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Full-Text Articles in Medicine and Health Sciences
The Effect Of Parity, Breastfeeding History, And Duration On Clinical And Pathological Characteristics Of Breast Cancer Patients, Naziye Ak, Zeynep Tuz, Esra Aydin, Ferhat Ferhatoğlu, Murat Sari, Nail Paksoy, İzzet Doğan, Anıl Yildiz, Rian Di̇şçi̇, Pınar Mualla Sai̇p
The Effect Of Parity, Breastfeeding History, And Duration On Clinical And Pathological Characteristics Of Breast Cancer Patients, Naziye Ak, Zeynep Tuz, Esra Aydin, Ferhat Ferhatoğlu, Murat Sari, Nail Paksoy, İzzet Doğan, Anıl Yildiz, Rian Di̇şçi̇, Pınar Mualla Sai̇p
Turkish Journal of Medical Sciences
The study is aimed to determine the relationship between the delivery and breastfeeding history of the patients andthe clinicopathological properties of breast cancer.Materials and methods: A questionnaire was utilized for the study, which included the age of diagnosis, the number of children at thetime of diagnosis, the age of the children, and the breastfeeding period of each child.Results: The study included 828 patients. The median age at diagnosis was 47 years for parous women and 42 years for nonparouswomen (p < 0.001). The tumor size of the patients diagnosed within the breastfeeding period was significantly larger compared to theother patients. Estrogen and progesterone receptor positivity were lower in patients diagnosed during breastfeeding. Additionally, themean number of positive lymph nodes, dissected lymph nodes, and positive lymph node/dissected lymph node ratio in parous andbreastfed patients with a nonmetastatic disease were statistically significantly higher in multivariable analysis than those patients whowere nulliparous and have not breastfed.Conclusion: Breast cancer is seen at a later age in patients who are parous than those who have never given birth. Patients who areparous and have breastfed tend to present with a higher stage of the disease.
Dynamic Contrast-Enhanced Mammography And Breast Mri In The Diagnosis Of Breast Cancer And Detection Of Tumor Size, Muhammed Teki̇nhatun, Nuran Sabi̇r, Ergun Erdem, Sevda Yilmaz, Furkan Ufuk
Dynamic Contrast-Enhanced Mammography And Breast Mri In The Diagnosis Of Breast Cancer And Detection Of Tumor Size, Muhammed Teki̇nhatun, Nuran Sabi̇r, Ergun Erdem, Sevda Yilmaz, Furkan Ufuk
Turkish Journal of Medical Sciences
The aim of this study is to evaluate the performance of contrast-enhanced mammography (CEM) and dynamic breast MRI techniques for diagnosing breast lesions, assess the diagnostic accuracy of CEM’s using histopathological findings, and compare lesion size measurements obtained from both methods with pathological size.Materials and methods: This prospective study included 120 lesions, of which 70 were malignant, in 104 patients who underwent CEM and MRI within a week. Two radiologists independently evaluated the MR and CEM images in separate sessions, using the BI-RADS classification system. Additionally, the maximum sizes of lesion were measured. Diagnostic accuracy parameters and the receiver operating …
Acetone Extracts Of Berberis Vulgaris And Cornus Mas L. Induce Apoptosis In Mcf-7 Breast Cancer Cells, Burcu Uslu, Mustafa Yaman, Tuba Özdemi̇r Sanci, Mustafa Güngörmüş, Çağla Zübeyde Köprü, Fatma Esra Güneş
Acetone Extracts Of Berberis Vulgaris And Cornus Mas L. Induce Apoptosis In Mcf-7 Breast Cancer Cells, Burcu Uslu, Mustafa Yaman, Tuba Özdemi̇r Sanci, Mustafa Güngörmüş, Çağla Zübeyde Köprü, Fatma Esra Güneş
Turkish Journal of Medical Sciences
Background/aim: This study aimed to determine the proliferation and apoptotic effects of extracts from Cornus mas L. and Berberis vulgaris fruits on human breast cancer cells (MCF-7). Materials and methods: The Cornus mas L. and Berberis vulgaris fruits, which constitute the herbal material of the study, were turned into 80% acetone extract after washing. The total phenolic content in Berberis vulgaris fruit extracts was determined calorimetrically using Folin-Ciocalteu reagent. The spectrophotometric method was used to determine the total flavonoid amount of the extracts. In order to measure the antioxidant capacity of Cornus mas L. and Berberis vulgaris fruits and extracts, …
An Experimental Study: The Effect Of S. Boulardii On Abemaciclib-Induced Diarrhea, İbrahi̇m Ethem Cakcak, Yusuf Emre Ayti̇n, Sezi̇n Sayin, Ahmet Küçükarda, Ali̇ Gökyer, İvo Gökmen, Erkan Özcan, Selçuk Korkmaz, Ebru Taşteki̇n, İrfan Çi̇çi̇n
