Engineering Commons^™

Nonlinear Optical Microscopy Assessment Of Tissue Structure And Chondrocyte Viability Of Articular Cartilage, Michael Le

All Theses

Articular cartilage functions to protect the ends of bones by providing a surface that can withstand compressive forces and minimize friction during movement. Collagen fibers form the organizational backbone of the extracellular matrix (ECM) in cartilage. Proteoglycans within the ECM function to retain water and provide the tissue with the swelling pressure needed to withstand compressional forces. Chondrocytes, the only type of cell found in articular cartilage, produces these collagen fibers and proteoglycans to maintain the tissue structure and function. Significant injuries to articular cartilage can damage the chondrocytes and disrupt their ability to maintain homeostasis in the tissue. Therefore, …

Atomic Force Microscopy Based Dna Sensing And Manipulation, Matthew Shubert

Mechanical Engineering Undergraduate Honors Theses

Sequencing DNA provides a positive impact for the biomedical community by understanding a wide variety of applications such as human genetics, disease, and pathogens. The reason the Arkansas Micro & Nano Systems lab is involved with research in DNA sequencing is due to the current, leading industry method. Nanopore sequencing was developed by Oxford Nanopore Technology in which its sequencing method separates double stranded DNA to electrically characterize individual nucleotides traveling through a charged nanopore. Unfortunately, nanopore sequencing uses biological materials that require a shelf life and drives high cost. Therefore, the Arkansas Micro & Nano Systems lab has developed …

Pulse Rate Variability Analysis During Hemorrhage In An Experimental Porcine Model, Gabbie Bonvillain, Lauren Crimmins, Md Abul Hayat, Adria Abella Villafranca, Sam Stephens, Hanna K. Jensen, Joseph A. Sanford, Jingxian Wu, Kevin W. Sexton, Morten Jensen

Biomedical Engineering Undergraduate Honors Theses

During the acute phase of hemorrhage, heart rate and peripheral resistance increases to maintain proper oxygen delivery to vital organs. This response is mediated by the autonomic nervous system. Heart rate variability (HRV) has become a widely utilized measure to determine the autonomic nervous system control over the heart. Recently, pulse rate variability (PRV) has been suggested to serve as a surrogate for HRV. This study evaluates the ability of PRV obtained from peripheral arterial pressure waveforms as a method for detecting hemorrhage. Time domain and frequency domain metrics were evaluated for 5-minute and 15-minute arterial pressure waveform signals prior …

Localized Intra-Arterial Drug Delivery Device For Stroke Treatment, Benjamin Yip

Biomedical Engineering Undergraduate Honors Theses

Strokes are one of the leading causes of death and long-term disability in the United States, and according to the Centers for Disease Control and Prevention more than 795,000 people experience a stroke every year. Around 87% of all strokes are ischemic strokes making it the most common form of stroke. While ischemic strokes are treatable, current devices and methods still result in high mortality rates and high risks of hemorrhaging after treatment. The aim of this study is to design and test a prototype of a novel device for the localized delivery of thrombolytics to treat ischemic strokes. The …

Simulation Of Li Dendrite Inhibition In Lithium Battery By Phase-Field Method, Yao Ren

Material Science and Engineering Dissertations - Archive

Lithium (Li) dendrite growth poses serious challenges for the development of Li metal batteries which also stops the footsteps of human utilizing the environment-friendly new power source. Replacing liquid electrolyte with solid electrolyte can not only inhibit the dendrite growth by mechanical suppression, but also introduce more possibilities to the electrochemistry of battery. However, the underlying mechanism is still not fully understood, and most theoretical works focus on pure liquid electrolyte, ignoring the mechanical strain effects. Here we developed a phase-field model which simulates the Li dendrite growth to study the competition between diffusion and deposition rates, the pure elastic …

Nonviral Approaches For Delivery Of Crispr-Cas9 Into Hepatocytes For Treatment Of Inherited Metabolic Disease, Tanner R. Rathbone

All Dissertations

Inherited metabolic diseases (IMDs) of the liver have a collective occurrence of about 1 in 800 births. Current therapies for IMDs of the liver are limited, and the only curative option for patients is orthotopic liver transplantation. Due to shortages of organ donors, immunosuppression following the transplantation, and mortality risks associated with the procedure, alternative treatment options are necessary for curing IMDs of the liver. Therapeutic gene editing has been proposed as a potential strategy for treating IMDs of the liver. Adeno-associated viral vectors (AAVs) are the most widely used delivery method for liver-targeted gene therapies. Although widely used for …

