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Full-Text Articles in Engineering

A Design Science Approach To Investigating Decentralized Identity Technology, Janelle Krupicka Apr 2024

A Design Science Approach To Investigating Decentralized Identity Technology, Janelle Krupicka

Cybersecurity Undergraduate Research Showcase

The internet needs secure forms of identity authentication to function properly, but identity authentication is not a core part of the internet’s architecture. Instead, approaches to identity verification vary, often using centralized stores of identity information that are targets of cyber attacks. Decentralized identity is a secure way to manage identity online that puts users’ identities in their own hands and that has the potential to become a core part of cybersecurity. However, decentralized identity technology is new and continually evolving, which makes implementing this technology in an organizational setting challenging. This paper suggests that, in the future, decentralized identity …


Predictive Ai Applications For Sar Cases In The Us Coast Guard, Joshua Nelson Apr 2024

Predictive Ai Applications For Sar Cases In The Us Coast Guard, Joshua Nelson

Cybersecurity Undergraduate Research Showcase

This paper explores the potential integration of predictive analytics AI into the United States Coast Guard's (USCG) Search and Rescue Optimal Planning System (SAROPS) for deep sea and nearshore search and rescue (SAR) operations. It begins by elucidating the concept of predictive analytics AI and its relevance in military applications, particularly in enhancing SAR procedures. The current state of SAROPS and its challenges, including complexity and accuracy issues, are outlined. By integrating predictive analytics AI into SAROPS, the paper argues for streamlined operations, reduced training burdens, and improved accuracy in locating drowning personnel. Drawing on insights from military AI applications …


A Case Study Of The Crashoverride Malware, Its Effects And Possible Countermeasures, Samuel Rector Apr 2024

A Case Study Of The Crashoverride Malware, Its Effects And Possible Countermeasures, Samuel Rector

Cybersecurity Undergraduate Research Showcase

CRASHOVERRIDE is a modular malware tailor-made for electric grid Industrial Control System (ICS) equipment and was deployed by a group named ELECTRUM in a Ukrainian substation. The malware would launch a protocol exploit to flip breakers and would then wipe the system of ICS files. Finally, it would execute a Denial Of Service (DOS) attack on protective relays. In effect, months of damage and thousands out of power. However, due to oversights the malware only caused a brief power outage. Though the implications of the malware are cause for researching and implementing countermeasures against others to come. The CISA recommends …


Effect Of Resin Bleed Out On Compaction Behavior Of The Fiber Tow Gap Region During Automated Fiber Placement Manufacturing, Von Clyde Jamora, Virginia Rauch, Sergii G. Kravchenko, Oleksandr G. Kravchenko Jan 2024

Effect Of Resin Bleed Out On Compaction Behavior Of The Fiber Tow Gap Region During Automated Fiber Placement Manufacturing, Von Clyde Jamora, Virginia Rauch, Sergii G. Kravchenko, Oleksandr G. Kravchenko

Mechanical & Aerospace Engineering Faculty Publications

Automated fiber placement is a state-of-the-art manufacturing method which allows for precise control over layup design. However, AFP results in irregular morphology due to fiber tow deposition induced features such as tow gaps and overlaps. Factors such as the squeeze flow and resin bleed out, combined with large non-linear deformation, lead to morphological variability. To understand these complex interacting phenomena, a coupled multiphysics finite element framework was developed to simulate the compaction behavior around fiber tow gap regions, which consists of coupled chemo-rheological and flow-compaction analysis. The compaction analysis incorporated a visco-hyperelastic constitutive model with anisotropic tensorial prepreg viscosity, which …


A Survey On Few-Shot Class-Incremental Learning, Songsong Tian, Lusi Li, Weijun Li, Hang Ran, Xin Ning, Prayag Tiwari Jan 2024

A Survey On Few-Shot Class-Incremental Learning, Songsong Tian, Lusi Li, Weijun Li, Hang Ran, Xin Ning, Prayag Tiwari

