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Articles 481 - 510 of 4871
Full-Text Articles in Medicine and Health Sciences
Validity And Reliability Study Of The Quality Of Recovery Scale In Turkish, Ümmühan Kiliç, Di̇lek Kiymaz, Esra Saraçoğlu, Bahadir Yazicioğlu
Validity And Reliability Study Of The Quality Of Recovery Scale In Turkish, Ümmühan Kiliç, Di̇lek Kiymaz, Esra Saraçoğlu, Bahadir Yazicioğlu
Turkish Journal of Medical Sciences
Background/aim: The aim of this study was to adapt the ?Quality of Recovery-15 Scale?, developed to measure the postoperative recovery quality of individuals, into Turkish by carrying out validity and reliability studies. Materials and methods: This methodological study was conducted with a total of 150 patients who underwent surgery under general anesthesia between November 2021 and January 2022 in a training and research hospital in the Black Sea region. Data was collected from the patients through the face-to-face interview method before the operation, on the 24th and the 48th hour postoperatively. First, the linguistic validity of the scale and then …
Effects Of Progressive Functional Ankle Exercises In Spastic Cerebral Palsy, Plantarflexors Versus Dorsiflexors: A Randomized Trial, Melek Volkan Yazici, Gamze Çobanoğlu, Gökhan Yazici, Bülent Elbasan
Effects Of Progressive Functional Ankle Exercises In Spastic Cerebral Palsy, Plantarflexors Versus Dorsiflexors: A Randomized Trial, Melek Volkan Yazici, Gamze Çobanoğlu, Gökhan Yazici, Bülent Elbasan
Turkish Journal of Medical Sciences
Background/aim: Children with cerebral palsy (CP), even those who have very mild impairment, have lower muscle strength than their typically developing peers. The ankle dorsiflexors (DFs) and plantarflexors (PFs) of children with CP are especially weak. Weakness in the ankle muscles causes problems in functional skills, mobility, and balance in spastic CP (SCP). The aim of this study was to investigate the effects of progressive functional exercises (PFEs) on the DF, PF, or dorsi-plantar flexor (DPF) muscles in children with SCP, specifically, the functional mobility, balance, and maximum voluntary contraction (MVC), and compare the effects of strengthening these muscles individually …
Pathobiological Alterations Affecting The Distinct Clinical Courses Of Pediatric Versus Adult Covid-19 Syndrome, Emrah Şenel, Seyhan Türk, Ümi̇t Yavuz Malkan, Mustafa Çağri Peker, Can Türk, Hati̇ce Rahmet Güner, Gülberk Uçar, Seval İzdeş, Bi̇rcan Kayaaslan, Gülsüm İclal Bayhan, Serhat Emeksi̇z, İmran Hasanoğlu, Şeri̇fe Gökbulut Bektaş, Şeyma Bütün Türk, Serhan Özcan
Pathobiological Alterations Affecting The Distinct Clinical Courses Of Pediatric Versus Adult Covid-19 Syndrome, Emrah Şenel, Seyhan Türk, Ümi̇t Yavuz Malkan, Mustafa Çağri Peker, Can Türk, Hati̇ce Rahmet Güner, Gülberk Uçar, Seval İzdeş, Bi̇rcan Kayaaslan, Gülsüm İclal Bayhan, Serhat Emeksi̇z, İmran Hasanoğlu, Şeri̇fe Gökbulut Bektaş, Şeyma Bütün Türk, Serhan Özcan
Turkish Journal of Medical Sciences
Background/aim: The clinical presentation of pediatric coronavirus disease 2019 (COVID-19) is associated with a milder disease course than the adult COVID-19 syndrome. The disease course of COVID-19 has three clinicobiological phases: initiation, propagation, and complication. This study aimed to assess the pathobiological alterations affecting the distinct clinical courses of COVID-19 in pediatric age groups versus the adult population. We hypothesized that critical biogenomic marker expressions drive the mild clinical presentations of pediatric COVID-19. Materials and methods: Blood samples were obtained from 72 patients with COVID-19 hospitalized at Ankara City Hospital between March and July 2021. Peripheral blood mononuclear cells were …
Which Sequence Should Be Used In The Thorax Magnetic Resonance Imaging Of Covid-19: A Comparative Study, Ayşe Şule Ateş, Burak Yağdiran, Onur Taydaş, Ömer Faruk Ateş
Which Sequence Should Be Used In The Thorax Magnetic Resonance Imaging Of Covid-19: A Comparative Study, Ayşe Şule Ateş, Burak Yağdiran, Onur Taydaş, Ömer Faruk Ateş
Turkish Journal of Medical Sciences
Background and aim: To evaluate and compare magnetic resonance imaging (MRI) sequences that could potentially be used in the diagnosis of coronavirus disease 2019 (COVID-19). Materials and methods: Included in the study were 42 patient who underwent thorax computed tomography (CT) for COVID-19 pneumonia and thorax MRI for any reason within 24 h after CT. The T2-weighted fast spin echo periodically rotated overlapping parallel lines with enhanced reconstruction (PROPELLER) (T2W-FSE-P), fast imaging employing steady-state acquisition, T2 fat-saturated FSE, axial T1 liver acquisition with volume acceleration (LAVA) and single-shot FSE images were compared in terms of their ability to show COVID-19 …
