Engineering Commons^™

Effects Of Overcorrection On Mitigating Uncontrolled Tipping During Incisor Retraction Using Clear Aligners: Finite Element Analysis And In Vitro Experiment, Jianing Wang, Niko Burger, Bo Wang, Linxia Gu, Pengfei Dong

Biomedical Engineering Faculty Research and Publications

Uncontrolled tipping during incisor retraction with clear aligners continues to limit orthodontic treatment. Different countermeasures have been proposed to improve the predictability of aligners, such as power ridges and attachments, while their efficacy requires further investigation. This work investigated the biomechanics of the overcorrection in reducing the tipping angle and moment during incisor retraction with a clear aligner, through in vitro experiments and finite element analysis (FEA). Specifically, the influence of overcorrection angle (1 deg), retraction distance (0.15 mm), and the combination of both were assessed through in vitro experiments and the finite element simulation. Further computational simulations were conducted …

Analysis For Predicting Surface Temperature And Combustion Of Heavy-Duty, Pre-Chamber-Enabled, Hydrogen Engines, Tony Spezia

Master's Theses (2009 -)

Hydrogen as an alternative fuel shows great promise to help reduce greenhouse gas emissions from heavy duty engines. However, the challenge for hydrogen engines is that hydrogen has very different combustion properties compared to conventional hydrocarbon fuels. Hydrogen has very high flame speeds, very low ignition energy, and very wide flammability limit. These properties result in hydrogen engines being prone to abnormal combustion. Abnormal combustion makes hydrogen engines difficult to control or can cause catastrophic damage to the engine, so it is important to avoid conditions where abnormal combustion occurs. Hot spots along the combustion chamber walls are often the …

Edgecube -- An Iot Edge-Sensor Node For Tiny Machine Learning Applications, Nathan Gerard Timmins

Master's Theses (2009 -)

This thesis presents a novel internet-of-things (IoT) edge device, EdgeCube, a compact embedded system that combines a microcontroller unit (MCU) and a field-programmable gate array (FPGA). The proposed platform explores a trade-off between the performance gains achievable through FPGA-based acceleration and the associated increases in cost and power consumption. The primary contributions of this thesis include (1) the design of a compact hybrid MCU–FPGA edge architecture intended for vision workloads, (2) a streaming MCU-to-FPGA data path using SPI for frame transfer, and (3) an end-to-end hardware prototype and evaluation on an embedded inference task. Designed for IoT vision applications, EdgeCube …

X-Ray Tomography Of Damage Dynamics In Advanced Materials Using A Laser Wakefield Accelerator, Vigneshvar Senthilkumaran, Nicholas F. Beier, Sylvain Fourmaux, Peter Kenesei, Sean Dobson, Joël Maltais, Alvaro R. Arce-Borkent, Tait Richards, Michael G. Lipsett, Le Zhou, John A. Moore, Amina E. Hussein

Mechanical Engineering Faculty Research and Publications

Additively manufactured (AM) metals offer the potential for customizable, cost-effective components, but qualification and certification are crucial. Key to this process is understanding pore dynamics under stress, typically analyzed using micro-computed tomography. This study introduces laboratory-scale “betatron” x-rays from laser wakefield acceleration as a high-throughput alternative for x-ray tomography of advanced materials, such as AM AlSi10Mg alloys. Coupled with 3D finite element modeling, this method provides detailed insights into stress-porosity interactions. The approach delivers high-resolution scans, revealing that pore shape and local triaxiality significantly influence fracture dynamics, supporting advanced material characterization. This work also demonstrates the potential and versatility of …

How Do Social Network Models Compare To All-To-All Models For Forecasting Tuberculosis Epidemics? A Mathematical Modeling Study, Masabho Peter Milali, Hae-Young Kim, George Corliss, Anna Bershteyn

Electrical and Computer Engineering Faculty Research and Publications

Background. Mathematical models guide tuberculosis (TB) target-setting, yet most assume homogeneous “all-to-all” mixing. We compared projected intervention impacts between an all-to-all compartmental model and a Barabási–Albert (BA) scale‑free social network model under otherwise identical disease assumptions.

