Engineering Commons^™

A Molecular Simulation Study Of Antibody-Antigen Interactions On Surfaces For The Rational Design Of Next-Generation Antibody Microarrays, Derek B. Bush

Theses and Dissertations

Antibody microarrays constitute a next-generation sensing platform that has the potential to revolutionize the way that molecular detection is conducted in many scientific fields. Unfortunately, current technologies have not found mainstream use because of reliability problems that undermine trust in their results. Although several factors are involved, it is believed that undesirable protein interactions with the array surface are a fundamental source of problems where little detail about the molecular-level biophysics are known. A better understanding of antibody stability and antibody-antigen binding on the array surface is needed to improve microarray technology. Despite the availability of many laboratory methods for …

Improving Thermodynamic Consistency Among Vapor Pressure, Heat Of Vaporization, And Liquid And Ideal Gas Heat Capacities, Joseph Wallace Hogge

Theses and Dissertations

Vapor pressure (P_vap), heat of vaporization (ΔH_vap), liquid heat capacity (C_p^l), and ideal gas heat capacity (C_p^ig) are important properties for process design and optimization. This work focuses on improving the thermodynamic consistency and accuracy of the aforementioned properties since these can drastically affect the reliability, safety, and profitability of chemical processes. They can be measured for pure organic compounds from the triple point, through the normal boiling point, and up to the critical point. Additionally, ΔH_vap is proportional to the derivative of vapor …

Multiple Target Tracking In Realistic Environments Using Recursive-Ransac In A Data Fusion Framework, Jeffrey Dyke Millard

Theses and Dissertations

Reliable track continuity is an important characteristic of multiple target tracking (MTT) algorithms. In the specific case of visually tracking multiple ground targets from an aerial platform, challenges arise due to realistic operating environments such as video compression artifacts, unmodeled camera vibration, and general imperfections in the target detection algorithm. Some popular visual detection techniques include Kanade-Lucas-Tomasi (KLT)-based motion detection, difference imaging, and object feature matching. Each of these algorithmic detectors has fundamental limitations in regard to providing consistent measurements. In this thesis we present a scalable detection framework that simultaneously leverages multiple measurement sources. We present the recursive random …

Reliability Of Feqdrain For Modeling Performance Of Sand Treated With Large-Diameter Prefabricated Drains For Liquefaction Mitigation, Travis Hatch Meservy

Theses and Dissertations

Finite element modeling of laminar shear box testing that consisted of loose sand treated with large diameter prefabricated vertical drains (PVDs), was performed. The objective of the modeling was to evaluate the reliability of the computer program FEQDrain for predicting excess pore pressure ratios (Ru) at sites treated with prefabricated drains. FEQDrain was found to be capable of successfully modeling measured excess pore pressure ratio time histories from the laminar shear box experiment, as long as an appropriate combination of €˜number of equivalent cycles and €˜shaking duration was chosen, and sensitive parameters were in the range of measured values. Hydraulic …

Eigenblades: Application Of Computer Vision And Machine Learning For Mode Shape Identification, Alex W. La

Theses and Dissertations

On August 27, 2016, Southwest Airlines flight 3472 from New Orleans to Orlando had to perform an emergency landing when a fan blade separated from the engine hub and destroyed the cowling and punctured the fuselage. Initial findings from the metallurgical examination conducted in the National Transpiration Safety Board Materials Laboratory found that the fracture surface of the missing blade showed curving crack arrest lines consistent with fatigue crack growth. Fatigue is often cause by resonate vibrations. Modal analysis is a method that can model the natural frequencies and bending modes of turbomachinery blades. When performing modal analysis with finite …

Parents' Perceptions Of Smartphone Use And Parenting Practices, David Jackson Johnson

UNLV Theses, Dissertations, Professional Papers, and Capstones

The present study is a qualitative examination aiming to gain insight into parents’ perceptions of their smartphone use and the effects it may be having on their children as well as parenting practices. Participants (N=12) were smartphone using parents that consisted mostly of young college-educated females. Thematic analysis of individual interviews resulted in five primary themes: (1) Disengagement, (2) Concern for Future, (3) Change in Social Norms, (4) Boundaries, and (5) Cognitive Dissonance. These findings indicate significant effects parental smartphone use is having in the lives of study participants. These thematic findings call for additional research examining the impact parental …

