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Articles 31051 - 31080 of 196370

Full-Text Articles in Engineering

Quantifying Fibronectin Mechanical Properties Using Antibody-Mediated Optical Tweezing (Amot), Caleb Dalton Jan 2023

Quantifying Fibronectin Mechanical Properties Using Antibody-Mediated Optical Tweezing (Amot), Caleb Dalton

Theses and Dissertations

Despite decades of investigations into fibronectin (FN) fibrillogenesis, fibril mechanics remain unclear. One of the most important roles for FN fibrils is in the arena of cellular mechanotransduction. Numerous studies have demonstrated that cells sense and respond to the mechanical properties of their surroundings; since FN fibrils are a major constituent of the ECM that links cells to their surroundings, mechanotransduction cannot be fully understood without understanding the mechanical properties of FN fibrils. In this proposal, a novel biomechanical assay is developed to probe isolated FN fibrils and quantify their response to specific loading conditions. This will be accomplished by …


Thermal Performance And Fluid Flow Studies Of Twisted Tape Inserts Using Scaled Surrogate Fluids For Molten Salt Energy Applications, Arturo Cabral Jan 2023

Thermal Performance And Fluid Flow Studies Of Twisted Tape Inserts Using Scaled Surrogate Fluids For Molten Salt Energy Applications, Arturo Cabral

Theses and Dissertations

Global energy consumption is expected to increase with population growth and innovative clean sources of energy are sought out that can help meet the needs of a continuously power-hungry world. Some of these innovative sources of energy use molten salts as their operating and cooling fluid, such as fission reactors, fusion reactors, and solar power with energy storage. Molten salts are considered due to their efficient heat transfer properties, thermal energy storage capabilities, and high operating temperatures. To expedite their deployment, a further understanding of the heat transfer systems is required to accurately design and develop the heat transfer components …


Virtual Plc Platform For Security And Forensics Of Industrial Control Systems, Syed Ali Qasim Jan 2023

Virtual Plc Platform For Security And Forensics Of Industrial Control Systems, Syed Ali Qasim

Theses and Dissertations

Industrial Control Systems (ICS) are vital in managing critical infrastructures, including nuclear power plants and electric grids. With the advent of the Industrial Internet of Things (IIoT), these systems have been integrated into broader networks, enhancing efficiency but also becoming targets for cyberattacks. Central to ICS are Programmable Logic Controllers (PLCs), which bridge the physical and cyber worlds and are often exploited by attackers. There's a critical need for tools to analyze cyberattacks on PLCs, uncover vulnerabilities, and improve ICS security. Existing tools are hindered by the proprietary nature of PLC software, limiting scalability and efficiency.

To overcome these challenges, …


Computational Modeling Of Temporal Eeg Responses To Cyclic Binary Visual Stimulus Patterns, Connor M. Delaney Jan 2023

Computational Modeling Of Temporal Eeg Responses To Cyclic Binary Visual Stimulus Patterns, Connor M. Delaney

Theses and Dissertations

The human visual system serves as the basis for many modern computer vision and machine learning approaches. While detailed biophysical models of certain aspects of the visual system exist, little work has been done to develop an end-to-end model from the visual stimulus to the signals generated at the visual cortex measured via the scalp electroencephalogram (EEG). The creation of such a model would not only provide a better understanding of the visual processing pathways but would also facilitate the design and evaluation of more robust visual stimuli for brain-computer interfaces (BCIs). A novel experiment was designed and conducted where …


Advanced Modeling And Innovative Transcranial Magnetic Stimulation Coil Designs For The Treatment Of Neurological Disorders, Mohannad Tashli Jan 2023

Advanced Modeling And Innovative Transcranial Magnetic Stimulation Coil Designs For The Treatment Of Neurological Disorders, Mohannad Tashli

Theses and Dissertations

Transcranial magnetic stimulation (TMS) is a safe, effective and non-invasive treatment for several mental and psychiatric disorders. TMS is an FDA approved treatment and is commonly applied to patients who do not respond to medications for the treatment of clinical depression, smoking cessation, obsessive-compulsive disorder and migraine. Recently, there has been an increase in the development of electromagnetic neuromodulation techniques targeted at enhancing the effectiveness of TMS devices for the treatment of mental diseases. In TMS stimulation, focality is an important factor which determines the specificity of the pulses induced in different brain tissues. The electromagnetic pulses must be confined …