Integrating Fire Responses To Combat Wildfires, Jonathan Leonard Badal

Electrical Engineering

Each year wildfires cause significant loss of property, worsen people’s health, and destroy multiple ecosystems. On average, a wildfire season costs anywhere from 7.6-62.8 billion dollars due to fire containment, repair, and restoration [1]. It can take decades to recover from the crippling loss of land and take even longer to fully restore it. However, with the implementation of a robust early detection system, these losses can be significantly reduced. The current process for identifying wildfires involves visual identification, phone call alerts, and media tools primarily driven by park rangers and public reporting. Unfortunately, this system is not preventative and …

Biofidelic Considerations For Improving Standardized Airflow And Firmness Testing For Infant Sleep Products, Wyatt D. Davis

Boise State University Theses and Dissertations

Background

Over the last 30 years, 83 infant fatalities (113 reported, 30 incidental) directly involving crib bumpers have been reported to the Consumer Product Safety Commission. Of these reports, 90% are for infants under a year old, with 61% occurring for infants between 1 and 4 months of age (Safety, 2020). There are currently a few regulations governing the design of crib bumper products, but none test the suffocation risk associated with these products using biofidelic methods.

Goals

We sought to explore the development of new testing methods that can determine the safety of different products and are physiologically representative …

Understanding The Radiation Effects On Fiber Optic Sensors, Sohel Rana

Boise State University Theses and Dissertations

In this dissertation, the effects of radiation (gamma, neutron or mixed gamma and neutron) on optical fiber sensors are studied and new techniques for real-time measurement of radiation-induced macroscopic changes in optical fibers are presented. It is crucial among the research and development efforts in the nuclear energy field to conduct experiments in Advanced Test Reactor (ATR) to support lifetime extension, novel fuels and materials development, better fuel management, and enhanced safety of existing as well as future nuclear power plants (NPP). Due to their unparalleled and unique advantages over traditional sensors, optical fiber sensors are deemed potential candidates for …

State Estimation—Beyond Gaussian Filtering, Haozhan Meng

LSU New Orleans Theses and Dissertations

This dissertation considers the state estimation problems with symmetric Gaussian/asymmetric skew-Gaussian assumption under linear/nonlinear systems. It consists of three parts. The first part proposes a new recursive finite-dimensional exact density filter based on the linear skew-Gaussian system. The second part adopts a skew-symmetric representation (SSR) of distribution for nonlinear skew-Gaussian estimation. The third part gives an optimized Gauss-Hermite quadrature (GHQ) rule for numerical integration with respect to Gaussian integrals and applies it to nonlinear Gaussian filters.

We first develop a linear system model driven by skew-Gaussian processes and present the exact filter for the posterior density with fixed dimensional recursive …

Additive Manufacturing Of Variable Contrast Computed Tomography Anatomical Phantoms Using A Single Feedstock In Fused Filament Fabrication, Cory J. Darling

LSU New Orleans Theses and Dissertations

Anatomical phantoms used in biomedical education and training benefit greatly from Fused filament fabrication’s (FFF) ability to rapidly produce complex and unique models. Current materials and methods used in FFF have limited ability to accurately produce phantoms that can mimic the radiological properties of multiple biological tissues. This research demonstrates that the CT contrast of FFF produced models can be modified by varying the concentration of bismuth oxide in acrylonitrile butadiene styrene (ABS) filaments and a tunable CT contrast that mimics the CT contrast ranging from fatty tissue to cortical bone using a single composite filament without introducing artificial image …

Strain-Based Design Of Steel-Polymer-Steel Composite Pipes, Vul Thang

LSU New Orleans Theses and Dissertations

Many offshore single-wall pipelines and structural failures have occurred in the past. As a result, lives were lost, and billions of dollars were spent. In addition, natural disasters such as earthquake fault zones can cause a large volume of soil movement. This can easily damage single-wall pipelines or piles of fixed offshore platforms in the earthquake fault zone.

