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Full-Text Articles in Medicine and Health Sciences
The Association Of Neuropathic Pain And Disease Activity, Functional Level, And Quality Of Life In Patients With Ankylosing Spondylitis: A Cross-Sectional Study, Duygu Geler Külcü, Sevi̇lay Batibay, Gülcan Öztürk Chatip Chousein Achmet, Ni̇lgün Mesci̇
The Association Of Neuropathic Pain And Disease Activity, Functional Level, And Quality Of Life In Patients With Ankylosing Spondylitis: A Cross-Sectional Study, Duygu Geler Külcü, Sevi̇lay Batibay, Gülcan Öztürk Chatip Chousein Achmet, Ni̇lgün Mesci̇
Turkish Journal of Medical Sciences
Background/aim: Increased neuropathic pain (NP) symptoms are seen in rheumatologic diseases such as bromyalgia, osteoarthritis, and rheumatoid arthritis, but no studies have demonstrated a relationship between ankylosing spondylitis (AS) and NP except for a brain imaging study. e aim of this study was to estimate the presence of NP in patients with AS and to investigate how NP was related to disease activity, functional status, and quality of life. Materials and methods: A total of 100 AS patients (71 males and 29 females; median age: 37 years, range: 18?71 years) were included in the study. Pain (visual analog scale (VAS) …
Changes Of Serum Spd-1 Levels In Hbeag-Positive Chronic Hepatitis B Patients With Entecavir Treatment And Correlation With Curative Effect, Chunhua Bi, Deyu Huang, Jing Jiang, Yueping Jiang, Hui Wang, Cheng Bian, Zibin Tian
Changes Of Serum Spd-1 Levels In Hbeag-Positive Chronic Hepatitis B Patients With Entecavir Treatment And Correlation With Curative Effect, Chunhua Bi, Deyu Huang, Jing Jiang, Yueping Jiang, Hui Wang, Cheng Bian, Zibin Tian
Turkish Journal of Medical Sciences
Background/aim: This study aimed to assess expression changes of serum sPD-1 levels in HBeAg-positive chronic hepatitis B patients with entecavir treatment and explore the correlation with the curative effect. Materials and methods: A total of 220 HBeAg-positive CHB patients and 207 healthy individuals were included. sPD-1 levels and virological and biochemical responses were assessed at baseline and at 12, 24, and 48 weeks in CHB patients a er antiviral therapy. Results: sPD-1 levels in HBeAg-positive CHB patients before treatment were signi cantly lower than those of healthy controls. After entecavir treatment, sPD-1 levels increased gradually over time. At 48 weeks …
Risk Factor Assessment For Breast Cancer In North Cyprus: A Comprehensive Case-Control Study Of Turkish Cypriot Women, Ruqiya Pervaiz, Özgür Tosun, Hasan Besim, Nedi̇me Serakinci
Risk Factor Assessment For Breast Cancer In North Cyprus: A Comprehensive Case-Control Study Of Turkish Cypriot Women, Ruqiya Pervaiz, Özgür Tosun, Hasan Besim, Nedi̇me Serakinci
Turkish Journal of Medical Sciences
Background/aim: This case-control study aims to assess the strength of associations between reproductive, lifestyle, sociodemographic, and dietary factors as well as other potential breast cancer risks and breast cancer (BC) in a North Cyprus population. Materials and methods: The study includes 408 BC patients and 412 age-matched controls recruited from Near East Hospital and Dr. Burhan Nalbantoglu State Hospital in North Cyprus. Information regarding clinical and epidemiological characteristics was collected through a standardized interview. Age-adjusted odds ratios (ORs) and 95% con dence intervals (CIs) were calculated by logistic regression before and a er adjusting for the potential confounders. Results: In …
Association Between Elevated Red Blood Cell Distribution Width And Long-Term Mortality In Acute Pulmonary Embolism, Shahrbanoo Kheirkhah-Sabetghadam, Yaser Jenab, Seyed Mohammad Ghoreyshi- Hefzabad, Keyvan Gohari-Moghadam, Masoumeh Lotfi-Tokaldany, Arash Jalali, Marzieh Pourjafari, Shapour Shirani, Maryam Sotoudeh Anvari, Nasrin Etesamifar
Association Between Elevated Red Blood Cell Distribution Width And Long-Term Mortality In Acute Pulmonary Embolism, Shahrbanoo Kheirkhah-Sabetghadam, Yaser Jenab, Seyed Mohammad Ghoreyshi- Hefzabad, Keyvan Gohari-Moghadam, Masoumeh Lotfi-Tokaldany, Arash Jalali, Marzieh Pourjafari, Shapour Shirani, Maryam Sotoudeh Anvari, Nasrin Etesamifar