Characterization And Decoding Of Speech Activity From Intracranial Signals, Pedram Zanganeh Soroush Jan 2023

Characterization And Decoding Of Speech Activity From Intracranial Signals, Pedram Zanganeh Soroush

Theses and Dissertations

Speech is the first and foremost means of human communication. Millions of people worldwide suffer from severe speech disorders due to neurological diseases such as amyotrophic lateral sclerosis (ALS), brain stem stroke, and severe paralysis. A speech neuroprosthesis that decodes speech directly from neural signals could dramatically improve life for these individuals. Recent studies have demonstrated that it is possible to decode and synthesize various aspects of acoustic speech directly from intracranial measurements of electrophysiological brain activity. For those who have completely lost the ability to speak, the objective is to synthesize acoustic speech directly from brain activity during imagined …


Fluid-Structure Interaction Adopting Full Water Hammer Model, A. O. Abdelbaki, A-R. Abdel-Rahim, Mostafa. M. Awad, W. M. Elawady Jan 2023

Fluid-Structure Interaction Adopting Full Water Hammer Model, A. O. Abdelbaki, A-R. Abdel-Rahim, Mostafa. M. Awad, W. M. Elawady

Mansoura Engineering Journal

A full water hammer model is developed and coded in the Mathcad software environment. The developed model constitutes a general platform for studying the water hammer transient incorporating the most legitimate parameters that affect the phenomenon. In this study, the fluid-structure interactions during water hammer transients were investigated through the affecting parameters such as pipeline material hysteresis behavior what is so-called viscoelasticity (VE) behavior, and unsteady friction (UF) with different coupling mechanisms such as friction coupling, Poisson coupling, and junction coupling which may be due to a free-to-move valve for system with a reservoir-pipe-valve. Based on the numerical results corresponding …


Unveiling Similarities And Differences Between Cutaneous And Ocular Melanomas, Abdallah Badou, Nour El Imane Issam Salah, Mohamed Elbelhadji Jan 2023

Unveiling Similarities And Differences Between Cutaneous And Ocular Melanomas, Abdallah Badou, Nour El Imane Issam Salah, Mohamed Elbelhadji

Health Sciences

Melanomas are outstandingly aggressive cancers, still their incidence is increasing. They can occur in the skin as cutaneous melanoma or in the eye as ocular melanoma. Their pathogenesis is generally similar; however, the prognosis of ocular melanoma patients is still poor, due to its special genetic profile and tumor microenvironment. Here we review the similarities and differences between cutaneous and ocular melanoma, with a focus on their prognostic significance, their molecular signature, and their tumor microenvironment, in order to understand the strategies adopted to escape immune response. Gathering and understanding available knowledge of melanomas and their specificities may help to …


Full Body Harness Design Modifications And Evaluation: A Senior Design Project, Martin Mead, Jordan Von Seggern Jan 2023

Full Body Harness Design Modifications And Evaluation: A Senior Design Project, Martin Mead, Jordan Von Seggern

The Journal of Undergraduate Research

Full-body harness (FBH) is critical for the safe operation of industrial and recreational activities, from installing and maintaining infrastructure such as wind turbines to ziplining and mountaintop adventures. However, harness design remains in the proprietary information of companies with limited technical information available for improvements or readjustments to specialized applications. As the outcome of the Capstone project, the paper focuses on multiple technical aspects and the engineering processes for designing FBH for ziplining recreational users, from selecting and testing materials for operation in cold weather to improvements in design and manufacturing for user comfort. The project is guided by technical …


Implicit Racial Bias: A Human Computer Interaction Study Using Eye Tracker, Wenfan Zhang Jan 2023

Implicit Racial Bias: A Human Computer Interaction Study Using Eye Tracker, Wenfan Zhang

Master's Projects

Contemporary Human-Computer Interaction (HCI) research has an increasing emphasis on reducing ethnicity bias. The study presents a new method to explore and reduce biases using detailed experiments. The experimental procedure involves presenting participants with images of ethnically diverse characters across three conditions. The study's results significantly illuminate ethnicity bias in character selection dynamics. Participants exposed to targeted training interventions displayed a significant shift in preferences for characters engaged in intellectual activities. Notably, this shift was influenced by the ethnicity of the characters involved. Interestingly, the eye-tracking data unveiled distinct patterns of cognitive load, characterized by slower response times and greater …


