Engineering Commons^™

Engineering The Alveolar Gas Exchange Barrier With Extracellular Matrix Coatings For Bioengineered Lungs, Bethany M. Young

Theses and Dissertations

Lower respiratory diseases are currently the third leading cause of death worldwide. For many end-stage patients with these diseases, there is no cure and a shortage of donor organs available for transplant. A promising solution is to design regenerative scaffolds or complete bioengineered lungs, using decellularized lung tissues as a template for regeneration. Recent advances in the field have made significant strides towards developing a transplantable lung. However, the current technology has not produced a functional lung for in vivo transplant due to immature gas exchange barriers. The mechanisms driving alveolar barrier maturation and role that extracellular matrix (ECM) plays …

Eralpha Isoforms Modulate The Tumorigenicity Of 24r,25(Oh)2d3 In Estrogen-Responsive Cancer, Anjali Verma

Theses and Dissertations

Over 200,000 cases of breast cancer are diagnosed every year. Nearly 20% of these patients supplement their diets with some form of vitamin D. This high frequency of vitamin D supplement use may be due in part to research suggesting that cancer patients with higher serum vitamin D₃ levels have better prognoses than patients with low serum vitamin D_3. However, double-blind clinical trials on the efficacy of vitamin D₃ supplementation in breast cancer have been inconclusive. A recent meta-analysis showed evidence of reduced cancer recurrence in patients taking vitamin D₃ supplements who had ‘estrogen receptor positive’ …

Sensor Placement For Damage Localization In Sensor Networks, Fereshteh Firouzi

Theses and Dissertations

The objective of this thesis is to formulate and solve the sensor placement problem for damage localization in a sensor network. A Bayesian estimation problem is formulated with the time-of-flight (ToF) measurements. In this model, ToF of lamb waves, which are generated and received by piezoelectric sensors, is the total time for each wave to be transmitted, reflected by the target, and received by the sensor. The ToF of the scattered lamb wave has characteristic information about the target location. By using the measurement model and prior information, the target location is estimated in a centralized sensor network with a …

Mechanochemical Regulation Of Epithelial Tissue Remodeling: A Multiscale Computational Model Of The Epithelial-Mesenchymal Transition Program, Lewis Scott

Theses and Dissertations

Epithelial-mesenchymal transition (EMT) regulates the cellular processes of migration, growth, and proliferation - as well as the collective cellular process of tissue remodeling - in response to mechanical and chemical stimuli in the cellular microenvironment. Cells of the epithelium form cell-cell junctions with adjacent cells to function as a barrier between the body and its environment. By distributing localized stress throughout the tissue, this mechanical coupling between cells maintains tensional homeostasis in epithelial tissue structures and provides positional information for regulating cellular processes. Whereas in vitro and in vivo models fail to capture the complex interconnectedness of EMT-associated signaling networks, …

Energy Efficient Spintronic Device For Neuromorphic Computation, Md Ali Azam

Theses and Dissertations

Future computing will require significant development in new computing device paradigms. This is motivated by CMOS devices reaching their technological limits, the need for non-Von Neumann architectures as well as the energy constraints of wearable technologies and embedded processors. The first device proposal, an energy-efficient voltage-controlled domain wall device for implementing an artificial neuron and synapse is analyzed using micromagnetic modeling. By controlling the domain wall motion utilizing spin transfer or spin orbit torques in association with voltage generated strain control of perpendicular magnetic anisotropy in the presence of Dzyaloshinskii-Moriya interaction (DMI), different positions of the domain wall are realized …

Modeling The Peak Absorption Of Meh-Ppv In Various Solvents Using Density Functional Theory, Corell H. Moore

Theses and Dissertations

Density Functional Theory (DFT) and time-dependent Density Functional Theory (TD-DFT) are powerful tools for modeling orbital energy in conjugated molecules and have been useful tools for research in organic photovoltaics. In this work, DFT is first used to explain the red shift in the absorption spectrum and increased absorption observed in MEH-PPV. Initially, the modeling of the red-shift in the absorption peak of MEH-PPV is studied using Gaussian 03 software with the global hybrid functional B3LYP for exchange-correlation and the 6-31G basis set. DFT and TD-DFT are used to separately study the effects of polymer chain length, carbon-carbon double-bond stretching, …