Currently, the single-wall pipelines are used for the offshore and onshore oil and gas industry. This research investigated the use of double-wall composite pipe steel-polymer-steel (SPS) in place of single-wall pipe to prevent such failures. The double-wall composite pipe has a larger …

Eco: A Sustainability Education Chatbot, Joey Gruber

Theses/Capstones/Creative Projects

There is a lack of access to information about sustainability from what the climate crisis is to how to recycle properly. For both sustainability-informed and uninformed individuals, learning new information about sustainability and reducing their waste in a way that compliments their lifestyle is time-consuming, requires strategic skills, and can cost them money. ECO is an audio and text-based chatbot that teaches users to be more environmentally conscious through waste reduction.

Cal Poly Fluid Power Vehicle Challenge 2022, Sangmin Sung, Eddy Rodriguez, Travis Welch, Jeremy Baechler, Kevin Pauls

Mechanical Engineering

In this report, the Featherweight Cycles design team puts forth the scope and overview of their design project, discusses background research and competitor analysis, and presents the project’s final design and manufacturing plans. The overall goal of this project is to fabricate and compete in the Fluid Power Vehicle Challenge, hosted by the National Fluid Power Association. To better define the design process, the team researched previous year’s designs from Cal Poly, as well as winning designs from the last two years to form a baseline of knowledge about competing schools’ designs. After researching multiple design paths, Featherweight Cycles chose …

Diffusion Of A Salt In An Aqueous Media, Aldaly Pineda Hernandez

Chemical Engineering Undergraduate Honors Theses

Diffusion is defined as the net transfer of a molecule from a high concentration region to a low concentration region. The concept of diffusion is used in a very important process called "desalination." Desalination is a separation process used to reduce the salt content dissolved in brackish water to make it suitable for human consumption, irrigation, and industrial use.

In desalination plants, it is important to monitor the constantly changing salt content of water, partly due to the diffusive effect. The main purpose of this experiment was to study the diffusion of NaCl in water at two NaCl concentrations. The …

Synthesis And Phase Transition Characterization Of Liquid Crystal Membranes With Slit-Like Pores, Isaac Hopwood

Chemical Engineering Undergraduate Honors Theses

Membranes with slit-like pores have been of interest for some time due to their ability to reject smaller particles than traditional cylindrical-pored membranes at the same fluid flux. However, using liquid crystals as a template for this sort of membrane has not been thoroughly investigated. In this study, the liquid crystal mixture of RM257 (2-Methyl-1,4-phenylene bis(4-(3-(acryloyloxy)propoxy)benzoate)) and 5CB (4-Cyano-4'-pentylbiphenyl) for the purpose of manufacturing membranes with slit-like pores, the phase transition behavior of this LC mixture at various mole fractions of RM257, and the impact of mole fraction of RM257 in the liquid crystal (LC) mixture and membrane manufacturing conditions …

Quantification Of Slit-Like Pores Through Using Liquid Crystals As A Template, Dominique Savage

Chemical Engineering Undergraduate Honors Theses

The purpose of this research is to manufacture a membrane with slit-like pores to achieve particle filtration. Slit-like pore membranes are preferred over conventional membranes with cylindrical pores since slit-like pores have two length scales that can be manipulated to better control cut off and flux through the membrane. This project focuses on manufacturing slit-like pore membranes through the use of two liquid crystals, 1,4-bis[4-(6-acryloyloxyhexyloxy)benzoyloxy]-2-methylbenzene (RM257) and 4-Cyano-4′-pentylbiphenyl (5CB). This method for making slit-like pores has not been widely investigated nor has the morphology of the membrane pores and mechanical properties of such a membrane been addressed. It was found …

Analyzing The Surface Chemistry Of Ni-Fe Hydroxide Alloy Nanoparticles As Catalysts For The Oxygen Evolution Reaction By X-Ray Photoelectron Spectroscopy Analysis, Lauren B. Shepard

Chemical Engineering Undergraduate Honors Theses

Water electrolysis has been proposed as a renewable source of hydrogen, a possible replacement to harmful fossil fuels. This process can be broken down into two half reactions, the hydrogen evolution reaction and the oxygen evolution reaction. Because the oxygen evolution reaction has slow kinetics and a high overpotential to overcome, a catalyst is needed to speed up the kinetics and ensure faster and more efficient production of molecular hydrogen. The use of Ni-Fe hydroxide alloy nanoparticles as a catalyst has been shown to significantly improve the efficiency of the reaction by decreasing the overpotential, making the process more energy …

