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Full-Text Articles in Medicine and Health Sciences

Investigating Toxic Effects Of The Hiv-Rt Inhibitor 2-Phenoxymethyl-5-Chloro-Benzimidazole On Rat Liver, Yeşi̇m Uğur, Ayşegül Akbay Yarpuzlu, Ayşegül Nazi̇koğlu, Esi̇n Aşan, İlkay Yildiz, Şükrü Keleş Jan 2005

Investigating Toxic Effects Of The Hiv-Rt Inhibitor 2-Phenoxymethyl-5-Chloro-Benzimidazole On Rat Liver, Yeşi̇m Uğur, Ayşegül Akbay Yarpuzlu, Ayşegül Nazi̇koğlu, Esi̇n Aşan, İlkay Yildiz, Şükrü Keleş

Turkish Journal of Medical Sciences

The aim of this study was to investigate the toxic effects of the human immunodeficiency virus- reverse transcriptase (HIV-RT) inhibitor 2-phenoxymethyl-5-chlorobenzimidazole on rat liver at the light microscopic level to gain an insight into possible effects in human subjects. To do this, an animal experimental model was constructed and rats were divided into single injected rat (SIR) and multiple injected rat (MIR) groups, as well as single and multiple solvent dimethylsulfoxide (DMSO) injected controls and an untreated control. Cellular heterogeneity was observed in a non-prominent way in the SIR group (prominent in only one area) and very prominently in the …


Multidisciplinary Treatment Approach For The Localized Gingival Recession: A Case Report, Işil Saygun, Şeni̇z Karaçay, Ati̇lla Özdemi̇r, Deni̇z Sağdiç Jan 2005

Multidisciplinary Treatment Approach For The Localized Gingival Recession: A Case Report, Işil Saygun, Şeni̇z Karaçay, Ati̇lla Özdemi̇r, Deni̇z Sağdiç

Turkish Journal of Medical Sciences

GUN^1, Şeniz KARAÇAY^2, Atilla ÖZDEMİR^1, Deniz SAĞDIÇ^2 ^1Department of Periodontology, Gülhane Military Medical Academy, Ankara - Turkey ^2Department of Orthodontics, Gülhane Military Medical Academy, Ankara - Turkey


A New Diagnostic System In Cancer Research: Bioluminescent Imaging (Bli), Z. Günnur Di̇kmen, Ginelle Gellert, Paki̇ze Doğan, Ralph Mason, Peter Antich, Edmond Richer, Woodring E. Wright, Jerry W. Shay Jan 2005

A New Diagnostic System In Cancer Research: Bioluminescent Imaging (Bli), Z. Günnur Di̇kmen, Ginelle Gellert, Paki̇ze Doğan, Ralph Mason, Peter Antich, Edmond Richer, Woodring E. Wright, Jerry W. Shay

Turkish Journal of Medical Sciences

Bioluminescent imaging (BLI) is particularly well suited for imaging small animals, and it can be readily used by scientists who are already routinely using the luciferase gene as a reporter in cell-based assays. This strategy relies on ATP and an O_2 dependent photochemical reaction between luciferin and luciferase, resulting in the release of photons from only live cells. In BLI, the intensity of the light detected by the device is proportional to the intensity of light emitted and the relationship is quantitative. This study was performed to determine the sensitivity of BLI for the imaging of lung metastasis and breast …


The Quality Of Collaboration Among Medical Research Centers, Universities, Health Executives And The Community In İran, Saeed Asefzadeh Jan 2005

The Quality Of Collaboration Among Medical Research Centers, Universities, Health Executives And The Community In İran, Saeed Asefzadeh

Turkish Journal of Medical Sciences

A health research system is defined as a system for planning, coordinating, monitoring and managing health research resources and activities, and for promoting research aimed at effective and equitable national health development. This study was conducted to describe the quality of mutual collaboration among medical research centers, universities, executive organizations and the community. In this situation analysis qualitative methods were applied. In-depth interviews were held with the heads of 20 research centers (RCs), 6 senior executive health administrators at national level, 10 vice chancellors at universities and 3 directors of private medical research firms. In addition to the interviews, records …


Transient Silent Ischemia After Ptca Manifested With A Bizarre Ecg, Hakan Özhan, Ramazan Akdemi̇r, Sadik Duran, Mehmet Yazici, Hüseyi̇n Arinç, Hüseyi̇n Gündüz, Ci̇hangi̇r Uyan Jan 2005