Turkish Journal of Medical Sciences
Background/aim: The prognostic value of the red cell distribution width (RDW) as a cost-effective and noninvasive test in acute pulmonary embolism (PE) is still unknown. We aimed to investigate the prognostic value of the admission RDW level in the long-term survival of PE patients. Materials and methods: In this registry-based, prospective cohort study, a total of 378 patients (mean age: 60.4 ± 17.11 years, 47.4% female) who presented with acute PE were enrolled. All the clinical data for each patient were obtained from our institutional PE registry. The follow-up was performed at a median time of 17 months. e primary …
Increased Micronucleus Count Predicts Malignant Behavior In Pleural Effusion Fluid, Tuba Di̇lay Kökenek Ünal, İpek Çoban
Increased Micronucleus Count Predicts Malignant Behavior In Pleural Effusion Fluid, Tuba Di̇lay Kökenek Ünal, İpek Çoban
Turkish Journal of Medical Sciences
Background/aim: Micronucleus (MN) frequency is used as a biomarker of chromosomal damage, genome instability, and cancer risk. e aim of this study was to evaluate the diagnostic usefulness of MN frequency to di erentiate between malignant and benign pleural e usion samples. Materials and methods: Retrospectively, 78 pleural uid cytology samples (including 20 cases of benign reactive mesothelial cells, 22 cases of suspicious cytology, and 36 cases of malignant cytology) were examined. e number of micronucleated cells in 1000 well- preserved cells was counted. Statistical tests were performed to compare the study groups. Recover operating characteristics (ROC) curve analysis was …
Microbiological And Clinical Data Analysis Of 32 Patients With Nocardia Infections In Yantai, Hong-Xia Yu, Ming Liu, Zeng-Hui Pu, Yan Liu, Mao-Mao Zhao
Microbiological And Clinical Data Analysis Of 32 Patients With Nocardia Infections In Yantai, Hong-Xia Yu, Ming Liu, Zeng-Hui Pu, Yan Liu, Mao-Mao Zhao
Turkish Journal of Medical Sciences
Background/aim: Nocardia is an opportunistic pathogen that mostly a ects hosts with immune de ciencies. Recently, the widespread use of immunosuppressive agents and antitumor drugs has led to an increasing number of Nocardia infections being reported. However, it is di cult to con rm this diagnosis owing to the slow growth of the bacterium and its complex resultant clinical manifestations, potentially delaying treatment and increasing mortality. us, further knowledge on the clinical characteristics of Nocardia infection is required. Hence, this study aimed to review the demographics, comorbidities, clinical presentation, microbiology, treatment, and outcomes of Nocardia infections in Yantai. Materials and …
Hand Infection In Patients With Diabetes: A Series Of 17 Cases And A Pooled Analysis Of The Literature, Anil Murat Öztürk, Serhat Uysal, Ilgin Yildirim Şi̇mşi̇r, Hi̇lmi̇ Güngör, Meltem Taşbakan
Hand Infection In Patients With Diabetes: A Series Of 17 Cases And A Pooled Analysis Of The Literature, Anil Murat Öztürk, Serhat Uysal, Ilgin Yildirim Şi̇mşi̇r, Hi̇lmi̇ Güngör, Meltem Taşbakan
Turkish Journal of Medical Sciences
Background/aim: The aim of this study was to report the clinical characteristics and the treatment outcomes of hand infections in diabetic patients and to review the literature. Materials and methods: The medical records of 17 patients with diabetic hand infections admitted to the Diabetic Foot Care Center of two di erent clinics from January 2012 to October 2017 were reviewed. To perform the pooled analysis, published series (32 studies) were searched in two international databases (www.scopus.com and www.pubmed.com). Results: Of the 17 patients (mean age 61.7 ± 8.5 years), 8 (47.1%) were female. All cases were type 2 diabetes mellitus. …
Increased Concentrations Of Serum Nesfatin-1 Levels In Childhood With Idiopathic Chronic Malnutrition, Sezer Acar, Gönül Çatli, Tuncay Küme, Hale Ünver Tuhan, Özlem Gürsoy Çalan, Korcan Demi̇r, Ece Böber, Ayhan Abaci
Increased Concentrations Of Serum Nesfatin-1 Levels In Childhood With Idiopathic Chronic Malnutrition, Sezer Acar, Gönül Çatli, Tuncay Küme, Hale Ünver Tuhan, Özlem Gürsoy Çalan, Korcan Demi̇r, Ece Böber, Ayhan Abaci
Turkish Journal of Medical Sciences