Computer Science Faculty Publications

Large deep learning models are impressive, but they struggle when real-time data is not available. Few-shot class-incremental learning (FSCIL) poses a significant challenge for deep neural networks to learn new tasks from just a few labeled samples without forgetting the previously learned ones. This setup can easily leads to catastrophic forgetting and overfitting problems, severely affecting model performance. Studying FSCIL helps overcome deep learning model limitations on data volume and acquisition time, while improving practicality and adaptability of machine learning models. This paper provides a comprehensive survey on FSCIL. Unlike previous surveys, we aim to synthesize few-shot learning and incremental …


A Chinese Power Text Classification Algorithm Based On Deep Active Learning, Song Deng, Qianliang Li, Renjie Dai, Siming Wei, Di Wu, Yi He, Xindong Wu Jan 2024

A Chinese Power Text Classification Algorithm Based On Deep Active Learning, Song Deng, Qianliang Li, Renjie Dai, Siming Wei, Di Wu, Yi He, Xindong Wu

Computer Science Faculty Publications

The construction of knowledge graph is beneficial for grid production, electrical safety protection, fault diagnosis and traceability in an observable and controllable way. Highly-precision text classification algorithm is crucial to build a professional knowledge graph in power system. Unfortunately, there are a large number of poorly described and specialized texts in the power business system, and the amount of data containing valid labels in these texts is low. This will bring great challenges to improve the precision of text classification models. To offset the gap, we propose a classification algorithm for Chinese text in the power system based on deep …


The Feasibility Of Motion Tracking Camera System For Magnetic Suspension Wind Tunnel Tests, Hisham M. Shehata, David Cox, Mark Schoenenberger, Colin Britcher, Eli Shellabarger, Timothy Schott, Brendan Mcgovern Jan 2024

The Feasibility Of Motion Tracking Camera System For Magnetic Suspension Wind Tunnel Tests, Hisham M. Shehata, David Cox, Mark Schoenenberger, Colin Britcher, Eli Shellabarger, Timothy Schott, Brendan Mcgovern

Mechanical & Aerospace Engineering Faculty Publications

The Entry Systems Modeling (ESM) Program at NASA has actively participated in the re-development of the Magnetic Suspension Balance System (MSBS) at the six-inch subsonic wind tunnel at NASA Langley Research Center. This initiative aims to enhance the MSBS system's capabilities, enabling the testing of stingless entry vehicle models at supersonic speeds. To achieve this, control algorithms are required to ensure magnetic levitation control and stability for models during free-oscillation dynamic responses. Currently, the system relies on electromagnetic position sensors to provide real-time 3 degrees of freedom control of a rigid body. While this approach has proven successful for subsonic …


Mechanics Of Pure Bending And Eccentric Buckling In High-Strain Composite Structures, Jimesh D. Bhagatji, Oleksandr G. Kravchenko, Sharanabasaweshwara Asundi Jan 2024

Mechanics Of Pure Bending And Eccentric Buckling In High-Strain Composite Structures, Jimesh D. Bhagatji, Oleksandr G. Kravchenko, Sharanabasaweshwara Asundi

Mechanical & Aerospace Engineering Faculty Publications

To maximize the capabilities of nano- and micro-class satellites, which are limited by their size, weight, and power, advancements in deployable mechanisms with a high deployable surface area to packaging volume ratio are necessary. Without progress in understanding the mechanics of high-strain materials and structures, the development of compact deployable mechanisms for this class of satellites would be difficult. This paper presents fabrication, experimental testing, and progressive failure modeling to study the deformation of an ultra-thin composite beam. The research study examines the deformation modes of a post-deployed boom under repetitive pure bending loads using a four-point bending setup and …


Abmscore: A Heuristic Algorithm For Forming Strategic Coalitions In Agent-Based Simulation, Andrew J. Collins, Gayane Grigoryan Jan 2024

Abmscore: A Heuristic Algorithm For Forming Strategic Coalitions In Agent-Based Simulation, Andrew J. Collins, Gayane Grigoryan

