Medical Sciences Commons^™

Metabolic Pathways Enriched According To Erg Status Are Associated With Biochemical Recurrence In Hispanic/Latino Patients With Prostate Cancer, Natalia L. Acosta-Vega, Rodolfo Varela, Jorge Andrés Mesa, Jone Garai, Melody C. Baddoo, Alberto Gómez-Gutiérrez, Silvia J. Serrano-Gómez, Marcela Nuñez Lemus, Martha Lucía Serrano, Jovanny Zabaleta, Alba L. Combita, María Carolina Sanabria-Salas

School of Medicine Faculty Publications

Background: The role of ERG-status molecular subtyping in prognosis of prostate cancer (PCa) is still under debate. In this study, we identified differentially expressed genes (DEGs) according to ERG-status to explore their enriched pathways and implications in prognosis in Hispanic/Latino PCa patients. Methods: RNA from 78 Hispanic PCa tissues from radical prostatectomies (RP) were used for RNA-sequencing. ERGhigh/ERGlow tumor groups were determined based on the 1.5-fold change median expression in non-tumor samples. DEGs with a False Discovery Rate (FDR) < 0.01 and a fold change >2 were identified between ERGhigh and ERGlow tumors and submitted to enrichment analysis in MetaCore. Survival and association analyses were performed …

Creatively Capturing Structure And Energy: Zero Balancing's Essential Elements (Article & Video), Lisa Bardarson

Journal of Transformative Touch

Through the creative use of coloring, I am devising a way to document Zero Balancing’s two foundational elements, structure and energy and the changes that occur following a ZB session. I believe this experiential activity will be a creative fulcrum, helping the client connect more effectively with the deepest part of themselves thereby experiencing greater ease and freedom from their issues. As the activity of coloring is a “right brain”/ creative endeavor, I believe it can serve to enhance a client’s expanded state of consciousness, one of the hallmarks of a Zero Balancing session, as well as improve their overall …

Editorial: Epigenetics And Molecular Genetics Of Rare Tumors, Mauro Tognon, George A. Calin, Luis Del Valle

School of Medicine Faculty Publications

No abstract provided.

Children’S Experiences Of Hospitalization Over Time: An Evaluation Of Using Poetry And Creative Writing By Children To Assess Their Experiences Of Hospitalization, David Wood

Patient Experience Journal

This article explores children’s experiences of hospital admissions through their poetry and creative writing and assesses the validity of this medium compared to other methods of evaluation. Pediatric patient experiences of hospital and their effects on children have been studied in various ways and there have been stepwise changes throughout the past century, matching the overall changes of medical care from paternalistic to patient centered. 17 poems were analyzed from children aged 6-13 years old (median 10) for recurrent themes whilst admitted to a large tertiary hospital in the north of England. Children frequently wrote about attacks on their senses, …

The Importance Of Patient Engagement In The Management Of Giant Cell Arteritis, Nikhil S. Patil, Maxwell J. Gelkopf, Santano L. Rodrigues, Arun Ne. Sundaram

Patient Experience Journal

Giant cell arteritis (GCA) is a vascular condition characterized by ocular, systemic and neurological symptoms. Visual loss is the dreaded complication of this condition, prompting expedient diagnosis and treatment. Treatment typically involves prolonged glucocorticoid therapy which is often accompanied by several undesired side effects. In this report, we document one patient’s experience with GCA, its treatment, and relapse. Particularly, the patient highlights the difficulties and successes he had with the disease and its treatment. We also document the physician perspective on this disease and its treatment, specifically discussing the significance of prolonged treatment with glucocorticoids. We comment on the importance …

Living With Brain Cancer: From Researcher To Patient, Stephen P. Chelko, Daniel L. Fay Ph.D.

Patient Experience Journal

As an academic researcher, my work-life revolves around testing the efficaciousness of pharmaceutical drugs on the prevention of cardiac dysfunction, arrhythmias, and sudden cardiac death in animal models of heart disease. I never thought I would go from someone studying a life-threatening disease to a patient living with one in twenty-four hours. Yet, that transformation occurred October 8, 2019. I was just appointed to Assistant Professor at Johns Hopkins University School of Medicine (JHUSOM), yet after sitting for my professional headshot I had a grand mal seizure. I cannot recall this event, but I bit the tip of my tongue …

Investigating The Role Of The Hedgehog Pathway In Connection To Atrazine Endocrine Disruption, Anusha Kv Lakshmi Dharmavathi

The Journal of Purdue Undergraduate Research

No abstract provided.

Developmental Behavioral Alterations Following Lead (Pb) Exposure In The Zebrafish Model System, Jenny Chen

The Journal of Purdue Undergraduate Research

No abstract provided.