Transient Silent Ischemia After Ptca Manifested With A Bizarre Ecg, Hakan Özhan, Ramazan Akdemi̇r, Sadik Duran, Mehmet Yazici, Hüseyi̇n Arinç, Hüseyi̇n Gündüz, Ci̇hangi̇r Uyan

Turkish Journal of Medical Sciences

HAN^1, Ramazan AKDEMİR^1, Sadık DURAN^1, Mehmet YAZICI^1, Hüseyin ARINÇ^2, Hüseyin GÜNDÜZ^2, Cihangir UYAN^2 ^1Department of Cardiology, Düzce Faculty of Medicine, Abant İzzet Baysal University, Düzce - Turkey ^2Department of Cardiology, İzzet Baysal Faculty of Medicine, Abant İzzet Baysal University, Bolu - Turkey


Fatal Liver Failure Secondary To Chemotherapy Induced Hepatitis-B Virus Reactivation In A Patient With Acute Myeloid Leukemia, Zülal Özkurt, Mustafa Ertek, Ayten Kadanali, Serpi̇l Erol, Mehmet Parlak Jan 2005

Fatal Liver Failure Secondary To Chemotherapy Induced Hepatitis-B Virus Reactivation In A Patient With Acute Myeloid Leukemia, Zülal Özkurt, Mustafa Ertek, Ayten Kadanali, Serpi̇l Erol, Mehmet Parlak

Turkish Journal of Medical Sciences

KURT, Mustafa ERTEK, Ayten KADANALI, Serpil EROL, Mehmet PARLAK Department of Clinical Bacteriology and Infectious Diseases, Faculty of Medicine, Atatürk University, Erzurum - Turkey


Heterotopic Bone Formation In Upper Midline Abdominal Incision, Bumi̇n Deği̇rmenci̇, Murat Acar, Ramazan Albayrak, Alpay Haktanir, Ayli̇n Yücel, Osman Nuri̇ Di̇lek Jan 2005

Heterotopic Bone Formation In Upper Midline Abdominal Incision, Bumi̇n Deği̇rmenci̇, Murat Acar, Ramazan Albayrak, Alpay Haktanir, Ayli̇n Yücel, Osman Nuri̇ Di̇lek

Turkish Journal of Medical Sciences

ĞİRMENCİ^1, Murat ACAR^1, Ramazan ALBAYRAK^1, Alpay HAKTANIR^1, Aylin YÜCEL^1, Osman Nuri DİLEK^2 ^1Department of Radiology, Faculty of Medicine, Kocatepe University, Afyon - Turkey ^2Department of General Surgery, Faculty of Medicine, Kocatepe University, Afyon - Turkey


Wolfram Syndrome (Ws), Neither An Autosomal Nor A Sex Linked Disorder, Şi̇nasi̇ Özsoylu Jan 2005

Wolfram Syndrome (Ws), Neither An Autosomal Nor A Sex Linked Disorder, Şi̇nasi̇ Özsoylu

Turkish Journal of Medical Sciences

No abstract provided.


Importance Of Calcium, Beri̇van Tandoğan, N. Nuray Ulusu Jan 2005

Importance Of Calcium, Beri̇van Tandoğan, N. Nuray Ulusu

Turkish Journal of Medical Sciences

Calcium is the most abundant mineral in the body. Calcium regulates many cellular processes and has important structural roles in living organisms. Skeletal muscle structure and function, polymerisation of fibrin and the conduction of impulses in the nervous system are regulated by calcium. Calcium is an important intracellular messenger in protozoa, plants, and animals. Calcium-transporting systems which are located in the plasma membrane and in the organelles, regulate the ionic concentration of calcium in various compartments according to the different demands of the physiological cycle and these systems upregulate calcium entry by the action of several hormones and calcium binding …


An Overview Of Keratinocyte Carcinoma And Prospective Study On The Accuracy Of The Surgeon’S Diagnosis Of Keratinocyte Carcinoma, Nesri̇n Tan Başer, Nurten Yavuz, Ahmet Terzi̇oğlu, Gürcan Aslan Jan 2005

An Overview Of Keratinocyte Carcinoma And Prospective Study On The Accuracy Of The Surgeon’S Diagnosis Of Keratinocyte Carcinoma, Nesri̇n Tan Başer, Nurten Yavuz, Ahmet Terzi̇oğlu, Gürcan Aslan

