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Tularemia Seroprevalence In Humans In The Region Of The Hittite-Arzawa War (Inner Aegean Region), Where The First Biological Weapon Was Used 3300 Years Ago, İsmai̇l Davarci, Canan Eryildiz, Duygu Perçi̇n Renders, Ufuk Berberoğlu, Şaban Gürcan Jan 2023

Tularemia Seroprevalence In Humans In The Region Of The Hittite-Arzawa War (Inner Aegean Region), Where The First Biological Weapon Was Used 3300 Years Ago, İsmai̇l Davarci, Canan Eryildiz, Duygu Perçi̇n Renders, Ufuk Berberoğlu, Şaban Gürcan

Turkish Journal of Medical Sciences

Background/aim: According to Egyptian records, tularemia emerged in the Canaan region, where it was first identified and spread to Anatolia over the Euphrates. It was used as an active biological weapon for the first time in the Hittite-Arzawa War in 1320-1318 BC. This study aimed to investigate the seroprevalence of tularemia in the Inner Aegean Region, which is thought to be the region where this war was fought 3300 years ago. Materials and methods: Tularemia seropositivity in humans was investigated in 27 villages/neighborhoods in 3 districts in each of Manisa, Kütahya, and Uşak provinces. Before the study, the participants were …


A Covid-19 First Evaluation Clinic At A University Hospital In Turkey, Gülçi̇n Telli̇ Di̇zman, Gökhan Metan, Çağlayan Merve Ayaz Ceylan, Hayri̇ye Altunay, Mertcan Uzun, Gamze Gürsoy, Zahi̇t Taş, Gi̇zem Karahan, Fari̇da Ahmadova, Tuğba Saricaoğlu, Zeynep Cansu Çalişkan, Alpaslan Alp, Meli̇ha Çağla Sönmezer, Ahmet Çağkan İnkaya, Ahmet Görkem Er Jan 2022

A Covid-19 First Evaluation Clinic At A University Hospital In Turkey, Gülçi̇n Telli̇ Di̇zman, Gökhan Metan, Çağlayan Merve Ayaz Ceylan, Hayri̇ye Altunay, Mertcan Uzun, Gamze Gürsoy, Zahi̇t Taş, Gi̇zem Karahan, Fari̇da Ahmadova, Tuğba Saricaoğlu, Zeynep Cansu Çalişkan, Alpaslan Alp, Meli̇ha Çağla Sönmezer, Ahmet Çağkan İnkaya, Ahmet Görkem Er

Turkish Journal of Medical Sciences

Background/aim: We aimed to analyze the usefulness of such a reserved area for the admission of the patients' symptoms suggesting COVID-19 and compare the demographic and clinical characteristics of the patients with COVID-19 and without COVID-19 who were admitted to C1 during the first month of the COVID-19 outbreak in our hospital. Materials and methods: A new area was set up in Hacettepe University Adult Hospital to limit the contact of COVID-19 suspicious patients with other patients, which was named as COVID-19 First Evaluation Outpatient Clinic (C1). C1 had eight isolation rooms and two sampling rooms for SARS-CoV-2 polymerase-chain-reaction (PCR). …


Covid-19 In Pediatric Nephrology Centers In Turkey, Emre Leventoğlu, Yeşi̇m Özdemi̇r Ati̇kel, Hülya Nalçacioğlu, İsmai̇l Dursun, Hasan Dursun, Zeynep Nagehan Yürük Yildirim, Nurdan Yildiz, Gülşah Kaya Aksoy, Mehmet Taşdemi̇r, Mehtap Çelakil, Belti̇nge Demi̇rci̇oğlu Kiliç, Şenay Zirhli Selçuk, Nur Canpolat, Evri̇m Kargin Çakici, Sare Gülfem Özlü Jan 2022

Covid-19 In Pediatric Nephrology Centers In Turkey, Emre Leventoğlu, Yeşi̇m Özdemi̇r Ati̇kel, Hülya Nalçacioğlu, İsmai̇l Dursun, Hasan Dursun, Zeynep Nagehan Yürük Yildirim, Nurdan Yildiz, Gülşah Kaya Aksoy, Mehmet Taşdemi̇r, Mehtap Çelakil, Belti̇nge Demi̇rci̇oğlu Kiliç, Şenay Zirhli Selçuk, Nur Canpolat, Evri̇m Kargin Çakici, Sare Gülfem Özlü

Turkish Journal of Medical Sciences

Background/aim: There is limited data on COVID-19 disease in children with kidney disease. We aimed to investigate the characteristics and prognosis of COVID-19 in pediatric nephrology patients in Turkey. Materials and methods: This was a national, multicenter, retrospective cohort study based on an online survey evaluating the data between 11th March 2020 and 11th March 2021 as an initial step of a detailed pediatric nephrology COVID-19 registry. Results: Two hundred and three patients (89 girls and 114 boys) were diagnosed with COVID-19. One-third of these patients (36.9%) were between 10-15 years old. Half of the patients were on kidney replacement …