Novel Parameters For Predicting Fluid Responsiveness During The Mini Fluid Challenge And Ability Of The Cardiac Power Index: An Observational Cohort Study, Taner Abdullah, Hürü Ceren Gökduman, İşbara Alp Eni̇şte, Ayşe Gülşah Atasever, Achmet Ali, Funda Gümüş Özcan
Novel Parameters For Predicting Fluid Responsiveness During The Mini Fluid Challenge And Ability Of The Cardiac Power Index: An Observational Cohort Study, Taner Abdullah, Hürü Ceren Gökduman, İşbara Alp Eni̇şte, Ayşe Gülşah Atasever, Achmet Ali, Funda Gümüş Özcan
Turkish Journal of Medical Sciences
Background/aim: The percentage change in the stroke volume index (SVI) due to the mini fluid challenge (MFC) (MFC-?SVI%) is used commonly in daily practice. However, up to 20% of patients remain in the gray zone of this variable. Thus, it was aimed to compare the MFC-?SVI% and the percentage change in the cardiac power index (CPI) due to the MFC (MFC-?CPI%) with the baseline values of the pulse pressure variation (PPV) and stroke volume variation (SVV) in terms of their abilities to predict fluid responsiveness. Materials and methods: The SVI, CPI, SVV, and PPV were recorded before 100 mL of …
Investigating The Physiological Role Of S199a And S199d Mutants Of Phf6 Protein In T-Cell Acute Lymphoblastic Leukemia, Gökçe Erdoğan, Osman Ni̇dai̇ Özeş, Osman Alphan Küpesi̇z, Şükran Burçak Yoldaş
Investigating The Physiological Role Of S199a And S199d Mutants Of Phf6 Protein In T-Cell Acute Lymphoblastic Leukemia, Gökçe Erdoğan, Osman Ni̇dai̇ Özeş, Osman Alphan Küpesi̇z, Şükran Burçak Yoldaş
Turkish Journal of Medical Sciences
Background/aim: T-cell acute lymphoblastic leukemia (T-ALL) is a form of leukemia characterized by the proliferation of immature T lymphocytes. NOTCH1 is one of the most frequently mutated genes in T-ALL. NOTCH1 expression in T-cell development depends on plant homeodomain finger protein 6 (PHF6), which plays a tumor suppressor role in T-ALL. Several studies have shown that PHF6 expression is essential for NOTCH1 expression. Therefore, whether posttranslational modification of PHF6 plays a role in the regulation of NOTCH1 expression and T-ALL cell line proliferation was investigated herein. Materials and methods: The amino acid sequence of PHF6 was analyzed and it was …
Serum Amylase On Postoperative Day One Is A Strong Predictor Of Pancreatic Fistula After Pancreaticoduodenectomy: A Retrospective Cohort, Oğuzhan Özşay, Mehmet Can Aydin, Sali̇h Can Çeli̇k, Kağan Karabulut, Sai̇m Savaş Yürüker
Serum Amylase On Postoperative Day One Is A Strong Predictor Of Pancreatic Fistula After Pancreaticoduodenectomy: A Retrospective Cohort, Oğuzhan Özşay, Mehmet Can Aydin, Sali̇h Can Çeli̇k, Kağan Karabulut, Sai̇m Savaş Yürüker
Turkish Journal of Medical Sciences
Background/aim: Early identification of patients at risk for developing postoperative pancreatic fistula (POPF) after pancreaticoduodenectomy (PD) may facilitate drain management. In this context, it was aimed to examine the efficiency of the serum amylase (SA) value on postoperative day (PoD) 1 in predicting the occurrence of POPF. Materials and methods: A total of 132 patients who underwent PD were studied. Occurrences of POPF were classified according to the International Study Group on Pancreatic Fistula classification as a biochemical leak (BL) or clinically relevant grade b/c POPF (CRPOPF). Receiver operating characteristic analysis identified a threshold value of SA on PoD 1 …
Evaluation Of Diaphragm Functions With Diaphragm Ultrasound And Pulmonary Function Tests In Individuals With Friedreich?S Ataxia, Nur Aleyna Yetki̇n, Mehmet Fati̇h Yetki̇n, Burcu Baran Ketenci̇oğlu, Fatma Sema Oymak, İnci̇ Gülmez, İnsu Yilmaz, Nuri̇ Tutar
Evaluation Of Diaphragm Functions With Diaphragm Ultrasound And Pulmonary Function Tests In Individuals With Friedreich?S Ataxia, Nur Aleyna Yetki̇n, Mehmet Fati̇h Yetki̇n, Burcu Baran Ketenci̇oğlu, Fatma Sema Oymak, İnci̇ Gülmez, İnsu Yilmaz, Nuri̇ Tutar
Turkish Journal of Medical Sciences
Background/aim: It is known that the correlation of pulmonary function tests (PFT) with muscle dysfunction is insufficient. Here, we aimed to evaluate the diaphragm functions in individuals with Friedreich?s ataxia (FRDA) and to examine its relationship with respiratory parameters and disease severity. Materials and methods: This prospective study, conducted between November and December 2022, at Erciyes University, included 14 individuals with genetically confirmed FRDA and an age- and gender-matched healthy control group of eight individuals. We examined pulmonary functions with spirometric methods and evaluated diaphragm excursion, and diaphragm thickness-expiratory (Tde) and ? end of inspiration (Tdi) with ultrasonography during calm …
