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Articles 541 - 570 of 4871
Full-Text Articles in Medicine and Health Sciences
Early Assessment Of Extremity Compartment Syndrome By Biochemical Markers In A Rat Model, Ahmet Yildirim, İbrahi̇m Özkan Önal, Zeli̇ha Esi̇n Çeli̇k, Hüsametti̇n Vatansev, Esra Paydaş Hataysal
Early Assessment Of Extremity Compartment Syndrome By Biochemical Markers In A Rat Model, Ahmet Yildirim, İbrahi̇m Özkan Önal, Zeli̇ha Esi̇n Çeli̇k, Hüsametti̇n Vatansev, Esra Paydaş Hataysal
Turkish Journal of Medical Sciences
Background/aim: This experimental study aimed to define a biochemical marker that will enable early diagnosis of acute compartment syndrome (ACS) of extremities, a mortal condition that occurs due to trauma. Materials and methods: A total of 15 Wistar rats were included in the study in which saline infusion technique, a clinically compatible ACS model, was applied. After the rats were anesthetized with ketamine-xylazine, the in-compartment pressure of the hind limb was slowly increased with saline delivered through the angiocatheter, and after reaching the target compartment pressure, the pressure level was kept with a rubber tourniquet. The in-compartment pressure level was …
Effect Of Crocin And Losartan On Biochemical Parameters And Genes Expression Of Frmd3 And Bmp7 In Diabetic Rats, Yaser Mohammadi, Mohammad Zangooei, Fatemeh Salmani, Azam Rezaei Farimani
Effect Of Crocin And Losartan On Biochemical Parameters And Genes Expression Of Frmd3 And Bmp7 In Diabetic Rats, Yaser Mohammadi, Mohammad Zangooei, Fatemeh Salmani, Azam Rezaei Farimani
Turkish Journal of Medical Sciences
Background/aim: Diabetes is a multifactorial and growing disease, one of the severe complications of which is diabetic nephropathy (DN), which is the most common cause of chronic renal failure. FERM domain containing 3 (FRMD3) is responsible for maintaining the shape and integrity of nephron cells, and bone morphogenetic protein 7 (BMP7) helps maintain function and reduce kidney damage. This study aimed to evaluate the effect of crocin and losartan on biochemical parameters and the expression of FRMD3 and BMP7 genes in streptozotocin (STZ)-induced diabetic rats. Materials and methods: Forty male Wistar rats were randomly divided into five experimental groups as …
Effects Of Recurrent Ketamine Exposure On Brain Histopathology In Juvenile Rats, Ayşe Hande Arpaci, Süheyla Esra Özkoçer, Emel Güneş, Çi̇ğdem Elmas, Berri̇n Işik
Effects Of Recurrent Ketamine Exposure On Brain Histopathology In Juvenile Rats, Ayşe Hande Arpaci, Süheyla Esra Özkoçer, Emel Güneş, Çi̇ğdem Elmas, Berri̇n Işik
Turkish Journal of Medical Sciences
Background/aim: Ketamine (KET) is a commonly used anesthetic agent. However, several previous studies reported that KET leads to neuronal damage in neurodevelopmental stages and has neuroprotective effects. The present experimental study aimed to determine the undesirable histopathological effects of KET in the cerebral cortex, striatum, and hippocampus after recurrent KET administration in juvenile rats. Materials and methods: After ethical approval was obtained, 32 juvenile male Wistar Albino rats were randomized into four groups: 1 mg/kg serum saline intraperitoneally (i.p.), 5 mg/kg KET i.p., 20 mg/kg KET i.p., and 50 mg/kg KET i.p. KET was administered for three consecutive days at …
Investigation Of Taurine And Aqueous Garlic Extract Diet Supplementation Effect On The Healing Of Rat Osteoporotic Fractures, Mesut Misirlioğlu, İzzet Bi̇ngöl, Coşkun Genç, Ayli̇n Akbulut, Mert Ocak, Nezi̇ha Yağmur Di̇ker, Ahmet Özmeri̇ç, Gökhan Koca, Meli̇ke Bahçeci̇tapar, Mehmet Şeneş, Ayşegül Firat, Fevzi̇ye Fi̇gen Kaymaz, Hakan Hamdi̇ Çeli̇k, İffet İrem Çankaya, Meli̇ha Korkmaz
Investigation Of Taurine And Aqueous Garlic Extract Diet Supplementation Effect On The Healing Of Rat Osteoporotic Fractures, Mesut Misirlioğlu, İzzet Bi̇ngöl, Coşkun Genç, Ayli̇n Akbulut, Mert Ocak, Nezi̇ha Yağmur Di̇ker, Ahmet Özmeri̇ç, Gökhan Koca, Meli̇ke Bahçeci̇tapar, Mehmet Şeneş, Ayşegül Firat, Fevzi̇ye Fi̇gen Kaymaz, Hakan Hamdi̇ Çeli̇k, İffet İrem Çankaya, Meli̇ha Korkmaz
Turkish Journal of Medical Sciences
