8-Hydroxy-2'-Deoxyguanosine As A Biomarker Of Oxidative Stress In Acute Exacerbation Of Chronic Obstructive Pulmonary Disease,
2019
TÜBİTAK
8-Hydroxy-2'-Deoxyguanosine As A Biomarker Of Oxidative Stress In Acute Exacerbation Of Chronic Obstructive Pulmonary Disease, Xing Liu, Kaili Deng, Sixia Chen, Yunshi Zhang, Jing Yao, Xiaoqin Weng, Yang Zhang, Tianming Gao, Ganzhu Feng
Turkish Journal of Medical Sciences
8-Hydroxy-2'-deoxyguanosine (8-OHdG) is a biomarker of oxidative stress and has been implicated in many diseases. The aim of this study was to investigate the clinical value of plasma 8-OHdG level in patients with acute exacerbation of chronic obstructive pulmonary disease (AECOPD).Materials and methods: A total of 154 subjects were enrolled in this study, including 20 healthy volunteers, 24 COPD patients in the stable phase, and 110 AECOPD patients. Peripheral blood samples, demographic information, and clinical characteristics were collected from all subjects at the time of being recruited into the study. Plasma 8-OHdG level was detected by enzyme-linked immunosorbent assay.Results: 8-OHdG …
Serum Adropin Levels In Psoriasis Vulgaris And Its Relation With Metabolic Parameters,
2019
TÜBİTAK
Serum Adropin Levels In Psoriasis Vulgaris And Its Relation With Metabolic Parameters, Selma Korkmaz, Gülben Sayilan Özgün
Turkish Journal of Medical Sciences
Adropin is a peptide-structure hormone that plays a role in preventing the development of insulin resistance, which has been linked to obesity and metabolic regulation. The purpose of this study is to assess serum adropin levels and their relationship with metabolic parameters in psoriasis vulgaris patients both with and without metabolic syndrome (MetS).Materials and methods: Fifty-three patients and 26 healthy controls were included in this study. Serum adropin levels, fasting blood glucose, fasting serum insulin, high-density lipoprotein cholesterol, low-density lipoprotein cholesterol, total cholesterol, and triglyceride levels of all participants were analyzed. Enzyme-linked immunosorbent assay was used to measure serum adropin …
Ischemic Modified Albumin As A New Biomarker In Predicting Oxidative Stress In Alopecia Areata,
2019
TÜBİTAK
Ischemic Modified Albumin As A New Biomarker In Predicting Oxidative Stress In Alopecia Areata, Hati̇ce Ataş, Müzeyyen Gönül, Yasi̇n Öztürk, Mustafa Kavutçu
Turkish Journal of Medical Sciences
Results show that oxidative stress is a pathophysiologic factor for alopecia areata (AA); however, the markers used can be confounding. Thus, we aimed to investigate the role of oxidative stress in the pathogenesis of AA through an evaluation of ischemia-modified albumin (IMA); other markers of the oxidant/antioxidant system, such as SOD, CAT, GSH-ST, and MDA; and contributing clinical risk factors. Materials and methods: The usefulness of IMA as a new marker for oxidative stress was compared with that of other markers and evaluated in patients with AA.Results: The mean serum level of IMA was of higher statistical significance in AA …
8-Armed Octopus: Evaluation Of Clinicopathologic Prognostic Factors Of Urothelial Carcinoma Of The Upper Urinary System,
2019
TÜBİTAK
8-Armed Octopus: Evaluation Of Clinicopathologic Prognostic Factors Of Urothelial Carcinoma Of The Upper Urinary System, Sümeyye Ekmekci̇, Ülkü Küçük, Yelda Dere, İzzeti̇ye Ebru Çakir, Hati̇ce Ceren Sayar, Batuhan Ergani̇, Özgür Çakmak, Ozan Bozkurt, Kutsal Yörükoğlu
Turkish Journal of Medical Sciences
This study was designed to determine the characteristic features of upper urinary system urothelial carcinomas (UUSUCs) and to evaluate the clinicopathological parameters associated with prognosis.Materials and methods: A total of 74 cases of UUSUC were included, from three different centers. Demographic data and histopathological features such as tumor localization, concomitant tumor in the urinary system, distant metastasis with overall survival and disease-free survival obtained from the hospital records were evaluated retrospectively. Histopathologic prognostic features such as grade, perineural invasion, lymphovascular invasion, tumor necrosis, and surgical margin status were also evaluated.Results: Seventy cases (94.6%) underwent open nephroureterectomy whereas 4 cases (5.4%) …