Differential Mobility Classifiers In The Non-Ideal Assembly, Thamir Alsharifi

Theses and Dissertations

The differential mobility classifier (DMC) is one of the core components in electrical mobility particle sizers for sizing sub-micrometer particles. Designing the DMC requires knowledge of the geometrical and constructional imperfection (or tolerance). Studying the effects of geometrical imperfection on the performance of the DMC is necessary to provide manufacturing tolerance and it helps to predict the performance of geometrically imperfect classifiers, as well as providing a calibration curve for the DMC. This thesis was accomplished via studying the cylindrical classifier and the parallel plate classifier. The numerical model was built using the most recent versions of COMSOL Multiphysics^{® …}

Material Interactions And Self-Assembly In Inkjet Printing, Karam Nashwan Al-Milaji

Theses and Dissertations

Inkjet printing has attracted much attention in recent years as a versatile manufacturing tool, suitable for printing functional materials. This facile, low-cost printing technique with high throughput and accuracy is considered promising for a wide range of applications including but not limited to optical and electronic devices, sensors, solar cells, biochips, and displays. The performance of such functional devices is significantly influenced by the deposit morphology and printing resolution. Therefore, fabrication functional devices with precise footprints by inkjet printing requires deep understanding of ink properties, material interactions, and material self-assembly.

In conventional inkjet printing process, where sessile droplets are directly …

Cold X-Ray Effects On Satellite Solar Panels In Orbit, Myles Fogleman

Theses and Dissertations

An exo-atmospheric nuclear detonation releases up to 80 percent of its’ energy as X-rays. Satellite’s solar cells and their protective coatings are vulnerable to low energy X-ray radiation. Cold X-rays (~1-1.5 keV) are absorbed close to the surface of materials causing the blow-off and rapid formation of Warm Dense Plasmas (WDPs), particularly in a gap between the unshielded active elements of solar cells. To understand how WDPs are created, it is necessary to investigate the power density distribution produced by cold X-rays for typical solar panel surface materials. The Monte Carlo stepping model implemented in the GEANT4 software toolkit is …

Development Of An Eye Movement Based Predictive Model For Discrimination Of Parkinson's Disease From Other Parkinsonisms And Controls, Mary Anisa Kannan

Theses and Dissertations

Purpose: Due to the neurological aspects of Parkinson’s Disease (PD) and the sensitivity of eye movements to neurological issues, eye tracking has the potential to be an objective biomarker with higher accuracy in diagnosis than current clinical standards. Currently when PD is diagnosed clinically, there is an accuracy of 74% when diagnosed by a general practitioner and 82% when diagnosed by a movement disorder specialist. This study was designed to: 1. Assess eye movements as a potential biomarker for Parkinson’s Disease. 2. Determine if eye movements can distinguish between Parkinson’s Disease and commonly confounded movement disorders with parkinsonian symptoms. 3. …

Adhesion At Solid/Liquid Interfaces, Neda Ojaghlou

Theses and Dissertations

The adhesion at solid/liquid interface plays a fundamental role in diverse fields and helps explain the structure and physical properties of interfaces, at the atomic scale, for example in catalysis, crystal growth, lubrication, electrochemistry, colloidal system, and in many biological reactions. Unraveling the atomic structure at the solid/liquid interface is, therefore, one of the major challenges facing the surface science today to understand the physical processes in the phenomena such as surface coating, self-cleaning, and oil recovery applications. In this thesis, a variety of theory/computational methods in statistical physics and statistical mechanics are used to improve understanding of water adhesion …

Optimizing Nasal Cannulas For Infants Using Computational Fluid Dynamics, Ahmad El-Achwah Mr.

Theses and Dissertations

Aerosolized medications can potentially be delivered to the lungs of infants through a nasal cannula interface. However, nose-to-lung delivery technologies currently allow for ~1% of the loaded dose to reach an infant’s lungs. Conventional dry powder inhalers (DPI) are superior to other types of inhalers in many ways. However, passive DPIs that operate based on user inhalation and require large volumes of airflow are not applicable to infants. To overcome this challenge, positive pressure DPIs have been developed that enable aerosol delivery to infants. Unless an adequate nasal interface is used with these devices, a significant amount of drug will …

Assessment Of Access Methods For Mobile Maps For Individuals Who Are Blind Or Visually Impaired, David Parker

