caries; Group III " DM, with caries; Group IV " DM, without caries. Diabetic patients' blood glucose and hemoglobin A1c concentrations were determined. Identification of Candida species was performed with conventional methods. Biofilm production, proteinase, phospholipase, and esterase …


Effect Of Resveratrol On Resistin And Apelin Gene Expressions In Adipose Tissue Of Diabetic Rats, Sadegh Zarei, Massoud Saidijam, Jamshid Karimi, Reza Yadegarazari, Azam Rezaei Farimani, Solmazsaadat Hosseini-Zijood, Mohammad Taghi Goodarzi Jan 2016

Effect Of Resveratrol On Resistin And Apelin Gene Expressions In Adipose Tissue Of Diabetic Rats, Sadegh Zarei, Massoud Saidijam, Jamshid Karimi, Reza Yadegarazari, Azam Rezaei Farimani, Solmazsaadat Hosseini-Zijood, Mohammad Taghi Goodarzi

Turkish Journal of Medical Sciences

Background/aim: Adipose tissue plays a major role in glucose homeostasis. Dietary antioxidants such as resveratrol (RSV) may offer some protection against the early stage of diabetes mellitus and the development of complications. The present study investigated the effects of RSV on biochemical parameters and resistin and apelin gene expressions in adipose tissue of rats with type 2 diabetes. Materials and methods: Diabetes was induced using a single dose of streptozotocin + nicotinamide. Three groups of diabetic rats were treated with different doses of RSV (1, 5, and 10 mg/kg body weight per day). Oxidative status, serum biochemical parameters, insulin, and …


Central Corneal Thickness In Type Ii Diabetes Mellitus: Is It Relatedto The Severity Of Diabetic Retinopathy?, Okan Toygar, Selçuk Sizmaz, Aysel Peli̇t, Baha Toygar, Özge Yabaş Kiziloğlu, Yonca Akova Jan 2015

Central Corneal Thickness In Type Ii Diabetes Mellitus: Is It Relatedto The Severity Of Diabetic Retinopathy?, Okan Toygar, Selçuk Sizmaz, Aysel Peli̇t, Baha Toygar, Özge Yabaş Kiziloğlu, Yonca Akova

Turkish Journal of Medical Sciences

Background/aim: To compare the central corneal thickness (CCT) of type II diabetes mellitus patients with age- and sex-matched healthy subjects and to determine the association of the severity of diabetic retinopathy and CCT. Materials and methods: Type II diabetes mellitus patients without retinopathy, with nonproliferative retinopathy, and with proliferative retinopathy were organized as the three subgroups of the study group, and an age- and sex-matched control group was formed. All subjects underwent full ophthalmological examination and CCT measurement with ultrasonographic pachymetry. CCT values were compared between diabetic and healthy subjects and between the three diabetic subgroups. Correlation analysis was performed …


Stress-Responsive Factor Regulation In Patients Suffering From Type 2 Diabetes And Myocardial Infarction, Sobia Mushtaq, Tahir Ali, Farhana Altaf, Muhammad Abdullah, Iram Murtaza Jan 2015

Stress-Responsive Factor Regulation In Patients Suffering From Type 2 Diabetes And Myocardial Infarction, Sobia Mushtaq, Tahir Ali, Farhana Altaf, Muhammad Abdullah, Iram Murtaza

Turkish Journal of Medical Sciences

Pro-free radical oxidative stresses, as well as regulatory factors, are believed to be the key players in the development of diabetes and heart-related disorders such as myocardial infarction. The aim of the present study was to highlight the role of oxidative stress-responsive factors (reactive oxygen species [ROS], super oxide dismutase [SOD], and calpain-1) in type 2 diabetes and myocardial infarction. Materials and methods: A total of 100 type 2 diabetes patients with myocardial infarction and 50 normal individuals were selected for this analysis. The levels of ROS and activities of SOD in the serum were determined. Serum calpain-1 expression was …


Salivary Glucose And Antioxidant Defense Markers In Type Ii Diabetes Mellitus, Sayeeda Mussavira, Mala Dharmalingam, Bindhu Omana Sukumaran Jan 2015

Salivary Glucose And Antioxidant Defense Markers In Type Ii Diabetes Mellitus, Sayeeda Mussavira, Mala Dharmalingam, Bindhu Omana Sukumaran