Background/aim: Nesfatin-1, an anorexigenic molecule, seems to play a role in appetite regulation and energy homeostasis. e goal of this study was to evaluate the relation of nesfatin-1 with anthropometric and metabolic (ghrelin, leptin) parameters in children with idiopathic chronic malnutrition. Materials and methods: The study included 37 underweight and 38 healthy children who were similar regarding age, sex, and pubertal status. Anthropometric and biochemical (nesfatin-1, ghrelin, and leptin levels) variables were assessed. Results: A total of 37 underweight subjects (mean age 10.5 ± 2.6 years) and 38 heathy subjects (mean age 10.3 ± 2.3 years) were recruited. Underweight children …
Microdeletion And Mutation Analysis Of The Shox Gene In Patients With Idiopathic Short Stature With Fish And Sequencing, Abdullati̇f Bakir, Meral Yi̇rmi̇beş Karaoğuz, Ferda Emri̇ye Perçi̇n, Esra Tuğ, Peyami̇ Ci̇naz, Mehmet Ali̇ Ergün
Microdeletion And Mutation Analysis Of The Shox Gene In Patients With Idiopathic Short Stature With Fish And Sequencing, Abdullati̇f Bakir, Meral Yi̇rmi̇beş Karaoğuz, Ferda Emri̇ye Perçi̇n, Esra Tuğ, Peyami̇ Ci̇naz, Mehmet Ali̇ Ergün
Turkish Journal of Medical Sciences
Background/aim: The aim of this study was to investigate the prevalence of the microdeletions and mutations of the SHOX gene in children with idiopathic short stature (ISS) by the usage of uorescence in situ hybridization (FISH) and direct sequencing technique. Materials and methods: Thirty-seven children referred to our clinic because of short stature were classi ed as having ISS a er clinical examination. Chromosome analyses, FISH analysis of the SHOX gene, and direct sequencing of the coding exons of SHOX, through the second to the sixth exon, in 24 of the 37 patients were also performed. Results: All children had …
Comparison Of Percutaneous Nephrostomy And Double J Stent In Symptomatic Pregnancy Hydronephrosis Treatment, Adnan Şi̇mşi̇r, Fuat Kizilay, Mehmet Bülent Semerci̇
Comparison Of Percutaneous Nephrostomy And Double J Stent In Symptomatic Pregnancy Hydronephrosis Treatment, Adnan Şi̇mşi̇r, Fuat Kizilay, Mehmet Bülent Semerci̇
Turkish Journal of Medical Sciences
Background/aim: We aimed to compare the success rate of percutaneous nephrostomy (PCN) and double J stenting (DJS) in the treatment of symptomatic pregnancy hydronephrosis. Materials and methods: Diagnosis and grading of hydronephrosis were performed by urinary ultrasound (USG) and Doppler mode was used for evaluation of renal arterial resistivity index (RI). Patients were divided into two groups according to the method used for the treatment of hydronephrosis: group A (PCN, n = 38) and group B (DJS, n = 46). A P value < 0.05 was considered signi cant. Results: The number of patients requiring second intervention was higher in group B (P = 0.0018) and time to secondary intervention was signi cantly earlier in group B also (P = 0.0025). e number of tertiary intervention was again higher in group B (5/16 vs. 1/6) and the need for tertiary intervention was higher in patients who underwent DJS implantation as a secondary intervention than those who underwent PCN (5/11 vs. 1/11, P = 0.0012). e time to tertiary intervention was longer in patients with PCN than in those with DJS (P = 0.0048). Conclusion: PCN may be preferred to DJS in symptomatic pregnancy hydronephrosis because it requires fewer re-interventions a er longer times.
A Survey On Rectal Bleeding In Children, A Report From Iran, Seyed Mohsen Dehghani, Iraj Shahramian, Maryam Ataollahi, Ali Bazi, Nosaibe Seirfar, Mojtaba Delaramnasab, Ali Reza Sargazi, Mahsa Shariat Razavi
A Survey On Rectal Bleeding In Children, A Report From Iran, Seyed Mohsen Dehghani, Iraj Shahramian, Maryam Ataollahi, Ali Bazi, Nosaibe Seirfar, Mojtaba Delaramnasab, Ali Reza Sargazi, Mahsa Shariat Razavi
Turkish Journal of Medical Sciences
Background/aim: Studies on the epidemiology of rectal bleeding in children are limited in Iran. Our aim was to assess etiologies of rectal bleeding in children in Iran. Materials and methods: We enrolled 730 children with rectal bleeding. All the patients underwent colonoscopy, and 457 were further evaluated with histopathology. Results: According to colonoscopy and histopathology, respectively, in ammatory bowel disease (IBD) (29.4%, 15.8%), nodular hyperplasia (NH) (24.9%, 10%), and juvenile polyposis (JP) (12.6%, 9.9%) were the most common causes of rectal bleeding. Other conditions were solitary rectal ulcer (5.3%), chronic colitis (4.6%), allergic colitis (3.3%), focal colitis (1.3%), and infectious …