Determination Of Covid-19 Pcr Positivity And Mutation Status In Coronavacvaccinated Individuals In Turkey, Ahmet Çalişkan, Mücahi̇t Seçme, İlknur Kaleli̇, Tuğba Sari, Sedef Zeli̇ha Öner, Sani̇ye Küçükakin Yaka, Büşra Dönmez Jan 2022

Determination Of Covid-19 Pcr Positivity And Mutation Status In Coronavacvaccinated Individuals In Turkey, Ahmet Çalişkan, Mücahi̇t Seçme, İlknur Kaleli̇, Tuğba Sari, Sedef Zeli̇ha Öner, Sani̇ye Küçükakin Yaka, Büşra Dönmez

Turkish Journal of Medical Sciences

Background/aim: CoronaVac is an inactivated virus-based COVID-19 vaccine used in Turkey and approved for emergency use by the World Health Organization (WHO). In this study, it was aimed to retrospectively evaluate the mutation status and clinical status in individuals who received two doses of CoronaVac vaccine and were infected with COVID-19 at least two weeks after the second dose. Materials and methods: 164 people were included in the study and COVID-19 diagnosis and mutation analyses were determined by RT-PCR using the Bioseepdy SARS CoV-2 Double Gene RT-qPCR Kit and the Biospeedy SARS-CoV-2 Variant Plus kit in accordance with the protocol …


Projecting The Course Of Covid-19 In Turkey: A Probabilistic Modeling Approach, Aybar Can Acar, Ahmet Görkem Er, Hüseyi̇n Cahi̇t Burduroğlu, Seher Nur Sülkü, Yeşi̇m Aydin Son, Levent Akin, Serhat Ünal Jan 2021

Projecting The Course Of Covid-19 In Turkey: A Probabilistic Modeling Approach, Aybar Can Acar, Ahmet Görkem Er, Hüseyi̇n Cahi̇t Burduroğlu, Seher Nur Sülkü, Yeşi̇m Aydin Son, Levent Akin, Serhat Ünal

Turkish Journal of Medical Sciences

Background/aim: The COVID-19 pandemic originated in Wuhan, China, in December 2019 and became one of the worst global health crises ever. While struggling with the unknown nature of this novel coronavirus, many researchers and groups attempted to project the progress of the pandemic using empirical or mechanistic models, each one having its drawbacks. The first confirmed cases were announced early in March, and since then, serious containment measures have taken place in Turkey. Materials and methods: Here, we present a different approach, a Bayesian negative binomial multilevel model with mixed effects, for the projection of the COVID-19 pandemic and we …


Turkey's Response To Covid-19 Pandemic: Strategy And Key Actions, Gülşen Barlas, Harun Öztürk, Gülen Pehli̇vantürk, Sabahatti̇n Aydin Jan 2021

Turkey's Response To Covid-19 Pandemic: Strategy And Key Actions, Gülşen Barlas, Harun Öztürk, Gülen Pehli̇vantürk, Sabahatti̇n Aydin

Turkish Journal of Medical Sciences

COVID-19 emerged at the end of 2019 in Wuhan, China, and spread rapidly around the world causing many deaths. Due to the intercontinental escalation in the epidemic, while WHO declared a pandemic on March 11, 2020, our country's first case was diagnosed. Before this, the MoH established the Operations Center against possible risks regarding the Pandemic Influenza Preparedness Plan on January 10, 2020 and formed the Scientific Committee, which has a critical importance in epidemic management. National and Provincial Pandemic Coordination Boards were established within the scope of this plan. Fast, effective and frequently updated decisions were implemented. The epidemic …


Short-Term Impact Of The Covid-19 Pandemic On The Global And Turkish Economy, Ömer Açikgöz, Asli Günay Jan 2021

Short-Term Impact Of The Covid-19 Pandemic On The Global And Turkish Economy, Ömer Açikgöz, Asli Günay

Turkish Journal of Medical Sciences

Background/aim: The Covid-19 pandemic is one of those rare events that affects everyone on earth and changes our lives. The pandemic, which has killed over four million people worldwide, is putting unprecedented pressure on governments to maintain essential health and social services, as well as keep their economies running, even as the virus threatens people's daily life on every level. Thus, the purpose of this study is to discuss the short-term economic impact of the pandemic by assessing its costs using official economic data for both the world and Turkey. Furthermore, this research highlights possible economic, social, and political pathways …


Nonpharmaceutical Interventions In Turkey And Worldwide During Covid-19 Pandemic, Mustafa Necmi̇ İlhan, Hakan Tüzün, Rahmi̇ Kiliç, Nuran Yildirim Jan 2021

Nonpharmaceutical Interventions In Turkey And Worldwide During Covid-19 Pandemic, Mustafa Necmi̇ İlhan, Hakan Tüzün, Rahmi̇ Kiliç, Nuran Yildirim

