Open Access. Powered by Scholars. Published by Universities.®

Engineering Commons™

Open Access. Powered by Scholars. Published by Universities.®

Discipline
Institution
Keyword
Publication Year
Publication
Publication Type
File Type

Articles 18301 - 18330 of 198056

Full-Text Articles in Engineering

Federated Learning Based Autoencoder Ensemble System For Malware Detection On Internet Of Things Devices, Steven Edward Arroyo Jun 2024

Federated Learning Based Autoencoder Ensemble System For Malware Detection On Internet Of Things Devices, Steven Edward Arroyo

Theses and Dissertations

New technologies are being introduced at a rate faster than ever before and smaller in size. Due to the size of these devices, security is often difficult to implement. The existing solution is a firewall-segmented “IoT Network” that only limits the effect of these infected devices on other parts of the network. We propose a lightweight unsupervised hybrid-cloud ensemble anomaly detection system for malware detection. We perform transfer learning using a generalized model trained on multiple IoT device sources to learn network traffic on new devices with minimal computational resources. We further extend our proposed system to utilize federated learning …


How Ai And Digitalization Can Help To Improve Managing Projects In Lean Manufacturing & Supply Chain Environment, Abhijeet Hange Jun 2024

How Ai And Digitalization Can Help To Improve Managing Projects In Lean Manufacturing & Supply Chain Environment, Abhijeet Hange

Harrisburg University Dissertations and Theses

This research examines how digitalization and machine learning (ML) revolutionize project management in supply chain and lean manufacturing settings. To improve the efficiency and caliber of their operational procedures, Acuity Brands, Amazon, Walmart, Apple, and other medium-sized businesses—which are at the center of today's competitive markets—are resorting to automation and digitalization. With an emphasis on the fusion of digital and artificial intelligence (AI), the paper explores how successful transformation initiatives are essential to the automation and digitization of manufacturing and distribution hubs. The study uses quantitative methods approach to evaluate the benefits and drawbacks of these technology integrations by integrating …


Chemical Herding As A Multiplicative Factor For Top-Down Manipulation Of Colloids, Mark N. Mcdonald, Douglas R. Tree, Cameron K. Peterson Jun 2024

Chemical Herding As A Multiplicative Factor For Top-Down Manipulation Of Colloids, Mark N. Mcdonald, Douglas R. Tree, Cameron K. Peterson

Faculty Publications

Colloidal particles can create reconfigurable nanomaterials, with applications such as color-changing, self-repairing, and self-regulating materials and reconfigurable drug delivery systems. However, top-down methods for manipulating colloids are limited in the scale they can control. We consider here a new method for using chemical reactions to multiply the effects of existing top-down colloidal manipulation methods to arrange large numbers of colloids with single-particle precision, which we refer to as chemical herding. Using simulation-based methods, we show that if a set of chemically active colloids (herders) can be steered using external forces (i.e., electrophoretic, dielectrophoretic, magnetic, or optical forces), then a larger …


A Comprehensive Study On The Impact Of Human Hair Fiber And Millet Husk Ash On Concrete Properties: Response Surface Modeling And Optimization, Naraindas Bheel, Muhammad Alamgeer Shams, Samiullah Sohu, Abdul Salam Buller, Taoufik Najeh, Fouad Ismail Ismail, Omrane Benjeddou Jun 2024

A Comprehensive Study On The Impact Of Human Hair Fiber And Millet Husk Ash On Concrete Properties: Response Surface Modeling And Optimization, Naraindas Bheel, Muhammad Alamgeer Shams, Samiullah Sohu, Abdul Salam Buller, Taoufik Najeh, Fouad Ismail Ismail, Omrane Benjeddou

Department of Civil and Environmental Engineering: Faculty Publications

Revolutionizing construction, the concrete blend seamlessly integrates human hair (HH) fibers and millet husk ash (MHA) as a sustainable alternative. By repurposing human hair for enhanced tensile strength and utilizing millet husk ash to replace sand, these materials not only reduce waste but also create a durable, eco-friendly solution. This groundbreaking methodology not only adheres to established structural criteria but also advances the concepts of the circular economy, representing a significant advancement towards environmentally sustainable and resilient building practices. The main purpose of the research is to investigate the fresh and mechanical characteristics of concrete blended with 10–40% MHA as …