Background/aim: We have evaluated the effects of taurine and aqueous garlic extract (AGE) as a dietary supplement on osteoporotic fracture (OPF) healing in the ovariectomized rat femur fracture model. Materials and methods: In this experimental animal study,twenty-four osteoporosis-remodeled female Wistar albino rats were randomly divided into 3 groups (n: 8) according to their supplemented diet; control, taurine, and AGE groups. Unilateral femur middiaphysis mini-open osteotomy was stabilized with Kirschner wires. Six weeks after osteotomy, the rats were sacrificed before the femurs were harvested and OPF healing was evaluated with biochemical, histologic, microcomputed-tomography, and scintigraphic methods. Results: As an indicator of …
The Role Of Curcumin Against Paclitaxel-Induced Oxidative Stress And Dna Damage In Testes Of Adult Male Rats, Esra Balcioğlu, Özge Göktepe, Fazi̇le Cantürk Tan, Pinar Bi̇lgi̇ci̇, Bi̇rkan Yakan, Sai̇m Özdamar
The Role Of Curcumin Against Paclitaxel-Induced Oxidative Stress And Dna Damage In Testes Of Adult Male Rats, Esra Balcioğlu, Özge Göktepe, Fazi̇le Cantürk Tan, Pinar Bi̇lgi̇ci̇, Bi̇rkan Yakan, Sai̇m Özdamar
Turkish Journal of Medical Sciences
Background/aim: Paclitaxel is a widely used drug for the treatment of cancer, but it possesses toxic effects on male reproductive system. Administering paclitaxel with an antioxidant has become a strategy for preventing the side effects of paclitaxel. Although curcumin is an antioxidant, data concerning the effect of curcumin on paclitaxel-induced testis tissue are lacking. The present study was established to examine the protective impact of curcumin against testicular damage induced by paclitaxel. Materials and methods: In the study, 40 Wistar albino male rats were used and randomly divided into 4 groups (n:10). The control group received only saline solution; the …
An Experimental Study: The Effect Of S. Boulardii On Abemaciclib-Induced Diarrhea, İbrahi̇m Ethem Cakcak, Yusuf Emre Ayti̇n, Sezi̇n Sayin, Ahmet Küçükarda, Ali̇ Gökyer, İvo Gökmen, Erkan Özcan, Selçuk Korkmaz, Ebru Taşteki̇n, İrfan Çi̇çi̇n
An Experimental Study: The Effect Of S. Boulardii On Abemaciclib-Induced Diarrhea, İbrahi̇m Ethem Cakcak, Yusuf Emre Ayti̇n, Sezi̇n Sayin, Ahmet Küçükarda, Ali̇ Gökyer, İvo Gökmen, Erkan Özcan, Selçuk Korkmaz, Ebru Taşteki̇n, İrfan Çi̇çi̇n
Turkish Journal of Medical Sciences
Background/aim: In our study, we aimed to investigate the protective effects of Saccharomyces boulardii on abemaciclib-induced diarrhea model, which is a commonly used drug in breast cancer. Materials and methods: Thirty rats were divided into 3 groups as control (Group 1), abemaciclib (Group 2), and abemaciclib + Saccharomyces boulardii (Group 3) groups. The clinical status, body weight, and defecation status were monitored daily. At the end of the 15-day experiment period, the rats were killed with high-dose anesthesia and the resected small intestine segments were evaluated histopathologically. Lesions were classified according to thickening of the villus, inflammation and edema of …
Evaluation Of The Effects Of Three Natural Products And A Hemostatic Agent On Wound Healing: An Experimental Study, Ayşe Çeli̇k Yilmaz, Di̇lek Aygi̇n
Evaluation Of The Effects Of Three Natural Products And A Hemostatic Agent On Wound Healing: An Experimental Study, Ayşe Çeli̇k Yilmaz, Di̇lek Aygi̇n
Turkish Journal of Medical Sciences
Background/aim: People have used many natural materials such as plant leaves, roots, liquids derived from plants, and animal products to treat wounds throughout history. It can be said that the research on wound care in recent years have focused on traditional and natural products again. This study aimed to investigate the effects of sweetgum oil, propolis, silk protein, and Ankaferd Blood Stopper (ABS) on wound healing in an experimental excisional wound model. Materials and methods: Including 36 Balb/c inbreed mice in the study were divided equally into four groups. Two circular excisional wounds were created on the dorsal skin of …
Is Advanced Bipolar Vessel Sealing Device Really Effective In Decreasing The Pelvic Lymphocele Ratio In Open Surgery For Endometrial Cancer?, Mehmet Ali̇ Nari̇n, Sevda Baş, Sevtap Seyfetti̇noğlu, Tuba Yar, Razi̇ye Nari̇n
Is Advanced Bipolar Vessel Sealing Device Really Effective In Decreasing The Pelvic Lymphocele Ratio In Open Surgery For Endometrial Cancer?, Mehmet Ali̇ Nari̇n, Sevda Baş, Sevtap Seyfetti̇noğlu, Tuba Yar, Razi̇ye Nari̇n
Turkish Journal of Medical Sciences
