Engineering Commons^™

Cytotoxicity And Genotoxicity Of Glyphosate And Roundup Quickpro On Chinese Hamster Ovary Cells, Tasnimul Ferdous

Graduate Theses and Dissertations

Glyphosate and Roundup products have become the most used herbicide worldwide. However, previous bans in Europe and recent reversal have caused confusion over their safety. This study aims to investigate the cytotoxic and genotoxic effects of Roundup QuickPro and its main ingredient glyphosate using Chinese hamster ovary (CHO) cells. Cytotoxicity was calculated by measuring CHO cell viability with 72 hours of exposure to each toxicant. Roundup exhibited higher cytotoxicity with LC50 of 511.2 μg/mL than glyphosate’s LC50 of 3389 μg/mL. The recommended application concentration (11,233.7 μg/mL) of Roundup QuickPro is much higher than the measured LC50, which caused complete cell …

Precision And Efficacy Of Rna-Guided Dna Integration In High-Expressing Muscle Loci, Made Harumi Padmaswari, Gabrielle Bulliard, Shilpi Agrawal, Mary S. Jia, Sabin Khadgi, Kevin A. Murach, Christopher E. Nelson

Biomedical Engineering Faculty Publications and Presentations

Gene replacement therapies primarily rely on adeno-associated virus (AAV) vectors for transgene expression. However, episomal expression can decline over time due to vector loss or epigenetic silencing. CRISPR-based integration methods offer promise for long-term transgene insertion. While the development of transgene integration methods has made substantial progress, identifying optimal insertion loci remains challenging. Skeletal muscle is a promising tissue for gene replacement owing to low invasiveness of intramuscular injections, relative proportion of body mass, the multinucleated nature of muscle, and the potential for reduced adverse effects. Leveraging endogenous promoters in skeletal muscle, we evaluated two highly expressing loci using homology-independent …

Faulty Perception Correction Of Autonomous Vehicles In Real-Life Driving Scenarios, Mark Omwansa

Dissertations

Driving is one of the most popular modes of transportation in the world. The United States Department of Transportation’s (USDOT) Federal Highway Administration (FHWA) reported 2.8 trillion vehicle-miles traveled (VMT) in 2020, and the National Highway Traffic Association (NHTSA) recorded 3.2 trillion VMT in 2019. Also recorded in the NHTSA report were 39,096 fatalities and 2.7 million injuries due to traffic accidents, costing the economy an estimated $242 billion. Most of these recorded accidents can be attributed to human error or misjudgment. It is for this reason that governments and the automotive industry are looking at autonomous vehicle (AV) technologies …

Extracting Permittivity And Permeability Using The Position-Insensitive And Calibration-Independent Method On A Rectangular Waveguide, James Conrad Denemark

Theses and Dissertations

Classic methods for extracting material characteristics require known measurements to accurately calibrate the network analyzer. Previous work demonstrated a position-insensitive and calibration-independent (PiCi) transmission/reflection method to extract a material’s permittivity. This thesis proposes a method with the same function, manipulated to use one empty measurement and then two samples of different thicknesses. The PiCi method is first adopted for rectangular waveguide which resulted in inaccurate permittivity data when compared to the calibrated solution. Once detector mismatch corrections were applied, the PiCi method produced accurate results. Using a 2-D numerical root search, permittivity and permeability material characteristics are now successfully extracted …

Dual-Channel Side Channel Attack: Improved Aes Key Decryption By Combining Power And Electromagnetic Side Channels With Convolutional Neural Networks, Sean P. O'Neill

Theses and Dissertations

This research introduces a novel DL approach for SCA that combines power consumption and EM signals to enhance encryption key deduction by leveraging a dual-channel CNN architecture. A new dataset, consisting of simultaneous power and EM signal collections during 128-bitAES encryption, was developed to train and evaluate the model’s effectiveness. The combined approach achieved an 88% reduction in traces needed, from 50 traces to 6, for encryption key classification, outperforming traditional methods such as random forest, DPA, DEMA,and individual side channel CNN models. These findings highlight the potential of integrating multiple side channels in SCA to improve performance without the …

Security Of Mobile Radiological Sources: Overview Of Industry Applied Technologies, Ann M. Archer, Ashleigh Wickham

International Journal of Nuclear Security

Small radiological sources used in industrial settings recurrently require transit between job sites. Securing these sources, while stationary, can be addressed with standard security approaches and equipment. Transport of these sources increases the risk and complexity of managing and maintaining control of these sources. Implementing methodologies to securely monitor and locate sources improves response and resolution of anomalous events during transit. The Mobile Source Transit Security (MSTS) system was developed to improve security and provide situational awareness of these mobile sources throughout their job cycle. The MSTS development effort focused on creating a set of systems that could be successfully …