Turkish Journal of Medical Sciences

To evaluate salivary antioxidant defense markers, their correlation with salivary glucose, and glycemic status in type II diabetes mellitus (DM). Materials and methods: The study included 53 diabetic patients and 40 healthy subjects. Salivary glucose, blood glucose, and uric acid (UA) were determined by specific enzymatic methods. Total antioxidant activity (AOA), glutathione (GSH), catalase (CAT), superoxide dismutase (SOD), and total protein were determined spectrophotometrically. Results: Salivary UA (3.12 vs. 1.89 mg/dL), GSH (47 vs. 11.92 µg/mL), and total protein (375.12 vs. 202.23 mg/dL) were significantly higher (P < 0.001; r = 0.455, 0.735, 0.498 respectively) and AOA (653.1 vs. 897.3 µmol/L) was significantly lower in the DM group (P < 0.001, r = -0.431) compared to healthy controls. Among the antioxidant enzymes, CAT was significantly lower (1214 vs. 9468.9 kat) in the DM group (P < 0.001, r = -0.886). Spearman correlation analyses within the diabetic group showed a strong positive association between salivary glucose and blood glucose (P < 0.001, r = 0.9), salivary glucose and GSH, and salivary glucose and UA. Salivary glucose showed a negative correlation with AOA and CAT (P = 0.008, r = -0.447) in the diabetic group. Conclusion: Findings of this study, showing a strong correlation between salivary glucose and blood glucose as well as changes in antioxidant components in the DM group, suggest that saliva can be used for the diagnosis and management of DM.


Osteoprotegerin As A Marker Of Atherosclerosis In Type 1 And Type 2 Diabetic Patients, Çi̇ğdem Alkaç, Burak Alkaç, Feray Akbaş, Hale Aral, Yeşi̇m Karagöz, Esma Güldal Altunoğlu Jan 2015

Osteoprotegerin As A Marker Of Atherosclerosis In Type 1 And Type 2 Diabetic Patients, Çi̇ğdem Alkaç, Burak Alkaç, Feray Akbaş, Hale Aral, Yeşi̇m Karagöz, Esma Güldal Altunoğlu

Turkish Journal of Medical Sciences

Background/aim: The aim of this study was to investigate the availability of osteoprotegerin (OPG) as a marker of atherosclerosis and compare serum OPG levels with ankle-brachial index (ABI) in diabetic patients. Materials and methods: A total of 31 type 1 and 31 type 2 diabetic patients without macrovascular complications and 20 healthy volunteers were included. Serum OPG levels and ABI were measured. Results: The duration of diabetes was significantly higher in type 1 diabetics than in type 2, although there was no significant difference between mean HbA1c levels. There was a weak and inverse correlation between OPG and atherosclerosis in …


Evaluation Of Outer Hair Cell Function And Medial Olivocochlear Efferent System In Patients With Type Ii Diabetes Mellitus, Hayri̇ye Karabulut, İsmai̇l Karabulut, Muharrem Dağli, Yildirim Ahmet Bayazit, Şule Bi̇len, Yusuf Aydin, Serdar Güler, İsmet Bayramoğlu Jan 2014

Evaluation Of Outer Hair Cell Function And Medial Olivocochlear Efferent System In Patients With Type Ii Diabetes Mellitus, Hayri̇ye Karabulut, İsmai̇l Karabulut, Muharrem Dağli, Yildirim Ahmet Bayazit, Şule Bi̇len, Yusuf Aydin, Serdar Güler, İsmet Bayramoğlu

Turkish Journal of Medical Sciences

This study was designed to investigate the function of outer hair cells and medial olivocochlear efferents in type II diabetes mellitus (DM). Materials and methods: There were 50 patients with type II DM and 51 age- and sex-matched healthy controls included in the study. Both groups were compared in terms of transient evoked otoacoustic emissions (TEOAEs), distortion product otoacoustic emissions (DPOAEs), and contralateral suppression of TEOAE. Results: Pure tone thresholds of the patients with type II DM were significantly higher than in the controls (P < 0.05). The TEOAE amplitudes at 1 kHz and at 1.5, 2, 3, 4, and 6 kHz signal-to-noise ratio amplitudes on DPOAE testing were significantly lower in the patients than controls (P < 0.05). There was no significant difference between the type II DM and control groups regarding contralateral suppression test results of TEOAEs. Conclusion: Type II DM seems to impact the auditory system at the cochlear level by affecting the functions of outer hair cells, and it results in elevation of the thresholds on audiometry and a decrease in the amplitudes of otoacoustic emissions.