Engineering Management & Systems Engineering Faculty Publications

Integrating human behavior into agent-based models has been challenging due to its diversity. An example is strategic coalition formation, which occurs when an individual decides to collaborate with others because it strategically benefits them, thereby increasing the expected utility of the situation. An algorithm called ABMSCORE was developed to help model strategic coalition formation in agent-based models. The ABMSCORE algorithm employs hedonic games from cooperative game theory and has been applied to various situations, including refugee egress and smallholder farming cooperatives. This paper discusses ABMSCORE, including its mechanism, requirements, limitations, and application. To demonstrate the potential of ABMSCORE, a new …


Advancements And Challenges In Additively Manufactured Functionally Graded Materials: A Comprehensive Review, Suhas Alkunte, Ismail Fidan, Vivekanand Naikwadi, Shamil Gudavasov, Mohammad Alshaikh Ali, Mushfig Mahmudov, Seymur Hasanov, Muralimohan Cheepu Jan 2024

Advancements And Challenges In Additively Manufactured Functionally Graded Materials: A Comprehensive Review, Suhas Alkunte, Ismail Fidan, Vivekanand Naikwadi, Shamil Gudavasov, Mohammad Alshaikh Ali, Mushfig Mahmudov, Seymur Hasanov, Muralimohan Cheepu

Engineering Technology Faculty Publications

This paper thoroughly examines the advancements and challenges in the field of additively manufactured Functionally Graded Materials (FGMs). It delves into conceptual approaches for FGM design, various manufacturing techniques, and the materials employed in their fabrication using additive manufacturing (AM) technologies. This paper explores the applications of FGMs in diverse fields, including structural engineering, automotive, biomedical engineering, soft robotics, electronics, 4D printing, and metamaterials. Critical issues and challenges associated with FGMs are meticulously analyzed, addressing concerns related to production and performance. Moreover, this paper forecasts future trends in FGM development, highlighting potential impacts on diverse industries. The concluding section summarizes …


Designing High-Performance Identity-Based Quantum Signature Protocol With Strong Security, Sunil Prajapat, Pankaj Kumar, Sandeep Kumar, Ashok Kumar Das, Sachin Shetty, M. Shamim Hossain Jan 2024

Designing High-Performance Identity-Based Quantum Signature Protocol With Strong Security, Sunil Prajapat, Pankaj Kumar, Sandeep Kumar, Ashok Kumar Das, Sachin Shetty, M. Shamim Hossain

VMASC Publications

Due to the rapid advancement of quantum computers, there has been a furious race for quantum technologies in academia and industry. Quantum cryptography is an important tool for achieving security services during quantum communication. Designated verifier signature, a variant of quantum cryptography, is very useful in applications like the Internet of Things (IoT) and auctions. An identity-based quantum-designated verifier signature (QDVS) scheme is suggested in this work. Our protocol features security attributes like eavesdropping, non-repudiation, designated verification, and hiding sources attacks. Additionally, it is protected from attacks on forgery, inter-resending, and impersonation. The proposed scheme benefits from the traditional designated …


Tailored Micromagnet Sorting Gate For Simultaneous Multiple Cell Screening In Portable Magnetophoretic Cell-On-Chip Platforms, Jonghwan Yoon, Yumin Kang, Hyeonseol Kim, Abbas Ali, Keonmok Kim, Sri Ramulu Torati, Mi-Young Im, Changyeop Jeon, Byeonghwa Lim, Cheolgi Kim Jan 2024

Tailored Micromagnet Sorting Gate For Simultaneous Multiple Cell Screening In Portable Magnetophoretic Cell-On-Chip Platforms, Jonghwan Yoon, Yumin Kang, Hyeonseol Kim, Abbas Ali, Keonmok Kim, Sri Ramulu Torati, Mi-Young Im, Changyeop Jeon, Byeonghwa Lim, Cheolgi Kim

Bioelectronics Publications

Conventional magnetophoresis techniques for manipulating biocarriers and cells predominantly rely on large-scale electromagnetic systems, which is a major obstacle to the development of portable and miniaturized cell-on-chip platforms. Herein, a novel magnetic engineering approach by tailoring a nanoscale notch on a disk micromagnet using two-step optical and thermal lithography is developed. Versatile manipulations are demonstrated, such as separation and trapping, of carriers and cells by mediating changes in the magnetic domain structure and discontinuous movement of magnetic energy wells around the circumferential edge of the micromagnet caused by a locally fabricated nano-notch in a low magnetic field system. The motion …