Turkish Journal of Medical Sciences

This article concerning the rate of accurate diagnosis of keratinocyte carcinoma is reported by experienced surgeons. Keratinocyte carcinoma (KC) has been recently used in order to define basal cell carcinoma and squamous cell carcinoma. Although an histopathologic analysis is standard for diagnosis, clinical diagnosis is still important for the choice of proper treatment. In this prospective study, 204 lesions were excised following clinical pre-diagnosis of keratinocyte carcinoma. The lesions were excised from the proper surgical limit for clinical diagnosis and sent for histopathologic examination. We have seen that we frequently confuse BCC s and SCC s with actinic keratosis. According …


Prenatal Diagnosis Of B-Thalassemia In The Antalya Province, İbrahi̇m Keser, Esra Manguoğlu, Özlem Güzeloğlu Kayişli, Fatma Kurt, İnanç Mendi̇lci̇oğlu, Mehmet Şi̇mşek, Gülseren Bağci, Güven Lüleci̇ Jan 2005

Prenatal Diagnosis Of B-Thalassemia In The Antalya Province, İbrahi̇m Keser, Esra Manguoğlu, Özlem Güzeloğlu Kayişli, Fatma Kurt, İnanç Mendi̇lci̇oğlu, Mehmet Şi̇mşek, Gülseren Bağci, Güven Lüleci̇

Turkish Journal of Medical Sciences

Beta-thalassemia and Sickle cell anemia are serious health problems in the Antalya Province of Turkey as well as World Wide. We aimed to summarize data obtained from the prenatal diagnosis for beta-thalassemia and sickle cell anemia of 103 fetuses. All samples were cytogenetically and molecular genetically examined during a period of 4 years. Molecular testing using RDBH and direct DNA sequencing was performed by using amplified DNA from chorionic villi samples at 9-14 weeks of gestation, while mutations in the parents were determined in advance. Cytogenetic analysis was carried out from a primary culture set up. Of the 103 fetuses, …


Giant Juxtadrenal And Adrenal Schwannoma With Concurrent Adrenal Myelolipoma Mimicking An Adrenal Malignant Tumor, Gaye Güler Tezel, Nazmi̇ye Karaman, Derya Karakoç, Kaya Yorganci Jan 2005

Giant Juxtadrenal And Adrenal Schwannoma With Concurrent Adrenal Myelolipoma Mimicking An Adrenal Malignant Tumor, Gaye Güler Tezel, Nazmi̇ye Karaman, Derya Karakoç, Kaya Yorganci

Turkish Journal of Medical Sciences

ER TEZEL^1, Nazmiye KARAMAN^1, Derya KARAKOÇ^2, Kaya YORGANCI^2 ^1Department of Pathology, Faculty of Medicine, Hacettepe University, Ankara - Turkey ^2Department of General Surgery, Faculty of Medicine, Hacettepe University, Ankara - Turkey


Correlation Between Down Syndrome And The Level Of Placental Alkaline Phosphatase In Amniotic Fluid, Canan Uçar, Sevi̇m Balci, Ergül Tunçbi̇lek, İbrahi̇m Ünsal Jan 2005

Correlation Between Down Syndrome And The Level Of Placental Alkaline Phosphatase In Amniotic Fluid, Canan Uçar, Sevi̇m Balci, Ergül Tunçbi̇lek, İbrahi̇m Ünsal

Turkish Journal of Medical Sciences

The aim of this study was to investigate the correlation between Down syndrome and the level of placental alkaline phosphatase (PLAP) in amniotic fluid. A total of 279 amniotic fluid samples taken between 14 and 24 gestational weeks were investigated in this study. Karyotype analysis was made in all samples. In 10 samples trisomy 21 was determined, in one sample trisomy 18, in two samples 47,XXY, in six samples various structural chromosomal anomalies and in 260 samples normal karyotype. PLAP was measured using a fluorometric heat inactivation assay. Mean PLAP multiples of normal gestational median (MOM) value in samples with …


Salivary Malondialdehyde Levels In Patients With Oral Leukoplakia, Yegane Güven, Meral Ünür, Kivanç Bektaş, Ezel Uslu, Ahmet Belce, Erdi̇nç Demi̇rez, Şule Can Jan 2005