An Experimental Study: The Effect Of S. Boulardii On Abemaciclib-Induced Diarrhea, İbrahi̇m Ethem Cakcak, Yusuf Emre Ayti̇n, Sezi̇n Sayin, Ahmet Küçükarda, Ali̇ Gökyer, İvo Gökmen, Erkan Özcan, Selçuk Korkmaz, Ebru Taşteki̇n, İrfan Çi̇çi̇n
Turkish Journal of Medical Sciences
Background/aim: In our study, we aimed to investigate the protective effects of Saccharomyces boulardii on abemaciclib-induced diarrhea model, which is a commonly used drug in breast cancer. Materials and methods: Thirty rats were divided into 3 groups as control (Group 1), abemaciclib (Group 2), and abemaciclib + Saccharomyces boulardii (Group 3) groups. The clinical status, body weight, and defecation status were monitored daily. At the end of the 15-day experiment period, the rats were killed with high-dose anesthesia and the resected small intestine segments were evaluated histopathologically. Lesions were classified according to thickening of the villus, inflammation and edema of …
Lag-3 Expression In Tumor Microenvironment Of Triple-Negative Breast Cancer, Gözde Tahtaci, Nazan Günel, Aysu Sadi̇oğlu, Nalan Akyürek, Oğulcan Boz, Aytuğ Üner
Lag-3 Expression In Tumor Microenvironment Of Triple-Negative Breast Cancer, Gözde Tahtaci, Nazan Günel, Aysu Sadi̇oğlu, Nalan Akyürek, Oğulcan Boz, Aytuğ Üner
Turkish Journal of Medical Sciences
Background/aim: This study aimed to evaluate the expression of lymphocyte activation gene-3 (LAG-3) and its relationship with programmed cell death ligand-1 (PD-L1) in triple-negative breast cancer (TNBC). Materials and methods: LAG-3 and PD-L1 was evaluated in tumor-infiltrating lymphocytes (TILs) using immunohistochemistry (IHC). The chi-square test was used to estimate the associations between LAG-3, PD-L1 and clinicopathological characteristics. Correlation between LAG-3 stromal TIL (sTIL), LAG-3 intraepitelial TIL (iTIL) and PD-L1 was assessed with using the Spearman's correlation coefficient. Survival analysis was performed using the Kaplan-Meier method. Results: The percentages of LAG-3 sTIL+, LAG-3 iTIL+, PD-L1+ tumor cells and PD-L1+ inflammatory cells …
Pectoralis Muscle Index Might Be A Factor Associated With Frailty In Older Women With Breast Cancer, Muhammet Cemal Kizilarslanoğlu, M. Ali̇ Eryilmaz, Betül Çi̇ğdem Yortanli, İlknur Rahi̇me Ünal, Bariş Can Ünal, Nahi̇de Baran, Ayşegül Altunkeser, Nergi̇s Aksoy
Pectoralis Muscle Index Might Be A Factor Associated With Frailty In Older Women With Breast Cancer, Muhammet Cemal Kizilarslanoğlu, M. Ali̇ Eryilmaz, Betül Çi̇ğdem Yortanli, İlknur Rahi̇me Ünal, Bariş Can Ünal, Nahi̇de Baran, Ayşegül Altunkeser, Nergi̇s Aksoy
Turkish Journal of Medical Sciences
Background/aim: To investigate the possible relationship between pectoralis muscle (PM) measurement and frailty in older women with breast cancer (BC) (preoperatively defined as stage 1, 2, and 3 diseases). Materials and methods: This retrospective, observational study was conducted at Konya Training and Research Hospital between June and December 2020. A total of 102 patients [median age 62.5 years, median follow-up period two years] were included in the study. PM measurements were obtained from thorax computerized tomography (CT). Pectoralis muscle index (PMI) was calculated by dividing the PM area by the height square of the patients (cm2/m2). Pectoralis muscle density (PMD) …
Circular Rna Circprmt5 Is Upregulated In Breast Cancer And Is Required For Cellproliferation And Migration, Xiaofeng Li, Dairong Zhang, Zuxi Feng, Xiangjing Xu, Jihong Zhang, Aiping Yu, Li Zhu, Jie Xiao, Junhua Du, Min Chen
Circular Rna Circprmt5 Is Upregulated In Breast Cancer And Is Required For Cellproliferation And Migration, Xiaofeng Li, Dairong Zhang, Zuxi Feng, Xiangjing Xu, Jihong Zhang, Aiping Yu, Li Zhu, Jie Xiao, Junhua Du, Min Chen
Turkish Journal of Medical Sciences
Background/aim: To evaluate the role of cyclic protein arginine methyltransferase 5 (circPRMT5) in the occurrence and development of breast cancer (BC). Materials and methods: A total of 90 BC patients who underwent radical mastectomy and 40 age-matched healthy female controls were recruited in the Second People's Hospital of China Three Gorges University, Yichang Second People's Hospital from 2017 to 2020. Quantitative reverse transcription polymerase chain reaction (RT-qPCR) was used to detect the expression levels of circPRMT5 in BC tissues, serum, normal breast cell line (MCF-10A), and BC cell line (T47D, MCF-7, BT549, Hs-578T, and MDA-MB-231, MDAMB-468). The associations between circPRMT5 …