Theses and Dissertations

When people go to a mall, museums, or other such locations they tend to rely on maps to find their way around. However, for people who are blind or visually impaired (BVI) maps are not easily accessible and they depend on other means, such as a guide, to get around. Research has only just begun to investigate providing maps for people who are BVI on touch screen devices. Many different types of feedback have been used: audio (sound), tactile (touch), audio-tactile, and multitouch. Some research has been conducted on the benefit of using multiple fingers (multitouch) and has found conflicting …

Fabrication And Simulation Of Nanomagnetic Devices For Information Processing, Justine L. Drobitch

Theses and Dissertations

Nanomagnetic devices are highly energy efficient and non-volatile. Because of these two attributes, they are potential replacements to many currently used information processing technologies, and they have already been implemented in many different applications. This dissertation covers a study of nanomagnetic devices and their applications in various technologies for information processing – from simulating and analyzing the mechanisms behind the operation of the devices, to experimental investigations encompassing magnetic film growth for device components to nanomagnetic device fabrication and measurement of their performance.

Theoretical sections of this dissertation include simulation-based modeling of perpendicular magnetic anisotropy magnetic tunnel junctions (p-MTJ) and …

Electrochemical Separation Of Multivalent Species On A Liquid Bismuth Cathode In Licl-Kcl Eutectic For Used Nuclear Fuel Reprocessing, Michael Woods

Theses and Dissertations

The presence of group I/II fission products (Cs-137, Sr-90, and Ba-137) within molten salt nuclear processes degrades operational efficiencies by contributing to increased radiation levels in the case of material handling processes or to loss of criticality in the case of a reactor. While methods such as zone freezing and ion exchange have been proven for the separation of these fission products in LiCl-KCl salts, they require extra equipment and processing steps. Addition of a liquid metal electrode to molten salt media, such as the electrorefiner of a pyroprocessing scheme or the salt cleaning stage of a molten salt fast …

Modeling Electrospun Fibrous Materials, Sina Hassanpouryousefi

Theses and Dissertations

Electrospinning has been the focus of countless studies for the past decades for applications, including but not limited to, filtration, tissue engineering, and catalysis. Electrospinning is a one-step process for producing nano- and/or micro-fibrous materials with diameters ranging typically from 50 to 5000 nm. The simulation algorithm presented here is based on a novel mass-spring-damper (MSD) approach devised to incorporate the mechanical properties of the fibers in predicting the formation and morphology of the electrospun fibers as they travel from the needle toward the collector, and as they deposit on the substrate. This work is the first to develop a …

Engineering Of Earth-Abundant Electrochemical Catalysts, Dylan D. Rodene

Theses and Dissertations

Alternative energy research into hydrogen production via water electrolysis addresses environmental and sustainability concerns associated with fossil fuel use. Renewable-powered electrolyzers are foreseen to produce hydrogen if energy and cost requirements are achieved. Electrocatalysts reduce the energy requirements of operating electrolyzers by lowering the reaction kinetics at the electrodes. Platinum group metals (PGMs) tend to be utilized as electrocatalysts but are not readily available and are expensive. Ni_1-xMo_x alloys, as low-cost and earth-abundant transition metal nanoparticles (NPs), are emerging as promising electrocatalyst candidates to replace expensive PGM catalysts in alkaline media. Pure-phase cubic and hexagonal Ni_{1-x …}

An Evaluation Of The Information Security Awareness Of University Students, Alan Pike

Dissertations

Between January 2017 and March 2018, it is estimated that more than 1.9 billion personal and sensitive data records were compromised online. The average cost of a data breach in 2018 was reported to be in the region of US$3.62 million. These figures alone highlight the need for computer users to have a high level of information security awareness (ISA). This research was conducted to establish the ISA of students in a university. There were three aspects to this piece of research. The first was to review and analyse the security habits of students in terms of their own personal …

Sdn Testbed For Evaluation Of Large Exo-Atmospheric Emp Attacks, Diogo Oliveira, Nasir Ghani, Majeed M. Hayat, Jorge Crichigno, Elias Bou-Harb

Electrical and Computer Engineering Faculty Research and Publications

Large-scale nuclear electromagnetic pulse (EMP) attacks and natural disasters can cause extensive network failures across wide geographic regions. Although operational networks are designed to handle most single or dual faults, recent efforts have also focused on more capable multi-failure disaster recovery schemes. Concurrently, advances in software-defined networking (SDN) technologies have delivered highly-adaptable frameworks for implementing new and improved service provisioning and recovery paradigms in real-world settings. Hence this study leverages these new innovations to develop a robust disaster recovery (counter-EMP) framework for large backbone networks. Detailed findings from an experimental testbed study are also presented.