Insulin-Like Growth Factor-1 Receptor Expression In Pediatric Tumors: A Comparative Immunohistochemical Study, Resul Karakuş, Esra Karakuş, Suna Emi̇r, Ayper Eri̇bol, Derya Özyörük
Insulin-Like Growth Factor-1 Receptor Expression In Pediatric Tumors: A Comparative Immunohistochemical Study, Resul Karakuş, Esra Karakuş, Suna Emi̇r, Ayper Eri̇bol, Derya Özyörük
Turkish Journal of Medical Sciences
Background/aim: Insulin-like growth factor-1 receptor (IGF-1R) is a pivotal receptor tyrosine kinase involved in the cell cycle and malignant tumor transformation. It is di erentially expressed in various types of tumors. We aimed to determine the expression of IGF- 1R in di erent pediatric tumors and to shed light on possible new indications of anti-IGF-1R treatment approaches. Materials and methods: A total of 147 specimens were analyzed according to their expression of IGF-1R. Specimens included those from rhabdomyosarcomas, Wilms tumors, Ewing sarcoma/primitive neuroectodermal tumors, peripheral neuroblastic tumors, acute lymphoblastic lymphoma, Hodgkin lymphoma, Burkitt lymphoma, retinoblastoma, pleuropulmonary blastoma, Langerhans cell histiocytosis, …
The Relation Between Isolated Micropenis In Childhood With Cag And Ggn Repeat Polymorphisms In The Androgen Receptor Gene, Esra Tuğ, Sezen Günteki̇n Ergün, Mehmet Ali̇ Ergün, Fatma Ni̇hal Di̇lek, Ferda Emri̇ye Perçi̇n
The Relation Between Isolated Micropenis In Childhood With Cag And Ggn Repeat Polymorphisms In The Androgen Receptor Gene, Esra Tuğ, Sezen Günteki̇n Ergün, Mehmet Ali̇ Ergün, Fatma Ni̇hal Di̇lek, Ferda Emri̇ye Perçi̇n
Turkish Journal of Medical Sciences
Background/aim: In micropenis cases accompanied by external genital abnormalities such as hypospadias and cryptorchidism, infertility and spermatogenic failures have been reported to correlate with androgen receptor (AR) gene CAG and GGN repeat polymorphisms. While there is one study on isolated micropenis and CAG repeats, no study related to GGN repeats has been reported. We investigated the relation between CAG and GGN repeats in the AR gene with development of penis length in boys with isolated micropenis. Materials and methods: A total of 24 Turkish boys with isolated micropenis (
Effects Of Di Erent Drug Treatments On The Proliferation Of Human Ovarian Carcinoma Cell Line Mdah-2774, Şule Ayla, Ayhan Bi̇li̇r, Ahmet Şenol Ertürkoğlu, Gamze Tanriverdi̇, Burak Cem Soner, Kenan Sofuoğlu, Laura Ghisolfi, Gülperi̇ Öktem
Effects Of Di Erent Drug Treatments On The Proliferation Of Human Ovarian Carcinoma Cell Line Mdah-2774, Şule Ayla, Ayhan Bi̇li̇r, Ahmet Şenol Ertürkoğlu, Gamze Tanriverdi̇, Burak Cem Soner, Kenan Sofuoğlu, Laura Ghisolfi, Gülperi̇ Öktem
Turkish Journal of Medical Sciences
Background/aim: In this study, the e ects of resveratrol as a natural polyphenol compound, gemcitabine as an antimetabolite that has nucleoside structure analogous to deoxycytidine, and para-aminophenol-derived paracetamol were investigated with single and combined applications in monolayers of the MDAH-2774 human ovarian cancer cell line. Materials and methods: Drugs were evaluated in cell culture with respect to cell proliferation, cell cytotoxicity (trypan blue dye exclusion test), synthesis phase of cell cycle, and cell structure in 24, 48, 72, and 96 h. Result: Resveratrol and gemcitabine diminished both cell proliferation and cell cycle synthesis phase indication in monolayer cell cultures (P < 0.05). All combination groups showed similar e ects that were mainly more e ective in respect to single usage of resveratrol and gemcitabine in monolayer cell cultures. Conclusion: The effects of gemcitabine, resveratrol, and paracetamol were investigated in monolayers of the MDAH-2774 human ovarian cancer cell line and a decrease in cell number in cell cycle synthesis phase, prevention of cell proliferation, and destruction of cell structure were observed.