Background/aim: We aim to show pelvic lymphocele (PL) rates in patients who were operated for endometrial cancer (EC) and underwent systematic paraaortic bilateral pelvic lymph node dissection (PABPLND) with advanced bipolar vessel sealing device (ABVSD) Materials and methods: The medical files of all patients who underwent open surgery for EC between January 2017 and December 2021 were retrospectively analyzed. One hundred three patients who operated with the diagnosis of high-intermediate and high-risk endometrial cancer were included. Systematic PABPLND was performed with total abdominal hysterectomy with or without bilateral salpingo-oophorectomy during surgery to all patients. All operations were performed by same …
Primary Versus Secondary Intraocular Lens Implantation Following Removal Of Congenital/Developmental Cataracts: Outcomes After At Least 4 Years, Ayşi̇n Tuba Kaplan, Si̇bel Öskan Yalçin, Ayşe Yeşi̇m Oral
Primary Versus Secondary Intraocular Lens Implantation Following Removal Of Congenital/Developmental Cataracts: Outcomes After At Least 4 Years, Ayşi̇n Tuba Kaplan, Si̇bel Öskan Yalçin, Ayşe Yeşi̇m Oral
Turkish Journal of Medical Sciences
Background/aim: The aim of this study is to evaluate the long-term outcomes of primary and secondary intraocular lens (IOL) implantation following removal of congenital/developmental cataracts. Materials and methods: One hundred and forty-four patients aged under 16 years who were followed up between 2003 and 2021 were analyzed retrospectively. The long-term results of children who underwent surgery before 2 years of age for congenital or developmental cataracts and underwent secondary IOL implantation after 2 years of age and those who underwent cataract surgery with primary IOL implantation after 2 years of age were compared. Patients with traumatic, secondary cataracts and cataracts …
Postnatal Surgery For Myelomeningocele In Neonates: Neurodevelopmental Outcomes, Melek Akar, Gülşah Çeti̇n, Mi̇ne İnal, Mehmet Helvaci, Ni̇hal Olgaç Dündar, Firat Ergi̇n, Özgün Uygur, Si̇nem Akbay, Nai̇l Özdemi̇r, Meltem Koyuncu Arslan, Mehmet Yekta Öncel
Postnatal Surgery For Myelomeningocele In Neonates: Neurodevelopmental Outcomes, Melek Akar, Gülşah Çeti̇n, Mi̇ne İnal, Mehmet Helvaci, Ni̇hal Olgaç Dündar, Firat Ergi̇n, Özgün Uygur, Si̇nem Akbay, Nai̇l Özdemi̇r, Meltem Koyuncu Arslan, Mehmet Yekta Öncel
Turkish Journal of Medical Sciences
Background/aim: The study aims to evaluate the neurodevelopmental outcomes of neonates with myelomeningocele (MMC) operated in the postnatal period. Materials and methods: This is a prospective follow-up study in a tertiary neonatal intensive care unit. Neurodevelopmental outcomes of term neonates operated for MMC and healthy term newborns were compared with the Bayley Scales of Infant and Toddler Development -Third Edition (BSID III) at 12-18 months. Results: A total of 57 cases were included in the study (patient group = 27; control group = 30). Demographic data between the groups were similar. Cognitive, linguistic, and motor composite scores of the patient …
Transbronchial Lung Cryobiopsy For The Diagnosis Of Diffuse Parenchymal Lung Disease: Pitfalls And Challenges, A Single Center Experience, Kemal Can Tertemi̇z, Ayli̇n Özgen Alpaydin, Nurcan Güler, Volkan Karaçam, Duygu Gürel, Naci̇ye Si̇nem Gezer
Transbronchial Lung Cryobiopsy For The Diagnosis Of Diffuse Parenchymal Lung Disease: Pitfalls And Challenges, A Single Center Experience, Kemal Can Tertemi̇z, Ayli̇n Özgen Alpaydin, Nurcan Güler, Volkan Karaçam, Duygu Gürel, Naci̇ye Si̇nem Gezer
Turkish Journal of Medical Sciences
Background/aim: Transbronchial lung cryobiopsy (TBLC) is a minimally invasive technique of the diagnosis of diffuse parenchymal lung diseases (DPLD). The aim of this study is to determine the clinical-radiological and histopathological characteristics of patients in whom cryobiopsy contributes to the diagnosis. Materials and methods: In this retrospective study, we searched for the medical records of patients who underwent TBLC from July 2015 to March 2020 at the pulmonology department of our university hospital clinic. Radiological images were evaluated by a chest radiologist experienced in DPLD. Prediagnosis was indicated by clinical-radiological findings. The final diagnosis was determined by the contribution of …
Can Amniotic Fluid Protect Developing Fetal Lungs Against The Harmful Effects Of Oxidative Stress?, Levent Korkmaz, Cumali̇ Alan, İsmai̇l Topal, Mahi̇r Tayfur, Ali̇seydi̇ Bozkurt, Cebrai̇l Gürsul, Osman Baştuğ
Can Amniotic Fluid Protect Developing Fetal Lungs Against The Harmful Effects Of Oxidative Stress?, Levent Korkmaz, Cumali̇ Alan, İsmai̇l Topal, Mahi̇r Tayfur, Ali̇seydi̇ Bozkurt, Cebrai̇l Gürsul, Osman Baştuğ
Turkish Journal of Medical Sciences
