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Full-Text Articles in Medicine and Health Sciences
Awareness And Acceptability Of Monkeypox Vaccine In Men Who Have Sex With Men, Arda Karapinar, Damla Akdağ, Ayşe Deni̇z Gökengi̇n
Awareness And Acceptability Of Monkeypox Vaccine In Men Who Have Sex With Men, Arda Karapinar, Damla Akdağ, Ayşe Deni̇z Gökengi̇n
Turkish Journal of Medical Sciences
Background/aim: To determine the knowledge about and acceptance level of monkeypox vaccine in men who have sex with men (MSM). Materials and methods: A 14-item questionnaire, developed by the European Centers for Disease Control (ECDC), was presented online to MSM, aged ?18 years old, via smartphone applications (Grindr and Hornet), between June 30th and August 12th, 2022. Results: Of the 737 participants who completed the survey, 678 were born in Türkiye and 59 were migrants/visitors born in different countries. All of the participants were living in Türkiye. The median age was 31 (range 18?68) years. Overall, 21.9% were HIV-positive, 94.9% …
Dietary Inflammatory Index Score And Its Association With Body Mass Index, Body Fat Percentage, Body Fat Mass, And Lipid Profile In Patients With Multiple Sclerosis, Seda Kaya, Zeynep Uzdi̇l, Ni̇ti̇n Shi̇vappa, James R. Hebert, Pinar Sökülmez Kaya, Murat Terzi̇
Dietary Inflammatory Index Score And Its Association With Body Mass Index, Body Fat Percentage, Body Fat Mass, And Lipid Profile In Patients With Multiple Sclerosis, Seda Kaya, Zeynep Uzdi̇l, Ni̇ti̇n Shi̇vappa, James R. Hebert, Pinar Sökülmez Kaya, Murat Terzi̇
Turkish Journal of Medical Sciences
Background/aim: Multiple sclerosis (MS) may cause modifications in body composition, particularly for body fat associated with obesity and some biochemical parameters such as lipid profiles. We investigated whether there is a link between the inflammatory contents of diets and body composition and lipid profiles in patients with MS. Materials and methods: This was a cross-sectional study that included 85 MS patients. The study data of the patients were collected in the Neurology Clinic of Ondokuz Mayıs University?s Health Practice and Research Center. The data included demographic characteristics; anthropometric measurements such as body weight, height, body mass index, waist circumference, hip …
Impact Of 24-Week Dapagliflozin Treatment On Body Weight, Body Composition, And Cardiac Risk Indicators Of Patients With Type-2 Diabetes Mellitus, Pinar Akhanli, Sema Hepşen, İsmai̇l Emre Arslan, Hakan Düğer, Hayri̇ Bostan, Muhammed Kizilgül, Beki̇r Uçan, Erman Çakal
Impact Of 24-Week Dapagliflozin Treatment On Body Weight, Body Composition, And Cardiac Risk Indicators Of Patients With Type-2 Diabetes Mellitus, Pinar Akhanli, Sema Hepşen, İsmai̇l Emre Arslan, Hakan Düğer, Hayri̇ Bostan, Muhammed Kizilgül, Beki̇r Uçan, Erman Çakal
Turkish Journal of Medical Sciences
Background/aim: To reveal the impacts of dapagliflozin, a sodium glucose transporter-2 inhibitor (SGLT-2i), on body weight and body composition, cardiovascular risk indices, and carotid intima-media thickness (CIMT). Materials and methods: The data of patients with type-2 diabetes mellitus (T2DM) who applied to Department of Endocrinology and Metabolic Disorders between September 2019 and 2020, and had started dapagliflozin treatment along with their current medications were recorded retrospectively. Body weights, body compositions measured through bioelectrical impedance, and CIMT with T2DM receiving SGLT-2i treatment and medication were measured at weeks 1, 12, and 24 of 42. The visceral adiposity index (VAI), lipid accumulation …
Clinical And Laboratory Features In Health Care Volunteers With Inactivated Sars-Cov-2 Vaccination, Zhijie Li, Yafang Wan, Lanlan Xu, Wenjia Zhang, Yu Zhang, Pu Liao
Clinical And Laboratory Features In Health Care Volunteers With Inactivated Sars-Cov-2 Vaccination, Zhijie Li, Yafang Wan, Lanlan Xu, Wenjia Zhang, Yu Zhang, Pu Liao
Turkish Journal of Medical Sciences
