Engineering Commons^™

Reformulation Of The Protein Databank For Real-Time Search Of Geometrical Attributes Of Protein Structures, Musa Azeem, Christopher Lee, Aaron Hein, Christopher Ott, Homayoun Valafar

Faculty Publications

Introduction:

In this study, we introduce the design and implementation of PDBMine, a large-scale, queryable platform for mining sequence-structure statistics from the Protein Data Bank (PDB). PDBMine enables rapid analysis of local conformational trends across proteins by extracting dihedral angles and sequence patterns at scale. In addition to the design and implementation of PDBMine, we also present results validating its ability to return structurally meaningful information.

Methods:

We first assess the accuracy of its dihedral angle distributions by comparing them to established Ramachandran space and verifying expected behaviors of residues such as glycine and proline. We then use PDBMine to …

Insight Into The Decalcification Mechanism Of Calcium Silicate Hydrate Under A Water–Heat–Salt Environment, Wei Zhang, Boya Zhang, Jia Sun, Juntao Dang, Xiangke Guo, Keliang Li, Bo Tao Huang, Biqin Dong, Hongyan Ma, Dongshuai Hou

Civil, Architectural and Environmental Engineering Faculty Research & Creative Works

Understanding the decalcification mechanism of calcium silicate hydrate (C–S–H) under marine environments is crucial for concrete durability. In this study, the decalcification behavior of C–S–H under a water–heat–salt environment was systematically investigated through immersion experiments and reactive molecular dynamics simulations. Experimental results showed that elevated temperature and NaCl solution significantly accelerated Ca leaching and reduced the Ca/Si ratio of C–S–H. Simulation results further revealed that both high temperature and NaCl reduce the dissolution free energy of Ca, making its release more thermodynamically and kinetically favorable. Local structure analysis indicated that Cl^– disrupts Ca–Os (O atoms in silicate tetrahedra) connection …

Enhancing Wound Healing With Synergistic Dual-Drug Electrospun Roflumilast And L-Arginine Loaded Pla/Pva Nanofibers Through Fabrication, Optimization, And In Vivo Assessment, Samar A. Salim

Nanotechnology Research Centre

Current trends in improved wound management emphasize the development of dual-drug-loaded electrospun nanofibrous scaffolds. Herein, electrospun dual-drug loaded PLA/PVA nanofibrous scaffolds, incorporating roflumilast, a selective phosphodiesterase-4 inhibitor with anti-inflammatory activity, and L-arginine, a precursor to nitric oxide with stimulating activity towards wound healing and tissue regeneration, were developed. A dual-spinneret electrospinning process enabled the coloading of drugs in PLA and PVA phases. Scaffolds were characterized by SEM, FTIR, and XRD, showing consistent fiber morphology, and amorphous drug formation. FTIR analysis was performed to confirm drug–polymer compatibility and successful incorporation of roflumilast and L-arginine within the PLA/ PVA nanofibrous matrix. Swelling …

An Optimized Hybrid Xgboost-Lstm-Gru Model For Energy Consumption Forecasting In Smart Homes Using Weather Data, Marwah J. Salman, Eman M. El-Gendy, Amira Y. Haikal, Mahmoud M. Saafan

Mansoura Engineering Journal

Energy consumption is increasing every day due to the proliferation of smart homes and smart household appliances, which deplete existing energy resources. Therefore, efficient energy management by accurately predicting energy consumption is critical. In this paper, a hybrid prediction model is proposed to forecast energy consumption in smart homes using weather data. The proposed system follows five steps: data acquisition, data preprocessing, feature selection, prediction, and hyperparameter optimization. In the data acquisition step, all attributes except the weather attributes are removed. The min-max algorithm is then applied to normalize the dataset to a specific scale, preventing the prediction model from …

Capturing Sclera Anisotropy Using Direct Collagen Fiber Models: Linking Microstructure To Macroscopic Mechanical Properties, Fengting Ji, Xuehuan He, Frederick Sebastian, Mohammad R. Islam, Hannah Schilpp, Bingrui Wang, Yi Hua, Rouzbeh Amini, Ian A. Sigal