The Effects Of Exhaust Vent Location On Thermal Comfort Inside The Residential Buildings Equipped With An Evaporative Cooling System, Armin Saraei

UNLV Theses, Dissertations, Professional Papers, and Capstones

Inlet and outlet conditions, Including size and location, have significant effects on the air distribution, temperature, humidity and thermal comfort in the buildings. In the current study, various strategies are presented for exhaust air vents and the effects of inlet and outlet vents locations are evaluated on providing thermal comfort in the residential and industrial buildings. To provide thermal comfort, three key factors need to be investigated based on ASHRAE standard 55- 2013 as follows: Comfort Zone, Thermal Sensation and Draft Rate. Flow distribution is studied as well in order to investigate the strategies, which make more vorticity in the …

Managed Containers For Increased Cyber-Resilience, Xavier J. Merino Aguilera

Theses and Dissertations

Traditional defense mechanisms are no longer adequate in protecting critical infrastructure and mission critical systems. These systems require to be always-on-always-connected. High availability and data integrity become crucial to deliver their mission. Unable to guarantee uncompromisable security and given that systems will inevitably be attacked, we must change our goals to guarantee mission survivability, the ability of the system to fight through the attack. Previous work has been done to increase availability and integrity using virtual machines. We move away from virtual machines towards Linux containers and implement resiliency strategies to guarantee stateful system recovery after an attack. The goal …

Investigating The Influence Of Functional And Nonfunctional Requirements On Change And Change Propagation, Nathaniel Conde Voris

Theses and Dissertations

The research presented in this thesis investigates the nature of change and change propagation in requirement documents as they are influenced by requirement type, that is, “Functional” or “NonFunctional,” and how an understanding of these types may refine utilization of the Automated Requirement Change Propagation Prediction (ARCPP) tool when used by design teams. Functionality is determined by asking the question “Does the requirement prescribe something for the project to accomplish?” This question separates the requirements into their requisite types. Using the ARCPP, the relationship and propagation scores were determined for each requirement. Furthermore, the number of relationships were determined for …

A Comparative Analysis Of Professional Pilot Jobs, Ryan Snoeyink

Honors Theses

Professional Pilots fly aircraft for a living. Just like there are many different types of aircraft, there are many different types of professional pilot jobs. While it is an impossible task to describe every single job a professional pilot could have, there are four "groups" in which most jobs can be classified. These groups are Part 121 Scheduled Airline Service, Part 135 On-demand Charter, Part 91 Corporate/Private, and Part 61/141/142 Flight Instruction. The goal of this thesis is to examine the differences between these four groups; and by doing so, aid in the education and career decision making of those …

Comparison Of Reference Signal Received Power Measurements Between Cell Phone And Scanning Receiver In Lte, Sahin Gullu

Theses and Dissertations

In cellular technology, before giving service to customers, coverage estimation, network optimization, and maintenance rely on RSRP (Received Signal Reference Power) measurements that are collected in a given area. This measurement collection is called “drive test or drive testing” that is very common practical experiment for RF engineers. These measurements are usually recorded by a professional receiver or a professional phone with appropriate software and license. A scanning receiver, PCTEL SeeGull EX scanning Receiver in this thesis, is a common professional tool for RF engineers to collect data. A cell phone, HTC One M7 for this experiment, has an appropriate …

Efficiency Analysis And Optimization Of Light Trapping In Amorphous Silicon Heterojunction Solar Cell With Lumerical Fdtd/Device, Muhammad Riaz

Theses and Dissertations

This study investigated the two-dimensional computer analysis of a tandem solar cell: c-Si/a-Si:H/µc-SiGe, with Lumerical FDTD/DEVICE 4.6. Optical characterization was performed in FDTD and then the total generation rate was transported into DEVICE for electrical characterization. Electrical characterization of the solar cell was carried out in DEVICE. In the first stage, a single junction solar cell was studied with both a-Si and µc-SiGe, respectively, as its absorbing layers. The thickness for both layers was kept the same. For the a-Si absorbing layer Jsc = 10.959 mA/cm2 , Voc = 696.97 mV, FF = 78.985%, and η = 6.033% were achieved. …