Salivary Malondialdehyde Levels In Patients With Oral Leukoplakia, Yegane Güven, Meral Ünür, Kivanç Bektaş, Ezel Uslu, Ahmet Belce, Erdi̇nç Demi̇rez, Şule Can

Turkish Journal of Medical Sciences

Since leukoplakia is a premalignant condition, it is evident that an effective means of control would contribute to reducing the mortality and morbidity of oral cancer. The reactivity of free radicals and singlet oxygen is believed to be an important factor in the pathogenesis of many degenerative diseases including carcinogenesis. Reactive free radicals may damage cells by induction of lipid peroxidation of the polyunsaturated fatty acids. Buege and Aust's method was used for lipid peroxidation analysis. One way of estimating free radical activity and lipid peroxidation is to determine the concentration of malondialdehyde (MDA) in the body fluids. MDA concentration …


Effect Of Carotid Stenosis On The Development Of Subarachnoid Hemorrhage: An Experimental Study, Canan Atalay, Ednan Bayram, Mehmet Dumlu Aydin, Mehmet Bi̇li̇ci̇, Zafer Okumuş, Cemal Gündoğdu Jan 2005

Effect Of Carotid Stenosis On The Development Of Subarachnoid Hemorrhage: An Experimental Study, Canan Atalay, Ednan Bayram, Mehmet Dumlu Aydin, Mehmet Bi̇li̇ci̇, Zafer Okumuş, Cemal Gündoğdu

Turkish Journal of Medical Sciences

Subarachnoid hemorrhage (SAH) may be seen after the invasive procedures of occlusive carotid artery disease. The objective of this experimental study is to investigate the effect of bilateral common carotid artery ligation (BCCAL) on the development of subarachnoid hemorrhage (SAH).Twenty Wistar adult rats (150-200g) were randomly divided into two groups, as follows: (ı) Control group (without BCCAL, n = 5), (II) BCCAL group (n = 15). All rats were sacrificed three months later. The basilar artery with surrounding tissue was removed from the cranium and processed for paraffin embedding. Histopathological and Stereological examinations of the basilar artery were made. During …


Sjögren's Syndrome: A Study Of Salivary Electrophoresis, Mehmet Yaltirik, Hülya Koçak Berberoğlu, Kivanç Ergen, Bariş Aydil Jan 2005

Sjögren's Syndrome: A Study Of Salivary Electrophoresis, Mehmet Yaltirik, Hülya Koçak Berberoğlu, Kivanç Ergen, Bariş Aydil

Turkish Journal of Medical Sciences

Many diagnostic tests exist to assess the salivary and lacrimal involvement in Sjögren's syndrome (SS), but there is still disagreement. The purpose of this study was to examine salivary proteins in patients with primary Sjögren's syndrome and healthy control subjects by the polyacrylamide gel electrophoresis, as well as the applicability of the method. The polyacrylamide gel electrophoresis, applied in our examinations, is a simple and rapid method, requiring only a minute amount of saliva for the analysis. Saliva were collected from patients suffering from primary Sjögren's syndrome (n = 10) and a control group (n = 10). All saliva samples …


Ebola: A Significant Threat As An Infectious Disease, And As A Potential Bioterrorism Agent, Çağatay Üstün, Özge Özgürler Jan 2005

Ebola: A Significant Threat As An Infectious Disease, And As A Potential Bioterrorism Agent, Çağatay Üstün, Özge Özgürler

Turkish Journal of Medical Sciences

No abstract provided.


Acute Stress Ameliorates Colitis Via Central Corticotropin- Releasing Factor And Serotonin (5-Ht)-3 Receptors, Mehmet Ali̇ Gülpinar, Di̇lek Özbeyli̇, Serap Arbak, Berrak C. Yeğen Jan 2005

Acute Stress Ameliorates Colitis Via Central Corticotropin- Releasing Factor And Serotonin (5-Ht)-3 Receptors, Mehmet Ali̇ Gülpinar, Di̇lek Özbeyli̇, Serap Arbak, Berrak C. Yeğen