Methods. We calibrated transmission parameters so both models produced similar baseline trends, then introduced vaccination (coverage 30–70%; efficacy 80–95%) and treatment (20–50% increases in recovery) after a 400‑day burn‑in. Outcomes were assessed 300 days post‑intervention.

Results. Under 60% coverage, increasing vaccine efficacy from 80% to 95% yielded smaller projected reductions in active TB with the network model than with all‑to‑all mixing. Treatment improvements showed …

Evaluating Human Rod Photoreceptor Function Using Pixelwise Intensity-Based Optoretinography, Gao Yang, Mina Gaffney, Robert F. Cooper

Biomedical Engineering Faculty Research and Publications

Purpose: More than 50 inherited retinal diseases are known, with rod photoreceptor functional loss serving as an early indicator in nearly half of them. The “optoretinogram” is a relatively new assay that detects optical changes in cells in response to stimuli. This tool has excellent potential for providing insights into the earliest functional changes of rod photoreceptors, with the potential to assist in the early detection, monitoring, and treatment of retinal diseases.

Methods: In this work, we obtained intensity-based optoretinograms (iORGs) from rod photoreceptors using an adaptive optics scanning laser ophthalmoscope. We explore the necessity of both individual rod identification …

Severity And Duration-Dependent Aortic Stiffening In A Rabbit Coarctation Model Identifies Constitutive Material Parameters As Promising Regional Biomarkers For Hypertension Progression, Arash Ghorbannia, Jamasp Azarnoosh, John F. Ladisa Jr.

Biomedical Engineering Faculty Research and Publications

Coarctation of the aorta (CoA) alters hemodynamics and drives regional remodeling, yet the influence of severity and duration on constitutive properties is undefined. We quantified mechanical responses from CoA to identify constitutive parameters capturing stiffening across clinical severities and durations. Mild (≤ 12 mmHg), intermediate (13–20 mmHg), and severe (> 20 mmHg) CoA was created in rabbits for short, long, and prolonged durations (~ 1, 3, or 22 weeks, respectively). Stress–stretch curves from proximal and distal regions were fit with multiple constitutive models (Linear Elastic, Neo-Hookean, Yeoh, Ogden, Mooney–Rivlin, Holzapfel). Model performance was evaluated by normalized RMSE and R², with …

Development And Acceptability Of A Patient Decision Aid For People With Degenerative Cervical Myelopathy: An International Mixed-Methods Study, Andrew R. Gamble, David B. Anderson, Marnee J. Mckay, Benjamin M. Davies, Sophie Macpherson, James Van Gelder, Tammy Hoffmann, Kirsten Mccaffery, Samuel X. Stevens, Carlo Ammendolia, Rohil V. Chauhan, Carl M. Zipser, Timothy F. Boerger, Lindsay A. Tetreault, Michael G. Fehlings, Elanor Dustan, Carolyn Nugent, Helen Holmgren, Andreas K. Demetriades, Justin M. Lantz, Rana Dhillon, Chris G. Maher, Joshua R. Zadro

Biomedical Engineering Faculty Research and Publications

Objectives To develop and user-test a patient decision aid for people diagnosed with degenerative cervical myelopathy and who are considering surgery.

Design Mixed-methods study describing the development of a patient decision aid.

Setting A draft decision aid was developed by a multidisciplinary steering group (including study authors with degenerative cervical myelopathy, health professionals and researchers) informed by the best available evidence, authorship consensus and existing patient decision aids.

Participants Patient-participants and health professional-participants who manage people with degenerative cervical myelopathy were recruited through social media and the steering group’s research and practice network. Quantitative questionnaires were used to gather baseline …

Ƒ(Cell): Software For Reproducible Analysis Of Optoretinograms, Robert F. Cooper, Mina Gaffney, Brea D. Brennan, Niko Rios

Biomedical Engineering Faculty Research and Publications

Purpose: There has been a marked increase in use of a noninvasive functional imaging technique called optoretinography (ORG). As more groups use ORGs, it is crucial to have a consistent methodology, and understand what analysis parameters influence repeatability. In this work, we present an open-source software library called ƒ(Cell) designed to facilitate reproducible and repeatable analyses of ORG data.