Turkish Journal of Medical Sciences

Nonpharmaceutical interventions (NPIs) are actions apart from getting vaccinated and medications, in order to promote deceleration of the spread of illness among people and communities during pandemic. In this article, we aim to examine NPIs applied in Turkey and worldwide due to the COVID-19 pandemic. Some of the NPIs such as isolation, quarantine, and contact tracing were maintained with updates of the Ministry of Health guidelines in Turkey. Some NPIs including travel and partial or full curfew mobilization restrictions were set in accordance with the various periods by the number of cases. Periods of restrictions at autumn 2021 to summer …


Detection Of Helicobacter Pylori By Invasive Tests In Adult Dyspeptic Patientsand Antibacterial Resistance To Six Antibiotics, Including Rifampicin In Turkey. Isclarithromycin Resistance Rate Decreasing?, Mustafa Akar, Fuat Aydin, Tuba Kayman, Seçi̇l Abay, Emre Karakaya Jan 2021

Detection Of Helicobacter Pylori By Invasive Tests In Adult Dyspeptic Patientsand Antibacterial Resistance To Six Antibiotics, Including Rifampicin In Turkey. Isclarithromycin Resistance Rate Decreasing?, Mustafa Akar, Fuat Aydin, Tuba Kayman, Seçi̇l Abay, Emre Karakaya

Turkish Journal of Medical Sciences

Background/aim: The prevalence of Helicobacter pylori is reported to be roughly 80% in Turkey, and only very few culture-based studies are available on antibacterial resistance in adult dyspeptic patients. This study was carried out in adult dyspeptic patients with an aim to: (i) detect H. pylori by invasive tests (culture, polymerase chain reaction, and histopathology) and (ii) determine the current resistance rates of H. pylori isolates to six antibiotics, including rifampicin. Materials and methods: This study was conducted in 422 adult dyspeptic patients. The presence of H. pylori was demonstrated by culture, polymerase chain reaction, and the histopathology of gastric …


An Evaluation Of Suspected Cases Of Hantavirus Infection Admitted To A Tertiary Care University Hospital In Düzce, Turkey, Between 2012 And 2018, Nevi̇n İnce, Kürşad Öneç, Tansu Sav, Mehmet Ali̇ Sungur, Di̇lek Menemenli̇oğlu Jan 2021

An Evaluation Of Suspected Cases Of Hantavirus Infection Admitted To A Tertiary Care University Hospital In Düzce, Turkey, Between 2012 And 2018, Nevi̇n İnce, Kürşad Öneç, Tansu Sav, Mehmet Ali̇ Sungur, Di̇lek Menemenli̇oğlu

Turkish Journal of Medical Sciences

Background/aim: Hantavirus is a rodent borne zoonosis caused by the members of the virus family Bunyaviridae, genus Hantavirus. In this study, we aimed to determine the role of peripheral blood leukocyte ratio in differential diagnosis of Hantavirus disease. Materials and methods: The medical records of patients at the Düzce University Medical Faculty were examined retrospectively. A total of 20 patients diagnosed with hantavirus infection confirmed by serologic tests were included in the study (Group 1). The other group consisted of 30 patients suspected of hantavirus infection but found negative (Group 2). Demographic, clinical and laboratory characteristics, neutrophil/lymphocyte ratio (NLR), platelet/lymphocyte …


Trends Of Sensitization To Aeroallergens In Patients With Allergic Rhinitis And Asthma Inthe City Of Bursa, South Marmara Sea Region Of Turkey, Dane Edi̇ger, Fatma Esra Günaydin, Müge Erbay, Ümmühan Şeker Jan 2020

Trends Of Sensitization To Aeroallergens In Patients With Allergic Rhinitis And Asthma Inthe City Of Bursa, South Marmara Sea Region Of Turkey, Dane Edi̇ger, Fatma Esra Günaydin, Müge Erbay, Ümmühan Şeker

Turkish Journal of Medical Sciences

Background/aim: Allergic rhinitis (AR) and asthma are the most common allergic disorders worldwide. Aeroallergens are critical causative factors in the pathogenesis of these disorders and sensitization to aeroallergens differs in various countries and regions. Identification of the most common aeroallergen sensitization is crucial in the diagnosis and management of AR and asthma. We examined the distribution of aeroallergen sensitizations detected by skin prick tests (SPTs) in adult patients with AR and/or asthma in the city of Bursa. Materials and methods: Five hundred forty-five patients who underwent a SPT and were diagnosed with rhinitis and/or asthma in the Uludağ University Faculty …


Covid-19: Prevention And Control Measures In Community, Hati̇ce Rahmet Güner, İmran Hasanoğlu, Fi̇rdevs Aktaş Jan 2020

Covid-19: Prevention And Control Measures In Community, Hati̇ce Rahmet Güner, İmran Hasanoğlu, Fi̇rdevs Aktaş

Turkish Journal of Medical Sciences

On January 30, 2020, the WHO declared the COVID-19 outbreak a public health emergency of international concern and, in March 2020, began to characterize it as a pandemic in order to emphasize the gravity of the situation and urge all countries to take action in detecting infection and preventing spread. Unfortunately, there is no medication that has been approved by the FDA, gone through controlled studies and demonstrated an effect on the virus for this global pandemic. Although there are cures for illnesses and developments made by leaps and bounds in our day, the strongest and most effective weapon that …