Effects Of Phenolic Acids On Gastrointestinal Smooth Muscle Complications In Streptozotocine-Induced Diabetic Rats, Nurcan Bektaş, Yusuf Öztürk Jan 2012

Effects Of Phenolic Acids On Gastrointestinal Smooth Muscle Complications In Streptozotocine-Induced Diabetic Rats, Nurcan Bektaş, Yusuf Öztürk

Turkish Journal of Medical Sciences

To identify the effects of antioxidants on gastrointestinal smooth muscle complications in 6-week streptozotocine (STZ)-induced diabetic rats. Materials and methods: The following steps were carried out: 1. Three weeks after STZ injection, saline and 10 mg/kg p-OH benzoic, protocatechic, and gallic acids were separately administered to the rat groups every day for 3 weeks. 2. The responses of the fundus and ileum to agonists were recorded using isolated organ bath experiments. Results: Diabetic smooth muscle complications developed in the diabetic rats. The responses of the ileum to acetylcholine increased whereas the responses of the fundus to serotonine decreased in the …


Hyperactivation Of The Hypothalamo-Pituitary-Adrenocortical Axis In Streptozotocin Diabetic Rats: Effect Of Tinospora Cordifolia (Willd.) And Insulin Therapy, Nagaraja Puranik, Sheela Devi Devi, Kararshaha Kammar Jan 2012

Hyperactivation Of The Hypothalamo-Pituitary-Adrenocortical Axis In Streptozotocin Diabetic Rats: Effect Of Tinospora Cordifolia (Willd.) And Insulin Therapy, Nagaraja Puranik, Sheela Devi Devi, Kararshaha Kammar

Turkish Journal of Medical Sciences

In the present study, we investigated the extent to which changes in corticosterone level and food and water intake behavior occur in diabetes and explored the effect of Tinospora cordifolia extracts and insulin therapy in streptozotocin-induced diabetic rats. Materials and methods: Female albino rats of the inbred Wistar strain (body weight: 180-210 g) were used in this study. Experimental diabetes was induced by injecting freshly prepared streptozotocin once at the dose of 55 mg/kg body weight intravenously in 0.1 M citrate buffer, pH 4.5. The drug was administered orally for 10 days and 30 days in different groups containing 6 …


Dysregulation Of Nitric Oxide Synthase Activity And Bcl-2 And Caspase-3 Gene Expressions In Renal Tissue Of Streptozotocin-Induced Diabetic Rats, Hüseyi̇n Aktuğ, Vi̇ldan Bozok Çeti̇ntaş, Buket Kosova, Fati̇h Oltulu, Şi̇ri̇n Bakti Demi̇ray, Türker Çavuşoğlu, Saadet Özen Akarca, Altuğ Yavaşoğlu Jan 2012

Dysregulation Of Nitric Oxide Synthase Activity And Bcl-2 And Caspase-3 Gene Expressions In Renal Tissue Of Streptozotocin-Induced Diabetic Rats, Hüseyi̇n Aktuğ, Vi̇ldan Bozok Çeti̇ntaş, Buket Kosova, Fati̇h Oltulu, Şi̇ri̇n Bakti Demi̇ray, Türker Çavuşoğlu, Saadet Özen Akarca, Altuğ Yavaşoğlu

Turkish Journal of Medical Sciences

To evaluate the effects of diabetes on nitric oxide synthase (NOS) activity and on gene expressions of B-cell lymphoma protein 2 (Bcl-2) and caspase-3 in the renal tissues of streptozotocin (STZ)-induced rats. Materials and methods: Twenty rats were analyzed in 2 equally distributed groups of healthy controls and STZ-induced diabetic rats. Rats with blood glucose levels of >=250 mg/dL were considered diabetic. Renal tissue sections were analyzed histomorphologically and immunohistochemically. Gene expressions of caspase-3 and Bcl-2 were evaluated by real-time quantitative polymerase chain reaction. Results: Bcl-2 expression significantly decreased in the diabetic group, both at the gene and protein level. …


The Role Of Hba1c As A Screening And Diagnostic Test For Diabetes Mellitus In Ankara, Zeynep Gi̇ni̇ş, Gülfer Öztürk, Rana Sirmali, Ali̇ Yalçindağ, Yakup Dülgeroğlu, Tuncay Deli̇başi, Namik Deli̇baş Jan 2012

The Role Of Hba1c As A Screening And Diagnostic Test For Diabetes Mellitus In Ankara, Zeynep Gi̇ni̇ş, Gülfer Öztürk, Rana Sirmali, Ali̇ Yalçindağ, Yakup Dülgeroğlu, Tuncay Deli̇başi, Namik Deli̇baş

Turkish Journal of Medical Sciences

This study investigated the value of HbA1c as a screening and diagnostic test for diabetes mellitus (DM) in high-risk Turkish individuals. Materials and methods: A total of 295 participants were successfully screened. Patients were divided into 4 groups based on their oral glucose tolerance test results, according to criteria put forth by the American Diabetes Association; 120 (40.7%) had normoglycemia, 44 (14.9%) had DM, 62 (21%) had impaired fasting glucose, and 69 (23.4%) had impaired glucose tolerance. Results: With a cut-off value for the diagnosis of DM of 6.1%, HbA1c had a sensitivity of 81.8% and a specificity of 80%, …