Comparison Of Conventional And Modern Methods In Determining Ischemic Stroke Etiology By General And Stroke Neurologists,
2019
TÜBİTAK
Comparison Of Conventional And Modern Methods In Determining Ischemic Stroke Etiology By General And Stroke Neurologists, Refi̇k Kunt, Mustafa Kürşad Kutluk, Bedi̇le İrem Ti̇fti̇kci̇oğlu, Nazi̇re Efser Yeşi̇m Afşar Fak, Ali̇ Kemal Erdemoğlu, Muhteşem Gedi̇zli̇oğlu, Vesi̇le Öztürk
Turkish Journal of Medical Sciences
This study aimed to investigate the consistency between stroke and general neurologists in subtype assignment using the Trial of ORG-10172 in Acute Stroke Treatment (TOAST) and Causative Classification of Stroke (CCS) systems.Materials and methods: Fifty consecutive acute ischemic stroke patients admitted to the stroke unit were recruited. Patients were classified by two stroke and two general neurologists, each from different medical centers, according to TOAST followed by the CCS. Each neurologist was assessed for consistency and compliance in pairs. Concordance among all four neurologists was investigated and evaluated using the kappa (ĸ) value.Results: The kappa (ĸ) value of diagnostic compliance …
Validity And Reliability Of The Amsterdam Preoperative Anxiety And Information Scale In The Turkish Population,
2019
TÜBİTAK
Validity And Reliability Of The Amsterdam Preoperative Anxiety And Information Scale In The Turkish Population, Funda Çeti̇nkaya, Esi̇n Kavuran, Kevser Sevgi̇ Ünal Aslan
Turkish Journal of Medical Sciences
This study aimed to adapt the Amsterdam Preoperative Anxiety and Information Scale (APAIS) to measure the preoperative anxiety of adult Turkish patients undergoing surgery.Materials and methods: The sample of this methodological study included 210 patients. Data were collected by using personal information forms, the APAIS, and the State Anxiety Scale (STAI). Cronbach's ∝-coefficient was calculated, and test-retest reliability was tested. Results: Cronbach's ∝-coefficients of the APAIS anxiety and information requirement subscales were 0.897 and 0.786, respectively. The mean test and retest scores of the APAIS were not different. The test and retest scores of the patients were significantly, positively, and …
Role Of Iliac Crest Tangent In Correct Numbering Of Lumbosacral Transitional Vertebrae,
2019
TÜBİTAK
Role Of Iliac Crest Tangent In Correct Numbering Of Lumbosacral Transitional Vertebrae, Nesri̇n Gündüz, Gülci̇n Durukan Günaydin, Mehmet Bi̇lgi̇n Eser, Ahmet Aslan, Adnan Kabaali̇oğlu
Turkish Journal of Medical Sciences
The iliac crest tangent (ICT) has recently emerged as a reliable landmark to correctly number the lumbosacral transitional vertebrae (LSTV). We retrospectively evaluated the reproducibility and accuracy of the ICT as a landmark in subjects without disc degeneration.Materials and methods: Fifty-eight patients with LSTV [19 female, 41 (26-52) years] and 55 controls without LSTV [23 female, 40 (26-55) years] who had undergone spinal computed tomography were included. The ICT was drawn on the coronal images, with the cursor in the sagittal view set to the posterior ⅓ of the vertebral body located one level above the LSTV. When more than …
Iron Supplementation Should Be Given In Breath-Holding Spells Regardless Of Anemia,
2019
TÜBİTAK
Iron Supplementation Should Be Given In Breath-Holding Spells Regardless Of Anemia, Gürkan Gürbüz, Peren Perk Yücel, Turgay Çokyaman, Özge Berfu Gürbüz
Turkish Journal of Medical Sciences