Organizational Factors Enabling Augmented Analytic And Bi 4.0 Implementation Success, Randy A. Williams, Gazi Murat Duman, Elif Kongar, Nasir J. Sheikh

Engineering and Technology Management Faculty Publications and Presentations

The implementation of modern Business Intelligence (BI) 4.0 and Augmented Analytics solutions is drastically influenced by organizational factors, which are widely recognized as significant drivers of success. Many researchers endeavor to understand critical success factors of BI implementation using various models, most all of which include Organizational components, along with others. Earlier studies have suggested components within the Organizational perspective play a critical role in driving overall BI implementation success. However, the research on organizational factors that focus on the advanced version of BI and augmented analytics is not well established. Addressing this need, the current work focuses on filling …

Fitting Quality Of Nmr Relaxation Data To Differentiate Asphalt Binders, Rebecca M. Herndon, Kevin Lai, Magdy Abdelrahman, Klaus Woelk

Civil, Architectural and Environmental Engineering Faculty Research & Creative Works

Asphalt binder performance grades (PGs) are important metrics in designing pavements for effective transportation infrastructure. the PG system relies on the binder's stiffness and is determined through energy- and time-intensive physical testing. Physical properties, like stiffness, can also be determined by spin–lattice NMR relaxometry, a non-destructive chemical method. NMR relaxometry can quantify the molecular mobility of materials by determining relaxation times from exponential decays of excited nuclear magnetization. While relaxation times have been used to determine physical properties of materials, a quantitative relation to the PG grades of asphalt binder is yet to be established. in this study, T1 NMR …

Assessment Of Pedestrian Safety At Roundabout Slip Lanes: A Study On Design Configurations And Surrogate Safety Measures, Norran Kakama Novat

Masters Theses

The implementation of slip lanes at roundabouts has been widely adopted to improve traffic flow and reduce vehicle conflicts. However, the presence of slip lanes introduces significant risks for pedestrians, influencing vehicle speeds, merging behaviors, and increasing the potential for pedestrian-vehicle conflicts. This study investigates pedestrian safety at roundabouts with various slip lane designs, focusing on their impact on vehicle speeds, pedestrian-vehicle conflicts, and yielding behavior. Also, the study evaluates commonly used surrogate safety measures by employing extreme value models to assess their efficiency.

The study addresses two primary objectives: (1) analyzing the effects of different slip lane configurations on …

Integrating Sustainability And Food Safety Through Quantitative Microbial Risk Assessment And Life Cycle Assessment Of Low-Moisture Foods, Jessica Bain

Graduate Theses and Dissertations

Food safety and sustainability are critical concerns in the food industry. However, these areas are often evaluated separately, leading to an incomplete understanding of the overall impact of food production on human health. This dissertation aims to integrate food safety with sustainability to provide a comprehensive assessment of the impact of low-moisture foods on human health, using the almond processing supply chain as a case study.

In addition to conducting life cycle assessments (LCA) of almond processing, wheat flour production, and dried apple processing, this dissertation aims to create a framework to bridge the gap between sustainability and food safety. …

Assessing The Critical Factors Influencing Worker Safety In Roadway Work Zones, Bahaa Chammout, Muaz O. Ahmed, Islam El-Adaway

Civil, Architectural and Environmental Engineering Faculty Research & Creative Works

Ongoing roadway construction and maintenance activities are essential for sustaining and improving infrastructure. Nonetheless, work zones in the United States continue to experience concerning frequencies of occupational and traffic accidents. Previous research highlighted multiple factors influencing work zone safety, yet their relative impact and importance remain unclear. This study addresses this gap following a multistep methodology. First, 32 safety factors were identified through an extensive literature review in a previous study. Second, a survey was administered among 298 professionals from diverse backgrounds, with an average of 17.75 years of construction experience and 13.78 years of work zone experience, to assess …

Toward Electrochemical Detection Of Salmonella Enterica Serovar Enteritidis On Hydroponically Grown Green Onions (Allium Fistulosum L.), Lisseth Casso-Hartmann

All Theses

The Food and Drug Administration (FDA) established standards during the growing, harvesting, packing, and holding of produce for human consumption as part of implementing the Food Safety Modernization Act (FSMA). One of the main requirements for farmers is to detect environmental pathogens such as Salmonella enterica species in water and sprout samples. S. enterica is a bacterium of significant concern due to its pathogenicity and ability to survive and persist in diverse environmental conditions. S. enterica has been associated with recalls in ready-to-eat foods. Traditional detection methods include Enzyme-Linked Immunosorbent Assay (ELISA), Polymerase Chain Reaction (PCR), and plate counting, which …