Background/aim: Preterm births cause fetuses to be born without completing the development of their organs. Due to this undesirable situation, it is the pulmonary tissue which has to be most exposed to harmful effects of extrauterine environment. Early disappearance of the prophylactic and constructive effects of amniotic fluid (AF) on developing tissues, such as pulmonary tissue, facilitates the formation of pulmonary morbidities resulting from oxygen. Setting out from this knowledge, we wanted, in addition to assessing the beneficent effects of AF on pulmonary tissue, to study the importance of AF in morbidities of this tissue thought to originate from oxygen. …
A New Method For Second Toe Flap Revascularization In Plantar Dominant Artery Pattern - Dorsal Metatarsal Artery Interpositional Graf, Erhan Sönmez, Ersi̇n Akşam, İlker Uyar
A New Method For Second Toe Flap Revascularization In Plantar Dominant Artery Pattern - Dorsal Metatarsal Artery Interpositional Graf, Erhan Sönmez, Ersi̇n Akşam, İlker Uyar
Turkish Journal of Medical Sciences
Background/aim: Toe transfer to hand is a viable option for patients, which can provide functionally useful digits. Harvesting of the second toe is still accepted as a demanding surgical procedure. The major questions before this transfer are the location and the dominance of the arterial anatomy of the second toe. The authors present the incidence of patients with a dominant plantar artery system and a description of a versatile technique that can be used for toe transfers in these patients. Materials and methods: The study was designed retrospectively. Toe to hand transfers performed between 2010 and 2018 were reviewed. The …
Effects Of Breast Milk On Behçet's Disease Clinical Features, Hati̇ce Ecem Konak, Abdulsamet Erden, Berkan Armağan, Serdar Can Güven, Hakan Apaydin, Pinar Akyüz Dağli, Yağnur Uzun, Merve Kaygisiz, Orhan Küçükşahi̇n, Ahmet Omma
Effects Of Breast Milk On Behçet's Disease Clinical Features, Hati̇ce Ecem Konak, Abdulsamet Erden, Berkan Armağan, Serdar Can Güven, Hakan Apaydin, Pinar Akyüz Dağli, Yağnur Uzun, Merve Kaygisiz, Orhan Küçükşahi̇n, Ahmet Omma
Turkish Journal of Medical Sciences
Background/aim: The etiology of Behçet's disease (BD) is not clearly known, however, abnormal activity in T helper (Th) 1, Th 17, and regulatory T cells (Treg) has critical importance in pathogenesis. It has been shown that the intestinal microbiome can be effective in the modulation of these immune abnormalities in BD patients. Breastfeeding increases the maturation of the infant's intestinal permeability by affecting the newborn's immature intestinal microbiome and metagenome. We aimed to examine the effects of breastfeeding on disease related symptoms, organ involvements and course of the disease in BD patients. Materials and methods: This study was designed as …
Decreased Circulating Microrna-21 And Microrna-143 Are Associated To Pulmonary Hypertension, Zekeri̇ya Düzgün, Lati̇fe Meral Kayikçioğlu, Çağdaş Aktan, Buşra Bara, Fatma Zuhal Eroğlu, Burcu Yağmur, Vi̇ldan Bozok Çeti̇ntaş, Meli̇ke Bayindir, Sanem Nalbantgi̇l, Asli Teti̇k Vardarli
Decreased Circulating Microrna-21 And Microrna-143 Are Associated To Pulmonary Hypertension, Zekeri̇ya Düzgün, Lati̇fe Meral Kayikçioğlu, Çağdaş Aktan, Buşra Bara, Fatma Zuhal Eroğlu, Burcu Yağmur, Vi̇ldan Bozok Çeti̇ntaş, Meli̇ke Bayindir, Sanem Nalbantgi̇l, Asli Teti̇k Vardarli
Turkish Journal of Medical Sciences
Background/aim: Pulmonary arterial hypertension (PAH) is characterized by maladaptation of pulmonary vasculature which is leading to right ventricular hypertrophy and heart failure. miRNAs play a crucial role in the regulation of many diseases such as viral infection, cancer, cardiovascular diseases, and pulmonary hypertension (PH). In this study, we aimed to investigate the expression pattern of eight human plasma miRNAs (hsa-miR-21-3p, hsa-miR-143- 3p, hsa-miR-138-5p, hsa-miR-145-3p, hsa-miR-190a, hsa-miR-204-3p, hsamiR-206, hsa-miR-210-3p) in mild-to-severe PH patients and healthy controls. Materials and methods: miRNAs were extracted from the peripheral plasma of the PH patients (n: 44) and healthy individuals (n: 30) by using the miRNA …
Lag-3 Expression In Tumor Microenvironment Of Triple-Negative Breast Cancer, Gözde Tahtaci, Nazan Günel, Aysu Sadi̇oğlu, Nalan Akyürek, Oğulcan Boz, Aytuğ Üner
Lag-3 Expression In Tumor Microenvironment Of Triple-Negative Breast Cancer, Gözde Tahtaci, Nazan Günel, Aysu Sadi̇oğlu, Nalan Akyürek, Oğulcan Boz, Aytuğ Üner
Turkish Journal of Medical Sciences