Background/aim: To better optimize the inactivated vaccine-induced immune response and improve vaccine protection efficiency, a preliminary study was conducted on the influencing factors of producing neutralizing antibody (NAb) titers against the inactivated coronavirus disease 2019 (COVID-19) vaccine. Materials and methods: A total of 91 health care volunteers were enrolled from the Immunology Division of the Laboratory Department of Chongqing General Hospital from February to March 2021. The study had a cross-sectional design. All of the volunteers were scheduled to receive a complete dose regimen of the inactivated severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) vaccine and the vaccination interval between …
When Should A Premature Neonate (24?35 Weeks) Be Discharged? Five-Year Experience From A Single-Center Neonatal Intensive Care Unit In Türkiye, Ayşen Orman, Yalçin Çeli̇k, Semra Erdoğan
When Should A Premature Neonate (24?35 Weeks) Be Discharged? Five-Year Experience From A Single-Center Neonatal Intensive Care Unit In Türkiye, Ayşen Orman, Yalçin Çeli̇k, Semra Erdoğan
Turkish Journal of Medical Sciences
Background/aim: The survival rate among preterm infants has improved, and hospital stays have been prolonged, consistent with positive developments in perinatal and neonatal care. The aim of this study was to provide evidence-based information for healthcare professionals concerning the ideal time for discharge by evaluating the reasons for prolonged hospital stays. Materials and methods: Six hundred eighty-one premature babies born at 24?35 weeks at the Mersin University Medical Faculty Hospital between January 2016 and May 2020 and admitted to the neonatal intensive care unit were included in the study following a retrospective file examination. Date of birth (gestational age) and …
Recurrence Of Lumbar Disk Herniation After Microdiscectomy: A Two-Center Retrospective Analysis Of 1214 Cases And Identification Of Risk Factors, Bülent Gülensoy, Ebru Güzel, Müge Kuzu Kumcu, Hüseyi̇n Karasu, Serkan Şi̇mşek, Aslan Güzel
Recurrence Of Lumbar Disk Herniation After Microdiscectomy: A Two-Center Retrospective Analysis Of 1214 Cases And Identification Of Risk Factors, Bülent Gülensoy, Ebru Güzel, Müge Kuzu Kumcu, Hüseyi̇n Karasu, Serkan Şi̇mşek, Aslan Güzel
Turkish Journal of Medical Sciences
Background/aim: To present the incidence of recurrent lumbar disc herniation (RLDH) and to identify radiological and patient-related risk factors that lead to recurrence after lumbar disc herniation (LDH) treatment with microdiscectomy. Materials and methods: Between January 2013 and December 2021, 1214 patients who had undergone microdiscectomy for LDH were included in this retrospective study. Patients were divided into two groups, the recurrent group and the non-recurrent group, and their demographic, clinical and radiologic characteristics were recorded. The association between the variables and RLDH was assessed by univariate and multivariable logistic regression analyses. Results: Mean ages were similar in the recurrent …
Cupressus Arizonica: An Emerging Aeroallergen For East Mediterranean Children, Hi̇lal Ünsal, Ümi̇t Murat Şahi̇ner, Özge Uysal Soyer, Bülent Eni̇s Şekerel
Cupressus Arizonica: An Emerging Aeroallergen For East Mediterranean Children, Hi̇lal Ünsal, Ümi̇t Murat Şahi̇ner, Özge Uysal Soyer, Bülent Eni̇s Şekerel
Turkish Journal of Medical Sciences
Background/aim: Cupressus sempervirens is a tree native to the Mediterranean region. We aimed to investigate the frequency of sensitization/allergy to Cupressus arizonica pollen, which is not native to Anatolia. Materials and methods: Patients aged 5?18 years who underwent respiratory allergy screening in Türkiye?s largest referral center over a 1-year period were reviewed retrospectively for a diagnostic study of Cupressus allergy. Results: Of 246 patients, 207 (67.6% male) with a median age of 11.7 (IQR 9.2?15) years were found to be aeroallergen-sensitive and C. arizonica (32%) was the second most common sensitivity after grass pollen (83.6%). In the C. arizonica-sensitive subgroup, …
Effects Of Vitrification Solution Supplemented With Platelet-Rich Plasma In Rat Ovarian Tissue Cryopreservation, Ayli̇n Gökhan, Türker Çavuşoğlu, Kubi̇lay Doğan Kiliç, Cansin Şi̇ri̇n, Canberk Tomruk, Gürkan Yi̇ği̇ttürk, Oytun Erbaş, Eser Sözmen, Meral Baka