Green Chemistry Oxidative Modification Of Peptoids Utilizing Bleach And Tempo, Jesse Leland Roberts

Graduate Theses and Dissertations

Biotherapeutic drugs, derived from biological molecules such as proteins and DNA, are becoming an integral and exceptionally critical aspect of modern medicine. Compared to common pharmaceutical drugs, biotherapeutics are much larger in size and have greater target specificity, allowing them to treat many chronic diseases ranging from cancer to rheumatoid arthritis. The major issue with protein based therapeutics is that they readily undergo proteolysis, or enzymatic degradation, when administered through subcutaneous injections. Traditionally, biotherapeutic modification procedures have centered on the use of PEG derivatives. This process, called PEGylation, is unfavorable due to the increases in molecular weights of the proteins …

Asynchronous 3d (Async3d): Design Methodology And Analysis Of 3d Asynchronous Circuits, Francis Corpuz Sabado

Graduate Theses and Dissertations

This dissertation focuses on the application of 3D integrated circuit (IC) technology on asynchronous logic paradigms, mainly NULL Convention Logic (NCL) and Multi-Threshold NCL (MTNCL). It presents the Async3D tool flow and library for NCL and MTNCL 3D ICs. It also analyzes NCL and MTNCL circuits in 3D IC. Several FIR filter designs were implement in NCL, MTNCL, and synchronous architecture to compare synchronous and asynchronous circuits in 2D and 3D ICs. The designs were normalized based on performance and several metrics were measured for comparison. Area, interconnect length, power consumption, and power density were compared among NCL, MTNCL, and …

Peptoid-Modified Bicelles As Surrogate Cell Membranes For Membrane Protein Sensors And Analytics, Helya Najafi

Graduate Theses and Dissertations

Membrane-affiliated interactions are significant in understanding cell function, detecting biomarkers to diagnose disease, and in testing the efficiency of new therapeutic targets. Model membrane systems have been developed to study membrane proteins, allowing for stable protein structure and maintaining native activity. Bicelles, disc-shaped lipid bilayers created by combining long- and short-chain phospholipids, are the model membrane system of focus in this study. Bicelles are accessible from both sides and have a wide size range, which make them attractive for studying membrane proteins without affecting function. In this work, bicelles were functionalized with two peptoids to alter the edge and face …

A Silicon Carbide Power Management Solution For High Temperature Applications, Robert Murphree

Graduate Theses and Dissertations

The increasing demand for discrete power devices capable of operating in high temperature and high voltage applications has spurred on the research of semiconductor materials with the potential of breaking through the limitations of traditional silicon. Gallium nitride (GaN) and silicon carbide (SiC), both of which are wide bandgap materials, have garnered the attention of researchers and gradually gained market share. Although these wide bandgap power devices enable more ambitious commercial applications compared to their silicon-based counterparts, reaching their potential is contingent upon developing integrated circuits (ICs) capable of operating in similar environments.

The foundation of any electrical system is …

Mppt Control For Solar Splash Photovoltaic Array, Kelsey Zenko

Mechanical Engineering Undergraduate Honors Theses

This thesis demonstrates the ability to model and simulate the operation of Maximum Power Point Tracking, MPPT. Moreover, the MPPT technology is contextualized within the confines of the Solar Splash competition to provide the foundation for future model development and simulation for optimal competition performance. MatLab Simulink was used to model the solar panel's operation. A MPPT algorithm was written using the perturb and observe method and was implemented in the model using a buck DC to DC converter. The performance of the model with hardware in the loop using Typhoon and dSPACE, which demonstrated how the actual hardware would …

Bio-Socially Inspired Strategies In Support Of Dynamic Spectrum Access: An Evolutionary Game Theory Perspective, Mohammad Ali Marzoug Abu Shattal

Dissertations

Dynamic Spectrum Access (DSA) has been introduced to fulfill the expanded need for spectrum by different wireless networks and applications. Within the realm of spectrum access, the problem of "spectrum crunch" is present since some of the spectrum bands are overcrowded and others are underutilized. DSA aims to alleviate the problem of spectrum crunch. In DSA, Primary Users (PUs) allow Secondary Users (SUs) to access the spectrum as long as they do not interfere with PU transmissions beyond a pre-agreed acceptable level. In this work, a bio-socially inspired approach is proposed for SU interactions in support of better throughput for …