Evaluation Of Syringin?S Neuroprotective Effect In A Model Of Neonatal Hypoxic-Ischemic Brain Injury, Ezgi̇ Yangin Ergon, Asli Çeli̇k, Ayşe Gülden Di̇ni̇z Ünlü, Rüya Çolak, Senem Alkan Özdemi̇r, Şebnem Çalkavur, Osman Yilmaz
Evaluation Of Syringin?S Neuroprotective Effect In A Model Of Neonatal Hypoxic-Ischemic Brain Injury, Ezgi̇ Yangin Ergon, Asli Çeli̇k, Ayşe Gülden Di̇ni̇z Ünlü, Rüya Çolak, Senem Alkan Özdemi̇r, Şebnem Çalkavur, Osman Yilmaz
Turkish Journal of Medical Sciences
Background/aim: A significant cause of mortality and morbidity in the neonatal era is hypoxic-ischemic encephalopathy (HIE). This study examined the histopathological analysis and neuroprotective impact of syringin (SYR) in an experimental HIE rat model. Material and methods: On the 7th postnatal day, 24 Wistar albino rats were evaluated in 3 groups using the HIE model under gas anesthesia. In the experiment, Group A received 10 mg/kg SYR plus dimethyl sulfoxide (DMSO), Group B received DMSO only, and Group C served as a sham group. Immunohistochemical techniques were used to assess apoptotic cell measurement and proinflammatory cytokines (TNF-? and IL-1ß primary …
Comparison Of Craniotomy And Limited Membranectomy With Conventional Techniques In The Treatment Of Chronic Subdural Hematoma, Mehmet Emi̇n Akyüz, Mehmet Hakan Şahi̇n, Mehmet Kürşat Karadağ
Comparison Of Craniotomy And Limited Membranectomy With Conventional Techniques In The Treatment Of Chronic Subdural Hematoma, Mehmet Emi̇n Akyüz, Mehmet Hakan Şahi̇n, Mehmet Kürşat Karadağ
Turkish Journal of Medical Sciences
Background/aim: Chronic subdural hematoma is the most frequently operated on intracranial hemorrhage worldwide. Although surgical results are satisfactory, recurrence remains an important problem. In this study, it was aimed to evaluate patients who underwent craniotomy with limited membranectomy (CwLM) in terms of recurrence rate and other complications. Materials and methods: Electronic records of 291 consecutive patients who were operated on at our clinic (Atatürk University Yakutiye Research Hospital) between 2015 and 2020 were retrospectively reviewed. Their radiological images at the time of admission, clinical status, any early postoperative complications, and clinical status at the 6-month follow-up were all evaluated. Results: …
Reporting The Clinical Spectrum Of Children With Igav In A Retrospective 24-Year Cohort: Influences Of Age And Sex On Clinical Presentation, Sema Yildirim, Müferet Ergüven
Reporting The Clinical Spectrum Of Children With Igav In A Retrospective 24-Year Cohort: Influences Of Age And Sex On Clinical Presentation, Sema Yildirim, Müferet Ergüven
Turkish Journal of Medical Sciences
Background/aim: Immunoglobulin A vasculitis (IgAV) is one of the most common types of vasculitis in children. The aims of this study were to investigate the clinical characteristics of the disease, and the effects of age and sex on the clinical course in children with IgAV. Materials and methods: This was a retrospective study including pediatric patients diagnosed with IgAV who attended follow-ups at the pediatric rheumatology department of a tertiary healthcare institution between January 1997 and December 2020. The patients were grouped and compared according to sex and age at diagnosis (<7 years vs. ?7 years). Results: The study included 709 children with IgAV, 392 (55.3%) of whom were male. The mean age at diagnosis was 7.9 ± 3.2 years. The most common disease onset season was autumn (31.2%). Upper respiratory infections (27.8%) were the most common predisposing factors. Gastrointestinal system (GIS), joint, and renal involvement were observed in 52.8%, 47.5%, and 17.5% of patients, respectively. Renal involvement, GIS involvement, and disease relapse were significantly more common among those diagnosed after 7 years of age compared to those diagnosed before the age of 7 (p < 0.001, p = 0.033, and p < 0.001, respectively). Scrotal involvement and subcutaneous edema were more common among those diagnosed at younger than 7 years compared to those aged ?7 years at diagnosis (p < 0.001 and p = 0.016, respectively). GIS involvement was more frequently seen in males compared to females (p = 0.046). Conclusion: It was demonstrated that being ?7 years of age at diagnosis or being a male were associated with higher likelihood of renal and GIS involvement in children with IgAV.