Comparing Conventional And Modified Cage Wheel Performance In Lowland Conditions, Rosalinda Abad, Michael Duldulao, Arthur Fajardo

The Philippine Agricultural Scientist

In agricultural production, significant cost consumption from tillage due to high energy input and low work performance may be reduced by improving the design of hand tractor components, specifically tractive devices. This study aimed to compare the field performance of conventional and modified cage wheels for hand tractors in terms of field efficiency (FE), wheel slip, and fuel consumption (FC). Using the Philippine standard methods of testing for walking-type tractors and a two-tailed t-test to analyze the data, results showed that the modified cage wheel had an FE of 90.09%, wheel slip of 7.78%, FC of 0.22 L/h, and FC …

Rehydration Kinetics Of Green Pea Grains Dried At Different Microwave Powers, Serap Kayisoglu

The Philippine Agricultural Scientist

In this study, both untreated and pre-treated green pea grain samples dried at different microwave output powers (90, 180, and 360 W) were rehydrated at three different temperatures (30ºC, 50ºC, and 70ºC). The rehydration kinetics of dried peas were analyzed using both the Peleg and the first-order kinetic models. Observations revealed that the Peleg model exhibited better agreement with the experimental data. As both microwave power and rehydration temperature increased, the rehydration capacity also increased in both pre-treated and untreated peas. The highest moisture content was observed after rehydration in pre-treated peas dried at 360 W microwave power (2.80 g …

A Novel Interpretation Of Average Run Length For Assessing The Performance Of Control Charts, Gonçalo Sousa

Masters Theses

The Average Run Length (ARL) is a performance measure of Control Charts widely used within Statistical Process Control. In this study we propose a new approach for the computation of the ARL that is based on a novel interpretation of out-of-control signals produced by a Control Chart. Specifically, out-of-control signals used to calculate traditional ARLs may correspond to Type I errors and may not reflect a Control Chart’s true performance. To compensate for this issue, for Shewhart and EWMA charts, constraints are applied to the calculation of ARLs so that only out-of-control signals that occur when the corresponding statistic is …

Introducing The Second-Order Features Adjoint Sensitivity Analysis Methodology For Neural Ordinary Differential Equations—Ii: Illustrative Application To Heat And Energy Transfer In The Nordheim–Fuchs Phenomenological Model For Reactor Safety, Dan Gabriel Cacuci

Faculty Publications

This work presents an illustrative application of the newly developed “Second-Order Features Adjoint Sensitivity Analysis Methodology for Neural Ordinary Differential Equations (2nd-FASAM-NODE)” methodology to determine most efficiently the exact expressions of the first- and second-order sensitivities of NODE decoder responses to the neural net’s underlying parameters (weights and initial conditions). The application of the 2nd-FASAM-NODE methodology will be illustrated using the Nordheim–Fuchs phenomenological model for reactor safety, which describes a short-time self-limiting power transient in a nuclear reactor system having a negative temperature coefficient in which a large amount of reactivity is suddenly inserted. The representative model responses that will …

Introducing The Second-Order Features Adjoint Sensitivity Analysis Methodology For Neural Ordinary Differential Equations—I: Mathematical Framework, Dan Gabriel Cacuci

Faculty Publications

This work introduces the mathematical framework of the novel “First-Order Features Adjoint Sensitivity Analysis Methodology for Neural Ordinary Differential Equations” (1st-FASAM-NODE). The 1st-FASAM-NODE methodology produces and computes most efficiently the exact expressions of all of the first-order sensitivities of NODE-decoder responses with respect to the parameters underlying the NODE’s decoder, hidden layers, and encoder, after having optimized the NODE-net to represent the physical system under consideration. Building on the 1st-FASAM-NODE, this work subsequently introduces the mathematical framework of the novel “Second-Order Features Adjoint Sensitivity Analysis Methodology for Neural Ordinary Differential Equations (2nd-FASAM-NODE)”. The 2nd-FASAM-NODE methodology efficiently computes the exact expressions …

Effect Of Pilot Mental Health On Passenger Willingness To Fly, Isabella L. Deloach, Sara E. Bergamini, Dowon Choi, Brooke Wheeler, Vivek Sharma

Aeronautics Student Publications

This study explored how passengers' willingness to fly is affected by the mental health condition of pilots, providing insight into public perception of the mental health condition of pilots. Results showed significant differences between all scenarios except the medication scenario vs. therapy scenario.