Methods: We designed ƒ(Cell) as a Python software library that can co-register and analyze ORG datasets, while also enabling process auditing. To validate the software, we used our previously obtained normative optoretinography datasets as well as datasets from six …

Fixel-Based Analysis Of Pretreatment Mri Identifies White Matter Abnormalities In Pediatric Anti-Nmdar Encephalitis, Daniel Ackom, Janine Taitt-Tap, Scott A. Beardsley, Ricardo Vega, Alyssa Jobe, Andrew J. D. Crow, Brian Schmit, Lileth Mondok, Pradeep Javarayee

Biomedical Engineering Faculty Research and Publications

Anti-N-methyl-D-aspartate receptor (anti-NMDAR) encephalitis is an autoimmune disorder in which conventional MRI often appears normal, leading to clinical–radiologic dissociation and hindering early diagnosis and monitoring. We retrospectively studied five pediatric patients with anti-NMDAR encephalitis and compared their pretreatment diffusion MRI to age- and sex-matched controls. Using fixel-based analysis (FBA), we quantified tract-specific white matter abnormalities at the individual level. All patients showed significantly reduced fiber density and cross-section, with patterns ranging from focal to widespread involvement. In two patients, FBA abnormalities corresponded to seizure lateralization on EEG despite normal MRI, emphasizing FBA's added value in detecting seizure-concordant injury. One patient, …

Improving Interlimb Coordination And Paretic Limb Use After Stroke Using A Novel Robotic Split-Crank Pedaling Device: A Cross-Sectional Study, Tom S. Ruopp, Brian Schmit, Sheila Schindler-Ivens

Biomedical Engineering Faculty Research and Publications

Background. Many stroke survivors cannot walk effectively, even after rehabilitation. Causes include impaired muscle activation, poor interlimb coordination, and limited restorative interventions. To address this, we developed CUped (pronounced “cupid”), a motorized split-crank pedaling device designed to compel use of the paretic limb and retrain interlimb coordination. We examined its within-session effects, comparing three proportional control schemes—assist (A), resist (R), and assist plus resist (A + R)—to identify which best promotes recovery-related movement.

Methods. Nineteen individuals with stroke and eleven controls pedaled in 5-min bouts, one per control scheme. Each bout included pre-test, exposure, and post-test periods. Participants were instructed …

Separating The Control Of Moving And Holding In Human Post-Stroke Arm Paresis, Alkis M. Hadjiosif, Kahori Kita, Scott T. Albert, Robert A. Scheidt, Reza Shadmehr, John W. Krakauer

Biomedical Engineering Faculty Research and Publications

Moving and holding-still (holding) have been posited to be separately controlled. The paretic arm after stroke exhibits different abnormalities during rest vs. movement, providing an opportunity to ask whether control of these behaviors is independently affected in stroke. We quantified resting postural abnormalities in human stroke patients by measuring their biases in force production as they held their hand still in various locations in a planar workspace and then assessed whether these resting force biases influenced reaching in the same workspace. Patients displayed marked resting force biases at each location, even when the arm was supported. However, these …

Effective Transfer Of Tumor Annotations From Hematoxylin And Eosin To Fluorescence Images Of Breast And Lung Tissues, Tianling Niu, Emi Ampo, Julie M. Jorns, Mollie Patton, Tongtong Lu, Dong Hye Ye, Tina Yen, Bing Yu

Biomedical Engineering Faculty Research and Publications

Significance: Accurate transfer of annotations from histological images to fluorescence images is essential in developing deep learning (DL)-based optical imaging systems for intraoperative assessment of tumor margins. Manual annotation is time-consuming, prone to interobserver variability, and impractical for large-scale datasets.