Covid-19 Experience Of The Major Pandemic Response Center In The Capital: Results Ofthe Pandemic's First Month In Turkey, Hati̇ce Rahmet Güner, İmran Hasanoğlu, Bi̇rcan Kayaaslan, Adalet Aypak, Ayşe Kaya Kalem, Fatma Eser, Burcu Özdemi̇r, Eli̇f Muki̇me Saricaoğlu, Müge Ayhan, Yeşi̇m Aybar Bi̇li̇r, Işil Özkoçak Turan, Deni̇z Erdem, Nevzat Mehmet Mutlu, Turan Buzğan, Bedi̇a Di̇nç Jan 2020

Covid-19 Experience Of The Major Pandemic Response Center In The Capital: Results Ofthe Pandemic's First Month In Turkey, Hati̇ce Rahmet Güner, İmran Hasanoğlu, Bi̇rcan Kayaaslan, Adalet Aypak, Ayşe Kaya Kalem, Fatma Eser, Burcu Özdemi̇r, Eli̇f Muki̇me Saricaoğlu, Müge Ayhan, Yeşi̇m Aybar Bi̇li̇r, Işil Özkoçak Turan, Deni̇z Erdem, Nevzat Mehmet Mutlu, Turan Buzğan, Bedi̇a Di̇nç

Turkish Journal of Medical Sciences

Background/aim: The aim of this study is to evaluate the epidemiological and clinical characteristics and parameters that determined the clinical course and prognosis of the COVID-19 patients admitted to Ankara City Hospital during the first month of the pandemic in Turkey. Materials and methods: SARS-CoV-2 PCR positive patients who were hospitalized between March 10 and April 10, 2020 were included. Results: Among 222 patients, mean age was higher in severe acute respiratory illness (SARI)/critical disease group (P < 0.001). Median time from illness onset to admission and presence of comorbidity, especially coronary artery disease and chronic obstructive pulmonary disease, were significantly higher in the SARI/critical disease group (P < 0.05). Cough and fever were the most common symptoms, while anosmia and loss of taste were observed in 8.6% and 7.7% patients, respectively. The mortality rate was 5.4%. A high neutrophil/lymphocyte ratio; low lymphocyte, monocyte, and platelet count; elevated liver enzymes; low GFR; and high levels of muscle enzymes, ferritin, and IL-6 on admission were found to be associated with SARI/critical disease (P < 0.05). Bilateral ground-glass opacity and patchy infiltration were more frequently seen in the SARI/critical disease group (P < 0.001). Patients older than 65 years had an 8-fold increased risk for development of SARI/critical disease. Conclusion: This cohort study regarding COVID-19 cases in Turkey reveals that older age, presence of comorbidity, bilateral infiltration on CT, high neutrophil/lymphocyte ratio, low monocyte and platelet count, elevated liver enzymes, low GFR, high levels of muscle enzymes, and high levels of ferritin and IL-6 on admission are predictors of SARI and severe disease.


Cross-Sectional Study: Long Term Follow-Up Care For Pediatric Cancer Survivors In Adeveloping Country, Turkey: Current Status, Challenges, And Future Perspectives, Sonay İncesoy Özdemi̇r, Nurdan Taçyildiz, Ali̇ Varan, Reji̇n Kebudi̇, Osman Bülent Zülfi̇kar, Tüli̇n Tiraje Celkan, Gürses Şahi̇n, Funda Vesi̇le Çorapcioğlu, Zuhal Keski̇n Yildirim, Faruk Güçlü Pinarli, Hati̇ce Nur Olgun, Neriman Sari, Ayhan Dağdemi̇r, Derya Özyörük, Tuba Eren Jan 2020

Cross-Sectional Study: Long Term Follow-Up Care For Pediatric Cancer Survivors In Adeveloping Country, Turkey: Current Status, Challenges, And Future Perspectives, Sonay İncesoy Özdemi̇r, Nurdan Taçyildiz, Ali̇ Varan, Reji̇n Kebudi̇, Osman Bülent Zülfi̇kar, Tüli̇n Tiraje Celkan, Gürses Şahi̇n, Funda Vesi̇le Çorapcioğlu, Zuhal Keski̇n Yildirim, Faruk Güçlü Pinarli, Hati̇ce Nur Olgun, Neriman Sari, Ayhan Dağdemi̇r, Derya Özyörük, Tuba Eren

Turkish Journal of Medical Sciences

Aim: The main purpose of this study is to determine the current status of long-term follow-up (LTFU) for childhood cancer survivors and the challenges of LTFU for pediatric cancer survivors at pediatric oncology institutions in Turkey. Material and methods: A questionnaire was e-mailed to the directors of 33 pediatric oncology centers (POCs) registered in the Turkish Pediatric Oncology Group (TPOG). Of these 33 active TPOG institutions, 21 participated in the study and returned their completed questionnaires. Results: Only 1 of the 21 participating centers had a separate LTFU clinic. The remaining centers provided LTFU care for childhood cancer survivors at …