Emergent Magnetism And Hyperthermia In Phase- And Size-Tunable Iron Oxide Nanostructures, K Mudiyanselage Tharindu Supun Bandara Attanayake Jun 2024

Emergent Magnetism And Hyperthermia In Phase- And Size-Tunable Iron Oxide Nanostructures, K Mudiyanselage Tharindu Supun Bandara Attanayake

USF Tampa Graduate Theses and Dissertations

Iron oxide nanoparticles (IONPs) hold immense potential across diverse fields, from spintronics, magnetic hyperthermia to drug delivery, biodetection, and magnetic resonance imaging. Unlocking these applications hinges on our ability to tailor the magnetic properties of IONPs, and this dissertation presents novel and powerful approaches for enhancing magnetic and hyperthermic responses of multiphase iron oxide nanostructures. This is achieved by manipulating their phase volume fraction, size, and shape with a focus on the magnetic tunability of nanostructures via strategic control over structural and environmental parameters. The aforementioned has been achieved by the following three key approaches: (i) phase-tunability of iron oxide …


Pixel-Mps: Stochastic Embedding And Density-Based Clustering Of Image Patterns For Pixel-Based Multiple-Point Geostatistical Simulation, Adel Asadi, Snehamoy Chatterjee Jun 2024

Pixel-Mps: Stochastic Embedding And Density-Based Clustering Of Image Patterns For Pixel-Based Multiple-Point Geostatistical Simulation, Adel Asadi, Snehamoy Chatterjee

Michigan Tech Publications

Multiple-point geostatistics (MPS) is an established tool for the uncertainty quantification of Earth systems modeling, particularly when dealing with the complexity and heterogeneity of geological data. This study presents a novel pixel-based MPS method for modeling spatial data using advanced machine-learning algorithms. Pixel-based multiple-point simulation implies the sequential modeling of individual points on the simulation grid, one at a time, by borrowing spatial information from the training image and honoring the conditioning data points. The developed methodology is based on the mapping of the training image patterns database using the t-Distributed Stochastic Neighbor Embedding (t-SNE) algorithm for dimensionality reduction, and …


Assessment For Sustainable Transportation Systems In Egypt, Hagar Mohamed Fares Jun 2024

Assessment For Sustainable Transportation Systems In Egypt, Hagar Mohamed Fares

Theses and Dissertations

The assessment of a sustainable transportation system poses a significant challenge for local governments, as it dramatically influences the promotion of environmentally friendly modes of transportation with the objective of safeguarding the public's welfare and health in their daily activities. The integration of such assessment should be implemented from the initial stages of system planning to its operational and maintenance phases, particularly in light of the increasing number of urban development activities nationwide. In order to facilitate decision-making processes, it is imperative to establish an efficient rating system that incorporates cultural and social constraints and comprehensively considers the three dimensions …


Physical Effects On The Worst-Case Delay Analysis And Signal Integrity Of Buses And Spirals, Mahmoud Mahany Jun 2024

Physical Effects On The Worst-Case Delay Analysis And Signal Integrity Of Buses And Spirals, Mahmoud Mahany

Theses and Dissertations

Physical effects have a significant impact on the IC design which will be investigated in this thesis. Moving toward advanced technology nodes, magnetic effects become more dominant than capacitive effects. As the dimensions of the devices go down and the interconnect manipulates the circuit behavior more and more. Cross talking and voltage drops are affecting the design heavily, however - going to the full electromagnetic point of view - current return path (CRP) adds significant parasitics to the performance of the chip. Neglecting the CRP gives wrong intuition and simulation of the designs, especially that the environment and surroundings can …


A Machine Learning Framework For Predicting Fabrication Hours For Industrial Steel Structure Projects, Dalia Ibrahim Jun 2024

A Machine Learning Framework For Predicting Fabrication Hours For Industrial Steel Structure Projects, Dalia Ibrahim

Theses and Dissertations

Construction projects are considered high risk projects especially due to their required large capital making them require extreme attention in estimation as overestimating a project will lead to losing bids and underestimating them will lead to incurring more costs than budgeted resulting in losses. However, estimators are often faced with very tight timelines to finish their estimates leading them to primarily rely on their experience disregarding some crucial factors resulting in inaccurate estimates. In the steel structures industry, the steel fabrication phase accounts for 30 to 40% of the overall project cost; in addition, the steel industry is labor driven; …