Quantification Of Antiviral Drug Tenofovir (Tfv) By Surface-Enhanced Raman Spectroscopy (Sers) Using Cumulative Distribution Functions (Cdfs), Marguerite R. Butler, Jana Hrncirova, Meredith Clark, Sucharita Dutta, John B. Cooper Jan 2024

Quantification Of Antiviral Drug Tenofovir (Tfv) By Surface-Enhanced Raman Spectroscopy (Sers) Using Cumulative Distribution Functions (Cdfs), Marguerite R. Butler, Jana Hrncirova, Meredith Clark, Sucharita Dutta, John B. Cooper

Chemistry & Biochemistry Faculty Publications

Surface-enhanced Raman spectroscopy (SERS) is an ultrasensitive spectroscopic technique that generates signal-enhanced fingerprint vibrational spectra of small molecules. However, without rigorous control of SERS substrate active sites, geometry, surface area, or surface functionality, SERS is notoriously irreproducible, complicating the consistent quantitative analysis of small molecules. While evaporatively prepared samples yield significant SERS enhancement resulting in lower detection limits, the distribution of these enhancements along the SERS surface is inherently stochastic. Acquiring spatially resolved SERS spectra of these dried surfaces, we have shown that this enhancement is governed by a power law as a function of analyte concentration. Consequently, by definition, …


Triphlapan: Predicting Hla Molecules Binding Peptides Based On Triple Coding Matrix And Transfer Learning, Meng Wang, Chuqi Lei, Jianxin Wang, Yaohang Li, Min Li Jan 2024

Triphlapan: Predicting Hla Molecules Binding Peptides Based On Triple Coding Matrix And Transfer Learning, Meng Wang, Chuqi Lei, Jianxin Wang, Yaohang Li, Min Li

Computer Science Faculty Publications

Human leukocyte antigen (HLA) recognizes foreign threats and triggers immune responses by presenting peptides to T cells. Computationally modeling the binding patterns between peptide and HLA is very important for the development of tumor vaccines. However, it is still a big challenge to accurately predict HLA molecules binding peptides. In this paper, we develop a new model TripHLApan for predicting HLA molecules binding peptides by integrating triple coding matrix, BiGRU + Attention models, and transfer learning strategy. We have found the main interaction site regions between HLA molecules and peptides, as well as the correlation between HLA encoding and binding …


Applications Of Ai/Ml In Maritime Cyber Supply Chains, Rafael Diaz, Ricardo Ungo, Katie Smith, Lida Haghnegahdar, Bikash Singh, Tran Phuong Jan 2024

Applications Of Ai/Ml In Maritime Cyber Supply Chains, Rafael Diaz, Ricardo Ungo, Katie Smith, Lida Haghnegahdar, Bikash Singh, Tran Phuong

School of Cybersecurity Faculty Publications

Digital transformation is a new trend that describes enterprise efforts in transitioning manual and likely outdated processes and activities to digital formats dominated by the extensive use of Industry 4.0 elements, including the pervasive use of cyber-physical systems to increase efficiency, reduce waste, and increase responsiveness. A new domain that intersects supply chain management and cybersecurity emerges as many processes as possible of the enterprise require the convergence and synchronizing of resources and information flows in data-driven environments to support planning and execution activities. Protecting the information becomes imperative as big data flows must be parsed and translated into actions …


Anonymous Attribute-Based Broadcast Encryption With Hidden Multiple Access Structures, Tran Viet Xuan Phuong Jan 2024

Anonymous Attribute-Based Broadcast Encryption With Hidden Multiple Access Structures, Tran Viet Xuan Phuong

School of Cybersecurity Faculty Publications

Due to the high demands of data communication, the broadcasting system streams the data daily. This service not only sends out the message to the correct participant but also respects the security of the identity user. In addition, when delivered, all the information must be protected for the party who employs the broadcasting service. Currently, Attribute-Based Broadcast Encryption (ABBE) is useful to apply for the broadcasting service. (ABBE) is a combination of Attribute-Based Encryption (ABE) and Broadcast Encryption (BE), which allows a broadcaster (or encrypter) to broadcast an encrypted message, including a predefined user set and specified access policy to …