Aim: We present a semi-automated method that can effectively transfer tumor annotations from pathologist-annotated hematoxylin and eosin (H&E) images to fluorescence images captured using microscopy with ultraviolet surface excitation (MUSE). This method is not intended for intraoperative use but rather to facilitate the creation of annotated datasets for DL model development.

Approach: Our semi-automated method consists of nonrigid image registration, …

Different Brain Network Connectomic Relationships Subserve Hand Dexterity During Task Versus Resting States In People With Brain Tumors, Timothy F. Boerger, Leon Taquet, Kaitlin Goetschel, Sarah Young, Jennifer Connelly, Jeffrey R. Binder, Brian Schmit, Max O. Krucoff

Biomedical Engineering Faculty Research and Publications

Purpose

The purpose of this study was to explore different brain network connectomic relationships subserving hand dexterity in patients with contrast-enhancing brain tumors during task and resting states.

Method

We measured hand dexterity, resting state functional connectivity, and task-based functional connectivity in 21 participants with newly diagnosed brain tumors. Hand dexterity was measured using the 9-hole peg test (9HPT), and patient-reported outcomes were assessed with the Duroz Hand Index (DHI).

Findings

We discovered the following: (1) The inability to complete dexterous tasks is most associated with low somatomotor-basal ganglia network connectivity during rest but high somatomotor-basal ganglia network connectivity during …

Patient-Informed Fluid-Structure Interaction Simulations Of Bicuspid Aortic Valve In Young Adults Reveal Regionalized Differences In Mechanical Stress, Hail B. Kazik, Harkamaljot S. Kandail, Joy Lincoln, John F. Ladisa

Biomedical Engineering Faculty Research and Publications

Bicuspid aortic valve (BAV) is a common congenital cardiovascular defect characterized by two, rather than three, cusps. Many BAV patients prematurely develop calcification and aortic stenosis by age 35, which is more severe with fusion of the right and noncoronary (RC/NC) cusps. The mechanisms underlying calcification observed within the coaptation, attachment, and fusion regions of BAV patients are unknown. While abnormal mechanical stimuli induced by the bicuspid anatomy likely plays a role, little is known about regionalized mechanical stimuli in these susceptible cusp regions of young patients prior to calcification. Strongly coupled fluid-structure interaction simulations were conducted using physiologic boundary …

Lung Injury Risk Curves From Behind Armor Blunt Trauma Using A Live Swine Model, Narayan Yoganandan, Lewis Somberg, Danielle Wilson, Alok Shah, Jared Michael Koser, Brian D. Stemper, Valeta Carol Chancey, Joseph Mcentire

Biomedical Engineering Faculty Research and Publications

Introduction

From structural, anatomical, and functional perspectives, components of the thoracoabdominal region are heterogeneous and physiologically and functionally different. Although their tolerances to injury are expected to be different, the current Roma Plastilina No. 1 clay penetration criterion for behind armor blunt trauma (BABT) is not specific to the body region. It is important to develop regional injury criteria to ensure its specificity. The objective of the study is to conduct impact tests on the lung region using a live animal model and develop injury risk curves using velocity and deflection metrics via parametric survival analysis.

Materials and Methods

Live …

Predictors Of Permanent And Temporary Motor Deficits In Patients Undergoing Glioma Resection: A Systematic Review And Meta-Analysis, Brian J. Conway, Stephanie A. Armstrong, Nada Botros, Sergey Tarima, Max O. Krucoff

Biomedical Engineering Faculty Research and Publications

Objective

To identify predictors of permanent and temporary motor deficits in patients undergoing glioma resection.

Methods

A literature search accessed the databases Ovid Medline, Scopus, Web of Science, Cumulative Index to Nursing and Allied Health Literature/EBSCO, PsychInfo, Cochrane, and Wiley for studies reporting motor outcomes following surgical resection of glioma. Outcomes were stratified by patient/tumor characteristics, preoperative condition, and intraoperative factors for both permanent and temporary motor deficits. Generalized estimating equations were used to generate odds ratios.