Electrochemical Identification Of Metal Chlorides In Eutectic Licl-Kcl Without Prior Knowledge Of Analyte Identities, Tyler Williams, Jason Torrie, Mark Schvaneveldt, Ranon Fuller, Greg Chipman, Devin Rappleye Jun 2024

Electrochemical Identification Of Metal Chlorides In Eutectic Licl-Kcl Without Prior Knowledge Of Analyte Identities, Tyler Williams, Jason Torrie, Mark Schvaneveldt, Ranon Fuller, Greg Chipman, Devin Rappleye

Faculty Publications

The identities of unknown analytes within four eutectic LiCl-KCl melts were determined using electrochemical methods, simulating the uncertainty of electrochemically probing an electrorefiner salt bath or molten salt nuclear reactor. With a variety of electrochemical methods (e.g. cyclic voltammetry, chronopotentiometry, and square-wave voltammetry), and electroanalytical techniques (e.g. semi-differentiation), every analyte was positively identified, although one false positive occurred because of an unexpected chemical interaction. This study highlights some remaining challenges for the use of electrochemical sensors in nuclear material control and accountability in molten salts: (1) quantification of analytes without the use of calibration curves (e.g. error in property values, …


An Efficient Method For Recognition Of Human-In-Motion Action Based On Foot-Lift Features, Khin Cho Tuna, Hla Myo Tunb Jun 2024

An Efficient Method For Recognition Of Human-In-Motion Action Based On Foot-Lift Features, Khin Cho Tuna, Hla Myo Tunb

ASEAN Journal on Science and Technology for Development

In the age of Industry 4.0, recognition of human moving actions becomes an essential element in smart surveillance systems at public places. The requirement of a large number of frames, view dependency and the requirement of big database are still challenging issues for human action recognition in real-time applications. This study proposes an efficient method for basic moving actions, “Walking” and “Running”, based on foot-lift features aiming at the recognition of ongoing moving action by reducing the number of frames required. The plane of moving path and foot-lift are estimated during the action by means of BLOB analysis. The performance …


Hiv3: An Efficient Beehive Monitoring System, Jack Ursillo, Aneal Kuverji, Connor Merhab, Anshuman Sahu Jun 2024

Hiv3: An Efficient Beehive Monitoring System, Jack Ursillo, Aneal Kuverji, Connor Merhab, Anshuman Sahu

Computer Science and Engineering Senior Theses

Beehive monitoring plays a major role in ensuring the health of beehives by checking for overpopulation or underpopulation within a hive. Beehive monitoring provides beekeepers with the opportunity to take action and save the hive before the problem becomes irreversible. Most solutions are too expensive for everyday beekeepers and lack elements of sustainability, making it impractical for small scale beekeepers. In this thesis, we propose a solution to this problem, demonstrating its sustainability and user-friendliness, which enables us to effectively reach a larger consumer market. We support these claims through the use of sustainable systems such as using a solar …


Enhancing Vqgan-Based Model With Connext For Blind Super-Resolution, Lebin Zhou Jun 2024

Enhancing Vqgan-Based Model With Connext For Blind Super-Resolution, Lebin Zhou

Computer Science and Engineering Master's Theses

This thesis presents a novel super-resolution model based on Vector Quantized Generative Adversarial Network (VQGAN) to enhance image resolution. Inspired by recent advancements in the field of image reconstruction, we apply VQGAN to the super-resolution task, leveraging its powerful generative capabilities to produce higher quality high-resolution images.

Building on the VQGAN framework, we propose an improved architecture that incorporates an additional ConvNeXt feature extractor based on Convolutional Neural Networks (CNN) to effectively capture and refine features from low-resolution images. To further enhance model performance, we implemented various strategies to optimize the utilization of the codebook, including capacity optimization, improved initialization, …


Finding The Shortest Path Using Dijkstra’S Algorithm, Orit D. Gruber, Deborah Sturm Jun 2024

Finding The Shortest Path Using Dijkstra’S Algorithm, Orit D. Gruber, Deborah Sturm

Open Educational Resources

This lab experiment explores an algorithm which is used to find the shortest path between two or more locations. After completing the lab, you will be able to answer the following questions in the final lab report:

  1. What is an Algorithm?
  2. What is a Graph ?
  3. What is the purpose and operation of Dijkstra’s Algorithm ?


Transforming Orthopedic Surgery: Autonomous Image-Guided Techniques For Femur Fracture Robotic Surgery, Marzieh Sadat Saeedi-Hosseiny Jun 2024