Background/aim: This study aimed to evaluate the expression of lymphocyte activation gene-3 (LAG-3) and its relationship with programmed cell death ligand-1 (PD-L1) in triple-negative breast cancer (TNBC). Materials and methods: LAG-3 and PD-L1 was evaluated in tumor-infiltrating lymphocytes (TILs) using immunohistochemistry (IHC). The chi-square test was used to estimate the associations between LAG-3, PD-L1 and clinicopathological characteristics. Correlation between LAG-3 stromal TIL (sTIL), LAG-3 intraepitelial TIL (iTIL) and PD-L1 was assessed with using the Spearman's correlation coefficient. Survival analysis was performed using the Kaplan-Meier method. Results: The percentages of LAG-3 sTIL+, LAG-3 iTIL+, PD-L1+ tumor cells and PD-L1+ inflammatory cells …
Expression Of Laminin-1 And Matrix Metalloproteinase-9 In Benign And Malignant Endometrium, Zehra Küçükaydin, Mustafa Başaran, Yaşar Ünlü, Ahmet Başaran, Merti̇han Kurdoğlu
Expression Of Laminin-1 And Matrix Metalloproteinase-9 In Benign And Malignant Endometrium, Zehra Küçükaydin, Mustafa Başaran, Yaşar Ünlü, Ahmet Başaran, Merti̇han Kurdoğlu
Turkish Journal of Medical Sciences
Background/aim: Laminin-1 and matrix metalloproteinase (MMP)-9 may play roles in the progression from benign to malignant endometrium, so we aimed to investigate their levels of expression in these tissues. Materials and methods: This case-control study was conducted at a tertiary care center between January 2014 and December 2016. Paraffin blocks of 50 specimens of benign endometrium with proliferative (n = 20), secretory (n = 11), and atrophic (n = 5) endometrium; simple endometrial hyperplasia without atypia (n = 12); and endometrial polyp (n = 2) histology and 49 specimens of malignant endometrium with endometrioid (n = 40), serous (n = …
Serum Vitamin D Levels Are Associated With Acute Postoperative Pain And Opioid Analgesic Consumption After Laparoscopic Cholecystectomy: A Strobe Compliant Prospective Observational Study, Ökkeş Hakan Mi̇ni̇ksar, Ahmet Yüksek, Ayşe Yeşi̇m Göçmen, Mehmet Kağan Katar, Mahmut Kiliç, Mehtap Honca
Serum Vitamin D Levels Are Associated With Acute Postoperative Pain And Opioid Analgesic Consumption After Laparoscopic Cholecystectomy: A Strobe Compliant Prospective Observational Study, Ökkeş Hakan Mi̇ni̇ksar, Ahmet Yüksek, Ayşe Yeşi̇m Göçmen, Mehmet Kağan Katar, Mahmut Kiliç, Mehtap Honca
Turkish Journal of Medical Sciences
Background/aim: In this prospective observational study, we aimed to evaluate the relationship between serum levels of vitamin D and acute postoperative pain scores, as well as opioid analgesic consumption in patients undergoing laparoscopic cholecystectomy. Materials and methods: The study was performed in the Medical Faculty Hospital, from April 2020 to April 2021. Postoperative visual analog scale (VAS) pain scores, total tramadol consumption, number of requests on patient-controlled analgesia (PCA) were compared between the vitamin D deficient (≤20 ng/mL; n = 25) and vitamin D nondeficient (>20 ng/mL; n = 55) groups at five time points (T0: in the recovery …
Significance Of The Immunofluorescence Staining Patterns And Titres Of The Antinuclear Antibody Test In Paediatric Rheumatology Setting, Özge Baba, Hakan Kisaoğlu, Mukaddes Kalyoncu
Significance Of The Immunofluorescence Staining Patterns And Titres Of The Antinuclear Antibody Test In Paediatric Rheumatology Setting, Özge Baba, Hakan Kisaoğlu, Mukaddes Kalyoncu
Turkish Journal of Medical Sciences
Background/aim: Antinuclear antibody (ANA) is among the most frequently ordered tests in paediatric rheumatology setting. Diseases like systemic lupus erythematosus and Sjögren syndrome is closely related with a positive ANA and classified as ANA associated diseases. Besides, ANA test is ordered in patients with juvenile idiopathic arthritis (JIA) to assess the risk for uveitis and a positive ANA could be detected in children with nonrheumaticrheumatic conditions. In this study, we aimed to investigate frequency of positive ANA in paediatric rheumatology setting and the association of immunofluorescence staining patterns and titres of ANA with rheumatic diseases. Materials and methods: Immunofluorescence staining …
Psa Change After Antibiotic Treatment Should Not Affect Decision-Making On Performing A Prostate Biopsy, Yunus Kayali, Mevlana Derya Balbay, Abdullah İlktaç, Cevper Ersöz, Hüseyi̇n Toprak, Kayhan Tarim, Arzu Baygül Eden, Muzaffer Akçay, Bayram Doğan