Anti-Diabetic Effects Of An Alcoholic Extract Of Juglans Regia In An Animal Model, Jamshid Mohammadi, Khalil Saadipour, Hamdollah Delaviz, Bahram Mohammadi Jan 2011

Anti-Diabetic Effects Of An Alcoholic Extract Of Juglans Regia In An Animal Model, Jamshid Mohammadi, Khalil Saadipour, Hamdollah Delaviz, Bahram Mohammadi

Turkish Journal of Medical Sciences

Many traditional treatments have been recommended in the alternative system of medicine for treatment of diabetes mellitus. Juglans regia is one of the medicinal plants used in traditional Iranian medicine as a treatment for diabetes, but little scientific documentation supports its antidiabetic action. The purpose of this study was to investigate antidiabetic effect of J. regia leaves in type 1 diabetes induced animal model. Materials and methods: Four groups of animals were selected. Group I animals were fed a normal diet. Animals of groups II, III, and IV received streptozotocin. Animals of groups III and IV were treated with J. …


The Prevalence Of Diabetic Retinopathy In Faisalabad, Pakistan: A Population-Based Study, Fatma Hussain, Mohammad Arif, Munir Ahmad Jan 2011

The Prevalence Of Diabetic Retinopathy In Faisalabad, Pakistan: A Population-Based Study, Fatma Hussain, Mohammad Arif, Munir Ahmad

Turkish Journal of Medical Sciences

To determine the plasma prevalence and characteristics of diabetic retinopathy (DR) among Pakistani diabetic patients in the Faisalabad region. Diabetes mellitus (DM) is a major cause of avoidable blindness worldwide. People with DR are 25 times more likely to become blind than nondiabetics. Materials and methods: The incidence of retinopathy was determined in 1524 people with diabetes during April 2008 and January 2009. Physician-diagnosed diabetic patients underwent an eye examination by ophthalmoscopy and fundus photography. Participants were also interviewed and examined in order to determine demographic characteristics and medical history. Results: Of the 1524 patients screened, 183 (12%) had DR. …


Anti-Diabetic Activity Of Tinospora Cordifolia (Willd.) In Streptozotocin Diabetic Rats; Does It Act Like Sulfonylureas?, Nagaraja Puranik, Kararashah Fakruddin Kammar, Sheela Devi Jan 2010

Anti-Diabetic Activity Of Tinospora Cordifolia (Willd.) In Streptozotocin Diabetic Rats; Does It Act Like Sulfonylureas?, Nagaraja Puranik, Kararashah Fakruddin Kammar, Sheela Devi

Turkish Journal of Medical Sciences

As an alternative medicine to treat diabetes mellitus, many herbal drugs are being studied throughout the world. In the present study, an attempt was made to investigate the anti-diabetic activity of Tinospora cordifolia (Willd.) (TC) stem extracts (both aqueous and alcoholic) in different dosages (200 and 400 mg/kg b.w.) in streptozotocin diabetic albino rats. The probable mechanism by which TC may act as an anti-hyperglycemic drug was also investigated. Materials and methods: The drug was administered orally for 10 days and 30 days in different groups of animal, with each group containing 6 animals. The efficacy of this drug was …


Comparison Of Gliclazide Treatment With Diet Therapy On Acute Phase Protein Levels In Patients With Type 2 Diabetes, Ramazan Memi̇şoğullari, Fati̇h Akçay, Abdurrahman Coşkun, Uğur Korkmaz Jan 2009

Comparison Of Gliclazide Treatment With Diet Therapy On Acute Phase Protein Levels In Patients With Type 2 Diabetes, Ramazan Memi̇şoğullari, Fati̇h Akçay, Abdurrahman Coşkun, Uğur Korkmaz

Turkish Journal of Medical Sciences

Aims: It is known that there is a relationship between diabetic complications and chronic inflammation characterized by alterations in circulating acute phase proteins. It has been emphasized that inflammation contributes to diabetic complications and that gliclazide -an antidiabetic sulfonylurea - decreases the development of such complications. In this study, we aimed to investigate whether gliclazide or diet treatment has an effect on serum levels of acute phase reactants, markers of inflammation. Materials and Methods: Fifty-six newly diagnosed patients with type 2 diabetes and 30 clinically healthy subjects were evaluated prospectively. Twenty-six patients were treated with proper diet and daily gliclazide …