The purpose of this retrospective study was to determine the effectiveness of oral iron therapy in breath-holding spells and evaluation of electrocardiographical changes.Materials and methods: Three hundred twelve children aged 1-48 months and diagnosed with breath-holding spells between January 2017 and April 2018 were included. Patients' laboratory findings were compared with 100 patients who had one simple febrile seizure.Results: Cyanotic breath-holding spells were diagnosed in 85.3% (n = 266) of patients, pallid spells in 5.1% (n = 16), and mixed-type spells in 9.6% (n = 30). Sleep electroencephalograms were applied for all patients, 98.2% (n = 306) of which were …
Percutaneous Plasma Laser Disc Coagulation And Navigable Ablation Decompression In The Treatment Of Cervical Disc Herniation: A Single Center Experience, Ayşegül Ceylan, İbrahi̇m Aşik
Turkish Journal of Medical Sciences
Background/aim: We aimed to compare the effectivity of percutaneous disc coagulation therapy (PDCT) and navigable ablation decompression treatment (L-DISQ) in patients who were diagnosed with cervical disc herniation. Materials and methods: Visual analog scale (VAS) and Neck Pain Index (NPI) scores were recorded initially and at the 1st, 3rd, 6th, and 12th months after the procedures. Patient Satisfaction Scale (PSS) scores were recorded 12 months after the procedures.Results: Mean VAS scores were 7.55 and 3.1 points in the PDCT group and 7.6 and 3.00 points in the L-DISQ group; mean NPI scores were 34.2 and 20.75 points in the PDCT …
Evaluation Of The Retinal Nerve Fiber Layer And Ganglion Cell Complex Thicknesses In Patients With Exfoliation Syndrome,
2019
TÜBİTAK
Evaluation Of The Retinal Nerve Fiber Layer And Ganglion Cell Complex Thicknesses In Patients With Exfoliation Syndrome, Cem Alay, Oya Tekeli̇, Özge Yanik Odabaş, Feyza Çaliş Karanfi̇l
Turkish Journal of Medical Sciences
Background/aim: This study aimed to evaluate retinal nerve fiber layer (RNFL) and ganglion cell complex (GCC) thicknesses using spectral domain optical coherence tomography (SD-OCT) in both unilateral and bilateral exfoliation syndrome (XFS) patients.Materials and methods: Twenty-four patients with unilateral XFS, 20 patients with bilateral XFS, and 23 healthy subjects were enrolled in this study. Eyes with XFS were compared with both fellow eyes and age-matched control subject eyes in terms of mean and segmental RNFL thickness and minimum, mean, and segmental GCC thickness. Results: In the bilateral XFS group, minimum GCC of the right eye (75.80 ± 11.6 μm) was …
Prevalence Of Multiple Sclerosis In An Urban Population Of Sivas Province In Turkey,
2019
TÜBİTAK
Prevalence Of Multiple Sclerosis In An Urban Population Of Sivas Province In Turkey, Şeyda Fi̇gül Gökçe, Burhanetti̇n Çi̇ğdem, Sanem Nemmezi̇ Karaca, Asli Bolayir, Özlem Kayim Yildiz, Ahmet Suat Topaktaş, Hati̇ce Balaban
Turkish Journal of Medical Sciences
Background/aim: Multiple sclerosis (MS) is a common neurological disorder that can be a leading cause of nontraumatic disability in several countries. Recent reports have indicated a moderate to high risk of MS in European countries. In this study, we examined the prevalence of MS in a well-defined urban population of provincial center in Sivas Province in Turkey.Materials and methods: This study sampled all registered residents of urban areas of provincial center in Sivas Province in April 2017 and 2018 January. All the included patients met the McDonald 2010 criteria. Medical records were reviewed, including all available previously acquired magnetic resonance …
Comparison Of Ga-68 Psma Positron Emission Tomography/Computerized Tomography With Tc-99m Mdp Bone Scan In Prostate Cancer Patients, Rabi̇a Lebri̇z Uslu Beşli̇, Muhammet Sai̇t Sağer, Eli̇fe Akgün, Sertaç Asa, Onur Erdem Şahi̇n, Çeti̇n Demi̇rdağ, Ekrem Güner, Seyedbaresh Razavi̇khosroshahi̇, Emre Karayel, Hüseyi̇n Pehli̇vanoğlu, Aslan Aygün, İlhami̇ Uslu, Zübeyr Talat, Keri̇m Sönmezoğlu
Turkish Journal of Medical Sciences