Urban Flood Extent Segmentation And Evaluation From Real-World Surveillance Camera Images Using Deep Convolutional Neural Network, Yidi Wang, Yawen Shen, Behrouz Salahshour, Mecit Cetin, Khan Iftekharuddin, Navid Tahvildari, Guoping Huang, Devin K. Harris, Kwame Ampofo, Jonathan L. Goodall Jan 2024

Urban Flood Extent Segmentation And Evaluation From Real-World Surveillance Camera Images Using Deep Convolutional Neural Network, Yidi Wang, Yawen Shen, Behrouz Salahshour, Mecit Cetin, Khan Iftekharuddin, Navid Tahvildari, Guoping Huang, Devin K. Harris, Kwame Ampofo, Jonathan L. Goodall

Civil & Environmental Engineering Faculty Publications

This study explores the use of Deep Convolutional Neural Network (DCNN) for semantic segmentation of flood images. Imagery datasets of urban flooding were used to train two DCNN-based models, and camera images were used to test the application of the models with real-world data. Validation results show that both models extracted flood extent with a mean F1-score over 0.9. The factors that affected the performance included still water surface with specular reflection, wet road surface, and low illumination. In testing, reduced visibility during a storm and raindrops on surveillance cameras were major problems that affected the segmentation of flood extent. …


A Review On Biochar As An Adsorbent For Pb(Ii) Removal From Water, Pushpita Kumkum, Sandeep Kumar Jan 2024

A Review On Biochar As An Adsorbent For Pb(Ii) Removal From Water, Pushpita Kumkum, Sandeep Kumar

Civil & Environmental Engineering Faculty Publications

Heavy metal contamination in drinking water is a growing concern due to its severe health effects on humans. Among the many metals, lead (Pb), which is a toxic and harmful element, has the most widespread global distribution. Pb pollution is a major problem of water pollution in developing countries and nations. The most common sources of lead in drinking water are lead pipes, faucets, and plumbing fixtures. Adsorption is the most efficient method for metal removal, and activated carbon has been used widely in many applications as an effective adsorbent, but its high production costs have created the necessity for …


Autonomous Strike Uavs For Counterterrorism Missions: Challenges And Preliminary Solutions, Meshari Aljohani, Ravi Mukkamala, Stephan Olariu Jan 2024

Autonomous Strike Uavs For Counterterrorism Missions: Challenges And Preliminary Solutions, Meshari Aljohani, Ravi Mukkamala, Stephan Olariu

Computer Science Faculty Publications

UAVs are becoming a crucial tool in modern warfare, primarily due to their cost-effectiveness, risk reduction, and ability to perform a wider range of activities. The use of autonomous UAVs to conduct strike missions against highly valuable targets is the focus of this research. Due to developments in ledger technology, smart contracts, and machine learning, such activities formerly carried out by professionals or remotely flown UAVs are now feasible. Our study provides the first in-depth analysis of challenges and potential solutions for successful implementation of an autonomous UAV mission.


Photoluminescence Switching In Quantum Dots Connected With Fluorinated And Hydrogenated Photochromic Molecules, Ephraiem S. Sarabamoun, Jonathan M. Bietsch, Pramod Aryal, Amelia G. Reid, Maurice Curran, Grayson Johnson, Esther H. R. Tsai, Charles W. Machan, Guijun Wang, Joshua J. Choi Jan 2024

Photoluminescence Switching In Quantum Dots Connected With Fluorinated And Hydrogenated Photochromic Molecules, Ephraiem S. Sarabamoun, Jonathan M. Bietsch, Pramod Aryal, Amelia G. Reid, Maurice Curran, Grayson Johnson, Esther H. R. Tsai, Charles W. Machan, Guijun Wang, Joshua J. Choi