Predictors Of Lymphovascular Invasion In Estrogen Receptor Positive/Her-2 Negative Breast Cancer Patients Treated With Neoadjuvant Chemotherapy, Eyyüp Çavdar, Yakup İri̇ağaç
Predictors Of Lymphovascular Invasion In Estrogen Receptor Positive/Her-2 Negative Breast Cancer Patients Treated With Neoadjuvant Chemotherapy, Eyyüp Çavdar, Yakup İri̇ağaç
Turkish Journal of Medical Sciences
Background/aim: Lymphovascular invasion (LVI) is considered a high-risk factor for recurrence in early-stage breast cancer, hence examination of LVI in pathological samples is an absolute recommendation. We aim to investigate predictive factors of LVI in preneoadjuvant chemotherapy (NAC) patients with estrogen receptor positive (ER+) and human epidermal growth factor receptor 2 negative (HER2-) molecular subtypes of breast cancer. Materials and methods: One hundred and thirty-four patients treated with NAC were included in this study who were ER+/HER2-. The clinical characteristics of the patients, the data obtained from the core needle biopsy before NAC and the LVI status in the pathology …
The Validity And Clinical Utility Of Axillary Ultrasonography-Guided Fine Needle Aspiration Biopsy In Detection Of Nodal Metastasis In Early-Stage Breast Cancer Patients: A Retrospective Single-Center Experience, Fi̇li̇z Taşçi, Yavuz Meti̇n, Nurgül Orhan Meti̇n, Maksude Esra Kadioğlu, Meli̇h Gaffar Gözükara, Si̇bel Kul
The Validity And Clinical Utility Of Axillary Ultrasonography-Guided Fine Needle Aspiration Biopsy In Detection Of Nodal Metastasis In Early-Stage Breast Cancer Patients: A Retrospective Single-Center Experience, Fi̇li̇z Taşçi, Yavuz Meti̇n, Nurgül Orhan Meti̇n, Maksude Esra Kadioğlu, Meli̇h Gaffar Gözükara, Si̇bel Kul
Turkish Journal of Medical Sciences
Background/aim: Assessing the validity and clinical utility of axillary ultrasonography (AUS)-guided fine needle aspiration biopsy (FNAB) in detection of nodal metastasis during preoperative axillary investigation in comparison to the histopathologic diagnosis in early-stage breast cancer. Materials and methods: A total of 279 operated primary breast cancer patients (age: 55.3 ± 12.8, ranged 17-90 years) were included. Data on AUS findings at the time of initial diagnosis (first look AUS), second-look AUS findings performed by the breast radiologist during breast biopsy procedure and the AUS-guided FNAB findings were evaluated with respect to the final histopathology report obtained through axillary surgery via …
The Use Of Fulvestrant Before Chemotherapy Improves Survival In Hormone-Positive Breast Cancer: A Real-Life Study, Deni̇z Can Güven, Hasan Çağri Yildirim, Enes Erul, Taha Koray Şahi̇n, İbrahi̇m Yahya Çakir, Oktay Hali̇t Aktepe, Neyran Kertmen, Ömer Di̇zdar, Sercan Aksoy
The Use Of Fulvestrant Before Chemotherapy Improves Survival In Hormone-Positive Breast Cancer: A Real-Life Study, Deni̇z Can Güven, Hasan Çağri Yildirim, Enes Erul, Taha Koray Şahi̇n, İbrahi̇m Yahya Çakir, Oktay Hali̇t Aktepe, Neyran Kertmen, Ömer Di̇zdar, Sercan Aksoy
Turkish Journal of Medical Sciences
Background/aim: We aimed to evaluate the efficacy of fulvestrant and its affecting clinical factors, including the optimal sequencing of fulvestrant and chemotherapy in a real-life cohort. Methods: The data of 256 metastatic hormone-positive breast cancer patients treated with fulvestrant were evaluated. The association of clinical factors with survival was analyzed with Kaplan-Meier and Cox-regression analyses. Results: The median age of patients was 57 years. More than half of the patients used fulvestrant in later lines and after chemotherapy (75.8%). The median progression-free (PFS) and overall survival (OS) of all cohort were 6.05 ± 0.56 and 29.70 ± 1.61 months, respectively. …
Retrospective Analysis Of The Effect Of Breast Surgery On Body Posture In Patients Withearly-Stage Breast Cancer After Cancer Treatment (Venus Study)(Breast Cancer And Body Posture), Özgür Tanriverdi̇, Ahmet Ozan Çeti̇n, Ali̇ Alkan
Retrospective Analysis Of The Effect Of Breast Surgery On Body Posture In Patients Withearly-Stage Breast Cancer After Cancer Treatment (Venus Study)(Breast Cancer And Body Posture), Özgür Tanriverdi̇, Ahmet Ozan Çeti̇n, Ali̇ Alkan
Turkish Journal of Medical Sciences