An Investigation Of Water Obstructions And Related Weather Conditions For Nebraska Roadways, Mark R. Anderson, Logan R. Bundy

Nebraska Department of Transportation: Research Reports

Roadway resilience across the 10,000 miles of road and 3,500 bridges in Nebraska is critical to the economic success of productionand logistics. In a state where historical flooding scenarios, such as the one in March 2019 that caused $150 million in damage,could potentially be increasing, it has become essential to understand the spatial and temporal distribution of high-frequency waterobstruction areas on roadways. Therefore, in order to further investigate these areas, the main objectives of this research were toperform statistical and spatial analyses to quantify the relationship between water obstructions and their associated meteorologicalconditions, and identify the potential linkages between water …

Estimating System And Traveler Costs Due To Lane Closures During Construction And Maintenance Operations, Ernest Tufuor, Li Zhao, Mm Haque, Laurence Rilett Ph.D., John Anderson, Eric Thompson

Nebraska Department of Transportation: Research Reports

Lane closures are used to facilitate activities related to road construction and maintenance or operations. However, there are economic costs associated with lane closures and these may accrue to both the traveling public as well as to traffic agencies. The Nebraska Governor’s office has identified maximizing the effectiveness of lane closures as a priority for the Nebraska Department of Transportation (NDOT). The goal of this project is to assist NDOT in effectively managing the operations of work zones to maximize the effectiveness of lane closures under Nebraska conditions. This report summarizes the findings of the current state of the practice …

Estimating System And Traveler Costs Due To Lane Closures During Construction And Maintenance Operations, Ernest Tufuor, Lianlin Zhao, Mm Shakiul Haque, Laurence Rilett, John Anderson, Eric Thompson

Nebraska Department of Transportation: Research Reports

Lane closures are used to facilitate activities related to road construction and maintenance or operations. However, there are economic costs associated with lane closures and these may accrue to both the traveling public as well as to traffic agencies. The Nebraska Governor’s office has identified maximizing the effectiveness of lane closures as a priority for the Nebraska Department of Transportation (NDOT). The goal of this project is to assist NDOT in effectively managing the operations of work zones to maximize the effectiveness of lane closures under Nebraska conditions. This report summarizes the findings of the current state of the practice …

Porous Silicon Photonics For Label-Free Interferometric Biosensing And Flat Optics, Tahmid Hassan Talukdar

All Dissertations

This dissertation uses porous silicon as a material platform to explore novel optical effects in three domains: (i) It studies dispersion engineering in integrated waveguides to achieve high performance group index sensing. With proper design parameters, the sensor waveguides can theoretically achieve 6 times larger group index shift compared to the actual bulk effective refractive index shift. We demonstrate the guided mode confinement factor to be a key parameter in design and implementation of these waveguides. (ii) It explores multicolor laser illumination to experimentally demonstrate perceptually enhanced colorimetric sensing, overcoming the limitations faced by many contemporary colorimetric sensors. Our technique …

Using Safety Performance Models, Autonomous Vehicle Data, And Machine Learning To Develop Contextual Complexity Criteria To Establish A Standardized Process For On-Road Evaluation Of Medically At-Risk Drivers Considering Static And Dynamic Factors Of The Roadway Environment, Vijay Bendigeri

All Dissertations

The field of transportation engineering has an opportunity to positively impact the medical community, specifically the clinicians who evaluate, train, and rehabilitate at-risk drivers. Driving Rehabilitation Specialists (DRSs) have an essential role in making roads safer for medically-at-risk drivers, their passengers, and other road users. DRSs conduct on-road driving evaluations, which are considered the gold standard to make fitness-to-drive decisions due to their high face validity. Most DRSs use a fixed route, meaning the exact same route is used to evaluate each client. When a DRS develops a fixed route, that clinician identifies characteristics of the roadway they think are …

Optimized Damage Assessment And Recovery Through Data Categorization In Critical Infrastructure System., Shruthi Ramakrishnan

Graduate Theses and Dissertations

Critical infrastructures (CI) play a vital role in majority of the fields and sectors worldwide. It contributes a lot towards the economy of nations and towards the wellbeing of the society. They are highly coupled, interconnected and their interdependencies make them more complex systems. Thus, when a damage occurs in a CI system, its complex interdependencies make it get subjected to cascading effects which propagates faster from one infrastructure to another resulting in wide service degradations which in turn causes economic and societal effects. The propagation of cascading effects of disruptive events could be handled efficiently if the assessment and …