Enhancing Driver Distraction Detection Through The Synergy Of Deep And Traditional Machine Learning, Gowtham Chandrasekaran Jan 2023

Enhancing Driver Distraction Detection Through The Synergy Of Deep And Traditional Machine Learning, Gowtham Chandrasekaran

Master's Projects

Distracted driving is a major contributor to motor vehicle accidents, causing injury and loss of life. It is one of the major factors that affect the overall driving behavior of a person. Insurance companies take into consideration factors like gender, age, etc. to set insurance premiums for their customers. Today, machine learning and artificial intelligence can eradicate this bias. A machine learning model can analyze driving behavior, such as the frequency and severity of accidents, the speed at which they drive, and their habits such as distracted driving. Based on this information, the model can then determine the risk of …


Spartandark: Anonymity Model Integration With A Blockchain Network Using Spartangold, Nishanth Uchil Jan 2023

Spartandark: Anonymity Model Integration With A Blockchain Network Using Spartangold, Nishanth Uchil

Master's Projects

Demand for blockchain ecosystems has seen exponential growth in recent times due to its decentralized nature and trustless verification process for the transactions involved. However, transaction data needs to be leveraged for verification, which coupled with the transparent nature of the blockchain ledger, provides sufficient data for malicious entities to reveal identities and even financial history of users. Data masking techniques have been employed over the years to make blockchain transactions anonymous, making them resistant to identity analysis, a key set of methods being zero-knowledge proof (zk-proof) protocols that guarantee zero data leak. In this research, we develop SpartanDark, a …


Enhancing The Queueing Process For Yioop's Scheduler, Gargi Sheguri Jan 2023

Enhancing The Queueing Process For Yioop's Scheduler, Gargi Sheguri

Master's Projects

Indexing in search engines is the process of storing information related to crawled pages to facilitate searches. A crucial determinant of the success of a search engine is the efficiency of the indexing process utilized, which greatly affects both the speed and relevancy of search results. Yioop is an open-source web search engine that employs an inverted index strategy, wherein each term is mapped to a list of the documents it appeared in while crawling.

The primary aim of this project is to better the indexing system used by Yioop, and thus improve the quality of the Search Engine Results …


Temporal Dilation In Video Resnet For Sign Language Translation, Xiaoqian Yang Jan 2023

Temporal Dilation In Video Resnet For Sign Language Translation, Xiaoqian Yang

Master's Projects

Sign languages, vital for communication among the deaf and hard-of-hearing (DHH) people, face a significant linguistic diversity challenge with over 200 distinct sign languages worldwide. Bridging this communication gap is a priority. Traditional tools like interpreters and costly translation devices have limitations. This project aims to use deep learning techniques to develop a model capable of recognizing sign language from short videos. Our model not only recognizes the sign from a single video clip, but is also capable of making prediction of consecutive pairs of signs. To achieve zero-short gesture sequence recognition, we propose a novel temporal dilation strategy, converting …


Graphical User Interface For Evidential Reasoning Models, Rohin Gopalakrishnan Jan 2023

Graphical User Interface For Evidential Reasoning Models, Rohin Gopalakrishnan

Master's Projects

The Capri system is an evidential reasoning system based on the belief function calculus to support automated reasoning and decision making in uncertain environments. Example domains of application include, medical diagnosis, as well as identifying biological biomarkers. The purpose of this project is to build a Python web-based and app-based Graphical User Interface (GUI), called PyGrapher, that facilitates building graphical evidential reasoning models. The graphical models built using PyGrapher will then be converted to a form that is suitable for input to the Capri system. The PyGrapher system provides an intuitive means to build and manipulate evidential reasoning models as …


Nuancenet: Comparative Analysis Of Ai In Complex Language Interpretation For Disaster Detection, Pavan Koushik Kommuri Jan 2023

Nuancenet: Comparative Analysis Of Ai In Complex Language Interpretation For Disaster Detection, Pavan Koushik Kommuri

Master's Projects

Disaster Detection using Twitter content is critical for emergency response, but accurately identifying relevant tweets remains challenging due to nuances, informal language, and emotional expressions. This paper presents a comparative analysis between traditional Machine Learning models, Deep Learning models and Large Language Models (LLM) for classifying disaster vs. non-disaster tweets. While existing works have applied pattern recognition and dataset-specific learning, LLMs with their deeper understanding of linguistics and semantics can potentially handle the complexities of tweets more effectively. This study leverages LLMs including Llama2, Mistral, and Falcon, Open AI GPT 3.5, hypothesizing their superior contextual comprehension will excel in tweets …