Mechanical Engineering Faculty Publications

Collagen fibers are essential to the mechanical behavior of soft tissues, including sclera. Conventional models often represent these fibers statistically, potentially missing crucial aspects of their role in tissue behavior. In this study, we expand on a direct fiber modeling approach that we recently presented based on explicitly representing the sclera long, interwoven fiber bundles. Specifically, our goal was to capture specimen-specific 3D fiber architecture and anisotropic mechanics of four ovine sclera samples (superior from Eye-1, temporal and superior from Eye-2, and temporal from Eye-3), each tested under five conditions: equi-biaxial (1:1) and four non-equi-biaxial (1:0.75, 0.75:1, 1:0.5, and 0.5:1). …

General And Special Relativity May Explain The Hubble Tension And Galactic Rotation, Charles F. Babbs

Weldon School of Biomedical Engineering Faculty Working Papers

Using two equations from general and special relativity, one can explore the hypothesis that gravitational time dilation and the relativistic Doppler effect cause the Hubble tension. Predicted results show good agreement between theory and observation, as long as mass is restricted to ordinary baryonic matter. This unexpected finding suggested a surprising continuation, namely that observed galactic rotation also be explained by special relativity. This idea survived initial tests using both Vera Rubin’s original data and more recent observations.

Jiving With Llms: Assessing First Year Students’ Computer Programming Self Efficacy After Reading Code With Llms, Michelle Jarvie-Eggart, Joseph Roy Teahen, Daniel T. Masker, Jose Padilla, Leo C. Ureel Ii, Laura E. Brown, Scott Pomerville, Jon Sticken

Michigan Tech Publications

This study investigated the impact of leveraging generative artificial intelligence (GenAI) to assist 1st-year engineering and computer science (CS) students in reading code in a new (to them) language. Students were asked to comment code in FORTRAN. They were then asked to run the code through ChatGPT-4.0 for its comments and reflect on what they learned from the experience. Participants completed survey items from Ramalingam and Wiedenbeck’s Computer Programming Self-Efficacy Scale (CPSES) prior to and after the intervention. Additional open-ended reflective (qualitative) questions were added to the quantitative questions in the postintervention questionnaire. This study documents increases in self-efficacy for …

Atmospheric Waves Experiment (Awe) Thermal Control System: Review Of On-Orbit Performance, Matthew I. Ralphs, Mike Holt

Space Dynamics Laboratory Publications

This paper reviews the Atmospheric Waves Experiment (AWE) detector thermal control system’s (TCS) performance for over two years of operation on the Internation Space Station (ISS). The TCS employs active thermal control for the InGaAs detectors with thermoelectric coolers (TEC). Each of the four detectors are controlled by a dedicated TEC at a nominal setpoint of -30°C, with heat transported away via low-mass, high-conductance pyrolytic graphite sheet (PGS) thermal straps into a nickel-plated copper conductor bar. A bi-directional radiator with Silver Teflon ensures an unobstructed view that can radiate the heat away to space. Titanium isolators decouple the detectors from …

A Suite Of Thermal Switches For Surviving Extreme Thermal Environments In Space, Matthew I. Ralphs, Matt Jensen, Alexis Eames, Matt Sinfield

Space Dynamics Laboratory Publications

Thermal switches are a key enabling technology for spacecraft operating in extreme thermal environments. Whether surviving the lunar night, managing intermittent high-power loads from deep space communication systems, or dealing with other extreme thermal environments, high-performance thermal switches allow critical missions to operate beyond conventional thermal design limits. This paper presents the development, testing, and performance of a suite of passive thermal switches designed for both spacecraft- and subsystem-level thermal control. The suite includes: (1) traditional in-line switch placed between sensitive components and radiators; (2) compact designs suitable for integration into standard bolted joint interfaces to modulate the conductance between …

Hypersonic Non-Equilibrium Cfd And Dsmc Model Comparisons With The Varda Reentry Capsule, Jack D. Crespo, Paolo Valentini, Ashwin P. Rao, Zach S. Davis

Space Dynamics Laboratory Publications

Nonequilibrium aerothermodynamic modeling of the Varda hypersonic testbed capsule is conducted with direct simulation Monte Carlo (DSMC) and computational fluid dynamics (CFD) solvers. Flowfield properties at the 78 km reentry trajectory point are extracted to compute line of sight spectral radiance using two radiative emission codes, namely HARA and NEQAIR. Computed spectra are compared to spectral radiance measured by an in situ optical emission spectroscopy payload flown on Varda’s W-2 capsule in 2025. Model comparisons to the experimental data reveal discrepancies between the HARA and NEQAIR radiative emission predictions in both overall magnitude and qualitative behavior. NEQAIR was found to …