Patterns Of Interactions In Human-Machine Teams, Kazuhiko Momose

Theses and Dissertations

Increasingly capable machines, including Artificial Intelligence (AI) agents are playing a more important role in a wide range of applications, including human daily activities and safety-critical systems. They can benefit even more when humans and such machines agents work together as a team by leveraging each other's strengths and complementing each other to enhance overall performance. To design high-performing teams, it is critical to analyze the team dynamics and understand how humans and machines interact with each other. Collaboration, Coordination, and Cooperation (3Cs) are terms typically used to describe the behavior of teams. However, these terms tend to be used …

Modeling, Synthesis, And Experimental Characterization Of Rhenium Disulfide For Optoelectronic Devices, Solomon Opeyami Ojo

Graduate Theses and Dissertations

Two-dimensional (2D) transition metal dichalcogenides (TMDs) have garnered considerable interest for their potential in optoelectronics and photonics owing to their remarkable combination of electronic, optical, and mechanical properties. These characteristics distinguish them from other 2D materials, including graphene, making them particularly valuable for next-generation technologies. This dissertation focuses on ReS_₂, a 2D TMD with a unique anisotropic 1T distorted crystal structure. The research aims to elucidate its fundamental properties through a combination of theoretical modeling, material synthesis, and experimental characterization techniques, with the goal of optimizing ReS_₂ for device applications. A theoretical investigation utilizing Density Functional Theory …

A Low-Cost Microvascular Phantom For Photoacoustic Imaging Using Loofah, Jinhua Xu

McKelvey School of Engineering Graduate Student Theses & Dissertations

Existing photoacoustic phantoms are inadequate for mimicking the complex microvascular structures found in human tissue due to their inability to replicate varying sizes and distri- butions of vasculature. This limitation underscores the need for a new material capable of replicating intricate microvascular networks. In this thesis, we introduce loofah as a novel natural phantom material with complex fiber networks ranging from 50 to 400 μm, enabling the fabrication of phantoms with controlled optical properties comparable to those of human microvasculature.

By incorporating a controllable chromophore into the loofah material, we adjusted its ab- sorption properties to match desired specifications. The …

Ellipticity-Controlled Exceptional Points From Nanoscale Metasurfaces, Benjamin Goldberg

McKelvey School of Engineering Graduate Student Theses & Dissertations

Precise control over light polarization is critical for advancing technologies in telecommunica- tions, quantum computing, and image sensing. However, existing methods for manipulating polarization around exceptional points in non-Hermitian systems, have exclusively focused on circular polarization and work with reflected light. To address this limitation, we de- velop a novel metasurface platform with high-Q resonators that enables tunable control of polarization exceptional points across arbitrary ellipticity for transmitted light. Our design uses orthogonally polarized guided mode resonators in a two-layer silicon metasurface, where careful tuning of the dipolar guided mode resonances (DGMRs) and layer spacing allows us to control the …

Ohmic Contacts For Fabrication Of Sic Cmos Devices, Anthony Di Mauro

Graduate Theses and Dissertations

Today’s world of electronics is dominated by semiconductor devices which utilize silicon as their substrate material. Though, silicon is not ideal for semiconductor devices in high-voltage or high-temperature applications. Additionally, the efficiency of silicon devices becomes drastically reduced in nonideal operating conditions. Therefore, finding alternatives to silicon?based devices has been a topic for decades now. A few great candidates to replace silicon devices for said applications include Silicon Carbide (SiC), Gallium Nitride (GaN), and Aluminum Arsenide (AlAs). SiC has grown its reputation as the best candidate, when compared to other potential alternatives, due to its wide bandgap, high operating frequency, …

Gate Driver Design In High-Temperature Cmos Process For Heterogeneous Integration Inside Sic Power Module, Khandoker Asif Faruque

Graduate Theses and Dissertations

The shift toward electrification in transportation, including electric and hybrid vehicles, presents challenges for power electronic converters. Silicon Carbide (SiC) power devices are promising due to their high efficiency, temperature tolerance, and reduced losses compared to traditional silicon devices. However, their use is hindered by issues such as parasitic capacitances and gate inductances, which can lead to voltage spikes and stress on the device gate oxide, hence impacting converter reliability. Increasing gate resistance can help manage these issues, but it reduces switching speed and increases losses. Snubber circuits can mitigate switching stress but add extra components, reducing efficiency. Active gate …