Background/aim: The aim of our study was to compare Tc-99m MDP bone scan and Ga-68 PSMA PET/CT in terms of detection of bone metastasis in prostate cancer patients. Materials and methods: A total of 28 prostate cancer patients with bone scan and PSMA PET/CT performed within 90 days were retrospectively included in our analysis. All bone lesions were scored as negative (score-0), positive (score-1), or suspicious (score-2) for metastasis by two experienced nuclear medicine physicians. Both patient-based and region-based analyses were made for all osseous lesions. Results: On per-patient analysis; sensitivity, specificity, positive predictive value (PPV), negative predictive value (NPV), …
In Silico Design And In Vitro Development Of A Highly Accurate Test To Detect Brucella Species,
2019
TÜBİTAK
In Silico Design And In Vitro Development Of A Highly Accurate Test To Detect Brucella Species, Hosein Safari, Setareh Shahnazari, Maysam Mard-Soltani, Somayeh Tavakoli, Bahman Khalesi
Turkish Journal of Medical Sciences
Background: Conventionalmethods of detecting Brucella spp. suffer from technical and biological complications. Besides, newly characterized species of the genus Brucella could be neglected by previously designed polymerase chain reaction (PCR) tests. Therefore, a more accurate PCR-based test seems to be imminently needed. Materials and methods: Blood samples were collected from 39 patients diagnosed with brucellosis and 25 healthy controls. Multiple sequence alignments (MSA) were performed on 500 Omp2-related protein and gene sequences. Thereafter, specific primers were designed and synthesized for the regions with highest conservancy. The collected samples were assessed by PCR test. To overcome the cross-reactivity issue, PCR thermal …
Antinociceptive Effect Of Liposomal Bupivacaine Formulations After Intrathecal Administration In Rats,
2019
TÜBİTAK
Antinociceptive Effect Of Liposomal Bupivacaine Formulations After Intrathecal Administration In Rats, İlker Yi̇ği̇t, Berri̇n Günaydin, Ömer Hakan Emmez, Meci̇t Orhan Uludağ, Nur Banu Bal, İsmai̇l Tuncer Deği̇m
Turkish Journal of Medical Sciences
Background/aim: Based on our previous in vitro study with multilamellar liposomal bupivacaine (MLB) versus bupivacaine alone in artificial cerebrospinal fluid, we aimed to investigate in vivo antinociceptive effect of intrathecal MLB by determining tail flick latency (TFL) time after thermal stimulation in rats. Materials and methods: After preparing MLB and high-yield drug entrapment in liposome (HYDEL) bupivacaine, 18 female Wistar rats were assigned to 3 groups as control (bupivacaine) and study groups (MLB and HYDEL bupivacaine) including 6 rats in each group to administer these drugs intrathecally. Antinociceptive activity was determined in terms of TFL time after thermal stimulation. Maximum …
A Comparative Biomechanical Analysis Of Suprapectineal And Infrapectineal Fixation On Acetabular Anterior Column Fracture By Finite Element Modeling, Mehmet Yücens, Kadi̇r Bahadir Alemdaroğlu, Ahmet Özmeri̇ç, Serkan İltar, Ahmet Özgür Yildirim, Nevres Hürri̇yet Aydoğan
Turkish Journal of Medical Sciences
Background/aim: The aim of this study is to compare the stability and implant stresses of suprapectineal plate with infrapectineal plate in three subconfigurations of the screw types. Materials and methods: The stabilities of different fixation methods were compared by finite element analysis on six models. Three infrapectineal and three suprapectineal models each with locked, unlocked, or combined screws were employed. Three-dimensional finite element stress analysis was performed by using isotropic materials with a load of 2.3 kN applied at standing positions. Motion at the fracture line was measured on four different points located on the pubic and iliac sides of …
Tenofovir Disoproxil Fumarate May Not Cause Renal And Bone Toxicity In Chronic Hepatitis B Patients: A Retrospective Cross-Sectional Study, Hati̇ce Rahmet Güner, Zeli̇ha Koçak Tufan, Gülruhsar Yilmaz, Mehmet Akin Taşyaran
Turkish Journal of Medical Sciences
No abstract provided.