Background/aim: The aim of this study was to determine whether breast surgery changes body posture in patients with early-stage breast cancer. Materials and methods: Study variables include age, side and localization of the tumor in the breast, applied breast surgery, axillary interference, pathological tumor size, axillary lymph node metastasis, body mass index, bone density, adjuvant therapies, and histological type. Thoracic kyphosis angle due to the anatomically affected primary region to detect changes in body posture and Cobb's method were used to measure this. Results: There was a statistically significant difference in the mean Cobb's angle between the follow-up times of …
Metformin Promotes Apoptosis In Primary Breast Cancer Cells By Downregulation Ofcyclin D1 And Upregulation Of P53 Through An Ampk-Alpha Independent Mechanism, Güven Yenmi̇ş, Nai̇l Beşli̇, Eli̇f Yaprak Saraç, Fatma Si̇nem Hocaoğlu Emre, Kazim Şenol, Gönül Kanigür
Metformin Promotes Apoptosis In Primary Breast Cancer Cells By Downregulation Ofcyclin D1 And Upregulation Of P53 Through An Ampk-Alpha Independent Mechanism, Güven Yenmi̇ş, Nai̇l Beşli̇, Eli̇f Yaprak Saraç, Fatma Si̇nem Hocaoğlu Emre, Kazim Şenol, Gönül Kanigür
Turkish Journal of Medical Sciences
Background/aim: In the present study we aimed to figure out the effect of metformin on the expression of AMPK-alpha, cyclin D1, and Tp53, and apoptosis in primary breast cancer cells (PBCCs). Materials and methods: PBCCs were treated with two doses of metformin (0 mM, 25 mM). Proliferation was determined by BrdU assay. Real-time PCR was used to assess AMPK-alpha, cyclin D1, and Tp53 gene expressions; apoptotic indexes of PBCCs were analyzed using flow-cytometry. Results: Twenty-four-hour incubation with 25 mM metformin reduced the proliferation of PBCCs. AMPK-alpha gene expression in PBCCs was not affected by 25 mM metformin treatment compared with …
The Study Of Sirtuins In Breast Cancer Patients Before And After Radiotherapy, Nazli Helvaci, Hati̇ce Saraçoğlu, Oğuz Gali̇p Yildiz, Eser Kiliç
The Study Of Sirtuins In Breast Cancer Patients Before And After Radiotherapy, Nazli Helvaci, Hati̇ce Saraçoğlu, Oğuz Gali̇p Yildiz, Eser Kiliç
Turkish Journal of Medical Sciences
Background/aim: Targeting the new and unique proteins is an important medical strategy for treating breast cancer. It is quite important to find out proteins that have a role in the development of cancer. Sirtuins (SIRT) are well related in different physiological activities and connected with cancer. We aimed to determine the effect of radiotherapy on SIRT1 and SIRT2, which have not been yet been clarified as a tumor suppressor or promoter. Materials and methods: Twenty-two women with nonmetastatic breast cancer enrolled in the study. Blood samples were taken before and after radiotherapy, soluble SIRT1 and SIRT2 levels were determined with …
The Evaluation Of Breast Findings Detected Through Different Visualisation Techniques Inacromegaly Patients ? A Retrospective Study, Pinar Akhanli, Sema Hepşen, Beki̇r Uçan, Hakan Düğer, Hayri̇ Bostan, Muhammed Kizilgül, Muhammed Erkam Sencar, Erman Çakal
The Evaluation Of Breast Findings Detected Through Different Visualisation Techniques Inacromegaly Patients ? A Retrospective Study, Pinar Akhanli, Sema Hepşen, Beki̇r Uçan, Hakan Düğer, Hayri̇ Bostan, Muhammed Kizilgül, Muhammed Erkam Sencar, Erman Çakal
Turkish Journal of Medical Sciences
Background/aim: It is known that the increased growth hormone (GH) and insulin-like growth factor-1 (IGF-1) have mitogenic and antiapoptotic properties in breast cells in acromegaly. Our study aims to evaluate breast findings in patients with acromegaly by comparing them to the control group. Materials and methods: Sixty-one patients followed with acromegaly diagnosis and 180 healthy controls were included in our study. Demographic data, laboratory results, Breast Imaging-Reporting and Data System (BI-RADS) scores, and breast density evaluated via mammography, malign and benign breast lesions evaluated via mammography, breast ultrasonography (USG), and breast magnetic resonance imaging (MRI) of patients were compared to …
The Association Between Mrna Expression Of Resistin, Tnf- Α, Il-6, Il-8, And Er-Α Inperipheral Blood Mononuclear Cells And Breast Cancer, Masome Zare-Moayedi, Fatame Ahmmadpour, Mojtaba Rashidi, Ahmad Ahmadzadeh, Amirahmad Salmasi, Ghorban Mohammadzadeh
The Association Between Mrna Expression Of Resistin, Tnf- Α, Il-6, Il-8, And Er-Α Inperipheral Blood Mononuclear Cells And Breast Cancer, Masome Zare-Moayedi, Fatame Ahmmadpour, Mojtaba Rashidi, Ahmad Ahmadzadeh, Amirahmad Salmasi, Ghorban Mohammadzadeh