Developmental Characteristics Of Williams-Beuren Syndrome And Evaluation Of Adaptive Behavioral Skills, Şenay Güven Baysal, Feyzullah Necati̇ Arslan, Mehmet Aki̇f Büyükavci, Fatma Hi̇lal Yağin, Cemal Eki̇ci̇, Zeynep Esener, Derya Doğan
Developmental Characteristics Of Williams-Beuren Syndrome And Evaluation Of Adaptive Behavioral Skills, Şenay Güven Baysal, Feyzullah Necati̇ Arslan, Mehmet Aki̇f Büyükavci, Fatma Hi̇lal Yağin, Cemal Eki̇ci̇, Zeynep Esener, Derya Doğan
Turkish Journal of Medical Sciences
Background/aim: Williams-Beuren syndrome (WBS) is a rare genetic disorder with delays in language and cognitive development, but, with increased awareness of clinical features and a reliable diagnostic test, WBS is becoming more widely recognized in childhood. Adaptive behavior skills and/or maladaptive behavior are important for the prognosis of individuals with WBS. The aim of this study was to investigate the clinical and developmental characteristics of patients with WBS and further increase awareness about it by evaluating the adaptive skills and maladaptive behaviors of the patients. Materials and methods: The data of WBS patients followed-up at the Developmental Behavioral Pediatrics Unit …
Comparison Of The Efficiencies Of Intrathecal And Intraganglionic Injections In Mouse Dorsal Root Ganglion, Mehmet Şeri̇f Aydin, Esra Nur Yi̇ği̇t
Comparison Of The Efficiencies Of Intrathecal And Intraganglionic Injections In Mouse Dorsal Root Ganglion, Mehmet Şeri̇f Aydin, Esra Nur Yi̇ği̇t
Turkish Journal of Medical Sciences
Background/aim: Dorsal root ganglia (DRG) are structures containing primary sensory neurons. Intraganglionic (IG) and intrathecal (IT) applications are the most common methods used for viral vector transfer to DRG. We aim to compare the efficiencies and pathological effects of IT and IG viral vector delivery methods to DRG, through in vivo imaging. Materials and methods: Mice were divided into four groups of six each: IT, IG, IT-vehicle, and IG-vehicle. Adeno-associated virus (AAV) injection was performed for EGFP expression in IT/IG groups. DRGs were made visible through vertebral window surgery and visualized with multiphoton microscopy. After imaging, spinal cords and DRGs …
Hsa-Circ-0006091 Modulates The Proliferation Of Hepatocellular Carcinoma Via The Mir-622/Ccnb1 Axis, Xiaofeng Zhao, Ling He
Hsa-Circ-0006091 Modulates The Proliferation Of Hepatocellular Carcinoma Via The Mir-622/Ccnb1 Axis, Xiaofeng Zhao, Ling He
Turkish Journal of Medical Sciences
Background/aim: Hepatocellular carcinoma (HCC) is a common type of cancer. We hypothesize that circular RNA-0006091 (circ0006091) affects the progression of HCC. The study aims to investigate the effect of circ-0006091 in HCC cells. Materials and methods: The levels of circ-0006091, microRNA-622 (miR-622), and cyclin B1 (CCNB1) were assayed using qRT-PCR and western blotting. The metastasis of the HCC cells was measured with wound healing and transwell assays. The protein expression levels of MMP-2 and MMP-9 were assayed with western blotting. Dual-luciferase reporter and RNA-pulldown assays were used to determine the link between miR-622 and circ-0006091 or CCNB1. Mice-based tests were …
Adjustable Bone Plate: From Bench To Operating Room, Gazi̇ Huri̇, Erdi̇ Özdemi̇r, Ömer Sunkar Bi̇çer, Pinar Huri̇, Sai̇t Polat, Tuğçe Sapmaz, Mahmut Nedi̇m Doral
Adjustable Bone Plate: From Bench To Operating Room, Gazi̇ Huri̇, Erdi̇ Özdemi̇r, Ömer Sunkar Bi̇çer, Pinar Huri̇, Sai̇t Polat, Tuğçe Sapmaz, Mahmut Nedi̇m Doral
Turkish Journal of Medical Sciences
Background/aim: We have designed an adjustable bone plate (ABP) which allows bone shortening and lengthening after fixation, which is a property not present in any of the plate systems available today. The aim of the current study was to examine the new ABP?s segmental bone transfer capability for the treatment of a segmental bone defect in an animal model. Materials and methods: Five sheep had ABPs attached to 10 of their tibias and bone defects of 15 mm in size were created. The pinion mechanism was moved with a manual screwdriver at a rate of 1mm/day for 15 days starting …