Working Out The Kinks: Creating Solutions To Assist Health Care Workers To Take Vital Signs Through Effective Cable Management, Carl R. Russell Iii, Emily J. Linder, Maya A. Godbole

Purdue Journal of Service-Learning and International Engagement

EPICS (Engineering Projects in Community Service) is a service-learning design program run through Purdue University. It strives to teach students design skills through providing solutions for individuals, communities, and organizations in the surrounding area while mirroring engineering industry standards. BME (Bio-medical Engineering) is a team within EPICS that strives to serve community partners through biomedical applications. Members of a health care team often spend valuable time organizing cables associated with machines used to take patients’ vital signs. Due to time constraints and the fast-paced work environment, these cables may be mismanaged and damaged. The BME team is working on a …

Examining The Effects Of Formal Education Level On The Montreal Cognitive Assessment, Renee S. White, Justin M. Barber, Jordan P. Harp, Gregory A. Jicha

Sanders-Brown Center on Aging Faculty Publications

Background: Brief, global assessments such as the Montreal Cognitive Assessment (MoCA) are widely used in primary care for assessing cognition in older adults. Like other neuropsychological instruments, lower formal education can influence MoCA interpretation.

Methods: Data from 2 large studies of cognitive aging were used—Alzheimer’s Disease Neuroimaging Initiative (ADNI) and National Alzheimer’s Coordinating Center (NACC). Both use comprehensive examinations to determine cognitive status and have brain amyloid status for many participants. Mixed models were used to account for random variation due to data source.

Results: Cognitively intact participants with lower education (≤12 years) were more likely than …

Multiple Gene Variants Linked To Alzheimer's-Type Clinical Dementia Via Gwas Are Also Associated With Non-Alzheimer's Neuropathologic Entities, Yuriko Katsumata, Lincoln M. P. Shade, Timothy J. Hohman, Julie A. Schneider, David A. Bennett, Jose M. Farfel, Walter A. Kukull, David W. Fardo, Peter T. Nelson

Sanders-Brown Center on Aging Faculty Publications

The classic pathologic hallmarks of Alzheimer’s disease (AD) are amyloid plaques and neurofibrillary tangles (AD neuropathologic changes, or ADNC). However, brains from individuals clinically diagnosed with “AD-type” (amnestic) dementia usually harbor heterogeneous neuropathologies in addition to, or other than, ADNC. We hypothesized that some AD-type dementia associated genetic single nucleotide variants (SNVs) identified from large genomewide association studies (GWAS) were associated with non-ADNC neuropathologies. To test this hypothesis, we analyzed data from multiple studies with available genotype and neuropathologic phenotype information. Clinical AD/dementia risk alleles of interest were derived from the very large GWAS by Bellenguez et al. (2022) who …

Possibilities Of Using Neuromarketing Tools In The Hospitality Industry, Serdar Bulbul

University of South Florida (USF) M3 Publishing

Usage of neurosciences in social sciences has emerged new perspectives and methods for marketing and tourism marketing. Neuro-marketing and Neuro-tourism are some of those concepts. In the hospitality industry, marketing is in a complex state because the decision-making processes of the guests are unpredictable. For this reason, hotel managements are unable to satisfy guest’s requests and demands with traditional methods. Therefore, Neuro-marketing has importance because this new way of marketing has a high chance to replace currently used methods. Usage of Neuro-marketing in the hospitality industry could satisfy the guest requests while generating new marketing perspectives on hotel management. This …

Utility Of Magnetic Activated Cell Sorting (Macs) In Assisted Reproduction, Adel Abou El-Ela, Ahmed Kandeel, Eman Hassan, Mohamed Nasr, Yomna Esam

Al-Azhar International Medical Journal

Magnetic activated cell sorting (MACS) has mechanisms to reduce the degrees of Deoxyribonucleic acid (DNA) fragmentation done to the sperm sample in sperm processing pre-injection since no density gradient is involved or heavy centrifugation steps involved. If DNA fragmentation is not eliminated from sperms, poor cleavage rate, bad embryo quality, poor implantation and low pregnancy rates may occur. A MACS is Nano-sized mixture of particles with high magnetic properties coated with glycoproteins for morbid/DNA fragmented Spermatozoa depletion prior to Intra Cytoplasmic Sperm Injection (ICSI). Several studies have shown that the using of MACS technique improve the outcomes of ICSI in …

Comparative Study Between Transversus Abdominus Plain Block, Local Subcutaneous Injection In Wound And Intravenous Nalbuphine In Decreasing Post-Operative Pain In Cesarean Section, Mahmoud Mohammed, Mohammed Mohammed, Elsayed Eldesouky, Amr Hamroush

Al-Azhar International Medical Journal

Background; Cesarean delivery is the birth of a baby via surgical incisions in the abdominal wall (laparotomy) and the uterine wall (hysterotomy), Aim of the study: The goal of this research is to compare between the analgesic effects of different ways to relieve post cesarean section pain in terms of pain relief, duration of pain relief and need of adding other analgesics and number of these analgesics. Patients and methods: Patients who were scheduled for elective CS were informed about the experiment at their preoperative anesthesia assessment. Patients having a history of drug addiction or a significant drug allergy were …

