Cross-Cultural Adaptation, Reliability And Validity Of The Turkish Version Of Patient-Specific Functional Scale In Patients With Chronic Neck Pain, Gamze Yalçinkaya, Bi̇lge Kara, Mehmet Nuri̇ Arda
Turkish Journal of Medical Sciences
Background/aim: Current clinical guidelines recommend to use both clinical and self-reported measurements for evaluation of chronic neck pain. Among the self-reported outcomes, Neck disability index and patient-specific functional scale are the most widely used and recommended instruments. The purpose of our study was to determine the test-retest reliability and validity of patient-specific functional scale which was not validated in Turkish language previously. Materials and methods: Translation and adaptation process had conducted according to the Beaton et al. Sociodemographic data, Turkish version of patient-specific functional scale and neck disability index were recorded at the initial assessment. Retest assessment was produced for …
Effects Of Different Analgesic Methods Used For Vaginal Delivery On Mothers And Fetuses,
2020
TÜBİTAK
Effects Of Different Analgesic Methods Used For Vaginal Delivery On Mothers And Fetuses, Gülçi̇n Babaoğlu, Banu Kiliçaslan, Aysun Ankay Yilbaş, Bi̇lge Çelebi̇oğlu
Turkish Journal of Medical Sciences
Background/aim: Knowledge regarding pain relief during labor remains insufficient. We aimed to determine and compare the effectiveness and safety of epidural analgesia, combined spinal-epidural analgesia, and parenteral meperidine on both mothers and fetuses. Materials and methods: This study was designed as an observational case-control study. We collected prospective data from patients whose labor pain management was conducted with meperidine in addition to retrospective cohort data of neuraxial methods; 138 patients were enrolled. Epidural analgesia group consisted of 68 patients, whereas combined spinal-epidural (CSE) analgesia group and meperidine group consisted of 50 and 20 patients, respectively. We compared the delivery patterns, …
Psychometric Evaluation Of The Persian Version Of The Doloplus-2 (P-Doloplus-2) Scale In Elderly With Dementia,
2020
TÜBİTAK
Psychometric Evaluation Of The Persian Version Of The Doloplus-2 (P-Doloplus-2) Scale In Elderly With Dementia, Mohammad Zare, Zahra Tagharrobi, Khadijeh Sharifi, Zahra Sooki, Javad Abolhasani
Turkish Journal of Medical Sciences
Background/aim: A scale for behavioural pain assessment is useful for the detection and determination of pain in the elderly with dementia. This study aimed to translate and evaluate the psychometric properties of Doloplus-2 in the elderly with dementia in Iran. Materials and methods: In this methodological study, after translation and evaluating the face and content validity of Doloplus-2, 100 elderly people were selected by the convenience sampling method in Kashan, 2018-2019. Exploratory factor analysis, convergent validity, and known-groups comparison were applied to determine construct validity. Reliability was also assessed through internal consistency, equivalence, and stability methods were used. The ceiling …
Neurotrophic Factors In Bipolar Disorders Patients With Manic Episode,
2020
TÜBİTAK
Neurotrophic Factors In Bipolar Disorders Patients With Manic Episode, Özgür Korhan Tunçel, Gökhan Sarisoy, Eda Çeti̇n, Ebru Kaynar Tunçel, Bi̇rşen Bi̇lgi̇ci̇, Arzu Karaustaoğlu
Turkish Journal of Medical Sciences
Background/aim: Neurotrophins are one of the most important molecule groups affecting cerebral neuroplasticity. The amount of evidence about the role of changes in neuroplasticity in the pathophysiology of bipolar disease is growing. Materials and methods: We measured serum levels of brain-derived neurotrophic factor (BDNF), nerve growth factor (NGF), neurotrophin-3 (NT-3), glial cell-line derived neurotrophic factor (GDNF), vascular endothelial growth factor (VEGF), insulin-like growth factor-1 (IGF-1), fibroblast growth factor (FGF)-2, neuritin 1 (Nrn 1) in bipolar 1 manic episode patients (n = 45) and healthy control group. Results: When controlled for age, BMI and cortisol, it was found that the serum …