The Effects Of Preadministration Of Local Anesthetic On Pulsed Radiofrequency, Tüli̇n Arici, Mustafa Kurçaloğlu, İdri̇s Şevki̇ Köken, Bora Uzuner, Can Eyi̇gör, Meltem Uyar
The Effects Of Preadministration Of Local Anesthetic On Pulsed Radiofrequency, Tüli̇n Arici, Mustafa Kurçaloğlu, İdri̇s Şevki̇ Köken, Bora Uzuner, Can Eyi̇gör, Meltem Uyar
Turkish Journal of Medical Sciences
Background/aim: Pulsed radiofrequency (PRF) has been reported to be a safe and reliable method for the management of a variety of chronic pain syndromes. It is not known whether the preadministration of local anesthetic increases the size of the electrical field. We revealed the effects of administering local anesthetic on PRF and investigated whether they were related to local anesthetic or fluid effects. Materials and methods: Group 1 (n = 18) received PRF to the suprascapular nerve with 1 mL of bupivacaine, group 2 (n = 20) received PRF with 1 mL of physiological saline solution, and group 3 (n …
The Impact Of Plasma Socs3 Levels And Endometrialleukocytes On Unexplained Infertility, Zehra Sema Özkan, Şükri̇ye Derya Deveci̇, Nusret Akpolat, Nafi̇ye Fulya İlhan, Mehmet Şi̇mşek, Hüseyi̇n Ti̇murkan
The Impact Of Plasma Socs3 Levels And Endometrialleukocytes On Unexplained Infertility, Zehra Sema Özkan, Şükri̇ye Derya Deveci̇, Nusret Akpolat, Nafi̇ye Fulya İlhan, Mehmet Şi̇mşek, Hüseyi̇n Ti̇murkan
Turkish Journal of Medical Sciences
Background/aim: To investigate the possible differences in endometrial leukocyte subtype distribution between women with unexplained infertility and normal fertile women and to determine whether there is a correlation between endometrial leukocyte counts and plasma cytokine levels in unexplained infertility. Materials and methods: This case-control study involved 79 infertile and 40 fertile women. Peripheral venous blood samples and endometrial samples were obtained on day 21 of the menstrual cycle. Plasma interleukin-4 (IL4), IL6, IL10, IL17, IL35, interferongamma (IFN-g), tumor necrosis factor-alpha (TNF-a), transforming growth factor-beta (TGF-b), and suppressor of cytokine signaling-3 (SOCS3) levels were determined by enzyme-linked immunosorbent assay. Endometrial CD8, …
Evaluation Of The Facial Nerve And Internal Auditory Canal Cross-Sectional Areas Onthree-Dimensional Fast Imaging Employing Steady-State Acquisition Magnetic Resonanceimaging In Bell's Palsy, Ebru Ozan Sanhal, Hande Arslan
Evaluation Of The Facial Nerve And Internal Auditory Canal Cross-Sectional Areas Onthree-Dimensional Fast Imaging Employing Steady-State Acquisition Magnetic Resonanceimaging In Bell's Palsy, Ebru Ozan Sanhal, Hande Arslan
Turkish Journal of Medical Sciences
Background/aim: This study aimed to evaluate the facial nerve (FN) and internal auditory canal (IAC) on three-dimensional fast imaging employing steady-state acquisition (3D-FIESTA) magnetic resonance imaging (MRI) to define possible structural differences in cases of Bell's palsy (BP). Materials and methods: Fifty-six patients presenting with BP were included in this study. The measurements of the diameters and the cross-sectional areas (CSAs) of the FNs and IACs obtained on 3D-FIESTA MRI both on the affected and unaffected sides of all patients were compared. Results: A significant difference was found between affected and unaffected sides of the patients in terms of the …
Anxiety And Depression States Of Adolescents With Polycystic Ovary Syndrome, Hamdi̇ Ci̇han Emeksi̇z, Aysun Bi̇deci̇, Burçi̇n Nalbantoğlu, Ayşi̇n Nalbantoğlu, Cem Çeli̇k, Yasemi̇n Yulaf, Mahmut Orhun Çamurdan, Peyami̇ Ci̇naz
Anxiety And Depression States Of Adolescents With Polycystic Ovary Syndrome, Hamdi̇ Ci̇han Emeksi̇z, Aysun Bi̇deci̇, Burçi̇n Nalbantoğlu, Ayşi̇n Nalbantoğlu, Cem Çeli̇k, Yasemi̇n Yulaf, Mahmut Orhun Çamurdan, Peyami̇ Ci̇naz
Turkish Journal of Medical Sciences
Background/aim: Various studies have shown that adult patients with polycystic ovary syndrome (PCOS) have higher levels of anxiety and depression compared to their normal counterparts. However, it is still unclear whether these mood disorders already exist in adolescents affected by PCOS. The aim of the present study is to assess differences in anxiety and depression levels between adolescents with PCOS and age- and body mass index (BMI)-matched controls and to determine the possible factor(s) impacting these psychological parameters in adolescents with PCOS. Materials and methods: The study included 80 adolescents with PCOS and 50 age- and BMI-matched controls. All participants …