Prevalence And Types Of Abnormally Adherent Placenta In Women With Cs, Mohamed Mohamed, Ibrahim Abousekein, Attia Attia

Al-Azhar International Medical Journal

Background: A variety of complications has become a direct result of increasing the rate of cesarean section which includes postpartum haemorrhage, sepsis, visceral injury, postoperative ileus, placenta previa and morbidly adherent placenta; Aim and objectives: The aim of the research was to detect the prevalence of morbidly adherent placenta among women with variety of numbers of previous cesarean sections. Subjects and methods: This was a prospective cross-sectional research that took place in an inpatient, outpatient and emergency of Sayed Galal maternity hospital Fuculty of Medicine Al-Azher University. Result: there is high significant relation between number of previous cesarean section (P.C.S) …

Diagnostic Value Of Neutrophil-Lymphocyte Ratio In Exudative Pleural Effusion, Ebrahim Ewida, Houssam Eldin Abd Elnaby, Ebrahim Deraz, Yousry Alzohairy

Al-Azhar International Medical Journal

Background: As many patients may be unfit to undergo medical thoracoscopy, in addition to the low yield of closed pleural biopsy in malignant conditions, finding novel hematological or pleural fluid biomarkers to unmask the diagnosis of exudative pleural effusion and guide management plan becomes of increasing importance. Aim of the study: This work aimed at assessing the role of neutrophil to lymphocyte ratio in either blood or pleural fluid as a simple biomarker in detecting the underlying etiology of exudative pleural effusion. Patients and Methods: This cross sectional study took place at Bab Al-Sha’reia University Hospital in the period between …

Diagnostic Aspects Of Multi-Detector Ct In Detection Of Coronary Arteries Stenotic Lesions Diseases Versus Interventional Diagnostic Angiography, Mohammed Abd El Gowad, Mohamed Abd El Moaty, Mohamed Ibraheem

Al-Azhar International Medical Journal

Background: Invasive coronary angiography (ICA) is anatomical evaluation of coronary artery disease is considered gold standard. Aim of the study: to compare the diagnostic characteristics of non-invasive computed Tomography (CT) coronary angiography to invasive coronary angiography in diagnosis of coronary artery stenosis and their economic benefits. Patients and methods: This study was descriptive Observational study, thirty studied cases included in research. Patients are undergone ECG gated MDCT coronary angiography in CT unit in Radiology Department of National Heart Institute NHI was analyzed from PACS (Syngovia acquisition system) and we was included patients for detection of coronary stenotic lesions compared to …

Role Of Ct-Virtual Bronchoscopy In Haemoptysis, Emaduddien Saaduddien, Ahmad Aborashed, Mohamed Elfeshawy, Fareed Basiony

Al-Azhar International Medical Journal

Background: For tracheobronchial diseases, fiberoptic bronchoscopy (FOB) continues to be the gold standard diagnosing technique. It is a rather secure diagnostic and treatment method. Because of its excellent sensitivity, fiberoptic endoscopy is now the primary diagnostic method for assessing tracheobronchial endoluminal and mucosal diseases. Objective: to compare traditional fiberoptic bronchoscopy, which is thought to be the gold standard screening tool for tracheobronchial pathologies, with virtual bronchoscopy as a screening tool in identifying tracheobronchial disorders in patients having clinical and/or radiological reason for bronchoscopy. Patients and Methods: Patients who required tracheobronchial examination using bronchoscopy due to a clinical, radiological, or other …

The Additive Effect Of Topical Dorzolamide-Timolol With Intravitreal Ranibizumab Injection In Diabetic Macular Edema, Sara Gadwal, Wafaa Madbouly, Mona Mansour

Al-Azhar International Medical Journal

Background: Diabetic macular edema (DME) is a main reason for vision affection when occurred at any stage of diabetic retinopathy. Anti-vascular endothelial growth factor agents is the gold standard treatment for DME. Adjuvant agents may decrease edema and improve vision. Aim of the work: To assess influence of topical dorzolamide–timolol with intravitreal ranibizumab injection (IVR) on anatomical and functional outcomes in DME. Patients & Methods: This prospective cohort study included thirty patients (30 eyes) having type 2 DM, aged 45-60 years, all eyes have DME. They were divided into 2 groups according to treatment protocol: Group 1: 15 patients (15 …

Endoscopic Approach For Management Of Colloid Cyst, Mahmoud Abdelaal, Adel Almelesy, Alazzazi Alazzazi

Al-Azhar International Medical Journal

Background: Third ventricular colloid cysts are uncommon tumors that make up 15 to 20% of intraventricular tumors and 0.2 to 2% of intracranial tumors. Colloid cysts are benign tumors, but they may grow until they block the foramen of Monro, which might result in a fatal accident. Aim of the Work: Assessment of the efficacy of endoscopic excision(total or subtotal) of the colloid cyst in relation to the size of cyst Patients and Methods: The research was prospectively carried out at the neurosurgery department of Al-Azhar university hospitals, from January 2019 to December 2021. Included fifteen patients with colloid cyst …