Transforming Orthopedic Surgery: Autonomous Image-Guided Techniques For Femur Fracture Robotic Surgery, Marzieh Sadat Saeedi-Hosseiny

Theses and Dissertations

Long-bone fractures, particularly femur fractures, are prevalent and necessitate surgical intervention due to traumatic forces. Manual reduction procedures pose challenges, including excessive traction forces and reliance on limited X-ray imaging, resulting in malalignment-related complications and repeated surgeries. Current methods for femur fracture reduction are prone to inaccuracies, prolonged surgical times, and postoperative complications. This research introduces image-guided methods to automate a surgical robotic system, Robossis, to enhance femur alignment accuracy, reduce procedure times, and improve patient outcomes. To address these challenges, a marker-based approach utilizing a few X-ray images is developed to detect the spatial relative position of the femur …


Design And Fabrication Of Passive Microfluidic Devices For Enhancing Membrane-Based Biosensors, Tanner N. Wells Jun 2024

Design And Fabrication Of Passive Microfluidic Devices For Enhancing Membrane-Based Biosensors, Tanner N. Wells

Theses and Dissertations

Microfluidic devices and systems have demonstrated wide applicability in sample processing and analysis. The ability to integrate sample processing and analysis into a single platform is a key benefit of microfluidic technologies. This dissertation describes the design and fabrication two types of microfluidic devices developed to enhance membrane-based biosensors. First is a device for collecting particles into a highly confined region, locally enhancing their concentration. Second is a device for size-based particle separation capable of separating differently sized particles into separate streams. Both types of devices are fabricated with a thin top layer, providing a platform for synthetic membrane-based technologies. …


The Design, Prototyping, And Validation Of A New Wearable Sensor System For Monitoring Lumbar Spinal Motion In Daily Activities, Brianna Bischoff Jun 2024

The Design, Prototyping, And Validation Of A New Wearable Sensor System For Monitoring Lumbar Spinal Motion In Daily Activities, Brianna Bischoff

Theses and Dissertations

Lower back pain is a widespread problem affecting millions worldwide, because understanding its development and effective treatment remains challenging. Current treatment success is often evaluated using patient-reported outcomes, which tend to be qualitative and subjective in nature, making objective success measurement difficult. Wearable sensors can provide quantitative measurements, thereby helping physicians improve care for countless individuals around the world. These sensors also have the potential to provide longitudinal data on daily motion patterns, aiding in monitoring the progress of treatment plans for lower back pain. In this work it was hypothesized that a new wearable sensor garment that makes use …


Ultra Low-Power, High-Performance Presence Detection System, Dante Bajarias, Cristian Medal, Jashan Kaeley Jun 2024

Ultra Low-Power, High-Performance Presence Detection System, Dante Bajarias, Cristian Medal, Jashan Kaeley

Computer Science and Engineering Senior Theses

The proliferation of Internet of Things (IoT) devices emphasizes a greater connection between humans and smart technology. From computer peripherals, personal electronics, and domestic appliances to building access management, healthcare, and security systems, modern applications are generating as much data or more than they are receiving from other sources. Human presence is a type of data that is becoming a compelling requirement for a plethora of today’s applications that must ensure seamless interactions of users with the systems and their associated services. The ultra low-power, high performance presence detection system is an accelerometer-based system capable of person detection, people counting, …


Nucleation Control System And Method Leading To Enhanced Boiling Based On Electric Cooling, Amitabh Narain, Soroush Sepahyar, Divya Kamlesh Pandya, Vibhu Vivek Jun 2024

Nucleation Control System And Method Leading To Enhanced Boiling Based On Electric Cooling, Amitabh Narain, Soroush Sepahyar, Divya Kamlesh Pandya, Vibhu Vivek

Michigan Tech Patents

A cooling module for an electric devise includes a body having formed therein a plurality of channels, a micro-structured boiling surface, a piezoelectric transducer, an inlet header, and an outlet header. Each channel of the plurality of channels is defined by a first channel surface and opposing lateral channel surfaces cooperatively defining a rectangular cross section normal to a channel axis The micro-structured boiling surface is positioned adjacent the first channel surface of each channel. The piezoelectric transducer is in acoustic communication with one of the opposing lateral channel surfaces of each channel and configured to direct acoustic waves on …


Manipulating Colloidal Particles Using Chemical Gradients And Top-Down Control, Mark Nichols Mcdonald Jun 2024