An Investigation Of A Mach 15 Flow Over A Blunt Wedge Using First-Principles Potential Energy Surfaces: Influence Of Wall Temperature, Paolo Valentini, Zach Davis, Maninder S. Grover, Nicholas J. Bisek

Space Dynamics Laboratory Publications

The simulation of a Mach 15 air flow over a blunt wedge is conducted using the direct molecular simulation (DMS) method. Due to partial dissociation of the air mixture at the imposed free stream conditions, the shock layer contains N₂, O₂, NO, N, and O. All potential energy surfaces (PESs) used to model the various molecular interactions only describe electronic ground states energetics. Thus, no electronic excitation is modeled. An isothermal wall boundary condition is imposed, with full momentum and energy accommodation. Two wall temperatures are considered in this work, namely 1,000 K and 2,000 K. …

Rheology-Guided Spinnability In Emulsion Forcespinning Of Water-In-Oil Nanofibers: Influence Of Surfactants And Internal Phase Concentration, Saptasree Bose, Alexandra Salinas, Evelyn Torres, Jose Ramirez, Elizabeth Gamez, Michelle A. Calabrese, Karen Lozano, Victoria Padilla

Mechanical Engineering Faculty Publications

This study explores the emulsion Forcespinning (FS) approach for fabricating nanofibers with a hydrophilic phase encapsulated within a hydrophobic polymer matrix. Key factors influencing fiber production and morphology, including the concentration of the internal water phase and the presence of ionic and nonionic surfactants, were systematically investigated. Additionally, the centrifugal spinnability of the emulsions was assessed using environmentally controlled dripping-onto-substrate (DoS) rheometry, correlating the observed extensional flow behavior and emulsion extensibility with fiber spinnability. The nanofibers were characterized by scanning electron microscopy (SEM), thermogravimetric analysis (TGA), differential scanning calorimetry (DSC), and Fourier transform infrared (FTIR) spectroscopy. These findings offer critical …

Temperature Dependent High Frequency Performance Of A 62% Algan Channel Hemt, Jiahao Chen, Abdullah Al Mamun Mazumder, Parthasarathy Seshadri, Dheekshinn Nandakumar, Ruixin Bai, Rafael Andrew Choudhury, M. Asif Khan, Chirag Gupta

Faculty Publications

This article reports on the temperature dependent performance of a HEMT with an Al_0.62Ga_0.38N channel layer and an Al_0.84Ga_0.16N barrier layer grown by metal–organic chemical vapor deposition. The device in this report was measured at room temperature and elevated temperatures of 100–150 °C. The sheet resistance increased from 3.5 kΩ/sq (25 °C) to 5.4 kΩ/sq (150 °C), while the contact resistance remained nominally similar. For a device with 160 nm gate length and 2 µm source-to-drain length, excellent electrical characteristics have been achieved when the device was operated at 150 °C with …

Novel Repurposing Of Empagliflozin-Loaded Buccal Composite (Chitosan/Silk Fibroin/Poly(Lactic Acid)) Nanofibers For Alzheimer’S Disease Management Via Modulation Of Aβ–Ager–P-Tau Pathway, Samar A. Salim

Nanotechnology Research Centre

Background/Objectives: Empagliflozin (EMPA) was repurposed for Alzheimer’s disease (AD) treatment via buccal delivery, exploiting novel nanofibers (NFs) integrating chitosan (Cs), silk fibroin (Fb), and poly(lactic acid) (PLA). Methods: EMPA-loaded Cs/Fb/PLA NFs were electrospun in different formulations to optimize the formulation parameters. The optimized formulation was then investigated for its enhanced in vivo effect. Results: Optimized nanofiber diameters ranged from 459 ± 173 to 668 ± 148 nm, possessing bead-free morphology confirmed by SEM and satisfactory mechanical properties. EMPA was successfully well-dispersed in the polymer matrix as evidenced by FTIR, XRD, and drug content. The optimized NFs displayed a hydrophilic surface …