The Distribution Of Mefv Mutations In Turkish Fmf Patients: Multicenter Study Representing Results Of Anatolia, Nazi̇fe Şule Yaşar Bi̇lge, İsmai̇l Sari, Di̇lek Solmaz, Abdurrahman Soner Şenel, Hakan Emmungi̇l, Levent Kiliç, Si̇bel Yilmaz Öner, Fati̇h Yildiz, Sedat Yilmaz, Emi̇ne Duygu Ersözlü, Müge Aydin Tufan, Sema Yilmaz, Veli̇ Yazisiz, Yavuz Pehli̇van, Cemal Bes Jan 2019

The Distribution Of Mefv Mutations In Turkish Fmf Patients: Multicenter Study Representing Results Of Anatolia, Nazi̇fe Şule Yaşar Bi̇lge, İsmai̇l Sari, Di̇lek Solmaz, Abdurrahman Soner Şenel, Hakan Emmungi̇l, Levent Kiliç, Si̇bel Yilmaz Öner, Fati̇h Yildiz, Sedat Yilmaz, Emi̇ne Duygu Ersözlü, Müge Aydin Tufan, Sema Yilmaz, Veli̇ Yazisiz, Yavuz Pehli̇van, Cemal Bes

Turkish Journal of Medical Sciences

Background/aim: The distribution of Mediterranean fever (MEFV) gene mutations in Turkish familial Mediterranean fever (FMF) patients varies according to geographic area of Turkey. There is a need for highly representative data for Turkish FMF patients. The aim of our study was to investigate the distribution of the common MEFV mutations in Turkish FMF patients in a nationwide, multicenter stu dy.Materials and methods: Data of the 2246 FMF patients, from 15 adult rheumatology clinics located in different parts of the country, were evaluated retrospectively. The following mutations have been tested in all patients: M694V, M680I, M694I, V726A, and E148Q.Results: There were …


Evaluation Of Being Overweight/Obese And Related Sociodemographic Factors In 0-5 Year Age Group In Turkey: Turkey Demographic Health Survey 2013 Advanced Analysis, Asi̇ye Uğraş Di̇kmen, Hande Konşuk Ünlü, Lütfi̇ye Hi̇lal Özcebe Jan 2019

Evaluation Of Being Overweight/Obese And Related Sociodemographic Factors In 0-5 Year Age Group In Turkey: Turkey Demographic Health Survey 2013 Advanced Analysis, Asi̇ye Uğraş Di̇kmen, Hande Konşuk Ünlü, Lütfi̇ye Hi̇lal Özcebe

Turkish Journal of Medical Sciences

Background/aim: To determine risk factors of overweightness/obesity in children aged 0-5 years in the Turkish population.Materials and methods: We made advanced analysis using the Turkey Demographic Health Survey (TDHS) 2013 female database, in which data from children aged under five years and their mothers are included. Analyses were performed using weight for height index data. The children were divided into two groups by age as 0-23 months and 24-59 months.Results: The analysis comprised 2196 children aged under 5 years. Several factors were associated with an increase in overweightness/obesity of children aged under 5 years. Overweight/obesity in children aged 0-23 months …


Initial Regional Evaluation Of The Cystic Fibrosis Newborn Screening Program: Data From The Mediterranean Coast Of Turkey, Abdurrahman Erdem Başaran, Ayşen Başaran, Di̇lara Fatma Kocacik, Özgül Alper, Deni̇z Acican, Ayşen Bi̇ngöl Jan 2019

Initial Regional Evaluation Of The Cystic Fibrosis Newborn Screening Program: Data From The Mediterranean Coast Of Turkey, Abdurrahman Erdem Başaran, Ayşen Başaran, Di̇lara Fatma Kocacik, Özgül Alper, Deni̇z Acican, Ayşen Bi̇ngöl

Turkish Journal of Medical Sciences

Background/ aim: Since January 2015, the Cystic Fibrosis Newborn Screening (CFNS) program has been implemented in Turkey. We aimed to evaluate the demographic, clinical, and laboratory data of cases referred from the CFNS program and to determine the most suitable cut-off value for immunoreactive trypsinogen (IRT)-1 and immunoreactive trypsinogen (IRT-2) that are used in the CFNS program in Turkey. Materials and methods: A total of 156 Turkish Caucasian subjects were determined as positive cases during 3 years, from January 2015 to January 2018, and were referred to the pediatric pulmonology clinics of Akdeniz University Hospital, Antalya, Turkey, for the national …


Distribution Of Lymphomas In Turkey: Data Of 4239 Cases From A Singleinstitution Using The Who Classification, Arzu Sağlam, Ece Esi̇n, Mutlu Hayran, Bariş Boyraz, Ayşegül Üner Jan 2018