The Relationship Of The Immune Response Mediator Genes' Polymorphic Variants With The Methotrexate Efficacy In Juvenile Idiopathic Arthritis, Liliia Nazarova, Ksenia Danilko, Viktor Malievsky, Denis Karimov, Akhat Bakirov, Tatiana Viktorova
Turkish Journal of Medical Sciences
Background/aim: The aim of the study was to analyze the relationship of the immune response mediator genes' polymorphic loci (TNFA rs1800629, LTA rs909253, IL1B rs16944, IL2-IL21 rs6822844, IL2RA rs2104286, IL6 rs1800795, IL10 rs1800872, MIF rs755622, CTLA4 rs3087243, NFKB1 rs28362491, PTPN22 rs2476601, PADI4 rs2240336) variants with the methotrexate efficacy in juvenile idiopathic arthritis (JIA). Materials and methods: The study included 274 JIA patients from the Republic of Bashkortostan, Russia. Achieving the American College of Rheumatology Pediatric 30 (ACR Pedi 30) response was regarded as the presence of the response to methotrexate (otherwise, as the absence), while achieving clinical remission on medication …
Ocular Toxicity Of Intravitreal Golimumab In A Rabbit Model,
2020
TÜBİTAK
Ocular Toxicity Of Intravitreal Golimumab In A Rabbit Model, Ceren Durmaz Engi̇n, Serap Ci̇laker Miçili, Osman Yilmaz, Hüsnü Alper Bağriyanik, Beki̇r Uğur Ergür, Fatoş Önen, Ali̇ Osman Saatci̇
Turkish Journal of Medical Sciences
Background/aim: To investigate the effect of intravitreal golimumab on rabbit retina histopathology. Materials and methods: Sixteen albino New Zealand rabbits were divided into three groups. The right eye of each rabbit in groups I, II, and III received a single intravitreal injection of 5 mg/0.05 mL (6 eyes), 10 mg/0.1 mL (6 eyes), or 20 mg/0.2 mL (4 eyes) golimumab, while left eyes served as controls with the same volume of a balanced salt solution injection. All animals were examined using slit-lamp biomicroscopy and indirect ophthalmoscopy before and after intravitreal injection and at days 1 and 7. Animals were euthanized …
Importance Of The National Early Warning Score (News) At The Time Of Discharge From The Intensive Care Unit,
2020
TÜBİTAK
Importance Of The National Early Warning Score (News) At The Time Of Discharge From The Intensive Care Unit, Ci̇hangi̇r Doğu, Güvenç Doğan, Selçuk Kayir, Özgür Yağan
Turkish Journal of Medical Sciences
Backround/aim: To identify, at an early stage of intensive care, patients who will require readmission to the intensive care unit (ICU) based on their National Early Warning Score (NEWS-d) at discharge.Materials and methods: Overall, 536 patients aged >18 years who stayed at a tertiary ICU for >24 h were included. Patients who readmitted and not readmitted to the intensive care within 48 h after discharge were compared.Results: Mean patient age was 64.26 ± 18.50 years and 252 (44.7%) patients were male. Mean Acute Physiology and Chronic Health Evaluation II (APACHE II) score was 21.86 ± 8.74; mean NEWS-d was 4.48 …
Histopathological And Mechanical Effects Of Ankaferd Blood Stopper® On Wound Healing In Rats: An Experimental Model,
2020
TÜBİTAK
Histopathological And Mechanical Effects Of Ankaferd Blood Stopper® On Wound Healing In Rats: An Experimental Model, Sertaç Hancioğlu, Berat Di̇lek Demi̇rel, Ünal Biçakci, Seda Gün, Mehmet Ender Aritürk, Nurşen Aritürk
Turkish Journal of Medical Sciences
Background/aim: To evaluate the histopathological and mechanical effects of Ankaferd Blood Stopper (ABS) application on wound healing.Materials and methods: A total of 24 Wistar albino rats were randomly divided into three equal groups. In each group, a 3 cm-long midline vertical skin incision was performed in the back of the rats. In Group 1, the incision was sutured primarily. In Group 2, incision was left to secondary healing. In Group 3, ABS was applied to the incision. On the 10th day, burst pressure width was measured, and rats were sacrificed. The tissue samples were examined histopathologically. Statistical analysis was conducted …
Melatonin, Aging, And Covid-19: Could Melatonin Be Beneficial For Covid-19 Treatment In The Elderly?,
2020
TÜBİTAK
Melatonin, Aging, And Covid-19: Could Melatonin Be Beneficial For Covid-19 Treatment In The Elderly?, Güler Öztürk, Kazi̇me Gonca Akbulut, Şevi̇n Güney