Turkish Journal of Medical Sciences
Background/aim: Adipocytokines, adipose tissue-derived proteins, were demonstrated to be involved in the pathogenesis of breast cancer. We assessed the mRNA expression of resistin, tumor necrosis factor-alpha (TNF-α), interleukins 6 and 8 (IL-6, and IL-8), and estrogen receptor alpha (ER-α) in peripheral blood mononuclear cells (PBMCs) of women with and without breast cancer. Materials and methods: The PBMCs were isolated from the whole blood of 32 women with breast cancer and 18 women without breast cancer using density gradient centrifugation. The mRNA expression of the target genes was measured by reverse-transcription polymerase chain reaction (RT-PCR). Body mass index was calculated, additionally, …
Data-Driven Identification Of Chemopreventive Agents For Breast Cancer, Deni̇z Can Güven, Cemal Orhan, Kazi̇m Şahi̇n, Fatih Mehmet Uçkun
Data-Driven Identification Of Chemopreventive Agents For Breast Cancer, Deni̇z Can Güven, Cemal Orhan, Kazi̇m Şahi̇n, Fatih Mehmet Uçkun
Turkish Journal of Medical Sciences
Preclinical animal models of breast cancer provide the opportunity to identify chemopreventive drugs with single-agent activity as well as effective multi-modality regimens for primary as well as secondary prevention in high-risk persons. Our group has used the 7,12-dimethylbenz(a)anthracene (DMBA) mouse model of carcinogen-induced breast cancer to explore the clinical potential of two tyrosine kinase inhibitors and a nucleoside analog as chemopreventive agents. All three agents exhibited promising preclinical activity both as monotherapy and as components of combination therapy with the standard chemotherapy drug paclitaxel. The tumors developing despite chemoprevention were not only small and grew slowly, but they also displayed …
Evaluation Of Cancer Risk In Patients With Periodontal Diseases, Deni̇z Can Güven, Ömer Di̇zdar, Abdullah Cevdet Akman, Ayşe Ezel Berker, Emre Yekedüz, Furkan Ceylan, Batuhan Başpinar, Ilgin Akbiyik, Burak Yasi̇n Aktaş, Deni̇z Yüce, Mustafa Erman, Kadi̇r Mutlu Hayran
Evaluation Of Cancer Risk In Patients With Periodontal Diseases, Deni̇z Can Güven, Ömer Di̇zdar, Abdullah Cevdet Akman, Ayşe Ezel Berker, Emre Yekedüz, Furkan Ceylan, Batuhan Başpinar, Ilgin Akbiyik, Burak Yasi̇n Aktaş, Deni̇z Yüce, Mustafa Erman, Kadi̇r Mutlu Hayran
Turkish Journal of Medical Sciences
Background/aim: In this study, we aimed to assess the cancer risk among patients with periodontal disease.Materials and methods: Patients diagnosed with periodontal diseases at Hacettepe University between 2007 and 2012 were included and data on the diagnosis of any cancer after periodontal disease were collected from patient files. The age- and sex-standardized incidence rates (SIRs) were calculated using Turkish National Cancer Registry 2013 data.Results: A total of 5199 patients were included. Median follow-up was 7.2 years. Patients with periodontal diseases had 17% increased risk of cancer compared with the expected counts for the corresponding age and sex groups (SIR: 1.17; …
Treatment Results In Patients With Ductal Carcinoma In Situ Treated With Adjuvant Radiotherapy, Zeli̇ha Güzelöz Çapar, Lütfi̇ye Zümre Arican Alicikuş, Nesri̇n Aktürk, Meri̇h Güray Durak, Ali̇ İbrahi̇m Sevi̇nç, Pinar Balci, İlknur Görken
Treatment Results In Patients With Ductal Carcinoma In Situ Treated With Adjuvant Radiotherapy, Zeli̇ha Güzelöz Çapar, Lütfi̇ye Zümre Arican Alicikuş, Nesri̇n Aktürk, Meri̇h Güray Durak, Ali̇ İbrahi̇m Sevi̇nç, Pinar Balci, İlknur Görken
Turkish Journal of Medical Sciences
Background/aim: The aim of this study was to evaluate the treatment results of patients undergoing adjuvant radiotherapy (ART) after breast surgery with the diagnosis of ductal carcinoma in situ (DCIS).Materials and methods: A total of 61 women who had undergone radiotherapy following extensive surgical excision were enrolled. All patients underwent 50 Gy ART. Survival analysis was performed using Kaplan?Meier analysis and SPSS 20.0.Results: The median age was 52 years (range: 28?86). The median follow-up period after RT was 92 months (range: 23?237). The median overall survival and distant and regional recurrence-free and disease-specific survival was 96 months (range: 26?240), while …
Incidence Of Second Primary Malignancies In Patients With Thyroid Cancer In The Turkish Population, Meli̇a Karaköse, İlker Çordan, Mustafa Can, Muhammet Kocabaş, Mustafa Kulaksizoğlu, Feridun Karakurt