Combinatorial Synthesis Of Protein-Polymer Conjugates By Post-Polymerization Modification Of Poly(Pentafluorophenyl Acrylate)S, Emily W. Kish, Thatcher M. Lee, Alexis M. Ziemba, Ama Boamah, Bianca Figueroa, Margherita Piccardi, Carey E. Dougan, Sarah J. Moore, Maren E. Buck

Chemistry: Faculty Publications

Combinatorial methods for preparing polymeric biomaterials enable the rapid identification of materials useful for many applications in science, medicine, and engineering. In the work described here, we demonstrate that side-chain reactive polymers can be used as templates for the rapid preparation of a small library of diversely functionalized protein–polymer conjugates. The activated ester polymer poly(pentafluorophenyl acrylate) (PPFPA) was modified postpolymerization with substoichiometric equivalents of three hydrophilic primary amines to yield a library of amphiphilic, side-chain reactive copolymers. These copolymers were then conjugated to two receptor-targeting proteins, holotransferrin (hTF) and an engineered fibronectin-based protein (Fn3), through amine-activated ester coupling. We investigated …

Simulation Results Of Spaceborne Ssa Using A Comprehensive Passive Radar Model, Chinmay Gaikwad, Filipe Senra, Thomas Alan Lovell, Hao Peng, Berker Pekoz, Tianyu Yang

Publications

In this paper, a high-fidelity simulation framework is developed to assess the feasibility of tracking space debris using a large low-Earth orbit (LEO) satellite constellation equipped with onboard passive radar sensors. By exploiting illumination from a distributed network of ground-based transmitters, the constellation provides consistent line-of-sight access to debris objects at higher altitudes, enabling angles-only detection and tracking. This approach yields a scalable, automated, and cost-effective architecture for next-generation space surveillance and contributes to more resilient space traffic management. A complete angles-only passive-radar orbit-determination pipeline is introduced and demonstrated. Initial orbital states are generated using a rate-aware constrained admissible-region multiple-hypothesis …

Optimized Resnet-18 Architecture For Multi-Class Oral Diseases Classification, Ahmed Ahmed

Karbala International Journal of Modern Science

In recent years, the classification of oral diseases has gained significant attention due to its influence on public health and the necessity for early and accurate diagnosis. Traditional diagnosis depends on manual clinical assessment, which can be slow and subjective. An optimized and subsequently quantized model is required to provide a faster and more consistent diagnostic support tool. This paper proposes an optimized ResNet-18 architecture for the classification of six oral diseases. The optimization process is based on removing the Rectified Linear Unit (ReLU), Batch Normalization (BN), and convolutional layers from the base ResNet-18 blocks that contain 128 filters. This …

Cs Tools - Stormwater Management Software (Version 6.5.0), Donald V. Chase

Drainage Design Tools

The CS Tools program is an outgrowth of research conducted by the University of Dayton for CON/SPAN Bridge Systems.

Preliminary Evaluation Of Remote Sensing Evapotranspiration Models For Field-Scale Agricultural Water Management In Arid Central Iran, Somayeh Sima, Iman Raissi Dehkordi, Mohammadhosein Taghikhani, Neamat Karimi

Civil and Environmental Engineering Faculty Publications

Accurate estimation of actual evapotranspiration (ET_a) is crucial for effective water resource management and optimizing agricultural yields. While satellite-based surface energy balance ET_a models are widely adopted, their field-scale accuracy in under-researched regions, such as Iran, remains a critical knowledge gap. This study assesses five prominent models—PySEBAL, PyMETRIC, SSEBop, PyTSEB, and ETLook (from FAO’s WaPOR v.2, L1 product)—for daily ET_a estimation over an alfalfa field in the arid central part of Iran. Models were adjusted for the field using in situ weather data and Landsat-8 images, and validated against the scintillometer data. Results showed SSEBop provided …

Large-Scale Cubesat Chassis, Matthew D. Evans, Robert A. Bettinger

AFIT Patents

The present invention relates to large-scale CubeSat chassis and methods of making and using same. The disclosed CubeSat comprises specific structural features that can yield up to at least a 27 U CubeSat that has comparable or even better performance and benefits than that of smaller CubeSats. Such volume increase coupled with the structural integrity of Applicants' CubeSats opens up a wide range of CubeSat performance increases including, but not limited to, larger payloads, more diverse payloads and larger CubeSat fuel capacities. Such increased payload capabilities includes, for example, increased focal length capabilities and such improved maneuverability results in, for …