Recurrent Lower Urinary Tract Infections: More Than An Infection For Older Women, Sencer Gani̇dağli, Ercüment Öztürk, Zeynel Abi̇di̇n Öztürk
Recurrent Lower Urinary Tract Infections: More Than An Infection For Older Women, Sencer Gani̇dağli, Ercüment Öztürk, Zeynel Abi̇di̇n Öztürk
Turkish Journal of Medical Sciences
Background/aim: Older adults tend to have more urinary tract infections (UTIs). The frequency of recurrent lower urinary tract infections (rLUTIs) increases with age. rLUTIs are associated with long-term chronic effects on geriatric syndromes in older adults. We aimed to investigate possible risk factors that influence rLUTIs in older adults based on comprehensive geriatric assessment (CGA). Materials and methods: This cross-sectional study included 235 older adults admitted to Gaziantep University?s Geriatric Outpatient Clinic between June 1 and November 30, 2022. All patients underwent CGA. The Geriatric Depression Scale (GDS), the European Quality of Life-Five Dimension (EQ-5D) questionnaire, the Pittsburgh Sleep Quality …
The Importance Of Length And Area Estimate For Forensic Medicine Without Using A Measurement Tool, Ahmet Turla, Hüseyi̇n Kara, Ni̇lay Cankurt Ayar, Berna Aydin, Fulya Zeynep Levent, Oğuzhan Külbaz
The Importance Of Length And Area Estimate For Forensic Medicine Without Using A Measurement Tool, Ahmet Turla, Hüseyi̇n Kara, Ni̇lay Cankurt Ayar, Berna Aydin, Fulya Zeynep Levent, Oğuzhan Külbaz
Turkish Journal of Medical Sciences
Background/aim: Accurately measuring and recording the length or area of lesions affects the judgement of the forensic report, surgical wound management and, in some countries, the billing of health care services. The aim of this study was to determine whether the length and area of lesions described by physicians by estimation are accurate. Materials and methods: This study was designed as a cross-sectional descriptive study and was conducted with 494 participants consisting of internists and physicians at Ondokuz Mayıs University, Faculty of Medicine. The participants were asked to estimate the lengths or areas of 6 different shapes in the questionnaire …
Mirror Neuron Activity Depending On The Content And Stage Of The Observed Action: A Tms Study, H. Evren Boran, Hasan Kilinç, Bülent Cengi̇z
Mirror Neuron Activity Depending On The Content And Stage Of The Observed Action: A Tms Study, H. Evren Boran, Hasan Kilinç, Bülent Cengi̇z
Turkish Journal of Medical Sciences
Background/aim: The firing rate of the mirror neuron system in monkeys decreases systematically with more repetitions. The aim of this study is to investigate whether the activity of the mirror neuron system varies based on the observed movement and the contents of the action, as well as whether there is inhibition in the mirror neuron system when humans observe repeated actions. If inhibition is present, the second question of the study is whether it is related to the organization of the observed action. Materials and methods: Fourteen healthy volunteers participated in the study. Transcranial magnetic stimulation was applied to the …
The Validity And Reliability Of The Diabetic Foot Scale-Short Form (Dfs-Sf) In The Turkish Population: A Methodological Study, Meryem Kiliç, Ayi̇şe Karadağ, Neşe Koçakgöl
The Validity And Reliability Of The Diabetic Foot Scale-Short Form (Dfs-Sf) In The Turkish Population: A Methodological Study, Meryem Kiliç, Ayi̇şe Karadağ, Neşe Koçakgöl
Turkish Journal of Medical Sciences
Background/aim: Diabetic foot ulcers (DFUs) cause decreased quality of life due to prolonged hospital stay, loss of workforce, disabilities, psychological trauma, and increased healthcare costs. This study aims to assess the validity and reliability of the Diabetic Foot ScaleShort Form (DFS-SF) for Turkish-speaking individuals with DFUs. Materials and methods: This was a methodological study conducted with 174 Turkish patients with DFUs from March 2020 to December 2020. Translation?back translation was performed for language equivalence and expert opinions were obtained for content validity. The scale?s construct validity was tested with confirmatory factor analysis, exploratory factor analysis, and known-group validity. Cronbach?s alpha …