Effects Of Vitrification Solution Supplemented With Platelet-Rich Plasma In Rat Ovarian Tissue Cryopreservation, Ayli̇n Gökhan, Türker Çavuşoğlu, Kubi̇lay Doğan Kiliç, Cansin Şi̇ri̇n, Canberk Tomruk, Gürkan Yi̇ği̇ttürk, Oytun Erbaş, Eser Sözmen, Meral Baka
Turkish Journal of Medical Sciences
Background/aim: The subject of this study was to investigate the utility of platelet-rich plasma (PRP) in the cryopreservation process to reduce cryodamage and increase tissue viability. Materials and methods: Twenty-one female Wistar rats were randomly allocated to three groups. In Group 1 (G1), rats were not subjected to vitrification (n = 7). Group 2 (G2) was the vitrification group in which PRP was added to the basic vitrification solution (n = 7). Group 3 (G3) was the vitrification group in which fetal bovine serum was added to the basic vitrification solution (n = 7). Warmed tissues were evaluated with histochemical …
Dynamic Thiol-Disulfide Homeostasis As An Oxidative Stress Marker In Ankylosing Spondylitis And Undifferentiated Spondyloarthropathy, Cemaleddi̇n Öztürk, Şükran Erten, Murat Alişik, İsmai̇l Doğan, Güni̇z Yanik Üstüner, Sali̇m Neşeli̇oğlu, Özcan Erel
Dynamic Thiol-Disulfide Homeostasis As An Oxidative Stress Marker In Ankylosing Spondylitis And Undifferentiated Spondyloarthropathy, Cemaleddi̇n Öztürk, Şükran Erten, Murat Alişik, İsmai̇l Doğan, Güni̇z Yanik Üstüner, Sali̇m Neşeli̇oğlu, Özcan Erel
Turkish Journal of Medical Sciences
Background/aim: Seronegative spondyloarthropathies (SpA) are a group of chronic diseases characterized by axial inflammation, oligoarthritis, and enthesitis. Oxidative stress may contribute to a wide range of rheumatologic diseases, including SpA. This prospective case-control study was designed to compare thiol-disulfide levels as a marker of oxidative stress between SpA patients and healthy controls. Materials and methods: A total of 144 patients diagnosed with undifferentiated spondyloarthropathy (USpA, n = 97) or ankylosing spondylitis (AS, n = 47) were included along with 80 healthy controls. Serum native thiol (NT), total thiol (TT), and disulfide (D) levels were measured using the fully automated Erel …
Evaluation Of Vitamin D Levels And Biochemical Markers In Infants Diagnosed With Laryngomalacia, Nagi̇han Bi̇lal, Ömer Faruk Çinar, Sevcan İpek, Muhammed Seyi̇thanoğlu, Adem Doğaner, Muhammed Gazi̇ Yildiz
Evaluation Of Vitamin D Levels And Biochemical Markers In Infants Diagnosed With Laryngomalacia, Nagi̇han Bi̇lal, Ömer Faruk Çinar, Sevcan İpek, Muhammed Seyi̇thanoğlu, Adem Doğaner, Muhammed Gazi̇ Yildiz
Turkish Journal of Medical Sciences
Background/aim: The pathology of laryngomalacia is still not clear. The aim of this study was to investigate the relationship between vitamin D levels and laryngomalacia, and to evaluate vitamin D levels according to the classification of laryngomalacia. Materials and methods: This retrospective study was conducted in the Kahramanmaraş Sütçü İmam University Medicine Faculty?s Otorhinolaryngology Clinic between June 2014 and January 2021. Laryngomalacia was classified. Laboratory tests for all patients included calcium (Ca), phosphorus (P), parathormone (PTH), blood urea nitrogen (BUN), creatinine (Cre), alanine transaminase (ALT), and 25-hydroxy vitamin D (25-OH-D). Results: Evaluations were performed for 64 infants with laryngomalacia, including …
The Press-Fit Technique Without Screws And Bone Graft Can Be Used As An Alternative Method In Crowe Type Ii And Iii Hip Dysplasia, Azi̇z Çataltepe, Yusuf İyeti̇n
The Press-Fit Technique Without Screws And Bone Graft Can Be Used As An Alternative Method In Crowe Type Ii And Iii Hip Dysplasia, Azi̇z Çataltepe, Yusuf İyeti̇n
Turkish Journal of Medical Sciences
Background/aim: Developmental dysplasia of the hip (DDH) is the most common cause of secondary hip arthrosis. The primary purpose of this study was to assess the results of an oversized hemispherical cup via the press-fit technique used for Crowe type II and III DDH without screws and to determine if adequate medialization and initial stability of the acetabular component would allow us to avoid screw and graft use. Materials and methods: Between February 2012 and May 2020, the current study analyzed 43 hips with Crowe type II and III DDH treated with a porous-coated cup by placing the press-fit technique …