Optimal Placement Of Electric Vehicle Chargers: A Mixed-Integer Linear Programming Model, Joubin Zahiri Khameneh, Emmanuel Fagbenle

Faculty Publications

Electric vehicle adoption is growing, but New Hampshire lags in public charging infrastructure, especially in rural areas. This gap increases range anxiety and economic inefficiencies. In this study, we developed a mixed-integer linear programming (MILP) model to optimally locate new electric vehicle chargers statewide, maximizing coverage and equity under budget constraints. The model includes geographic coverage requirements, population-weighted equity, capacity limits, and a $28 million budget. Moreover, the model recommends 855 Level 2 chargers and 149 Direct Current Fast Chargers (DCFCs) across 247 ZIP Codes, nearly doubling public charging capacity and achieving 98.8% coverage within defined service radii. The plan …

Merging Terrestrial And Satellite Gravity Data For Africa: A Possibility To Fill-In The Data Gaps, Hussein A. Abd-Elmotaal, Norbert Kuhtreiber

Mansoura Engineering Journal

The major challenge that the IAG Sub-Commission on gravity and geoid in Africa faces is the significantly large gravity data gaps. It is essential to properly tackle this issue for all geodetic applications in Africa due to the large interpolation errors occur at these large gaps. Simple interpolation (using any type of interpolation technique) of the gravity data does not add new information at the large data gaps, and the solution is free there. Global Earth gravity models offer themselves as a possible way to fill-in such large data gaps, provided that they approximate the African gravity field to an …

Model-Based Investigation Of The Influence Of Environmental Conditions On The Energy Supply Of Multirotor Uavs, Morten Roßberg, Hanna Dibbern, Claudia Werner

Journal of Aviation Technology and Engineering

Flight time of unmanned aerial vehicles (UAVs) is limited by available energy, which is affected by the mission profile and external factors, such as environmental conditions. Two main environmental conditions that need to be considered are the impact of wind and ambient temperature on the UAV and its energy supply. The purpose of this study is to examine the effects of wind and ambient temperature to conduct a preliminary evaluation of flight performance and flight limitations. For this reason, three locations in the United States—New York City, Miami, and Fairbanks—are selected and the impact of the considered environmental conditions of …

A Contextual Attention-Based Transformer Model For Enhanced Hate Speech Detection On Twitter, Mira Mansour, Nancy Akoum, Seifedine Kadry

Iraqi Journal for Computer Science and Mathematics

Hate speech on social media poses significant societal challenges, necessitating accurate and context-sensitive automated detection. Traditional machine learning (ML) models typically rely on lexical or superficial features, limiting their ability to capture nuanced or contextually ambiguous expressions of hate speech. Recent transformer-based methods (e.g., RoBERTa) provide improved contextual understanding but often lack explicit mechanisms guiding the model’s attention to critical semantic tokens, thereby reducing interpretability and sensitivity to nuanced linguistic contexts. This paper introduces a novel contextual attention-guided transformer model that explicitly incorporates lexicon-guided attention supervision into RoBERTa fine-tuning, significantly enhancing semantic precision in hate speech detection on Twitter. Evaluations …

Research Progress On Generating Perfect Vortex Beams Based On Metasurfaces, Xiujuan Liu, Manna Gu, Ying Tian, Mingfeng Zheng, Bo Fang, Zhi Hong, Chee Leong Tan, Xufeng Jing

Electrical and Computer Engineering Faculty Publications and Presentations

This article reviews the latest advances in the generation and control of perfect vector beams using metasurfaces. In recent years, metasurfaces have garnered increasing interest due to their simple fabrication and easy integration. Perfect vortex beams (PVBs), as a type of vector beams, exhibit complex polarization states that require the superposition of multiple phases for their generation. The use of metasurfaces provides a compact platform for the generation of perfect vortex beams and enables more complex vortex beam control tasks, which are quite challenging for traditional optics. This paper begins by introducing the principle of perfect vortex beam generation using …

Finite Element Analysis Of Tire–Pavement Interaction Effects On Noise Reduction In Porous Asphalt Pavements, Miao Yu, Geyun Lv, Anqi Li, Jing Yang, Zhexi Zhang, Dongzhao Jin, Rong Zhang, Jiqing Li