Psa Change After Antibiotic Treatment Should Not Affect Decision-Making On Performing A Prostate Biopsy, Yunus Kayali, Mevlana Derya Balbay, Abdullah İlktaç, Cevper Ersöz, Hüseyi̇n Toprak, Kayhan Tarim, Arzu Baygül Eden, Muzaffer Akçay, Bayram Doğan
Turkish Journal of Medical Sciences
Background/aim: To investigate the effect of antibiotic treatment on PSA when deciding on prostate biopsy. Materials and methods: A total of 206 patients with an elevated PSA level (2.5-30) were included. Mp-MRI could be done on 129 patients. Patients were given ciprofloxacin (500 mg, b.i.d. p.o.) for 4 weeks and PSA measurements were repeated. Systematic prostate biopsy was performed regardless of PSA changes on all patients. Additionally, cognitive biopsies were performed from PI-RADs III, IV, and V lesions. Results: Prostate cancer was detected in 36.4% of patients. 53.3% had Gleason score of 3+3, 46.7% had Gleason score ≥ 3+4. PSA …
Determination Of The Effects Of Advanced Glycation End Products Receptor Polymorphisms And Its Activation On Structural Cell Responses And Inflammation In Asthma, Esra Bi̇rben, Ümi̇t Murat Şahi̇ner, Can Ömer Kalayci
Determination Of The Effects Of Advanced Glycation End Products Receptor Polymorphisms And Its Activation On Structural Cell Responses And Inflammation In Asthma, Esra Bi̇rben, Ümi̇t Murat Şahi̇ner, Can Ömer Kalayci
Turkish Journal of Medical Sciences
Background/aim: Advanced glycation end products receptor (RAGE) is a pattern recognition receptor which attracted attention in chronic airway diseases recently. This study aimed to determine the association of RAGE with asthma and the cellular responses resulting from RAGE signaling pathway activation. Materials and methods: Asthmatic (n = 362) and healthy (n = 134) children were genotyped by PCR-RFLP. Plasma sRAGE levels were determined by ELISA. Lung structural cells were stimulated with AGEs (advanced glycation end products) and control BSA. Expressions of cytokines and protein levels were determined by real-time PCR and ELISA. Results: Gly82Ser and -374 T/A polymorphisms in RAGE …
The Impact Of Antiphospholipid Antibodies In Takayasu Arteritis, Esra Firat Şentürk, Abdulsamet Erden, Alper Sari, Berkan Armağan, Levent Kiliç, Umut Kalyoncu, Ömer Karadağ, Şazi̇ye Şule Apraş Bi̇lgen, Sedat Ki̇raz, Ali̇ İhsan Ertenli̇, Ali̇ Akdoğan
The Impact Of Antiphospholipid Antibodies In Takayasu Arteritis, Esra Firat Şentürk, Abdulsamet Erden, Alper Sari, Berkan Armağan, Levent Kiliç, Umut Kalyoncu, Ömer Karadağ, Şazi̇ye Şule Apraş Bi̇lgen, Sedat Ki̇raz, Ali̇ İhsan Ertenli̇, Ali̇ Akdoğan
Turkish Journal of Medical Sciences
Background/aim: The significance of antiphospholipid antibodies (aPL) is controversial in Takayasu arteritis (TA). This study was conducted to explore the frequency of aPL and their association with disease-related complications in TA. Materials and methods: This cross-sectional study was conducted to investigate the presence of anti-cardiolipin (aCL), anti-beta 2 glycoprotein- 1(aß2G1) antibodies, and lupus anticoagulant (LA) in TA patients. TA patients admitted to the Department of Rheumatology of Hacettepe University Faculty of Medicine between December 2015 and September 2016 who fulfilled the American College of Rheumatology (ACR) classification criteria for TA were consecutively enrolled in the study. Patients were grouped according …
Long-Term Impact Of Sleeve Gastrectomy On Serum Uric Acid Levels, Bi̇rkan Bi̇rben, Gökhan Akkurt, Mesut Tez, Bariş Doğu Yildiz
Long-Term Impact Of Sleeve Gastrectomy On Serum Uric Acid Levels, Bi̇rkan Bi̇rben, Gökhan Akkurt, Mesut Tez, Bariş Doğu Yildiz
Turkish Journal of Medical Sciences
Background/aim: Obesity is a risk factor for hyperuricemia. Bariatric surgery is an effective treatment method for metabolic control. The aim of our study was to evaluate the correlation between the preoperative and postoperative serum uric acid levels with body mass index, body weight, and excess weight loss in patients that underwent sleeve gastrectomy. Materials and methods: A total of 164 patients that underwent laparoscopic and open sleeve gastrectomy were evaluated in terms of the demographic characteristics, preoperative body weight, body mass index and serum uric acid levels, and postoperative body weight, body mass index, excess weight loss and serum uric …
Does The Presence Of Arthroscopically Detected Stage 1-2 Glenohumeral Osteoarthritis Have Any Clinical Impact On The Outcome Of Arthroscopic Rotator Cuff Repairs?, Mehmet Ali̇ Tokgöz, Tarik Elma, Ali̇ekber Yapar, Mustafa Özer, Muhammet Baybars Ataoğlu, Ulunay Kanatli