Microscale Direct Measurement Of Localized Photothermal Heating In Tissue-Mimetic Hydrogels, Benyamin Davaji, James E. Richie, Chung-Hoon Lee

Electrical and Computer Engineering Faculty Research and Publications

Photothermal hyperthermia is proven to be an effective diagnostic tool for cancer therapy. The efficacy of this method directly relies on understanding the localization of the photothermal effect in the targeted region. Realizing the safe and effective concentration of nano-particles and the irradiation intensity and time requires spatiotemporal temperature monitoring during and after laser irradiation. Due to uniformities of the nanoparticle distribution and the complexities of the microenvironment, a direct temperature measurement in micro-scale is crucial for achieving precise thermal dose control. In this study, a 50 nm thin film nickel resistive temperature sensor was fabricated on a 300 nm …

Predicting Cascading Failures In Power Grids Using Machine Learning Algorithms, Rezoan Ahmed Shuvro, Pankaz Das, Majeed M. Hayat, Mitun Talukder

Electrical and Computer Engineering Faculty Research and Publications

Although there has been notable progress in modeling cascading failures in power grids, few works included using machine learning algorithms. In this paper, cascading failures that lead to massive blackouts in power grids are predicted and classified into no, small, and large cascades using machine learning algorithms. Cascading-failure data is generated using a cascading failure simulator framework developed earlier. The data set includes the power grid operating parameters such as loading level, level of load shedding, the capacity of the failed lines, and the topological parameters such as edge betweenness centrality and the average shortest distance for numerous combinations of …

Uas Flight Operations In Complex Terrain: Assessing The Agricultural Impact From Hurricane Maria In The Central Mountainous Region Of Puerto Rico, Kevin Adkins

Publications

Hurricane Maria struck Puerto Rico in September 2017 as a Category 4 storm causing major damage to infrastructure, agriculture and natural ecosystems, as well as the loss of many lives. Among the crops hardest hit was coffee, one of the most important crops in Puerto Rico. As a perennial system, coffee takes various production forms along a gradient from high shade/biodiversity coffee farms to low shade coffee monocultures and therefore offers an ideal means for the study of resistance and resilience of an agroecosystem to weather and climate disturbance. During the summer of 2018, 14 impacted farms across the production …

Power System Loading Margin Enhancement By Optimal Statcom Integration:A Case Study, Sasidharan Shreedharan, Tibin Joseph, Sebin Joseph, Chittesh Veni Chandran, Vishnu J., Vipin Das P

Articles

Safe and secure network operation with acceptable voltage level has become a challenging task for utilities requiring corrective measures to be implemented. Network upgrades using Flexible Alternating Current Transmission System devices are being considered to serve this purpose. To this end, static loading margin enhancement by optimal static synchronous compensator (STATCOM) allocation to enhance the power transfer capability with minimal voltage variation is presented. Maximum loadability is formulated as an optimization problem, subjected to voltage and small-signal stability constraints. Stability indices are presented and incorporated with the optimization problem to ensure secure operation under maximum loading. The scheme is executed …

Efficient Spectral Compression Of Wavelength-Shifting Soliton And Its Application In Integratable All-Optical Quantization, Chao Mei, Jinhui Yuan, Feng Li, Binbin Yan, Xinzhu Sang, Qiang Wu, Xian Zhou, Kuiru Wang, Chongxiu Yu, Gerald Farrell

Articles

n this paper, we numerically demonstrate efficient spectral compression (SPC) of wavelength-shifting soliton in a chalcogenide strip waveguide. It is found that the profiles of group-velocity dispersion (GVD) and Kerr nonlinearity play key roles in determining SPC. After calculating the dispersion of Kerr nonlinearity and Raman spectrum for three kinds of chalcogenide materials, Ge11.5As24Se64.5 is chosen as the material for designing the chalcogenide strip waveguide (CSW). The geometric parameters of CSW are optimized to obtain the desired GVD and Kerr nonlinearity. Simulation results show that in the designed CSW, an input spectrum width of 52.04 nm can be compressed to …