Acetone Extracts Of Berberis Vulgaris And Cornus Mas L. Induce Apoptosis In Mcf-7 Breast Cancer Cells, Burcu Uslu, Mustafa Yaman, Tuba Özdemi̇r Sanci, Mustafa Güngörmüş, Çağla Zübeyde Köprü, Fatma Esra Güneş
Acetone Extracts Of Berberis Vulgaris And Cornus Mas L. Induce Apoptosis In Mcf-7 Breast Cancer Cells, Burcu Uslu, Mustafa Yaman, Tuba Özdemi̇r Sanci, Mustafa Güngörmüş, Çağla Zübeyde Köprü, Fatma Esra Güneş
Turkish Journal of Medical Sciences
Background/aim: This study aimed to determine the proliferation and apoptotic effects of extracts from Cornus mas L. and Berberis vulgaris fruits on human breast cancer cells (MCF-7). Materials and methods: The Cornus mas L. and Berberis vulgaris fruits, which constitute the herbal material of the study, were turned into 80% acetone extract after washing. The total phenolic content in Berberis vulgaris fruit extracts was determined calorimetrically using Folin-Ciocalteu reagent. The spectrophotometric method was used to determine the total flavonoid amount of the extracts. In order to measure the antioxidant capacity of Cornus mas L. and Berberis vulgaris fruits and extracts, …
Serum Myosin-Binding Protein C Levels: A New Marker For Exclusion Of Preterm Birth?, Eli̇f Yildiz, Fatma Ketenci̇ Gencer, Burcu Ti̇mur, Hakan Ti̇mur
Serum Myosin-Binding Protein C Levels: A New Marker For Exclusion Of Preterm Birth?, Eli̇f Yildiz, Fatma Ketenci̇ Gencer, Burcu Ti̇mur, Hakan Ti̇mur
Turkish Journal of Medical Sciences
Background/aim: To evaluate whether there is a relationship between serum myosin-binding protein C (MyBP-C) levels measured in the first trimester and the timing of delivery, and, if a relationship is detected, the potential of this relationship in distinguishing between preterm and term labor. Materials and methods: This prospective case-control study was conducted with 701 pregnant women who applied to the Obstetrics Outpatient Clinic of Gaziosmanpaşa Training and Research Hospital in the first trimester, between 11 and 14 gestational weeks. MyBP-C serum samples from the first trimester were stored under appropriate conditions until the time of delivery. Of these pregnant women, …
A Retrospective Study: Can Dual Art Mitigate The Risk Of Potential Drug-Drug Interactions Among Plwh Under Stable Art?, Ahmet Çağkan İnkaya, Fatma Ni̇sa Balli, Emre Kara, Sali̇h Kutay Demi̇rkan, Serhat Ünal
A Retrospective Study: Can Dual Art Mitigate The Risk Of Potential Drug-Drug Interactions Among Plwh Under Stable Art?, Ahmet Çağkan İnkaya, Fatma Ni̇sa Balli, Emre Kara, Sali̇h Kutay Demi̇rkan, Serhat Ünal
Turkish Journal of Medical Sciences
Background/aim: People living with human immunodeficiency virus (PLWH) are getting older. Age-related comorbidities in PLWH result in polypharmacy and increase the risk for potential drug-drug interactions (pDDIs). This study aimed to evaluate how the rate of pDDIs would change if the treatment of patients receiving different combined antiretroviral therapies (ARTs) were theoretically changed with dolutegravir/lamivudine (DTG+3TC) or cabotegravir/rilpivirine (CAB+RPV). Materials and methods: This study was conducted at the infectious disease outpatient clinic of a university hospital as a follow-up of a previous study. The data of PLWH receiving at least 1 comedication other than antiretrovirals (ARVs) were retrospectively reviewed and …
Postauricular Linear Basal Cell Carcinomas Related To Medical Mask Cords: A Possible Association, Bengü Ni̇sa Akay, Di̇lan Kizilirmak, Aylin Heper
Postauricular Linear Basal Cell Carcinomas Related To Medical Mask Cords: A Possible Association, Bengü Ni̇sa Akay, Di̇lan Kizilirmak, Aylin Heper
Turkish Journal of Medical Sciences
Linear basal cell carcinoma (BCC) is a distinct clinical morphological variant of BCC. Although it has been speculated that trauma and the Koebner phenomenon may be linked to linear BCC, the pathophysiology has not yet been shown. Herein, 5 cases of BCC were presented that developed in the postauricular region as a result of trauma caused by the cords of the medical face masks worn during the COVID-19 pandemic.