Incidence Of Second Primary Malignancies In Patients With Thyroid Cancer In The Turkish Population, Meli̇a Karaköse, İlker Çordan, Mustafa Can, Muhammet Kocabaş, Mustafa Kulaksizoğlu, Feridun Karakurt
Turkish Journal of Medical Sciences
Background/aim: Thyroid cancer is the most common endocrine malignancy. Recently the incidence has been increasing faster compared to other malignancies. Different studies have shown that the incidence of breast cancer in patients followed due to thyroid cancer has increased, and vice versa. The aim of this study was to evaluate the frequency of second primary cancers in the follow-up of patients with thyroid cancer.Materials and methods: In this study, 1196 patients with thyroid cancer were evaluated in the Necmettin Erbakan University Meram Medical School?s Department of Endocrinology between 2004 and 2018. Demographic characteristics and radiological and pathological results of the …
Risk Factor Assessment For Breast Cancer In North Cyprus: A Comprehensive Case-Control Study Of Turkish Cypriot Women, Ruqiya Pervaiz, Özgür Tosun, Hasan Besim, Nedi̇me Serakinci
Risk Factor Assessment For Breast Cancer In North Cyprus: A Comprehensive Case-Control Study Of Turkish Cypriot Women, Ruqiya Pervaiz, Özgür Tosun, Hasan Besim, Nedi̇me Serakinci
Turkish Journal of Medical Sciences
Background/aim: This case-control study aims to assess the strength of associations between reproductive, lifestyle, sociodemographic, and dietary factors as well as other potential breast cancer risks and breast cancer (BC) in a North Cyprus population. Materials and methods: The study includes 408 BC patients and 412 age-matched controls recruited from Near East Hospital and Dr. Burhan Nalbantoglu State Hospital in North Cyprus. Information regarding clinical and epidemiological characteristics was collected through a standardized interview. Age-adjusted odds ratios (ORs) and 95% con dence intervals (CIs) were calculated by logistic regression before and a er adjusting for the potential confounders. Results: In …
Cross-Cultural Adaptation, Reliability, And Validity Of The Turkish Version Of The Cancer Fatigue Scale In Patients With Breast Cancer, Sedef Şahi̇n, Meral Huri̇, Orkun Tahi̇r Aran, Mi̇ne Uyanik
Cross-Cultural Adaptation, Reliability, And Validity Of The Turkish Version Of The Cancer Fatigue Scale In Patients With Breast Cancer, Sedef Şahi̇n, Meral Huri̇, Orkun Tahi̇r Aran, Mi̇ne Uyanik
Turkish Journal of Medical Sciences
Background/aim: The Cancer Fatigue Scale (CFS) was developed to evaluate the severity of fatigue in patients with breast cancer. The aim of this study is to translate and culturally adapt a Turkish version and investigate the validity and reliability of the CFS in Turkish patients with fatigue symptoms. Materials and methods: Eighty participants completed the Turkish version of the CFS for breast cancer and the European Organization for Research and Treatment of Cancer Quality of Life Core Questionnaire ″Core 30″ (EORTC QLQ-C30). Test-retest reliability was evaluated by repeating the CFS with a 7-day interval. Results: The CFS demonstrated high test-retest …
Association Of Serum Leptin With Serum Estradiol In Relation To Breast Carcinogenesis: A Comparative Case-Control Study Between Pre- And Postmenopausal Women, Syed Danish Haseen Ahmed, Farah Idrees, Muhammad Ahsan, Aziza Khanam, Naheed Sultan, Naheed Akhter
Association Of Serum Leptin With Serum Estradiol In Relation To Breast Carcinogenesis: A Comparative Case-Control Study Between Pre- And Postmenopausal Women, Syed Danish Haseen Ahmed, Farah Idrees, Muhammad Ahsan, Aziza Khanam, Naheed Sultan, Naheed Akhter
Turkish Journal of Medical Sciences
Background/aim: The aims of this study were to observe the interhormonal relationship of serum leptin with serum estradiol and to compare pre- and postmenopausal women for possible implications in breast carcinogenesis. Materials and methods: This comparative case-control study encompasses 175 breast cancer patients and 175 age-, sex-, and BMI- matched healthy controls. For comparison, the subjects were divided into pre- and postmenopausal groups according to their menstrual history. Blood samples were analyzed for serum leptin and serum estradiol by the ELISA method. Results: Higher mean values of serum estrogen and leptin were observed in breast cancer cases among both the …
Detection Of Ccnd1, C-Myc, And Fgfr1 Amplification Using Modified Sybr Green Qpcr And Fish In Breast Cancer, Asaad Azarnezhad, Mina Tabrizi, Firozeh Javan, Parvin Mehdipour