Efficiency Of Pulsed Electromagnetic Fields On Pain, Disability, Anxiety, Depression, And Quality Of Life In Patients With Cervical Disc Herniation: A Randomized Controlled Study, Erkam Hattapoğlu, İbrahi̇m Batmaz, Banu Di̇lek, Mehmet Karakoç, Serda Em, Remzi̇ Çevi̇k
Turkish Journal of Medical Sciences
Background/aim: In this study, it was aimed to investigate the effects ofpulsed electromagnetic field(PEMF) therapy on pain, disability, psychological state, and quality of life in cervical disc herniation.Materials and methods: Patients were randomly divided into two groups, including Group 1, which received a therapy consisting of transcutaneous electrical nerve stimulation (TENS), hot pack (HP), and PEMF, and Group 2, which received a magnetic field (sham magnetic field) without current flow in addition to TENS and HP therapy. Pain was assessed by a visual analog scale (VAS, 0?10 cm). The other outcome measures were function (Neck Pain and Disability Scale), anxiety-depressive …
Additional Effects Of Erythropoietin Pretreatment, Ischemic Preconditioning, And N-Acetylcysteine Posttreatment In Rat Kidney Reperfusion Injury, Mohammed Elshiekh, Mehri Kadkhodaee, Behjat Seifi, Mina Ranjbaran
Turkish Journal of Medical Sciences
Background/aim: Since the nature of ischemia/reperfusion (IR)-induced tissue damage is multifactorial and complex, in the current study, the effects of multiple treatment strategies via concomitant administration of erythropoietin (EPO) and N-acetylcysteine (NAC) with an ischemic preconditioning (IPC) regimen on renal IR injury were examined.Materials and methods: Thirty male Wistar rats were subjected to bilateral occlusion of the renal pedicles for 50 min followed by reperfusion. EPO (1000 IU/kg) was administered for 3 days, as well as IPC before the IR and NAC (150 mg/kg) administration for 4 days after IR. The animals were randomly allocated into 6 groups (n = …
Does Smoking Increase The Anesthetic Requirement?,
2019
TÜBİTAK
Does Smoking Increase The Anesthetic Requirement?, Erdoğan Öztürk, Mustafa Sai̇d Aydoğan, Kazim Karaaslan, Zafer Doğan, Ufuk Topuz
Turkish Journal of Medical Sciences
Background/aim:To examine the effects of active and passive smoking on perioperative anesthetic and analgesic consumption. Materials and methods: Patients were divided into three groups: group S, smokers; group PS, passive smokers; and group NS, individuals who did not have a history of smoking and were not exposed to smoke. All patients underwent the standard total intravenous anesthesia method. The primary endpoint of this study was determination of the total amount of propofol and remifentanil consumed. Results: The amount of propofol used in induction of anesthesia was significantly higher in group S compared to groups PS and NS. Moreover, the total …
Alterations In Serum Levels Of Copper, Zinc, And Selenium Among Children With Sickle Cell Anemia,
2019
TÜBİTAK
Alterations In Serum Levels Of Copper, Zinc, And Selenium Among Children With Sickle Cell Anemia, Rana Hasanato
Turkish Journal of Medical Sciences
Background/aim: Oxidative stress contributes to pathophysiological dysfunction in sickle cell anemia (SCA). Copper (Cu) is a prooxidant, whereas zinc (Zn) and selenium (Se) are antioxidant trace elements. This study investigates the serum levels of Cu, Zn, and Se among children with SCA.Materials and methods: This cross-sectional study was performed at King Khalid University Hospital, Riyadh. Thirty-three children with SCA in steady state and 33 age- and sex-matched normal healthy children were included in the study. Cu, Zn, and Se levels were measured by inductively coupled plasma-mass spectrometry (ICP-MS) instrument.Results: The median serum Cu levels among SCA patients (1.3 -g/mL) were …