Who Are Your Users? Comparing Media Professionals' Preconception Of Users To Data-Driven Personas, Lene Nielsen, Soon-Gyu Jung, Jisun An, Joni Salminen, Haewoon Kwak, Bernard J. Jansen

Research Collection School Of Computing and Information Systems

One of the reasons for using personas is to align user understandings across project teams and sites. As part of a larger persona study, at Al Jazeera English (AJE), we conducted 16 qualitative interviews with media producers, the end users of persona descriptions. We asked the participants about their understanding of a typical AJE media consumer, and the variety of answers shows that the understandings are not aligned and are built on a mix of own experiences, own self, assumptions, and data given by the company. The answers are sometimes aligned with the data-driven personas and sometimes not. The end …

Fuel Performance Modeling Of Reactivity-Initiated Accidents Using The Bison Code, Charles Pearson Folsom

All Graduate Theses and Dissertations, Spring 1920 to Summer 2023

The Fukushima Daiichi nuclear accidents in 2011 sparked considerable interest in the U.S. to develop new nuclear fuel with enhanced accident tolerance. Throughout the development of these new fuel concepts they will be extensively modeled using specialized computer codes and experimentally tested for a variety of different postulated accident scenarios. One accident scenario of interest, reactivity-initiated accident, is a nuclear reactor event involving a sudden increase in fission rate that causes a rapid increase in reactor power and temperature of the fuel which can lead to the failure of the fuel rods and are lease of radioactive material. The focus …

Demand Side Management In Smart Grid Using Big Data Analytics, Sidhant Chatterjee

All Graduate Plan B and other Reports, Spring 1920 to Spring 2023

Smart Grids are the next generation electrical grid system that utilizes smart meter-ing devices and sensors to manage the grid operations. Grid management includes the prediction of load and and classification of the load patterns and consumer usage behav-iors. These predictions can be performed using machine learning methods which are often supervised. Supervised machine learning signifies that the algorithm trains the model to efficiently predict decisions based on the previously available data.

Smart grids are employed with numerous smart meters that send user statistics to a central server. The data can be accumulated and processed using data mining and machine …

Implementing The Heston Option Pricing Model In Object-Oriented Cython, Brandon Hardin

All Graduate Plan B and other Reports, Spring 1920 to Spring 2023

The 1973 Black-Scholes model, a revolutionary option pricing formula whose price is 'relatively close to observed prices, makes an assumption that the volatility is constant and thus, deterministic. This causes some inefficiencies and patterns in the pricing of options due to the model providing evidence of the volatility smile' of the volatility. Many scholars have suggested that the volatility should be modelled by a stochastic process and the (1993) Heston Model is one of many proposed solutions to remedy this problem. The Heston Model allows for the 'smile' by defining the volatility as a stochastic process. This thesis considers a …

The Development Of Novel Interconnection Technologies For 3d Packaging Of Wire Bondless Silicon Carbide Power Modules, Sayan Seal

Graduate Theses and Dissertations

This dissertation advances the cause for the 3D packaging and integration of silicon carbide power modules. 3D wire bondless approaches adopted for enhancing the performance of silicon power modules were surveyed, and their merits were assessed to serve as a vision for the future of SiC power packaging. Current efforts pursuing 3D wire bondless SiC power modules were investigated, and the concept for a novel SiC power module was discussed. This highly-integrated SiC power module was assessed for feasibility, with a focus on achieving ultralow parasitic inductances in the critical switching loops. This will enable higher switching frequencies, leading to …

Electron Yield Measurements Of High-Yield, Low-Conductivity Dielectric Materials, Justin Christensen

All Graduate Theses and Dissertations, Spring 1920 to Summer 2023

Materials exposed to the space plasma environment acquire electric charge, which can have harmful effects if it leads to arcing or electrostatic breakdown of important spacecraft components. In fact, spacecraft charging is the leading environmentally induced cause of spacecraft anomalies. This study focuses on measuring electron yield, a property of materials that describes how many electrons are ejected from a material under energetic electron bombardment, which can vary depending on the energy of incident electrons. Intrinsic electron yield is defined as the average number of electrons emitted per incident electron from an electrically neutral material. The specific aim of this …

Effect Of Arm Motion On Standing Lateral Jump Performance, Arif Ahmed Sohel

Masters Theses

Previous jumping studies have examined the role of arm swing in vertical and horizontal long jump performance, but none have been found which studied the role of arm swing in standing lateral jumps. The purpose of this study was to investigate the effect of arm motion on standing lateral jump performance and to examine the biomechanical mechanisms that may explain differences in jump distance.