Chemistry & Biochemistry Faculty Publications

We investigate switching of photoluminescence (PL) from PbS quantum dots (QDs) crosslinked with two different types of photochromic diarylethene molecules, 4,4'-(1-cyclopentene-1,2-diyl)bis[5-methyl-2-thiophenecarboxylic acid] (1H) and 4,4'-(1-perfluorocyclopentene-1,2-diyl)bis[5-methyl-2-thiophenecarboxylic acid] (2F). Our results show that the QDs crosslinked with the hydrogenated molecule (1H) exhibit a greater amount of switching in photoluminescence intensity compared to QDs crosslinked with the fluorinated molecule (2F). With a combination of differential pulse voltammetry and density functional theory, we attribute the different amount of PL switching to the different energy levels between 1H and 2F molecules which result in different potential barrier …


Small-Strain Site Response Of Soft Soils In The Sacramento-San Joaquin Delta Region Of California Conditioned On Vₛ₃₀ And Mhvsr, Tristan E. Buckreis, Jonathan P. Stewart, Scott J. Brandenberg, Pengfei Wang Jan 2024

Small-Strain Site Response Of Soft Soils In The Sacramento-San Joaquin Delta Region Of California Conditioned On Vₛ₃₀ And Mhvsr, Tristan E. Buckreis, Jonathan P. Stewart, Scott J. Brandenberg, Pengfei Wang

Civil & Environmental Engineering Faculty Publications

Sites located in the Sacramento-San Joaquin Delta region of California typically have peaty-organic soils near the ground surface, which are characteristically soft, with shear wave velocities as low as 30 m/s. These unusually soft geotechnical conditions, which are outside the range of applicability of existing ergodic site amplification models, can be anticipated to produce significant site effects during earthquake shaking. We evaluate site response for 36 seismic stations in the Delta region using non-ergodic methods with low-amplitude ground motion data. We model first-order site effects using a period-dependent relation conditioned on the 30 m time-averaged shear wave velocity (V …


Methods That Support The Validation Of Agent-Based Models: An Overview And Discussion, Andrew Collins, Matthew Koehler, Christopher Lynch Jan 2024

Methods That Support The Validation Of Agent-Based Models: An Overview And Discussion, Andrew Collins, Matthew Koehler, Christopher Lynch

Engineering Management & Systems Engineering Faculty Publications

Validation is the process of determining if a model adequately represents the system under study for the model’s intended purpose. Validation is a critical component in building the credibility of a simulation model with its end-users. Effectively conducting validation can be a daunting task for both novice and experienced simulation developers. Further compounding the difficult task of conducting validation is that there is no universally accepted approach for assessing a simulation. These challenges are particularly relevant to the paradigm of Agent-Based Modeling and Simulation (ABMS) because of the complexity found in these models’ mechanisms and in the real-world situations they …


A New Cache Replacement Policy In Named Data Network Based On Fib Table Information, Mehran Hosseinzadeh, Neda Moghim, Samira Taheri, Nasrin Gholami Jan 2024

A New Cache Replacement Policy In Named Data Network Based On Fib Table Information, Mehran Hosseinzadeh, Neda Moghim, Samira Taheri, Nasrin Gholami

VMASC Publications

Named Data Network (NDN) is proposed for the Internet as an information-centric architecture. Content storing in the router’s cache plays a significant role in NDN. When a router’s cache becomes full, a cache replacement policy determines which content should be discarded for the new content storage. This paper proposes a new cache replacement policy called Discard of Fast Retrievable Content (DFRC). In DFRC, the retrieval time of the content is evaluated using the FIB table information, and the content with less retrieval time receives more discard priority. An impact weight is also used to involve both the grade of retrieval …


Plasma Protein Signatures Of Adult Asthma, Gordon J. Smilnak, Yura Lee, Abhijnan Chattopadhyay, Annah B. Wyss, Julie D. White, Sinjini Sikdar, Jianping Jin, Andrew J. Grant, Alison A. Motsinger-Reif, Jian-Liang Li, Mikyeong Lee, Bing Yu, Stephanie J. London Jan 2024

Plasma Protein Signatures Of Adult Asthma, Gordon J. Smilnak, Yura Lee, Abhijnan Chattopadhyay, Annah B. Wyss, Julie D. White, Sinjini Sikdar, Jianping Jin, Andrew J. Grant, Alison A. Motsinger-Reif, Jian-Liang Li, Mikyeong Lee, Bing Yu, Stephanie J. London

Mathematics & Statistics Faculty Publications

Background: Adult asthma is complex and incompletely understood. Plasma proteomics is an evolving technique that can both generate biomarkers and provide insights into disease mechanisms. We aimed to identify plasma proteomic signatures of adult asthma.