Turkish Journal of Medical Sciences

The central nervous system may modulate many aspects of inflammation through alterations of the autonomic nervous system and/or the hypothalamo-pituitary-adrenal (HPA) axis. The aim of present study was to examine the impact of controllable acute stress on the course of experimental colitis and to elucidate the roles of serotonin (5-HT) and corticotropin-releasing factor (CRF) in the central modulation of the stress. In the stress group, acute electric shock (AES; 0.3-0.6 mA) was applied, while in the central agonist group, rats were injected with central 5-HT agonist (400 µg/kg). In the antagonist groups, 10 min before the application of AES or …


Estimation Of Sensitivity And Specificity For Clustered Data, Yasemi̇n Genç, Derya Gökmen, Ersöz Tüccar, Banu Yağmurlu Jan 2005

Estimation Of Sensitivity And Specificity For Clustered Data, Yasemi̇n Genç, Derya Gökmen, Ersöz Tüccar, Banu Yağmurlu

Turkish Journal of Medical Sciences

The most commonly used measurements for evaluating the accuracy of diagnostic tests in binary data are sensitivity and specificity. Sensitivity refers to the ability of a test to detect patients with some specific disease. Specificity describes how well test abnormality is restricted to those persons who have the disease in question. The variance estimators of these measurements are usually obtained using a binomial estimator, although there are several other methods. However, under certain conditions more than one observation can be taken from a subject and analyses are performed on these observations. This type of data structure is called "clustered data". …


The Level Of Ferritin In Diabetic And Nondiabetic Patients With Acute Myocardial Infarction, Meral Mert, Müge Korkmaz, Mustafa Temi̇zel, Meti̇n Acar Jan 2005

The Level Of Ferritin In Diabetic And Nondiabetic Patients With Acute Myocardial Infarction, Meral Mert, Müge Korkmaz, Mustafa Temi̇zel, Meti̇n Acar

Turkish Journal of Medical Sciences

An elevated serum ferritin level is proposed as a risk factor for coronary heart disease. The role of diabetes mellitus on serum ferritin levels in myocardial infarction has recently been investigated. The purpose of this study was to assess the effects of diabetes mellitus on serum ferritin levels in patients with acute myocardial infarction (AMI). In this study, we studied patients (104 nondiabetic, 26 diabetic patients) with acute myocardial infarction (AMI). AMI was diagnosed according to typical clinical history, ECG changes and cardiac enzyme elevations. Blood samples for ferritin, iron and total iron binding capacity (TIBC) and haemogram tests were …


Knowledge About Breast Cancer And Mammography In Breast Cancer Screening Among Women Awaiting Mammography, Ayli̇n Yücel, Bumi̇n Deği̇rmenci̇, Murat Acar, Hülya Elli̇dokuz, Ramazan Albayrak, Alpay Haktanir Jan 2005

Knowledge About Breast Cancer And Mammography In Breast Cancer Screening Among Women Awaiting Mammography, Ayli̇n Yücel, Bumi̇n Deği̇rmenci̇, Murat Acar, Hülya Elli̇dokuz, Ramazan Albayrak, Alpay Haktanir

Turkish Journal of Medical Sciences

The purpose of this study was to evaluate knowledge about breast cancer and mammography in breast cancer screening among women awaiting mammographic examination. A cross-sectional survey was carried out of 298 women with an age range of 29-79 years through interview before mammographic examination. The questionnaire was designed specifically for this study, and a total of 100 points was given for all correct answers. Women's perception of susceptibility to breast cancer, severity of the disease, barriers to breast cancer screening, and perceived benefits of mammography were determined. Their knowledge about the risk factors of breast cancer and self-examination were also …


Multiple Aneurysms Of The Left External Jugular Vein, Sami̇ Karapolat, Bi̇lgehan Erkut, Yahya Ünlü Jan 2005

Multiple Aneurysms Of The Left External Jugular Vein, Sami̇ Karapolat, Bi̇lgehan Erkut, Yahya Ünlü

Turkish Journal of Medical Sciences

APOLAT, Bilgehan ERKUT, Yahya ÜNLÜ Department of Cardiovascular Surgery, Faculty of Medicine, Atatürk University, Erzurum - Turkey


Additional Distinct Findings In Three Cases With Wolfram Syndrome, Ni̇met Kabakuş, A. Neşe Çitak Kurt, Abdullah Kurt, Hani̇fi̇ Yildirim, Turgut Yilmaz, Saadet Akarsu Jan 2005

Additional Distinct Findings In Three Cases With Wolfram Syndrome, Ni̇met Kabakuş, A. Neşe Çitak Kurt, Abdullah Kurt, Hani̇fi̇ Yildirim, Turgut Yilmaz, Saadet Akarsu

Turkish Journal of Medical Sciences

No abstract provided.