Turkish Journal of Medical Sciences
The aim of this review is to summarize current studies on the relationship between melatonin and aging. Nowadays, age-related diseases come into prominence, and identifying age-related changes and developing proper therapeutic approaches are counted as some of the major issues regarding community health. Melatonin is the main hormone of the pineal gland. Melatonin is known to influence many biological processes in the body, including circadian rhythms, the immune system, and neuroendocrine and cardiovascular functions. Melatonin rhythms also reflect the biological process of aging. Aging is an extremely complex and multifactorial process. Melatonin levels decline considerably with aging and its decline …
Melatonin Attenuates Ovarian Ischemia Reperfusion Injury In Rats By Decreasing Oxidative Stress Index And Peroxynitrite,
2020
TÜBİTAK
Melatonin Attenuates Ovarian Ischemia Reperfusion Injury In Rats By Decreasing Oxidative Stress Index And Peroxynitrite, Şenol Kalyoncu, Bülent Yilmaz, Mustafa Demi̇r, Meltem Tuncer, Zehra Bozdağ, Onur Ince, Mehmet Aki̇f Bozdayi, Hasan Ulusal, Seyi̇than Taysi
Turkish Journal of Medical Sciences
Background/aim: To evaluate the protective effect of melatonin on ovarian ischemia reperfusion injury in a rat model. Materials and methods: Forty-eight rats were separated equally into 6 groups. Group 1: sham; Group 2: surgical control with 3-h bilateral ovarian torsion and detorsion; Group 3: intraperitoneal 5% ethanol (1 mL) just after detorsion (as melatonin was dissolved in ethanol); Group 4: 10 mg/kg intraperitoneal melatonin 30 min before 3-h torsion; Group 5:10 mg/kg intraperitoneal melatonin just after detorsion; Group 6:10 mg/kg intraperitoneal melatonin 30 min before torsion and just after detorsion. Both ovaries and blood samples were obtained 7 days after …
Comparison Of Ischemic Preconditioning And Botulinuma Toxin Injection For The Prevention Of Ischemia-Reperfusion Injury In Musculocutaneous Flaps, Handan Derebaşinlioğlu, Anil Demi̇röz, Yağmur Aydin, Hakan Ekmekçi̇, Özlem Balci Ekmekçi̇, Övgü Aydin, Levent Cankorkmaz
Turkish Journal of Medical Sciences
Background/aim: The aim of the study was to evaluate the protective effect of Botulinum A toxin injection against ischemia-reperfusion injury. Materials and methods: Thirty-two Sprague-Dawley rats were divided into: control, ischemia-reperfusion, ischemic preconditioning, and botulinum groups. In all groups the musculocutaneous pedicle flap was occluded for 4 h, and then reperfused to induce ischemia- reperfusion injury. Serum and tissue myeloperoxidase (MPO) and nitric oxide (NO) levels were measured at 24 h and at 10 days. Results: Tissue MPO levels did not differ significantly between the ischemic preconditioning and botulinum groups at 24 h but was significantly lower in the botulinum …
Diagnostic Approach In Parenchymal Lung Diseases: Transbronchial Lung Biopsy Or Cryobiopsy?,
2020
TÜBİTAK
Diagnostic Approach In Parenchymal Lung Diseases: Transbronchial Lung Biopsy Or Cryobiopsy?, Ali̇ Kadri̇ Çirak, Nuran Katgi, Onur Fevzi̇ Erer, Pinar Çi̇men, Fatma Fevzi̇ye Tuksavul, Burçi̇n Hakoğlu
Turkish Journal of Medical Sciences
Background/aim: Diagnosis of interstitial lung diseases requires a multidisciplinary approach, and a gold standard for histological diagnosis is open lung biopsy. Transbronchial lung biopsy (TBLB) and in recent years an alternative method, cryobiopsy (TBLC), are used for the diagnosis of parenchymal lung lesions. The aim of this study is to compare the efficacy of concomitant conventional TBLB and TBLC. Materials and methods: A total of 82 patients who underwent TBLC for diagnosis of diffuse parenchymal lung diseases at Dr. Suat Seren Chest Diseases and Surgery Training and Research Hospital between 2015 and 2018 were screened retrospectively and included in the …
Resting-State Static And Dynamic Functional Abnormalities In Active Professional Fighters With Repetitive Head Trauma And With Neuropsychological Impairments.,
2020
Pickup Family Neuroscience Institute, Hoag Memorial Hospital Presbyterian, Newport Beach, CA, United States.