Results

A total of 1332 titles and abstracts were reviewed resulting in the evaluation of 261 full-text articles. Data were extracted from 67 …

Heat-Pipe-Based Thermal Management System Design For A 250-Kw Gan-Based Integrated Modular Motor Drive, Seyed Iman Hosseini Sabzevari, Salar Koushan, Armin Ebrahimian, Towhid Islam Chowdhury, Nathan Weise, Ayman El-Refaie

Electrical and Computer Engineering Faculty Research and Publications

Integrated modular motor drive (IMMD) is an effective approach for realizing high-efficiency, high-power-density, and fault-tolerant electric machines. However, designing an efficient thermal management system (TMS) for the motor drive becomes a challenge, particularly due to space constraints. This article presents the design of a TMS based on 3-mm heat pipes for a 250-kW IMMD intended for aviation applications. The power electronics module is simulated using PLECS software where an electrothermal analysis is conducted. A simplified thermal resistance model of the system is developed to estimate the die junction temperature of gallium nitride (GaN) semiconductors. The performance of the proposed TMS …

Axicons For Improved Resolution And Depth Of Focus In Adaptive Optics Scanning Light Ophthalmoscopy, Ruth E. Woehlke, Robert F. Cooper

Biomedical Engineering Faculty Research and Publications

Adaptive optics scanning light ophthalmoscopes are instrumental for studying the eye, yet they use truncated Gaussian illumination and are limited by diffraction, restricting resolution and depth of focus (DOF). Non-diffractive Bessel beams have emerged as an alternative. Here, we use two axicons configured as: (1) an extended DOF beam for resolving multiple retinal layers; and (2) an annular beam for increasing lateral resolution. We compare both approaches to truncated Gaussian illumination using a variety of metrics. Using Configuration 1, we successfully observed multiple retinal layers simultaneously. Using Configuration 2, we observed enhanced lateral resolution but decreased signal-to-noise ratio.

An Injectable, Dual-Curing Hydrogel For Controlled Bioactive Release In Regenerative Endodontics, Meisam Omidi, Daniela S. Masson-Meyers, Jeffrey M. Toth

Biomedical Engineering Faculty Research and Publications

Regenerative endodontics seeks to restore the vascularized pulp–dentin complex following conventional root canal therapy, yet reliable neovascularization within the constrained root canal remains a key challenge. This study investigates the development of an injectable, dual-curing hydrogel based on methacrylated decellularized amniotic membrane (dAM-MA) and compares its performance to a conventional gelatin methacryloyl (GelMA). The dAM-MA platform was designed for biphasic release, incorporating both free vascular endothelial growth factor (VEGF) for an initial burst and matrix-metalloproteinase-cleavable VEGF conjugates for sustained delivery. The dAM-MA hydrogel achieved shape-fidelity via thermal gelation at 37 °C and possessed tunable stiffness (0.5–7.8 kPa) after visible-light irradiation. …

Anisotropic Object-Based Shifts Of Attention Arise From Unequal Influences Of Visual Field Meridians On Neural Attention Gradients, David H. Hughes, Adam J. Barnas, Adam S. Greenberg

Biomedical Engineering Faculty Research and Publications

Object-based attention prioritizes the processing of information appearing within a selected object. We previously showed an object-based shift direction anisotropy (SDA) whereby horizontal shifts are more efficient than vertical shifts (Barnas AJ, Greenberg AS. Atten Percept Psychophys 78: 1985–1997, 2016; Barnas AJ, Greenberg AS. Vis Cogn 27: 768–791, 2019), an effect modulated by the visual field meridians (Barnas AJ, Greenberg AS. Q J Exp Psychol (Hove) 77: 2516–2532, 2024). Our present aim was to understand how the functional brain mechanisms of attention give rise to the SDA. We hypothesized that the SDA arises from attentional resources being partitioned differently by …

Applying Large Language Models For Surgical Case Length Prediction, Adhitya Ramamurthi, Bhabishya Neupane, Priya Deshpande, Ryan Hanson, Srujan Vegesna, Deborah Cray, Bradley H. Crotty, Melek Somai, Kellie R. Brown, Sachin S. Pawar, Bradley Taylor, Anai N. Kothari

Electrical and Computer Engineering Faculty Research and Publications

Importance Accurate prediction of surgical case duration is critical for operating room (OR) management, as inefficient scheduling can lead to reduced patient and surgeon satisfaction while incurring considerable financial costs.