Unraveling The Impact Of Primary Immunodeficiency Disorders On The Microbiota Of Dental Caries In Children Through 16s Rrna Gene-Based Metagenomic Analysis, Bushra Al-Kebsi̇, Gökhan Kars, Hazal Özer, Şükrü Nai̇l Güner
Unraveling The Impact Of Primary Immunodeficiency Disorders On The Microbiota Of Dental Caries In Children Through 16s Rrna Gene-Based Metagenomic Analysis, Bushra Al-Kebsi̇, Gökhan Kars, Hazal Özer, Şükrü Nai̇l Güner
Turkish Journal of Medical Sciences
Background/aim: Dental caries is a frequently occurring and multifactorial chronic disease in children resulting from the interaction of cariogenic bacteria and host susceptibility. The aim of this study was to elucidate the impacts of primary immunodeficiency disorders (PIDs) on microbiota of dental caries in children by 16S rRNA gene-based metagenomic analysis. Materials and methods: Enrolled in this study were 15 children with primary PID with caries (PID group) and 15 healthy children with caries as a control (CG). The DMFT index, saliva flow rate, and buffering capacity of each participant were assessed before the metagenomic analyses were conducted. For taxonomic …
Is The Pediatric Eosinophilic Esophagitis Symptom Score V2.0 Reliable For Telemedicine?, Si̇nem Polat Terece, Di̇lek Yapar, Hacer İlbi̇lge Ertoy Karagöl, Gi̇zem Köken, Demet Teker Düztaş, Ödül Eğri̇taş, Si̇nan Sari, Buket Dalgiç, Arzu Bakirtaş
Is The Pediatric Eosinophilic Esophagitis Symptom Score V2.0 Reliable For Telemedicine?, Si̇nem Polat Terece, Di̇lek Yapar, Hacer İlbi̇lge Ertoy Karagöl, Gi̇zem Köken, Demet Teker Düztaş, Ödül Eğri̇taş, Si̇nan Sari, Buket Dalgiç, Arzu Bakirtaş
Turkish Journal of Medical Sciences
Background/aim: Eosinophilic esophagitis (EoE) is a chronic immune-mediated disease. Telemedicine is a healthcare technology used when a patient is separated by distance. The reliability of the Pediatric Eosinophilic Esophagitis Symptom Score, version 2.0 (PEESS v2.0) for telemedicine applications, has not been studied yet. Therefore, we aimed to evaluate the reliability of PEESS v2.0 for telemedicine. Materials and methods: We sent a telesurvey using questionnaires via electronic telecommunication as the telemedicine method. Children with EoE and their parents were asked to complete PEESS v2.0 with the telesurvey method (unsynchronized with the physician) and attend in-person visits one week apart. Intraclass correlation …
The Importance Of Skin Prick Test In Differentiating Cat Sensitivities And Allergies In Children, Mehmet Şi̇ri̇n Kaya, Özge Atay, İdi̇l Akay Haci, İlke Taşkirdi, Seli̇me Özen Bölük, Fi̇gen Çelebi̇ Çeli̇k, Özgen Soyöz, Canan Şule Ünsal Karkiner, Demet Can
The Importance Of Skin Prick Test In Differentiating Cat Sensitivities And Allergies In Children, Mehmet Şi̇ri̇n Kaya, Özge Atay, İdi̇l Akay Haci, İlke Taşkirdi, Seli̇me Özen Bölük, Fi̇gen Çelebi̇ Çeli̇k, Özgen Soyöz, Canan Şule Ünsal Karkiner, Demet Can
Turkish Journal of Medical Sciences
Background/aim: The incidence of cat allergies in children has increased over the years. Children with cat allergies have mostly reported respiratory symptoms. The skin prick test (SPT) is the most preferred method to demonstrate sensitization to allergens. However, not all children who develop cat sensitization due to environmental exposure become allergic to cats. In our study, we aimed to determine the frequency of sensitization to cat and cat allergy, cat-related symptoms, and the cut-off value for the SPT that may indicate cat allergy. Materials and methods: Patients aged 2-18 years, who applied to the Health Sciences University İzmir Dr Behçet …
The Role Of Curcumin On Apoptosis And Nlrp3 Inflammasome-Dependent Pyroptosis On Colorectal Cancer In Vitro, Zeynep Dal, Başak Aru
The Role Of Curcumin On Apoptosis And Nlrp3 Inflammasome-Dependent Pyroptosis On Colorectal Cancer In Vitro, Zeynep Dal, Başak Aru
Turkish Journal of Medical Sciences
Background/aim: Colorectal cancer (CRC) is one of the most common cancers worldwide. Many factors such as stress, lifestyle, and dietary habits are known to play a role in the initiation and progression of the disease. Herbal therapeutic agents including curcumin can hold a great potential against cancer treatment; however, their efficacy on CRC is still under investigation. Herein, we evaluated the anticancer mechanism of curcumin on four different CRC cell lines. Materials and methods: Cells were treated with curcumin for 24, 48 and 72 h, and IC50 doses for each cell line were calculated. Mechanistic studies were conducted with the …