Distribution Of Lymphomas In Turkey: Data Of 4239 Cases From A Singleinstitution Using The Who Classification, Arzu Sağlam, Ece Esi̇n, Mutlu Hayran, Bariş Boyraz, Ayşegül Üner

Turkish Journal of Medical Sciences

Background/aim: Lymphoma cases diagnosed at one of the largest tertiary reference centers in Turkey were reviewed and findings were compared to those reported from other regions of the world. Materials and methods: Lymphomas diagnosed between 2000 and 2017 in the pathology laboratory of Hacettepe University were identified. A total of 4239 cases were analyzed. The WHO 2008 classification was used. Results: Hodgkin lymphomas accounted for almost 20% of cases. T-cell lymphomas were much more frequent (23% of our non- Hodgkin lymphoma (NHL) cases) in comparison to all other regions of the world. The reason for this difference was the high …


Pooled Analysis Of 163 Published Tuberculous Peritonitis Cases From Turkey, Bedi̇a Mutay Suntur, Feri̇t Kuşcu Jan 2018

Pooled Analysis Of 163 Published Tuberculous Peritonitis Cases From Turkey, Bedi̇a Mutay Suntur, Feri̇t Kuşcu

Turkish Journal of Medical Sciences

Background/aim: Tuberculous peritonitis may be di cult to diagnose due to its insidious and variable clinical manifestations as well as characteristics similar to malignancy. In this study, case reports from Turkey over the last 10 years were reviewed systematically using pooled analysis. Materials and methods: irty-four suitable articles were found and 163 tuberculous peritonitis cases were included in the study. Results: e mean age was 34.1 years (17?79 years), and 146 (98.6%) of the patients were female and 17 (10.4%) were male. e most common complaints of these patients were abdominal pain (77.4%) and abdominal distention (73.5%). Ascites in the …


A Study Of The Chikungunya Virus In Humans In Turkey, Tuğba Atalay, Sedat Kaygusuz, Ahmet Kürşat Azkur Jan 2017

A Study Of The Chikungunya Virus In Humans In Turkey, Tuğba Atalay, Sedat Kaygusuz, Ahmet Kürşat Azkur

Turkish Journal of Medical Sciences

Background/aim: The chikungunya virus (CHIKV) is a mosquito-borne disease and has recently been causing explosive outbreaks. The CHIKV has spread throughout all continents. Although the first chikungunya case imported from India to Turkey was reported in 2012, there is no detailed epidemiologic study in Turkey yet. The aim of this study was to investigate the seroprevalence of the CHIKV in Turkey. Materials and methods: ELISA was used to screen 500 random serum samples of healthy people collected from Kırıkkale, which is located in central Anatolia in Turkey. The results were verified by indirect immunofluorescence test (IIFT). Results: The results showed …


A Fully Liquid Dtap-Ipv-Hb-Prp-T Hexavalent Vaccine For Primaryand Booster Vaccination Of Healthy Turkish Infants And Toddlers, Mehmet Ceyhan, İnci̇ Yildirim, Hasan Tezer, İlker Devri̇m, Emmanuel Feroldi Jan 2017

A Fully Liquid Dtap-Ipv-Hb-Prp-T Hexavalent Vaccine For Primaryand Booster Vaccination Of Healthy Turkish Infants And Toddlers, Mehmet Ceyhan, İnci̇ Yildirim, Hasan Tezer, İlker Devri̇m, Emmanuel Feroldi

Turkish Journal of Medical Sciences

Background/aim: Immunogenicity and safety of a primary series of a fully liquid, hexavalent DTaP-IPV-HB-PRP-T vaccine given at 2, 3, and 4 months of age compared to licensed comparators and a DTaP-IPV-HB-PRP-T booster at 15?18 months were evaluated. Materials and methods: This was a Phase III, randomized, open-label trial. Primary series (no hepatitis B [HB] at birth) of DTaP-IPV-HB-PRP-T (N = 155) (group 1) or licensed control vaccines (DTaP-IPV//PRP-T and standalone HB: N = 155) (group 2) and DTaP-IPV-HB-PRP-T booster were administered. Noninferiority was evaluated 1 month postprimary series for anti-HB seroprotection (SP). All other analyses were descriptive. Safety was assessed …


Screening Of Immunocompromised Patients At Risk Of Strongyloidiasis In Western Turkey Using Elisa And Real-Time Pcr, Esra Erdem Kivrak, Esra Atalay Şahar, Hüseyi̇n Can, Mert Döşkaya, Mümtaz Yilmaz, Hüsnü Pullukçu, Ayşe Caner, Hüseyi̇n Töz, Adnan Yüksel Gürüz, Meltem Işikgöz Taşbakan Jan 2017

Screening Of Immunocompromised Patients At Risk Of Strongyloidiasis In Western Turkey Using Elisa And Real-Time Pcr, Esra Erdem Kivrak, Esra Atalay Şahar, Hüseyi̇n Can, Mert Döşkaya, Mümtaz Yilmaz, Hüsnü Pullukçu, Ayşe Caner, Hüseyi̇n Töz, Adnan Yüksel Gürüz, Meltem Işikgöz Taşbakan