Differential Effect Of Glutathione Depletion On Glycogenolysis In Isolated Rat Hepatocytes Mediated By A-Adrenoceptor Agonists And Glucagon, Mukadder Atmaca, Jeffrey R. Fry Jan 2005

Differential Effect Of Glutathione Depletion On Glycogenolysis In Isolated Rat Hepatocytes Mediated By A-Adrenoceptor Agonists And Glucagon, Mukadder Atmaca, Jeffrey R. Fry

Turkish Journal of Medical Sciences

Glutathione (GSH) exerts a variety of cytoprotecive effects, but is readily depleted from cells under a variety of stressful stimuli. The impact of GSH depletion on receptor-mediated activity in rat hepatocytes has been studied with regard to glycogenolysis stimulated with a-adrenoceptor agonists or glucagon, which exert their actions through different signalling pathways. Depletion of GSH content (70%) by diethyl maleate had no effect on the redox status of the cells or on basal or glucagon-stimulated glycogenolysis, but significantly reduced the response to the a-adrenoceptor agonists adrenalin and phenylephrine. These results highlight the possible modulatory effects of GSH on receptor-mediated activity …


The Effect Of Glutathione S-Transferase M1 Genotype On Benzo[A]Pyrene-Induced Sister Chromatid Exchanges And Chromosomal Aberrations In Peripheral Blood Lymphocytes, Gülgün S. Güven, Mehmet Güven, İlhan Onaran, Turgut Uluti̇n, Seni̇ha Hacihanefi̇oğlu Jan 2005

The Effect Of Glutathione S-Transferase M1 Genotype On Benzo[A]Pyrene-Induced Sister Chromatid Exchanges And Chromosomal Aberrations In Peripheral Blood Lymphocytes, Gülgün S. Güven, Mehmet Güven, İlhan Onaran, Turgut Uluti̇n, Seni̇ha Hacihanefi̇oğlu

Turkish Journal of Medical Sciences

Sister chromatid exchange (SCE) and chromosomal aberration (CA) in peripheral lymphocytes have been widely used in assessing exposure to mutagens and carcinogens. One of the extensively studied genotoxins is benzo[a]pyrene (BaP). The aim of the present study was to examine the ability of BaP to induce different individual cytogenetic response measured by SCE and CA frequency. The possible influence of genetic polymorphism was also taken into account, by including donors representing positive or null glutathione S-transferase M1 (GSTM1) genotypes. SCEs and CAs were analyzed from 72-h whole-blood lymphocyte cultures of 16 GSTM1 positive and 15 GSTM1 null donors after treatment …


Analysis Of Cell-Free Fetal Dna From Maternal Plasma And Serum Using A Conventional Multiplex Pcr: Factors Influencing Success, N. Lale Şatiroğlu, A. Çevi̇k Tufan, Babür Kaleli̇, Başak Yildirim, C. Nur Semerci̇, Hüseyi̇n Bağci Jan 2005

Analysis Of Cell-Free Fetal Dna From Maternal Plasma And Serum Using A Conventional Multiplex Pcr: Factors Influencing Success, N. Lale Şatiroğlu, A. Çevi̇k Tufan, Babür Kaleli̇, Başak Yildirim, C. Nur Semerci̇, Hüseyi̇n Bağci

Turkish Journal of Medical Sciences

Recent technology enables the use of cell-free fetal DNA in maternal plasma and serum for noninvasive prenatal genetic diagnosis. This study was designed to evaluate factors most likely to influence the success of a simple, cost efficient, reliable and replicable conventional PCR technique in the clinical routine of prenatal genetic diagnosis of selected cases. The results strongly suggest that DNA extraction and PCR cycle optimization are 2 major success-limiting steps and the maternal plasma is a better choice over serum for DNA extraction for such prenatal genetic diagnosis. In addition, the use of a ready-to-use PCR mixture containing heat-activated Taq …


Effects Of Oral Granisetron Treatment On Uremic Pruritus, Bülent Tokgöz, Alper Ata, Murat Si̇pahi̇oğlu, Oktay Oymak, Serap Utaş, Cengi̇z Utaş Jan 2005