Clinical Parameters Of Laminoplasty And Laminectomy With Fusion In The Treatment Of Cervical Spondylosis And Analysis Of Postoperative Sagittal Balance, Mehmet Yi̇ği̇t Akgün, Özkan Ateş, Mehmet Ali̇ Tepebaşili, Caner Günerbüyük, Ali̇ Fahi̇r Özer
Clinical Parameters Of Laminoplasty And Laminectomy With Fusion In The Treatment Of Cervical Spondylosis And Analysis Of Postoperative Sagittal Balance, Mehmet Yi̇ği̇t Akgün, Özkan Ateş, Mehmet Ali̇ Tepebaşili, Caner Günerbüyük, Ali̇ Fahi̇r Özer
Turkish Journal of Medical Sciences
Background/aim: Cervical spondylosis is a progressive disease that causes degenerative changes affecting the spine, intervertebral discs, facets, and ligaments. With anterior and posterior surgical interventions, effective treatments can be applied in cervical spondylotic myelopathy (CSM). The relationship between regional and global spinal alignment and functional and pain outcomes was examined and it was revealed that these parameters play a significant role in obtaining good results. The aim of this study was to compare the perioperative and follow-up results of patients with CSM who underwent laminoplasty or laminectomy with fusion. Materials and method: CSM patients who were operated on between 2015 …
Correlation Of Metal Ions With Specific Brain Region Volumes In Neurodegenerative Diseases, İsmet Murat Melek, Berna Kuş, Zülal Kaptan, Emi̇ne Petekkaya
Correlation Of Metal Ions With Specific Brain Region Volumes In Neurodegenerative Diseases, İsmet Murat Melek, Berna Kuş, Zülal Kaptan, Emi̇ne Petekkaya
Turkish Journal of Medical Sciences
Background/aim: There are reports stating that deteriorations in metal homeostasis in neurodegenerative diseases promote abnormal protein accumulation. In this study, the serum metal levels in Alzheimer?s disease (AD) and Parkinson?s disease (PD) and its relationship with the cortical regions of the brain were investigated. Materials and methods: The patients were divided into 3 groups consisting of the AD group, PD group, and healthy control group (n = 15 for each). The volumes of specific brain regions were measured over the participants? 3-dimensional magnetic resonance images, and they were compared across the groups. Copper, zinc, iron, and ferritin levels in the …
Evaluation Of Chronic Pruritus And Associated Skin Findings In Patients With Diabetes Mellitus, Fatma Avci Merdi̇n, Ahmet Taha Aydemi̇r, Fatma Nur Korkmaz, Fatma Tuğçe Şah Ünal, Asena Gökçay Canpolat, Ayşe Öktem, Özgür Demi̇r, Mustafa Şahi̇n, Rifat Emral, Murat Fai̇k Erdoğan, Sevi̇m Güllü, Aydin Vedi̇a Gedi̇k, Peli̇n Koçyi̇ği̇t, Demet Çorapçioğlu
Evaluation Of Chronic Pruritus And Associated Skin Findings In Patients With Diabetes Mellitus, Fatma Avci Merdi̇n, Ahmet Taha Aydemi̇r, Fatma Nur Korkmaz, Fatma Tuğçe Şah Ünal, Asena Gökçay Canpolat, Ayşe Öktem, Özgür Demi̇r, Mustafa Şahi̇n, Rifat Emral, Murat Fai̇k Erdoğan, Sevi̇m Güllü, Aydin Vedi̇a Gedi̇k, Peli̇n Koçyi̇ği̇t, Demet Çorapçioğlu
Turkish Journal of Medical Sciences
Background/aim: To explore the dermatological lesions associated with chronic pruritus in patients who were followed up at our clinic for type 1 and type 2 diabetes mellitus (DM). Materials and methods: The study population consisted of 249 patients with DM, who presented to the endocrinology clinic at Ankara University Faculty of Medicine between January 2022, and March 2022, regardless of whether they had reported experiencing pruritus symptoms. The visual analog scale and 5-D itch scale were used to determine the severity of itching in patients. Dermatological examination findings were also evaluated. Results: Of the 249 patients with DM, mean duration …
Thrombotic Risk Assessment In Antiphospholipid Syndrome: Do Noncriteria Antibodies Contribute?, Ömer Uludağ, Suzan Çinar, Thomas Mcdonnell, Erhan Çene, Yasemi̇n Yalçinkaya, Ahmet Gül, Murat İnanç, Bahar Artim Esen
Thrombotic Risk Assessment In Antiphospholipid Syndrome: Do Noncriteria Antibodies Contribute?, Ömer Uludağ, Suzan Çinar, Thomas Mcdonnell, Erhan Çene, Yasemi̇n Yalçinkaya, Ahmet Gül, Murat İnanç, Bahar Artim Esen
Turkish Journal of Medical Sciences