Turkish Journal of Medical Sciences

Background/aim: Strongyloides stercoralis causes life-threatening hyperinfection or disseminated strongyloidiasis in immunocompromised patients such as HIV-positive, organ transplantation, and cancer patients. This study investigated the presence of strongyloidiasis in immunocompromised patients for the first time in Turkey. Materials and methods: Serum and stool samples were collected from 108 patients (25.9% of them were chronic renal failure and 74.1% were renal transplantation patients) who were admitted to Ege University Medical School in İzmir, located in western Turkey. Serum samples were analyzed by ELISA (DRG, Germany) and the presence of 18S rRNA gene of S. stercoralis was detected in stool samples by real-time …


Frequency And Molecular Characterization Of Human Norovirus In Erzurum, Turkey, Mehmet Özkan Ti̇murkan, Hakan Aydin, Osman Aktaş Jan 2017

Frequency And Molecular Characterization Of Human Norovirus In Erzurum, Turkey, Mehmet Özkan Ti̇murkan, Hakan Aydin, Osman Aktaş

Turkish Journal of Medical Sciences

Background/aim: There are limited studies on genotyping and phylogenetic analysis of norovirus in Turkey, and this has not previously been studied in the Eastern Anatolia region. The aim of the present study was to determine the norovirus profile in this region with genotyping and phylogenetic analysis. Materials and methods: Included in the study were stool samples obtained from 427 people from different age groups in Eastern Anatolia. The nucleic acid samples isolated by the automatic system and nucleic acid sequence reactions and phylogenetic analyses were performed on RNA samples. Results: The presence of norovirus was detected in 86 (20.1%) of …


Evaluation Of The General Characteristics Of Patients Aged 85 Years And Above Admitted To A University Hospital Emergency Department, Ahmet Demi̇rcan, Şahender Gülbi̇n Aygencel Bikmaz, Gülteki̇n Kadi, Ayfer Keleş, Fi̇kret Bi̇ldi̇k, Begüm Öktem, Onur Çakmak Jan 2017

Evaluation Of The General Characteristics Of Patients Aged 85 Years And Above Admitted To A University Hospital Emergency Department, Ahmet Demi̇rcan, Şahender Gülbi̇n Aygencel Bikmaz, Gülteki̇n Kadi, Ayfer Keleş, Fi̇kret Bi̇ldi̇k, Begüm Öktem, Onur Çakmak

Turkish Journal of Medical Sciences

Background/aim: The number of elderly people ($\ge$65 years old) is increasing both in Turkey and internationally due to improved living conditions and decreased mortality rates. Knowing the characteristics of elderly patients admitted to emergency departments can provide guidance for diagnosis and treatment approaches. In this study, we analyzed the characteristics of very old patients (4$\ge$85 years old) admitted to the emergency department and put together data for use in forward planning in healthcare services.Materials and methods: This retrospective study included all patients aged $\ge$85 years admitted to the Adult Emergency Department of Gazi University Medical Faculty Hospital between 01.01.2014 and …


Isolation Rates And Antibiotic Susceptibilities Of Different Enterobacteriaceae Species As Urinary Tract Infection Agents In Turkey: A Systematic Review, Caner Yürüyen, Yeşi̇m Gürol, Sabi̇re Ferda Kaleağasioğlu, Eli̇f Çi̇ğdem Kaspar, Gülden Yilmaz Jan 2017

Isolation Rates And Antibiotic Susceptibilities Of Different Enterobacteriaceae Species As Urinary Tract Infection Agents In Turkey: A Systematic Review, Caner Yürüyen, Yeşi̇m Gürol, Sabi̇re Ferda Kaleağasioğlu, Eli̇f Çi̇ğdem Kaspar, Gülden Yilmaz

Turkish Journal of Medical Sciences

Background/aim: In Turkey, few systematic reviews have analyzed the results of studies on the isolation rates of urinary tract infection agents and their antibiotic susceptibilities. This review was done to fill this gap and enable the correct application of guideline-based medical therapy by determining the isolation rates and antibiotic susceptibilities of different Enterobacteriaceae species in Turkey. Materials and methods: Relevant studies found from various databases with the help of previously specified search strategies were examined and eliminated according to eligibility criteria. The remaining 22 studies were included in this systematic review. Results: Escherichia coli was the most frequently isolated species …


Evaluation Of Tetanus Antibody Levels In Adults In Yozgat, Turkey, Çi̇ğdem Kader, Mehmet Balci, Ayşe Erbay Jan 2016

Evaluation Of Tetanus Antibody Levels In Adults In Yozgat, Turkey, Çi̇ğdem Kader, Mehmet Balci, Ayşe Erbay