Resting-State Static And Dynamic Functional Abnormalities In Active Professional Fighters With Repetitive Head Trauma And With Neuropsychological Impairments., Xiaowei Zhuang, Virendra Mishra, Rajesh Nandy, Zhengshi Yang, Karthik Sreenivasan, Lauren Bennett, Charles Bernick, Dietmar Cordes
Articles, Abstracts, and Reports
Previous neuroimaging studies have identified structural brain abnormalities in active professional fighters with repetitive head trauma and correlated these changes with fighters' neuropsychological impairments. However, functional brain changes in these fighters derived using neuroimaging techniques remain unclear. In this study, both static and dynamic functional connectivity alterations were investigated (1) between healthy normal control subjects (NC) and fighters and (2) between non-impaired and impaired fighters. Resting-state fMRI data were collected on 35 NC and 133 active professional fighters, including 68 impaired fighters and 65 non-impaired fighters, from the Professional Fighters Brain Health Study at our center. Impaired fighters performed worse …
Spatial Memory And Executive Functioning In The Goto-Kakizaki Rat Model Of Diabetes,
2020
Wilfrid Laurier University
Spatial Memory And Executive Functioning In The Goto-Kakizaki Rat Model Of Diabetes, Lorielle Dietze
Theses and Dissertations (Comprehensive)
Type 2 diabetes mellitus is a disease that adversely affects cognitive function in areas extending to memory and executive functioning. The Goto-Kakizaki (GK) rat provides a model of type 2 diabetes that can illustrate the mechanisms by which this disease works. The present study compared hyperglycaemic GK rats and age-matched Wistar rats in the Morris water maze to assess spatial memory, and in a perceptual attentional set-shifting task to assess putative prefrontal-dependent executive functioning. Results showed there was no difference in path length during training trials, however, GK and Wistar rats differed in the path length travelled in the target …
The Role Of Neutrophils In Chronic Heart Failure,
2020
University of Alabama at Birmingham
The Role Of Neutrophils In Chronic Heart Failure, Sergey Antipenko
All ETDs from UAB
Acute myocardial infarction (MI) produces massive, sudden cardiomyocyte death, triggering an inflammatory and healing response that initially leads to scar formation and ultimately may induce progressive ischemic cardiomyopathy and heart failure (HF). Scar formation and left ventricular (LV) hypertrophy occur in response to MI to stabilize injury compensating for lost myocardial function. Over time, heart function can become decompensated due to neuroendocrine dysfunction and adverse LV remodeling, ultimately leading to HF. Adverse remodeling is characterized by continued dysregulated collagen deposition, cardiomyocyte hypertrophy, and increased inflammation. Studies have documented a resurgence in inflammatory cytokines and infiltrating leukocytes after resolution of the …
Impact Of Diet And Meal Timing On Time-Of-Day Dependent Hippocampal Function,
2020
University of Alabama at Birmingham
Impact Of Diet And Meal Timing On Time-Of-Day Dependent Hippocampal Function, Jennifer Davis
All ETDs from UAB
Circadian rhythms are biological processes that cycle every ~24 hours and have allowed life to adapt for optimal function across the day. These rhythms are present in all tissues in the body and are coordinated to the light/dark cycle by the suprachiasmatic nucleus (SCN) in the hypothalamus. Along with active-rest cycles, cognitive performance fluctuates across the course of the day, peaking during the active phase. In addition to the light cycle, food and meal timing can provide signaling cues to extra-SCN tissues. Food access only during the inactive phase results in weight gain and memory impairment. High fat diet protocols …