Variation Of Moisture Content And Temperature Under The Road Shoulder Improved With Wicking Geotextile, Javad Galinmoghadam, Xiong Zhang Jan 2023

Variation Of Moisture Content And Temperature Under The Road Shoulder Improved With Wicking Geotextile, Javad Galinmoghadam, Xiong Zhang

Civil, Architectural and Environmental Engineering Faculty Research & Creative Works

Several Pavement Distresses Are Associated with Excess Water in the Pavement System. Hence, Controlling Subsurface Water is Crucial to Pavement's Long-Term Performance. Improving Pavement Drainage is Commonly Used to Control the Water Content in Pavement Layers. Conventional Drainage Systems Can Work under Saturated Conditions but Cannot Effectively Drain Capillary Water. a New Type of Wicking Geotextile Has Been Developed that Can Drain Water under Both Saturated and Unsaturated Conditions. in This Study, the Performance of This New Type of Geotextile in Draining Water from a Paved Road Shoulder is Evaluated. a Full-Scale Test Section Along Interstate 44 Was Constructed and …


Hardware-In-The-Loop And Digital Twin Enabled Autonomous Robotics-Assisted Environment Inspection, Johnny Li, Bo Shang, Iresh Jayawardana, Genda Chen Jan 2023

Hardware-In-The-Loop And Digital Twin Enabled Autonomous Robotics-Assisted Environment Inspection, Johnny Li, Bo Shang, Iresh Jayawardana, Genda Chen

Civil, Architectural and Environmental Engineering Faculty Research & Creative Works

Empowered by the advanced 3D sensing, computer vision and AI algorithm, autonomous robotics provide an unprecedented possibility for close-up infrastructure environment inspection in an efficient and reliable fashion. Deep neural network (DNN) learning algorithms, pretrained on the large database can empower real-time object detection as well as fully autonomous, safe robotic navigation in unstructured environments while avoiding the potential obstacle. However, the development and deployment of the robots, inspection planning and operation procedures are still tedious and segmented with tremendous manual intervention during environmental inspection and anomaly monitoring. The proposed digital twin approach is able to provide a virtual representation …


Field Reconnaissance And Observations From The February 6, 2023, Turkey Earthquake Sequence, Gulen Ozkula, Robert K. Dowell, Tugce Baser, Jui Liang Lin, Ozgun A. Numanoglu, Okan Ilhan, C. Guney Olgun, Cheng Wei Huang, Tunc Deniz Uludag Jan 2023

Field Reconnaissance And Observations From The February 6, 2023, Turkey Earthquake Sequence, Gulen Ozkula, Robert K. Dowell, Tugce Baser, Jui Liang Lin, Ozgun A. Numanoglu, Okan Ilhan, C. Guney Olgun, Cheng Wei Huang, Tunc Deniz Uludag

Civil, Architectural and Environmental Engineering Faculty Research & Creative Works

On February 6, 2023, a sequence of earthquakes hit Kahraman Maras, Turkey, with magnitudes of M w = 7.8 and 7.5, at 4:17 am and 1:24 pm local time, respectively. According to the records, the M w = 7.8 event was the biggest earthquake since the 1939 Erzincan earthquake of the same magnitude and second-strongest recorded after the 1668 North Anatolia Earthquake. However, it was the most devastating earthquake in the history of Turkey in terms of structural and geotechnical damage and fatalities caused by this. The objective of this article is to explore the aftermath of this major seismic …


Incremental Development Model Using Vacant Buildings For Affordable Housing, Seogjae Choi, Boyoung Michelle Huh Jan 2023

Incremental Development Model Using Vacant Buildings For Affordable Housing, Seogjae Choi, Boyoung Michelle Huh

Civil, Architectural and Environmental Engineering Faculty Research & Creative Works

Vacant properties have increased and become a problem in cities in the US. Few studies addressed how to utilize vacant properties for affordable housing despite they can be a great resource for affordable housing. To improve affordable housing sustainability, researchers recommended incremental development because it can satisfy residents' dynamic demands over time and engage them in house design. This can be implemented by utilizing vacant buildings to maximize their potential for affordable housing. Through the literature review, critical sustainability criteria for affordable housing are yielded. This paper demonstrates how the incremental development of vacant buildings satisfies the critical sustainability criteria. …