Effects Of Oral Granisetron Treatment On Uremic Pruritus, Bülent Tokgöz, Alper Ata, Murat Si̇pahi̇oğlu, Oktay Oymak, Serap Utaş, Cengi̇z Utaş

Turkish Journal of Medical Sciences

The present study aimed to investigate the efficacy, safety, and tolerability of orally administered granisetron, a 5-HT_3 receptor antagonist, and its possible effect on serum histamine and serotonin levels in uremic pruritic patients who have not yet undergone dialysis. Fourteen patients with newly diagnosed end-stage renal disease were asked to complete a questionnaire about pruritus, and histamine, serotonin, PTH and cortisol levels were measured on days 0, 7 and 14. Granisetron (1 mg) was administered twice daily for 2 weeks. Plasma histamine levels were found to be up to 7 times higher in all patients and they did not change …


Remifentanil Infusion And Paracervical Block Combination For Transvaginal Ultrasound Guided Oocyte Retrieval, Kadi̇r Kaya, Ertan Öztürk, Bi̇lge Tuncer, Berri̇n Günaydin Jan 2005

Remifentanil Infusion And Paracervical Block Combination For Transvaginal Ultrasound Guided Oocyte Retrieval, Kadi̇r Kaya, Ertan Öztürk, Bi̇lge Tuncer, Berri̇n Günaydin

Turkish Journal of Medical Sciences

The optimal anesthetic technique for transvaginal ultrasound guided oocyte retrieval (TUGOR) is not known. We present a case series of patients having TUGOR under intravenous remifentanil infusion and paracervical block (PCB). One hundred four unpremedicated patients were included in our study. After monitoring heart rate (HR), mean arterial pressure (MAP), peripheral oxygen saturation (SpO_2) and end tidal CO_2 (ETCO_2), a remifentanil infusion of 0.25 µg kg^{-1} min^{-1} was started. PCB (10 ml 1% lidocaine) was performed under remifentanil infusion. As soon as the patient felt dizzy, the remifentanil infusion was decreased to 0.15 µg kg^{-1} min^{-1}. Sedation was evaluated according …


Patients' Knowledge Of The Intravenous Contrast Materials And Their Risks: A Cross-Sectional Survey, Ayli̇n Yücel, Bumi̇n Deği̇rmenci̇, Murat Acar, Hülya Elli̇dokuz, Ramazan Albayrak, Alpay Haktanir Jan 2005

Patients' Knowledge Of The Intravenous Contrast Materials And Their Risks: A Cross-Sectional Survey, Ayli̇n Yücel, Bumi̇n Deği̇rmenci̇, Murat Acar, Hülya Elli̇dokuz, Ramazan Albayrak, Alpay Haktanir

Turkish Journal of Medical Sciences

The aim of this study was to determine the level of knowledge about the intravenous contrast materials (IVCMs) and their risks in patients in an Anatolian city. The study included 156 outpatients who applied for radiographic studies requiring the use of IVCMs. The data were obtained by face-to-face interviews before the radiographic examination. The questionnaire was designed specifically for this study and the respondent was given a total score of 100 points for all correct answers. Patients' information about the IVCMs, their risks, and their role in the diagnosis of some diseases were investigated with this survey. ANOVA, t-test and …


Prevalence Of Brucellozis In The Rural Area Of Kayseri, Central Anatolia, Turkey, Fevzi̇ye Çeti̇nkaya, Meli̇s Naçar, Ayşe Nedret Koç, Selma Gökahmetoğlu, Tülay Aydin Jan 2005

Prevalence Of Brucellozis In The Rural Area Of Kayseri, Central Anatolia, Turkey, Fevzi̇ye Çeti̇nkaya, Meli̇s Naçar, Ayşe Nedret Koç, Selma Gökahmetoğlu, Tülay Aydin

Turkish Journal of Medical Sciences

This study was planned in order to make good the lack of information about population-based data on the prevalence of brucellosis in the Kayseri region. This cross-sectional research was performed on 1850 individuals living in the rural regionaround Kayseri. People aged 15-85 in 9 districts in this rural areas were interviewed and blood samples were screened using the Rose Bengal Agglutination test. The overall prevalence of brucellosis was 3.4%. Although the rate was higher in females (3.7%) than in males (2.9%), there was no significant difference. The lowest prevalence (2.0%) was observed in the 25-34 age group, and the highest …