Objective To evaluate the feasibility and accuracy of large language models (LLMs) in predicting surgical case length using unstructured clinical data compared to existing estimation methods.

Design, Setting, and Participants This was a retrospective study analyzing elective surgical cases performed between January 2017 and December 2023 at a single academic medical center and affiliated community hospital ORs. Analysis included 125493 eligible surgical cases, with 1950 used for LLM fine-tuning and …

Fundamental Exploration Of Soot Formation And Morphology From A Molecular Modeling Perspective, Khaled Mosharraf Mukut

Dissertations (1934 -)

Soot formation remains one of the least understood phenomena in combustion science, posing significant challenges due to its complex physicochemical nature and considerable environmental and health impacts. This dissertation presents a comprehensive molecular-level investigation into the fundamental mechanisms governing soot inception, particle growth, and morphological evolution through state-of-the-art reactive molecular dynamics (RMD) simulations of acetylene pyrolysis. A novel computational analysis utility, Molecular Arrangement and Fringe Identification and Analysis from Molecular Dynamics (MAFIA-MD), was developed to accurately characterize soot particle formation, providing detailed insights into chemical composition, internal structure, and surface characteristics. Critical physicochemical markers defining the boundary between gas-phase species …

Impactor Displacement As A Predictor Of Thoraco-Abdominal Organ Injury: Comparison Of Isolated Organ To Whole Body Tests, Jack Seifert, Jared Michael Koser, Alok Shah, Lance Frazer, Frank A. Pintar, Narayan Yoganandan, Dan Nicolella, Timothy B. Bentley, Brian D. Stemper

Biomedical Engineering Faculty Research and Publications

Purpose

Body armor is used to protect the wearer from penetrating injuries. However, when the armor defeats the projectile, it deforms at high rates into the wearer, referred to as back face deformation (BFD). This deformation can cause a variety of superficial and internal injuries and consequently should be considered when designing body armor. However, current design standards do not adequately consider the effects of BFD, and new data are necessary to inform future design thresholds for BFD. The objective of this study was to develop blunt impact injury risk curves for in vitro thoraco-abdominal organs and determine their applicability …

Elucidating The Impact Of Common Stormwater Pollutants On Antibiotic Resistance: The Role Of Heavy Metals, Nutrients, And Salts, Kassidy N. O'Malley, Patrick J. Mcnamara, Walter M. Mcdonald

Civil and Environmental Engineering Faculty Research and Publications

Antibiotic resistance poses a significant global health threat, and the urban water cycle presents an opportunity to augment or limit the spread of antibiotic resistance. In particular, stormwater runoff has recently been revealed as a key conduit for antibiotic-resistant bacteria (ARB). The specific role of stormwater pollutants, however, on antibiotic resistance has not been isolated. Understanding the impact of specific pollutants common to stormwater could help optimize design and operation of stormwater systems for management of antibiotic resistance. The objective of this research was to establish the potential contributions of common stormwater pollutants to antibiotic resistance proliferation. Lab-scale stormwater microcosms …

Novel Respirometry Measurement And Comparison Of Monod Kinetic Constants And Methanogen Concentrations For 27 Full-Scale Anaerobic Bioreactors, Nicholas Benn, Antonio Martins, Daniel H. Zitomer

Civil and Environmental Engineering Faculty Research and Publications

Monod kinetic coefficient values (km and Ks) as well as methanogen concentrations (Xac and Xh2) for various anaerobic bioreactors are required to gain a deeper understanding of anaerobic biotechnology. However, there are no existing, practical methods to measure or estimate these parameters or variables in typical anaerobic digester biomass that contains mixed cultures with inert organic solids. Current measurement methods rely on pure cultures developed in the laboratory. In this work, a novel respirometric method was developed and used to determine methanogen Monod parameters and active biomass concentration for samples from 27 full-scale anaerobic reactors. Differences (one to three orders …