Low Level Turbulence Detection For Airport, Derek Kearney, Anthony O'Connor

Articles

Low level wind shear and turbulence present a serious safety risk to aircraft during the approach, landing and take-off phases. Despite many advances in on-board and ground based warning systems. Wind shear remains a formidable force that coupled with a microburst can overpower any aircraft. Aviation reports have concluded that pilots need to have improved information in relation to tailwinds, wind shear and wind variations on approach and during the landing phases. Low level wind shear continues to cause disruption, delays and contribute to aircraft crashes. As recently as 2016, two Boeing aircraft crashed while attempting a Go-around manoeuver after …

Dc Side And Ac Side Cascaded Multilevel Inverter Topologies: A Comparative Study Due To Variation In Design Features, Shahab Sajedi, Michael Farrell, Malabika Basu

Articles

This paper presents a comparative study between DC side and AC side cascaded topologies for the hybrid modular multilevel converter (MMC) which are becoming popular in recent years. A multilevel converter with half or full bridge sub modules connected across DC link is another alternative for high-voltage applications as it has the same number of sub modules and footprint as AC side cascaded topology with the same DC link voltage and AC side voltage. The compared AC side cascaded structure offers a two-level converter as the high voltage stage and cascaded H-bridge (which is full bridge) sub modules with electrically …

Use Of Matrix-Pencil Method For Efficient Islanding Detection In Static Dg And A Parallel Comparison With Dwt Method, Sanjay Agrawal, Sandipan Patra, Soumya R. Mohanty, Vineeta Agarwal, Malabika Basu

Articles

Islanding or nonislanding events in grid-connected distributed generation bring along a typical distinguishable transient signature in its frequency profile. This demarcation leads to the development of a new islanding protection approach, which is based on the estimation of frequency waveform parameter (transient's frequency) by Matrix pencil (MP) method. To demonstrate the efficacy of the proposed MP method, four critical scenarios are considered in this paper for covering all possible disturbance events. These events are also compared along with a discrete wavelet transform (DWT) based islanding detection method in simulations as well as in RT-LAB-based real-time environment. It is noteworthy to …

Towards An Ontology For Soft Robots: What Is Soft?, Kevin Chubb, Damon Berry, Ted Burke

Articles

The advent of soft robotics represents a profound change in the forms robots will take in the future. However, this revolutionary change has already yielded such a diverse collection of robots that attempts at defining this group do not reflect many existing ‘soft’ robots. This paper aims to address this issue by scrutinising a number of descriptions of soft robots arising from a literature review with the intention of determining a coherent meaning for soft. We also present a classification of existing soft robots to initiate the development of a soft robotic ontology. Finally, discrepancies in prescribed ranges of Young’s …

Protection Of Sensitive Loads Using Sliding Mode Controlled Three-Phase Dvr With Adaptive Notch Filter, Samet Biricik, Hasan Komurcugil, Nguyen Duc Tuyen, Malabika Basu

Articles

This paper introduces a sliding mode control (SMC) strategy for three-phase dynamic voltage restorers (DVRs) with a 12-switch voltage source inverter. The compensating voltage references needed in the SMC strategy are generated by an adaptive notch filter (ANF), which exhibits excellent performance under grid voltage anomalies such as voltage sags, swells, and unbalanced and distorted grid voltage conditions. The consequence of using the ANF eliminates the use of phase-lock loop or frequency-lock loop and low-pass filter, which makes it distinguishable from the existing reference signal generation solutions. In addition, the use of the SMC strategy with its attractive properties makes …

Performance Of A Campus Photovoltaic Electric Vehicle Charging Station In A Temperate Climate, Ayda Esfandyari, Brian Norton, Michael Conlon, Sarah J. Mccormack

Articles

A photovoltaic (PV) array can be combined with battery energy storage to satisfy the electrical demand of lightweight electric vehicles. Measured solar resource and vehicle energy consumption, together with locational, mechanical and electrical constraints were used to design a vehicle charging station comprised of a 63 m2 10.5 kW AC PV array, with a 9.6 kWh lithium-ion battery. PV output, battery charge and discharge, electricity flows were monitored over one year. Deviations between measured and calculated annual AC generation averaged to 14%. Average annual direct consumption, self-consumption and system self-sufficiency were 8.47%, 30.3% and 74.36% respectively.