Michigan Tech Publications

This study investigated the noise reduction performance of porous asphalt concrete (PAC) pavement under tire–pavement coupling conditions, addressing the limitations of field measurements and laboratory testing. First, tire excitation amplitude parameters were determined based on vibrational contact operational scenarios. Then, finite element simulations were conducted to systematically analyzing the tire–pavement coupling noise characteristics of PAC pavement. The results indicate that PAC pavement effectively reduces the air pumping noise due to its highly porous internal structure, leading to significant noise attenuation. Furthermore, the study examined the key factors influencing the tire–pavement coupling noise in PAC pavement. When maintaining constant vehicle parameters …

Numerical Solution Of A Coupled Nonlinear Dynamic Problem Of Thermoviscoelasticity, Abdali Abdukarimov, Ibodat Turabekovna Khaldybaeva, Askarova Shamshetdinovna Ayjamal

Technical science and innovation

This paper presents a numerical solution of a coupled nonlinear dynamic problem of thermoviscoelasticity. A Duffing-type oscillator with temperature-dependent properties is used to model nonlinear hereditary deformable systems. After specifying the temperature dependences of the elastic modulus 𝐸 and viscosity parameter 𝜂 and introducing dimensionless variables, the problem is reduced to a system of nonlinear integro-differential equations. A numerical procedure for solving this system is developed, and representative examples are computed. The results are presented in graphical form for various values of the governing parameters.

Blockchain-Based Peer-To-Peer Renewable Energy Trading And Traceability Of Transmission And Distribution Losses, Amit Kumar Vishwakarma, Pratyush Kumar Patro, Adolf Acquaye, Raja Jayaraman, Khaled Salah

Industrial Engineering: Faculty & Staff Publications

In attempts to progress the transition towards decarbonizing energy systems and achieving sustainable development goals linked to energy, renewable energy sources (RES), which are decentrally deployed, are being widely promoted. However, RES are constrained by many barriers, some of which are technical in nature, such as energy losses. For instance, traditional peer-to-peer (P2P) trading systems have been used as a mechanism to advance RES because they offer a promising solution for decentralized energy trading without third-party intermediaries. However, it faces significant challenges, notably in accounting for energy losses during transmission and distribution, thus reducing overall system efficiency. We propose an …

Precision Acoustofluidics For High-Throughput Mechanobiology In Suspension Cells, Kaichun Yang, Ruoyu Zhong, Ke Li, John Mai, Pengzhan Liu, Ye He, Joseph Rich, Ying Chen, Janna Wang, Zhiteng Ma, Zhiteng Ma, Xianchen Xu, Qian Wu, Tony Jun Huang

Faculty Publications

Mechanomodulation, the process of altering cellular behavior through applied mechanical forces, plays a critical role in physiological processes and has substantial implications for cancer therapy, immunology, and drug development. However, precise and efficient stimulation of nonadherent cells remains a major challenge, limiting the investigation of mechanotransduction pathways and the development of targeted therapeutics. Here, we developed an acoustofluidic platform named Suspension-cell Targeted Response to Excitation via Acoustofluidic Mechanomodulation (STREAM) to enable precise, high-throughput stimulation of suspension cells. STREAM accomplishes this using 101.14-megahertz high-frequency surface acoustic waves to deliver controlled mechanical stimulation at a throughput of 500,000 cells per minute. STREAM …

Pengujian High Fidelity Prototipe Media Pembelajaran Interaktif Bahasa Inggris Dengan Gamifikasi Menggunakan User Experience Questionare, Adhitya Prastyadi, Meizano Muhammad Ardhi, Daniel Rinaldi, Margaretha Karolina Sagala

Jurnal Sosial Humaniora Terapan

Abstract

Testing a Hi-Fi Prototype of Interactive English Learning Media with Gamification Using UEQ

This study aims to test and evaluate the User Experience (UX) quality of a High-Fidelity prototype for interactive English learning media integrating gamification elements. The research is motivated by the low English proficiency and motivation among Indonesian students, and the potential of digital media and gamification to enhance learning engagement. Inspired by the success of the Duolingo application, this prototype was designed to create an enjoyable and effective learning experience. A quantitative research methodology was employed, involving high school students as participants selected via purposive sampling. …