Comparison Of Prognostic Systems In Cirrhotic Patients With Hepatic Encephalopathy, Adnan Taş, Mehmet Suat Yalçin, Bünyami̇n Saritaş, Banu Kara
Comparison Of Prognostic Systems In Cirrhotic Patients With Hepatic Encephalopathy, Adnan Taş, Mehmet Suat Yalçin, Bünyami̇n Saritaş, Banu Kara
Turkish Journal of Medical Sciences
Background/aim: There are various scoring systems for evaluating prognosis in patients hospitalized in intensive care units (ICUs) with hepatic encephalopathy. These include the Child-Turcotte-Pugh (CTP) classification, Model for End-stage Liver Disease (MELD), chronic liver failure-sequential organ failure assessment (CLIF-SOFA), and Acute Physiology and Chronic Health Evaluation II (APACHE II). In this study, we aimed to compare the various scoring systems to determine the best system for showing the prognosis of patients with a prior diagnosis of cirrhosis who were hospitalized for hepatic encephalopathy. Materials and methods: Patients with known cirrhosis hospitalized in the internal medicine ICU of the Adana Numune …
Visfatin Levels In Hormonally Inactive Adrenal Adenoma And Their Association Withmetabolic Parameters, Alp Atasoy, Evri̇m Çakir, Süleyman Ahbab, Yasemi̇n Erdoğan Döventaş, Maci̇t Koldaş, Hayri̇ye Esra Ataoğlu, Mustafa Yeni̇gün
Visfatin Levels In Hormonally Inactive Adrenal Adenoma And Their Association Withmetabolic Parameters, Alp Atasoy, Evri̇m Çakir, Süleyman Ahbab, Yasemi̇n Erdoğan Döventaş, Maci̇t Koldaş, Hayri̇ye Esra Ataoğlu, Mustafa Yeni̇gün
Turkish Journal of Medical Sciences
Background/aim: In parallel with increased frequency and higher quality of imaging techniques, the prevalence of adrenal adenoma has gradually increased. However, despite the growing incidence, the metabolic and tumorigenesis processes involved in its etiology are still unclear. Although visfatin has been reported to be associated with inflammation and tumorigenesis, its role in adrenal adenoma has not yet been investigated. Therefore, the present study was performed with an aim to evaluate visfatin levels and cardiometabolic risk factors in patients with adrenal adenoma. Materials and methods: Thirty patients recently diagnosed with adrenal adenoma along with 30 healthy participants were studied in a …
Evaluation Of Mesenteric Panniculitis With Computed Tomography: Benign Condition Orparaneoplastic Syndrome?, Ali̇ Küpeli̇, Ayşegül Cansu, Şükrü Oğuz, Süleyman Beki̇rçavuşoğlu, Süha Turkmen, Ali̇ Ahmetoğlu, Gürkan Danişan
Evaluation Of Mesenteric Panniculitis With Computed Tomography: Benign Condition Orparaneoplastic Syndrome?, Ali̇ Küpeli̇, Ayşegül Cansu, Şükrü Oğuz, Süleyman Beki̇rçavuşoğlu, Süha Turkmen, Ali̇ Ahmetoğlu, Gürkan Danişan
Turkish Journal of Medical Sciences
Background/aim: This study aimed to investigate the prevalence and association of mesenteric panniculitis (MP) with other diseases and the clinicoradiological features of MP, and to examine computed tomography findings to estimate the presence of malignancy in patients with MP. Materials and methods: Between September 2012 and August 2016, we used a keyword search to identify patients diagnosed with MP. Associated diseases and malignancies of patients were recorded. Cut-off values and diagnostic efficiencies of total MP scores and short and long diameters of the greatest lymph nodes were determined. Results: Out of 22,033 patients, 309 were determined to have MP (prevalence …
Serum Vasohibin-1 And Suppression Of Tumorigenicity-2 Levels In Children Withpredialysis Chronic Kidney Disease, Nuran Çeti̇n, Nadi̇de Meli̇ke Sav
Serum Vasohibin-1 And Suppression Of Tumorigenicity-2 Levels In Children Withpredialysis Chronic Kidney Disease, Nuran Çeti̇n, Nadi̇de Meli̇ke Sav
Turkish Journal of Medical Sciences
Background/aim: Chronic kidney disease (CKD), which is one of the most important health problems worldwide, could be considered as an immune inflammatory disease. A prognostic biomarker may be helpful in determining the progression of CKD in children. We aimed to investigate the serum vasohibin-1 and soluble suppression of tumorigenicity-2 (sST2) levels as potential biomarkers in children with predialysis CKD. Materials and methods: Forty-seven children with stage 2-4 CKD and 20 healthy controls were included in this cross-sectional study. Glomerular filtration rate (GFR) and urinary excretion of protein were measured in 24-h urine samples. Serum vasohibin-1 levels and sST2 were measured. …
Early Postoperative Follow-Up After Craniosynostosis Surgery, Ebru Ati̇ke Ongun, Oğuz Dursun, Mehmet Sai̇m Kazan, Banu Nur, Ercan Mihçi