Effects Of Thymoquinone And Memantine Alone And In Combination On Memory And Hippocampal Morphology In Rats With Streptozotocin-Induced Alzheimer's Disease, Şeyma Özsoy, Zi̇ya Çakir, Eli̇f Akçay, Fi̇kret Gevrek
Effects Of Thymoquinone And Memantine Alone And In Combination On Memory And Hippocampal Morphology In Rats With Streptozotocin-Induced Alzheimer's Disease, Şeyma Özsoy, Zi̇ya Çakir, Eli̇f Akçay, Fi̇kret Gevrek
Turkish Journal of Medical Sciences
Background/aim: Alzheimer's disease (AD) is a progressive neurodegenerative disease. Thymoquinone (TQ) has broad biological functions, including antiinflammatory, antioxidant, neuroprotective properties. Memantine (MEM) is indicated for the symptomatic treatment of moderate to severe AD. We aimed to evaluate the effect of TQ alone or in combination with MEM on memory and hippocampal morphology in an STZ-induced rat AD model. Materials and methods: Thirty male rats were included in this study. The AD model was created by giving ICV STZ. The rats were divided into 5 groups (n = 6 each). Group 1 (control group): The rats received only ICV-STZ 3 mg/kg …
Radioprotective Effects Of Melatonin And Thymoquinone On Liver, Parotid Gland, Brain, And Testis Of Rats Exposed To Total Body Irradiation, Mehmet Koç, Çi̇ğdem Damla Deni̇z, Mehmet Aki̇f Eryilmaz, Yilmaz Tezcan, Mehmet Gürbi̇lek
Radioprotective Effects Of Melatonin And Thymoquinone On Liver, Parotid Gland, Brain, And Testis Of Rats Exposed To Total Body Irradiation, Mehmet Koç, Çi̇ğdem Damla Deni̇z, Mehmet Aki̇f Eryilmaz, Yilmaz Tezcan, Mehmet Gürbi̇lek
Turkish Journal of Medical Sciences
Background/aim: This study aimed to investigate thymoquinone (TQ), and melatonin's radioprotective effects on liver, parotid gland, brain, and testis of rats which were exposed to total body irradiation (IR). Materials and methods: Thirty adult Wistar rats were randomly divided into four groups that are Group 1 (control group): total body IR only, Group 2: IR-Melatonin (10 mg/kg), Group 3: IR-TQ (10 mg/kg), and Group 4 (sham group): nothing. Total body IR dose was 6 Gy. Tissue samples were taken 90 min after IR. The measurements of malondialdehyde (MDA), glutathione peroxidase (GSH-Px), and superoxide dismutase (SOD) were performed in all groups. …
Melanocytic Tumors With Spitzoid Morphology: Correlation Of Clinicopathologic Features And Fish Analysis, Deni̇z Ünlüer Kapişkay, Övgü Aydin Ülgen, Ümi̇t İnce, Cüyan Demi̇rkesen
Melanocytic Tumors With Spitzoid Morphology: Correlation Of Clinicopathologic Features And Fish Analysis, Deni̇z Ünlüer Kapişkay, Övgü Aydin Ülgen, Ümi̇t İnce, Cüyan Demi̇rkesen
Turkish Journal of Medical Sciences
Background/aim: A subset of melanocytic tumors with spitzoid morphology may lead to potential inaccurate diagnosis and lack of assessment of malignancy potential. In this study, we aimed to evaluate melanocytic tumors with spitzoid morphology using conventional melanoma FISH (RREB-1, CCND1, MYB and CEP6) and 9p21 FISH (CDKN2A) probes and compare the probe results with clinical and histopathological features. Materials and methods: This study is a multicentric retrospective study including three centers, İstanbul University-Cerrahpaşa, Cerrahpaşa School of Medicine, Department of Pathology, Acıbadem University, School of Medicine, Department of Pathology and ETA Pathology Laboratory. The pathology reports in archives of these three …
Evaluation Of Local And Systemic Side Effects Of Turkovac Vaccine In Adults, Bülent Nuri̇ Kalayci, Doğu Karahan
Evaluation Of Local And Systemic Side Effects Of Turkovac Vaccine In Adults, Bülent Nuri̇ Kalayci, Doğu Karahan
Turkish Journal of Medical Sciences
Background/aim: COVID-19 is a respiratory disease that caused a pandemic after reportedly emerging from Wuhan, China, in December 2019. Different types of COVID-19 vaccines such as viral vectors, mRNA, and inactivated vaccines have been produced since the beginning of the pandemic. Turkovac is an inactive COVID-19 vaccine developed and produced in Türkiye. We conducted our study to investigate the local and systemic side effects of the Turkovac vaccine. Materials and methods: A cross-sectional survey-based study was conducted to collect data on the postvaccine side effects in people aged over 18 who were vaccinated with Turkovac, between March and June 2022, …