Background/aim: In this cross-sectional study, it was aimed to test the predictive value of noncriteria antiphospholipid antibodies (aPL) in addition to the global antiphospholipid syndrome score (GAPSS) in predicting vascular thrombosis (VT) in a cohort of patients with APS and aPL (+) systemic lupus erythematosus (SLE). Material and methods: This study included 50 patients with primary APS, 68 with SLE/APS, and 52 with aPL (+) SLE who were classified according to VT as VT ± pregnancy morbidity (PM), PM only or aPL (+) SLE. Antiphospholipid serology consisting of lupus anticoagulant (LA), anticardiolipin (aCL) immunoglobulin G (IgG)/IgM/IgA, antibeta2 glycoprotein I (aß2GPI) …
The Diagnostic Profile And Clinical Course Of Patients With Rheumatic Diseases In The Medical Intensive Care Unit, Kani̇ye Aydin, İpek Türk
The Diagnostic Profile And Clinical Course Of Patients With Rheumatic Diseases In The Medical Intensive Care Unit, Kani̇ye Aydin, İpek Türk
Turkish Journal of Medical Sciences
Background/aim: Immunosuppressive and immunomodulatory treatments developed in recent years as a result of a better understanding of the pathophysiology of systemic rheumatic diseases (SRDs) improve the prognosis. Despite medical advances, individuals with SRDs at any stage may require intensive care and have a high mortality rate. The aim of this study was to investigate the demographic and clinical characteristics of patients with rheumatic diseases admitted to the intensive care unit (ICU), and the factors associated with the risk of mortality. Materials and methods: This was a retrospective, cross-sectional study that included patients with rheumatic diseases in the medical ICU. Factors …
Alterations In B And Nk Cells Highly Correlate With Disease Severity In Children With Covid-19, Ezgi̇ Topyildiz, Nesli̇han Karaca, Razi̇ye Burcu Taşkin, Ayşe Aygün, Zümrüt Şahbudak Bal, Eylem Ulaş Saz, Nuri̇ Zafer Kurugöl, Neci̇l Kütükçüler, Güzi̇de Aksu
Alterations In B And Nk Cells Highly Correlate With Disease Severity In Children With Covid-19, Ezgi̇ Topyildiz, Nesli̇han Karaca, Razi̇ye Burcu Taşkin, Ayşe Aygün, Zümrüt Şahbudak Bal, Eylem Ulaş Saz, Nuri̇ Zafer Kurugöl, Neci̇l Kütükçüler, Güzi̇de Aksu
Turkish Journal of Medical Sciences
Background/aim: Children with coronavirus disease 2019 (COVID-19) present milder symptoms than adults and are at lower risk of hospitalization and life-threatening complications. However, the kinetics of lymphocyte subsets and serum immunoglobulins in the peripheral blood during COVID-19 infection remains unclear. In this study, it was aimed to determine the changes in hematological and immunological parameters, especially in the lymphocyte subsets, in the peripheral blood of children with different COVID-19 disease severity. Materials and methods: The study was planned as a prospective cohort and included 68 children aged 0?18 years who were admitted to Ege University Faculty of Medicine Department of …
Effect Of Thoracic Mobilization Exercises On Hamstring Flexibility: A Randomized Controlled Trial, Aybüke Ersi̇n, Meltem Kaya
Effect Of Thoracic Mobilization Exercises On Hamstring Flexibility: A Randomized Controlled Trial, Aybüke Ersi̇n, Meltem Kaya
Turkish Journal of Medical Sciences
Background and aim: The aim was to investigate the effect of thoracic mobilization exercises on hamstring flexibility. Materials and methods: One hundred twenty individuals with hamstring tightness were included in the study. The participants were randomized into two groups: the experimental group (EG) (n = 60) or the control group (CG) (n = 60). The EG performed a homebased thoracic mobilization exercise program comprising 2 sets with 10 repetitions, once a day, 3 days a week, for 4 weeks. The CG performed active-assisted stretching of the hamstring comprising 3 sets with 10 repetitions for 15 seconds. The active knee extension …
Body Mass Index Does Not Affect Response Of Rituximab In Patients With Rheumatoid Arthritis: Results From The Turkbi̇o Registry, Ahmet Karataş, Rabi̇a Pi̇şki̇n Sağir, Süleyman Serdar Koca, Hüseyi̇n Edi̇z Dalkiliç, Gerçek Can, Yavuz Pehli̇van, Ayten Yazici, Güzi̇de Nevsun İnanç, Ayşe Çefle, Zeynep Ertürk, Servet Akar, Soner Şenel, Ahmet Meri̇h Bi̇rli̇k, Nurullah Akkoç, Fatoş Önen