A Cmos Ldo Voltage Regulator For Low Power Applications, Nicolaus Vail

Graduate Theses and Dissertations

This thesis presents the design, simulation, layout, and testing of a low dropout linear voltage regulator (LDO) in a 180 nm CMOS process. The LDO is intended for use in low-power, battery-operated applications, and it has an adjustable output for a variety of different implementations. It can supply up to 100 mA of current, which is enough to power many small electronic circuits. It has a dropout voltage of 150 mV, and it consumes less than 200 μA of current during operation, which is on par with many commercial regulators. The line regulation is also comparable to commercially available LDOs, …

Synthesis And Process Optimization Of Cellulose Nanocrystals From Miscanthus X. Giganteus For Commercial Viability, Jaspreet Kaur

Graduate Theses and Dissertations

Cellulose nanocrystals (CNCs), derivatives of an abundant biopolymer, i.e., cellulose, are emerging as promising alternatives to petrochemical-based products due to their unique properties, including biodegradability, low toxicity, high strength, low density, large surface area and low coefficient of expansion. CNCs have diverse applications ranging from food packaging and textiles to drug delivery and medical implants, etc. Despite their potential, the widespread commercialization of CNCs faces significant hurdles owing to the high environmental burden and production costs. They are mainly driven by the commonly used source utilized for CNC synthesis i.e., wood and the intensive synthesis process i.e., requirement of …

Reinforcement Learning-Based Optimal Control Of Uncertain Nonlinear Systems, Miguel Garcia, Wenjie Dong

Electrical and Computer Engineering Faculty Publications

This paper considers the optimal control of a second-order nonlinear system with unknown dynamics. A new reinforcement learning based approach is proposed with the aid of direct adaptive control. By the new approach actor-critic reinforcement learning algorithms are proposed with three neural network approximation. Simulation results are presented to show the effectiveness of the proposed algorithms.

Surgical Suturing Skill Assessment Using Estimated Hand Roll Angle From A Deep-Learning Computer Vision Algorithm, Jianxin Gao, Amir Mehdi Shayan, Simar P. Singh, Joe Bible, Ravikiran Singapogu, Richard E. Groff

Publications

This paper proposes a deep-learning computer vision algorithm to estimate hand roll angles for metric-based assessment of surgical suturing skills. The number of rolls metric, previously calculated directly from IMU data, counts the number of hand roll reversals during a single suture. To calculate this metric using computer vision, we apply a deep-learning algorithm that can reliably estimate hand roll angles after training on suturing videos collected on the SutureCoach simulator. Results show that the estimation accuracy of the deep-learning algorithm is robust to different video backgrounds. The number of rolls metrics were used to analyze suturing performance in the …

Thermal Conductivity Characterization Of High Oleic Vegetable Oils Based Hybrid Nanofluids Formulated Using Gnp, Tio2, Mos2, Al2o3 Nanoparticles For Mql Machining, Anthony Chukwujekwu Okafor, Tobechukwu Kingsley Abor, Saidanvar Esanjonovich Valiev, Ignatius Echezona Ekengwu, Abiodun Saka, Monday Uchenna Okoronkwo

Mechanical and Aerospace Engineering Faculty Research & Creative Works

This paper presents the results of thermal conductivity characterization of six high oleic soybean oil (HOSO) and four high oleic canola oil (HOCO)-based hybrid nanofluids formulated with four types of nanoparticles (Graphene nanoplatelet (xGnP), TiO2, MoS2, and Al2O3) at nanoparticles wt.% concentration from 1 % to 7 % in 1 % increment using the two-step method for use in MQL machining of difficult-to-cut metals. Thermal conductivity of the formulated hybrid nanofluids were measured using Thermtest Transient Hot Wire Liquid Thermal Conductivity Meter at temperatures from 25 °C to 75 °C in increment of 10 °C. Obtained results showed that thermal …

Breaking The Procrastination Barrier, Bianca Ebanks

Theses and Dissertations

Procrastination is a common barrier to productivity, impacting individuals' ability to achieve goals, especially in academic and professional settings. This study investigates a mixed-methods online intervention combining Behavioral Analysis (BA) principles with mindfulness exercises to reduce procrastination. The aim was to develop a human-centered, personalized intervention that utilizes behavioral reminders and mindfulness techniques to address procrastination in 43 participants. Participants' procrastination levels were assessed using the Irrational Procrastination Scale (IPS), and interventions were tailored based on individual procrastination tendencies. Reminders were sent via email or text, with timing adjusted to participants’ specific needs. The intervention also included mindfulness exercises designed …