Manipulating Colloidal Particles Using Chemical Gradients And Top-Down Control, Mark Nichols Mcdonald

Theses and Dissertations

Colloidal particles provide the ideal building blocks for the next generation of microdevices, such as advanced sensors and precision drug delivery systems. However, many such applications require the use of top-down (i.e. humanly controllable) forces to manipulate colloidal particles with single-particle precision, and current methods can only achieve such precision for small numbers of particles at a time. To address this challenge, we propose using chemical forces in combination with existing top-down techniques to enable the control of larger numbers of particles simultaneously. Controlling colloids using chemical reactions is a novel technique not typically utilized. Due to its distinct difference …


Edge-Connected Microcontroller Security, Divya Syal, Gavin Ryder, Neena Ekanathan Jun 2024

Edge-Connected Microcontroller Security, Divya Syal, Gavin Ryder, Neena Ekanathan

Computer Science and Engineering Senior Theses

With a wide range of applications and the rise of cyber attacks, securing microcontrollers has become imperative; however, ensuring microcontroller performance is also crucial given how interconnected today’s systems are. This project examines the security and performance of next-generation microcontroller units leveraging new security solutions for IoT edge applications. By benchmarking these MCUs against key performance metrics, their viability will be assessed to facilitate the widespread adoption of this latest firmware.

Our research focuses on profiling the power consumption and performance of the new STM32H573 and the integrated Secure Manager, a new technology from ST Microelectronics that allows for privileged …


Autonomous Microgrid System, Xavier Kuehn, Brian Xiong Jun 2024

Autonomous Microgrid System, Xavier Kuehn, Brian Xiong

Computer Science and Engineering Senior Theses

Microgrids have made a revolutionary change in the realm of energy distribution due to the features that they offer, including localized, resilient, and sustainable energy solutions. Operating renewable resources in a microgrid while maintaining generation-load balance and acceptable voltage-frequency limits has been an open research problem. This thesis presents smart python agents for microgrid systems to automate the operations and control of microgrid renewable resources in an effort to provide resilient solutions to the intermittence issues that could potentially arise within the microgrid energy system. The smart agents operate the microgrids by not only integrating the use of renewable energy …


Uhd: Unary Processing For Lightweight And Dynamic Hyperdimensional Computing, Mehran Shoushtari Moghadam, M. Hassan Najafi Jun 2024

Uhd: Unary Processing For Lightweight And Dynamic Hyperdimensional Computing, Mehran Shoushtari Moghadam, M. Hassan Najafi

Faculty Scholarship

Hyperdimensional computing (HDC) is a novel computational paradigm that operates on long-dimensional vectors known as hypervectors. The hypervectors are constructed as long bit-streams and form the basic building blocks of HDC systems. In HDC, hypervectors are generated from scalar values without considering bit significance. HDC is efficient and robust for various data processing applications, especially computer vision tasks. To construct HDC models for vision applications, the current state-of-the-art practice utilizes two parameters for data encoding: pixel intensity and pixel position. However, the intensity and position information embedded in high-dimensional vectors are generally not generated dynamically in the HDC models. Consequently, …


Remote Vibration Based Monitoring Of Bridge Scour, Alan Kazemian Jun 2024

Remote Vibration Based Monitoring Of Bridge Scour, Alan Kazemian

Dissertations

The gradual erosion of the sediment around a bridge foundation is called Scour. This erosion is caused by water flow and increases during times of high-water flow such as flooding. The scour leaves the bridges structurally unsound over time and jeopardizes the safety of the structure. Approximately 60 percent of bridge failures in the United States are caused by scour. A variety of types of devices have been used to detect scour. Most of these devices only observe the scour and not the structural integrity of the bridge. The typical approach has relied on visual inspections of the bridges after …


Infrared Light-Based Data Association And Pose Estimation For Aircraft Landing In Urban Environments, David Akagi Jun 2024

Infrared Light-Based Data Association And Pose Estimation For Aircraft Landing In Urban Environments, David Akagi

Theses and Dissertations

In this thesis we explore an infrared light-based approach to the problem of pose estimation during aircraft landing in urban environments where GPS is unreliable or unavailable. We introduce a novel fiducial constellation composed of sparse infrared lights that incorporates projective invariant properties in its design to allow for robust recognition and association from arbitrary camera perspectives. We propose a pose estimation pipeline capable of producing high accuracy pose measurements at real-time rates from monocular infrared camera views of the fiducial constellation, and present as part of that pipeline a data association method that is able to robustly identify and …