A series of lateral jump experiments was performed for two jump cases (free and restricted arms) in which six participants jumped laterally for maximum distance from two in-ground force platforms. A motion capture system collected 3D …

Query Expansion Techniques For Enterprise Search, Eric M. Domke

Masters Theses

Although web search remains an active research area, interest in enterprise search has waned. This is despite the fact that the market for enterprise search applications is expected to triple within the next six years, and that knowledge workers spend an average of 1.6 to 2.5 hours each day searching for information. To improve search relevancy, and hence reduce this time, an enterprise- focused application must be able to handle the unique queries and constraints of the enterprise environment. The goal of this thesis research was to develop, implement, and study query expansion techniques that are most effective at improving …

A Cfd Study Of A Multi-Element Front Wing For A Formula One Racing Car, Shardul C. Kachare

Masters Theses

Presently, one of the key factors in determining a success of an open wheel racecar such as Formula One or Indy car, is its aerodynamic efficiency. A modern racecar front wing can generate about 30% of the total downforce. The present study focuses on investigating the aerodynamic characteristics of such highly efficient multi-element front wing for a Formula One racecar by conducting a three-dimensional computational analysis using Reynolds Averaged Navier-Strokes model. A three-dimensional computational study is performed investigating predictive capability of the structured trimmer and unstructured polyhedral meshing model to generate a three-dimensional volume mesh for a multi-element front wing. …

Crustal Thickness Beneath Libya And The Origin Of Partial Melt Beneath As Sawda Volcanic Province From Receiver Function Constraints, Awad A. Lemnifi, Abdelsalam Elshaafi, John Browning, Nassib Aouad, Saad K. El Ebaidi, Kelly K. Liu, Agust Gudmundsson

Mining Engineering Faculty Research & Creative Works

This study investigates crustal thickness and properties within the Libyan region. Results obtained from 15 seismic stations belonging to the Libyan Center for Remote Sensing and Space Science are reported, in addition to 3 seismic stations publically available, using receiver functions. The results show crustal thicknesses ranging from 24 km to 36 km (with uncertainties ranging between ±0.10 km and ±0.90 km). More specifically, crustal thickness ranges from 32 km to 36 km in the southern portion of the Libyan territory then becomes thinner, between 24 km and 30 km, in the coastal areas of Libya and thinnest, between 24 …

Nanograin Size Effects On The Strength Of Biphase Nanolayered Composites, Sixie Huang, Irene J. Beyerlein, Caizhi Zhou

Materials Science and Engineering Faculty Research & Creative Works

In this work, we employ atomic-scale simulations to uncover the interface-driven deformation mechanisms in biphase nanolayered composites. Two internal boundaries persist in these materials, the interlayer crystalline boundaries and intralayer biphase interfaces, and both have nanoscale dimensions. These internal surfaces are known to control the activation and motion of dislocations, and despite the fact that most of these materials bear both types of interfaces. From our calculations, we find that the first defect event, signifying yield, is controlled by the intralayer spacing (grain size, d), and not the intralayer biphase spacing (layer thickness, h). The interplay of two internal sizes …

Electrospinning: Polymer Nanofibre Adsorbent Applications For Metal Ion Removal, O. K. Pereao, C. Bode-Aluko, G. Ndayambaje, O. Fatoba, L. F. Petrik

Mining Engineering Faculty Research & Creative Works

In recent decades, electro spun nanofibers have been applied to different potential fields such as sensor devices, tissue engineering scaffolds, wound dressing, filtration, drug delivery, etc. and significant review papers have been published in these fields. However, the use of electro spun nanofibers in metal ion adsorption is emerging and comparatively innovative. Nanofiber materials hold great potential in advancing the growth of metallurgical technologies and progress for the separation of metallic ions from various sources. The Physico-chemical removal processes of adsorption use nanofibers due to their large surface area to volume ratio and the availability of a wide variety of …