Design, Fabrication, And Characterization Of An Array Of Graphene Based Variable Capacitors, Millicent Nkirote Gikunda

Graduate Theses and Dissertations

Since it was first isolated and characterized in 2004, graphene has shown the potential for a technological revolution. This is due to its amazing physical properties such as high electrical conductivity, high thermal conductivity, and extreme flexibility. Freestanding graphene membranes naturally possesses an intrinsic rippled structure, and these ripples are in constant random motion even room temperatures. Occasionally, the ripples undergo spontaneous buckling (change of curvature from concave to convex and vice versa) and the potential energy associated with this is a double well potential. This movement of graphene is a potential source of vibrational energy.

In this dissertation, we …

High Power Density And High Efficiency Converter Topologies For Renewable Energy Conversion And Ev Applications, Dereje Lemma Woldegiorgis

Graduate Theses and Dissertations

This dissertation work presents two novel converter topologies (a three-level ANPC inverter utilizing hybrid Si/SiC switches and an Asymmetric Alternate Arm Converter (AAAC) topology) that are suitable for high efficiency and high-power density energy conversion systems. The operation principle, modulation, and control strategy of these newly introduced converter topologies are presented in detail supported by simulation and experimental results. A thorough design optimization of these converter topologies (Si/SiC current rating ratio optimization and gate control strategies for the three-level ANPC inverter topology and component sizing for the asymmetric alternate arm converter topology) are also presented.

Performance comparison of the proposed …

A Novel Data Lineage Model For Critical Infrastructure And A Solution To A Special Case Of The Temporal Graph Reachability Problem, Ian Moncur

Graduate Theses and Dissertations

Rapid and accurate damage assessment is crucial to minimize downtime in critical infrastructure. Dependency on modern technology requires fast and consistent techniques to prevent damage from spreading while also minimizing the impact of damage on system users. One technique to assist in assessment is data lineage, which involves tracing a history of dependencies for data items. The goal of this thesis is to present one novel model and an algorithm that uses data lineage with the goal of being fast and accurate. In function this model operates as a directed graph, with the vertices being data items and edges representing …

Modeling Damage Spread, Assessment, And Recovery Of Critical Systems, Justin Burns

Graduate Theses and Dissertations

Critical infrastructure systems have recently become more vulnerable to attacks on their data systems through internet connectivity. If an attacker is successful in breaching a system’s defenses, it is imperative that operations are restored to the system as quickly as possible. This thesis focuses on damage assessment and recovery following an attack. A literature review is first conducted on work done in both database protection and critical infrastructure protection, then the thesis defines how damage affects the relationships between data and software. Then, the thesis proposes a model using a graph construction to show the cascading affects within a system …

Layered Epoxide-Amine/Boron Nitride/Graphene Nanocomposites For Enhanced Multifunctional Shielding, Alyssa J. Necaise

Honors Theses

The development of high-power electromagnetic wave sources in the modern era has the ability to interfere with aircraft electronics and cause localized heating – necessitating advanced materials for electromagnetic interference (EMI) and thermal shielding. Multifunctional nanoparticles dispersed within polymer matrices can combat these issues; however, the best way to combine thermally and electrically conductive species to maximize electromagnetic interference shielding and thermal shielding is undetermined. Multifunctional layered epoxide/amine nanocomposites were prepared from tetra and octafunctional epoxide monomers (TGDDM and SU-8), 4,4-DDS tetrafunctional amine curative, and 1 wt.% hexagonal boron nitride nanoplatelets and/or 1 wt.% graphene nanoplatelets to form monolayer and …

Infrared Electric Field Enhancement Via A Hyperbolic-Metalens-Coupled Nanoantenna, Mohamed Jebril Kyamo

Theses and Dissertations

The development of near- and mid-infrared applications requires high enhancement of the electric field intensity (EFI) and a high absorption cross-section of the electric field. The high enhancement of EFI can be obtained by concentrating optical energy to areas much smaller than the diffraction limit or by using surface plasmon polaritons (SPPs). Noble metals such as gold (Au) or silver (Ag) are not feasible for infrared (IR) applications because of high losses, lack of tunability, low resolution, and low-intensity enhancement. Our methods to solve these problems are based on appropriate metamaterial selection and on coupling systems with optimization of their …