Survival Outcomes Of Patients With Oligometastatic Non-Small Cell Lung Cancer Who Were Treated With Radical Therapy: A Multicenter Analysis, Özgür Açikgöz, Ahmet Bi̇li̇ci̇, Deni̇z Tataroğlu Özyükseler, Sabi̇n Göktaş Aydin, Fati̇h Selçukbi̇ri̇ci̇k, Rashad Rzazade, Ömer Fati̇h Ölmez, Hale Başak Çağlar
Survival Outcomes Of Patients With Oligometastatic Non-Small Cell Lung Cancer Who Were Treated With Radical Therapy: A Multicenter Analysis, Özgür Açikgöz, Ahmet Bi̇li̇ci̇, Deni̇z Tataroğlu Özyükseler, Sabi̇n Göktaş Aydin, Fati̇h Selçukbi̇ri̇ci̇k, Rashad Rzazade, Ömer Fati̇h Ölmez, Hale Başak Çağlar
Turkish Journal of Medical Sciences
Background/aim: Oligometastatic disease for nonsmall cell lung cancer (NSCLC) patients is generally thought to represent a better prognosis with a quieter biology, limited number of disease sites and long-term disease control. In this study, we aimed to determine the efficacy of radical treatment options for patients with oligometastatic NSCLC. Materials and methods: This retrospective trial included totally 134 patients with oligometastatic NSCLC. The presence of oncodriver mutation, tumor stages and nodal status, the number of metastases and involved metastatic site, treatment of primary tumor and oligometastasis, response rate, overall survival (OS) and progression-free survival (PFS) were evaluated. Results: Of 134 …
Retrospective Analysis Of Children Diagnosed With Kawasaki Disease, Fati̇h Varol, Reyhan Dedeoğlu, Azi̇z Kiliç, Murat Tuğberk Bakar, Amra Adrovi̇c, Sezgi̇n Şahi̇n, Mehmet Yildiz, Kenan Barut, Hali̇t Çam, Özgür Kasapçopur
Retrospective Analysis Of Children Diagnosed With Kawasaki Disease, Fati̇h Varol, Reyhan Dedeoğlu, Azi̇z Kiliç, Murat Tuğberk Bakar, Amra Adrovi̇c, Sezgi̇n Şahi̇n, Mehmet Yildiz, Kenan Barut, Hali̇t Çam, Özgür Kasapçopur
Turkish Journal of Medical Sciences
Background/aim:The aim of our study was to evaluate the long-term impacts of Kawasaki disease on our patients regarding coronary involvement demographic characteristics, treatment regimens, and clinical course. Materials and methods: Our study included 104 patients diagnosed and hospitalized with Kawasaki disease in our center, from January 2004 to January 2019. In our study, patients were divided into three groups according to coronary artery involvement. Patients in group 1 had no echocardiographic findings, while the ones in group 2 had coronary artery dilatation and ones in group 3 had coronary artery aneurysm (CAA). Results:Among 104 patients, the median age was 9.15 …
Initial Alpha-1 Antitrypsin Screening In Turkish Patients With Chronic Obstructive Pulmonary Disease, Seda Tural Önür
Initial Alpha-1 Antitrypsin Screening In Turkish Patients With Chronic Obstructive Pulmonary Disease, Seda Tural Önür
Turkish Journal of Medical Sciences
Background/aim: Alpha-1 antitrypsin (AAT) deficiency is associated with several types of pathology, and the reported effects of mutations in the ATT-encoding gene vary worldwide. No Turkish study has yet appeared. We thus explored the AAT status of Turkish patients with chronic obstructive pulmonary disease (COPD). Materials and methods: This prospective cross-sectional study included outpatients and inpatients treated from June 2021 to June 2022. Serum AAT levels were checked, and dry blood samples were subjected to genetic analysis. Results: Genetic mutations were found in 21 (3.52%) of 596 patients with prior and new COPD diagnoses treated in our pneumonology outpatient department. …
In Vitro Hepatotoxicity Evaluation Of Methotrexate-Loaded Niosome Formulation: Fabrication, Characterization And Cell Culture Studies, Ahmet Doğan Ergi̇n, Çağatay Oltulu, Nebi̇ye Peli̇n Türker, Gülen Meli̇ke Demi̇rbolat
In Vitro Hepatotoxicity Evaluation Of Methotrexate-Loaded Niosome Formulation: Fabrication, Characterization And Cell Culture Studies, Ahmet Doğan Ergi̇n, Çağatay Oltulu, Nebi̇ye Peli̇n Türker, Gülen Meli̇ke Demi̇rbolat
Turkish Journal of Medical Sciences