Early Postoperative Follow-Up After Craniosynostosis Surgery, Ebru Ati̇ke Ongun, Oğuz Dursun, Mehmet Sai̇m Kazan, Banu Nur, Ercan Mihçi
Turkish Journal of Medical Sciences
Background/aim: Declined morbidity rates after craniosynostosis surgery indicate bypassing the pediatric intensive care unit (PICU) course to minimize treatment costs and bed usage. The aim of this study is to examine the incident rates of PICU admission and assess its necessity. Materials and methods: A retrospective analysis of 41 patients (operated on by open surgical techniques) between July 2011 and December 2015 was carried out. Intraoperative/postoperative vital signs, hemodynamic and metabolic parameters, estimated blood loss (EBVloss), blood transfusions, length of PICU, and hospitalizations were recorded. Results: Major and minor events reached 51.2% and 82.9%, respectively. EBVloss within 24 h was …
Ankaferd Blood Stopper With Antibiofilm Potential Successfully Inhibits The Extracellularmatrix Degradation Enzymes And Promotes Wound Healing Of 3t3 Fibroblasts In Vitro, Ruki̇ye Boran, Tuba Baygar, Nurdan Saraç, Aysel Uğur
Ankaferd Blood Stopper With Antibiofilm Potential Successfully Inhibits The Extracellularmatrix Degradation Enzymes And Promotes Wound Healing Of 3t3 Fibroblasts In Vitro, Ruki̇ye Boran, Tuba Baygar, Nurdan Saraç, Aysel Uğur
Turkish Journal of Medical Sciences
Background/aim: The potential inhibitory effects of Ankaferd Blood Stopper (ABS) against biofilm formation of oral microorganisms and its capacity for collagenase, hyaluronidase, and elastase inhibitions that have important roles in wound healing have been investigated. Materials and methods: The wound healing potential was determined by its inhibition ability on collagenase, hyaluronidase, and elastase enzyme activities and was evaluated via scratch wound healing assay on murine 3T3 fibroblasts. The antibiofilm activity was tested against eight oral microorganisms using the crystal violet staining method. Results: At 10% ABS successfully inhibited the biofilm formation of the tested microorganisms. Enzyme inhibition analysis revealed that …
Tuberculin Skin Test Response In Patients With Juvenile Idiopathic Arthritis Onanti-Tnf Therapy, Kenan Barut, Sezgi̇n Şahi̇n, Amra Adrovi̇c, Muhammet Köşker, Ömer Kiliç, Yildiz Camcioğlu, Haluk Cezmi̇ Çokuğraş, Necla Akçakaya, Betül Sözeri̇, Özgür Kasapçopur
Tuberculin Skin Test Response In Patients With Juvenile Idiopathic Arthritis Onanti-Tnf Therapy, Kenan Barut, Sezgi̇n Şahi̇n, Amra Adrovi̇c, Muhammet Köşker, Ömer Kiliç, Yildiz Camcioğlu, Haluk Cezmi̇ Çokuğraş, Necla Akçakaya, Betül Sözeri̇, Özgür Kasapçopur
Turkish Journal of Medical Sciences
Background/aim: The aim of this study is to evaluate the effect of biologic drugs on the tuberculin skin test in patients with juvenile idiopathic arthritis. Materials and methods: A total of 234 biologic drug-using juvenile idiopathic arthritis patients and 45 healthy controls were enrolled in the study. The tuberculin skin test results of the patients, which had been routinely provided during follow-up, were obtained from the patient files. Tuberculin skin test values of ≥ 5 mm were considered to be positive. Results: The mean diameter of tuberculin skin test induration was 4.99 ± 6.84 mm (IQR: 0-10 mm) and 7.83 …
Diagnostic Value Of Ultrasonography In Peroneal Neuropathy, İlkay Koray Bayrak, Ayşe Oytun Bayrak, Hande Türker, Çeti̇n Kürşad Akpinar, Necdet Bolat
Diagnostic Value Of Ultrasonography In Peroneal Neuropathy, İlkay Koray Bayrak, Ayşe Oytun Bayrak, Hande Türker, Çeti̇n Kürşad Akpinar, Necdet Bolat
Turkish Journal of Medical Sciences
Background/aim: Peroneal neuropathy at the fibular head (PNFH) is one of the most common entrapment neuropathies. Our aim in this study was to analyze the efficiency of ultrasonography in the diagnosis of PNFH. Materials and methods: The study included 15 peroneal nerves of 12 patients with PNFH and 24 peroneal nerves of 12 healthy controls. PNFH confirmation was based on clinical and electrophysiological findings. All patients and controls underwent ultrasonographic evaluations for peroneal nerves. The cross-sectional area (CSA) was measured. Echogenicity of the nerve was evaluated by comparing it with the adjacent connective tissue deep under the subcutaneous fat. Results: …
Pulmonary Valve Replacement In Patients With Repaired Tetralogy Of Fallot: Early Results For Recovery Of Right Ventricular Dilatation And Qrs Duration, Ahmet Arnaz, Ayla Oktay, Serdar Akansel, Di̇lek Altun, Abdullah Doğan, Piotr Serban, Arda Saygili, Yusuf Kenan Yalçinbaş, Ayşe Sarioğlu, Cafer Tayyar Sarioğlu