Does The Presence Of Arthroscopically Detected Stage 1-2 Glenohumeral Osteoarthritis Have Any Clinical Impact On The Outcome Of Arthroscopic Rotator Cuff Repairs?, Mehmet Ali̇ Tokgöz, Tarik Elma, Ali̇ekber Yapar, Mustafa Özer, Muhammet Baybars Ataoğlu, Ulunay Kanatli
Turkish Journal of Medical Sciences
Background/aim: Rotator cuff rupture (RCR) and glenohumeral osteoarthritis (GHO) are two common disorders of the shoulder joint. However, there are very few reports that examine the relationship between them. This study aimed to present at least two years' clinical results of arthroscopic rotator cuff repair of full-thickness and massive tears accompanied by arthroscopically detected early-stage osteoarthritis. Materials and methods: From August 2016 to December 2017, three hundred and twenty patients with total or massive rotator cuff tears were evaluated retrospectively. Thirty-five patients who were determined as stage 1 and 2 according to the Outerbridge scale for cartilage lesions were found …
Sacral Neuromodulation Treatment For Urinary Voiding Dysfunctions: Results Of Treatment With The Largest Single-Center Series In A Tertiary Referral Center In Turkey, Mehmet Umut Kütükoğlu, Türker Altuntaş, Bahadir Şahi̇n, Ahmet Rahmi̇ Onur
Sacral Neuromodulation Treatment For Urinary Voiding Dysfunctions: Results Of Treatment With The Largest Single-Center Series In A Tertiary Referral Center In Turkey, Mehmet Umut Kütükoğlu, Türker Altuntaş, Bahadir Şahi̇n, Ahmet Rahmi̇ Onur
Turkish Journal of Medical Sciences
Background/aim: Sacral neuromodulation (SNM) is a minimally invasive treatment that modulates spinal reflexes to regulate bladder, urinary sphincter, and pelvic floor and has successfully been used in the treatment of refractory voiding dysfunctions. The aim of this study was to present our experience with SNM in a tertiary referral center with the largest number of patients and review the safety and efficacy of the procedure. Materials and methods: A total of 42 patients with refractory lower urinary tract symptoms were included into the study. After an initial test period, patients who showed more than 50% improvement in their symptoms underwent …
Cerebral Monitoring Of Very Preterm Infants With Anterior Cerebral Artery Resistive Index And Early Nirs, Mustafa Şenol Akin, Fatma Nur Sari, Burak Ceran, Davut Bozkaya, Esi̇n Okman, Mi̇hri̇ban Alkan, Evri̇m Alyamaç Di̇zdar
Cerebral Monitoring Of Very Preterm Infants With Anterior Cerebral Artery Resistive Index And Early Nirs, Mustafa Şenol Akin, Fatma Nur Sari, Burak Ceran, Davut Bozkaya, Esi̇n Okman, Mi̇hri̇ban Alkan, Evri̇m Alyamaç Di̇zdar
Turkish Journal of Medical Sciences
Background/aim: The prediction of adverse conditions in the preterm neonatal brain might be improved by cerebral monitoring using combined measures of cerebral function, including oxygenation and blood flow parameters. To perform the consecutive measurements of the resistive index (RI) from the anterior cerebral artery (ACA) within the first week of life and to evaluate the association of these measurements with cerebral oxygen saturation (Csat) detected by near-infrared spectroscopy (NIRS). Materials and methods: This prospective cohort study enrolled very preterm infants, <32 weeks of gestational age, admitted to a tertiary neonatal intensive care unit. Csat levels were continuously monitored using NIRS for 72 h after birth. ACA RI measurements were obtained on the first, third, and seventh days of life by using transcranial Doppler ultrasound. These measurements were also compared between infants with and without unfavorable outcomes, including severe intraventricular hemorrhage (IVH) and early mortality. Results: A total of 96 preterm infants with Csat and ACA RI measurements were analyzed. Age at birth was 28.3 ± 1.9 weeks and birth weight was 1090 ± 305 g. The mean Csat of the infants was 77.1% ± 8.2% during the first 72 h of life. Mean ACA RI values were 0.76 ± 0.10, 0.75 ± 0.08, and 0.77 ± 0.08 on the first, third, and seventh days of life, respectively. RI on the first day of life was significantly higher in infants delivered by cesarian section than in those delivered vaginally (0.77 vs. 0.69; p = 0.017). Infants who died earlier had significantly higher ACA RI values on the first day than infants who survived beyond the first 7 postnatal days (0.83 vs. 0.76; p < 0.001). Conclusions: There was no association between ACA RI and Csat in the early period of life. ACA RI values on the first postnatal day might be significant for predicting early mortality in very preterm infants.