An Eye Tracking Based Framework For Safety Improvement Of Offshore Operations, Muhammad A. Raza, Raj Kiran, Saima Ghazal, Ziho Kang, Saeed Salehi, Edward Cokely, Jiwon Jeon Jan 2023

An Eye Tracking Based Framework For Safety Improvement Of Offshore Operations, Muhammad A. Raza, Raj Kiran, Saima Ghazal, Ziho Kang, Saeed Salehi, Edward Cokely, Jiwon Jeon

Mining Engineering Faculty Research & Creative Works

Offshore drilling operations consist of complex and high-risk processes. Lack of situational awareness in drilling operations has become an important human factor issue that causes safety accidents. Prolonged work shifts and fatigue are some of the crucial issues that impact performance. Eye tracking technology can be used to distinguish the degree of awareness or alertness of participants that might be related to fatigue or onsite distractions. Oculomotor activity can be used to obtain visual cues that can quantify the drilling operators' situational awareness that might enable us to develop warning alarms to alert the driller. Such systems can help reduce …


Electrode And Electrolyte Design To Develop Advanced Battery Technologies For Large Scale Energy Storage, Wei He Jan 2023

Electrode And Electrolyte Design To Develop Advanced Battery Technologies For Large Scale Energy Storage, Wei He

Electronic Theses and Dissertations

Large-scale energy storage devices play a key role in regulating the renewable energy to build a carbon-free sustainable future, but the widely used lithium-ion batteries cannot meet the demands because of the limited lithium resource and high cost. Thus, it is urgent to develop next-generation battery technologies with low cost and high safety. Sodium-ion battery is considered as a promising candidate due to the abundant sodium resources and low cost. Its practical application, however, is hindered by the absence of the advanced electrode materials. The tin-based anodes deliver high theoretical capacities and show great promise for the sodium-ion batteries, but …


Quantifying The Effects Of Hvac Operation To Mitigate Aerosol Concentration In A Classroom Using Cfd, Scott Deprez Jan 2023

Quantifying The Effects Of Hvac Operation To Mitigate Aerosol Concentration In A Classroom Using Cfd, Scott Deprez

Electronic Theses and Dissertations

Heating, ventilation, and air conditioning (HVAC) is a complex mechanical system for the transition of air between outdoor and indoor areas. These systems are directly responsible for temperature, humidity, and air flow into any given space, thereby providing a level of comfort to those who live indoors. These systems account for 52 percent of U.S. energy consumption. When designing HVAC systems, indoor air quality (IAQ) is the main focus for achieving safe and clean air, such as in the case of airborne diseases. HVAC systems are responsible for the flow of air in indoor spaces and thereby expand the transmissible …


Electrospun Recycled Polyethylene Terephthalate Microfibers As An Asphalt Mix Additive, Debbrata Datta Jan 2023

Electrospun Recycled Polyethylene Terephthalate Microfibers As An Asphalt Mix Additive, Debbrata Datta

Electronic Theses and Dissertations

In recent decades, the use of different types of fibers in asphalt has become increasingly popular. Fibers are used in an asphalt mix to improve its durability and resistance against distresses such as rutting and cracking due to repetitive vehicle loading at high temperatures, and low-temperature contraction. Consequently, accurate rheological and performance characterization of asphalt binders and mixes containing fibers is of vital importance. With increased concerns over the environmental disruptions as a result of disposing end-of-life plastics in landfills and the need for improving sustainability of the construction materials, incorporating plastic in construction materials has always been an important …


Nitrogen Plasma Treatment On Triple Cation Mixed Halide Perovskite Surface For High Efficiency Perovskite Solar Cells, Buddhi Sagar Lamsal Jan 2023

Nitrogen Plasma Treatment On Triple Cation Mixed Halide Perovskite Surface For High Efficiency Perovskite Solar Cells, Buddhi Sagar Lamsal

Electronic Theses and Dissertations

No abstract provided.