Pulmonary Valve Replacement In Patients With Repaired Tetralogy Of Fallot: Early Results For Recovery Of Right Ventricular Dilatation And Qrs Duration, Ahmet Arnaz, Ayla Oktay, Serdar Akansel, Di̇lek Altun, Abdullah Doğan, Piotr Serban, Arda Saygili, Yusuf Kenan Yalçinbaş, Ayşe Sarioğlu, Cafer Tayyar Sarioğlu
Turkish Journal of Medical Sciences
Background/aim: Although pulmonary valve replacement (PVR) improves ventricular function and symptoms, the benefit and optimal timing of PVR are controversial. This study aimed to evaluate early response to PVR for right ventricle (RV) dilatation and QRS duration. Materials and methods: Retrospective analysis was performed for 32 patients with repaired tetralogy of Fallot (TOF) between March 2005 and October 2017. The differences between preoperative and postoperative changes in echocardiographic parameters, clinical symptoms, and QRS duration were evaluated. Results: There were no in-hospital or late deaths. Mean age at the time of PVR was 16.57 ± 7.97 years. The interval between TOF …
Is 72 H Of Antimicrobial Prophylaxis Better Than 24 H In Elective Gastric Cancer Surgery?, Xiang Zia, Gang Zhao, Wei Ling, Fengrong Yu
Is 72 H Of Antimicrobial Prophylaxis Better Than 24 H In Elective Gastric Cancer Surgery?, Xiang Zia, Gang Zhao, Wei Ling, Fengrong Yu
Turkish Journal of Medical Sciences
Background/aim: The optimum duration of antimicrobial prophylaxis in elective gastric cancer surgery is still not yet established. The aim of this study is to evaluate the efficacy of 24 h or 72 h of antimicrobial prophylaxis for preventing postoperative infection. Materials and methods: Between July 2016 and January 2018, 990 gastric cancer patients undergoing surgery with D2 lymphadenectomy in Ren Ji Hospital were classified into 24-h or 72-h antimicrobial prophylaxis groups. The incidence of postoperative infection complications was compared. Results: A total of 990 patients (24-h antimicrobial prophylaxis, 708 cases; 72-h antimicrobial prophylaxis, 282 cases) were analyzed. Surgical site infection …
The Diagnostic Role Of Pentraxin-3 In The Differential Diagnosis Of Pleural Effusions, Fatma Çi̇ftci̇, Gülden Bi̇lgi̇n, Ayşe Naz Özcan, Özlem Doğan, Aycan Yüksel, Serhat Erol, Aydin Çi̇ledağ, Akin Kaya
The Diagnostic Role Of Pentraxin-3 In The Differential Diagnosis Of Pleural Effusions, Fatma Çi̇ftci̇, Gülden Bi̇lgi̇n, Ayşe Naz Özcan, Özlem Doğan, Aycan Yüksel, Serhat Erol, Aydin Çi̇ledağ, Akin Kaya
Turkish Journal of Medical Sciences
Background/aim: Discrimination of pleural effusion etiology is not always easy in clinical practice. Pentraxin-3 (PTX-3) is a new acute- phase protein. The aim of this study was to investigate the role of PTX-3 in the differential diagnosis of pleural effusions. Materials and methods: This prospective study enrolled all consecutive patients from two tertiary hospitals who underwent diagnostic or therapeutic thoracentesis. In a cohort of 149 subjects with pleural effusion, including transudates and malignant (MPE), tuberculous (TPE), and parapneumonic effusion (PPE), serum and pleural effusion PTX-3 concentration measurements were performed using ELISA. Serum and pleural effusion protein, lactate dehydrogenase, C-reactive protein …
The Role Of Soluble Urokinase Plasminogen Activator Receptor (Supar) As An Indicator Of The Severity Of Acute Pancreatitis, Kadi̇r Küçükceran, Mehmet Ergi̇n, İbrahi̇m Kilinç, Adnan Karai̇brahi̇moğlu, Tamer Çolak, Alpay Tuncar, Zerri̇n Defne Dündar, Sedat Koçak, Abdullah Sadik Gi̇ri̇şgi̇n, Mehmet Gül, Başar Cander
The Role Of Soluble Urokinase Plasminogen Activator Receptor (Supar) As An Indicator Of The Severity Of Acute Pancreatitis, Kadi̇r Küçükceran, Mehmet Ergi̇n, İbrahi̇m Kilinç, Adnan Karai̇brahi̇moğlu, Tamer Çolak, Alpay Tuncar, Zerri̇n Defne Dündar, Sedat Koçak, Abdullah Sadik Gi̇ri̇şgi̇n, Mehmet Gül, Başar Cander
Turkish Journal of Medical Sciences
Background/aim: Soluble urokinase plasminogen activator receptor (suPAR) has been reported to have a positive correlation with the activation degree of the immune system. This study's aim is to investigate the efficiency of SuPAR serum levels in acute pancreatitis (AP) patients in determining the severity of disease. Materials and methods: This prospective research involves patients who arrived at the emergency service, were over 18 years old, had nontraumatic abdominal pain and diagnosis of AP, and agreed to join the study. Demographic characteristics, contact information, laboratory and imaging test parameters, Ranson's criteria, the Balthazar Severity Index, the Rapid Acute Physiologic Score (RAPS), …