Morphometric And Topographic Evaluations Of Principal Nutrient Foramina Of The Ilium, Bahatti̇n Pasli, Heli̇n Yücedağ Gündoğdu, Tuğçe Taşkindere Abbasoğlu, Burcu Erçakmak Güneş
Morphometric And Topographic Evaluations Of Principal Nutrient Foramina Of The Ilium, Bahatti̇n Pasli, Heli̇n Yücedağ Gündoğdu, Tuğçe Taşkindere Abbasoğlu, Burcu Erçakmak Güneş
Turkish Journal of Medical Sciences
Background/aim: Nutrient arteries pass through the nutrient foramina and reach the spongious part or medullary cavity of the bones. The arterial blood supply and nutrient foramina of the ilium have not been well described in the literature. The aim of this study is to define the numbers and localizations of nutrient foramina of the ilium on the internal surface in accordance with the pelvic brim, as well as the external surface, and furthermore the distances between these foramina with certain anatomical landmarks. Materials and methods: This study was performed on 57 dry hip bones. The foramina on the external and …
Cognitive Outcomes Of Transcranial Magnetic Stimulation In Treatment-Resistant Depression: A Randomized Controlled Study, Tahi̇r Yildiz, Nalan Kalkan Oğuzhanoğlu, Osman Zülki̇f Topak
Cognitive Outcomes Of Transcranial Magnetic Stimulation In Treatment-Resistant Depression: A Randomized Controlled Study, Tahi̇r Yildiz, Nalan Kalkan Oğuzhanoğlu, Osman Zülki̇f Topak
Turkish Journal of Medical Sciences
Background/aim: Major depressive disorder (MDD) is a significant cause of workforce loss, and is associated with cognitive impairments which can continue even after the elimination of mood and behavioural symptoms. The aim of this study was to investigate the benefit of transcranial magnetic stimulation (TMS) on cognitive functions in treatment resistant depression. Materials and methods: This randomised controlled clinical trial was conducted at a university hospital, department of psychiatry (tertiary centre) between October 2019 and July 2020. The study included 30 patients with depressive disorder, aged 18-50 years, who did not respond to at least two antidepressant medications for at …
Needle Electromyography Abnormalities In The Upper Trapezius Muscle In Neuromuscular Disorders, Hali̇t Fi̇danci, Şencan Buturak, İlker Öztürk, Zülfi̇kar Arlier
Needle Electromyography Abnormalities In The Upper Trapezius Muscle In Neuromuscular Disorders, Hali̇t Fi̇danci, Şencan Buturak, İlker Öztürk, Zülfi̇kar Arlier
Turkish Journal of Medical Sciences
Background/aim: Needle electromyography (EMG) abnormalities in the trapezius muscle (TM) can be seen in neuromuscular disorders. The aim was to determine the characteristics of needle EMG abnormalities observed in the TM in neuromuscular disorders. Materials and methods: The data of patients who applied to the Clinical Neurophysiology Laboratory of University of Health Sciences Adana City Training and Research Hospital between December 2018 and October 2021 were reviewed. Polio survivors, amyotrophic lateral sclerosis (ALS) patients, patients with sensorimotor polyneuropathy, patients with spinal cord lesions involving C2/C3/C4 segments, patients with spinal accessory nerve (SAN) lesions, neuralgic amyotrophy (NA) patients, and patients with …
Use Of Dual Energy Ct Urography In Evaluation Of Urinary Stone And Complex Cyst, Mehmet Gezer, Leyla Karaca, Zeynep Özdemi̇r, Ayşegül Kahraman, Fati̇h Oğuz, Mehmet Fati̇h Erbay, Hüseyi̇n Yeti̇ş
Use Of Dual Energy Ct Urography In Evaluation Of Urinary Stone And Complex Cyst, Mehmet Gezer, Leyla Karaca, Zeynep Özdemi̇r, Ayşegül Kahraman, Fati̇h Oğuz, Mehmet Fati̇h Erbay, Hüseyi̇n Yeti̇ş
Turkish Journal of Medical Sciences
Background/aim: Dual-energy computed tomography scans can provide significant benefits to the urinary system. The aim of this study is to determine the limitations and benefits of using dual energy CT urography in patients with urinary system stones and cysts. Materials and methods: In the analysis of the images, the virtual noncontrasted images obtained from the combined nephrogenicexcretory phase and the true noncontrasted images were evaluated. The true noncontrast images were accepted as the gold standard for stone detection. Results: Eighty-three different stones were detected in 26 of the 115 patients included in the study. Sensibilities of virtual noncontrast images in …