Detection Of Ccnd1, C-Myc, And Fgfr1 Amplification Using Modified Sybr Green Qpcr And Fish In Breast Cancer, Asaad Azarnezhad, Mina Tabrizi, Firozeh Javan, Parvin Mehdipour
Turkish Journal of Medical Sciences
Background/aim: The aims of this study were to detect CCND1, C-MYC, and FGFR1 amplification using qPCR, confirmation with FISH, and to further assess their clinicopathological relevance. Materials and methods: Thirty-five breast tumor samples were analyzed for amplification of the selected genes using modified SYBR Green qPCR. The accuracy of the qPCR was assessed by FISH as a gold-standard method. Results: CCND1, C-MYC, and FGFR1 amplifications were observed in 34.28%, 28.57%, and 17.14% of the 35 samples, respectively. qPCR results were significantly confirmed by FISH and qPCR and FISH showed excellent correlation (P = 0.000). CCND1 amplification with tumor stage (P …
Intraoperative Boost Radiation Effects On Early Wound Complications In Breast Cancer Patients Undergoing Breast-Conserving Surgery, Mehmet Ali̇ Gülçeli̇k, Lütfi̇ Doğan, Ni̇yazi̇ Karaman, Müjdat Turan, Yavuz Seli̇m Kahraman, Gökhan Gi̇ray Akgül, Ci̇hangi̇r Özaslan
Intraoperative Boost Radiation Effects On Early Wound Complications In Breast Cancer Patients Undergoing Breast-Conserving Surgery, Mehmet Ali̇ Gülçeli̇k, Lütfi̇ Doğan, Ni̇yazi̇ Karaman, Müjdat Turan, Yavuz Seli̇m Kahraman, Gökhan Gi̇ray Akgül, Ci̇hangi̇r Özaslan
Turkish Journal of Medical Sciences
Background/aim: Intraoperative radiation therapy (IORT) may pose a risk for wound complications. All technical aspects of IORT regarding early wound complications were evaluated. Materials and methods: Ninety-three consecutive patients operated on with the same surgical technique and given (study group) or not given (control group) IORT were included. Wound complications were evaluated in two groups. Results: Forty-three patients were treated with boost dose IORT and 50 patients were treated with breast-conserving surgery without IORT. When both groups were compared in terms of early postoperative complications, there were 11 (25.5%) patients with seroma in the IORT group and 3 patients (6%) …
Concordance Of Immunohistochemistry Between Core Needle Biopsy And Surgical Resection Of Breast Cancer, Faruk Erdem Kombak, Hülya Şahi̇n, Hande Mollamemi̇şoğlu, İdri̇s Önem, Handan Kaya, Onur Buğdayci, Mustafa Erki̇n Aribal
Concordance Of Immunohistochemistry Between Core Needle Biopsy And Surgical Resection Of Breast Cancer, Faruk Erdem Kombak, Hülya Şahi̇n, Hande Mollamemi̇şoğlu, İdri̇s Önem, Handan Kaya, Onur Buğdayci, Mustafa Erki̇n Aribal
Turkish Journal of Medical Sciences
Background/aim: The purpose of this study was to evaluate the concordance of immunohistochemical (IHC) parameters of breast lesions between the core needle biopsy (CNB) and the surgical resection specimen. Materials and methods: CNB and resection specimens of female patients were retrospectively analyzed. ER, PR, HER-2, and Ki-67 parameters were compared for each patient. A total of 284 cases were assessed. Forty-one and 48 cases were excluded from the HER-2 and Ki-67 examinations, respectively, because the CNBs did not allow for IHC. Results: Concordance rates were 93.3% for ER, 89.4% for PR, 90.1% for HER-2, and 80.9% for Ki-67.Conclusion: CNB is …
The Role Of Fdg Pet/Ct In Detection Of Distant Metastasis In Theinitial Staging Of Breast Cancer, Anar Aliyev, Sabi̇re Yilmaz Aksoy, Meftune Özhan, Özgül Ekmekçi̇oğlu, Betül Vatankulu, Pinar Çi̇ğdem Kocael, Muhammet Sai̇t Sağer, Meli̇h Engi̇n Erkan, Keri̇m Sönmezoğlu, Meti̇n Halaç
The Role Of Fdg Pet/Ct In Detection Of Distant Metastasis In Theinitial Staging Of Breast Cancer, Anar Aliyev, Sabi̇re Yilmaz Aksoy, Meftune Özhan, Özgül Ekmekçi̇oğlu, Betül Vatankulu, Pinar Çi̇ğdem Kocael, Muhammet Sai̇t Sağer, Meli̇h Engi̇n Erkan, Keri̇m Sönmezoğlu, Meti̇n Halaç
Turkish Journal of Medical Sciences
Background/aim: We aimed to evaluate the role of FDG PET/CT in the detection of extraaxillary regional nodal/distant metastasis in breast cancer patients and to assess the value of FDG PET/CT for detecting distant metastases in patient subgroups. Materials and methods: A total of 254 patients with breast cancer (248 female, 6 male) who underwent PET/CT for initial staging were enrolled. Patients were divided into four groups: Group 1 consisted of 154 patients diagnosed by tru-cut/core/FNAB, Group 2 comprised 32 patients diagnosed by excisional biopsy, Group 3 included 62 patients who had mastectomy-axillary lymph node dissection, and Group 4 consisted of …