Analyzing The Effectiveness Of The Gurney Method For Small Scale Fragmentation Propulsion Using Exploding Bridgewire Detonators, Emily M. Johnson, Rachel L. Bauer, Catherine E. Johnson Jan 2023

Analyzing The Effectiveness Of The Gurney Method For Small Scale Fragmentation Propulsion Using Exploding Bridgewire Detonators, Emily M. Johnson, Rachel L. Bauer, Catherine E. Johnson

Mining Engineering Faculty Research & Creative Works

Explosives are common in military, mining, and construction applications where the explosive properties are understood, but mechanics of how the explosive's energy fragments and throws materials are less known. Considering the type of confining material around an explosive, creates variability in fragmentation behavior due to the individual material characteristics. The most common method for assessing fragmentation behavior is the Gurney method, which eliminates any consideration of fragmenting material properties. The Gurney method assumes that, on a large scale, the inconsistencies in material are irrelevant and only the mass of the confiner need be considered. However, it is known in many …


Explosion Resistance Of Reinforced Concrete Refuge Alternative Wall Under Certain Abutment Loading, K. E. Karadeniz, D. Guner, Taghi Sherizadeh Jan 2023

Explosion Resistance Of Reinforced Concrete Refuge Alternative Wall Under Certain Abutment Loading, K. E. Karadeniz, D. Guner, Taghi Sherizadeh

Mining Engineering Faculty Research & Creative Works

Build-in-place (BIP) refuge alternatives (RAs) are used to provide safe havens for miners unable to escape their working area after an accident like an explosion. These underground infrastructures are built over time in various locations and might expose to mining-induced stresses. The convergences related to these stress redistributions around the mine openings might change their structural integrity and, subsequently, the explosion resistivity. Studying the effect of increasing vertical load like abutment stress on such underground mine stopping for the explosion resistance is difficult because repetitive explosion experiments on these structures are perilous and challenging. This study uses two case studies …


Nonprehensile Manipulation Of A Stick Using Impulsive Forces, Aakash Khandelwal, Nilay Kant, Ranjan Mukherjee Jan 2023

Nonprehensile Manipulation Of A Stick Using Impulsive Forces, Aakash Khandelwal, Nilay Kant, Ranjan Mukherjee

Mechanical and Aerospace Engineering Faculty Research & Creative Works

The problem of nonprehensile manipulation of a stick in three-dimensional space using intermittent impulsive forces is considered. The objective is to juggle the stick between a sequence of configurations that are rotationally symmetric about the vertical axis. The dynamics of the stick is described by five generalized coordinates and three control inputs. Between two consecutive configurations where impulsive inputs are applied, the dynamics is conveniently represented by a Poincaré map in the reference frame of the juggler. Stabilization of the orbit associated with a desired juggling motion is accomplished by stabilizing a fixed point on the Poincaré map. The Impulse …


Evaluation Of Low-Cost Radiometer For Surface Reflectance Re-Trieval And Orbital Sensor’S Validation, Dinithi Siriwardana Pathiranage Jan 2023

Evaluation Of Low-Cost Radiometer For Surface Reflectance Re-Trieval And Orbital Sensor’S Validation, Dinithi Siriwardana Pathiranage

Electronic Theses and Dissertations

This paper evaluates the Arable Mark 2 sensor, an automated and low-cost radiometer, for its potential to retrieve surface reflectance data and validate orbital sensors such as the Landsat-8 (L8) Operational Land Imager (OLI) Level 2 product. While orbital sensors are widely used for monitoring solar radiation changes, managing natural resources, and understanding climatic trends, atmospheric effects can make it challenging to obtain accurate measurements. Equipped with multiple sensors, including long-wave and short-wave radiometers, the Arable Mark 2 sensor can measure upwelling and downwelling irradiance to calculate surface reflectance. To assess the accuracy and consistency of the Arable Mark 2 …


Modeling Of Transport In Anatomic Respiratory Airways: Applications In Targeted Drug Delivery And Airborne Pathogenic Transmissions, Mohammad Mehedi Hasan Akash Jan 2023

Modeling Of Transport In Anatomic Respiratory Airways: Applications In Targeted Drug Delivery And Airborne Pathogenic Transmissions, Mohammad Mehedi Hasan Akash

Electronic Theses and Dissertations

This thesis aims to explore the potential of improving the efficacy of drugs for treatment of viral infections by targeting the nasopharynx, which is commonly the first site of infection for many viral pathogens. Currently, intranasal sprays are used, but the standard protocol (“Current Use” or CU) results in suboptimal drug deposition at the nasopharynx. To address this issue, an “Improved Use” or, IU protocol has been proposed, which involves pointing the spray bottle at a shallower angle and aiming slightly towards the cheeks. The IU delivery is also robust to perturbations in spray direction, which highlights the practical utility …