Turkish Journal of Medical Sciences

Background/aim: To assess the immune status against tetanus in relation to self-declared vaccination status among an adult population in Yozgat, Turkey. Methods: Questionnaires and blood specimens were collected from 267 individuals over 18 years of age in Yozgat, Turkey. Antitetanus antibodies were determined quantitatively by enzyme-linked immunosorbent assay. Results: Among the 267 subjects (mean age 43.4 ± 15.6; male:female, 133:134) 168 (62.9%) had protective level of tetanus antibody titers. There was a characteristic distribution of the tetanus antibody titers in different age groups as it dropped with increasing age. Protective immunity was obtained in 74.1% of urban and 47.9% of …


Determination Of Reference Range With The Indirect Method Of The 25-Hydroxyvitamind3 Test In The Balıkesir Region, Turkey, Medi̇ne Alpdemi̇r, Mehmet Fati̇h Alpdemi̇r Jan 2016

Determination Of Reference Range With The Indirect Method Of The 25-Hydroxyvitamind3 Test In The Balıkesir Region, Turkey, Medi̇ne Alpdemi̇r, Mehmet Fati̇h Alpdemi̇r

Turkish Journal of Medical Sciences

Background/aim: The aim of this study is to determine the reference ranges of 25-hydroxyvitamin D3 (25(OH)vitD3) by an indirect method using data obtained from patients over the course of 3 years. Materials and methods: The 25(OH)vitD3 test results of the patients who applied to the medical biochemistry laboratory of Balıkesir State Hospital between the years of 2010 and 2014 were analyzed. Patient data were retrospectively taken from the laboratory information system. The 25(OH)vitD3 levels of patients were examined after exclusion of outliers. Patients were divided into subgroups according to season, sex, and age. The central 95% reference intervals were calculated …


An Analysis Of The Incidence Of Measles In Turkey Since 1960, Deni̇z Çalişkan, Bi̇rgül Pi̇yal, Recep Akdur, Mi̇ne Esi̇n Ocaktan, Ceylan Yozgatligi̇l Jan 2016

An Analysis Of The Incidence Of Measles In Turkey Since 1960, Deni̇z Çalişkan, Bi̇rgül Pi̇yal, Recep Akdur, Mi̇ne Esi̇n Ocaktan, Ceylan Yozgatligi̇l

Turkish Journal of Medical Sciences

Background/aim: The aims of this study were to evaluate measles incidence and the effect of elimination strategy interventions on the disease from 1960 to 2014 in Turkey. The administration of measles vaccine started in the rural regions in 1970; it was carried out as a campaign along with the National Vaccine Campaign in 1985, and it has been employed as combined measles, mumps, and rubella under the scope of the Measles Elimination Program (MEP) since 2006 in Turkey. While a dramatic decrease in the reporting of measles was observed between 2000 and 2010, the number of the cases has increased …


Characterization Of Hcv Genotype 4d Infections In Kayseri, Turkey*, Tuba Kayman, Ceylan Polat, Gül Ergör, Yusuf Hakan Abacioğlu Jan 2015

Characterization Of Hcv Genotype 4d Infections In Kayseri, Turkey*, Tuba Kayman, Ceylan Polat, Gül Ergör, Yusuf Hakan Abacioğlu

Turkish Journal of Medical Sciences

Background/aim: The frequency of genotype 4 hepatitis C virus (HCV) infections is significantly higher in Kayseri compared to other provinces in Turkey. We aimed to characterize genotype 4 infections in Kayseri by analyzing the demographic and laboratory data of 218 HCV RNA-positive, treatment-naive patients admitted to the Kayseri Training and Research Hospital in 2010 and 2011. Materials and methods: The distributions of sex, age, and viral loads of these patients with respect to HCV genotypes were analyzed. We also characterized the type 4 sequences at the subtype level. Randomly selected sera from 32 of the 72 genotype 4 patients from …


Hepatitis C Virus Genotypes In Adana And Antakya Regions Of Turkey, Agah Bahadir Öztürk, Ümi̇t Bi̇lge Doğan, Nevi̇n Akçaer Öztürk, Gonca Özyazici, Mehmet Demi̇r, Mustafa Sali̇h Akin, Ali̇ Suha Bi̇ngöl Jan 2014

Hepatitis C Virus Genotypes In Adana And Antakya Regions Of Turkey, Agah Bahadir Öztürk, Ümi̇t Bi̇lge Doğan, Nevi̇n Akçaer Öztürk, Gonca Özyazici, Mehmet Demi̇r, Mustafa Sali̇h Akin, Ali̇ Suha Bi̇ngöl

Turkish Journal of Medical Sciences

Hepatitis C virus (HCV) genotype 1 was found to be dominant in Turkey. In this study, HCV genotypes were examined in the Adana and Antakya regions of Turkey. Materials and methods: The study consisted of 639 HCV-RNA–positive patients with chronic HCV infection in Adana (214 males and 101 females) and Antakya (139 males and 185 females) in Turkey. Real time-polymerase chain reaction was used for genotype determination. Results: In Antakya, it was determined that the percentages of genotypes of type 1a (0.31%), 1b (86.73%), 2 (9.26%), 3 (0.93%), and 4 (2.78%) were compatible with the nationwide results seen in Turkey. …