Body Mass Index Does Not Affect Response Of Rituximab In Patients With Rheumatoid Arthritis: Results From The Turkbi̇o Registry, Ahmet Karataş, Rabi̇a Pi̇şki̇n Sağir, Süleyman Serdar Koca, Hüseyi̇n Edi̇z Dalkiliç, Gerçek Can, Yavuz Pehli̇van, Ayten Yazici, Güzi̇de Nevsun İnanç, Ayşe Çefle, Zeynep Ertürk, Servet Akar, Soner Şenel, Ahmet Meri̇h Bi̇rli̇k, Nurullah Akkoç, Fatoş Önen
Turkish Journal of Medical Sciences
Background/aim: Adipose tissue produces several inflammatory mediators. Thus, obesity affects the disease course and the responses to the antirheumatic agents in inflammatory diseases. The aim of the study was to determine whether the body mass index (BMI) is involved in the response to rituximab in rheumatoid arthritis (RA). Materials and methods: This multicenter retrospective study included 206 RA patients who received rituximab from the Turkish Biologic (TURKBIO) registry between 2011 and the end of May 2017. Demographic and clinical data including age, sex, disease type, disease duration, and previous or current treatment with disease-modifying antirheumatic drugs (DMARDs) and biological drug …
Comparison Of The Effect Of Postweaning Social Isolation, Enriched Environment, And Exercise Training On Learning And Memory Functions In Rats, Hati̇ce Eki̇nalan Kayhan, Ni̇lsel Okudan, Muaz Belvi̇ranli
Comparison Of The Effect Of Postweaning Social Isolation, Enriched Environment, And Exercise Training On Learning And Memory Functions In Rats, Hati̇ce Eki̇nalan Kayhan, Ni̇lsel Okudan, Muaz Belvi̇ranli
Turkish Journal of Medical Sciences
Background/aim: To assess the effects of postweaning social isolation, an enriched environment, and exercise training on learning and memory functions in rats, as well as their relation with the brain-derived neurotrophic factor (BDNF) and nerve growth factor (NGF) concentrations in the hippocampus. Materials and methods: Randomly assigned into 4 groups were 35 female postweaning rats (25 day old), as the control (C), social isolation (SI), enriched environment (EE), and exercise training (E) groups. The SI and the EE groups were housed under their specific conditions and the E and the C groups were housed under standard conditions for 6 weeks. …
Current Developments In Surface Electromyography, Veysel Alcan, Murat Zi̇nnuroğlu
Current Developments In Surface Electromyography, Veysel Alcan, Murat Zi̇nnuroğlu
Turkish Journal of Medical Sciences
Background/aim: Surface electromyography (surface EMG) is a primary technique to detect the electrical activities of muscles through surface electrodes. In recent years, surface EMG applications have grown from conventional fields into new fields. However, there is a gap between the progress in the research of surface EMG and its clinical acceptance, characterized by the translational knowledge and skills in the widespread use of surface EMG among the clinician community. To reduce this gap, it is necessary to translate the updated surface EMG applications and technological advances into clinical research. Therefore, we aimed to present a perspective on recent developments in …
Levetiracetam Ameliorates Epileptogenesis By Modulating The Adenosinergic Pathway In A Kindling Model Of Epilepsy In Mice, Muhammad Jamal, Muhammad Azam, Salman Ali Khan, Zaheer Ul-Haq, Shabana Usman Simjee
Levetiracetam Ameliorates Epileptogenesis By Modulating The Adenosinergic Pathway In A Kindling Model Of Epilepsy In Mice, Muhammad Jamal, Muhammad Azam, Salman Ali Khan, Zaheer Ul-Haq, Shabana Usman Simjee
Turkish Journal of Medical Sciences
Background: Levetiracetam (LEV) has been found to have an antihyperalgesic effect via acting on the adenosine system. However, the effects of LEV on the modulation of the adenosine system in the brain have not been elucidated in the prevention of seizures and epilepsy. The present study aimed to explore the possible LEV mechanisms of action in the adenosine signaling systems in an animal model of epilepsy. Methodology: A docking study was initially performed to determine the possible interaction of LEV with adenosine A1 receptors (A1Rs) and equilibrative nucleoside transporters-1 (ENT1). The experimental study was divided into an acute seizure test …