Methods: Protein abundance in plasma was measured in individuals from the Agricultural Lung Health Study (ALHS) (761 asthma, 1095 non-case) and the Atherosclerosis Risk in Communities study (470 asthma, 10,669 non-case) using the SOMAScan 5K array. Associations with asthma were estimated using covariate adjusted logistic regression and meta-analyzed using inverse-variance weighting. Additionally, in ALHS, we examined phenotypes based on both asthma and seroatopy (asthma with …


Synergistic Effects Of Nanosecond Pulsed Plasma And Electric Field On Inactivation Of Pancreatic Cancer Cells In Vitro, Edwin A. Oshin, Zobia Minhas, Ruben M. L. Colunga Biancatelli, John D. Catravas, Richard Heller, Siqi Guo, Chunqi Jiang Jan 2024

Synergistic Effects Of Nanosecond Pulsed Plasma And Electric Field On Inactivation Of Pancreatic Cancer Cells In Vitro, Edwin A. Oshin, Zobia Minhas, Ruben M. L. Colunga Biancatelli, John D. Catravas, Richard Heller, Siqi Guo, Chunqi Jiang

Bioelectrics Publications

Nanosecond pulsed atmospheric pressure plasma jets (ns-APPJs) produce reactive plasma species, including charged particles and reactive oxygen and nitrogen species (RONS), which can induce oxidative stress in biological cells. Nanosecond pulsed electric field (nsPEF) has also been found to cause permeabilization of cell membranes and induce apoptosis or cell death. Combining the treatment of ns-APPJ and nsPEF may enhance the effectiveness of cancer cell inactivation with only moderate doses of both treatments. Employing ns-APPJ powered by 9 kV, 200 ns pulses at 2 kHz and 60-nsPEF of 50 kV/cm at 1 Hz, the synergistic effects on pancreatic cancer cells (Pan02) …


Nanosecond Pulsed Electric Fields Increase Antibiotic Susceptibility In Methicillin-Resistant Staphylococcus Aureus, Alexandra E. Chittams-Miles, Areej Malik, Erin B. Purcell, Claudia Muratori Jan 2024

Nanosecond Pulsed Electric Fields Increase Antibiotic Susceptibility In Methicillin-Resistant Staphylococcus Aureus, Alexandra E. Chittams-Miles, Areej Malik, Erin B. Purcell, Claudia Muratori

Bioelectrics Publications

Staphylococcus aureus is the leading cause of skin and soft-tissue infections (SSTIs). SSTIs caused by bacteria resistant to antimicrobials, such as methicillin-resistant S. aureus (MRSA), are increasing in incidence and have led to higher rates of hospitalization. In this study, we measured MRSA inactivation by nanosecond pulsed electric fields (nsPEF), a promising new cell ablation technology. Our results show that treatment with 120 pulses of 600 ns duration (28 kV/cm, 1 Hz), caused modest inactivation, indicating cellular damage. We anticipated that the perturbation created by nsPEF could increase antibiotic efficacy if nsPEF were applied as a co-treatment. To test this …


Decompositions Of Nonlinear Input-Output Systems To Zero The Output, W. Steven Gray, Kurusch Ebrahimi-Fard, Alexander Schmeding Jan 2024

Decompositions Of Nonlinear Input-Output Systems To Zero The Output, W. Steven Gray, Kurusch Ebrahimi-Fard, Alexander Schmeding

Electrical & Computer Engineering Faculty Publications

Consider an input–output system where the output is the tracking error given some desired reference signal. It is natural to consider under what conditions the problem has an exact solution, that is, the tracking error is exactly the zero function. If the system has a well defined relative degree and the zero function is in the range of the input–output map, then it is well known that the system is locally left invertible, and thus, the problem has a unique exact solution. A system will fail to have relative degree when more than one exact solution exists. The general goal …