Feasibility Of Parallelized Measurement Of Local Thermal Properties, Alexander J. Hansen Jun 2024

Feasibility Of Parallelized Measurement Of Local Thermal Properties, Alexander J. Hansen

Theses and Dissertations

This thesis documents research done in the development and the exploration of feasibility for a high-throughput method to measure local thermal properties. The present capabilities in the measurement of local thermophysical properties such as thermal conductivity, thermal diffusivity, and Kapitza resistance are very inefficient and impractical to fully understand and characterize heat transport through certain materials and features. This work follows up on past work in local thermal property measurement via the spatial domain thermoreflectance (SDTR) method, and explores the possibility of parallelizing the process. The parallelized SDTR (P-SDTR) method involves using laser projector sources to periodically heat and measure …


Design Of Precision Deployable Origami-Based Space Arrays, Clark Thomas Roubicek Jun 2024

Design Of Precision Deployable Origami-Based Space Arrays, Clark Thomas Roubicek

Theses and Dissertations

Deployable origami-based arrays can offer many benefits for a wide variety of engineering applications because of their ability to stow compactly and deploy to a large area. These types of arrays have been demonstrated for use in solar arrays, heat shields, and more; however, they have yet to be shown in high precision applications such as telescopes. The biggest roadblock to using origami in high precision arrays is align- ment in the deployed state; in optical systems, local (single panel) and global (entire array) misalignment can drastically reduce performance. Precision positioning of origami-based arrays can be a challenge because of …


Comparing Life-Cycle Dynamics Of Li-Ion Batteries (Libs) Clustered By Operating Conditions With Sindy, Kristen L. Hallas, Md Shahriar Forhad, Tamer Oraby, Benjamin Peters, Jianzhi Li Jun 2024

Comparing Life-Cycle Dynamics Of Li-Ion Batteries (Libs) Clustered By Operating Conditions With Sindy, Kristen L. Hallas, Md Shahriar Forhad, Tamer Oraby, Benjamin Peters, Jianzhi Li

Manufacturing & Industrial Engineering Faculty Publications

Lithium-ion batteries (LIBs) play a big part in the vision of a net-zero emission economy, yet it is commonly reported that only a small percentage of LIBs are recycled worldwide. An outstanding barrier to making recycling LIBs economical throughout the supply chain pertains to the uncertainty surrounding their remaining useful life (RUL). How do operating conditions impact initial useful life of the battery? We applied sparse identification of nonlinear dynamics method (SINDy) to understand the life-cycle dynamics of LIBs with respect to sensor data observed for current, voltage, internal resistance and temperature. A dataset of 124 commercial lithium iron phosphate/graphite …


Enhanced Adaptive Image-Codebook Learning For Image Reconstruction, Yutong Ge Jun 2024

Enhanced Adaptive Image-Codebook Learning For Image Reconstruction, Yutong Ge

Computer Science and Engineering Master's Theses

In the field of image reconstruction and super-resolution, using codebooks has shown promising results despite various image degradations. Previous methods either use distinct codebooks for each image category or multiple codebooks per category, with the latter achieving better performance by capturing more nuanced image features. Our research proposes a novel method that employs enhanced sets of codebooks and weight maps tailored to each image category. These weight maps dynamically combine different codebook bases to adapt to various reconstruction tasks, resulting in improved image recognition and robustness. This approach significantly enhances the expressiveness and quality of reconstructed images, making it versatile …


Preclinical Examination Of A Nerve Specific Fluorophore Using Ex Vivo Human Tissues, Logan Michael Bateman Jun 2024

Preclinical Examination Of A Nerve Specific Fluorophore Using Ex Vivo Human Tissues, Logan Michael Bateman

Dartmouth College Master’s Theses

Fluorescence-guided surgery (FGS) is a nascent field which seeks to improve patient safety and surgical outcomes using fluorescent agents known as fluorophores. Fluorophores are molecules which upon excitation with a specific wavelength of light emit a photon of a specific wavelength which can be detected using a modified camera system. Creation and translation of a fluorophore for clinical use is a costly, laborious, and time intensive process. Only a handful of fluorophores have received FDA approval and they required multiple years of tightly regulated clinical trials. Prior to these first-in-human studies these agents are subject to a litany of preclinical …