Performance Enhancement In Rewound Industrial Retrofit Solutions For Five- And Six-Phase Permanent Magnet Assisted Synchronous Reluctance Machines, Kotb B. Tawfiq, Ayman M. El-Refaie, Peter Sergeant, Hatem Zeineldin, Ahmed Al-Durra, Ehab F. El-Sadaany

Electrical and Computer Engineering Faculty Research and Publications

This paper investigates upgrading aging three-phase Permanent Magnet Assisted Synchronous Reluctance Machines (PMaSynRMs) into multiphase configurations—specifically six- and five-phase windings—without modifying the existing stator or rotor laminations. This retrofit supports circular economic principles by extending machine life and reducing material waste and cost. Four configurations are examined: the original three-phase winding, asymmetrical six-phase winding, symmetrical six-phase winding, and five-phase winding. The feasibility of rewinding existing three-phase stators is explored for different slot/pole combinations. Balanced rewound five-phase windings are feasible only when the stator's slot/pole ratio is greater than or equal to 9. Both symmetrical and asymmetrical rewound six-phase windings are …

Advances In Noninvasive Imaging For Detecting Radiation-Induced Lung Injury (Rili), Austen Nissen, Said H. Audi, Anne V. Clough, Brian Fish, Amit Joshi, Meetha Medhora, Jason Walter Sidabras, Heather A. Himburg

Biomedical Engineering Faculty Research and Publications

Purpose: Dr. Richard Hill performed pioneering work in the field of radiation-induced normal tissue injury to the lung including noninvasive imaging studies aimed at identifying imaging biomarkers of radiation-induced lung injury (RILI). RILI is a life-threatening toxicity of radiation exposure relevant to both cancer patients undergoing thoracic radiation therapy (RT) and victims of accidental radiation exposure. The ability to detect RILI noninvasively has the potential to guide treatment planning for RT and, in the case of victims of acute radiation exposures, inform the decision to start mitigative therapies. As part of this special issue of IJRB honoring Dr. Hill’s many …

Designing A Portable And Accessible Diffuse Reflectance Spectroscopy System For Real-Time Detection Of Cervical Intraepithelial Neoplasia, Allison Scarbrough, Diana Moses, Tongtong Lu, Bing Yu

Biomedical Engineering Faculty Research and Publications

Significance: Over 80% of cervical cancer cases occur in lower-to-middle income countries (LMIC’s). This is partly because current screening techniques lack affordability, accessibility, and/or reliability for use in LMIC’s.

Aim: To develop an optical technique for cervical cancer screening that is affordable, accessible, and reliable for use in LMIC’s.

Approach: We developed a portable diffuse reflectance spectroscopy (DRS) system, which costs < $2500 USD to manufacture, and employs a Raspberry Pi to extract the absorption (μ_a) and reduced scattering (μ'_s) coefficients of biological tissue. The system was subject to travel and intentional rough handling. It was further used to capture 320 DRS spectra taken from 64 tissue-mimicking phantoms. Two …

Ac-Induced Corrosion Of Cathodically Protected Pipelines: Experimental Study And Probabilistic Modeling, Yuhan Su, Emadoddin Majdabadi Farahani, Qindan Huang, Qixin Zhou

Civil and Environmental Engineering Faculty Research and Publications

This study investigated the effects of alternating current (AC) interference on pipeline steel under cathodic protection (CP). In a simulated solution, real-time electrochemical measurements and corrosion rate analysis were conducted on two steel types (C1018 and X60) under various levels of AC interference with CP. Due to the complexity of AC-induced corrosion, relying on the shift in DC potential alone cannot accurately demonstrate the corrosion behavior in the presence of AC interference. In fact, such an approach may mislead the predictions of corrosion performance. It is observed that AC interference reduced the effectiveness of CP and increased the corrosion rate …