From Carnival Games To Plastic Filters: Preparing Elementary Preservice Teachers To Teach Engineering, Jennifer Kidd, Pilar Pazos, Kristie Gutierrez, Danielle Rhemer, Stacie Ringleb, Krishna Kaipa, Isaac Kumi, Orlando Ayala, Francisco Cima Jan 2024

From Carnival Games To Plastic Filters: Preparing Elementary Preservice Teachers To Teach Engineering, Jennifer Kidd, Pilar Pazos, Kristie Gutierrez, Danielle Rhemer, Stacie Ringleb, Krishna Kaipa, Isaac Kumi, Orlando Ayala, Francisco Cima

Teaching & Learning Faculty Publications

Preservice teachers (PSTs) in an educational foundations course were tasked with leading elementary students in an engineering design challenge. In order to explore different approaches for helping the PSTs develop competence in engineering education, two implementation methods were tested. In Spring 2022, PSTs collaborated with undergraduate engineering students to develop carnival-themed design challenge lessons. In Fall 2022, PSTs worked with their PST classmates to teach a professionally prepared engineering lesson focused on designing plastic filters. PSTs’ knowledge of engineering and engineering pedagogy were compared across the two semesters using an exploratory approach. Both groups showed increases in engineering knowledge and …


Underlying Substrate Effect On Electrochemical Activity For Hydrogen Evolution Reaction With Low-Platinum-Loaded Catalysts, Baleeswaraiah Muchharla, Peter V. Sushko, Kishor K. Sadasivuni, Wei Cao, Akash Tomar, Hani Elsayed-Ali, Adetayo Adedeji, Abdennaceur Karoui, Joshua M. Spurgeon, Bijandra Kumar Jan 2024

Underlying Substrate Effect On Electrochemical Activity For Hydrogen Evolution Reaction With Low-Platinum-Loaded Catalysts, Baleeswaraiah Muchharla, Peter V. Sushko, Kishor K. Sadasivuni, Wei Cao, Akash Tomar, Hani Elsayed-Ali, Adetayo Adedeji, Abdennaceur Karoui, Joshua M. Spurgeon, Bijandra Kumar

Electrical & Computer Engineering Faculty Publications

Platinum is known as the best catalyst for the hydrogen evolution reaction (HER) but the scarcity and high cost of Pt limit its widespread applicability. Herein, the role of the underlying substrate on the HER activity of dispersed Pt atoms is uncovered. A direct current magnetron sputtering technique is utilized to deposit transition metal (TM) thin films of W, Ti, and Ta as underlying substrates for extremely low loading of Pt (


Identification And Characterization Of Two Novel Kcnh2 Mutations Contributing To Long Qt Syndrome, Anthony Owusu-Mensah, Jacqueline Treat, Joyce Bernardi, Ryan Pfeiffer, Robert Goodrow, Bright Tsevi, Victoria Lam, Michel Audette, Jonathan M. Cordeiro, Makarand Deo Jan 2024

Identification And Characterization Of Two Novel Kcnh2 Mutations Contributing To Long Qt Syndrome, Anthony Owusu-Mensah, Jacqueline Treat, Joyce Bernardi, Ryan Pfeiffer, Robert Goodrow, Bright Tsevi, Victoria Lam, Michel Audette, Jonathan M. Cordeiro, Makarand Deo

Electrical & Computer Engineering Faculty Publications

We identified two different inherited mutations in KCNH2 gene, or human ether-a-go-go related gene (hERG), which are linked to Long QT Syndrome. The first mutation was in a 1-day-old infant, whereas the second was in a 14-year-old girl. The two KCNH2 mutations were transiently transfected into either human embryonic kidney (HEK) cells or human induced pluripotent stem-cell derived cardiomyocytes. We performed associated multiscale computer simulations to elucidate the arrhythmogenic potentials of the KCNH2 mutations. Genetic screening of the first and second index patients revealed a heterozygous missense mutation in KCNH2, resulting in an amino acid change (P632L) in the …