Rna Polymerase I Elongation Kinetics: A Biochemical And Global Study Of A Cancer Therapeutic Target,
2020
University of Alabama at Birmingham
Rna Polymerase I Elongation Kinetics: A Biochemical And Global Study Of A Cancer Therapeutic Target, Catherine Elizabeth Scull
All ETDs from UAB
My graduate research has focused on understanding the elongation kinetics of RNA polymerase I (Pol I), the enzyme responsible for synthesizing ribosomal RNA (rRNA), and defining how inhibition of ribosome biogenesis may be used as a cancer therapeutic strategy. Here, I have defined key biophysical features of Pol I and I have expanded the field’s understanding of Pol I elongation by: 1) characterizing the enzymatic properties of Pol I by mutational analysis of the polymerase itself, and by 2) elucidating the role of DNA sequence on Pol I arrest and nucleolytic cleavage activity. In recent years, Pol I has become …
Distinct Tissue Specific Functions Of Bone Marrow Regulatory T Cells, And Their Therapeudic Applications In Myeloid Neoplasms,
2020
University of Alabama at Birmingham
Distinct Tissue Specific Functions Of Bone Marrow Regulatory T Cells, And Their Therapeudic Applications In Myeloid Neoplasms, Virginia Camacho
All ETDs from UAB
In the bone marrow, Regulatory T cells (Tregs) constitute nearly 30% of CD4+ T cells, a significantly higher ratio than other tissues. Although a few of the mechanisms by which Tregs regulate normal hematopoiesis have been elucidated, our understanding of this process during leukemogenesis is ex-tremely limited. In this work, we define how Tregs maintain and support the bone marrow microenvironment. We propose that the role of Tregs extends be-yond their canonical immuno-suppressive function and that these cells are re-quired to maintain healthy hematopoiesis. We have defined tissue-specific roles for Tregs in the bone marrow including the maintenance of hematopoietic …
Noninvasive Neuromodulation Using A Benchtop Approach To Mri-Guided Focused Ultrasound Blood Brain Barrier Opening,
2020
University of Alabama at Birmingham
Noninvasive Neuromodulation Using A Benchtop Approach To Mri-Guided Focused Ultrasound Blood Brain Barrier Opening, Megan Rich
All ETDs from UAB
Fundamental neuroscience research has provided a deeper understanding of the genes, molecules and cellular circuitry involved in neurological disorders, however translating discovery into clinical application remains a major challenge. This bench to bedside gap is in part due to the discrepancy in techniques used in the laboratory vs. the clinic for targeting the mechanisms that underlie disease. Ideally this discrepancy would be resolved not only by implementing novel clinical techniques to provide more precise targeting of disease foci, but also by using the same techniques in the clinic that are used at the lab bench to provide a direct bench …
Novel Mechanisms Of Nitric Oxide Activation In The Kidney,
2020
University of Alabama at Birmingham
Novel Mechanisms Of Nitric Oxide Activation In The Kidney, Randee Sedaka
All ETDs from UAB
Globally, adult sodium consumption has far exceeded daily intake recommendations, leading to one in ten cardiovascular deaths. Given the rise in hypertension prevalence, uncontrolled hypertension with antihypertensive medication use, and significant associations between high salt intake and high blood pressure, there is a need to better understand the mechanisms involved in hypertension. Nitric oxide synthase 1 (NOS1) is a well-established regulator of fluid and electrolyte balance in the renal collecting duct (CD) with highest activity in the inner medulla (IM). We previously reported that high salt (HS) intake stimulates CD endothelin B receptor (ETBR)/NOS1-dependent generation of NO, thereby inhibiting the …