Background/aim: Methotrexate (MTX) is a folic acid antagonist that is widely used to treat osteosarcoma, leukemia, breast cancer, and autoimmune and inflammatory diseases. The most important concerns with MTX are its poor solubility and high toxicity, particularly in liver cells. To enhance its solubility and to minimize its toxicity, we encapsulated MTX in niosomes and investigated its hepatotoxicity mechanisms using genetic biomarkers. Materials and methods: Niosomes were successfully prepared using a modified thin film method, and the prepared monodisperse smallsized formulation was subsequently characterized. In vitro cytotoxicity studies were performed both in hepatocarcinoma (HEP3G) and healthy liver (AML12) cell lines. …
Zero Ischemia Robotic Partial Nephrectomy: Oncological And Functional Outcomes Of A Multicenter Study, Kemal Ener, Abdullah Erdem Canda, Murat Bi̇nbay, Mevlana Derya Balbay, Ali̇ Fuat Atmaca
Zero Ischemia Robotic Partial Nephrectomy: Oncological And Functional Outcomes Of A Multicenter Study, Kemal Ener, Abdullah Erdem Canda, Murat Bi̇nbay, Mevlana Derya Balbay, Ali̇ Fuat Atmaca
Turkish Journal of Medical Sciences
Background/aim: The functional and oncological outcomes of zero ischemia robotic partial nephrectomy (RPN) procedures were evaluated. Materials and methods: A total of 56 patients underwent zero ischemia RPN transperitoneally, and their data were collected prospectively. Radius, exo/endophytic, nearness, anterior/posterior, location (R.E.N.A.L.) nephrometry, and PADUA scores were calculated. Patient and tumor characteristics were evaluated. Intra- and perioperative (0-30 days) complications were evaluated by Clavien classification. The change in serum creatinine, and estimated glomerular filtration rates (eGFR) were evaluated during preoperative, immediate postoperative periods, and at postoperative 6th months. Results: The mean age of the patients was 52.2 ± 8.1 (27-75) years. …
Is Cancer Risk Reduced In Multiple Sclerosis? Results From A Tertiary Referral Center, Yasemi̇n Bahar, Egemen Yildiz, Abdul Rasheed Bahar, Rana Karabudak
Is Cancer Risk Reduced In Multiple Sclerosis? Results From A Tertiary Referral Center, Yasemi̇n Bahar, Egemen Yildiz, Abdul Rasheed Bahar, Rana Karabudak
Turkish Journal of Medical Sciences
Background/aim: Multiple sclerosis (MS) patients may be protected against cancer because of increased immune surveillance. However, aberrant T/B cell functioning in MS may increase the risk of cancer. We aimed to compare the frequency of cancer among patients with MS with an appropriate control group matched by the variables such as age, gender, tobacco smoking history, body mass index (BMI), and family history of cancer. Materials and methods: The MS patients who were registered and followed up at the MS Center in Hacettepe University Hospitals and appropriately matched with controls were included. A self-administered questionnaire with links to the online …
Emergency Ultrasound Of Respiratory Muscles: A Promising Tool For Determining The Outcomes Of Copd Exacerbations, Di̇nçer Yegi̇n, Alten Oskay, Tülay Oskay, Selcan Enver Di̇nç, Hande Şenol, Mert Özen, Vefa Çakmak, Murat Seyi̇t, Atakan Yilmaz, İbrahi̇m Türkçüer
Emergency Ultrasound Of Respiratory Muscles: A Promising Tool For Determining The Outcomes Of Copd Exacerbations, Di̇nçer Yegi̇n, Alten Oskay, Tülay Oskay, Selcan Enver Di̇nç, Hande Şenol, Mert Özen, Vefa Çakmak, Murat Seyi̇t, Atakan Yilmaz, İbrahi̇m Türkçüer
Turkish Journal of Medical Sciences
Background/aim: The respiratory muscles of patients with chronic obstructive pulmonary disease (COPD) exhibit structural and functional changes that can be evaluated and monitored by ultrasonography. Materials and methods: This single-center, prospective study was conducted in the emergency department (ED) of a tertiary care hospital over an eight-month period (September 2020-May 2021). Diaphragmatic excursions, end-expiratory thickness, and thickening fractions, as well as right and left intercostal muscle thicknesses, of all adult subjects manifesting COPD exacerbation, were assessed. The data were analyzed regarding ward/intensive care unit (ICU) hospitalization or discharge from the ED, mortality, and readmission within 15 days. Results: Sixty-three subjects …