Efficacy Of Pegylated Liposomal Etoposide Nanoparticles On Breast Cancer Cell Lines, Mohammadreza Mehrabi, Parisa Esmaeilpour, Azim Akbarzadeh, Zahra Saffari, Maryam Farahnak, Ali Farhangi, Mohsen Chiani
Efficacy Of Pegylated Liposomal Etoposide Nanoparticles On Breast Cancer Cell Lines, Mohammadreza Mehrabi, Parisa Esmaeilpour, Azim Akbarzadeh, Zahra Saffari, Maryam Farahnak, Ali Farhangi, Mohsen Chiani
Turkish Journal of Medical Sciences
Background/aim: This study aimed to investigate the efficacy of pegylated liposomal etoposide nanoparticles (NPs) against T-47D and MCF-7 breast cancer cell lines. Materials and methods: Pegylated liposomal etoposide NPs were prepared by reverse phase evaporation method. The size, size distribution, and zeta potential of the NPs was measured by a Zetasizer instrument. The cytotoxicity of NPs was inspected by methyl thiazol tetrazolium assay. The release pattern of the drug from the vesicles was studied by the dialysis method. Drug loading and encapsulation efficiency (EE) were also measured. Results: The mean size, size distribution, and zeta potential of pegylated liposomal etoposide …
Combination Immunotherapy With Extract Of Heated 4t1 And Naloxone In Mouse Model Of Breast Cancer, Shervin Jahangiri, Seyyed Meysam Abtahi Froushani, Norouz Delirezh
Combination Immunotherapy With Extract Of Heated 4t1 And Naloxone In Mouse Model Of Breast Cancer, Shervin Jahangiri, Seyyed Meysam Abtahi Froushani, Norouz Delirezh
Turkish Journal of Medical Sciences
Background/aim: This study was designed to investigate the efficacy of a new vaccine against breast cancer, which was made by mixing the extract of heated 4T1 cells and naloxone, as an adjuvant. Materials and methods: Female BALB/c mice of 6-8 weeks old were challenged subcutaneously in the right flanks with 4T1 cells. When all animals developed a palpable tumor, immunotherapy was initiated. Mice in the experimental groups received, twice with a 1-week interval, either the extract of heated 4T1 alone or in combination with naloxone, and mice in the negative control group received phosphate-buffered saline. One week after the last …
Quantitative Comparison Of Immunohistochemical And Pcr Analysis Of Midkine Expression In Breast Cancer Types And Serum Midkine Level, Hülya Çeti̇n Sorkun, Meti̇n Akbulut, Yaşar Enli̇, Emre Tepeli̇, Sevgi̇ Özkan, Ergün Erdem
Quantitative Comparison Of Immunohistochemical And Pcr Analysis Of Midkine Expression In Breast Cancer Types And Serum Midkine Level, Hülya Çeti̇n Sorkun, Meti̇n Akbulut, Yaşar Enli̇, Emre Tepeli̇, Sevgi̇ Özkan, Ergün Erdem
Turkish Journal of Medical Sciences
Background/aim: Midkine (MK), a heparin-binding growth factor, has an important role in cancer progression. The aim of this study was to determine MK expression in breast tissue and the preoperative and postoperative serum levels of patients with breast cancer. Materials and methods: Sixty-one patients with breast cancer participated in our study. The MK serum levels were measured pre- and postoperatively for these patients. We also analyzed breast tissues of the 61 patients immunohistochemically. We examined serum midkine levels in 49 healthy volunteers. Results: MK expression was observed in 44 (72.1%) of 61 breast cancer patients. In breast cancer patients the …
Examination Of Factors Affecting Women?S Barrier Perception To Participate In Breast Cancer Screenings In A Region Affiliated With A Family Health Center In Turkey, Fatma Ersi̇n, Peri̇han Polat
Examination Of Factors Affecting Women?S Barrier Perception To Participate In Breast Cancer Screenings In A Region Affiliated With A Family Health Center In Turkey, Fatma Ersi̇n, Peri̇han Polat
Turkish Journal of Medical Sciences
Background/aim: This study was conducted in order to determine the factors related to women's barrier perception to participate in breast cancer screenings in a region affiliated with a family health center. Materials and methods: The study was a cross-sectional study. The sample group of the study consisted of 300 women. Descriptive statistics, t test, and Mann-Whitney U test were performed for the analysis of the data. Results: Breast self-examination (BSE) and mammography barrier perception mean score of those who were illiterate in terms of educational status, and BSE and mammography barrier perception mean score of those who were single in …